FRANCE Last Updated: 2007-05-22

Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration

Goitre Urinary iodine (µg/L) Notes prevalence (%) Distribution (%) Prevalence (%) Age Sample Grade Grade TGP <20 20-49 50-99100-299 >300 <100 Median Mean SD Reference General Line Level Date Region and sample descriptor Sex (years) size 1 2 S 2000 North department: Infants/Pre-SAC: Total B 0.00 - 6.99 160 2.0 5.0 17.0 24.0 195.5 4755 * 1 Infants B 0.00 - 0.49 54 2.0 2.0 13.0 17.0 183.0 Infants/Pre-SAC B 0.50 - 1.99 58 3.0 7.0 21.0 31.0 160.0 Pre-SAC B 2.00 - 6.99 48 2.0 6.0 15.0 23.0 261.0

N 1996 SU.VI.MAX Cohort: Women: Total F 35.00 - 60.99 7154 82.0 1269 * SU.VI.MAX Cohort: Men: Total M 45.00 - 60.99 4860 85.0 Women by region: Bourgogne F 35.00 - 60.99 NS 78.0 Women by region: Bretagne F 35.00 - 60.99 NS 84.0 Women by region: Ile de France F 35.00 - 60.99 NS 84.0 Women by region: Rhone-Alpes F 35.00 - 60.99 NS 71.0 Women by regions: Alsace/Lorraine/Frache-Comt F 35.00 - 60.99 NS 75.0 Women by regions: Auvergne/Limousin F 35.00 - 60.99 NS 67.0 Women by regions: Haute/Basse Normadie F 35.00 - 60.99 NS 85.0 Women by regions: Nord-Pas-de-Calais/Picardie F 35.00 - 60.99 NS 86.0 Women by regions: PACA/Languedoc-Roussillon F 35.00 - 60.99 NS 69.0 2 Women by regions: Poitou-Charentes/Aquitaine/M F 35.00 - 60.99 NS 83.0 Men by region: Bourgogne M 45.00 - 60.99 NS 85.0 Men by region: Bretagne M 45.00 - 60.99 NS 96.0 Men by region: Ile de France M 45.00 - 60.99 NS 88.0 Men by region: Rhone-Alpes M 45.00 - 60.99 NS 74.0 Men by regions: Alsace/Lorraine/Frache-Comté/C M 45.00 - 60.99 NS 75.0 Men by regions: Auvergne/Limousin M 45.00 - 60.99 NS 76.0 Men by regions: Haute/Basse Normadie M 45.00 - 60.99 NS 88.0 Men by regions: Nord-Pas-de-Calais/Picardie M 45.00 - 60.99 NS 96.0 Men by regions: PACA/Languedoc-Roussillon M 45.00 - 60.99 NS 77.0 3 Men by regions: Poitou-Charentes/Aquitaine/Midi- M 45.00 - 60.99 NS 89.0 SU.VI. MAX Cohort: Women F 35.00 - 60.99 7154 13.9 * SU.VI. MAX Cohort: Men M 45.00 - 60.99 4860 11.3

R 1994 ThyroMobil study 4 regions: SAC: Total B 6.00 - 14.99 1458 120.0 130 74.0 1329 * 4 SAC by region: Languedoc-Roussillon B 6.00 - 14.99 418 138 75.0 SAC by region: Lorraine B 6.00 - 14.99 338 127 74.0 SAC by region: Midi-Pyrénées B 6.00 - 14.99 409 126 76.0 SAC by region: Rhone-Alpes B 6.00 - 14.99 293 128 67.0 SAC by city: Albi B 6.00 - 14.99 119 121 65.0 5 SAC by city: Artemare B 6.00 - 14.99 55 105 59.0 6 SAC by city: Bagnols/ceze B 6.00 - 14.99 72 130 64.0 7

© WHO Global Database on Iodine Deficiency Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration

FRANCE Last Updated: 2007-05-22

Goitre Urinary iodine (µg/L) Notes prevalence (%) Distribution (%) Prevalence (%) Age Sample Grade Grade TGP <20 20-49 50-99100-299 >300 <100 Median Mean SD Reference General Line Level Date Region and sample descriptor Sex (years) size 1 2 R 1994 SAC by city: Epinal B 6.00 - 14.99 47 94 70.0 1329 8 SAC by city: Foix B 6.00 - 14.99 98 129 86.0 9 SAC by city: Gignac B 6.00 - 14.99 121 145 91.0 10 SAC by city: Ligny en Barrois B 6.00 - 14.99 112 129 75.0 11 SAC by city: Lyon B 6.00 - 14.99 168 134 67.0 12 SAC by city: Mende B 6.00 - 14.99 105 142 68.0 13 SAC by city: Meyzieu B 6.00 - 14.99 69 131 73.0 14 SAC by city: Nancy B 6.00 - 14.99 85 135 78.0 15 SAC by city: Port Vendres B 6.00 - 14.99 120 133 67.0 16 SAC by city: Rodez B 6.00 - 14.99 116 126 69.0 17 SAC by city: Toulouse B 6.00 - 14.99 76 131 86.0 18 SAC by city: Uckange B 6.00 - 14.99 94 134 68.0 19

