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The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and
Function
Xi Chen1, Ayala Iriscilla1, Chris Shannon1, Marcel Fourcaudot1, Nikhil K Acharya2, Christopher P
Jenkinson3, Sami Heikkinen4 and Luke Norton1*
Affiliations: 1Diabetes Division, University of Texas Health Science Center, San Antonio, TX; 2Diabetes
and Obesity Center of Excellence, University of Washington, Seattle, WA; 3South Texas Diabetes and
Obesity Institute, University of Texas Rio Grande Valley, Harlingen, TX; 4Institute of Biomedicine,
University of Eastern Finland, Kuopio, Finland
Key words: Type 2 diabetes, TCF7L2, adipose tissue, adipogenesis, Wnt signaling
Running title: Role of TCF7L2 in adipose tissue
Word Count (main): 4,793
Word Count (abstract): 195
Figures and Tables: 7 main figures, 9 supplementary figures, 1 supplementary table, 1 supplementary data
*Address all correspondence to:
Luke Norton, PhD
Email: [email protected]
1
Diabetes Publish Ahead of Print, published online January 9, 2018 Diabetes Page 2 of 79
Abstract
The gene encoding for transcription factor 7 like 2 (TCF7L2) is the strongest type 2 diabetes
(T2DM) candidate gene discovered to date. The TCF7L2 protein is a key transcriptional effector of the
Wnt/β catenin signaling pathway, which is an important developmental pathway that negatively regulates adipogenesis. However, the precise role that TCF7L2 plays in the development and function of adipocytes remains largely unknown. Using a combination of in vitro approaches, we first show that TCF7L2 protein is increased during adipogenesis in 3T3 L1 cells and primary adipocyte stem cells (ASC), and that
TCF7L2 expression is required for the regulation of Wnt signaling during adipogenesis. Inactivating
TCF7L2 protein by removing the HMG box DNA binding domain in mature adipocytes in vivo leads to whole body glucose intolerance and hepatic insulin resistance. This phenotype is associated with increased subcutaneous adipose tissue mass, adipocyte hypertrophy and inflammation. Finally, in humans with impaired glucose tolerance (IGT) and adipocyte insulin resistance we demonstrate that TCF7L2 mRNA expression is downregulated, highlighting the translational potential of these findings. In summary our data indicate that TCF7L2 has key roles in adipose tissue development and function that may reveal, at least in part, how TCF7L2 contributes to the pathophysiology of T2DM.
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Introduction
The human TCF7L2 gene is the strongest candidate gene for type 2 diabetes (T2DM) [1]. Intronic
single nucleotide polymorphisms (SNPs) within TCF7L2 consistently have been linked to an array of
phenotypes related to T2DM [2; 3]. However, what impact TCF7L2 has on the development and function
of adipose tissue remains to be fully elucidated.
In a landmark study by the MacDougald lab, expression of the Wnt pathway activator, Wnt1, in
preadipocyte cell lines potently blocked adipogenesis [4]. Follow up experiments demonstrated that
pharmacological activation of Wnt signaling stabilized β catenin and blocked preadipocyte differentiation
[4; 5]. Conversely, inhibition of Wnt signaling stimulates adipogenesis through a β catenin dependent
pathway [6; 7], and crosstalk between β catenin and key transcriptional regulators of adipogenesis has
been demonstrated [7; 8]. Moreover, in multipotent precursors of the mesenchymal lineage, activation of
Wnt/β catenin stimulates osteoblastogenesis and inhibits adipogenesis [9]. The consensus from these
studies is that Wnt signaling inhibits adipogenesis and that β catenin is a critical mediator of this effect.
Consistent with an inhibitory effect of Wnt activation on adipogenesis, over expression of
TCF7L2 lacking its β catenin binding domain promotes adipogenesis in pre adipocytes and in L6
myotubes [4; 10]. In humans, obesity interacts with the TCF7L2 risk allele to enhance T2DM prevalence
in non obese subjects [11; 12], and the TCF7L2 gene is differentially methylated in adipose tissue of
T2DM patients [13]. Moreover, weight loss following gastric bypass surgery led to differential expression
of TCF7L2 mRNA isoforms in subcutaneous fat biopsies. The expression of short TCF7L2 isoforms was
also more prevalent in T2DM patients, suggesting an important role for TCF7L2 alternative splicing in
adipose tissue [14].
Despite these findings, key questions regarding the molecular and physiological role of TCF7L2
in adipose tissue remain. For example, it is not known if TCF7L2 expression is regulated during
adipogenesis, whether TCF7L2 protein levels are important to adipocyte development, or how TCF7L2
interacts with Wnt signaling in developing adipocytes. The physiological impact of TCF7L2 loss of
function in adipocytes also remains to be elucidated and, at the genomic level, it is not known which
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genes TCF7L2 regulates in adipocytes. These are important studies that may reveal novel functions of
TCF7L2 that may help us understand the association between TCF7L2 SNPs and T2DM risk.
In preliminary studies we observed that TCF7L2 protein levels increased during adipogenesis in
3T3 L1 cells. Because this appeared inconsistent with the paradigm of TCF7L2 mediated inhibition of adipogenesis, we further explored the role of TCF7L2 in adipose tissue in vitro and in vivo. The data described in the present study suggest that TCF7L2 may, in fact, be required for adipogenesis, and that its expression is important for the regulation of Wnt/β catenin signaling during adipocyte development. Post
development, blocking the transcriptional activity of TCF7L2 in rodent adipose tissue leads to
subcutaneous adipocyte hypertrophy, whole body glucose intolerance and hepatic insulin resistance.
Finally, in humans we demonstrate that adipose tissue expression of TCF7L2 is lower in subjects with
impaired glucose tolerance (IGT) and adipocyte insulin resistance. These findings highlight new and
complex roles for TCF7L2 in adipose tissue development and function, and further uncover novel
mechanisms by which this important transcription factor may contribute to obesity and T2DM.
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Materials and Methods
Cell culture: Early passage 3T3 L1 cells were differentiated using standard procedures in the
absence of thiazolidinediones [15]. Primary ASC were isolated from inguinal fat pads of 4 – 6 week old
mice and differentiated into adipocytes, as described previously [16]. Triglyceride accumulation was
quantitated using a commercial assay (Abcam, Cambridge, UK). For Wnt/β catenin pathway inhibition
experiments, IWR 1 endo was purchased from Selleckchem (Texas, USA) and used at a final
concentration of 10 µM. Protein content was determined using the BCA assay, and cell number was
analyzed using the TC10 automated cell counter (Biorad, USA).
TCF7L2 Lentiviral shRNA: Stable silencing of Tcf7l2 mRNA was performed in low passage
3T3 L1 fibroblasts (passage 2) using SMARTvector (Dharmacon, USA) lentiviral shRNAs. Puromycin
selection was used to isolate a heterogeneous cell population post infection. Additional stable clones were
generated using alternate plasmids and shRNA sequences that targeted different regions of the Tcf7l2
gene. All shRNA sequences used in this study are provided in Supplementary Fig 1.
Insulin Stimulated Glucose Uptake: Glucose uptake in differentiated (day 8) adipocytes was
quantitated using a 3H 2 deoxyglucose during a 30 minute insulin incubation (200 nM) [17]. Data were
corrected for negative control wells treated without insulin and/or cytochalasin B.
Western blot analysis: Western blotting was carried out as described [18]. Membranes were
probed with the following antibodies, all supplied by Cell Signaling Technology (Danvers, MA, USA):
TCF7L2 (number 2569), β catenin (number 8480), non phospho Ser33/37/Thr41 (active) β catenin
(number 8814), total AKT (number 4691), phospho Ser473 AKT (pAKT) (number 4060), C/EBPβ
(number 3087), C/EBPδ (number 2318), C/EBPα (number 2295), PPAR γ (number 2435), FABP4
(number 2120). The β tubulin antibody (ab6046) was from Abcam (Cambridge, MA, USA).
RNA sequencing and pathway enrichment analysis: RNA Seq was performed on shSCR and
shTCF7L2 3T3 L1 cells at multiple time points during adipogenesis, and analyzed as described [18].
Differentially expressed genes (DEG) were required to have an FDR q value < 0.05 when comparing the
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shTCF7L2 against shSCR cells. Pathway enrichment analysis was performed using Gene Set Enrichment
Analysis (GSEA). Raw sequencing data is available online (GEO accession number: GSE95029).
Animals: Mice with LoxP sites flanking exon 11 of the mouse Tcf7L2 gene have been described elsewhere [19]. Adiponectin Cre (Adipoq Cre) mice were obtained from Jackson Lab (stock # 010803).
LoxP/LoxP littermate controls were used in all experiments. Mice were fed either a standard chow or, starting at 8 weeks of age, 60% high fat diet (HFD; Research Diets, D12492).
Mouse Physiological studies: Glucose tolerance tests (IPGTT) and insulin tolerance tests (ITT) were carried out essentially as described [20]. For IPGTTs, mice were fasted for 10 h and 2g/kg (3 month old mice) or 50 mg (HFD mice) was given intraperitoneally (IP). For ITT, mice were fasted for 5 h and a dose of 0.8 U/kg was given IP. Low dose (1.5 mU m 2 min 1) hyperinsulinemic euglycemic clamps were used to assess hepatic insulin sensitivity in 3 month old control and TCF7L2 mutant mice ( E11
TCF7L2). Clamp data were normalized to total body weight. Indirect calorimetry was carried out using
Promethion (Sable Systems, NV, USA; 3 month old mice) or TSE Labmaster (TSE Systems, MO, USA;
6 month old mice) metabolic cages. Differences in energy expenditure (EE) were assessed using the
NIDDK Mouse Metabolic Phenotyping Centers ANCOVA method [21]. Body composition was assessed
using a Minispec Nuclear Magnetic Resonance (NMR) analyzer (Bruker, MA, USA). Adipocyte size
determination was performed on formalin fixed adipose tissue using Adiposoft software [22].
Human Studies: Fasting abdominal subcutaneous adipose tissue biopsies were obtained from subjects with and without adipose tissue insulin resistance (Adipo IR), as previously described [23]. All subjects underwent a standard 2 h oral glucose tolerance tests (OGTT) to confirm normal glucose tolerance (NGT) or impaired glucose tolerance (IGT). Fasting Adipo IR was calculated from free fatty acid (FFA) and insulin data [24]. Adipose tissue RNA was extracted using standard protocols and qRT
PCR carried out for TCF7L2 as previously described [18].
Statistical tests: Data are presented as univariate scatter plots or line graphs, with corresponding mean ± SD. GraphPad Prism v7.03 was used for all statistical analyses. Data normality was assessed for in vivo experiments using the Shapiro Wilk test, and non parametric Mann Whitney tests were used when
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deviations from normality were detected. Student’s two tailed T tests were used for analysis between two
groups of equal variances, and Welch’s T tests were employed when the F test of equal variance failed.
Data containing three or more groups was analyzed using one or two way anova (adjusted for repeat
measures where appropriate) with Holm Sidak post hoc testing accounting for multiple comparisons,
where appropriate.
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Results
TCF7L2 expression during adipogenesis: We first quantitated protein levels of TCF7L2 during adipogenesis in 3T3 L1 cells. The TCF7L2 antibody recognizes an epitope around Leu331 (exon 9) of human TCF7L2, and thus detects all protein isoforms of TCF7L2, although only 78 and 58 kDa proteins were detected. Although both protein isoforms increased significantly during adipogenesis, and there was a strong correlation between them (r = 0.95, P < 0.001), the expression of the 58 kDa protein was significantly higher in fully differentiated adipocytes (Fig 1A – C). We measured mouse Tcf7l2 mRNA
using a Taqman probe that spans exon 5 and 6 of full length Tcf7l2, and detects all mRNA variants (assay
ID: Mm00501505_m1). While there was a significant effect of adipogenesis on total Tcf7l2 mRNA
overall (Fig 1D), it remained relatively stable during adipogenesis and was not correlated with the 58 or
78 kDa proteins (P = 0.19 and 0.27, respectively). Consistent with our 3T3 L1 data, TCF7L2 protein
levels increased during differentiation of murine ASCs ex vivo, but there were no differences in the
expression of the 58 or 78 kDa proteins in these cells (Fig 1E).
TCF7L2 expression is required for adipogenesis: We generated stable 3T3 L1 pre adipocytes
with reduced TCF7L2 protein using lentivirus shRNA, and examined the adipogenesis capacity of these
cells. Silencing TCF7L2 protein led to an almost complete block of adipogenesis (Fig 1F). Additional
stable clones generated using different viral backbones and shRNA sequences that targeted alternate
regions of Tcf7l2 mRNA confirmed these findings (Supplementary Fig 1). We did not observe effects of
TCF7L2 silencing on cell proliferation, as determined by protein content and cell number on the day of
adipogenesis induction (Supplementary Fig 1). Consistent with impaired adipogenesis in shTCF7L2
cells, mRNA and protein induction of several adipogenic transcription factors (i.e. PPARγ and C/EBPα)
were reduced in TCF7L2 silenced cells (Supplementary Fig 2). Insulin stimulated glucose uptake also
was reduced in the shTCF7L2 adipocytes, and was associated with intact insulin signaling at the level of pAKT473, but reduced Glut4 (Slc2a4) mRNA expression (Supplementary Fig 3).
TCF7L2 transcriptome in adipocytes: We performed RNA Seq analysis on stable shTCF7L2
3T3 L1 cells (clone shTCF7L2_A) at multiple time points during adipogenesis. In shTCF7L2 pre
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adipocytes we observed an up regulation of multiple inflammatory pathways that persisted for the
duration of the adipogenesis time course (Fig 2). These pathways were related to type I (IFN α) and type
II (IFN γ) interferon responses, and complement pathway activity (Fig 2 and Supplementary Data).
Inflammatory gene up regulation was not related to specific shRNA or plasmid sequences as a selection
of DEG were confirmed using qRT PCR in independent shTCF7L2 clones using alternate shRNA
sequences and plasmids (Supplementary Fig 4). In contrast, the expression of genes involved in
important metabolic processes, including fatty acid, bile acid and cholesterol metabolism, were reduced.
In pre adipocytes pathways involved in epithelial to mesenchymal transition (EMT) and angiogenesis
were downregulated, consistent with important developmental roles for Wnt signaling in these pathways
(Fig 2 and Supplementary Data).
Wnt signaling during adipogenesis: GSEA analysis indicated that the Wnt/β catenin signaling
pathway was not significantly altered in shTCF7L2 3T3L1 cells. However, a number of Wnt genes and
targets were differentially expressed in our RNA Seq dataset (Supplementary Data), and highly related
GSEA pathways were altered in shTCF7L2 cells, including Myc target, Notch and Hedgehog pathways
(Fig 2). Thus, to characterize Wnt signaling in more detail we examined the mRNA expression of a
number of key Wnt genes. The expression of Axin2, a transcriptional marker of Wnt pathway activation
[25; 26], was relatively low in control cells, fluctuated moderately during adipogenesis, but was increased
approximately 7 fold in shTCF7L2 cells (Fig 3A). Interestingly, the expression of lymphoid enhancer
binding factor 1 (Lef1), a key member of the HMG box family of Wnt transcription factors, increased
sharply during adipogenesis in control cells, which was attenuated by TCF7L2 silencing (Fig 3A). The
levels of Myc peaked early on Day 2, where it was increased approximately 10 fold compared to pre
adipocytes. Consistent with the GSEA data, the induction of Myc expression during adipogenesis was
significantly blunted (Fig 3A). The mRNA levels of WNT1 inducible signaling pathway protein 2
(Wisp2), a novel secreted adipokine and Wnt pathway activator [27], were elevated during adipogenesis
in shTCF7L2 cells (Fig 3A). Consistent with previous reports [28], transducin like enhancer of split 3
(Tle3) mRNA increased during adipogenesis in control cells, but its expression was significantly
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attenuated in shTCF7L2 cells (Fig 3A). The mRNA levels of β catenin (Ctnnb1) were moderately affected by adipogenesis, but were not significantly different in shTCF7L2 cells (Fig 3A). In contrast to these mRNA data, total and active β catenin protein were highly expressed in pre adipocytes, and declined during adipogenesis (Fig 3B). Total β catenin protein levels were lower in shTCF7L2 cells, but active β catenin levels were unchanged, resulting in an increase in the active to total β catenin ratio in shTCF7L2 cells (Fig 3B).
To explore the role of β catenin in the inhibition of adipogenesis in shTCF7L2 cells, we treated cells with IWR 1, a small molecule endogenous Wnt signaling antagonist that stabilizes the β catenin destruction complex [29]. In high passage (passage 8) pre adipocyte 3T3 L1 cells with submaximal adipogenesis, IWR 1 treatment led to β catenin degradation, increased Pparg mRNA, and a 2 fold increase in adipogenesis (Fig 3C). This was associated with elevated Lef1 expression, consistent with our data showing increased Lef1 mRNA during adipogenesis. However, in shTCF7L2 cells IWR 1 was unable to restore adipogenesis despite similarly robust β catenin degradation (Fig 3C). Moreover, the effect of IWR 1 on Lef1 and Pparg expression was blocked, and the marked increase in Axin2 mRNA persisted in shTCF7L2 cells (Fig 3C). Taken together these data suggest that the regulation of Wnt signaling during adipogenesis is disturbed in the absence of TCF7L2 expression, and indicate that
TCF7L2 expression is required for adipogenesis.
Generation of Adipocyte Specific E11 TCF7L2 mice: We next investigated the role of
TCF7L2 in mature adipocytes in vivo. Adipoq Cre mediated excision of exon 11 of Tcf7l2, which is common to all Tcf7l2 mRNA variants and encodes the DNA binding domain of TCF7L2, led to the expression of Tcf7l2 mRNA lacking exon 11 only (Fig 4A and B). This functionally inactivates TCF7L2
and blocks TCF7L2 mediated Wnt signaling, and whole body E11 TCF7L2 mice display an identical phenotype to the classic Tcf7l2 knockout mice [19; 30]. Three month old male and female E11 TCF7L2
mice were not significantly heavier than control littermates, and there was no difference in total or lean fat
mass, as assessed in females (Supplementary Fig 5). However, female mice had increased food intake
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and lower fasting leptin. The increased food intake in female mice was offset by an increase in activity as
net energy balance was not significantly increased in these mice (Supplementary Fig 5).
Glucose homeostasis in E11 TCF7L2 mice: At 3 months of age, male (Fig 4D – E) and female
(Supplementary Fig 6) chow fed E11 TCF7L2 mice were glucose intolerant compared to age matched
LoxP/LoxP control mice. The E11 TCF7L2 mice displayed early hyperinsulinemia during the IPGTT
(Fig 4F), and were insulin resistant, as determined by ITTs (Supplementary Fig 6). No difference was
observed in glucose tolerance between LoxP/LoxP control mice and Adipoq Cre mice (data not shown),
consistent with previously published findings [31]. Because male and female mice displayed similar
glucose tolerance phenotypes, further studies were performed in males.
We used low dose hyperinsulinemic euglycemic clamps with [3 3H] glucose infusion to
accurately quantitate basal and insulin stimulated glucose appearance (Ra) and disappearance (Rd).
Consistent with our IPGTT data, the glucose infusion rate (GIR) was reduced during the clamp in E11
TCF7L2 mice (Fig 4G). Basal Ra and Rd were not different in E11 TCF7L2 mice (Fig 4H), but we did
observe increased insulin stimulated Ra (Fig 4I), confirming hepatic insulin resistance in 3 month old
TCF7L2 mutant mice. This phenotype was not associated with hepatic steatosis in the chow fed male
mice, but was associated with increased expression of fasting hepatic stearoyl CoA desaturase 1 (Scd1)
and elevated mRNA levels of several gluconeogenic genes (G6pc, Pck1 and Pcx) at the end of the insulin
clamp (Supplementary Fig 5 and 7).
To examine the mechanisms underlying hepatic insulin resistance in E11 TCF7L2 mice, we fed
mice a 60% HFD for 12 weeks. Cumulative weight gain during the HFD in E11 TCF7L2 was not
significantly different (Fig 5A), but E11 TCF7L2 mice were significantly heavier in absolute body
weight at the end of the diet, despite similar cumulative food intake (Fig 5B - D). Glucose intolerance in
E11 TCF7L2 mice progressed after the HFD to include fasting and 2 h hyperglycemia (Fig 5E - F).
High fat fed E11 TCF7L2 mice also displayed hepatomegaly (not shown), increased lipid deposition on
H&E sections, and increased hepatic triglycerides (Fig 5G – H). These data demonstrate that TCF7L2
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inactivation in mature adipocytes promotes hepatic insulin resistance in chow and HFD mice. In HFD fed
animals, this may at least partially be explained by an increase in lipid deposition in liver.
Adipose tissue morphology in E11 TCF7L2 mice: At 3 months of age there was a small
increase in inguinal (iWAT) adipose tissue mass in male E11 TCF7L2 mice, but this was not
statistically significant (Fig 6A). By 6 months of age, iWAT weight was 2.5 fold larger in E11 TCF7L2
mice, which was maintained after the HFD (Fig 6A). In the younger mice, a significant shift towards
larger adipocytes was already detectable. There was a reduction in smaller adipocytes (500 to 1000 µm2) and a significant increase in the proportion of larger adipocytes over 4000 µm2 (Fig 6B and D). This was exacerbated in older mice where, on average, adipocytes were approximately 2 fold larger compared to controls (Fig 6C and E). In these mice adipocyte area was highly correlated with iWAT weight (Fig 6G),
and we counted fewer adipocytes in the same total histological area in the older E11 TCF7L2 mice (Fig
6F). Although 6 month old mice were heavier and had increased whole body fat mass, they had lower food intake, activity levels and net energy expenditure (Supplementary Fig 8). Thus, net energy balance was not significantly different in these mice. Interestingly, we also did not detect changes in the weight of the perigonadal visceral depot (pgWAT), examined following HFD (Fig 6A).
Adipocyte gene expression in E11 TCF7L2 mice: Consistent with our in vitro data, Axin2, complement factor H (Cfh) and monocyte chemoattractant protein 1 (Ccl2) mRNA were increased in isolated adipocytes from HFD mice, indicating adipocyte hypertrophy is associated with adipose tissue inflammation in E11 TCF7L2 mice (Supplementary Fig 9). Although Pparg mRNA was unchanged, we noted a marked increase in the expression of Dgat2 mRNA, suggesting increased triglyceride synthesis/storage capacity in the hypertrophic adipocytes of E11 TCF7L2 mice (Supplementary Fig 9).
TCF7L2 expression in human adipose tissue: Finally, to examine the clinical significance of these findings we quantitated TCF7L2 mRNA expression in adipose tissue biopsies from patients with
NGT and IGT. The IGT subjects were matched for BMI but had significantly increased Adipo IR (Fig
7D). Total TCF7L2 mRNA, detected using a Taqman probe designed around exons 10 and 11 (assay ID:
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Hs01009038_m1), was significantly decreased in IGT subjects (Fig 7E), as was the expression of a “full
adipose tissue variant” [14] of TCF7L2 that incorporates exons 12 and 13 (Fig 7F).
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Discussion
In this study we demonstrate that the diabetes candidate gene and key Wnt pathway effector
Tcf7l2 has important developmental and metabolic roles in adipose tissue. Previous studies have
demonstrated that over expression of TCF7L2 lacking its β catenin binding domain promotes
spontaneous adipogenesis in pre adipocyte 3T3 L1 cells and skeletal muscle pre cursor cells [4; 5]. These
findings led to the conclusion that TCF7L2 impairs adipogenesis. However, we suspected this was a
simplistic model of TCF7L2 and Wnt signaling activity during adipogenesis. First, several Wnt
components, including TCF7L2 and multiple Wnt ligands and receptors, are expressed in mature, fully
differentiated adipocytes [32; 33]. Second, the transcriptional activity of TCF7L2 is flexible based on its
interaction with β catenin and other transcriptional partners. In the absence of β catenin binding, TCFs largely repress Wnt target genes via the recruitment of nuclear co factors [34]. Third, several secreted
Wnt ligands, including Wnt4, Wnt5a and Wnt5b can stimulate adipogenesis [35; 36]. Lastly, our own preliminary data highlighted that TCF7L2 protein increased during adipogenesis in 3T3 L1 and primary
ASCs.
In our cellular studies stable silencing of TCF7L2 impaired adipogenesis. This was associated with disruption of Wnt signaling, as indicated by a significant upregulation of Axin2 mRNA, and changes in the expression of multiple Wnt genes, including Lef1, Myc and Wisp2. However, the effects of
TCF7L2 silencing on β catenin levels were relatively modest in comparison. Although we did observe a significant increase in the ratio of active:total β catenin, the levels of both proteins fell significantly during adipogenesis in control and shTCF7L2 cells. Furthermore, in rescue experiments employing the
Wnt inhibitor IWR 1, Wnt pathway inhibition through β catenin degradation enhanced adipogenesis in control cells, but this effect was blocked in shTCF7L2 cells. These data, and the persistent alterations in
the expression of Axin2 and Lef1 in IWR 1 treated shTCF7L2 cells, raise the interesting possibility that
TCF7L2 may have β catenin dependent and independent roles in adipocytes, which may vary temporally
during adipogenesis. For example, in developing and mature adipocytes, where β catenin levels are
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relatively low, increasing TCF7L2 expression may suppress Wnt pathway activation and promote
adipogenesis. In contrast, in pre adipocytes, low TCF7L2 levels and high β catenin may permit Wnt
activation and inhibit adipocyte development. This bidirectional feature of TCFs has been demonstrated
in classic Wnt signaling studies performed in Drosophila, Xenopus, and Caenorhabditis elegans [34]. In
support of this putative temporal relationship between β catenin and TCF7L2 during adipogenesis, a
previous study demonstrated that co occupancy of TCF7L2 and β catenin decreases at the Fabp4
promotor as adipogenesis progresses [28]. Furthermore, Tle3 suppresses Wnt signaling, displaces β
catenin bound to TCF7L2 and promotes adipogenesis [28]. Our data demonstrate that Tle3 mRNA levels
are significantly reduced in shTCF7L2 cells, which further suggests an important interaction between
these two proteins to facilitate adipogenesis.
Taken together these findings may be difficult to reconcile with those from studies
overexpressing dominant negative TCF7L2 in pre adipocytes, where increased adipogenesis was
observed [4]. A potential explanation for this discrepancy is that over expression of TCF7L2 that lacks β
catenin binding functionality does not block all transcriptional activity of TCF7L2. On the contrary, high
levels of β catenin binding mutants of TCF7L2 are still able to bind gene promotors and, as discussed
above, can interact with alternate transcriptional partners to promote the expression of pro adipogenic
genes. Thus, our data do not dispute the well established finding that Wnt signaling per se impairs
adipogenesis, but instead highlight a far more complex regulatory role for TCF7L2 during adipogenesis
that may depend on the balance between TCF7L2 and β catenin levels, the timing of their interaction, and
the interaction between TCF7L2 and other co factors at specific gene promoters. Further highlighting this
complexity, in 3T3 L1 cells the shorter TCF7L2 protein was dominant in developing and mature
adipocytes, consistent with a recent report [10]. This isoform differs only in its C terminus and retains all
functional domains of full length TCF7L2 [37]. Clearly, the regulation of adipose tissue development by
TCF7L2, and the role that β catenin and Wnt signaling play in this process, requires further study.
Despite clear differences in the expression of select Wnt genes, GSEA analysis of RNA Seq data
did not identify the Wnt pathway as differentially regulated in shTCF7L2 cells. There are several
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explanations for this. First, significant overlap exists between the Wnt pathway gene set and related pathways that were altered in shTCF7L2 cells and that contain a number of Wnt genes. This was most
apparent for Myc target (which includes Myc), Notch (which includes Tcf7l2, Fzd1, Fzd5, Wnt2 and
Wnt5a) and Hedgehog (which includes Tle3) GSEA pathways. Second, many Wnt genes and targets,
including Tcf7l2 and Ctnnb1, are regulated post translationally during adipogenesis. Third, the GSEA pathway gene set for Wnt signaling does not include a number of key Wnt related genes that were altered
during adipogenesis in shTCF7L2 cells, including Tcf7l2, Wisp1, Wisp2 and Tle3.
