Clemson University TigerPrints All Dissertations Dissertations 5-2020 X-Panding Halogen Bonding Interactions: Hybrid Cocrystals Composed of Ionic Halides, Iodine and Organoiodines Khadijatul Kobra Clemson University Follow this and additional works at: https://tigerprints.clemson.edu/all_dissertations Part of the Chemistry Commons Recommended Citation Kobra, Khadijatul, "X-Panding Halogen Bonding Interactions: Hybrid Cocrystals Composed of Ionic Halides, Iodine and Organoiodines" (2020). All Dissertations. 2572. https://tigerprints.clemson.edu/all_dissertations/2572 This Dissertation is brought to you for free and open access by the Dissertations at TigerPrints. It has been accepted for inclusion in All Dissertations by an authorized administrator of TigerPrints. For more information, please contact
[email protected]. X-PANDING HALOGEN BONDING INTERACTIONS: HYBRID COCRYSTALS COMPOSED OF IONIC HALIDES, IODINE AND ORGANOIODINES A Dissertation Presented to the Graduate School of Clemson University In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Chemistry by Khadijatul Kobra May 2020 Accepted by: William T. Pennington, Committee Chair Colin D. McMillen, Committee Co-chair Joseph S. Thrasher Stephen E. Creager Rakesh Sachdeva i ABSTRACT Halogen bonding referred to as an attractive, noncovalent interaction between an electrophilic region of a halogen atom X (acts as Lewis acid) and a nucleophilic region of a molecule Y (acts as Lewis base). Such interactions and the resulting polymeric networks play an important role in many fields related to crystal engineering, including for example, the fabrication of liquid crystals and novel drug design. The application of halogen bonding has particular promise in biological systems by increasing the lipophilicity of drugs to improve penetration through lipid membranes and tissues, enabling better intracellular delivery.