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A Prophylactic Α-Gal-Based Glycovaccine Effectively Protects Against Murine Acute Chagas Disease
www.nature.com/npjvaccines ARTICLE OPEN A prophylactic α-Gal-based glycovaccine effectively protects against murine acute Chagas disease Susana Portillo1, Brenda G. Zepeda1, Eva Iniguez1, Janet J. Olivas1, Nasim H. Karimi1, Otacilio C. Moreira2, Alexandre F. Marques1,3, Katja Michael4, Rosa A. Maldonado1 and Igor C. Almeida 1 Chagas disease (ChD), caused by the hemoflagellate parasite Trypanosoma cruzi, affects six to seven million people in Latin America. Lately, it has become an emerging public health concern in nonendemic regions such as North America and Europe. There is no prophylactic or therapeutic vaccine as yet, and current chemotherapy is rather toxic and has limited efficacy in the chronic phase of the disease. The parasite surface is heavily coated by glycoproteins such as glycosylphosphatidylinositol (GPI)-anchored mucins (tGPI-mucins), which display highly immunogenic terminal nonreducing α-galactopyranosyl (α-Gal)-containing glycotopes that are entirely absent in humans. The immunodominant tGPI-mucin α-Gal glycotope, the trisaccharide Galα1,3Galβ1,4GlcNAc (Galα3LN), elicits high levels of protective T. cruzi-specific anti-α-Gal antibodies in ChD patients in both the acute and chronic phases. Although glycoconjugates are the major parasite glycocalyx antigens, they remain completely unexplored as potential ChD vaccine candidates. Here we investigate the efficacy of the T. cruzi immunodominant glycotope Galα3LN, covalently linked to a carrier protein (human serum albumin (HSA)), as a prophylactic vaccine candidate in the acute model of ChD, using the α1,3- galactosyltransferase-knockout (α1,3GalT-KO) mouse, which mimics the human immunoresponse to α-Gal glycotopes. Animals vaccinated with Galα3LN-HSA were fully protected against lethal T. -
MCA-700 Midline/Reissue Series
MCA 700 Discography by David Edwards, Mike Callahan & Patrice Eyries © 2018 by Mike Callahan MCA-700 Midline/Reissue Series: By the time the reissue series reached MCA-700, most of the ABC reissues had been accomplished in the MCA 500-600s. MCA decided that when full price albums were converted to midline prices, the albums needed a new number altogether rather than just making the administrative change. In this series, we get reissues of many MCA albums that were only one to three years old, as well as a lot of Decca reissues. Rather than pay the price for new covers and labels, most of these were just stamped with the new numbers in gold ink on the front covers, with the same jackets and labels with the old catalog numbers. MCA 700 - We All Have a Star - Wilton Felder [1981] Reissue of ABC AA 1009. We All Have A Star/I Know Who I Am/Why Believe/The Cycles Of Time//Let's Dance Together/My Name Is Love/You And Me And Ecstasy/Ride On MCA 701 - Original Voice Tracks from His Greatest Movies - W.C. Fields [1981] Reissue of MCA 2073. The Philosophy Of W.C. Fields/The "Sound" Of W.C. Fields/The Rascality Of W.C. Fields/The Chicanery Of W.C. Fields//W.C. Fields - The Braggart And Teller Of Tall Tales/The Spirit Of W.C. Fields/W.C. Fields - A Man Against Children, Motherhood, Fatherhood And Brotherhood/W.C. Fields - Creator Of Weird Names MCA 702 - Conway - Conway Twitty [1981] Reissue of MCA 3063. -
4 Steps to a More Relaxed Pregnancy: Antenatal Coping and Relaxation
4 STEPS TO A MORE RELAXED PREGNANCY: ANTENATAL COPING AND RELAXATION INTERVENTION MANUAL Authors: Heather O’Mahen, Dorothy King, Esther Wilkinson, Pasco Fearon, Sarah Halligan, Leonie Lee- Carbon, Jeannette Milgrom, Jennifer Ericksen, Jacqueline Dunkley-Bent, Anna Birbrajer, Paul Ramchandani Group set-up • Arrive in plenty of time to set up and prepare • Therapists should plan out the session together in advance – bear your particular group in mind • Arrange chairs in a circle (and remove any tables) • Have the flipchart ready where everyone can see it • Have refreshments available in a corner of the room • Have pens and