Interestingly, however, GSEA analysis did identify increased expression of inflammatory genes
in shTCF7L2 pre adipocytes. This may be an additional mechanism by which TCF7L2 impaired
adipogenesis, as interferon signaling is a negative regulator of adipogenesis [38]. We also noted increased
expression of complement factor H in shTCF7L2 pre adipocytes, which also has been shown to inhibit
adipogenesis [39]. The non canonical branch of the Wnt signaling pathway has documented inflammatory
roles in adipose tissue. In obese mice, Wnt5a ablation reduced adipose tissue inflammation and improved
insulin resistance, while overexpression of Wnt5a in myeloid cells increased inflammation and impaired
glucose tolerance [40]. Consistent with these findings, secreted frizzled related protein 5 (SFRP5), a
Wnt5a antagonist, has been identified as an anti inflammatory adipokine whose secretion is disrupted in
obesity and T2DM [41]. Despite replicating the effects of TCF7L2 silencing on inflammation using
alternative plasmid and shRNA sequences, the possibility that these observations reflect off target effects
unrelated to TCF7L2 silencing cannot be dismissed completely in the present study.
Our in vivo data demonstrate that inactivation of TCF7L2 through deletion of its DNA binding
domain in adipocytes specifically promotes whole body glucose intolerance and hepatic insulin
resistance. Under chow fed conditions, the hepatic insulin resistance was not associated with overt
hepatic lipotoxicity, but was associated with increased expression of gluconeogenic genes following the
insulin clamp, and increased fasting Scd1 levels. The increase in hepatic Scd1 is noteworthy because it
has important roles in the early onset of lipid induced hepatic insulin resistance, and directly regulates
hepatic glucose production through the expression of Pck1 and G6pc [42]. The TCF7L2 mutant mice also
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displayed significant alterations in adipocyte size distribution in iWAT. This was already detectable in
younger mice with glucose intolerance, but without significant increases in iWAT mass, and further
progressed in 6 month old mice that had a 2 fold increase in iWAT mass. While the precise mechanisms
of adipocyte hypertrophy are unclear, it may reflect a combination of reduced hyperplasia and increased
lipid synthesis/storage, two processes that are reciprocally regulated in adipose tissue [43]. Increased lipid
synthesis/storage may be secondary to elevated Dgat2 expression, which we observed in adipocytes from
high fat fed E11 TCF7L2 mice. This enzyme is rate limiting for triglyceride synthesis in adipocytes, its
expression is closely correlated with hypertrophic adipocyte expansion [44; 45], and we previously have
shown that it is a direct transcriptional target of TCF7L2 [18]. A direct effect of TCF7L2 inactivation in
pre adipocytes in vivo is unlikely to contribute to the unhealthy adipose tissue expansion observed in
TCF7L2 mutant mice. Adiponectin is expressed in mature adipocytes only, and Adipo Cre mediated
recombination of the Tcf7l2 gene was not observed in the SVF. Thus, alternative mechanisms may
indirectly regulate ASC recruitment and differentiation in E11 TCF7L2 mice. In hypertrophic
adipocytes from TCF7L2 mutant mice we detected increased expression of Ccl2 and Cfh gene expression,
and CCL2 (MCP 1) inhibits adipocyte growth and differentiation [46]. Moreover, increased Axin2 mRNA
suggests increased adipocyte Wnt activity in hypertrophic adipocytes from E11 TCF7L2 mice. This
may be an additional mechanism regulating adipose tissue expansion in these mice as several Wnt ligands
have potent effects on adipogenesis in vitro and in vivo [47 50].
Interestingly we did not detect increased visceral (perigonadal) adipose tissue mass in E11
TCF7L2 mice. This is consistent with previous studies demonstrating that the Wnt pathway differentially
regulates adipose tissue depot formation [51], and may reflect the distinct developmental origins of these
fat compartments [52]. We also did not observe significant changes in energy balance in TCF7L2 mutant
mice. It is possible that long term energy balance analysis over the course of weeks or months, not
examined in the present study, may have revealed differences in energy balance in TCF7L2 mutant mice.
It is interesting that whole body heterozygote Tcf7l2 knockout mice have reduced fat mass, suggestive of
impaired adipogenesis, but improved glucose tolerance [53; 54]. However, the glucose tolerance in
17 Diabetes Page 18 of 79
whole body Tcf7l2 mutants may not reflect the role of TCF7L2 in adipose tissue alone, but rather
TCF7L2 action in alternative metabolic tissues [3]. Numerous studies have demonstrated that TCF7L2
regulates hepatic glucose metabolism [55; 56], β cell mass and insulin secretion [57].
In humans, the effect of the TCF7L2 risk allele on T2DM is modulated by obesity and T2DM prevalence is higher in non obese carriers [11; 12]. Moreover, TCF7L2 SNPs have been associated with obesity [58], but this association remains controversial and may be the result of ascertainment bias [59].
However, in a recent study, weight loss following gastric bypass surgery led to the differential expression
of TCF7L2 mRNA isoforms in subcutaneous fat [14]. Total TCF7L2 mRNA was unchanged, but an
adipose tissue specific variant incorporating exons 12 and 13 was increased following surgery.
Interestingly, in the same study, expression of a short TCF7L2 variant lacking exons 12 and 13 decreased
after weight loss, was more common in subcutaneous fat of patients with T2DM, and correlated positively
with FFA during insulin clamps [14]. In the present study we demonstrate that total TCF7L2 expression is
reduced by 20% in adipose tissue from subjects with IGT and adipose tissue insulin resistance. However,
we did not observe differential expression of TCF7L2 transcripts incorporating exon 12 and 13, as this
variant also was reduced in IGT adipose tissue. These data are consistent with a previous study
demonstrating reduced adipose tissue TCF7L2 mRNA in T2DM patients [60], and in carriers of the
TCF7L2 risk allele [61], and suggest that adipose tissue insulin sensitivity does not regulate TCF7L2 gene
splicing.
In conclusion, we show that TCF7L2 has important developmental and metabolic roles in adipose
tissue. Using a combination of in vitro and in vivo techniques in cells, rodents and humans we show that the regulation of adipogenesis by TCF7L2 and Wnt signaling is more complex than previously recognized, and that inactivation of adipocyte TCF7L2 in vivo promotes adipocyte hypertrophy, and peripheral and hepatic insulin resistance. Demonstrating the translational nature of our findings we also show that adipocyte insulin resistance in humans is associated with a reduction in TCF7L2 expression.
We hope that further study of TCF7L2 and Wnt signaling in adipose tissue will provide more insights into the function of this important T2DM candidate gene.
18 Page 19 of 79 Diabetes
Acknowledgements
This work was supported by National Institute of Health Grant KO1DK098314 (LN). LN planned the
studies, performed experiments, analyzed all raw data and wrote the manuscript. XC performed
experiments, analyzed data and reviewed/edited the manuscript, IA, CS, MF and NA researched data and
reviewed/edited the manuscript. SH performed computational analysis and reviewed/edited the
manuscript.. Dr. Luke Norton is the guarantor of this work and, as such, had full access to all the data in
the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We
would like to thank David H Wasserman, Owen McGuinness and Louise Lantier at Vanderbilt MMPC,
and Syann Lee at the Metabolic Core Unit at UT Southwestern Medical Center in Dallas for help in
phenotyping. These cores are supported, in part, by NIH grants DK059637 and DK88761, respectively.
Competing Interests
The authors declare no competing interests.
19 Diabetes Page 20 of 79
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Figure Legends
Figure 1: (A) Representative images of differentiating 3T3 L1 adipocytes at the time of induction (D0) and at D4 and D10 after initiation of adipogenesis (scale bar = 100 µm). (B and C) A representative Western blot of TCF7L2 during adipogenesis, examined using an antibody that recognizes an epitope around Leu331 and all variants of TCF7L2. The expression of the short (58 kDa) TCF7L2 protein isoform was higher than the long (78 kDa) isoform during adipogenesis. Total protein load, assessed by Ponceau S staining, was used for normalization (n = 5 independent experiments; ***P < 0.001 two way ANOVA Holm Sidak multiple comparison t test versus D0; †††P < 0.001 two way ANOVA main difference between isoform expression). (D) Total Tcf7l2 mRNA quantified by qRT PCR using a Taqman probe (assay ID: Mm00501505_m1) reached a nadir at D4 after induction of adipogenesis before recovering to baseline levels at day 8 (n = 3 independent experiments; one way ANOVA effect of time = P < 0.01; *P < 0.05 Holm Sidak multiple comparison t test versus D0). (E) Representative images of differentiating murine ASCs at D0, D2 and D6 after initiation of adipogenesis (scale bar = 100 µm). Representative Western blot of TCF7L2 demonstrates increased TCF7L2 protein during adipogenesis. The expression of the 58 kDa TCF7L2 protein was similar to the 78 kDa protein during adipogenesis (n = 5 independent experiments; ***P < 0.001 two way ANOVA Holm Sidak multiple comparison t test versus D0). (F) TCF7L2 silencing in 3T3 L1 cells (shTCF7L2) inhibited adipogenesis. A Western blot of TCF7L2 from three replicate shTCF7L2 D0 cells is shown to demonstrate the efficiency of TCF7L2 silencing. The differentiation capacity of shTCF7L2 pre adipocytes was assessed by triglyceride accumulation (n = 4 independent adipogenesis experiments; ***P < 0.001 t test versus shSCR). Note these triglyceride data also are included in Supplementary Fig 1 (shTCF7L2_A) for comparison with other stable shTCF7L2 clones.
Figure 2: GSEA Hallmark gene set enrichment (GSEA) from RNA Seq experiments carried out on shSCR and shTCF7L2 3T3 L1 cells in pre adipocytes (D0), and at multiple time points during adipogenesis (D2, D4, D6 and D8). Normalized enrichment scores (NES) from GSEA across all time points. The 50 Hallmark gene sets were hierarchically clustered in R using heatmap.2 from gplots and Euclidean distance to obtain the gene set ordering and the dendrogram used in the plot. The dot color indicates the time point and dot size the statistical significance (GSEA FDR), as indicated in the figure legend (NS, not significant; *P < 0.05; **P < 0.01; ***P < 0.001). Between the gene sets names and the plot, + and indicate whether the gene set had an FDR < 0.05 at any time point (+) or not ( ).
Figure 3: (A) The mRNA expression of Wnt genes Cttnb1, Axin2, Lef1, Myc, Wisp2 and Tle3 during adipogenesis in shTCF7L2 and shSCR control cells. (B) Representative Western blot and corresponding quantification for total and active β catenin protein during adipogenesis in shSCR and shTCF7L2 3T3 L1 cells (n = 3 independent experiments; *P < 0.05, **P < 0.01,***P < 0.001 two way ANOVA Holm Sidak multiple comparison t test versus D0; †††P < 0.001 two way ANOVA main effect of shTCF7L2; ^P < 0.05, ^^P < 0.01, ^^^P < 0.001 two way ANOVA time x shTCF7L2 interaction Holm Sidak multiple comparison t test versus corresponding shSCR time point). (C) Effect of IWR 1 treatment on total β catenin levels and adipogenesis in high passage shSCR and shTCF7L2 cells. Cells were treated with IWR 1 (10 µM) every other day for 6 days during differentiation. Western blot demonstrates the effect of IWR 1 on total β catenin protein levels at the end of adipogenesis (each lane represents a single independent adipogenesis experiment, n = 4 for each treatment). Triglycerides and the mRNA expression of Pparg, Lef1 and Axin2 were assessed by qRT PCR at the end of differentiation on D6 (n = 4 independent differentiation experiments; ***P < 0.001 two way ANOVA interaction Holm Sidak multiple comparison t test versus indicated controls).
Figure 4: (A) Schematic showing the targeting strategy for the mouse Tcf7l2 locus used in this study. (B) LoxP sites were placed around exon 11, which results in the deletion of exon 11, and not exon 6,
23 Diabetes Page 24 of 79
containing mRNA transcripts, as determined by qRT PCR on isolated adipocytes (n = 7, ***P < 0.001 Welch’s t test versus LoxP control mice). The exon 11 specific qRT PCR probe/primer combination was custom designed by Integrated DNA Technologies (Coralville, IA, USA). (C) To confirm deletion of exon 11 was specific to adipocytes, semi quantitative RT PCR was used to visualize Tcf7l2 transcripts in multiple tissues. Recombination of the Tcf7l2 locus occurred only in adipocytes and not the stromal vascular fraction (SVF) of adipose tissue. (D) Intraperitoneal glucose tolerance tests (IPGTT, n = 10 E11 TCF7L2, n = 12 LoxP controls; ^P < 0.05, ^^^P < 0.001 two way ANOVA time x Tcf7l2 genotype interaction Holm Sidak multiple comparison t test versus corresponding control time point). (E) Incremental area under the IPGTT curve (iAUC; **P < 0.01Welch’s t test) and (F) plasma insulin during the IPGTT (n = 7 E11 TCF7L2, n = 10 LoxP controls; ^P < 0.05 two way ANOVA time x genotype interaction Holm Sidak multiple comparison t test versus corresponding control time point). (G) Glucose infusion rate (GIR; ***P < 0.001 two way ANOVA main effect of Tcf7l2 genotype), (H) basal rate of glucose appearance (Ra) and glucose disappearance (Rd), and (I) residual insulin stimulated hepatic glucose production (rHGP; **P < 0.01 Mann Whitney test versus LoxP control mice) during low dose hyperinsulinemic euglycemic insulin clamps in male 3 month old chow fed mice (n = 10 E11 TCF7L2, n = 13 LoxP control mice for all clamp experiments).
Figure 5: (A) Cumulative weight gain, (B) absolute bodyweight (*P < 0.05 two way ANONA main effect of Tcf7l2 genotype), (C) final bodyweight (*P < 0.05 t test versus controls) and (D) cumulative food intake during and after 12 weeks HFD (n = 14 E11 TCF7L2, n = 16 LoxP controls). (E) IPGTT and (F) incremental area under the IPGTT curve (iAUC) following 12 weeks of HFD in male mice (n = 8 E11 TCF7L2, n = 8 control mice; ^P < 0.05, ^^^P < 0.001 two way ANOVA time x Tcf7l2 genotype interaction Holm Sidak multiple comparison t test versus corresponding control time point). (G) Liver triglyceride content was significantly elevated in E11 TCF7L2 mice (n = 8 E11 TCF7L2, n = 9 control mice, *P < 0.05 Mann Whitney test versus controls). (H) A representative H&E stain demonstrates increased lipid deposition in liver in TCF7L2 mutant mice at the end of 12 week HFD (scale bar = 100 µm).
Figure 6: (A) Inguinal white adipose tissue (iWAT) in male E11 TCF7L2 mice at 3 months and 6 months of age (n = 8 – 10 E11 TCF7L2, n = 8 – 10 control mice; **P < 0.01 Mann Whitney test versus control mice), and iWAT and perigonadal fat (pgWAT) following HFD (n = 12 E11 TCF7L2, n = 14 control mice; ***P < 0.001 t test versus control). Representative H&E stain and adipocyte size distribution performed on 3 month (B) and 6 month (C) iWAT (scale bar = 100 µm). (D) Average adipocyte area in 3 month (n = 6 E11 TCF7L2, n = 7 control mice) and (E) 6 month old mice (n = 8 E11 TCF7L2, n = 8 control mice) calculated using Adiposoft (**P < 0.01 Welch’s t test versus control). (F) Total number of adipocytes counted in an equal number of histological sections in 6 month old mice (**P < 0.01 t test versus control). (G) Correlation between iWAT weight and adipocyte area in 6 month old mice.
Figure 7: (A) Plasma glucose and (B) insulin during an oral glucose tolerance test (OGTT) in human subjects with normal glucose tolerance (NGT, n = 21) or impaired glucose tolerance (IGT, n = 22) (^^P < 0.05, ^^^P < 0.001 two way ANOVA time x NGT/IGT phenotype interaction Holm Sidak multiple comparison t test versus corresponding NGT time point). (C) BMI was similar between the two groups. (D) Adipose tissue insulin resistance (Adipo IR) was higher in IGT subjects (*P < 0.05 t test versus NGT). (E) Subcutaneous adipose tissue total TCF7L2 mRNA (exon 10 – 11; assay ID: Hs01009038_m1), and a short TCF7L2 mRNA variant incorporating exons 12 and 13 (F) were lower in IGT subjects with adipose tissue insulin resistance.
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A Day 0 Day 4 Day 10
B D0 D2 D4 D6 D8 D10 75 TCF7L2 50
50 Ponceau S
C LONG SHORT (78 kDa) (58 kDa) D *** ††† *** *
E F shSCR shTCF7L2 Day 0 Day 2 Day 6
D0 D2 D4 D6 shSCR shTCF7L2 75 75 TCF7L2 TCF7L2 50 50 50 Tubulin 50 Tubulin
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Supplementary Figure 1: (A) Multiple shRNA sequences targeting various regions of Tcf7l2 mRNA were used to confirm that silencing of TCF7L2 inhibited adipogenesis, as shown by triglyceride accumulation in multiple clones of shTCF7L2 3T3 L1 cells (B) (n = 4 independent experiments for each stable clone; ***P < 0.001 one way ANOVA Holm Sidak multiple comparison t test versus shSCR control). (C) Protein content and cell number at the induction of adipogenesis on D0 was not different between shSCR and shTCF7L2 (shown is data for shTCF7L2_A).
Supplementary Figure 2: (A) Representative Western blots and corresponding quantitation for adipogenic transcription factor protein levels during adipogenesis in shSCR and shTCF7L2 3T3 L1 cells. (B) mRNA expression of adipogenic transcription factors during adipogenesis in shSCR and shTCF7L2 3T3 L1 cells (n = 3 independent experiments; ***P < 0.001 two way ANOVA Holm Sidak multiple comparison t test versus D0; †P < 0.05 two way ANOVA main effect of shTCF7L2; ^P < 0.05, ^^P < 0.01, ^^^P < 0.001 two way ANOVA time x shTCF7L2 interaction Holm Sidak multiple comparison t test versus corresponding shSCR time point).
Supplementary Figure 3: (A) Representative Western blot of insulin stimulated phosphorylation of Akt in shSCR and shTCF7L2 cells. (B) Insulin stimulated glucose uptake (n = 4 independent experiments; ***P < 0.001 t test versus shSCR) and Slc2a4 mRNA expression (n = 3 independent experiments; ^^P < 0.01 two way ANOVA time x shTCF7L2 interaction Holm Sidak multiple comparison t test versus corresponding shSCR time point).
Supplementary Figure 4: mRNA expression of key inflammatory and metabolic genes in shTCF7L2 cells. The RNA Seq data was generated in clone A and the above qRT PCR data was generated in clone B (see Supplementary Fig 1). Analysis was performed using Biogazelle Qbase+. (n = 3 independent experiments; **P < 0.01, ***P < 0.001 t test versus shSCR).
Supplementary Figure 5: Bodyweight [A (rounded to nearest number) and J], food intake (B and K) and Leptin levels (C and L) for 3 month old female and male mice. (D and E) NMR analysis of total lean and fat mass, and (F – H) metabolic cage analysis is shown for female mice and includes assessment of total movement, respiratory exchange ratio (RER) and energy expenditure during dark and light cycles. (I) Net energy balance is calculated for female mice. (M) Liver triglyceride quantification of shown for male 3 month old mice (n = 5 – 12 E11 TCF7L2, n = 6 – 11 LoxP controls; *P < 0.05 t test versus control mice).
Supplementary Figure 6: (A) Intraperitoneal glucose tolerance tests (IPGTT, n = 9 E11 TCF7L2, n = 8 LoxP controls; ^^^P < 0.001 two way ANOVA time x Tcf7l2 genotype interaction Holm Sidak multiple comparison t test versus corresponding control time point). (B) Incremental area under the IPGTT curve (iAUC; ***P < 0.001 t test). (C and D) Insulin tolerance tests (ITT) for female (n = 8 E11 TCF7L2, n = 12 LoxP controls) and male (n = 8 E11 TCF7L2, n = 7 LoxP controls) mice (^P < 0.05, ^^P < 0.01 two way ANOVA time x Tcf7l2 genotype interaction Holm Sidak multiple comparison t test versus corresponding control time point; *P < 0.05 two way ANONA main effect of Tcf7l2 genotype)
Supplementary Figure 7: (A) Gene expression of hepatic gluconeogenic genes at the end of insulin clamp experiments, and (B) gene expression of hepatic lipogenic genes in the fasted state. Both were from 3 month old chow fed mice (*P < 0.05, **P < 0.01 t test versus control mice, corrected for multiple comparisons using Holm Sidak method)
Supplementary Figure 8: Bodyweight (A) and food intake (B) in 6 month old male mice. (C and D) NMR analysis of total lean and fat mass. (E – H) Metabolic cage analysis and net energy expenditure is shown for 6 month old male mice. (I) (n = 7 – 10 E11 TCF7L2, n = 8 – 10 LoxP controls). *P < 0.05 t test versus control mice. Page 33 of 79 Diabetes
Supplementary Figure 9: Gene expression of Axin2, Ccl2, Dgat2, Cfh and Pparg in isolated adipocytes from male iWAT following HFD (n = 6 E11 TCF7L2, n = 8 control mice; *P < 0.05, **P < 0.01 t test versus control)
Diabetes Page 34 of 79
Supplementary Fig 1
A
***
B
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Supplementary Fig 2
A shSCR shTCF7L2