L 1994P Paris: Infants B 0.83 - 0.91 456 17.3 18.0 181.0 5140 * Paris: Pre-SAC by age B 2.00 - 2.99 368 28.8 32.3 134.0 Paris: Pre-SAC by age B 4.00 - 4.99 398 35.2 37.2 116.0

L 1993 -1994 Southwest France: PW F 18.00 - 42.99 306 50 69 4 3851 * 20 Southwest France: PW F 18.00 - 42.99 224 54 86 6 21

L 1986 -1989 Commune d'Arsac-en-Velay: Adults B NS 25 1330a * 22 Canton de Bess-en-Chandesse: Adults B NS 38 23 Canton de Bess-en-Chandesse: Adults: Total B NS 169 8.9 * Commune d'Arsac-en-Velay: Adults: Total B NS 56 16.1 Women by canton: Bess-en-Chandesse F NS 103 12.6 Women by commune: Arsac-en-Velay F NS 35 20.0 Men by canton: Bess-en-Chandesse M NS 66 3.0 Men by commune: Arsac-en-Velay M NS 21 9.5

R 1984 -1986 Auvergne Region: SAC: Total B 10.00 - 16.99 87 1330b * 24 SAC by department: Allier B 10.00 - 16.99 22 25 SAC by department: Cantal B 10.00 - 16.99 11 26 SAC by department: Haute-Loire B 10.00 - 16.99 17 27 SAC by department: Puy-de-Dôme B 10.00 - 16.99 37 28 Auvergne region: SAC: Total B 10.00 - 16.99 4919 12.5 * SAC by department: Allier B 10.00 - 16.99 1056 7.2 SAC by department: Cantal B 10.00 - 16.99 972 11.9 SAC by department: Haute-Loire B 10.00 - 16.99 912 10.6

FRANCE Last Updated: 2007-05-22

FRANCE

Reference no 4755 General Notes: Facility based study (primary health care centres); sample selected from 5 health care centres in the Notrth department. Line note 1 Mean age: 17.7 months.

Reference no 1269 General Notes: Cross-sectional survey of a sample of the SU.VI.MAX Cohort, reference No. 1270 reports UI and thyroid volume (ultrasonography) in a subsample. Line note 2 PACA = Provence-Alpes-Cote-d'Azur

Line note 3 PACA = Provence-Alpes-Cote-d'Azur

Reference no 1329 General Notes: Sample comprised SAC from 4 regions (Rhone-Alpes, Lorraine, Midi-Pyrénées and Languedoc-Roussillon); data extracted from reference No. 1329, 1319 and 3384. Line note 4 UI median range: 85.0-131.0 µg/L

Line note 5 Midi-Pyrénées region. Line note 6 Rhone-Alpes region. Line note 7 Languedoc-Roussillon region. Line note 8 Lorraine region. Line note 9 Midi-Pyrénées region. Line note 10 Languedoc-Roussillon region. Line note 11 Lorraine region. Line note 12 Rhone-Alpes region. Line note 13 Languedoc-Roussillon region. Line note 14 Rhone-Alpes region. Line note 15 Lorraine region. Line note 16 Languedoc-Roussillon region. Line note 17 Midi-Pyrénées region. Line note 18 Midi-Pyrénées region. Line note 19 Lorraine region. Reference no 5140 General Notes: Facility based study (children's health examination centre); subjects randomly selected among children undergoing free medical check-up in the Paris area; same survey reported in reference No. 2142.

Reference no 3851 General Notes: Facility-based cohort study with a total of 347 consecutive pregnant women, enrolled between July 1993 and April 1994; subjects were seen in at the out patients department of hospitals or private clinics located in nine cities (Albi, Cahors, Castres, Foix, Lavaur, Motauban, Rodez, Saint Gaudens and Toulouse). Line note 20 PW during the first trimester. Line note 21 PW at ninth month of pregnancy.

© WHO Global Database on Iodine Deficiency Reference no 1330a General Notes: Sample comprised subjects from the commune d'Arsac-en-Velay, Haute-Loire department and canton de Bess-en-Chandesse, Puy-de-Dome department, Auvergne region.