paper available • Have tissues available • Have name badges ready to hand out when people arrive • Have session handouts ready • Therapists ready to welcome people Things for therapists to bear in mind • Be mindful of timings – try to stick roughly to the given timings, but be a bit flexible in order meet to the needs of your particular group • Try to ensure a balance in group discussion, paying equal attention to individuals • Aim to draw quiet members in by asking them directly for contributions (gently) • If one or two members of the group are dominating the discussion, try to balance things out – thank them for their contribution and direct questions to the rest of the group • It’s ok to go into detail on individual examples as long as they are relevant to the group discussion. Try to draw on a variety of examples from different members of the group. • If asked medical/midwifery questions, it’s ok to answer them if you can do so briefly (and if they aren’t very specific to that individual). -
Discography of the Turbo Label
The Labels of Joe and Sylvia Robinson The All-Platinum Label was formed by Joe and Sylvia Robinson, husband and wife in New Jersey in 1969. Sylvia Robinson was one-half of the duo Mickey and Sylvia of “Love is Strange” fame. George Kerr and the Robinson’s were responsible for A&R. Joe Robinson had parlayed a music publishing company that he established years before in New York into the All-Platinum, Stang, and Turbo record labels. Artists included his wife Sylvia, The Moments, Brother to Brother, Shirley and Company, Linda Jones, Jack McDuff and Chuck Jackson The labels were All-Platinum, Stang, Turbo and Vibration. All-Platinum distributed Charisma (US) which released Malcolm X recordings, More which released Eldridge Cleaver recordings and Maple which released R&B and Psychedelic. In the late 70’s All-Platinum went bankrupt. The Robinson’s then formed Sugar Hill Records in 1979 with Milton Malden and financial funding of Morris Levy, the owner of Roulette Records and pioneered Rap Music The Sugar Hill label's first record was "Rapper's Delight" (1979) by The Sugarhill Gang, which was also the first Top 40 hip hop single. Afterwards Grandmaster Flash, The Sequence, Funky Four Plus One, Crash Crew, Kool Moe Dee, The West Street Mob, and Melle Mel joined the label. Sugar Hill's in-house producer and arranger was Clifton "Jiggs" Chase. The in-house recording engineer was Steve Jerome. Al Goodman, leader of The Moments, ran the show and George Kerr was a major producer. Joe and Sylvia's sons Joey and Leland were also active in the business. -
Escape from Wonderland - a Novel Crystal Denise Pennymon University of Texas at El Paso, [email protected]
University of Texas at El Paso DigitalCommons@UTEP Open Access Theses & Dissertations 2018-01-01 Escape From Wonderland - A Novel Crystal Denise Pennymon University of Texas at El Paso, [email protected] Follow this and additional works at: https://digitalcommons.utep.edu/open_etd Part of the Creative Writing Commons, and the Fine Arts Commons Recommended Citation Pennymon, Crystal Denise, "Escape From Wonderland - A Novel" (2018). Open Access Theses & Dissertations. 1511. https://digitalcommons.utep.edu/open_etd/1511 This is brought to you for free and open access by DigitalCommons@UTEP. It has been accepted for inclusion in Open Access Theses & Dissertations by an authorized administrator of DigitalCommons@UTEP. For more information, please contact [email protected]. ESCAPE FROM WONDERLAND - A NOVEL - CRYSTAL DENISE PENNYMON Master’s Program in Creative Writing APPROVED: Tim Hernandez, M.F.A., Chair Elizabeth Sheid, M.F.A. Jose De Pierola, Ph.D. Charles Ambler, Ph.D. Dean of the Graduate School Dedication To my grandmother, Annie Lois Price Pennymon June 3, 1927 – October 29, 2015 To my aunt, Janice Maria Pennymon Morgan March 17, 1958 – September 3, 2016 To my baby brother, Jonathan Dennard Pennymon May 9, 1985 – July 13, 2017 ESCAPE FROM WONDERLAND -A NOVEL- by CRYSTAL DENISE PENNYMON, B.S. THESIS Presented to the Faculty of the Graduate School of Liberal Arts The University of Texas at El Paso in Partial Fulfillment of the Requirements for the Degree of MASTER OF FINE ARTS Department of Creative Writing THE UNIVERSITY OF TEXAS AT EL PASO May 2018 Acknowledgements In remembrance of my grandmother, Annie Lois Pennymon (1927-2015), who said that I told little lies all the way from Georgia to Kentucky while sitting on the arm rest of her Oldsmobile Toronado at 3-years-old. -