*** † *** *** ^ ^^^ ***
^^^ ^^ ^^^
B
^^ ^^ ^^^
^^ ^^
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Supplementary Fig 3
A shSCR shTCF7L2 Insulin - - - + + + - - - + + + pAkt473
Total Akt
Ponceau-S
B
*** ^^
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Supplementary Fig 4
*** ** ***
***
*** **
***
***
**
***
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Supplementary Fig 5
A B C Female * *
D E F *
G H I
J K L
Male
M
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Supplementary Fig 6
A B Female Female
^^^ *** ^^^ ^^^
C Female D Male
^ ^ ^^
*
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Supplementary Fig 7
A
**
* *
B
*
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Supplementary Fig 8
A B * *
C D *
E F G * *
*
H
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Supplementary Fig 9
* ** **
*
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Supplementary Table 1: Clinical characteristics of human patients used in the present study
(corresponds to Figure 7)
NGT IGT p
n 21 22
Sex (M/F) 4/17 8/14
Age (years) 47 ± 2 49 ± 2 0.42
BMI (kg/m2) 31.3 ± 1.6 33.7 ± 1.5 0.26
Fasting Glucose (mg/dL) 92.6 ± 1.4 103.7 ± 1.6 < 0.001
2h Glucose (mg/dL) 107.7 ± 5.8 160.9 ± 4 < 0.001
Fasting Insulin (mU/L) 5.0 ± 0.7 6.6 ± 0.6 0.09
2h Insulin (mU/L) 42.2 ± 7.4 81.8 ± 11.3 < 0.01
Fasting FFA (mmol/L) 0.49 ± 0.03 0.56 ± 0.04 0.18
1h FFA (mmol/L) 0.13 ± 0.02 0.20 ± 0.02 < 0.05 Diabetes Page 44 of 79
Supplemental Date: Differentially expressed genes during 3T3-L1 differentiation upon shRNA-mediated silencing of Tcf7l2
## timepoint: day of differentiation ## gene_name: official mouse gene symbol (from original transcriptome gtf) ## gene_id: ENSEMBL gene id (from original transcriptome gtf) ## baseMean: mean absolute expression for the treatment group (from DESeq2 stats) ## log2FC: log2 transformed fold change for treatment over control (from DESeq2 stats) ## lfcSE: standard error for logFC (from DESeq2 stats) ## stat: Wald test statistic (from DESeq2 stats) ## pvalue: p-value (from DESeq2 stats) ## padj: adjusted p-value (from DESeq2 stats) ## mean_shS: group-wise mean of expression in group shScramble (calculated from vst normalized expression) ## mean_shT: group-wise mean of expression in group shTcf7l2 (calculated from vst normalized expression) timepoint gene_name gene_id baseMean log2FC lfcSE stat pvalue padj mean_shS mean_shT 0 2010002M12Rik ENSMUSG00000067297.4 207.5842031 0.987175764 0.222821167 4.430350036 9.41E-06 0.001638086 7.118764774 8.736217982 0 3110039M20Rik ENSMUSG00000089922.1 29.45064393 0.840505456 0.208628688 4.028714673 5.61E-05 0.006442103 6.253662792 7.190950931 0 4930528F23Rik ENSMUSG00000024155.7 33.04856764 0.765556864 0.219100569 3.494088887 0.000475683 0.032648407 6.473118225 7.213473788 0 5930403N24Rik ENSMUSG00000046463.3 148.3376996 -0.850788431 0.221065139 -3.848587055 0.000118801 0.011424934 8.307901962 7.507997291 0 9130208D14Rik ENSMUSG00000086513.1 360.4819664 1.296051001 0.2278934 5.687093173 1.29E-08 5.78E-06 7.787789425 9.401503525 0 Abcb1b ENSMUSG00000028970.5 459.5164507 0.924754336 0.194627309 4.751410998 2.02E-06 0.000470608 8.5898084 9.553420742 0 Abi3bp ENSMUSG00000035258.7 330.7894866 -0.994525562 0.21840603 -4.553562755 5.27E-06 0.000980285 9.220188208 8.090860311 0 Actn3 ENSMUSG00000006457.3 177.0181394 -0.968518522 0.223658261 -4.330349867 1.49E-05 0.00236779 8.524316984 7.544290039 0 Adam12 ENSMUSG00000054555.5 2116.438245 -1.171612099 0.191883885 -6.105838948 1.02E-09 7.35E-07 11.64938479 10.24385041 0 Add3 ENSMUSG00000025026.8 1731.998518 -1.305244319 0.199952833 -6.527761063 6.68E-11 6.50E-08 11.41898042 9.823632623 0 AI646023 ENSMUSG00000046807.8 487.8881974 -1.160105496 0.199569096 -5.813051825 6.13E-09 3.62E-06 9.711886207 8.466406005 0 Alcam ENSMUSG00000022636.7 2309.704315 0.683304743 0.167552788 4.078146055 4.54E-05 0.005603726 10.80721205 11.57786823 0 Angptl4 ENSMUSG00000002289.9 1431.105979 -0.796005306 0.210554126 -3.780525799 0.000156498 0.014068615 11.00366538 9.956796476 0 Anpep ENSMUSG00000039062.8 1659.260842 -0.860670168 0.2208464 -3.897143756 9.73E-05 0.009877296 11.2291505 10.01439496 0 Anxa8 ENSMUSG00000021950.9 710.0255352 -0.794848651 0.220109379 -3.611153035 0.000304839 0.023236576 10.05928685 9.058054864 0 Apba1 ENSMUSG00000024897.7 1104.872996 -0.669829461 0.196562453 -3.407718259 0.000655085 0.041907458 10.58618126 9.789819084 0 Apol9a ENSMUSG00000068246.4 302.9207157 0.918493456 0.229951006 3.994300659 6.49E-05 0.007301162 7.85864153 9.126603081 0 Apol9b ENSMUSG00000057346.4 304.7776845 0.858909895 0.229801233 3.737620917 0.00018577 0.015971436 7.81572514 9.135373609 0 Aqp1 ENSMUSG00000004655.5 3294.297704 -1.022821629 0.199039296 -5.13879243 2.77E-07 8.47E-05 12.2342185 10.92029763 0 Arhgap44 ENSMUSG00000033389.9 245.8514894 -0.688897818 0.204122355 -3.374925876 0.000738356 0.045742107 8.754668365 8.089026546 0 Arrdc4 ENSMUSG00000042659.8 451.8519481 -1.002850574 0.201204114 -4.984244861 6.22E-07 0.000171487 9.567468382 8.494381956 0 BC005764 ENSMUSG00000035835.7 169.5457953 -0.917564278 0.218082315 -4.207421765 2.58E-05 0.003620808 8.461754915 7.581674111 0 BC006779 ENSMUSG00000027580.10 1912.316532 0.767138769 0.220209924 3.483670294 0.000494588 0.03366661 10.30454115 11.37589022 0 Bche ENSMUSG00000027792.5 44.38127562 1.355898254 0.219505718 6.177052092 6.53E-10 5.14E-07 5.987329882 7.522141416 0 Bcl11b ENSMUSG00000048251.9 89.0801961 -0.854272982 0.227984162 -3.747071614 0.000178911 0.015575617 7.867820699 7.108400969 0 Boc ENSMUSG00000022687.5 2878.825473 -0.634340149 0.172678599 -3.673530778 0.000239222 0.01911579 11.8666484 11.13339802 0 Bst2 ENSMUSG00000046718.7 2808.138658 0.997248609 0.227347684 4.386447184 1.15E-05 0.001908247 10.40643374 12.03169788 0 C130026I21Rik ENSMUSG00000052477.9 179.1705927 0.797367393 0.213567994 3.733552851 0.000188798 0.016097424 7.72073246 8.46946142 0 C4b ENSMUSG00000073418.4 72.79412269 -0.785578581 0.230114095 -3.41386555 0.000640482 0.041222601 7.704474995 6.966177136 0 C920025E04Rik ENSMUSG00000073405.5 1101.43046 0.719813403 0.18996575 3.789174641 0.000151149 0.013742957 9.765308394 10.59904718 0 Cacna1g ENSMUSG00000020866.10 3104.722945 -1.293951029 0.192811069 -6.71097897 1.93E-11 2.13E-08 12.22367193 10.63746129 0 Ccdc8 ENSMUSG00000041117.7 391.6252536 -0.759035755 0.1939282 -3.914004027 9.08E-05 0.009384756 9.301377854 8.532041968 0 Ccdc85a ENSMUSG00000032878.10 37.96160242 1.190680196 0.216509575 5.49943437 3.81E-08 1.50E-05 6.037558263 7.407224615 0 Ccl2 ENSMUSG00000035385.5 717.2007562 1.216871128 0.222737427 5.463253942 4.67E-08 1.80E-05 8.624475553 10.2511566 0 Ccl5 ENSMUSG00000035042.2 64.00652453 0.781785349 0.230031694 3.398598411 0.000677321 0.042599107 6.919977462 7.602326088 0 Ccl7 ENSMUSG00000035373.2 637.4776702 1.115693228 0.227511348 4.903901451 9.40E-07 0.000250654 8.466390581 10.10976188 0 Cd274 ENSMUSG00000016496.7 149.1381568 0.795246128 0.229408295 3.466509911 0.000527262 0.035309496 7.45617096 8.307080014 0 Cd74 ENSMUSG00000024610.8 284.8155115 1.189902862 0.207417094 5.736763737 9.65E-09 4.84E-06 7.898428864 9.081438138 0 Cdo1 ENSMUSG00000033022.7 945.9486987 -0.764327315 0.211981086 -3.605639208 0.000311386 0.023411944 10.42655425 9.468197522 0 Cdsn ENSMUSG00000039518.7 4784.713321 0.652832163 0.166418076 3.92284406 8.75E-05 0.009107353 11.83183729 12.5868726 0 Cfh ENSMUSG00000026365.9 1233.805576 3.425145065 0.210446161 16.27563574 1.47E-59 2.43E-55 7.365224902 11.29118981 0 Cfhr2 ENSMUSG00000033898.10 109.2019664 2.26361283 0.229283791 9.872537542 5.48E-23 2.26E-19 6.340092128 8.310307446 0 Chac1 ENSMUSG00000027313.3 473.2961735 0.736448018 0.211653933 3.479491294 0.000502367 0.034055932 8.680734478 9.547239139 0 Chst8 ENSMUSG00000060402.6 89.94171289 -1.203452611 0.227170865 -5.297565816 1.17E-07 3.96E-05 7.961505719 6.935625055 0 Cib2 ENSMUSG00000037493.6 348.8429438 -0.825498763 0.204594949 -4.034795415 5.46E-05 0.006365943 9.203794319 8.335420568 0 Clcn3 ENSMUSG00000004319.9 741.7594462 0.72630678 0.191782799 3.787132025 0.000152396 0.013774778 9.274056505 10.08136684 0 Cmpk2 ENSMUSG00000020638.7 234.4934214 1.010114739 0.217713292 4.639655796 3.49E-06 0.000707411 6.991553468 8.819350928 0 Cnksr3 ENSMUSG00000015202.7 582.087493 -0.640804982 0.18679956 -3.430441598 0.0006026 0.039242525 9.73510963 9.059121331 0 Col15a1 ENSMUSG00000028339.11 2356.103814 -1.056029272 0.203461959 -5.190303283 2.10E-07 6.68E-05 11.77069358 10.4262233 0 Cpxm1 ENSMUSG00000027408.7 146.2744889 -1.065117055 0.224430693 -4.745861803 2.08E-06 0.000473554 8.368928334 7.336681357 0 Csmd1 ENSMUSG00000060924.7 32.40732714 0.8202002 0.19307979 4.247985776 2.16E-05 0.003245984 5.86557738 7.240296648 0 Cxcl10 ENSMUSG00000034855.7 158.5875193 0.944073743 0.210096125 4.493532394 7.01E-06 0.00126962 6.658657788 8.379728827 0 Cxcl12 ENSMUSG00000061353.5 31527.01431 -0.668682734 0.194234097 -3.442664009 0.000576014 0.038264479 15.30950822 14.4353537 0 Cyb5r1 ENSMUSG00000026456.11 3268.206042 0.640354507 0.17406866 3.678746698 0.000234383 0.018820037 11.30245943 12.04599542 0 Cyp26b1 ENSMUSG00000063415.5 364.8435732 -0.749355577 0.201721032 -3.714811334 0.000203355 0.016968647 9.223787564 8.440605859 0 D14Ertd668e ENSMUSG00000068245.7 296.8521158 0.983255904 0.229994086 4.275135592 1.91E-05 0.00295297 7.720113823 9.101906427 0 Daam2 ENSMUSG00000040260.7 1324.672066 -1.268626805 0.176111383 -7.203548033 5.87E-13 1.08E-09 11.02749984 9.621136502 0 Dach2 ENSMUSG00000025592.10 34.97513378 0.762549076 0.216909664 3.515514538 0.000438903 0.03050374 6.46780657 7.245062701 0 Dapk1 ENSMUSG00000021559.7 73.30401964 -0.777647084 0.230035611 -3.380550869 0.000723407 0.045154235 7.702895565 6.971143468 0 Dhx58 ENSMUSG00000017830.8 512.4123583 0.870061089 0.224517169 3.87525415 0.000106513 0.01051636 8.578359989 9.690464126 0 Disp2 ENSMUSG00000040035.7 87.7630556 -0.777827478 0.228301887 -3.40701292 0.00065678 0.041907458 7.837211036 7.134132592 0 Dlk1 ENSMUSG00000040856.11 97394.64895 -0.636030898 0.161253479 -3.944292563 8.00E-05 0.008541121 16.89688744 16.15483277 0 Dmd ENSMUSG00000045103.10 68.90993835 1.603399254 0.229962382 6.972441485 3.11E-12 4.29E-09 6.431960183 7.842268569 0 Dnm3os ENSMUSG00000078190.4 4653.483478 -0.673820789 0.186872711 -3.605774145 0.000311224 0.023411944 12.57462542 11.73178449 0 Dtna ENSMUSG00000024302.8 411.3075143 0.75531907 0.194942353 3.874576554 0.00010681 0.01051636 8.58362042 9.359270748 0 Ecm1 ENSMUSG00000028108.8 3300.100859 0.672293109 0.169773676 3.959937283 7.50E-05 0.008158353 11.29727499 12.07359665 0 Emilin2 ENSMUSG00000024053.9 78.44143045 -0.899243034 0.229160206 -3.924080233 8.71E-05 0.009107353 7.783838083 6.99071506 0 Emx2 ENSMUSG00000043969.3 193.6066275 0.758021386 0.213299393 3.553790641 0.000379721 0.027427821 7.803536551 8.539310151 0 Enpp2 ENSMUSG00000022425.9 5167.540955 1.068360221 0.185269524 5.766518952 8.09E-09 4.18E-06 11.56487962 12.86870515 0 Epas1 ENSMUSG00000024140.9 304.3293988 -1.008230331 0.207683538 -4.85464733 1.21E-06 0.000306902 9.104103711 8.07604819 Page 45 of 79 Diabetes
0 Ero1l ENSMUSG00000021831.7 5290.714356 0.863734296 0.163824399 5.272317811 1.35E-07 4.37E-05 11.82103345 12.81242074 0 Etv4 ENSMUSG00000017724.8 139.2086366 0.813862603 0.226105682 3.599478769 0.000318856 0.023651083 7.435040089 8.258635539 0 Ext1 ENSMUSG00000061731.3 4662.61284 -0.602393744 0.17894393 -3.366382674 0.00076161 0.046684757 12.53717734 11.8096895 0 F11r ENSMUSG00000038235.4 71.21885425 0.821004684 0.229316107 3.580231219 0.00034329 0.025234441 6.881590554 7.723753492 0 Fabp4 ENSMUSG00000062515.2 99.69580573 -0.90446945 0.225696957 -4.007450789 6.14E-05 0.006971208 8.03716393 6.887112376 0 Fam135b ENSMUSG00000036800.7 89.29053974 -0.918568494 0.227215438 -4.042720439 5.28E-05 0.006201532 7.885434093 7.084746659 0 Fam20c ENSMUSG00000025854.9 1648.341804 -0.627592567 0.174663551 -3.59315131 0.000326703 0.024124956 11.09440757 10.38388508 0 Fam84b ENSMUSG00000072568.3 25.39517665 0.758668856 0.200183755 3.789862257 0.000150731 0.013742957 6.092686759 7.131785787 0 Fat2 ENSMUSG00000055333.7 36.81072897 -0.907132014 0.220002112 -4.123287749 3.74E-05 0.004795394 7.312904519 6.418351925 0 Fbln5 ENSMUSG00000021186.8 1586.60725 -0.718420358 0.177712802 -4.042592046 5.29E-05 0.006201532 11.0829787 10.26293339 0 Fgfr2 ENSMUSG00000030849.10 1725.433267 -1.10666691 0.18762011 -5.898445065 3.67E-09 2.33E-06 11.34435567 10.0491138 0 Fgfr3 ENSMUSG00000054252.9 190.7666246 -1.424431613 0.222065438 -6.414467867 1.41E-10 1.30E-07 8.721342905 7.319245247 0 Fgfrl1 ENSMUSG00000008090.8 2498.030575 -0.616730329 0.174296053 -3.53840674 0.000402549 0.028679421 11.66364818 10.94855943 0 Fhod3 ENSMUSG00000034295.8 56.56084007 0.772967225 0.212585617 3.636027857 0.000276874 0.021400839 6.520570688 7.595849566 0 Foxo6 ENSMUSG00000052135.7 518.2147982 -0.859166108 0.185319078 -4.63614495 3.55E-06 0.000707411 9.672366634 8.787313017 0 Fxyd1 ENSMUSG00000036570.7 108.2968822 -0.827431379 0.228410736 -3.622559045 0.000291703 0.022442125 8.038806285 7.226792385 0 Fxyd5 ENSMUSG00000009687.8 566.0746936 -1.092045788 0.188560398 -5.791490682 6.98E-09 3.86E-06 9.862342974 8.717705631 0 Gap43 ENSMUSG00000047261.9 20.37362734 0.784231794 0.198230432 3.956162457 7.62E-05 0.008218805 6.094630726 7.005441628 0 Gbp10 ENSMUSG00000054588.7 1038.269367 0.882776803 0.229306169 3.849773451 0.000118227 0.011424934 9.205157825 10.63827405 0 Gbp11 ENSMUSG00000092021.1 129.4195688 0.834332649 0.228280904 3.654850815 0.000257332 0.020077932 7.353711807 8.186108814 0 Gbp3 ENSMUSG00000028268.8 590.236239 1.141058873 0.225257747 5.065569955 4.07E-07 0.000118161 8.453879771 9.971586472 0 Gbp4 ENSMUSG00000079363.2 297.0503832 1.413461972 0.229930488 6.147344712 7.88E-10 5.92E-07 7.400716711 9.211562074 0 Gbp6 ENSMUSG00000079362.2 1420.537755 0.929518612 0.226892305 4.096739245 4.19E-05 0.005290726 9.625686892 11.06843482 0 Gbp7 ENSMUSG00000040253.9 1335.651193 0.972982229 0.212155631 4.586172058 4.51E-06 0.000878515 9.721724469 10.95838291 0 Gbp8 ENSMUSG00000034438.9 160.8636036 1.009598245 0.229029239 4.408163113 1.04E-05 0.001777749 7.358097522 8.458971044 0 Gbp9 ENSMUSG00000029298.8 610.7763093 1.531463744 0.224965417 6.807551854 9.93E-12 1.26E-08 8.122630928 10.10676588 0 Gda ENSMUSG00000058624.6 948.4545587 -0.605678759 0.176060215 -3.440179602 0.000581328 0.038463004 10.34352972 9.685923091 0 Gdf10 ENSMUSG00000021943.5 60.13272351 -1.6461897 0.229128124 -7.184581591 6.74E-13 1.12E-09 7.752045431 6.296331341 0 Gja1 ENSMUSG00000050953.8 656.1817591 0.679743409 0.185417272 3.6660199 0.000246355 0.019404544 9.174934211 9.901724342 0 Gm10499 ENSMUSG00000073403.4 676.1648557 0.791962961 0.19489517 4.063533029 4.83E-05 0.005896798 9.10599098 9.994871692 0 Gm11127 ENSMUSG00000079492.2 1207.581988 0.817312357 0.189909694 4.303689494 1.68E-05 0.002621234 9.809176814 10.76100578 0 Gm12250 ENSMUSG00000082292.2 119.9139416 0.759341678 0.2145723 3.538861627 0.000401856 0.028679421 6.930100291 8.088525736 0 Gm14446 ENSMUSG00000079339.6 73.39274512 0.920057673 0.219763352 4.186583736 2.83E-05 0.003903462 6.626136269 7.777678074 0 Gm16332 ENSMUSG00000089991.1 140.2048682 2.515402616 0.227566293 11.05349381 2.11E-28 1.16E-24 6.363626692 8.569165281 0 Gm16340 ENSMUSG00000090222.1 472.8541205 0.863958617 0.225071161 3.838602038 0.000123737 0.011796976 8.490738527 9.591986352 0 Gm17782 ENSMUSG00000092366.1 485.4979841 0.771171524 0.205671973 3.749521697 0.000177172 0.015575617 8.712223512 9.58122178 0 Gm2619 ENSMUSG00000091199.1 81.91666766 0.859400889 0.229483912 3.744928709 0.000180445 0.015626916 7.025220457 7.811186113 0 Gm4070 ENSMUSG00000078606.1 1852.652272 1.307078269 0.228779497 5.713266648 1.11E-08 5.39E-06 9.433679573 11.51877044 0 Gm4788 ENSMUSG00000070594.4 128.9619876 2.708537371 0.22805084 11.87690152 1.56E-32 1.29E-28 6.189165325 8.500004201 0 Gm4902 ENSMUSG00000091649.1 102.4936693 0.909940944 0.229711138 3.96123998 7.46E-05 0.008158353 7.040101346 8.019552219 0 Gm4951 ENSMUSG00000073555.1 156.3986112 0.919554217 0.223030824 4.12299161 3.74E-05 0.004795394 7.060774376 8.407891618 0 Gm5834 ENSMUSG00000085867.1 19.29199229 0.828870246 0.199960426 4.145171436 3.40E-05 0.004493324 6.059021277 6.992973221 0 Gm7582 ENSMUSG00000061852.8 111.0796519 0.876222873 0.228308499 3.837889856 0.000124096 0.011796976 7.21606179 8.072188838 0 Gm7592 ENSMUSG00000090186.3 410.3516171 0.821257442 0.227333578 3.612565509 0.000303182 0.023217321 8.333284502 9.424546619 0 Gm7609 ENSMUSG00000079457.3 201.5712737 0.790271471 0.230028941 3.435530627 0.000591395 0.038818485 7.633769249 8.632448937 0 Gm8815 ENSMUSG00000092224.1 551.4214784 0.800873206 0.201132481 3.981819356 6.84E-05 0.007643479 8.848874564 9.744485499 0 Gm8979 ENSMUSG00000091928.1 201.8187837 0.95356551 0.226290659 4.213896927 2.51E-05 0.003579157 7.271416941 8.680209629 0 Gm8989 ENSMUSG00000091567.1 201.8187837 0.95356551 0.226290659 4.213896927 2.51E-05 0.003579157 7.271416941 8.680209629 0 Gm9574 ENSMUSG00000073980.3 587.0288876 0.777022209 0.203978746 3.809329276 0.000139344 0.013021999 8.923328177 9.819471912 0 Gpr149 ENSMUSG00000043441.5 710.5906136 0.805665795 0.225102859 3.579100671 0.000344779 0.025234441 8.963948501 10.10606682 0 Gpr155 ENSMUSG00000041762.8 558.098447 -0.903413776 0.190113464 -4.751971561 2.01E-06 0.000470608 9.782511307 8.829639381 0 Gpr30 ENSMUSG00000053647.4 202.6631168 -1.109920143 0.208602696 -5.3207373 1.03E-07 3.56E-05 8.684297127 7.65853663 0 Grem2 ENSMUSG00000050069.3 803.7419778 -0.764205096 0.217546486 -3.512835857 0.000443351 0.03068399 10.25076102 9.209993375 0 Gria3 ENSMUSG00000001986.9 104.2378938 1.169960351 0.225674569 5.184280862 2.17E-07 6.77E-05 7.054022961 8.079373334 0 Gsdmd ENSMUSG00000022575.4 179.5385778 1.237050419 0.222443527 5.561188658 2.68E-08 1.11E-05 7.395247792 8.609804514 0 Gvin1 ENSMUSG00000045868.5 1825.59924 1.303792408 0.228757195 5.699459668 1.20E-08 5.52E-06 9.422085734 11.49748285 0 H2-Bl ENSMUSG00000073406.2 531.4274118 0.80903306 0.198148537 4.082962561 4.45E-05 0.005541618 8.813368788 9.69716481 0 H2-D1 ENSMUSG00000073411.4 8167.437481 0.769587891 0.181684506 4.235847664 2.28E-05 0.003362713 12.4631655 13.40677513 0 H2-K1 ENSMUSG00000061232.8 4261.684712 0.920790635 0.193462285 4.759535616 1.94E-06 0.000470608 11.39195368 12.55040781 0 H2-K2 ENSMUSG00000067203.6 804.7609586 0.808806358 0.189442661 4.269399264 1.96E-05 0.003001887 9.318303015 10.2180536 0 H2-Q10 ENSMUSG00000067235.7 937.9930503 0.754649812 0.20194916 3.736830653 0.000186354 0.015971436 9.502176375 10.41088735 0 H2-Q4 ENSMUSG00000035929.10 1033.083433 0.854612869 0.210636822 4.057281443 4.96E-05 0.00599427 9.50774415 10.57771747 0 H2-Q6 ENSMUSG00000073409.5 1130.215456 0.85368071 0.195786247 4.360269041 1.30E-05 0.002106588 9.679118261 10.69136816 0 H2-Q7 ENSMUSG00000060550.8 1180.45806 0.789699776 0.198798145 3.972369942 7.12E-05 0.007899836 9.772329544 10.72781785 0 H2-Q8 ENSMUSG00000055413.9 251.8173133 0.770994831 0.204683728 3.766761721 0.000165379 0.014707146 8.059342492 8.811620439 0 H2-T22 ENSMUSG00000056116.11 2050.891712 0.653930844 0.17700131 3.694497201 0.000220322 0.01795247 10.65135322 11.40744761 0 H2-T23 ENSMUSG00000067212.7 1480.997143 0.780625041 0.185534449 4.207439879 2.58E-05 0.003620808 10.11085814 11.01845859 0 Hbegf ENSMUSG00000024486.5 70.50835977 0.871856891 0.229777402 3.794354372 0.000148028 0.013678957 6.933782447 7.695810209 0 Herc6 ENSMUSG00000029798.8 769.2938253 0.790234169 0.226803592 3.484222453 0.000493569 0.03366661 9.067103281 10.16970753 0 Hey1 ENSMUSG00000040289.3 75.55946737 -0.87604852 0.229593406 -3.815651913 0.000135824 0.012765128 7.77362042 6.889619415 0 Hmga1 ENSMUSG00000046711.9 3718.78775 0.744640957 0.167406977 4.448087947 8.66E-06 0.001540946 11.41356753 12.26964684 0 Hs6st2 ENSMUSG00000062184.5 695.2781012 0.731933696 0.18070599 4.050411912 5.11E-05 0.006117072 9.216835015 9.993490549 0 Hspa4l ENSMUSG00000025757.7 536.2302912 0.905735952 0.192245238 4.711357012 2.46E-06 0.000535564 8.77427352 9.738080984 0 Ica1 ENSMUSG00000062995.5 125.2291749 0.739997191 0.219792659 3.36679667 0.000760467 0.046684757 7.452027256 8.113170686 0 Id4 ENSMUSG00000021379.1 191.5064261 -1.08681716 0.217457672 -4.997833138 5.80E-07 0.000162545 8.629339369 7.579283678 0 Ifi202b ENSMUSG00000026535.8 1947.185386 0.678621646 0.181045512 3.748348353 0.000178003 0.015575617 10.55711558 11.34835259 0 Ifi203 ENSMUSG00000039997.10 2296.383787 0.822814352 0.228027033 3.60840705 0.000308083 0.02337614 10.34915575 11.66001836 0 Ifi204 ENSMUSG00000073489.3 1670.087782 0.745957886 0.193166245 3.861740364 0.000112582 0.011019064 10.28089713 11.16608819 0 Ifi205 ENSMUSG00000054203.6 145.0821112 0.826230523 0.229406597 3.601598787 0.000316266 0.023564681 7.41219436 8.293912281 0 Ifi27l2a ENSMUSG00000079017.3 195.5172613 0.865206787 0.230109967 3.759970934 0.000169933 0.015031355 7.54168914 8.620728132 0 Ifi35 ENSMUSG00000010358.7 628.9377394 0.790918779 0.199976945 3.955049816 7.65E-05 0.008218805 9.015005964 9.899459116 0 Ifi44 ENSMUSG00000028037.7 1112.940101 1.246240094 0.228372742 5.457043965 4.84E-08 1.82E-05 8.916143666 10.84039703 0 Ifih1 ENSMUSG00000026896.7 268.9777197 0.775740777 0.229751951 3.376427373 0.000734338 0.045664202 7.931482722 8.89851957 0 Ifit2 ENSMUSG00000045932.6 730.5110645 0.914175115 0.22815259 4.006858372 6.15E-05 0.006971208 8.85497399 10.14582719 0 Igf1 ENSMUSG00000020053.11 3152.394034 -0.71448269 0.192732639 -3.707118289 0.000209631 0.017305265 12.0409379 11.15246606 0 Iglon5 ENSMUSG00000013367.4 561.1212173 -0.717690658 0.210986833 -3.401589792 0.000669951 0.04229642 9.739774085 8.894337647 Diabetes Page 46 of 79