Line note 22 UI mean (SD): 59.78 (41.77) µg/g Cr Line note 23 UI mean (SD): 43.45 (33.48) µg/g Cr Reference no 1330b General Notes: Sample comprised SAC from the region of Auvergne (study related to the National French School Children Study); UI expressed in µg/g creatinine, values reported in the respective line notes.

Line note 24 UI mean (SD): 62.9 (34.3) µg/g Cr Line note 25 UI mean (SD): 64 (44.3) µg/g Cr Line note 26 UI mean (SD): 73.3 (38.3) µg/g Cr Line note 27 UI mean (SD): 51.3 (15.5) µg/g Cr Line note 28 UI mean (SD): 64.4 (32.3) µg/g Cr

Reference 1269 Valeix P, Zarebska M, Preziosi P, Galán P, Pelletier B, Hercberg S. Iodine deficiency in France. Lancet, 1999, 353 :1766-1767.

Reference 1329 Caron P, Jaffiol C, Leclere J, Orgiazzi J, Delange F. Apport iodé en France: résultats nationaux du projet thyromobile dans un population d'enfants scolarisés de 6 à 14 ans [Iodine consumption in France: national results of the Thyromobile project in a population of schoolchildren aged 6-14 years]. Annales d'Endocrinologie, 1996, 57 :228-233.

Reference 1330 Thieblot P, Samrani J, Tauveron I. Epidémiologie du goitre en Auvergne [Epidemiology of goiter in Auvergne]. Annales d'Endocrinologie, 1992, 53 :107-111.

Reference 3851 Caron P, Hoff M, Bazzi S, Dufor A, Faure G, Ghandour I, Lauzu P, Lucas Y, Maraval D, Mignot F, Ressigeac P, Vertongen F, Grange V. Urinary iodine excretion during normal pregnancy in healthy women living in the southwest of France: correlation with maternal thyroid parameters. Thyroid, 1997, 7 :749-754.

Reference 4755 Pouessel G, Bouarfa K, Soudan B, Sauvage J, Gottrand F, Turck D. Statut en iode et facteurs de risque e déficit en iode chez des enfants vus en consultation de protection maternelle et infantile dans le départment du Nord [Iodine nutritional status and risk factors for iodine deficiency in infants and children of the french North department]. Archives de Pédiatrie, 2003, 10 :96-101.

Reference 5140 Valeix P, Preziosi P, Rossignol C, Farnier MA, Hercberg S. Relationship between urinary iodine concentration and hearing capacity in children. European Journal of Clinical Nutrition, 1994, 48 :54-59.

Reference 228 Mornex R, Boucherat M, Lamand M, Tressol JC, Jaffiol C. Goitre prevalence and salt iodization in France. In: Delange F et al., eds. Iodine deficiency in Europe. A continuing concern. New York, Plenum Press, 1993 :363-366.

Reference 536 Mornex R. Enquête sur la prévalence du goitre en France [Survey of goiter prevalence in France]. Bulletin de l'Académie Nationale de Médecine, 1987, 171 :301-306.

Reference 545 Blum CJ, Lafont C, Ducasse M, Hoff M, Labarre I, Bayard F, Albarede JL. Thyroid function tests in ageing and their relation to associated nonthyroidal disease. Journal of Endocrinological Investigation, 1989, 12 :307-312.

Reference 1270 Barrère X, Valeix P, Preziosi P, Bensimon M, Pelletier B, Galán P, Hercberg S. Determinants of thyroid volume in healthy French adults participating in the SU.VI.MAX cohort. Clinical Endocrinology, 2000, 52 :273-278.

Reference 1271 Jaffiol C, Gobert M, Cailhol A, Baylet R, Baldet L, Lachiver F, Chapate M, Mirouze J. Étude approfondie complémentaire d'une enquête épidémiologique réalisée en milieu scolaire sur la fréquence du goitre et la carence iodée en Languedoc-Roussillon [Supplemental in-depth study of an epidemiological survey performed in a school environment on the occurrence of goiter and iodine deficiency in Languedoc-Roussillon]. Bulletin de l'Académie Nationale de Médecine, 1987, 171 :1095-1101.

Reference 2142 Valeix P, Preziosi P, Rossignol C, Farnier MA, Hercberg S. Iodine intakes assessed by urinary iodine concentrations in healthy children aged ten months, two years, and four years. Biological Trace Element Research, 1992, 32 :259-266.

Reference 5141 Agence Française de Securite Sanitaire des Aliments. Évaluation de l'mpact nutritionnel de l'introduction de composés iodés dans les produits agroalimemtaires. France, Agence Française de Securite Sanitaire des Aliments., 2005.