General Vertical Files Anderson Reading Room Center for Southwest Research Zimmerman Library
“A” – biographical Abiquiu, NM GUIDE TO THE GENERAL VERTICAL FILES ANDERSON READING ROOM CENTER FOR SOUTHWEST RESEARCH ZIMMERMAN LIBRARY (See UNM Archives Vertical Files http://rmoa.unm.edu/docviewer.php?docId=nmuunmverticalfiles.xml) FOLDER HEADINGS “A” – biographical Alpha folders contain clippings about various misc. individuals, artists, writers, etc, whose names begin with “A.” Alpha folders exist for most letters of the alphabet. Abbey, Edward – author Abeita, Jim – artist – Navajo Abell, Bertha M. – first Anglo born near Albuquerque Abeyta / Abeita – biographical information of people with this surname Abeyta, Tony – painter - Navajo Abiquiu, NM – General – Catholic – Christ in the Desert Monastery – Dam and Reservoir Abo Pass - history. See also Salinas National Monument Abousleman – biographical information of people with this surname Afghanistan War – NM – See also Iraq War Abousleman – biographical information of people with this surname Abrams, Jonathan – art collector Abreu, Margaret Silva – author: Hispanic, folklore, foods Abruzzo, Ben – balloonist. See also Ballooning, Albuquerque Balloon Fiesta Acequias – ditches (canoas, ground wáter, surface wáter, puming, water rights (See also Land Grants; Rio Grande Valley; Water; and Santa Fe - Acequia Madre) Acequias – Albuquerque, map 2005-2006 – ditch system in city Acequias – Colorado (San Luis) Ackerman, Mae N. – Masonic leader Acoma Pueblo - Sky City. See also Indian gaming. See also Pueblos – General; and Onate, Juan de Acuff, Mark – newspaper editor – NM Independent and -
Bulletin of the Center for Children's Books
I LL I NOI S UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN PRODUCTION NOTE University of Illinois at Urbana-Champaign Library Large-scale Digitization Project, 2007. Graduate School of Library and Information Science University of Illinois Press at ;i .I~i ;;-i·i· , 01-' -y n a r,i "A handsome puzzle book that also enhances appreciation for our quirky mother tongue."* JUD ITH VIORST The Alphabet from Z to A (With Much Confusion on the Way) Illustrated in full color by Richard Hull * "Refreshingly, Viorst offers anything but a basic introduc- tion to phonetics....Rather, her verse is a pleasing blend of play- fulness and sophistication.... [Hull's] detailed, often fantastical pictures cleverly incorporate the items mentioned in Viorst's rhymes - as well as a devilish number of other objects that begin with the spotlighted letter. It all makes for good (and vocabulary- building) phun." -Starred, Publishers Weekly "Intriguing." -School Library Journal 'qThe well-known humorist uses a reverse alphabet to explore, and rail about, the idiosyncra- ces of English ('Y' is for YEW and for YOUJ But it isn't for USING), touching on the vagaries of homonyms and spelling, slip- ping in rhymes...and engaging in other wordplay." -*Kirkus Reviews "Kids will be charmed to see someone acknowledge the appar- ent idiocy of the language they're grappling with." -Booklist $14.95 SBE/0-689-31768-9 Ages 7-10 SBE indicates a reinforced hardcover edition. Atheneum An imprint of the Simon & Schuster Children's Publishing Division A Paramount Communications Company -- THE BUvL LE T IN OF THE CENTER FOR CHILDREN'S BOOKS June 1994 Vol. -
Old Time Banjo