0 Igtp ENSMUSG00000078853.2 821.4910169 1.339308247 0.223159894 6.00156337 1.95E-09 1.29E-06 8.662366082 10.43608436 0 Iigp1 ENSMUSG00000054072.5 663.2052228 1.05055247 0.230125122 4.565135952 4.99E-06 0.000938271 8.448776011 10.05937838 0 Irf7 ENSMUSG00000025498.7 524.1640164 0.962913355 0.229691073 4.192210612 2.76E-05 0.003839866 8.358422249 9.775274706 0 Irgm1 ENSMUSG00000046879.5 1797.683476 0.991877777 0.220079665 4.506903345 6.58E-06 0.001208974 10.00981119 11.37122343 0 Irgm2 ENSMUSG00000069874.5 1437.095038 1.122783883 0.221586379 5.067025717 4.04E-07 0.000118161 9.563860849 11.11865941 0 Isg15 ENSMUSG00000035692.6 903.7732692 1.215863783 0.230055903 5.285079691 1.26E-07 4.16E-05 8.458378639 10.56476178 0 Isoc1 ENSMUSG00000024601.8 1138.16647 0.717270413 0.173447016 4.135386293 3.54E-05 0.004651934 9.844481159 10.62945769 0 Itgb3 ENSMUSG00000020689.3 2379.90968 -0.617726946 0.1714958 -3.601994599 0.000315785 0.023564681 11.5948317 10.88701269 0 Kcnt2 ENSMUSG00000052726.9 88.10514438 1.31150977 0.230073802 5.700387251 1.20E-08 5.52E-06 6.760506698 7.992483556 0 Kctd14 ENSMUSG00000051727.8 88.82710972 -1.149097173 0.228782768 -5.022656128 5.10E-07 0.000145338 7.948664487 6.9245143 0 Ldhb ENSMUSG00000030246.5 1197.244605 -0.778222001 0.189442872 -4.107950825 3.99E-05 0.005079169 10.73194289 9.830795026 0 Lgals3bp ENSMUSG00000033880.5 6153.879946 0.687187552 0.194321901 3.536336091 0.000405718 0.028679421 12.09992198 12.97294532 0 Lgr4 ENSMUSG00000050199.7 4528.279781 -1.034820367 0.17903148 -5.780102844 7.47E-09 3.98E-06 12.66755472 11.42900721 0 Lrrc17 ENSMUSG00000039883.4 3232.096947 -0.969161246 0.174880397 -5.54185183 2.99E-08 1.21E-05 12.16335887 11.03321976 0 Matn4 ENSMUSG00000016995.10 1306.075986 -1.313456152 0.210295222 -6.245772689 4.22E-10 3.49E-07 11.04339018 9.387492106 0 Mid2 ENSMUSG00000000266.5 314.1152591 1.476611136 0.219094959 6.739594307 1.59E-11 1.88E-08 7.678649588 9.301072365 0 Mlkl ENSMUSG00000012519.8 559.2866379 0.721594822 0.196828355 3.666112138 0.000246266 0.019404544 8.939550365 9.72195125 0 Mnda ENSMUSG00000026536.8 718.6231767 0.721469632 0.196583223 3.670046815 0.000242506 0.019285061 9.228230391 10.04203838 0 Mndal ENSMUSG00000090272.1 624.0356124 0.927979439 0.221798285 4.183889161 2.87E-05 0.003917399 8.777523714 9.949940527 0 Msln ENSMUSG00000063011.6 205.7745877 2.042203263 0.228167152 8.950470053 3.54E-19 9.76E-16 6.804626056 8.912485864 0 Mum1l1 ENSMUSG00000042515.6 675.8913765 0.62459445 0.18196993 3.43240474 0.000598254 0.039113516 9.251923291 9.915305009 0 Naip2 ENSMUSG00000078945.3 410.8626677 0.69635528 0.19705543 3.533804067 0.000409625 0.028832344 8.615383852 9.336784135 0 Nbl1 ENSMUSG00000041120.6 795.3113983 -1.003308181 0.219671302 -4.567315668 4.94E-06 0.000938271 10.31031173 8.98521153 0 Nhsl1 ENSMUSG00000039835.9 68.68859592 0.803482557 0.228975571 3.509031793 0.000449741 0.030996534 6.857290553 7.694030123 0 Nov ENSMUSG00000037362.8 135.6977437 0.888715471 0.220446318 4.031437136 5.54E-05 0.006412451 7.423627866 8.234684055 0 Npy1r ENSMUSG00000036437.5 523.2427676 1.073856903 0.192662443 5.573773942 2.49E-08 1.06E-05 8.630204618 9.763023657 0 Oas1a ENSMUSG00000052776.9 125.4017777 1.067439213 0.21652405 4.929887527 8.23E-07 0.000223105 6.568195041 8.266642085 0 Oas1b ENSMUSG00000029605.8 164.0228813 0.899523892 0.229943962 3.911926557 9.16E-05 0.009407078 7.354313854 8.445962626 0 Oas1g ENSMUSG00000066861.7 85.5312805 0.939647645 0.211520722 4.442343211 8.90E-06 0.001565843 6.476224945 7.89723614 0 Olfm2 ENSMUSG00000032172.6 103.9405172 -1.247317576 0.22981827 -5.427408259 5.72E-08 2.10E-05 8.117009647 6.905920997 0 Parp14 ENSMUSG00000034422.8 1494.193381 0.871102673 0.229898901 3.789068459 0.000151213 0.013742957 9.494723117 11.09835904 0 Pcdhb9 ENSMUSG00000051242.1 288.4433475 -0.7849521 0.20010254 -3.922749308 8.75E-05 0.009107353 8.96271443 8.192412553 0 Pcx ENSMUSG00000024892.8 1475.788156 -0.63758911 0.181223154 -3.51825414 0.000434396 0.030317917 10.95070966 10.22142989 0 Pdgfra ENSMUSG00000029231.9 10313.91456 -0.637519583 0.185406061 -3.438504548 0.000584937 0.038547562 13.67541278 12.89905494 0 Pdzd2 ENSMUSG00000022197.8 203.7953628 -0.78131975 0.229540067 -3.403849103 0.000664434 0.042108853 8.686267362 7.545992286 0 Peg3 ENSMUSG00000002265.8 1809.318698 -0.938766571 0.199003408 -4.717339165 2.39E-06 0.000526994 11.37906686 10.18632798 0 Peli2 ENSMUSG00000021846.7 1544.595161 -0.683578514 0.17500864 -3.905970102 9.38E-05 0.009582356 11.0300917 10.25797534 0 Phf17 ENSMUSG00000025764.8 1928.637609 0.633985027 0.179623492 3.529521784 0.000416311 0.029178845 10.57644742 11.31797631 0 Pi16 ENSMUSG00000024011.9 215.159971 -0.902338999 0.20630505 -4.373809543 1.22E-05 0.001999609 8.684906226 7.838454061 0 Plekha6 ENSMUSG00000041757.8 608.9398066 -0.935804408 0.229224619 -4.082477746 4.46E-05 0.005541618 9.949361542 8.573045655 0 Plekhg3 ENSMUSG00000052609.7 1237.649195 -0.650210467 0.1767221 -3.679282143 0.000233891 0.018820037 10.71598714 9.992460654 0 Plin4 ENSMUSG00000002831.7 3568.725284 -1.103578155 0.173208282 -6.371393689 1.87E-10 1.63E-07 12.3508062 11.0622547 0 Ppap2b ENSMUSG00000028517.8 11062.67099 -0.705709172 0.174285752 -4.04915012 5.14E-05 0.006117072 13.80358006 12.96480754 0 Ppp1r12b ENSMUSG00000073557.4 1402.06385 0.633969242 0.171206774 3.70294486 0.000213111 0.017450854 10.1733106 10.87462789 0 Ppp1r3b ENSMUSG00000046794.8 208.0053341 -0.818523535 0.21425324 -3.820355458 0.000133259 0.012595686 8.635323207 7.82624243 0 Prkd1 ENSMUSG00000002688.7 56.44004144 1.816518737 0.228180084 7.960899579 1.71E-15 4.04E-12 6.059021277 7.730164595 0 Prl2c2 ENSMUSG00000079092.2 449.9731722 -1.091769979 0.229583597 -4.755435472 1.98E-06 0.000470608 9.714803764 8.031230018 0 Prl2c3 ENSMUSG00000056457.5 378.8859919 -1.084082394 0.229691084 -4.719740851 2.36E-06 0.000526994 9.501903642 7.879459276 0 Prl2c5 ENSMUSG00000055360.7 84.78662615 -0.884919832 0.22825279 -3.876928879 0.000105783 0.01051636 7.908313696 6.873580456 0 Psmb10 ENSMUSG00000031897.8 1001.695932 0.666389117 0.182491668 3.651613938 0.000260597 0.020237287 9.70381427 10.44320593 0 Psmb8 ENSMUSG00000024338.8 109.2108368 0.79562295 0.228832531 3.476878694 0.000507287 0.034109914 7.255580033 8.023596247 0 Ptgfr ENSMUSG00000028036.5 1854.848483 -0.71668325 0.192976791 -3.713831318 0.000204145 0.016968647 11.31199308 10.42863005 0 Ptn ENSMUSG00000029838.7 87307.59739 -0.582270952 0.16465191 -3.536375326 0.000405658 0.028679421 16.7171212 16.03178965 0 Ptprj ENSMUSG00000025314.9 302.2835842 0.858132879 0.202017332 4.247818099 2.16E-05 0.003245984 8.188204932 9.040960615 0 Ptprq ENSMUSG00000035916.5 60.93794345 1.329857985 0.22965041 5.790792996 7.01E-09 3.86E-06 6.526733532 7.706200998 0 Ptx3 ENSMUSG00000027832.4 1501.22054 -0.986598025 0.194255082 -5.07887883 3.80E-07 0.000114184 11.1154133 9.945328103 0 Rab12 ENSMUSG00000023460.6 435.0515098 -0.763712042 0.192470715 -3.967938932 7.25E-05 0.007994475 9.430338319 8.641454894 0 Rarres2 ENSMUSG00000009281.4 115.7627458 -1.122184735 0.230009631 -4.878859761 1.07E-06 0.000275772 8.173658647 7.036160162 0 Rasl12 ENSMUSG00000041696.7 121.1268263 -0.950647594 0.225517833 -4.215398761 2.49E-05 0.003579157 8.155782146 7.271066809 0 Rgs16 ENSMUSG00000026475.7 652.2624913 -1.035492011 0.185263945 -5.589279714 2.28E-08 9.93E-06 10.02371195 8.923771163 0 Robo1 ENSMUSG00000022883.9 74.3101431 1.320802964 0.224565198 5.881601306 4.06E-09 2.49E-06 6.358761202 7.90765365 0 Robo2 ENSMUSG00000052516.11 96.17303093 1.617582824 0.230120325 7.029291398 2.08E-12 3.12E-09 6.572471613 8.12802987 0 Ror1 ENSMUSG00000035305.5 435.2279104 -0.96423203 0.200830575 -4.801221277 1.58E-06 0.000389333 9.503520887 8.488026229 0 Rsad2 ENSMUSG00000020641.8 116.5456493 0.95267751 0.204073288 4.668310689 3.04E-06 0.00062791 6.288158529 8.123273197 0 Rtp4 ENSMUSG00000033355.5 451.6048583 1.09117853 0.229986708 4.744528677 2.09E-06 0.000473554 7.94140568 9.646995804 0 S100b ENSMUSG00000033208.7 69.67574297 -1.075905107 0.22999804 -4.677888157 2.90E-06 0.000606876 7.744291202 6.802636103 0 Scn7a ENSMUSG00000034810.7 253.175491 0.904957829 0.20493777 4.4157689 1.01E-05 0.001734248 7.984498251 8.861251701 0 Sdpr ENSMUSG00000045954.6 695.5291206 0.778814755 0.188755876 4.12604244 3.69E-05 0.004795394 9.168465774 10.01722339 0 Sema6a ENSMUSG00000019647.9 211.1419923 1.968635434 0.213435879 9.223545005 2.87E-20 9.51E-17 7.144704644 8.913734822 0 Serpina3n ENSMUSG00000021091.8 196.8201581 -0.987693508 0.212971102 -4.637687928 3.52E-06 0.000707411 8.623965656 7.687932257 0 Serpine2 ENSMUSG00000026249.4 5546.608163 -1.246297056 0.168165727 -7.411123998 1.25E-13 2.59E-10 13.01627858 11.56737137 0 Sfrp2 ENSMUSG00000027996.7 1361.818825 -1.107042094 0.18434457 -6.005287246 1.91E-09 1.29E-06 11.02419988 9.753123247 0 Sh2d3c ENSMUSG00000059013.6 80.75845234 -1.074917408 0.229346088 -4.686879186 2.77E-06 0.000588271 7.857074581 6.900311796 0 Slc2a13 ENSMUSG00000036298.9 337.5273245 -0.691490202 0.202472975 -3.415222211 0.0006373 0.041178042 9.113248497 8.396287083 0 Slc43a1 ENSMUSG00000027075.10 82.56104892 -1.106316605 0.230020341 -4.809646837 1.51E-06 0.000378932 7.894971469 6.85795575 0 Slc5a3 ENSMUSG00000089774.1 7561.318589 -0.741092029 0.17788528 -4.166123418 3.10E-05 0.00416649 13.27586639 12.39233129 0 Slc9a9 ENSMUSG00000031129.9 387.7347321 0.843226682 0.198833136 4.240876038 2.23E-05 0.003317873 8.454736481 9.323123916 0 Slco3a1 ENSMUSG00000025790.8 465.2718115 0.892814125 0.190376088 4.689738783 2.74E-06 0.000587644 8.633767524 9.556644194 0 Slfn2 ENSMUSG00000072620.3 81.666877 0.734098607 0.21697741 3.383295087 0.000716216 0.044874751 6.815118862 7.780723393 0 Slfn8 ENSMUSG00000035208.9 197.2322794 0.865049755 0.227562256 3.801376239 0.000143895 0.013371689 7.39671922 8.625807509 0 Slit3 ENSMUSG00000056427.4 2700.509396 -0.742118141 0.19974312 -3.715362723 0.000202912 0.016968647 11.82978338 10.90695542 0 Snn ENSMUSG00000037972.6 2178.608115 -0.658066346 0.169450011 -3.883542666 0.000102945 0.010383054 11.48734475 10.74330945 0 Sorcs1 ENSMUSG00000043531.8 1893.944197 0.671613237 0.197173371 3.406206594 0.000658723 0.041907458 10.48333975 11.31986579 0 Sp100 ENSMUSG00000026222.9 389.153328 0.90459698 0.229467379 3.942159381 8.08E-05 0.008562224 8.132595913 9.40752986 0 Sp110 ENSMUSG00000070034.7 108.9013148 0.792557897 0.227941032 3.477030391 0.000507 0.034109914 7.269534637 8.017918046 0 Sparcl1 ENSMUSG00000029309.3 7788.866822 -0.751324624 0.210180148 -3.574669791 0.00035067 0.02555258 13.36294505 12.29326418 Page 47 of 79 Diabetes
0 Stat1 ENSMUSG00000026104.7 4558.340816 0.745073476 0.217954471 3.418482184 0.000629714 0.040847474 11.52374229 12.57549732 0 Stbd1 ENSMUSG00000047963.5 159.8457237 1.021334528 0.227376301 4.491824894 7.06E-06 0.00126962 7.380013799 8.461411758 0 Steap1 ENSMUSG00000015652.3 259.696202 0.766554623 0.203162618 3.773108608 0.000161226 0.014415353 8.096642502 8.841606346 0 Syt13 ENSMUSG00000027220.2 291.1718516 1.055006429 0.215634969 4.892557238 9.95E-07 0.000261332 7.944104584 9.09442782 0 Tcf7l2 ENSMUSG00000024985.11 908.8465458 -0.959012655 0.218498283 -4.38910843 1.14E-05 0.001908247 10.47996354 9.182239492 0 Tgfb2 ENSMUSG00000039239.8 672.6288127 -0.789864301 0.204834655 -3.856106769 0.000115207 0.011209659 10.00194573 9.063375809 0 Tgm2 ENSMUSG00000037820.9 34.9913297 0.755123939 0.211995974 3.561973017 0.000368078 0.026703429 6.392664408 7.274296437 0 Tgtp1 ENSMUSG00000078922.3 757.1413611 0.973103333 0.23000472 4.230797226 2.33E-05 0.003408683 8.641142486 10.18726374 0 Tgtp2 ENSMUSG00000078921.3 852.445808 0.958488298 0.229981042 4.167683947 3.08E-05 0.00416649 8.788996133 10.32739069 0 Timp4 ENSMUSG00000030317.6 23.2647729 -0.945881749 0.204908742 -4.616112233 3.91E-06 0.000769935 7.095439162 6.050626362 0 Tmcc2 ENSMUSG00000042066.9 653.9266109 -0.6719743 0.183804829 -3.655912107 0.000256269 0.020077932 9.894408649 9.177780434 0 Tmem26 ENSMUSG00000060044.6 16.91367337 -0.724343046 0.194372623 -3.726569272 0.000194104 0.016464974 6.91580074 6.090363918 0 Tmem44 ENSMUSG00000022537.9 392.1320304 -0.648644541 0.192691842 -3.366227316 0.000762039 0.046684757 9.261415871 8.604013095 0 Tor3a ENSMUSG00000060519.5 2250.942456 0.681612443 0.18495689 3.685250337 0.000228478 0.018525754 10.74610456 11.54663032 0 Trib3 ENSMUSG00000032715.8 2033.956195 0.746252273 0.179276487 4.162577508 3.15E-05 0.004197616 10.56666827 11.43740262 0 Tril ENSMUSG00000043496.5 1740.021683 -0.691109238 0.186467439 -3.706326643 0.000210287 0.017305265 11.19806966 10.39099643 0 Trim30a ENSMUSG00000030921.9 2007.300965 0.797071555 0.214585583 3.71446928 0.000203631 0.016968647 10.39601336 11.44197081 0 Trim30d ENSMUSG00000057596.7 818.1355315 0.902882467 0.209217261 4.315525712 1.59E-05 0.002508301 9.20139815 10.28136075 0 Tspan11 ENSMUSG00000030351.4 1258.623798 -1.176806471 0.176499215 -6.667488412 2.60E-11 2.69E-08 10.93050998 9.62810803 0 Tspan7 ENSMUSG00000058254.6 300.7079594 1.132321836 0.209302624 5.409974394 6.30E-08 2.27E-05 7.975049374 9.129080463 0 Txnip ENSMUSG00000038393.7 5192.728778 -0.793015555 0.204556173 -3.876761784 0.000105856 0.01051636 12.80951366 11.70855943 0 Vstm2a ENSMUSG00000048834.8 334.5121669 -1.210026208 0.227162425 -5.326700515 1.00E-07 3.52E-05 9.320843591 7.80292783 0 Xaf1 ENSMUSG00000040483.9 643.1476537 1.004949942 0.229117941 4.386168699 1.15E-05 0.001908247 8.563366416 10.0394049 0 Zfp238 ENSMUSG00000063659.6 368.8406172 0.707662473 0.204327497 3.463373665 0.000533447 0.035579626 8.472213499 9.22215138 2 1190005I06Rik ENSMUSG00000043687.8 152.7490215 -1.16747577 0.226331299 -5.158260373 2.49E-07 1.74E-05 8.787732458 8.029670808 2 1300001I01Rik ENSMUSG00000020741.10 5506.546724 -0.742540675 0.162151073 -4.579313982 4.67E-06 0.000237336 12.8220963 12.02666607 2 1520401A03Rik ENSMUSG00000043747.4 49.68856936 -0.934346532 0.249389524 -3.746534813 0.000179294 0.00568741 8.064833646 7.519938085 2 2010002M12Rik ENSMUSG00000067297.4 41.41832975 1.449504729 0.247470253 5.857288741 4.70E-09 4.74E-07 7.23086758 8.058083833 2 2210020M01Rik ENSMUSG00000048442.9 77.74597626 -1.039547988 0.248369584 -4.185488303 2.85E-05 0.00112822 8.310135856 7.668554618 2 2410006H16Rik ENSMUSG00000086841.1 2960.688514 0.722239179 0.155847172 4.634278367 3.58E-06 0.000186397 11.21346493 11.9702239 2 2410066E13Rik ENSMUSG00000038065.6 131.3681222 -0.793670272 0.234545766 -3.383861009 0.000714742 0.018781432 8.604474241 8.065212457 2 3110039M20Rik ENSMUSG00000089922.1 23.62486596 0.993434715 0.23178722 4.285977089 1.82E-05 0.000762415 7.146042831 7.792410947 2 5430417L22Rik ENSMUSG00000074918.4 1537.899208 -0.49238476 0.150975944 -3.261345801 0.001108847 0.026834777 11.01034013 10.53536191 2 6330406I15Rik ENSMUSG00000029659.9 953.9797169 1.678950416 0.180219106 9.31616215 1.21E-20 5.82E-18 9.234898576 10.77368411 2 9130208D14Rik ENSMUSG00000086513.1 44.82989377 1.252857333 0.245270512 5.108063421 3.25E-07 2.24E-05 7.284302447 8.064553535 2 A430107O13Rik ENSMUSG00000062980.9 2519.898919 -0.514252982 0.161614383 -3.181975351 0.001462743 0.034203692 11.67174254 11.1272859 2 A430110N23Rik ENSMUSG00000035279.7 485.4977888 0.859661997 0.197446095 4.353907306 1.34E-05 0.000591542 9.045042281 9.778990069 2 A530016L24Rik ENSMUSG00000043122.6 65.50169676 -1.013457984 0.249356099 -4.064299964 4.82E-05 0.001792448 8.212272484 7.571841336 2 A730085A09Rik ENSMUSG00000085843.1 27.80738886 1.111284812 0.237191411 4.685181511 2.80E-06 0.000152018 7.164989847 7.860600803 2 Abca8b ENSMUSG00000020620.8 157.305628 1.236447458 0.231422979 5.342803301 9.15E-08 7.04E-06 7.994443707 8.829162407 2 Abca9 ENSMUSG00000041797.7 149.8191178 1.121681761 0.223215757 5.025101165 5.03E-07 3.30E-05 8.045138224 8.762835469 2 Abhd15 ENSMUSG00000000686.11 289.2514585 -0.735000508 0.202592062 -3.627982759 0.000285644 0.008486195 9.221647912 8.670830822 2 Acadm ENSMUSG00000062908.6 3979.572473 -0.494255281 0.149461404 -3.306909124 0.000943315 0.02382973 12.27704347 11.75724117 2 Acat1 ENSMUSG00000032047.5 3635.903578 -0.435607146 0.142308323 -3.061009626 0.00220592 0.047597656 12.1269476 11.6780154 2 Acat2 ENSMUSG00000023832.7 3453.602617 -0.860616676 0.14766535 -5.828155883 5.60E-09 5.48E-07 12.22357528 11.33946705 2 Acat3 ENSMUSG00000062480.5 1146.192963 -0.946164667 0.156042576 -6.063503253 1.33E-09 1.50E-07 10.80202117 9.92471094 2 Aco1 ENSMUSG00000028405.8 3233.98718 -0.48925775 0.154751745 -3.161565321 0.001569236 0.036006509 11.98637221 11.48499225 2 Acsf2 ENSMUSG00000076435.3 1322.255441 -0.498966598 0.156962838 -3.178883634 0.001478434 0.034368742 10.82058428 10.34667922 2 Acsl1 ENSMUSG00000018796.6 9387.728603 -1.574970008 0.186648279 -8.438170528 3.22E-17 1.07E-14 13.82209843 12.04306539 2 Acvr1b ENSMUSG00000000532.8 1220.898012 -0.489910363 0.154153687 -3.178064525 0.001482618 0.034399662 10.71904099 10.257574 2 Adam15 ENSMUSG00000028041.8 4290.412394 -0.546637067 0.168967235 -3.235166069 0.00121572 0.028851155 12.39199191 11.81513812 2 Adam8 ENSMUSG00000025473.10 562.103131 -0.600615933 0.175408559 -3.424097063 0.000616846 0.016564339 9.851969847 9.343247949 2 Adamts14 ENSMUSG00000059901.6 368.7832786 0.846978565 0.194295315 4.359233072 1.31E-05 0.000580555 8.819495745 9.491455394 2 Adamts2 ENSMUSG00000036545.8 6094.461638 0.439089929 0.139641541 3.144407642 0.001664234 0.037804947 12.37822392 12.84214764 2 Adamts5 ENSMUSG00000022894.5 1684.238592 0.527658562 0.147564943 3.575771799 0.000349196 0.010128597 10.62876016 11.14135004 2 Adamtsl1 ENSMUSG00000066113.8 53.40685992 0.950835524 0.249395971 3.812553661 0.000137538 0.004525126 7.537926564 8.09949778 2 Adamtsl2 ENSMUSG00000036040.8 73.09636584 0.859570666 0.246496933 3.487145484 0.000488206 0.013496854 7.724380902 8.248994975 2 Adar ENSMUSG00000027951.10 1560.372883 0.683886419 0.150071205 4.557079563 5.19E-06 0.00025974 10.44379078 11.10275313 2 Add3 ENSMUSG00000025026.8 7048.488889 -1.116998986 0.158828436 -7.032739327 2.03E-12 3.43E-10 13.30674065 12.09297471 2 Adh1 ENSMUSG00000074207.4 113.2706851 -1.164778291 0.248711657 -4.683247681 2.82E-06 0.000152938 8.562765594 7.74923015 2 Adipoq ENSMUSG00000022878.5 159.6902431 -0.902562776 0.240531362 -3.752370447 0.00017517 0.00556769 8.787692158 8.092248856 2 Adipor2 ENSMUSG00000030168.7 8945.930937 -0.982364266 0.177424891 -5.536789448 3.08E-08 2.58E-06 13.58479726 12.49571662 2 Aebp1 ENSMUSG00000020473.7 1712.257723 0.886238533 0.151147628 5.863396909 4.53E-09 4.63E-07 10.43057123 11.29677571 2 Agpat2 ENSMUSG00000026922.7 1226.377841 -0.825710309 0.206961455 -3.989681596 6.62E-05 0.002410903 10.82203418 10.00234256 2 Agpat9 ENSMUSG00000029314.8 1015.04157 -1.41395613 0.212454372 -6.655340227 2.83E-11 4.17E-09 10.77686284 9.358453135 2 Agtr2 ENSMUSG00000068122.3 423.6451893 1.145137825 0.220687921 5.188946533 2.11E-07 1.51E-05 8.694656177 9.740950619 2 Ahcyl2 ENSMUSG00000029772.9 2066.321022 -0.607852807 0.158639633 -3.831657923 0.000127283 0.004240269 11.43924533 10.82760196 2 AI646023 ENSMUSG00000046807.8 155.4418756 -0.981451932 0.232304165 -4.224857234 2.39E-05 0.000966321 8.762617238 8.093644603 2 Aim1 ENSMUSG00000019866.8 3847.728271 -0.481821912 0.154805352 -3.112437051 0.001855496 0.041151692 12.22166211 11.71878843 2 Ak2 ENSMUSG00000028792.8 2801.574513 -0.594918224 0.155866318 -3.816849146 0.000135167 0.004474835 11.83710684 11.23012635 2 Akr1b3 ENSMUSG00000001642.11 5930.883913 0.702557905 0.147247496 4.771272343 1.83E-06 0.000104861 12.16460106 12.91730095 2 Akr1b8 ENSMUSG00000029762.6 2388.393414 0.482268227 0.142446606 3.385607 0.00071021 0.018694837 11.09875407 11.58038128 2 Aldh1a7 ENSMUSG00000024747.3 375.5919989 -1.301244187 0.217805361 -5.974344166 2.31E-09 2.49E-07 9.654842336 8.532436901 2 Aldh1l2 ENSMUSG00000020256.8 744.4157844 1.152788618 0.177399693 6.498255994 8.13E-11 1.11E-08 9.318200473 10.34593532 2 Aldh3a2 ENSMUSG00000010025.11 2086.70607 0.515940174 0.14489504 3.560785609 0.000369747 0.010666394 10.90519076 11.41574988 2 Aldh4a1 ENSMUSG00000028737.9 2785.797978 -0.899394947 0.147454711 -6.09946568 1.06E-09 1.21E-07 11.94606084 11.03444175 2 Aldh6a1 ENSMUSG00000021238.9 2101.323933 -0.637541516 0.173103723 -3.683002911 0.000230503 0.00708595 11.46512582 10.82131137 2 Aldh9a1 ENSMUSG00000026687.9 1840.908873 -0.514023162 0.157254036 -3.26874385 0.00108026 0.026262699 11.25005231 10.74074051 2 Ampd3 ENSMUSG00000005686.9 668.6683895 0.650493887 0.195456045 3.328082718 0.000874459 0.022423325 9.462016948 10.06809884 2 Angpt4 ENSMUSG00000027460.6 96.06588389 1.456834598 0.244646699 5.954850837 2.60E-09 2.78E-07 7.624180524 8.513186623 2 Angptl4 ENSMUSG00000002289.9 6876.698119 -0.736986055 0.155988485 -4.724618333 2.31E-06 0.000128365 13.13698747 12.3358243 2 Anpep ENSMUSG00000039062.8 1105.223484 -0.641350395 0.171635222 -3.736706185 0.000186447 0.005890824 10.65097092 10.04571053 2 Antxr1 ENSMUSG00000033420.9 9341.305996 -0.572276055 0.134519961 -4.254209208 2.10E-05 0.000856585 13.49735716 12.89238044 2 Antxr2 ENSMUSG00000029338.8 2927.220143 0.515387979 0.144893414 3.55701453 0.000375093 0.010801063 11.34108449 11.86749901 2 Anxa8 ENSMUSG00000021950.9 3290.917421 -1.741227747 0.202222979 -8.610434666 7.28E-18 2.63E-15 12.44500566 10.41273066 2 Apcdd1 ENSMUSG00000071847.5 778.7271585 0.747247586 0.165720748 4.509076832 6.51E-06 0.000312294 9.605638939 10.27174405 Diabetes Page 48 of 79
2 Apln ENSMUSG00000037010.7 850.3786088 1.075404356 0.17454988 6.161014581 7.23E-10 8.46E-08 9.504491979 10.47611185 2 Apobr ENSMUSG00000042759.6 157.873023 0.88201982 0.22396709 3.938167076 8.21E-05 0.002924972 8.166877499 8.749732609 2 Apod ENSMUSG00000022548.8 2251.310267 1.181596569 0.16890442 6.995652153 2.64E-12 4.38E-10 10.53894172 11.75618984 2 Apol9a ENSMUSG00000068246.4 47.22850191 1.390255635 0.245867134 5.654499707 1.56E-08 1.40E-06 7.243557589 8.105372097 2 Apol9b ENSMUSG00000057346.4 45.87065226 1.362957901 0.243783467 5.590854541 2.26E-08 1.92E-06 7.207687751 8.087025357 2 Arhgap12 ENSMUSG00000041225.8 764.9873933 0.624052145 0.166223811 3.754288512 0.000173835 0.005536283 9.653447738 10.20748277 2 Arhgap20 ENSMUSG00000053199.7 1293.802513 0.638784598 0.192935598 3.310869559 0.000930066 0.023583381 10.17526465 10.87026438 2 Arhgap24 ENSMUSG00000057315.7 1058.021185 0.869618434 0.160001682 5.435058079 5.48E-08 4.47E-06 9.873952424 10.68014168 2 Arhgap44 ENSMUSG00000033389.9 406.4932724 -1.039034284 0.191684067 -5.420556336 5.94E-08 4.83E-06 9.641965333 8.811800793 2 Arhgef2 ENSMUSG00000028059.7 2138.635422 0.83578351 0.173461266 4.818271698 1.45E-06 8.51E-05 10.71425021 11.56312829 2 Arhgef3 ENSMUSG00000021895.8 829.5113885 0.625245932 0.170637557 3.664175367 0.000248137 0.007555123 9.737212491 10.30020015 2 Arl4d ENSMUSG00000034936.2 126.2927493 -0.916244865 0.237326257 -3.860697411 0.000113064 0.003838867 8.596460401 7.993855869 2 Armcx2 ENSMUSG00000033436.7 3777.438169 0.440140875 0.138787417 3.171331254 0.00151742 0.034968735 11.72900223 12.18059572 2 Arrdc4 ENSMUSG00000042659.8 172.2652171 -0.829094988 0.240309092 -3.450119095 0.000560339 0.015176361 8.838766875 8.160322762 2 Arxes1 ENSMUSG00000048355.2 245.6468006 -1.036346319 0.220685435 -4.696034063 2.65E-06 0.000145155 9.153793607 8.382032325 2 Arxes2 ENSMUSG00000048040.7 482.3475143 -1.069138971 0.194555208 -5.495298634 3.90E-08 3.23E-06 9.825779804 8.940605538 2 Atp2b4 ENSMUSG00000026463.10 820.1246811 -0.760499524 0.178095282 -4.270183431 1.95E-05 0.000805739 10.33842623 9.638965812 2 Atp8b2 ENSMUSG00000060671.6 4352.728756 -0.446208824 0.137466573 -3.245944202 0.001170618 0.028073672 12.37767251 11.91704032 2 Awat2 ENSMUSG00000031220.8 26.06705794 -1.019589387 0.236632263 -4.308750517 1.64E-05 0.000695317 7.826904225 7.194691828 2 B2m ENSMUSG00000060802.8 8593.61236 0.961782432 0.156208263 6.157052216 7.41E-10 8.61E-08 12.48870664 13.52919545 2 Baiap2l1 ENSMUSG00000038859.7 229.9318776 -1.355384141 0.225233071 -6.017695951 1.77E-09 1.93E-07 9.173056154 8.173410489 2 BC006779 ENSMUSG00000027580.10 1268.095497 1.180497918 0.169974264 6.945156824 3.78E-12 6.14E-10 9.868893756 11.00718071 2 Bcar3 ENSMUSG00000028121.4 1194.862062 -0.786117722 0.181127186 -4.340142076 1.42E-05 0.00062292 10.80350107 10.03279818 2 Bcat1 ENSMUSG00000030268.10 624.740014 0.810570807 0.187867652 4.314584217 1.60E-05 0.000679347 9.326943652 10.03553784 2 Bche ENSMUSG00000027792.5 46.27107555 1.906407963 0.24732274 7.708179037 1.28E-14 2.90E-12 6.937894684 8.153668674 2 Bckdha ENSMUSG00000060376.6 1245.037033 -0.498599146 0.153462517 -3.24899628 0.00115813 0.027900244 10.74640174 10.27691218 2 Bcl11b ENSMUSG00000048251.9 233.3961944 -0.778063811 0.205805085 -3.780585934 0.00015646 0.005074265 9.043291644 8.487480454 2 Bcl2l13 ENSMUSG00000009112.2 2652.303056 -0.600172329 0.151529942 -3.960750726 7.47E-05 0.002685674 11.76851162 11.15704481 2 Bid ENSMUSG00000004446.6 1649.395319 -0.738462827 0.164335324 -4.493634177 7.00E-06 0.00033085 11.19823172 10.46095889 2 Birc3 ENSMUSG00000032000.10 590.753589 0.873096538 0.171661878 5.086141132 3.65E-07 2.50E-05 9.257628847 9.994199458 2 Bnc1 ENSMUSG00000025105.7 66.45756732 1.218556841 0.248056609 4.912414342 9.00E-07 5.60E-05 7.548108641 8.260187369 2 Boc ENSMUSG00000022687.5 3752.035629 -0.570903568 0.143508323 -3.978191333 6.94E-05 0.002524626 12.22823525 11.63605949 2 Bpgm ENSMUSG00000038871.5 595.9387956 0.780836281 0.171500825 4.55295934 5.29E-06 0.000263226 9.314024035 9.975404152 2 Brp44l ENSMUSG00000023861.10 989.3264087 -0.573811893 0.16684813 -3.439126906 0.000583594 0.015777834 10.4909531 9.962931725 2 Bst2 ENSMUSG00000046718.7 589.0229096 1.79148428 0.198432411 9.028183817 1.75E-19 7.51E-17 8.695805914 10.21119956 2 C130026I21Rik ENSMUSG00000052477.9 110.3196854 1.026345825 0.235312534 4.361628372 1.29E-05 0.000575842 7.896174909 8.525959695 2 C1qtnf6 ENSMUSG00000022440.8 2947.797144 0.608586494 0.142297934 4.276847014 1.90E-05 0.000784036 11.29702846 11.9133627 2 C1ra ENSMUSG00000055172.8 1719.828335 0.796314194 0.16156331 4.928805892 8.27E-07 5.19E-05 10.48248485 11.26970602 2 C1rb ENSMUSG00000092005.1 1562.272739 0.692759961 0.160447169 4.317682674 1.58E-05 0.000678603 10.4312378 11.10725559 2 C1s ENSMUSG00000038521.10 1090.873214 0.842212815 0.174052679 4.838838556 1.31E-06 7.79E-05 9.907934852 10.70892573 2 C920025E04Rik ENSMUSG00000073405.5 660.0988383 0.93684255 0.196568636 4.765981852 1.88E-06 0.000106882 9.29695578 10.13409804 2 Cacna1g ENSMUSG00000020866.10 4742.114912 -0.808229888 0.191964595 -4.21030704 2.55E-05 0.001028101 12.66257104 11.69681028 2 Cad ENSMUSG00000013629.10 3369.075459 -0.45523459 0.143933341 -3.162815407 0.001562514 0.035906211 12.03016948 11.5652382 2 Car5b ENSMUSG00000031373.4 4736.314289 -0.752811912 0.168498977 -4.467753614 7.90E-06 0.000366973 12.61193607 11.81124627 2 Casp12 ENSMUSG00000025887.3 541.969998 0.886397477 0.180756424 4.903822823 9.40E-07 5.82E-05 9.156693693 9.906687707 2 Casp4 ENSMUSG00000033538.7 355.6362634 0.863800505 0.198249202 4.357144937 1.32E-05 0.000584486 8.776098391 9.462636313 2 Ccdc85a ENSMUSG00000032878.10 40.89834843 1.379338604 0.244383905 5.644146671 1.66E-08 1.48E-06 7.172359566 8.057855364 2 Ccl11 ENSMUSG00000020676.2 30.5402368 0.806482599 0.23821085 3.38558298 0.000710272 0.018694837 7.330410327 7.841431578 2 Ccl2 ENSMUSG00000035385.5 402.4145418 2.624441862 0.227867391 11.51740867 1.08E-30 1.91E-27 7.853808598 9.896688247 2 Ccl5 ENSMUSG00000035042.2 105.8187557 2.162349694 0.241618366 8.949442574 3.57E-19 1.42E-16 7.441838172 8.658604725 2 Ccl7 ENSMUSG00000035373.2 539.270772 2.572437742 0.224449172 11.46111488 2.07E-30 3.29E-27 8.055266322 10.21632787 2 Ccl9 ENSMUSG00000019122.7 89.47019419 1.026798814 0.246909512 4.158603709 3.20E-05 0.001249717 7.735875838 8.399531053 2 Ccnd1 ENSMUSG00000070348.4 3620.860325 -0.561304785 0.143293782 -3.917160804 8.96E-05 0.00314698 12.17541464 11.59494374 2 Cd14 ENSMUSG00000051439.6 150.7464217 0.825892427 0.224905787 3.67217063 0.000240499 0.00736482 8.155968218 8.705374762 2 Cd36 ENSMUSG00000002944.8 441.9323314 -1.532482043 0.233819629 -6.554120592 5.60E-11 8.03E-09 9.858606964 8.434499866 2 Cd74 ENSMUSG00000024610.8 32.31385735 0.981747613 0.242040235 4.056133947 4.99E-05 0.001843329 7.297247506 7.895481724 2 Cdc42ep1 ENSMUSG00000049521.1 1491.155157 0.586980993 0.155400557 3.777212938 0.000158593 0.005113497 10.43913059 11.01038046 2 Cdca7 ENSMUSG00000055612.9 485.5041511 -0.585522797 0.187977493 -3.114855868 0.001840348 0.040872669 9.693602591 9.195182628 2 Cdo1 ENSMUSG00000033022.7 2801.994133 -0.724340215 0.145805261 -4.96786062 6.77E-07 4.28E-05 11.88959103 11.15658802 2 Cdr2l ENSMUSG00000050910.5 2052.090886 0.543704408 0.146057534 3.722535859 0.000197232 0.006182521 10.86688835 11.40524245 2 Cdsn ENSMUSG00000039518.7 201.3182041 1.672475183 0.235936388 7.08866994 1.35E-12 2.34E-10 7.911232871 9.100147392 2 Cebpa ENSMUSG00000034957.9 2887.470102 -0.703812049 0.183339627 -3.83884303 0.000123615 0.004135403 11.90826197 11.17222708 2 Ces1f ENSMUSG00000031725.8 569.8515941 -1.606966364 0.203763234 -7.886439247 3.11E-15 7.62E-13 10.16428408 8.738311342 2 Cfd ENSMUSG00000061780.5 94.25379301 -1.070838914 0.249404797 -4.293577861 1.76E-05 0.000741316 8.419448409 7.679651944 2 Cfh ENSMUSG00000026365.9 5091.921361 3.049459497 0.2037128 14.96940545 1.16E-50 1.85E-46 9.724707761 13.22978475 2 Cfhr2 ENSMUSG00000033898.10 475.8320107 2.875610721 0.217692624 13.20950002 7.73E-40 4.11E-36 7.90419645 10.11366147 2 Cfhr3 ENSMUSG00000090623.1 41.54414628 1.526454319 0.24660164 6.189960121 6.02E-10 7.43E-08 7.172337258 8.068809986 2 Chac1 ENSMUSG00000027313.3 229.9258497 1.052710744 0.245193825 4.293381963 1.76E-05 0.000741316 8.210940679 9.075544406 2 Chn2 ENSMUSG00000004633.9 70.851339 -1.46711916 0.248137063 -5.912535371 3.37E-09 3.51E-07 8.328496522 7.482615718 2 Chrdl1 ENSMUSG00000031283.8 798.864727 -0.800976263 0.16441107 -4.871790359 1.11E-06 6.77E-05 10.31774031 9.606287214 2 Chst8 ENSMUSG00000060402.6 177.8224829 -0.674385348 0.214959008 -3.137274183 0.001705266 0.038408277 8.789764231 8.335087852 2 Cib2 ENSMUSG00000037493.6 473.1827669 -1.523163416 0.202113316 -7.53618539 4.84E-14 1.06E-11 9.914340779 8.662708212 2 Cidec ENSMUSG00000030278.5 1034.151757 -1.486051913 0.20489511 -7.252744649 4.08E-13 7.74E-11 10.82759011 9.355296923 2 Clec14a ENSMUSG00000045930.2 830.6317548 -0.594734309 0.170542881 -3.487300703 0.000487922 0.013496854 10.29533836 9.750785155 2 Clmn ENSMUSG00000021097.7 146.8903772 -1.279077179 0.227677484 -5.617934442 1.93E-08 1.70E-06 8.778893571 7.961431924 2 Cmpk2 ENSMUSG00000020638.7 52.4671826 1.432519888 0.248933797 5.754621934 8.68E-09 8.09E-07 7.327883065 8.163611213 2 Cnn2 ENSMUSG00000004665.4 1960.668341 0.688559199 0.152335743 4.520010767 6.18E-06 0.000300209 10.71985418 11.40040977 2 Cnnm2 ENSMUSG00000064105.5 1065.373371 -0.848272761 0.180189117 -4.707680327 2.51E-06 0.000138233 10.67873584 9.871677336 2 Col11a1 ENSMUSG00000027966.10 1742.27661 0.689445051 0.179103654 3.849419229 0.000118398 0.00398599 10.54648332 11.2413053 2 Col15a1 ENSMUSG00000028339.11 1301.154702 -0.934922787 0.174564815 -5.355734404 8.52E-08 6.67E-06 10.9693552 10.04070282 2 Col1a1 ENSMUSG00000001506.9 72198.94594 0.838618266 0.142810611 5.872240591 4.30E-09 4.42E-07 15.61182543 16.5271355 2 Col27a1 ENSMUSG00000045672.7 1774.485699 0.590289664 0.187982601 3.140129259 0.001688733 0.038089781 10.60224291 11.24217551 2 Col3a1 ENSMUSG00000026043.11 144436.6989 0.473004221 0.147890301 3.198345099 0.001382188 0.032415252 16.84838389 17.37937298 2 Col5a2 ENSMUSG00000026042.9 29268.77791 0.427317888 0.134611976 3.174441829 0.00150125 0.03474695 14.60009121 15.06011225 2 Cox4nb ENSMUSG00000031819.6 1467.54075 -0.557982944 0.167612551 -3.329004553 0.00087157 0.022385286 10.97480541 10.4291867 2 Cp ENSMUSG00000003617.10 2260.265656 0.863389091 0.188990069 4.568436292 4.91E-06 0.000246835 10.71361389 11.66851866 Page 49 of 79 Diabetes
2 Cpt2 ENSMUSG00000028607.9 2438.973692 -0.729236858 0.153475537 -4.751485947 2.02E-06 0.00011443 11.70419688 10.96937738 2 Crat ENSMUSG00000026853.8 2307.259248 -0.524991242 0.168997629 -3.106500628 0.001893159 0.041815529 11.54339119 11.0145995 2 Creb3l1 ENSMUSG00000027230.9 1511.904077 0.631302908 0.195188158 3.234329971 0.001219285 0.028892699 10.3631214 11.05768821 2 Csf1 ENSMUSG00000014599.4 3344.0387 1.217743323 0.162597533 7.489309938 6.92E-14 1.45E-11 11.01648323 12.30863091 2 Csgalnact1 ENSMUSG00000036356.8 552.3891918 0.662016448 0.178144778 3.716170935 0.000202265 0.006303061 9.292537903 9.855309388 2 Csmd1 ENSMUSG00000060924.7 18.84033481 0.953519646 0.219209013 4.349819534 1.36E-05 0.000599348 6.937894684 7.721617024 2 Csrp2 ENSMUSG00000020186.5 806.3068372 -0.66683344 0.16237542 -4.106738806 4.01E-05 0.001536071 10.28366878 9.689842783 2 Ctla2a ENSMUSG00000044258.9 3533.716569 0.893280801 0.199439171 4.478963668 7.50E-06 0.000350264 11.24823294 12.2612216 2 Ctla2b ENSMUSG00000074874.3 716.2689537 0.865199264 0.203529706 4.25097289 2.13E-05 0.000864624 9.399591205 10.21060747 2 Ctsb ENSMUSG00000021939.6 19217.8932 0.778234848 0.133419258 5.833002349 5.44E-09 5.35E-07 13.7724902 14.60521622 2 Ctsl ENSMUSG00000021477.7 6606.769081 0.672154473 0.142837274 4.705735808 2.53E-06 0.000138897 12.34220777 13.05047023 2 Cxcl1 ENSMUSG00000029380.10 193.4778179 0.866406168 0.236115577 3.669415548 0.000243106 0.007430353 8.260644383 8.901249889 2 Cxcl10 ENSMUSG00000034855.7 59.31140255 1.581563299 0.249146571 6.347923205 2.18E-10 2.87E-08 7.295287569 8.25003828 2 Cxcl13 ENSMUSG00000023078.4 1723.679168 1.122905423 0.199545583 5.627312837 1.83E-08 1.62E-06 10.16182708 11.41008129 2 Cxcl5 ENSMUSG00000029371.5 300.1651516 0.705386823 0.209534023 3.36645483 0.000761411 0.019811603 8.69466758 9.255560191 2 Cxcr7 ENSMUSG00000044337.5 730.4909602 0.625505723 0.189292038 3.304448139 0.000951636 0.023935816 9.58019507 10.15318302 2 Cyb5r1 ENSMUSG00000026456.11 1204.594697 0.766009695 0.175404854 4.367095206 1.26E-05 0.000563199 10.06779843 10.80043683 2 Cycs ENSMUSG00000063694.5 3539.280389 -0.73681498 0.163918426 -4.495010108 6.96E-06 0.000329696 12.20772024 11.43801796 2 Cyp51 ENSMUSG00000001467.4 2140.001588 -0.745334644 0.164408447 -4.533432793 5.80E-06 0.000286103 11.53409969 10.78396409 2 D14Ertd668e ENSMUSG00000068245.7 57.78472181 1.242397583 0.249415154 4.981243371 6.32E-07 4.01E-05 7.458319125 8.186492564 2 D1Ertd622e ENSMUSG00000044768.10 429.0069078 -0.591825314 0.183477237 -3.2256062 0.001257062 0.029699486 9.562223728 9.086925759 2 Daam2 ENSMUSG00000040260.7 1239.01143 -1.225975505 0.158135157 -7.752706804 9.00E-15 2.11E-12 10.98464609 9.837193398 2 Dapk1 ENSMUSG00000021559.7 198.8768553 -0.789136305 0.213990542 -3.687715814 0.000226276 0.006969481 8.909851862 8.36305671 2 Dbi ENSMUSG00000026385.9 2196.314937 -0.746964993 0.147816915 -5.053312032 4.34E-07 2.91E-05 11.57206149 10.83000544 2 Ddah1 ENSMUSG00000028194.9 1256.239635 -0.670907498 0.163910059 -4.093144145 4.26E-05 0.001613492 10.82121933 10.18376017 2 Ddah2 ENSMUSG00000007039.6 517.0348425 0.55485665 0.177241446 3.130513002 0.001745013 0.039137441 9.281072469 9.747963001 2 Ddit3 ENSMUSG00000025408.9 806.9097652 1.043021659 0.207381652 5.02947898 4.92E-07 3.24E-05 9.405841636 10.39437544 2 Ddx4 ENSMUSG00000021758.7 225.3976208 -1.044887767 0.218779058 -4.775995376 1.79E-06 0.000102799 9.091223419 8.317653678 2 Ddx58 ENSMUSG00000040296.8 1382.933325 1.237479384 0.162454574 7.617387136 2.59E-14 5.73E-12 9.946303569 11.12722422 2 Ddx60 ENSMUSG00000037921.8 67.55006026 1.554559602 0.249242974 6.23712506 4.46E-10 5.68E-08 7.349200609 8.309553049 2 Dgat1 ENSMUSG00000022555.5 1559.763055 -0.663095742 0.159271924 -4.163293339 3.14E-05 0.001230345 11.09443469 10.44781918 2 Dgat2 ENSMUSG00000030747.4 827.4345726 -1.415489927 0.206777313 -6.845479851 7.62E-12 1.21E-09 10.52378981 9.191655134 2 Dhx58 ENSMUSG00000017830.8 145.6213648 1.432807929 0.232495777 6.162726685 7.15E-10 8.43E-08 7.880409397 8.799957091 2 Dio2 ENSMUSG00000007682.5 216.5028685 2.172539575 0.226660819 9.584980701 9.25E-22 5.45E-19 7.792781027 9.233022193 2 Disp2 ENSMUSG00000040035.7 1402.590509 -0.816110424 0.175637026 -4.646573922 3.37E-06 0.000177955 11.02360609 10.20018078 2 Dlc1 ENSMUSG00000031523.8 4322.813933 -0.443064495 0.140869409 -3.145214402 0.001659652 0.037754701 12.36653561 11.90783623 2 Dld ENSMUSG00000020664.8 3479.921112 -0.585636389 0.154952168 -3.779465612 0.000157165 0.005086789 12.12894577 11.51961336 2 Dlst ENSMUSG00000004789.8 3717.820084 -0.456233462 0.146043968 -3.123945953 0.001784432 0.039853156 12.16402981 11.69522624 2 Dmd ENSMUSG00000045103.10 123.1157026 2.354870134 0.241383367 9.755726603 1.74E-22 1.21E-19 7.419150334 8.784232173 2 Dmkn ENSMUSG00000060962.6 18.54098218 -0.754701182 0.223388833 -3.378419473 0.000729038 0.019062723 7.681948491 7.179499784 2 Dnaja4 ENSMUSG00000032285.9 217.8121678 -0.952189791 0.227509367 -4.185277312 2.85E-05 0.00112822 9.022478619 8.326977798 2 Dpt ENSMUSG00000026574.4 2317.844182 1.925806805 0.188032412 10.24188745 1.29E-24 1.02E-21 9.932124236 12.00236342 2 Dtna ENSMUSG00000024302.8 73.671862 0.762953988 0.249378445 3.059422354 0.002217643 0.047785848 7.709875765 8.251845872 2 Dtx3l ENSMUSG00000049502.10 525.2520465 1.170121372 0.188496472 6.207656632 5.38E-10 6.74E-08 8.967964341 9.951211746 2 Dtx4 ENSMUSG00000039982.7 358.6817928 1.075394766 0.189615922 5.671437062 1.42E-08 1.29E-06 8.699499555 9.521731379 2 Dusp18 ENSMUSG00000047205.6 681.3577055 -0.63515444 0.196304879 -3.235550954 0.001214082 0.028851155 10.0717123 9.498392186 2 E2f8 ENSMUSG00000046179.10 122.5557878 -0.750851464 0.239698266 -3.132486003 0.001733327 0.038985166 8.543791344 8.031303705 2 Ebf2 ENSMUSG00000022053.6 324.299822 -0.863674264 0.205279106 -4.207316955 2.58E-05 0.001036546 9.37123676 8.692240201 2 Ebp ENSMUSG00000031168.8 725.6473887 0.556803507 0.166694435 3.340264516 0.000836986 0.021601571 9.632827337 10.12172563 2 Ece1 ENSMUSG00000057530.7 2627.292504 -0.62916284 0.145065198 -4.337103918 1.44E-05 0.000628138 11.76731651 11.13208307 2 Echdc2 ENSMUSG00000028601.11 1102.752824 -0.495529549 0.156984815 -3.156544475 0.001596505 0.036526942 10.59626381 10.13350908 2 Eda2r ENSMUSG00000034457.4 1165.666797 0.722655514 0.155995433 4.632542778 3.61E-06 0.000187354 10.072839 10.74842265 2 Efna3 ENSMUSG00000028039.7 39.91391178 -0.852240633 0.242406478 -3.515750248 0.000438513 0.012425063 7.97809736 7.377213213 2 Egfl7 ENSMUSG00000026921.11 44.37269309 -0.836422529 0.249184885 -3.356634288 0.000788974 0.020495304 7.995549539 7.513675639 2 Egr1 ENSMUSG00000038418.6 2196.221233 0.61904896 0.197961683 3.127115068 0.001765308 0.039536945 10.84033094 11.51744624 2 Eif2ak2 ENSMUSG00000024079.4 1790.764854 0.542150367 0.148842097 3.642453173 0.000270052 0.00812913 10.69588961 11.22609132 2 Elac2 ENSMUSG00000020549.8 1579.573677 -0.609990004 0.156520226 -3.897196029 9.73E-05 0.00336141 11.08936136 10.49782756 2 Elk3 ENSMUSG00000008398.7 693.2884577 0.533258867 0.174438441 3.057003178 0.002235619 0.04791386 9.588332862 10.06422036 2 Elovl1 ENSMUSG00000006390.9 2648.460456 -0.659799493 0.164310937 -4.015554331 5.93E-05 0.002171017 11.78482851 11.10996242 2 Emx2 ENSMUSG00000043969.3 161.6887192 0.696780936 0.220305267 3.162797442 0.00156261 0.035906211 8.259689295 8.722101193 2 Emx2os ENSMUSG00000087095.2 74.03857929 0.769667182 0.247762012 3.106477765 0.001893305 0.041815529 7.753794734 8.237311765 2 Endod1 ENSMUSG00000037419.7 724.2825502 -1.052521247 0.203480995 -5.172577662 2.31E-07 1.63E-05 10.27893674 9.299384081 2 Enpp2 ENSMUSG00000022425.9 6950.451776 1.356518488 0.145411674 9.32881417 1.07E-20 5.33E-18 11.91889776 13.35591571 2 Entpd5 ENSMUSG00000021236.10 1004.926089 -0.971501717 0.16476787 -5.896184235 3.72E-09 3.85E-07 10.6470152 9.755590879 2 Epas1 ENSMUSG00000024140.9 721.2830018 -1.216025729 0.172659996 -7.042892139 1.88E-12 3.22E-10 10.32091286 9.262471708 2 Epha2 ENSMUSG00000006445.3 197.5996348 0.689829321 0.210907917 3.270760675 0.001072586 0.026155996 8.4029986 8.878716022 2 Epn2 ENSMUSG00000001036.10 2528.084267 0.649690367 0.143270118 4.534723473 5.77E-06 0.000285242 11.07169303 11.72345973 2 Erap1 ENSMUSG00000021583.5 901.6968224 0.501496933 0.160402781 3.126485281 0.001769094 0.039566076 9.900080294 10.35562193 2 Ereg ENSMUSG00000029377.4 314.8343277 1.331649328 0.19670023 6.769942908 1.29E-11 1.97E-09 8.471158325 9.451812765 2 Ergic1 ENSMUSG00000001576.8 6827.463712 -0.453626656 0.137201812 -3.306273063 0.000945459 0.02382973 13.00600317 12.52879903 2 Ero1l ENSMUSG00000021831.7 3932.885103 0.891529939 0.178879535 4.983968345 6.23E-07 3.98E-05 11.45139174 12.40189722 2 Ezr ENSMUSG00000052397.8 1970.01634 -0.512067916 0.15604604 -3.281518175 0.001032499 0.02529463 11.33977534 10.8256671 2 F11r ENSMUSG00000038235.4 49.66560599 0.876086263 0.249412908 3.512593914 0.000443755 0.01248473 7.545837212 8.052702969 2 F3 ENSMUSG00000028128.8 3328.383816 -0.64019819 0.157763828 -4.057952953 4.95E-05 0.00183756 12.09197555 11.42182897 2 Fabp4 ENSMUSG00000062515.2 1127.080575 -1.910446739 0.184741304 -10.3411998 4.59E-25 4.10E-22 11.01837896 9.236478453 2 Fabp5 ENSMUSG00000027533.9 2690.735308 -1.50732684 0.180575707 -8.347340108 6.98E-17 2.14E-14 12.07333752 10.49710663 2 Fam107a ENSMUSG00000021750.9 2435.150794 -1.318652972 0.189773427 -6.948564891 3.69E-12 6.06E-10 11.90398201 10.47638046 2 Fam115c ENSMUSG00000029851.4 917.5476409 -0.81648133 0.168450165 -4.847020065 1.25E-06 7.56E-05 10.4871033 9.741354736 2 Fam122b ENSMUSG00000036022.8 544.1141709 -0.641553875 0.174930034 -3.667488417 0.000244945 0.007472219 9.830064884 9.292485261 2 Fam124a ENSMUSG00000035184.8 209.211633 -0.787970661 0.209455761 -3.761990871 0.000168566 0.005391231 8.9510315 8.404815008 2 Fam13c ENSMUSG00000043259.8 206.8574126 0.647195078 0.210073185 3.080807669 0.002064399 0.045032189 8.453419275 8.903651379 2 Fam160a1 ENSMUSG00000051000.10 565.3749293 -0.687002771 0.175910064 -3.905420504 9.41E-05 0.003270389 9.886711354 9.305851269 2 Fam195a ENSMUSG00000025732.5 234.7210007 -0.857186114 0.224305707 -3.821508275 0.000132638 0.004400264 9.063095551 8.42835914 2 Fam198b ENSMUSG00000027955.10 300.4033461 0.83757827 0.218415376 3.834795361 0.000125669 0.004195286 8.6040754 9.308405098 2 Fam20a ENSMUSG00000020614.7 155.5433505 0.984751389 0.222812456 4.419642453 9.89E-06 0.000449804 8.117768686 8.7639237 2 Fam20c ENSMUSG00000025854.9 1327.379558 -0.485549543 0.157542838 -3.082015964 0.002056038 0.044911318 10.82246571 10.35600426 Diabetes Page 50 of 79