|--Compilations | |--Banjer Days | | |--01 Rippling Waters | | |--02 Johnny Don't Get Drunk | | |--03 Hand Me down My Old Suitcase | | |--04 Moonshiner | | |--05 Pass Around the Bottle | | |--06 Florida Blues | | |--07 Cuckoo | | |--08 Dixie Darling | | |--09 I Need a Prayer of Those I Love | | |--10 Waiting for the Robert E Lee | | |--11 Dead March | | |--12 Shady Grove | | |--13 Stay Out of Town | | |--14 I've Been Here a Long Long Time | | |--15 Rolling in My Sweet Baby's Arms | | |--16 Walking in the Parlour | | |--17 Rye Whiskey | | |--18 Little Stream of Whiskey (the dying Hobo) | | |--19 Old Joe Clark | | |--20 Sourwood Mountain | | |--21 Bonnie Blue Eyes | | |--22 Bonnie Prince Charlie | | |--23 Snake Chapman's Tune | | |--24 Rock Andy | | |--25 I'll go Home to My Honey | | `--banjer days | |--Banjo Babes | | |--Banjo Babes 1 | | | |--01 Little Orchid | | | |--02 When I Go To West Virginia | | | |--03 Precious Days | | | |--04 Georgia Buck | | | |--05 Boatman | | | |--06 Rappin Shady Grove | | | |--07 See That My Grave Is Kept Clean | | | |--08 Willie Moore | | | |--09 Greasy Coat | | | |--10 I Love My Honey | | | |--11 High On A Mountain | | | |--12 Maggie May | | | `--13 Banjo Jokes Over Pickin Chicken | | |--Banjo Babes 2 | | | |--01 Hammer Down Girlfriend | | | |--02 Goin' 'Round This World | | | |--03 Down to the Door:Lost Girl | | | |--04 Time to Swim | | | |--05 Chilly Winds | | | |--06 My Drug | | | |--07 Ill Get It Myself | | | |--08 Birdie on the Wire | | | |--09 Trouble on My Mind | | | |--10 Memories of Rain | | | |--12 -
100M Dash (5A Girls) All Times Are FAT, Except
100m Dash (5A Girls) All times are FAT, except 2 0 2 1 R A N K I N G S A L L - T I M E T O P - 1 0 P E R F O R M A N C E S 1 12 Nerissa Thompson 12.35 North Salem 1 Margaret Johnson-Bailes 11.30a Churchill 1968 2 12 Emily Stefan 12.37 West Albany 2 Kellie Schueler 11.74a Summit 2009 3 9 Kensey Gault 12.45 Ridgeview 3 Jestena Mattson 11.86a Hood River Valley 2015 4 12 Cyan Kelso-Reynolds 12.45 Springfield 4 LeReina Woods 11.90a Corvallis 1989 5 10 Madelynn Fuentes 12.78 Crook County 5 Nyema Sims 11.95a Jefferson 2006 6 10 Jordan Koskondy 12.82 North Salem 6 Freda Walker 12.04c Jefferson 1978 7 11 Sydney Soskis 12.85 Corvallis 7 Maya Hopwood 12.05a Bend 2018 8 12 Savannah Moore 12.89 St Helens 8 Lanette Byrd 12.14c Jefferson 1984 9 11 Makenna Maldonado 13.03 Eagle Point Julie Hardin 12.14c Churchill 1983 10 10 Breanna Raven 13.04 Thurston Denise Carter 12.14c Corvallis 1979 11 9 Alice Davidson 13.05 Scappoose Nancy Sim 12.14c Corvallis 1979 12 12 Jada Foster 13.05 Crescent Valley Lorin Barnes 12.14c Marshall 1978 13 11 Tori Houg 13.06 Willamette Wind-Aided 14 9 Jasmine McIntosh 13.08 La Salle Prep Kellie Schueler 11.68aw Summit 2009 15 12 Emily Adams 13.09 The Dalles Maya Hopwood 12.03aw Bend 2016 16 9 Alyse Fountain 13.12 Lebanon 17 11 Monica Kloess 13.14 West Albany C L A S S R E C O R D S 18 12 Molly Jenne 13.14 La Salle Prep 9th Kellie Schueler 12.12a Summit 2007 19 9 Ava Marshall 13.16 South Albany 10th Kellie Schueler 12.01a Summit 2008 20 11 Mariana Lomonaco 13.19 Crescent Valley 11th Margaret Johnson-Bailes 11.30a Churchill 1968 -
Bossypants? One, Because the Name Two and a Half Men Was Already Taken
Acknowledgments I would like to gratefully thank: Kay Cannon, Richard Dean, Eric Gurian, John Riggi, and Tracy Wigfield for their eyes and ears. Dave Miner for making me do this. Reagan Arthur for teaching me how to do this. Katie Miervaldis for her dedicated service and Latvian demeanor. Tom Ceraulo for his mad computer skills. Michael Donaghy for two years of Sundays. Jeff and Alice Richmond for their constant loving encouragement and their constant loving interruption, respectively. Thank you to Lorne Michaels, Marc Graboff, and NBC for allowing us to reprint material. Contents Front Cover Image Welcome Dedication Introduction Origin Story Growing Up and Liking It All Girls Must Be Everything Delaware County Summer Showtime! That’s Don Fey Climbing Old Rag Mountain Young Men’s Christian Association The Windy City, Full of Meat My Honeymoon, or A Supposedly Fun Thing I’ll Never Do Again Either The Secrets of Mommy’s Beauty Remembrances of Being Very Very Skinny Remembrances of Being a Little Bit Fat A Childhood Dream, Realized Peeing in Jars with Boys I Don’t Care If You Like It