2 Fam38b ENSMUSG00000041482.8 86.26066371 -0.800373408 0.243754991 -3.28351598 0.001025208 0.025193545 8.330770447 7.830380929 2 Fam73b ENSMUSG00000026858.11 1316.771807 -0.812621737 0.17494932 -4.644897936 3.40E-06 0.000178226 10.9277691 10.14346308 2 Fam83a ENSMUSG00000051225.3 636.0501306 -1.207690418 0.195833324 -6.166930089 6.96E-10 8.27E-08 10.17024294 9.106533779 2 Fblim1 ENSMUSG00000006219.6 195.8012028 0.963501401 0.213481271 4.513283034 6.38E-06 0.000308017 8.28133225 8.941483038 2 Fbln5 ENSMUSG00000021186.8 3321.014966 -1.153627586 0.14574881 -7.915176722 2.47E-15 6.24E-13 12.26752165 11.09101458 2 Fbxo2 ENSMUSG00000041556.8 964.0237001 -0.884804873 0.186673173 -4.739860909 2.14E-06 0.000120339 10.56358339 9.734217817 2 Fgf7 ENSMUSG00000027208.8 1346.593296 0.893881044 0.159334042 5.610107131 2.02E-08 1.75E-06 10.13239822 10.99207725 2 Fgfr2 ENSMUSG00000030849.10 7695.949248 -1.019161081 0.155852592 -6.539262938 6.18E-11 8.79E-09 13.39595108 12.29287763 2 Fgfr3 ENSMUSG00000054252.9 585.8333158 -1.967987988 0.181834736 -10.82294851 2.68E-27 3.28E-24 10.23791475 8.64593211 2 Fgfrl1 ENSMUSG00000008090.8 3957.693413 -0.55071422 0.151632498 -3.631901002 0.000281341 0.008405394 12.29401344 11.71243731 2 Fhl2 ENSMUSG00000008136.8 336.4827952 0.671436753 0.194587235 3.450569376 0.000559405 0.015176361 8.823994605 9.350818654 2 Fhod3 ENSMUSG00000034295.8 25.97543034 0.881477914 0.237944158 3.704557908 0.00021176 0.00657322 7.266060787 7.803418929 2 Fibin ENSMUSG00000074971.3 91.25933038 0.751541127 0.242967085 3.09318082 0.001980234 0.043554216 7.878084562 8.353049901 2 Figf ENSMUSG00000031380.9 1294.586115 0.730023424 0.178094641 4.09907575 4.15E-05 0.00157645 10.16006217 10.88798765 2 Fitm2 ENSMUSG00000048486.6 4057.154803 -0.732857554 0.187319143 -3.912347367 9.14E-05 0.003192022 12.38931464 11.58312905 2 Fkbp14 ENSMUSG00000038074.9 1476.321225 -0.597763112 0.151657046 -3.941545255 8.10E-05 0.00289054 10.99988683 10.42539109 2 Fkbp4 ENSMUSG00000030357.4 3800.498599 -0.520045374 0.15019796 -3.46239971 0.000535381 0.014648477 12.22013004 11.68381689 2 Fkbp5 ENSMUSG00000024222.9 30777.16907 -0.431124731 0.136897669 -3.149248155 0.001636911 0.037344091 15.13379111 14.66811 2 Flrt2 ENSMUSG00000047414.5 920.1202997 0.641921037 0.178997359 3.586203964 0.000335527 0.009785577 9.822202955 10.44031891 2 Fmo1 ENSMUSG00000040181.8 175.9151969 -0.90272419 0.234228392 -3.854034012 0.000116187 0.003919849 8.835318057 8.195631899 2 Fn1 ENSMUSG00000026193.8 172883.004 0.566358718 0.13934486 4.064439248 4.81E-05 0.001792448 17.0558268 17.67692201 2 Foxred2 ENSMUSG00000016552.7 964.0507179 -0.658956703 0.170506054 -3.864711475 0.000111221 0.003784352 10.4946281 9.880162877 2 Frk ENSMUSG00000019779.8 771.3880701 1.187261069 0.167443028 7.090537507 1.34E-12 2.34E-10 9.352768235 10.39138985 2 G0s2 ENSMUSG00000009633.2 79.93298678 -1.040162243 0.248434265 -4.186871101 2.83E-05 0.001125932 8.319649316 7.586851228 2 Gab2 ENSMUSG00000004508.5 311.471035 0.678629727 0.213472103 3.179008962 0.001477795 0.034368742 8.73445422 9.27646386 2 Gabre ENSMUSG00000031340.8 623.4006152 0.653159989 0.192597643 3.391318697 0.000695572 0.018368629 9.390527152 9.995442894 2 Gadd45g ENSMUSG00000021453.2 1422.85227 -0.534958701 0.15735424 -3.399709488 0.000674575 0.017963093 10.92684529 10.41421624 2 Gale ENSMUSG00000028671.10 470.6667991 -0.663431043 0.189601645 -3.499078527 0.000466869 0.013036188 9.679190594 9.133299799 2 Galm ENSMUSG00000035473.4 635.5510595 -0.690662953 0.195214285 -3.537973428 0.000403211 0.011527336 10.0233282 9.390716501 2 Gbp1 ENSMUSG00000028269.4 17.28997316 0.675622357 0.220954986 3.057737547 0.002230148 0.047861021 7.194997742 7.649878122 2 Gbp10 ENSMUSG00000054588.7 227.3952042 1.911744868 0.232794466 8.212157711 2.17E-16 6.18E-14 7.879007468 9.246616636 2 Gbp11 ENSMUSG00000092021.1 21.93961257 0.758809329 0.231821672 3.273245866 0.0010632 0.025966854 7.249271223 7.731358874 2 Gbp2 ENSMUSG00000028270.6 214.6908444 2.055318609 0.229496635 8.955767937 3.37E-19 1.38E-16 7.819437216 9.210427904 2 Gbp3 ENSMUSG00000028268.8 123.0156902 1.965946246 0.242895627 8.093790195 5.78E-16 1.59E-13 7.538802279 8.745056831 2 Gbp4 ENSMUSG00000079363.2 69.12749087 1.810550099 0.248745171 7.278734654 3.37E-13 6.54E-11 7.34002668 8.353658808 2 Gbp6 ENSMUSG00000079362.2 310.8513678 2.013601884 0.2235909 9.005741685 2.14E-19 8.98E-17 8.046701974 9.559134206 2 Gbp7 ENSMUSG00000040253.9 323.4231273 1.301504356 0.231978713 5.61044736 2.02E-08 1.75E-06 8.355425294 9.521850172 2 Gbp8 ENSMUSG00000034438.9 38.46121324 1.203233974 0.246684036 4.877632114 1.07E-06 6.60E-05 7.294991598 7.997459295 2 Gbp9 ENSMUSG00000029298.8 152.4604451 2.380142051 0.23723395 10.03288968 1.09E-23 8.29E-21 7.514150693 8.955081837 2 Gda ENSMUSG00000058624.6 3808.317736 -0.545138732 0.150860428 -3.613530318 0.000302056 0.008907296 12.23988145 11.66421421 2 Gdf10 ENSMUSG00000021943.5 28.71707164 -1.154005124 0.239762882 -4.813109997 1.49E-06 8.70E-05 7.877990503 7.179597281 2 Gja1 ENSMUSG00000050953.8 2563.673513 1.182735807 0.15874253 7.450654875 9.29E-14 1.90E-11 10.72371972 11.92387696 2 Glns-ps1 ENSMUSG00000082100.1 2361.882004 -0.693193964 0.151398836 -4.578595056 4.68E-06 0.000237394 11.65287919 10.94795161 2 Glud1 ENSMUSG00000021794.9 14651.06615 -0.763264941 0.156743881 -4.869503898 1.12E-06 6.83E-05 14.21142273 13.37611288 2 Glul ENSMUSG00000026473.9 20307.65937 -0.686526516 0.137509758 -4.992565802 5.96E-07 3.84E-05 14.6497514 13.90786017 2 Gm10053 ENSMUSG00000058927.4 1618.652114 -0.736198689 0.164703453 -4.469843685 7.83E-06 0.000364468 11.16674706 10.44512033 2 Gm10108 ENSMUSG00000062038.3 1626.87623 -0.716281434 0.167445223 -4.277706 1.89E-05 0.000783051 11.16502232 10.46106746 2 Gm10121 ENSMUSG00000062813.6 808.409598 -0.770840514 0.178171506 -4.32639614 1.52E-05 0.000654087 10.3207213 9.621737425 2 Gm10499 ENSMUSG00000073403.4 507.6292477 1.012945998 0.209144531 4.843282276 1.28E-06 7.67E-05 8.980852858 9.865901917 2 Gm10638 ENSMUSG00000074178.2 254.3289695 -0.617178182 0.200768928 -3.07407221 0.002111583 0.045998427 9.072404412 8.624111084 2 Gm11127 ENSMUSG00000079492.2 917.1474447 1.03788043 0.202583872 5.123213513 3.00E-07 2.08E-05 9.5507125 10.54834018 2 Gm11625 ENSMUSG00000080839.1 381.7744232 -0.766998781 0.188345704 -4.072292402 4.66E-05 0.001744247 9.4983075 8.898181873 2 Gm12138 ENSMUSG00000082087.3 1872.684058 0.746219097 0.167888501 4.44473025 8.80E-06 0.000403846 10.5993865 11.3733957 2 Gm12141 ENSMUSG00000058809.6 7724.867434 -0.597289048 0.154899673 -3.855973579 0.00011527 0.003897152 13.23953989 12.59532883 2 Gm12250 ENSMUSG00000082292.2 31.86258166 0.989389805 0.239335005 4.133911812 3.57E-05 0.001378745 7.245185838 7.905255159 2 Gm13252 ENSMUSG00000084105.1 192.3317757 -0.711494749 0.216848562 -3.281067415 0.00103415 0.025296172 8.860385497 8.370727316 2 Gm13772 ENSMUSG00000080977.1 952.3777813 -0.763690782 0.1665644 -4.584958016 4.54E-06 0.000231754 10.5138028 9.814697771 2 Gm13998 ENSMUSG00000081056.1 59.79452779 -1.095550658 0.248963816 -4.4004413 1.08E-05 0.000488717 8.179771505 7.548284533 2 Gm14328 ENSMUSG00000082401.1 205.9872052 -1.448289689 0.222524314 -6.508455926 7.59E-11 1.05E-08 9.083420207 8.088132897 2 Gm14446 ENSMUSG00000079339.6 19.44803586 0.846885719 0.223873079 3.782883248 0.000155022 0.005037903 7.128720483 7.715051526 2 Gm15433 ENSMUSG00000073632.3 40.58685578 1.062747798 0.247863712 4.287629638 1.81E-05 0.000758763 7.381936122 7.998617873 2 Gm16026 ENSMUSG00000079455.2 29.69284932 0.776216918 0.241187011 3.218319744 0.00128944 0.03041932 7.350514576 7.834672041 2 Gm16332 ENSMUSG00000089991.1 573.0038282 2.85101238 0.219496264 12.98888795 1.41E-38 4.51E-35 7.986809367 10.33736005 2 Gm16340 ENSMUSG00000090222.1 315.4901772 1.015118048 0.20375875 4.981960519 6.29E-07 4.01E-05 8.606992903 9.379354523 2 Gm16703 ENSMUSG00000087237.1 20.74253105 -0.926415877 0.224082698 -4.134258844 3.56E-05 0.001378745 7.750890522 7.049749259 2 Gm17782 ENSMUSG00000092366.1 371.6264634 0.969057954 0.220400999 4.396794742 1.10E-05 0.000495589 8.713544448 9.528547571 2 Gm2619 ENSMUSG00000091199.1 27.01186119 0.833191312 0.239580227 3.477713175 0.000505711 0.013932419 7.305321654 7.807562882 2 Gm2635 ENSMUSG00000089763.1 25.80344921 0.870936718 0.237984773 3.65963211 0.000252578 0.00767566 7.270377832 7.799444255 2 Gm2666 ENSMUSG00000090189.3 28.72886891 0.759706962 0.240831305 3.154519143 0.001607628 0.036728656 7.352780436 7.817702977 2 Gm4070 ENSMUSG00000078606.1 229.5767962 2.508772443 0.240834779 10.41698567 2.07E-25 2.06E-22 7.555017971 9.30556282 2 Gm4788 ENSMUSG00000070594.4 539.6454102 3.030679325 0.211253629 14.34616457 1.13E-46 8.96E-43 7.940297227 10.26924211 2 Gm4951 ENSMUSG00000073555.1 96.89102005 1.517161167 0.248060035 6.116104774 9.59E-10 1.10E-07 7.557022641 8.526771471 2 Gm5077 ENSMUSG00000079343.2 490.2039895 0.74271064 0.186947657 3.972826676 7.10E-05 0.00257045 9.132547733 9.74971054 2 Gm5514 ENSMUSG00000045104.8 222.9220669 -0.818930222 0.206677406 -3.962359696 7.42E-05 0.002673669 9.013621104 8.438147664 2 Gm5834 ENSMUSG00000085867.1 80.42558003 1.791288663 0.248872224 7.197623869 6.13E-13 1.13E-10 7.373144761 8.445500667 2 Gm6166 ENSMUSG00000074280.4 1399.220574 -1.480916812 0.184502154 -8.026555678 1.00E-15 2.66E-13 11.20107471 9.751568522 2 Gm6644 ENSMUSG00000073674.3 2429.241955 0.692557652 0.148851239 4.652683146 3.28E-06 0.00017567 10.98702381 11.6893206 2 Gm6736 ENSMUSG00000071414.3 3538.992506 0.725004641 0.156015678 4.646998637 3.37E-06 0.000177955 11.44336499 12.21531737 2 Gm7582 ENSMUSG00000061852.8 35.90682719 1.042699032 0.2449275 4.257174195 2.07E-05 0.00084748 7.320863032 7.948637054 2 Gm7592 ENSMUSG00000090186.3 136.6752072 1.698704935 0.231835419 7.327201969 2.35E-13 4.62E-11 7.753916458 8.792216762 2 Gm7609 ENSMUSG00000079457.3 67.02652635 1.414132139 0.2479662 5.702922984 1.18E-08 1.08E-06 7.489738519 8.289513323 2 Gm8810 ENSMUSG00000091373.2 198.5340852 0.992145058 0.231634494 4.283235381 1.84E-05 0.000769849 8.231397069 8.959779767 2 Gm8815 ENSMUSG00000092224.1 419.3499995 0.993178038 0.219266405 4.529549517 5.91E-06 0.000289619 8.801218921 9.657039863 2 Gm8979 ENSMUSG00000091928.1 23.69012619 0.855852558 0.222500722 3.846515863 0.000119809 0.004016515 7.142329364 7.759227697 2 Gm8989 ENSMUSG00000091567.1 23.69012619 0.855852558 0.222500722 3.846515863 0.000119809 0.004016515 7.142329364 7.759227697 2 Gm9574 ENSMUSG00000073980.3 436.1647102 1.024243954 0.216134662 4.738915756 2.15E-06 0.000120476 8.824009221 9.709463275 Page 51 of 79 Diabetes
2 Gpr116 ENSMUSG00000056492.4 21.72294093 -0.656343826 0.206352719 -3.180689008 0.001469253 0.034255313 7.680720883 7.13199995 2 Gpr149 ENSMUSG00000043441.5 777.0307061 1.680061684 0.179932604 9.337172056 9.89E-21 5.25E-18 9.046165011 10.52197491 2 Gpr155 ENSMUSG00000041762.8 2721.748617 -1.211364816 0.144156549 -8.403120258 4.35E-17 1.41E-14 12.01410965 10.79951096 2 Gpr56 ENSMUSG00000031785.8 74.09229959 -0.896130323 0.246796786 -3.631045348 0.000282276 0.008417521 8.260181201 7.718895399 2 Gpr88 ENSMUSG00000068696.5 76.68393036 0.801851172 0.246277327 3.255887098 0.001130387 0.027314539 7.764301024 8.2647901 2 Gramd1b ENSMUSG00000040111.8 565.8172446 0.842393365 0.195248125 4.314476075 1.60E-05 0.000679347 9.195478305 9.943159516 2 Grhl1 ENSMUSG00000020656.9 106.9465773 -1.385463475 0.236594177 -5.855864637 4.75E-09 4.75E-07 8.569464554 7.747040224 2 Gria3 ENSMUSG00000001986.9 79.16753501 1.294453475 0.245379131 5.27532015 1.33E-07 1.00E-05 7.613563527 8.368220553 2 Gsdmd ENSMUSG00000022575.4 66.21717834 1.498431989 0.248248866 6.036007397 1.58E-09 1.73E-07 7.450079059 8.294168751 2 Gvin1 ENSMUSG00000045868.5 224.6754454 2.493807677 0.241174553 10.34026039 4.63E-25 4.10E-22 7.548838589 9.285207427 2 H2-Bl ENSMUSG00000073406.2 404.4219455 0.949264745 0.211299893 4.492499876 7.04E-06 0.000331634 8.820833374 9.605043019 2 H2-D1 ENSMUSG00000073411.4 6928.283098 1.023264981 0.192117642 5.326241629 1.00E-07 7.68E-06 12.07573651 13.23300177 2 H2-K1 ENSMUSG00000061232.8 3273.948464 1.291741711 0.189075903 6.831868535 8.38E-12 1.32E-09 10.87968788 12.28214929 2 H2-K2 ENSMUSG00000067203.6 636.9320114 1.005286491 0.208456114 4.822533002 1.42E-06 8.39E-05 9.196982599 10.10947192 2 H2-Q10 ENSMUSG00000067235.7 704.7546622 0.947784186 0.204021633 4.645508281 3.39E-06 0.000178226 9.336686359 10.21221157 2 H2-Q4 ENSMUSG00000035929.10 710.2512211 1.04578215 0.207381106 5.042803421 4.59E-07 3.04E-05 9.27874558 10.24615522 2 H2-Q6 ENSMUSG00000073409.5 822.5483913 1.022787245 0.199405827 5.129174306 2.91E-07 2.02E-05 9.456861006 10.41520595 2 H2-Q7 ENSMUSG00000060550.8 884.7137764 0.947787932 0.198752564 4.768682792 1.85E-06 0.000105837 9.579392418 10.47917359 2 H2-Q8 ENSMUSG00000055413.9 187.9979258 0.950697567 0.223173053 4.259911996 2.05E-05 0.000839324 8.242179047 8.90482731 2 H2-T10 ENSMUSG00000079491.2 525.8342992 0.925496998 0.196265463 4.715536712 2.41E-06 0.000133759 9.077084234 9.896055955 2 H2-T22 ENSMUSG00000056116.11 1135.898628 1.065641297 0.184000957 5.791498681 6.98E-09 6.73E-07 9.803068965 10.82379444 2 H2-T23 ENSMUSG00000067212.7 1026.421892 1.0262686 0.196796005 5.214885339 1.84E-07 1.33E-05 9.692504415 10.68184392 2 H2-T24 ENSMUSG00000053835.10 187.1756982 0.816863937 0.239706553 3.407766398 0.000654969 0.017470239 8.237218934 8.872878701 2 H2-T3 ENSMUSG00000054128.10 130.9182106 0.814111528 0.230221372 3.536211784 0.000405909 0.011583687 8.075217096 8.59653887 2 H2afj ENSMUSG00000060032.4 2119.456514 -0.585777387 0.158713121 -3.690793694 0.000223555 0.006899024 11.461175 10.87578921 2 Hadha ENSMUSG00000025745.5 4873.790188 -0.467011816 0.148688698 -3.140869638 0.00168447 0.038047517 12.53971326 12.05310415 2 Heg1 ENSMUSG00000075254.4 566.2459458 0.704095175 0.17253642 4.080849566 4.49E-05 0.001697226 9.300794608 9.895225342 2 Herc6 ENSMUSG00000029798.8 311.5564549 1.29056661 0.208314777 6.195271558 5.82E-10 7.24E-08 8.456953911 9.433955527 2 Hmcn1 ENSMUSG00000066842.11 92.89975062 1.626305697 0.249234683 6.525198162 6.79E-11 9.49E-09 7.456563659 8.505995344 2 Hmga1 ENSMUSG00000046711.9 2033.520022 0.80193289 0.165120296 4.856658519 1.19E-06 7.26E-05 10.67967871 11.49095936 2 Hmgcs2 ENSMUSG00000027875.6 833.3032525 -0.638286601 0.208322579 -3.063933846 0.002184472 0.047293571 10.34211573 9.648607838 2 Hr ENSMUSG00000022096.8 180.9695436 -1.867533532 0.233928886 -7.983338712 1.42E-15 3.72E-13 9.061617458 7.777723205 2 Hs6st1 ENSMUSG00000045216.6 3035.359234 -0.466387971 0.152072513 -3.06687883 0.002163065 0.047055533 11.89148729 11.4168565 2 Hs6st2 ENSMUSG00000062184.5 253.7847837 1.459741283 0.202939504 7.192987346 6.34E-13 1.15E-10 8.257566099 9.272616306 2 Hspa12a ENSMUSG00000025092.6 484.8771044 -0.585018236 0.180568765 -3.23986397 0.001195867 0.028507473 9.688529776 9.204090839 2 Hspd1 ENSMUSG00000025980.8 16419.4958 -0.604048738 0.154395841 -3.912338134 9.14E-05 0.003192022 14.31009084 13.6484266 2 Htra3 ENSMUSG00000029096.8 411.0768753 0.732092253 0.191937619 3.814219739 0.000136614 0.004504015 8.966702382 9.570054471 2 I830012O16Rik ENSMUSG00000062488.8 127.3643082 2.690560013 0.243650817 11.04268827 2.38E-28 3.44E-25 7.281221272 8.833219168 2 Id1 ENSMUSG00000042745.9 2496.197962 -0.697988881 0.144758662 -4.821741724 1.42E-06 8.39E-05 11.72585282 11.02372141 2 Idh3a ENSMUSG00000032279.9 2246.735604 -0.735082741 0.175846447 -4.180253591 2.91E-05 0.001150575 11.59153064 10.83835798 2 Ifi202b ENSMUSG00000026535.8 2686.792006 0.858492134 0.149156202 5.755658313 8.63E-09 8.08E-07 11.01242426 11.88360017 2 Ifi203 ENSMUSG00000039997.10 1527.187665 1.170385731 0.175331215 6.675284436 2.47E-11 3.67E-09 10.08221044 11.2330442 2 Ifi27l1 ENSMUSG00000064215.7 2428.378072 1.016583585 0.160245992 6.343893975 2.24E-10 2.92E-08 10.7632806 11.80444646 2 Ifi27l2a ENSMUSG00000079017.3 126.1478757 2.031299564 0.238744851 8.508244479 1.77E-17 5.98E-15 7.560470309 8.773831172 2 Ifi44 ENSMUSG00000028037.7 547.5851486 2.108221364 0.225889741 9.332966386 1.03E-20 5.29E-18 8.316268268 10.16347664 2 Ifi47 ENSMUSG00000078920.2 53.20127173 1.43950482 0.249317445 5.773782979 7.75E-09 7.39E-07 7.343025563 8.176478698 2 Ifih1 ENSMUSG00000026896.7 119.6163962 1.22631898 0.235150772 5.215032772 1.84E-07 1.33E-05 7.859251037 8.61918923 2 Ifit1 ENSMUSG00000034459.8 317.0349931 2.666985788 0.227237818 11.73654023 8.28E-32 1.88E-28 7.728871556 9.664837941 2 Ifit2 ENSMUSG00000045932.6 110.3788537 1.54517745 0.237673734 6.501254564 7.97E-11 1.09E-08 7.696742447 8.615419029 2 Ifit3 ENSMUSG00000074896.3 156.2024513 2.803798921 0.241469701 11.61139021 3.61E-31 7.18E-28 7.324076698 9.001466172 2 Igfbp3 ENSMUSG00000020427.5 2143.148122 0.884400124 0.150869473 5.862021709 4.57E-09 4.64E-07 10.70979559 11.58881339 2 Igfbp4 ENSMUSG00000017493.5 33346.08653 0.542895911 0.134948659 4.022981143 5.75E-05 0.002113372 14.7119042 15.29899876 2 Igsf10 ENSMUSG00000036334.7 273.2450686 1.123475091 0.2148436 5.229269524 1.70E-07 1.24E-05 8.427763345 9.27091388 2 Igsf3 ENSMUSG00000042035.6 1129.410437 -0.57065967 0.164578547 -3.467400093 0.000525519 0.014403383 10.65643666 10.11210101 2 Igtp ENSMUSG00000078853.2 189.9852954 1.948808602 0.221873108 8.783437617 1.59E-18 6.01E-16 7.846702703 9.092601439 2 Iigp1 ENSMUSG00000054072.5 161.1704838 1.517261602 0.232408477 6.528426242 6.65E-11 9.37E-09 7.890564392 8.899709726 2 Il17rc ENSMUSG00000030281.9 2363.048779 -0.551733525 0.176695343 -3.1225131 0.001793141 0.03999157 11.58423539 11.02019818 2 Il1rn ENSMUSG00000026981.9 501.7733189 0.723390153 0.189810396 3.81111978 0.000138339 0.004542073 9.159583244 9.768547726 2 Impa2 ENSMUSG00000024525.6 327.8461786 -0.929124613 0.198916261 -4.670933435 3.00E-06 0.000161849 9.393415555 8.685334367 2 Iqsec1 ENSMUSG00000034312.6 3703.753908 -0.65257386 0.149938056 -4.35228972 1.35E-05 0.000594274 12.24125216 11.56449852 2 Irf1 ENSMUSG00000018899.9 1311.890457 1.023266081 0.152420073 6.713460136 1.90E-11 2.86E-09 10.03452985 10.99662691 2 Irf7 ENSMUSG00000025498.7 130.5547466 1.540515958 0.247208119 6.231656003 4.62E-10 5.83E-08 7.655710698 8.742068213 2 Irf9 ENSMUSG00000002325.8 530.1435835 1.248502624 0.193196322 6.462351928 1.03E-10 1.38E-08 8.926627329 9.976652624 2 Irgm1 ENSMUSG00000046879.5 494.859865 1.241778139 0.195806517 6.341863175 2.27E-10 2.94E-08 8.865714952 9.901145337 2 Irgm2 ENSMUSG00000069874.5 288.6038968 1.942825842 0.211517567 9.185174867 4.11E-20 1.87E-17 8.098058894 9.478099238 2 Isg15 ENSMUSG00000035692.6 222.5558451 1.86372685 0.226581176 8.22542669 1.94E-16 5.63E-14 7.930959499 9.219040297 2 Islr ENSMUSG00000037206.7 349.439262 1.002344629 0.196679842 5.096326182 3.46E-07 2.38E-05 8.696507596 9.482776146 2 Itga6 ENSMUSG00000027111.8 5179.315579 -0.812203557 0.136772855 -5.938338818 2.88E-09 3.06E-07 12.76522369 11.92201793 2 Itga7 ENSMUSG00000025348.7 76.05958669 -0.758805166 0.247705671 -3.06333385 0.002188857 0.047293571 8.241396391 7.775203446 2 Itgb3 ENSMUSG00000020689.3 2273.903727 -0.477482669 0.156329709 -3.054330944 0.002255631 0.048212978 11.51110795 11.0306807 2 Itgbl1 ENSMUSG00000032925.9 248.2739237 0.823455414 0.22158324 3.716235107 0.000202213 0.006303061 8.484871307 9.107220525 2 Itpkb ENSMUSG00000038855.8 3079.020442 -0.457064322 0.149199312 -3.063447928 0.002188023 0.047293571 11.90918569 11.44096866 2 Itpr1 ENSMUSG00000030102.7 2430.570857 -0.535724276 0.17515446 -3.05858199 0.002223872 0.047790742 11.6324673 11.05170013 2 Itsn1 ENSMUSG00000022957.12 4906.123798 -0.636350727 0.149763994 -4.249023486 2.15E-05 0.000869963 12.62009758 11.95430173 2 Ivd ENSMUSG00000027332.5 2494.451185 -0.457484369 0.149296743 -3.064262216 0.002182076 0.047293571 11.62947518 11.16309867 2 Jagn1 ENSMUSG00000051256.9 1324.165491 -0.608915532 0.164001823 -3.712858305 0.000204932 0.006373694 10.86337685 10.2819063 2 Junb ENSMUSG00000052837.4 2283.254623 0.722792064 0.147037204 4.915708721 8.85E-07 5.52E-05 10.89409012 11.61521701 2 Kank1 ENSMUSG00000032702.9 168.7999635 -0.98725677 0.21958025 -4.496109146 6.92E-06 0.000328977 8.825095828 8.173439846 2 Kcnd1 ENSMUSG00000009731.4 371.7804458 0.729362177 0.19614066 3.718566966 0.000200356 0.006268118 8.882818868 9.461490036 2 Kcnj2 ENSMUSG00000041695.2 28.07364618 1.228570487 0.23398597 5.250616034 1.52E-07 1.12E-05 7.009378459 7.880470263 2 Kcnt2 ENSMUSG00000052726.9 77.83380214 1.187975833 0.247684659 4.796323841 1.62E-06 9.39E-05 7.615821624 8.348799815 2 Kdm2b ENSMUSG00000029475.11 1753.491775 -0.496401478 0.150143427 -3.306181892 0.000945767 0.02382973 11.18089939 10.69470677 2 Kif21b ENSMUSG00000041642.11 70.37757868 0.962912443 0.24853529 3.874348968 0.00010691 0.003653298 7.650907273 8.248453609 2 Klf5 ENSMUSG00000005148.7 1039.107803 -0.638706978 0.164968165 -3.871698394 0.00010808 0.003685354 10.57983776 9.97900221 2 Klhl25 ENSMUSG00000055652.7 869.373939 -0.549496497 0.166092909 -3.308368196 0.000938413 0.023757227 10.32978495 9.831075836 2 Krt15 ENSMUSG00000054146.7 678.5037416 -1.055428685 0.22335957 -4.725244966 2.30E-06 0.000128365 10.21756928 9.151108405 Diabetes Page 52 of 79
2 Krt36 ENSMUSG00000020916.8 46.81177401 -0.823095453 0.249158112 -3.303506547 0.000954837 0.023935816 8.017242043 7.532638066 2 Krt9 ENSMUSG00000051617.3 92.08135066 -2.375678401 0.246435961 -9.640144999 5.41E-22 3.31E-19 8.581173235 7.265375239 2 Ksr1 ENSMUSG00000018334.9 5946.229247 0.454702049 0.137275649 3.312328535 0.000925228 0.023535678 12.33705632 12.81394816 2 Lass4 ENSMUSG00000008206.7 2245.330292 -0.588086479 0.145898702 -4.030786229 5.56E-05 0.002049131 11.54170667 10.95475273 2 Lbh ENSMUSG00000024063.6 1903.867085 1.102646191 0.172037578 6.409333372 1.46E-10 1.94E-08 10.37862035 11.51787757 2 Ldhb ENSMUSG00000030246.5 2054.485237 -1.04040104 0.144593638 -7.195344517 6.23E-13 1.14E-10 11.58435811 10.56383601 2 Lef1 ENSMUSG00000027985.8 657.1841666 -0.615265204 0.175303473 -3.509714867 0.000448587 0.012598424 10.03278366 9.490339571 2 Lgals3bp ENSMUSG00000033880.5 2454.761441 1.285790958 0.162861525 7.894995177 2.90E-15 7.22E-13 10.5871953 11.89903841 2 Lgals7 ENSMUSG00000053522.5 55.44839157 -0.875623831 0.249280372 -3.512606404 0.000443734 0.01248473 8.103553733 7.592791195 2 Lgals9 ENSMUSG00000001123.9 1578.992702 1.447570034 0.158734676 9.119431693 7.55E-20 3.34E-17 9.961469517 11.35708351 2 Lgr4 ENSMUSG00000050199.7 7403.049473 -0.727459216 0.135028998 -5.38742955 7.15E-08 5.70E-06 13.2325565 12.46824006 2 Lhfpl2 ENSMUSG00000045312.5 3660.732087 1.023734627 0.169362023 6.044652796 1.50E-09 1.67E-07 11.25734504 12.37454273 2 Lims2 ENSMUSG00000024395.7 177.8056002 -0.890872881 0.218478356 -4.077625347 4.55E-05 0.001716849 8.845985989 8.242429547 2 Lipa ENSMUSG00000024781.8 3354.957633 0.569212846 0.144683254 3.934199913 8.35E-05 0.002960456 11.48979824 12.0726426 2 Lipe ENSMUSG00000003123.9 2725.925145 -0.936290248 0.186475188 -5.020991053 5.14E-07 3.35E-05 11.91482919 10.93034953 2 Lox ENSMUSG00000024529.6 20434.71931 0.774209497 0.15285797 5.064894533 4.09E-07 2.75E-05 13.84202469 14.69209794 2 Loxl1 ENSMUSG00000032334.8 19571.87954 -0.480182094 0.142046553 -3.380455798 0.000723657 0.018984376 14.50643221 13.99037646 2 Lpar4 ENSMUSG00000049929.7 1321.854459 0.871912511 0.164386972 5.304024409 1.13E-07 8.59E-06 10.12127029 10.95784155 2 Lpin1 ENSMUSG00000020593.7 1759.414503 -0.677652645 0.173906369 -3.896652245 9.75E-05 0.00336167 11.26926835 10.55556517 2 Ltbp1 ENSMUSG00000001870.8 4482.845216 0.556710483 0.163955162 3.395504446 0.000685023 0.01815025 11.86523955 12.46591981 2 Ly6a ENSMUSG00000075602.4 4707.273495 0.785863199 0.14787096 5.314520159 1.07E-07 8.15E-06 11.79617926 12.62724827 2 Ly6c1 ENSMUSG00000079018.3 1324.223597 1.214082779 0.15847766 7.66090806 1.85E-14 4.14E-12 9.917574545 11.06732622 2 Ly6c2 ENSMUSG00000022584.8 450.4650203 1.197541632 0.18062146 6.630118202 3.35E-11 4.90E-09 8.838231677 9.787247068 2 Ly6e ENSMUSG00000022587.7 5083.908923 0.68496447 0.141259474 4.848980751 1.24E-06 7.51E-05 11.974916 12.69242982 2 Magel2 ENSMUSG00000056972.5 23.25447411 1.07785212 0.231744307 4.651040344 3.30E-06 0.000176438 7.093814077 7.799515936 2 Man2b1 ENSMUSG00000005142.9 4760.195048 0.822991747 0.148299536 5.549523412 2.86E-08 2.41E-06 11.78943157 12.65261962 2 Mapk6 ENSMUSG00000042688.10 9348.09002 -0.649947179 0.156623889 -4.149732104 3.33E-05 0.001295975 13.52748607 12.82584133 2 Mctp1 ENSMUSG00000021596.9 25.88943574 0.811207532 0.236324252 3.432603829 0.000597815 0.016134924 7.284302447 7.789578792 2 Mdfic ENSMUSG00000041390.11 1018.392081 0.708249448 0.163355833 4.335623878 1.45E-05 0.000630657 9.921994577 10.57709555 2 Mdh2 ENSMUSG00000019179.6 6628.243198 -0.439418429 0.139844568 -3.142191624 0.001676882 0.037929939 12.95712045 12.49609775 2 Megf6 ENSMUSG00000057751.7 223.2194213 -1.015557517 0.218864848 -4.640112496 3.48E-06 0.000181805 9.066852408 8.331525565 2 Mfge8 ENSMUSG00000030605.9 2429.209365 0.635855289 0.147329435 4.315874076 1.59E-05 0.000679347 11.02423184 11.66628343 2 Mgp ENSMUSG00000030218.1 927.3254265 -0.940244947 0.17386262 -5.407976417 6.37E-08 5.15E-06 10.54896239 9.667157517 2 Mgst3 ENSMUSG00000026688.5 2524.026931 -1.227267159 0.158801311 -7.728318807 1.09E-14 2.51E-12 11.91592433 10.67349753 2 Mid2 ENSMUSG00000000266.5 249.7133371 1.825311957 0.212209875 8.601446817 7.87E-18 2.79E-15 8.067130423 9.321764554 2 Mmp9 ENSMUSG00000017737.2 152.6933758 1.32836176 0.236789839 5.609876528 2.02E-08 1.75E-06 7.905143908 8.837942001 2 Mocs1 ENSMUSG00000064120.7 4404.234492 -0.525049252 0.138513088 -3.790611123 0.000150277 0.004893686 12.42770023 11.88446237 2 Mrc2 ENSMUSG00000020695.8 13967.30215 0.67423132 0.133063974 5.066971166 4.04E-07 2.74E-05 13.39182683 14.10922669 2 Mrpl41 ENSMUSG00000036850.3 351.3820728 -0.809154391 0.190242562 -4.253277412 2.11E-05 0.000857959 9.429035493 8.80649033 2 Mrps6 ENSMUSG00000039680.8 4144.943484 -0.558183631 0.143148391 -3.899335683 9.65E-05 0.003339089 12.35958194 11.77760553 2 Msln ENSMUSG00000063011.6 286.7835655 0.76877112 0.224748844 3.420578754 0.00062488 0.016751844 8.612305505 9.215098949 2 Msx1 ENSMUSG00000048450.9 680.7024694 -0.563000951 0.173336407 -3.248024812 0.001162091 0.027911226 10.05104846 9.557256026 2 Mtap1b ENSMUSG00000052727.4 378.9444751 1.108441393 0.214149784 5.176009857 2.27E-07 1.61E-05 8.666026529 9.599900755 2 Mtap7d2 ENSMUSG00000041020.7 997.1610323 -0.930379554 0.166801125 -5.577777455 2.44E-08 2.06E-06 10.62718153 9.765962905 2 Mtap9 ENSMUSG00000033900.7 509.633875 -0.665690484 0.176241438 -3.777150767 0.000158633 0.005113497 9.766911564 9.217370947 2 Mum1l1 ENSMUSG00000042515.6 930.5058074 0.66935623 0.202135606 3.311421688 0.000928232 0.023574432 9.80381066 10.43610472 2 Mx1 ENSMUSG00000000386.8 188.9695208 3.061386857 0.233414684 13.11565667 2.68E-39 1.07E-35 7.381936122 9.186638321 2 Mx2 ENSMUSG00000023341.8 114.7528525 2.376523917 0.245855822 9.666331673 4.19E-22 2.78E-19 7.327883065 8.730833973 2 Myo10 ENSMUSG00000022272.11 1747.126217 -0.937015992 0.154647251 -6.05905368 1.37E-09 1.54E-07 11.34195569 10.41798755 2 Myo7a ENSMUSG00000030761.9 581.8271658 0.692723814 0.189479942 3.655921615 0.00025626 0.007757944 9.310659684 9.925430092 2 Naaa ENSMUSG00000029413.7 2691.650178 -0.929216778 0.147997784 -6.278585755 3.42E-10 4.39E-08 11.90886958 10.97131329 2 Naip1 ENSMUSG00000021640.5 86.39558074 0.774264907 0.242630015 3.191134071 0.001417155 0.033186436 7.849586421 8.321976531 2 Naip2 ENSMUSG00000078945.3 366.7183954 0.922321362 0.19176745 4.809582444 1.51E-06 8.82E-05 8.78499352 9.505863327 2 Naip5 ENSMUSG00000071203.5 143.2013195 0.955684486 0.227829402 4.194737282 2.73E-05 0.001093027 8.073073444 8.696706473 2 Nampt ENSMUSG00000020572.7 3518.783217 -0.528487125 0.144844762 -3.648645048 0.000263627 0.007950752 12.12034154 11.57816604 2 Narf ENSMUSG00000000056.7 1379.214051 0.484180306 0.152364435 3.177777707 0.001484085 0.034399662 10.40565326 10.87043286 2 Nat8l ENSMUSG00000048142.8 29.14848083 -0.827575747 0.23661328 -3.497587906 0.000469486 0.013070095 7.827056831 7.302847184 2 Nbl1 ENSMUSG00000041120.6 1730.528983 -0.459287215 0.150154687 -3.058760433 0.002222548 0.047790742 11.14821044 10.69984352 2 Ncam1 ENSMUSG00000039542.8 2004.190231 0.618781756 0.157980326 3.916827942 8.97E-05 0.00314698 10.78065515 11.40660288 2 Nckap5 ENSMUSG00000049690.8 30.37566309 0.801307195 0.242742003 3.301065271 0.000963185 0.024040366 7.362145668 7.842440154 2 Ndn ENSMUSG00000033585.4 1960.677614 1.542591226 0.146023903 10.56396379 4.38E-26 4.98E-23 10.17097469 11.66219525 2 Ndrg1 ENSMUSG00000005125.6 197.3958841 1.231877425 0.219990151 5.599693537 2.15E-08 1.84E-06 8.15272206 9.015941433 2 Ndrg2 ENSMUSG00000004558.8 155.9661584 -0.818497059 0.230182322 -3.555864116 0.000376739 0.01082886 8.726273742 8.17041505 2 Nfe2l1 ENSMUSG00000038615.10 10308.58141 0.451006428 0.138175788 3.26400475 0.001098493 0.026624667 13.10303501 13.58535547 2 Nfkbie ENSMUSG00000023947.7 234.7827837 1.32014536 0.213505425 6.183193515 6.28E-10 7.52E-08 8.239606119 9.180009256 2 Ngf ENSMUSG00000027859.4 80.94567174 0.851031797 0.244581539 3.479542239 0.000502271 0.01386164 7.782633774 8.301731204 2 Ngfrap1 ENSMUSG00000046432.5 661.1920098 0.643065287 0.17952484 3.582040726 0.000340921 0.009924717 9.479222474 10.0481428 2 Nhsl1 ENSMUSG00000039835.9 111.8640773 1.113448002 0.241980158 4.601402087 4.20E-06 0.000216257 7.830609471 8.567375718 2 Nolc1 ENSMUSG00000015176.8 4001.605382 -0.556302569 0.158039868 -3.52001414 0.000431524 0.012270687 12.30703521 11.72188826 2 Nop2 ENSMUSG00000038279.8 2623.100954 -0.502476963 0.162650216 -3.089310153 0.002006219 0.044004171 11.71133082 11.19409477 2 Nox4 ENSMUSG00000030562.9 345.3177584 0.743275539 0.189475458 3.922806405 8.75E-05 0.003090297 8.822889111 9.393222602 2 Npy1r ENSMUSG00000036437.5 234.1163594 2.206084938 0.213698374 10.32335856 5.53E-25 4.63E-22 7.875208942 9.310298645 2 Nqo1 ENSMUSG00000003849.8 841.1793447 -1.201687112 0.194242354 -6.186534935 6.15E-10 7.47E-08 10.51160187 9.36793799 2 Nrbp2 ENSMUSG00000075590.2 512.2821992 -0.61682854 0.18703377 -3.297952769 0.000973925 0.024270398 9.758063261 9.233603925 2 Nt5c2 ENSMUSG00000025041.9 2265.010933 -0.484781644 0.149409152 -3.244658301 0.001175916 0.028158334 11.51202002 11.02367082 2 Ntn1 ENSMUSG00000020902.6 2116.348557 0.555081795 0.160611625 3.456049921 0.000548154 0.014921027 10.8895448 11.44776173 2 Nup107 ENSMUSG00000052798.6 3858.20072 1.113930782 0.154005602 7.233053644 4.72E-13 8.85E-11 11.29380641 12.46942714 2 Nupr1 ENSMUSG00000030717.3 396.558226 0.616629734 0.189838766 3.248176056 0.001161474 0.027911226 8.996656857 9.49372127 2 Oaf ENSMUSG00000032014.5 7368.720517 -0.846129485 0.182095073 -4.646635802 3.37E-06 0.000177955 13.27231299 12.31080827 2 Oas1a ENSMUSG00000052776.9 42.0455623 1.250081704 0.238902781 5.232595877 1.67E-07 1.23E-05 7.155458997 8.036590374 2 Oas1b ENSMUSG00000029605.8 63.55424957 1.10464179 0.248020861 4.453826121 8.44E-06 0.000390478 7.579609883 8.213546947 2 Oas1g ENSMUSG00000066861.7 28.79097103 1.023503953 0.230130251 4.447498528 8.69E-06 0.00040099 7.128720483 7.855693499 2 Oas2 ENSMUSG00000032690.9 28.47329219 1.231354161 0.234025523 5.261623367 1.43E-07 1.06E-05 7.009378459 7.885374174 2 Oasl2 ENSMUSG00000029561.10 349.0063007 2.568232651 0.235510952 10.90493936 1.09E-27 1.45E-24 7.748449595 9.720260025 2 Ogn ENSMUSG00000021390.5 585.5190932 1.28973928 0.217291291 5.935531386 2.93E-09 3.09E-07 8.878242145 10.14286993 2 Olfml3 ENSMUSG00000027848.9 2402.655722 0.694217658 0.184327806 3.766212346 0.000165743 0.005321147 10.93997739 11.65961054 Page 53 of 79 Diabetes
2 Orm2 ENSMUSG00000061540.3 599.7091552 0.710380575 0.190370958 3.731559601 0.000190298 0.005988745 9.336511922 9.958042246 2 Oxct1 ENSMUSG00000022186.8 6577.644777 -0.528988155 0.138651265 -3.815242192 0.000136049 0.004494712 12.9859568 12.43025907 2 Pak3 ENSMUSG00000031284.9 989.9655426 0.688384411 0.164401897 4.187204783 2.82E-05 0.001125932 9.899811741 10.53660423 2 Palld ENSMUSG00000058056.8 1754.42886 0.769621305 0.154094453 4.994477664 5.90E-07 3.82E-05 10.52964421 11.28754708 2 Pank3 ENSMUSG00000018846.8 15153.74879 -0.4251448 0.137676539 -3.087997431 0.002015102 0.044138221 14.11908758 13.66336456 2 Pappa2 ENSMUSG00000073530.4 709.7207976 1.469273707 0.196904876 7.461845218 8.53E-14 1.76E-11 9.0472604 10.3619388 2 Paqr4 ENSMUSG00000023909.3 468.2295654 -1.060679986 0.183386593 -5.783846957 7.30E-09 7.00E-07 9.793599164 8.935693343 2 Parp1 ENSMUSG00000026496.6 4078.689219 -0.673948487 0.147415919 -4.571748351 4.84E-06 0.000243734 12.38135339 11.68230555 2 Parp12 ENSMUSG00000038507.6 974.4462353 0.602511824 0.166863919 3.610797514 0.000305257 0.008985048 9.929458785 10.48401726 2 Parp14 ENSMUSG00000034422.8 574.9839979 2.355990368 0.189136369 12.45656975 1.29E-35 3.42E-32 8.406759776 10.27693492 2 Parp9 ENSMUSG00000022906.8 636.4481935 0.894801838 0.172151475 5.197758763 2.02E-07 1.45E-05 9.318203574 10.08432131 2 Pbx1 ENSMUSG00000052534.7 1575.396663 -0.479896166 0.157361404 -3.049643396 0.002291132 0.048906154 11.03718619 10.56594096 2 Pcdh19 ENSMUSG00000051323.9 2192.842428 0.526891355 0.172491211 3.054598269 0.002253622 0.048212978 10.93430621 11.48764594 2 Pcdh9 ENSMUSG00000055421.2 152.2490824 0.832651211 0.232606015 3.579663275 0.000344037 0.00999717 8.144363643 8.711806143 2 Pck2 ENSMUSG00000040618.5 1567.343717 0.690208288 0.191872392 3.597225633 0.000321629 0.009414757 10.4021062 11.09740202 2 Pcolce2 ENSMUSG00000015354.8 268.5890581 -0.954327273 0.212176398 -4.497801269 6.87E-06 0.000327347 9.212736923 8.500370536 2 Pcx ENSMUSG00000024892.8 24685.99223 -1.02126772 0.145730485 -7.007920972 2.42E-12 4.05E-10 15.05019301 13.94275791 2 Pde1a ENSMUSG00000059173.10 1790.739451 0.673683611 0.147166089 4.577709558 4.70E-06 0.000237644 10.61980416 11.27729825 2 Pde7b ENSMUSG00000019990.8 340.3498442 1.135986586 0.200831458 5.656417546 1.55E-08 1.39E-06 8.611044516 9.485536086 2 Pdgfrb ENSMUSG00000024620.5 2853.255736 0.69487281 0.154073569 4.51000657 6.48E-06 0.000311868 11.18809201 11.90625507 2 Pdgfrl ENSMUSG00000031595.9 378.8884777 0.756997545 0.194080942 3.900421847 9.60E-05 0.003331385 8.886204661 9.492481988 2 Pdlim2 ENSMUSG00000022090.4 759.96662 0.917089366 0.177657528 5.162119359 2.44E-07 1.71E-05 9.468174079 10.30383856 2 Peg10 ENSMUSG00000092035.1 18961.83414 -1.246047683 0.154348685 -8.07294005 6.86E-16 1.85E-13 14.74649175 13.38171069 2 Peli2 ENSMUSG00000021846.7 5850.668099 -0.651627139 0.138976087 -4.688771664 2.75E-06 0.000149887 12.87405264 12.19024188 2 Pex11a ENSMUSG00000030545.7 681.4723837 -1.072085036 0.173243055 -6.1883291 6.08E-10 7.45E-08 10.21539796 9.287215062 2 Phactr1 ENSMUSG00000054728.9 144.50975 0.765815488 0.226667675 3.378582714 0.000728605 0.019062723 8.154173349 8.658426874 2 Phlda3 ENSMUSG00000041801.5 4472.026869 -0.451630159 0.1393307 -3.241426027 0.001189333 0.02839421 12.41737476 11.94912075 2 Pi15 ENSMUSG00000067780.2 4670.371803 0.829821808 0.154494443 5.371208115 7.82E-08 6.17E-06 11.74963976 12.63155855 2 Pik3r5 ENSMUSG00000020901.7 543.1550511 0.628301623 0.192163882 3.2696135 0.001076945 0.026222134 9.277314392 9.826262641 2 Pim3 ENSMUSG00000035828.9 2578.551076 -0.615661033 0.183485323 -3.355369364 0.000792591 0.020555726 11.73108608 11.07566457 2 Pkp1 ENSMUSG00000026413.6 64.02968555 -1.212683006 0.248283738 -4.884262714 1.04E-06 6.41E-05 8.234374844 7.541421861 2 Pla1a ENSMUSG00000002847.6 54.60765855 1.255495587 0.249396243 5.034139936 4.80E-07 3.17E-05 7.443424701 8.160478351 2 Pla2g16 ENSMUSG00000060675.7 272.5568357 -1.110416908 0.207675581 -5.346882405 8.95E-08 6.92E-06 9.265898878 8.449061304 2 Plat ENSMUSG00000031538.5 1144.729321 0.886583009 0.183427451 4.833426006 1.34E-06 7.97E-05 9.921408096 10.78172583 2 Plekha6 ENSMUSG00000041757.8 205.4734838 -0.761619246 0.216070463 -3.524865158 0.000423698 0.01206972 8.927541641 8.395414947 2 Plekhg5 ENSMUSG00000039713.10 1153.534021 -0.482952968 0.156467899 -3.086594566 0.002024635 0.044286117 10.64594807 10.19347758 2 Plekho2 ENSMUSG00000050721.8 1355.064406 0.64522558 0.157246177 4.103283104 4.07E-05 0.001551745 10.2897212 10.91118234 2 Plin1 ENSMUSG00000030546.7 568.7563131 -1.49426143 0.19878498 -7.5169735 5.61E-14 1.19E-11 10.11019418 8.837433491 2 Plin4 ENSMUSG00000002831.7 5787.073691 -0.833816847 0.136047203 -6.128879018 8.85E-10 1.02E-07 12.92777207 12.05884827 2 Plk2 ENSMUSG00000021701.7 1384.948299 0.533283371 0.160773405 3.316987481 0.000909937 0.023220891 10.37555996 10.89692141 2 Plod2 ENSMUSG00000032374.8 2424.465766 0.658079024 0.14802483 4.445734022 8.76E-06 0.000403127 11.0093802 11.67067329 2 Plscr1 ENSMUSG00000032369.7 948.5020422 0.546482859 0.160826705 3.397960926 0.000678901 0.018048117 9.932109906 10.43319201 2 Pnp ENSMUSG00000021871.10 5567.084181 0.443673498 0.137903382 3.21727786 0.001294132 0.030484849 12.25307391 12.71733265 2 Pnpla2 ENSMUSG00000025509.8 5128.385218 -1.256268955 0.154490069 -8.131713323 4.23E-16 1.18E-13 12.89814414 11.5736239 2 Pnpla8 ENSMUSG00000036257.8 1883.219241 -0.538182223 0.147934459 -3.637977438 0.000274787 0.008226771 11.289715 10.76179422 2 Polr2l ENSMUSG00000038489.8 1266.5699 -0.502146425 0.152536014 -3.291986025 0.000994826 0.024752503 10.76984815 10.29512341 2 Pop1 ENSMUSG00000022325.8 740.8083673 -0.587524545 0.17787046 -3.303103539 0.000956211 0.023935816 10.1557052 9.629579276 2 Porcn ENSMUSG00000031169.7 1077.687234 0.823526604 0.157989861 5.212528186 1.86E-07 1.34E-05 9.924951077 10.68571316 2 Ppa1 ENSMUSG00000020089.7 1025.498029 -0.77413663 0.195544794 -3.958871073 7.53E-05 0.002700799 10.59701645 9.85515393 2 Pparg ENSMUSG00000000440.6 2326.705101 -0.615252124 0.169121814 -3.63792292 0.000274846 0.008226771 11.59776343 10.9630547 2 Ppargc1b ENSMUSG00000033871.8 122.8629985 -1.114252753 0.240762597 -4.628014352 3.69E-06 0.000190875 8.618943203 7.887249936 2 Ppef1 ENSMUSG00000062168.6 41.47314738 0.950143179 0.234175563 4.057396802 4.96E-05 0.001837657 7.239766486 8.007711138 2 Ppp1r12b ENSMUSG00000073557.4 1286.025692 0.694856944 0.166327161 4.17765169 2.95E-05 0.001160931 10.18909187 10.86558816 2 Ppp1r1b ENSMUSG00000061718.6 128.845713 -2.526159931 0.242127562 -10.43317792 1.75E-25 1.86E-22 8.83207395 7.364415581 2 Ppp2r1b ENSMUSG00000032058.7 6096.777311 -0.551890399 0.174761003 -3.157972255 0.001588707 0.036400815 12.87739534 12.2840566 2 Prdm11 ENSMUSG00000075028.4 306.434541 0.713809117 0.197824471 3.608295341 0.000308216 0.009055394 8.729491925 9.271536596 2 Prg4 ENSMUSG00000006014.9 4405.34525 0.698431331 0.163114012 4.281859795 1.85E-05 0.000772596 11.74914313 12.50019843 2 Prkaa1 ENSMUSG00000050697.8 2659.251691 -0.556165319 0.143187286 -3.884180875 0.000102675 0.003531326 11.7536644 11.19402128 2 Prkd1 ENSMUSG00000002688.7 71.1235089 2.134678295 0.248711137 8.582962227 9.25E-18 3.20E-15 7.23086758 8.400166885 2 Prl2c2 ENSMUSG00000079092.2 582.9152535 -0.750960608 0.19142757 -3.922949081 8.75E-05 0.003090297 9.951496763 9.275893397 2 Prl2c3 ENSMUSG00000056457.5 491.3607315 -0.703239216 0.197448735 -3.561629381 0.00036856 0.010651463 9.750913239 9.130948162 2 Prl2c5 ENSMUSG00000055360.7 120.674999 -0.787880142 0.240060282 -3.282009563 0.001030701 0.025289498 8.547349576 8.003049482 2 Prps2 ENSMUSG00000025742.5 1318.948186 0.487767611 0.159111327 3.065574403 0.002172523 0.047196806 10.34475409 10.81681706 2 Prune2 ENSMUSG00000039126.8 9910.990596 0.746565786 0.19045968 3.919810147 8.86E-05 0.003122046 12.76605652 13.6588837 2 Psd3 ENSMUSG00000030465.11 709.4334533 0.622227062 0.165633646 3.756646522 0.000172205 0.00549539 9.575968617 10.11941071 2 Psen2 ENSMUSG00000010609.9 1051.583511 -0.610377234 0.158165456 -3.859105826 0.000113803 0.003855731 10.58237516 10.01527047 2 Psmb10 ENSMUSG00000031897.8 474.2680741 0.880695725 0.182001501 4.838947604 1.31E-06 7.79E-05 9.036401812 9.759071928 2 Psmb8 ENSMUSG00000024338.8 42.46116303 1.029691439 0.246721114 4.173503531 3.00E-05 0.001179363 7.382720635 8.01763356 2 Ptcd3 ENSMUSG00000063884.4 2218.823229 -0.466801454 0.150509682 -3.101471263 0.001925616 0.042411484 11.47590421 11.00847392 2 Ptgs2 ENSMUSG00000032487.7 180.8030512 1.045835304 0.218671765 4.782671893 1.73E-06 9.98E-05 8.189486549 8.895058064 2 Ptprj ENSMUSG00000025314.9 236.367775 0.844282307 0.204235836 4.13385977 3.57E-05 0.001378745 8.472395233 9.0701036 2 Ptprm ENSMUSG00000033278.8 475.7563122 -0.957746737 0.177715372 -5.389217194 7.08E-08 5.69E-06 9.782267965 9.008282951 2 Ptprq ENSMUSG00000035916.5 89.87005509 1.981812389 0.248931567 7.961273917 1.70E-15 4.37E-13 7.320101471 8.535517302 2 Pycr1 ENSMUSG00000025140.9 337.9975869 0.644760462 0.19809672 3.254776065 0.001134818 0.027380065 8.838105486 9.344616082 2 Rab12 ENSMUSG00000023460.6 449.7903455 -0.654961336 0.179071616 -3.65753854 0.000254649 0.007723867 9.631954446 9.103560991 2 Rab39b ENSMUSG00000031202.5 126.8297396 0.716480112 0.230802447 3.104300333 0.001907296 0.042066182 8.093434386 8.551022657 2 Ralgps2 ENSMUSG00000026594.7 124.3778594 1.03235802 0.230011617 4.488286442 7.18E-06 0.00033627 7.967075452 8.608556012 2 Ramp3 ENSMUSG00000041046.7 147.4283773 0.840066908 0.240769644 3.489089798 0.000484668 0.013445746 8.09490888 8.684820394 2 Rap1gap2 ENSMUSG00000038807.10 478.657253 -1.005220313 0.191643425 -5.245263769 1.56E-07 1.15E-05 9.801734638 8.969832757 2 Rap2c ENSMUSG00000050029.7 2132.677118 0.515734663 0.146723363 3.515013915 0.000439731 0.012437434 10.93222374 11.44383138 2 Rasgef1b ENSMUSG00000029333.8 62.42775399 -1.477192551 0.249262314 -5.92625706 3.10E-09 3.25E-07 8.262343313 7.407830846 2 Rassf2 ENSMUSG00000027339.9 3007.41186 0.677346361 0.170343022 3.976366939 7.00E-05 0.002538268 11.25622125 11.96165854 2 Rbp1 ENSMUSG00000046402.9 215.8375417 1.137951415 0.224344135 5.072347518 3.93E-07 2.67E-05 8.240578984 9.0680338 2 Rcl1 ENSMUSG00000024785.6 2496.358569 -0.465342639 0.149669891 -3.109126609 0.001876413 0.041557718 11.63223841 11.16083627 2 Rcor2 ENSMUSG00000024968.6 406.2802283 -0.670395638 0.196205777 -3.416798674 0.000633621 0.01695762 9.535159995 8.985127514 2 Retn ENSMUSG00000012705.9 167.6619739 -1.228950336 0.229748 -5.349123111 8.84E-08 6.87E-06 8.87099153 8.044329779 Diabetes Page 54 of 79