Amazing, Gorgeous, Not Like That Dear Internet 30 Rock: An Experiment to Confuse Your Grandparents Sarah, Oprah, and Captain Hook, or How to Succeed by Sort of Looking Like Someone There’s a Drunk Midget in My House A Celebrity’s Guide to Celebrating the Birth of Jesus Juggle This The Mother’s Prayer for Its Daughter What Turning Forty Means to Me What Should I Do with My Last Five Minutes? Acknowledgments Copyright * Or it would be the biggest understatement since Warren Buffett said, “I can pay for dinner tonight.” Or it would be the biggest understatement since Charlie Sheen said, “I’m gonna have fun this weekend.” So, you have options. -
Download the Supplementary Information (PDF)
An arsenic-driven pump for invisible gold in hydrothermal systems G.S. Pokrovski, C. Escoda, M. Blanchard, D. Testemale, J.-L. Hazemann, S. Gouy, M.A. Kokh, M.-C. Boiron, F. de Parseval, T. Aigouy, L. Menjot, P. de Parseval, O. Proux, M. Rovezzi, D. Béziat, S. Salvi, K. Kouzmanov, T. Bartsch, R. Pöttgen, T. Doert Supplementary Information The Supplementary Information includes: 1. Materials: Description of Experimental and Natural Sulfarsenide Samples 2. Methods: Analytical, Spectroscopic and Theoretical Methods 3. Supplementary Text: Additional Notes on Thermodynamic Approaches Tables S-1 to S-11 Figures S-1 to S-12 Supplementary Information References Geochem. Persp. Let. (2021) 17, 39-44 | doi: 10.7185/geochemlet.2112 SI-1 1. Materials: Description of Experimental and Natural Sulfarsenide Samples 1.1. Experimental samples Three types of experiments at controlled laboratory conditions have been performed to produce synthetic Au-bearing sulfarsenide minerals (Tables S-1, S-2). Two hydrothermal types (MA, CE and LO series, Table S-1) in the presence of aqueous solution were conducted at temperature (T) of 450 °C and pressures (P) of 700–750 bar. The choice of these T-P parameters for hydrothermal MA, CE et LO series is dictated by the following reasons: i) they the pertinent to T-P conditions of hydrothermal ore deposits hosting sulfarsenide minerals in the Earth’s crust (~150–600 °C and <5 kbar) being roughly in the middle of the typical T-P window for magmatic porphyry Cu-Mo-Au and metamorphic Au ore deposits (e.g., Goldfarb et al., -
Leech-Wilkinson, Compositions, Scores, Performances, Meanings
Volume 18, Number 1, April 2012 Copyright © 2012 Society for Music Theory Compositions, Scores, Performances, Meanings Daniel Leech-Wilkinson NOTE: The examples for the (text-only) PDF version of this item are available online at: http://www.mtosmt.org/issues/mto.12.18.1/mto.12.18.1.leech-wilkinson.php KEYWORDS: Performance, Performance Style, Theory, Analysis, Ontology ABSTRACT: The standard model of musical transmission, in which composers embody their intentions in works which they encode in scores which performers (and scholars in their imagination) decode as accurately as possible for audiences, is unpicked in the light of the evidence of recorded performance. It is replaced with a model that recognizes the large extent to which performances trigger the generation of musical meaning in the minds of listeners, and the extent to which changes in performance style cause those meanings to change. Some implications for thought about music are considered. Received January 2012 I [1.1] It is still generally assumed that musical meaning is encoded in works by composers. I say “still” because there has been a lot of research, and a fair number of publications over the past two decades, that raise doubts about that easy assumption, yet none of it seems to have made much difference to the way scores are taught, analyzed, or discussed. Studies of specific instances of musical affect frequently treat the composer as if s/he were the principal agent of meaning. “Schubert lingers affectively on this glimpse of bucolic happiness, though without slackening the pace of the song” (Kramer 1998, 129). “Beethoven hurls forth the P 0 module, Allegro vivace, in a set of three impetuous, downward-cast precipitations, measures 1–8” (Hepokoski 2010, 11).