2 Retnla ENSMUSG00000061100.3 1659.120182 1.24850113 0.174561779 7.152202131 8.54E-13 1.51E-10 10.12540541 11.36437962 2 Retsat ENSMUSG00000056666.6 1436.063226 -0.55080792 0.167621078 -3.286030167 0.001016101 0.025047054 10.94298654 10.40869845 2 Rilpl2 ENSMUSG00000029401.7 1167.238657 -0.792103088 0.158181799 -5.007548882 5.51E-07 3.58E-05 10.77565724 10.03126597 2 Rin1 ENSMUSG00000024883.6 568.6216369 0.662406829 0.201493798 3.287479984 0.001010884 0.024995827 9.295694152 9.879370971 2 Rnase4 ENSMUSG00000021876.8 2976.81153 0.628411879 0.146902345 4.277752543 1.89E-05 0.000783051 11.29423731 11.93446419 2 Rnd2 ENSMUSG00000001313.6 187.558697 -0.736303917 0.215837143 -3.411386497 0.000646334 0.017268831 8.847794013 8.344835307 2 Rnf128 ENSMUSG00000031438.5 142.4349698 -0.721281827 0.227332898 -3.17280004 0.001509765 0.034842743 8.635492388 8.162341579 2 Rnf213 ENSMUSG00000070327.6 4658.861283 1.653523146 0.171418031 9.646144805 5.10E-22 3.25E-19 11.07571916 12.89042919 2 Robo1 ENSMUSG00000022883.9 84.03743957 2.310582015 0.248159981 9.310856666 1.27E-20 5.94E-18 7.207530465 8.519349935 2 Robo2 ENSMUSG00000052516.11 95.2379945 1.345230825 0.247302623 5.439614069 5.34E-08 4.38E-06 7.428110083 8.507014856 2 Rpia ENSMUSG00000053604.5 691.4948828 -0.576543882 0.167109656 -3.450093168 0.000560393 0.015176361 10.07386085 9.572008097 2 Rps6ka1 ENSMUSG00000003644.11 266.0001053 -0.881382801 0.216369425 -4.073509014 4.63E-05 0.00174336 9.184635199 8.519930777 2 Rpusd3 ENSMUSG00000051169.8 454.2940821 -1.016974526 0.1887778 -5.387151073 7.16E-08 5.70E-06 9.751408315 8.922479373 2 Rrad ENSMUSG00000031880.6 80.34108274 0.827523739 0.247869017 3.338552544 0.000842161 0.021699955 7.750446178 8.3067625 2 Rreb1 ENSMUSG00000039087.9 2550.603918 -0.631496128 0.146365758 -4.314507262 1.60E-05 0.000679347 11.72810708 11.09201799 2 Rrm2 ENSMUSG00000020649.5 1124.598491 -0.754309955 0.211407964 -3.568029982 0.000359675 0.010413582 10.7177059 9.91421422 2 Rsad2 ENSMUSG00000020641.8 16.03151289 0.706504977 0.209749482 3.368327639 0.000756257 0.019709707 7.093814077 7.631793285 2 Rspo3 ENSMUSG00000019880.9 31.7809769 0.927497374 0.239044018 3.880027542 0.000104445 0.003576723 7.285041353 7.885354577 2 Rtp4 ENSMUSG00000033355.5 134.7227258 1.905712337 0.243987584 7.810693901 5.69E-15 1.37E-12 7.563418215 8.818570386 2 Rxra ENSMUSG00000015846.8 15215.67607 -0.432864628 0.137704424 -3.143432979 0.001669786 0.037877037 14.12737461 13.66531889 2 Saa3 ENSMUSG00000040026.7 178.9922343 1.347076278 0.225182645 5.982149633 2.20E-09 2.39E-07 8.041901763 8.949527044 2 Samd14 ENSMUSG00000047181.6 728.4512712 0.557612555 0.164367374 3.392477112 0.000692637 0.018321519 9.637770408 10.12681685 2 Samd4 ENSMUSG00000021838.10 237.8193854 1.2113884 0.210338516 5.759232427 8.45E-09 7.96E-07 8.301585183 9.169669447 2 Samd9l ENSMUSG00000047735.10 1461.025634 0.777352823 0.172137212 4.515890624 6.31E-06 0.000305175 10.27808823 11.06159781 2 Samsn1 ENSMUSG00000022876.10 28.73032027 1.085889821 0.240079936 4.523034448 6.10E-06 0.000297766 7.214078015 7.868520652 2 Sav1 ENSMUSG00000021067.7 4574.499928 -0.58033195 0.141232261 -4.109060821 3.97E-05 0.001524374 12.50349387 11.89916011 2 Scarb1 ENSMUSG00000037936.9 589.3800859 -1.114399776 0.172222444 -6.470700043 9.75E-11 1.32E-08 10.06011896 9.129178889 2 Scd1 ENSMUSG00000037071.2 14781.5985 -1.227195492 0.148034807 -8.289911807 1.13E-16 3.34E-14 14.38460976 13.0584303 2 Scd2 ENSMUSG00000025203.5 46333.46498 -0.553223695 0.131450968 -4.208593553 2.57E-05 0.001033311 15.7743741 15.17936689 2 Scd3 ENSMUSG00000025202.6 2001.459497 -0.686396431 0.157054093 -4.370445975 1.24E-05 0.000556187 11.4297103 10.73937078 2 Scd4 ENSMUSG00000050195.8 888.0171854 -0.666433433 0.185732886 -3.588128347 0.00033306 0.009731473 10.40592482 9.760869522 2 Scp2 ENSMUSG00000028603.9 6740.158534 -0.62313372 0.144418984 -4.314763228 1.60E-05 0.000679347 13.0579959 12.40097033 2 Scp2-ps2 ENSMUSG00000058492.4 877.9408802 -0.630362521 0.165644277 -3.805519462 0.000141507 0.004636534 10.37114731 9.798728184 2 Scpep1 ENSMUSG00000000278.9 3853.277314 0.714873791 0.15372308 4.650399868 3.31E-06 0.000176438 11.57549594 12.31739669 2 Sdpr ENSMUSG00000045954.6 853.4697425 0.636833771 0.181662885 3.505579976 0.000455614 0.012773223 9.752601596 10.33448902 2 Sec24d ENSMUSG00000039234.7 2423.736193 0.604968975 0.153722779 3.935454333 8.30E-05 0.002951608 11.03269913 11.65328965 2 Selm ENSMUSG00000075702.9 720.535255 0.578799476 0.165800898 3.490930893 0.000481341 0.013376736 9.61452064 10.12190161 2 Sema5a ENSMUSG00000022231.8 2618.562021 1.094487729 0.14766348 7.412040742 1.24E-13 2.51E-11 10.82404907 11.92819403 2 Sema6a ENSMUSG00000019647.9 129.0840794 2.059048574 0.239128087 8.610651314 7.26E-18 2.63E-15 7.557022641 8.796519693 2 Sephs2 ENSMUSG00000049091.5 444.6353921 -0.610059406 0.1955441 -3.119804724 0.00180971 0.040248348 9.607129463 9.096186481 2 Sepp1 ENSMUSG00000064373.5 9943.605537 0.440886888 0.138580684 3.181445452 0.001465421 0.03421608 13.0579608 13.53042159 2 Serpine1 ENSMUSG00000037411.4 2233.716484 -0.640299097 0.191382301 -3.34565471 0.000820885 0.021242994 11.54286538 10.8680022 2 Serpinf1 ENSMUSG00000000753.8 5009.294906 1.134357399 0.150673285 7.528590097 5.13E-14 1.10E-11 11.63145083 12.83527163 2 Setd8 ENSMUSG00000049327.10 3021.555434 -0.523772462 0.149083632 -3.513279462 0.000442612 0.01248473 11.91098496 11.37726551 2 Sh2b2 ENSMUSG00000005057.9 523.4236014 -0.895132364 0.209789282 -4.26681647 1.98E-05 0.000815877 9.85989825 9.077335157 2 Sh3pxd2b ENSMUSG00000040711.7 7950.365347 0.727562564 0.135371555 5.374560147 7.68E-08 6.08E-06 12.56673961 13.33271203 2 Shc1 ENSMUSG00000042626.7 7031.063237 -0.496138733 0.142697759 -3.476850203 0.000507341 0.013953197 13.06778129 12.53742229 2 Sirpa ENSMUSG00000037902.11 569.8338211 0.62861092 0.177305063 3.545363631 0.000392072 0.011249282 9.342424202 9.875331746 2 Slc10a6 ENSMUSG00000029321.1 255.1233113 0.658883624 0.200339562 3.288834299 0.001006032 0.024953363 8.610154437 9.08657974 2 Slc1a3 ENSMUSG00000005360.8 1717.232336 -1.495881915 0.178215176 -8.393684243 4.71E-17 1.50E-14 11.48889782 9.970593628 2 Slc1a4 ENSMUSG00000020142.6 1100.589496 0.7818112 0.172913465 4.521401511 6.14E-06 0.000299155 9.956304831 10.69786905 2 Slc22a15 ENSMUSG00000033147.8 409.2639138 1.007381806 0.18810901 5.355308652 8.54E-08 6.67E-06 8.83972954 9.63877764 2 Slc25a10 ENSMUSG00000025792.3 1519.605327 -0.726839122 0.160218882 -4.536538471 5.72E-06 0.000283681 11.08820132 10.37412769 2 Slc25a22 ENSMUSG00000019082.9 846.0983982 -0.565456478 0.163401815 -3.460527525 0.000539118 0.014725415 10.30299 9.795700053 2 Slc27a1 ENSMUSG00000031808.6 706.0485271 -0.677452399 0.180080769 -3.7619364 0.000168603 0.005391231 10.12935276 9.532020449 2 Slc38a1 ENSMUSG00000023169.8 95.37699092 1.094088518 0.240201987 4.554868731 5.24E-06 0.000261664 7.787614959 8.445186432 2 Slc4a4 ENSMUSG00000060961.8 614.6884782 -0.699428676 0.16993982 -4.115743293 3.86E-05 0.001488041 9.984058876 9.386755174 2 Slc5a6 ENSMUSG00000006641.6 1266.147721 -1.773983042 0.189901667 -9.341587525 9.49E-21 5.21E-18 11.13670986 9.425817225 2 Slc6a14 ENSMUSG00000031089.7 39.44059295 0.892296901 0.246070475 3.626184337 0.00028764 0.008529572 7.405030953 7.96612031 2 Slc6a6 ENSMUSG00000030096.7 18320.52851 -0.886302353 0.146666286 -6.042986253 1.51E-09 1.67E-07 14.57846968 13.61502946 2 Slc6a9 ENSMUSG00000028542.10 115.3784013 0.870224706 0.238080914 3.655163663 0.000257018 0.007766137 7.967075452 8.522082569 2 Slc9a9 ENSMUSG00000031129.9 136.446043 0.892407449 0.236876229 3.767399757 0.000164957 0.005306608 8.038596893 8.657201265 2 Slfn2 ENSMUSG00000072620.3 159.7418799 0.783369906 0.241651115 3.241739252 0.001188027 0.02839421 8.149441493 8.74196192 2 Sms ENSMUSG00000071708.5 1715.7623 0.490654915 0.147893522 3.317622754 0.00090787 0.023205335 10.67225888 11.15073162 2 Snn ENSMUSG00000037972.6 1700.366416 -0.479516266 0.155148491 -3.090692433 0.001996904 0.043860267 11.13392298 10.66299142 2 Socs3 ENSMUSG00000053113.3 1536.232393 0.653680007 0.150396298 4.346383612 1.38E-05 0.000607132 10.4416824 11.07233017 2 Sorbs1 ENSMUSG00000025006.8 1508.236019 -0.547205394 0.156336959 -3.500166542 0.000464968 0.013012555 11.00987567 10.47420059 2 Sorbs3 ENSMUSG00000022091.5 719.1008336 0.616315711 0.17615325 3.498747313 0.000467449 0.013036188 9.585497544 10.13129003 2 Sorcs2 ENSMUSG00000029093.8 273.7457855 0.787713593 0.199751972 3.943458398 8.03E-05 0.002874011 8.607175255 9.187477667 2 Sort1 ENSMUSG00000068747.7 309.3409679 -1.001140714 0.200677325 -4.988808346 6.08E-07 3.90E-05 9.356370403 8.604681044 2 Sp100 ENSMUSG00000026222.9 110.910361 1.631538488 0.238154464 6.850757542 7.35E-12 1.18E-09 7.665138864 8.630887883 2 Sp110 ENSMUSG00000070034.7 44.47192825 0.825782391 0.249150981 3.314385462 0.000918448 0.023400585 7.517574471 7.99446927 2 Sp140 ENSMUSG00000070031.5 351.6555125 0.648798235 0.187547186 3.459386668 0.000541407 0.014762613 8.882638804 9.382210208 2 Specc1 ENSMUSG00000042331.7 608.508042 0.667411705 0.178258973 3.744056718 0.000181073 0.00573241 9.384887482 9.963100157 2 Sphk1 ENSMUSG00000061878.8 1878.931459 0.581386264 0.176954385 3.285514864 0.001017962 0.02505413 10.71128282 11.29622816 2 Spon2 ENSMUSG00000037379.4 1661.348758 0.649917996 0.166189312 3.91070875 9.20E-05 0.003206602 10.51821391 11.17747117 2 Spp1 ENSMUSG00000029304.8 695.1085406 1.206267121 0.177964242 6.778143218 1.22E-11 1.88E-09 9.223337817 10.27509959 2 Srpx2 ENSMUSG00000031253.9 869.8808482 1.221910873 0.209131375 5.842790789 5.13E-09 5.11E-07 9.341744922 10.55656893 2 Stambpl1 ENSMUSG00000024776.10 386.1168772 0.680702299 0.207015384 3.28817253 0.0010084 0.024973196 8.924584549 9.481474087 2 Stat1 ENSMUSG00000026104.7 2408.824316 0.608021942 0.172767733 3.519302661 0.000432683 0.012281713 11.00828849 11.6392742 2 Stat2 ENSMUSG00000040033.8 1050.677414 0.858601935 0.186817396 4.595942093 4.31E-06 0.00022058 9.842463519 10.66078112 2 Stbd1 ENSMUSG00000047963.5 40.70583177 0.840656221 0.247460203 3.397137041 0.000680949 0.018072375 7.453812381 7.965047912 2 Steap1 ENSMUSG00000015652.3 263.1885814 0.854071236 0.208100032 4.10413794 4.06E-05 0.001549727 8.539325944 9.167833389 2 Steap2 ENSMUSG00000015653.7 1995.022315 0.520422908 0.157551487 3.303192611 0.000955907 0.023935816 10.83268168 11.3626383 2 Stxbp1 ENSMUSG00000026797.9 1678.902388 0.509854334 0.15354127 3.320633826 0.000898133 0.022993357 10.62928988 11.13197847 2 Stxbp2 ENSMUSG00000004626.8 158.2061655 -0.804466396 0.221653335 -3.629389999 0.000284092 0.008455845 8.733557251 8.201853649 Page 55 of 79 Diabetes
2 Sulf2 ENSMUSG00000006800.7 6687.595333 -0.703605018 0.15928234 -4.417344799 9.99E-06 0.000453316 13.09144019 12.30957064 2 Sybu ENSMUSG00000022340.7 117.836112 0.878752589 0.238663782 3.681968758 0.00023144 0.007101054 7.970596572 8.539137314 2 Syne1 ENSMUSG00000019769.9 452.6445346 0.893081011 0.203576692 4.386951186 1.15E-05 0.000517083 8.945842959 9.728535926 2 Syt13 ENSMUSG00000027220.2 758.3909863 1.824276261 0.191715918 9.51551797 1.81E-21 1.03E-18 8.89653807 10.52666308 2 Taldo1 ENSMUSG00000025503.4 3022.526334 -0.917519597 0.162069327 -5.661278496 1.50E-08 1.36E-06 12.06026173 11.11157354 2 Tap1 ENSMUSG00000037321.9 689.6311637 0.807343813 0.173474128 4.653972451 3.26E-06 0.000175164 9.442153555 10.1500101 2 Tap2 ENSMUSG00000024339.6 500.868743 0.652226213 0.176644844 3.692302578 0.000222233 0.006871526 9.206823196 9.744379279 2 Tapbp ENSMUSG00000024308.7 5078.75545 0.622500981 0.138383071 4.498389708 6.85E-06 0.000327347 12.0165532 12.66524561 2 Tbc1d2 ENSMUSG00000039813.8 101.2684791 -0.782130009 0.242454632 -3.225881899 0.001255852 0.029699486 8.425962913 7.914281609 2 Tbc1d4 ENSMUSG00000033083.9 2187.913074 -0.817313101 0.145939385 -5.600360034 2.14E-08 1.84E-06 11.59353441 10.78184284 2 Tcf7l1 ENSMUSG00000055799.6 6356.795831 -0.480279056 0.138178044 -3.475798631 0.000509335 0.013983868 12.91709498 12.41391916 2 Tcf7l2 ENSMUSG00000024985.11 809.4663608 -1.184639804 0.163034371 -7.266196652 3.70E-13 7.09E-11 10.44756576 9.408255063 2 Tcirg1 ENSMUSG00000001750.9 1273.533047 0.572538554 0.161825581 3.537997839 0.000403173 0.011527336 10.25767396 10.80157707 2 Tead4 ENSMUSG00000030353.9 1256.425054 -0.507937252 0.153793252 -3.302727817 0.000957493 0.023935816 10.76203736 10.28168651 2 Tes ENSMUSG00000029552.12 655.9995399 0.812930739 0.180995557 4.491440304 7.07E-06 0.000332305 9.38105584 10.09390927 2 Tgfbi ENSMUSG00000035493.8 1648.40912 0.620119965 0.156234558 3.969160044 7.21E-05 0.002604402 10.54065819 11.15184627 2 Tgtp1 ENSMUSG00000078922.3 68.31301938 1.420574232 0.249046088 5.704061622 1.17E-08 1.08E-06 7.462890377 8.301574848 2 Tgtp2 ENSMUSG00000078921.3 74.70214213 1.423303937 0.248370891 5.730558562 1.00E-08 9.27E-07 7.506352878 8.352900467 2 Thbd ENSMUSG00000074743.3 4435.567652 0.750407068 0.145274537 5.165441132 2.40E-07 1.69E-05 11.74716582 12.5263502 2 Thbs1 ENSMUSG00000040152.8 2448.542386 1.446258549 0.16265157 8.891758938 6.01E-19 2.34E-16 10.47208931 11.93561158 2 Thbs2 ENSMUSG00000023885.7 4999.872639 1.376836679 0.137501321 10.01326144 1.33E-23 9.65E-21 11.47664394 12.89790913 2 Thy1 ENSMUSG00000032011.4 2961.38126 0.780691187 0.148260814 5.265660995 1.40E-07 1.04E-05 11.18750814 11.9885544 2 Timm9 ENSMUSG00000021079.8 309.0537295 -0.599668596 0.192184161 -3.120281053 0.001806786 0.040239516 9.243949816 8.792778641 2 Timp1 ENSMUSG00000001131.5 1561.041002 0.721814406 0.166743364 4.328894349 1.50E-05 0.000648469 10.4026373 11.12071231 2 Timp2 ENSMUSG00000017466.3 18201.80185 0.459842836 0.136475077 3.369427195 0.000753246 0.019663422 13.90102454 14.39688894 2 Tinagl1 ENSMUSG00000028776.6 1025.568283 -0.811599515 0.199497741 -4.068214061 4.74E-05 0.001770885 10.63946422 9.797871707 2 Tle3 ENSMUSG00000032280.9 1903.872226 -0.558812015 0.154602385 -3.614510966 0.000300915 0.008890115 11.31109128 10.75944771 2 Tll1 ENSMUSG00000053626.4 431.9959246 -0.722407679 0.189018548 -3.821887789 0.000132434 0.004400264 9.612342144 9.023716167 2 Tlr3 ENSMUSG00000031639.5 252.2098581 0.808643034 0.202022974 4.002728098 6.26E-05 0.002286929 8.53643333 9.118414544 2 Tm4sf1 ENSMUSG00000027800.8 1472.250752 1.119016981 0.152494155 7.338097507 2.17E-13 4.31E-11 10.10769691 11.1729153 2 Tmcc3 ENSMUSG00000020023.10 1328.220431 -1.122005468 0.167079258 -6.715408508 1.88E-11 2.84E-09 11.0495116 9.961609574 2 Tmem119 ENSMUSG00000054675.5 3714.595988 0.732343167 0.145108442 5.0468681 4.49E-07 2.99E-05 11.52192205 12.27580871 2 Tmem120a ENSMUSG00000039886.2 1602.939217 -0.773575256 0.199234981 -3.882728095 0.000103291 0.003544842 11.14860542 10.36462819 2 Tmem164 ENSMUSG00000047045.10 4392.869202 0.600112985 0.160638685 3.73579369 0.000187124 0.005900521 11.8191088 12.4505542 2 Tmem173 ENSMUSG00000024349.8 322.9030856 0.858581085 0.193586907 4.435119605 9.20E-06 0.000421076 8.71059626 9.361627406 2 Tmem176a ENSMUSG00000023367.8 4542.085098 0.550905869 0.145029507 3.798577816 0.000145529 0.00474877 11.9032673 12.48329094 2 Tmem176b ENSMUSG00000029810.8 6945.654756 0.515518013 0.141550462 3.641938047 0.000270593 0.008130049 12.51276571 13.05543727 2 Tmem19 ENSMUSG00000069520.5 1832.6837 0.468817031 0.149198325 3.142240575 0.001676602 0.037929939 10.76527584 11.22772663 2 Tnc ENSMUSG00000028364.8 3268.203625 0.656317147 0.206840817 3.173054312 0.001508443 0.034842743 11.30676618 12.0524815 2 Tnfrsf21 ENSMUSG00000023915.4 1659.99491 -1.075359985 0.184164766 -5.839118999 5.25E-09 5.19E-07 11.31163453 10.22464889 2 Tob1 ENSMUSG00000037573.5 4357.583962 -0.66838519 0.139694849 -4.784608715 1.71E-06 9.92E-05 12.4712517 11.77989447 2 Tpm1 ENSMUSG00000032366.9 2788.477036 0.594955427 0.144671025 4.112471206 3.91E-05 0.00150565 11.23093483 11.83334356 2 Traf1 ENSMUSG00000026875.7 39.96807276 1.138168154 0.247388192 4.600737584 4.21E-06 0.000216257 7.341162234 8.002794249 2 Trib1 ENSMUSG00000032501.8 1613.170187 0.584935722 0.15396567 3.799130805 0.000145204 0.004747917 10.53938435 11.10732446 2 Trib2 ENSMUSG00000020601.7 1303.32609 0.559289046 0.170158611 3.286868889 0.00101308 0.025011293 10.27600844 10.83405643 2 Trim25 ENSMUSG00000000275.9 3342.292942 0.477185745 0.148865939 3.205472983 0.001348407 0.031669666 11.53864803 12.02804895 2 Trim29 ENSMUSG00000032013.5 229.9895243 -1.082738231 0.230006884 -4.707416638 2.51E-06 0.000138233 9.118258696 8.27873999 2 Trim30a ENSMUSG00000030921.9 755.8225841 1.461163356 0.17594383 8.304714963 1.00E-16 3.01E-14 9.157676858 10.44173323 2 Trim30d ENSMUSG00000057596.7 178.2754905 1.404986659 0.227141213 6.185520641 6.19E-10 7.47E-08 8.008177813 8.962204928 2 Trim9 ENSMUSG00000021071.8 204.8444679 1.350698924 0.244947994 5.514227323 3.50E-08 2.92E-06 7.964839641 9.092884306 2 Tspan11 ENSMUSG00000030351.4 2021.580467 -0.758254159 0.167309989 -4.532031606 5.84E-06 0.000287119 11.4734344 10.69176902 2 Tspan7 ENSMUSG00000058254.6 164.244245 1.540476152 0.226930491 6.788317199 1.13E-11 1.77E-09 7.91662862 8.913905588 2 Twf1 ENSMUSG00000022451.6 2713.997326 -0.578991041 0.144006183 -4.020598473 5.81E-05 0.002129944 11.79119244 11.20524016 2 Txlng ENSMUSG00000038344.8 1281.865895 -0.525088698 0.153101522 -3.429676536 0.000604301 0.016254885 10.79426481 10.29586285 2 Uba7 ENSMUSG00000032596.7 187.2037979 0.80529183 0.21754422 3.70173856 0.000214127 0.006633777 8.310879021 8.867362816 2 Ube2l6 ENSMUSG00000027078.7 240.6937428 0.699837436 0.204047365 3.42977933 0.000604072 0.016254885 8.545872034 9.047550878 2 Ugt1a7c ENSMUSG00000090124.1 588.7597341 -0.575887579 0.177818304 -3.238629353 0.001201055 0.028588351 9.895273861 9.398599837 2 Unc5b ENSMUSG00000020099.6 2715.182401 -0.50410769 0.156772206 -3.215542484 0.001301982 0.030624468 11.76500155 11.23699081 2 Usp18 ENSMUSG00000030107.9 103.4355872 1.640250647 0.249411839 6.576474696 4.82E-11 6.97E-09 7.441898956 8.585239474 2 Usp46 ENSMUSG00000054814.8 1516.012203 -0.664012894 0.150058855 -4.425016393 9.64E-06 0.000440009 11.05875798 10.42030093 2 Vcam1 ENSMUSG00000027962.9 4060.85431 1.169147316 0.139800624 8.362962096 6.12E-17 1.91E-14 11.34872796 12.5492204 2 Vdr ENSMUSG00000022479.9 5436.85045 0.82450133 0.150370045 5.483148788 4.18E-08 3.45E-06 11.96100934 12.84295209 2 Vegfc ENSMUSG00000031520.4 1199.647878 1.037743216 0.17981877 5.771050577 7.88E-09 7.47E-07 9.878300247 10.89723831 2 Vipr1 ENSMUSG00000032528.4 107.8707211 -1.38422854 0.238254635 -5.809870358 6.25E-09 6.07E-07 8.576985299 7.740817838 2 Vldlr ENSMUSG00000024924.7 7572.466004 0.472698545 0.14370922 3.289270831 0.001004473 0.024953363 12.65428518 13.16143202 2 Vstm2a ENSMUSG00000048834.8 695.893163 -0.604201424 0.18140946 -3.330594906 0.000866606 0.022293759 10.09327039 9.548468165 2 Wnk4 ENSMUSG00000035112.10 975.2656637 -0.823034531 0.189740369 -4.337688053 1.44E-05 0.000628138 10.57819582 9.759755219 2 Wnt4 ENSMUSG00000036856.4 1717.486576 -0.695138127 0.146622 -4.741021998 2.13E-06 0.000120075 11.23086933 10.5562335 2 Wsb1 ENSMUSG00000017677.5 3995.368937 0.553369783 0.153413748 3.60704168 0.000309708 0.009082484 11.72706669 12.30264737 2 Xaf1 ENSMUSG00000040483.9 146.5905573 1.834337981 0.234997635 7.8057721 5.91E-15 1.41E-12 7.715482565 8.86365121 2 Xpnpep2 ENSMUSG00000037005.9 348.4415898 1.414899316 0.196801751 7.189465082 6.50E-13 1.16E-10 8.503122283 9.570588455 2 Yeats4 ENSMUSG00000020171.6 2622.50694 0.762646583 0.150567266 5.065155274 4.08E-07 2.75E-05 11.03939689 11.81821408 2 Zbp1 ENSMUSG00000027514.8 39.69923129 1.209423019 0.244826217 4.939924464 7.82E-07 4.92E-05 7.272642689 8.00912755 2 Zbtb7b ENSMUSG00000028042.8 1649.832807 -0.550082478 0.151971744 -3.619636547 0.000295017 0.008732068 11.12271476 10.58851154 2 Zc3hav1 ENSMUSG00000029826.8 2288.505657 0.489679286 0.156355082 3.13184118 0.001737138 0.039015781 11.03283815 11.52334088 2 Zfp385a ENSMUSG00000000552.8 3691.610035 -0.537440582 0.164590646 -3.26531667 0.001093418 0.026542046 12.18854335 11.61905137 2 Zfp658 ENSMUSG00000056592.7 572.5974334 0.650696143 0.174512942 3.728641184 0.000192515 0.006046567 9.33718672 9.889909296 2 Zkscan17 ENSMUSG00000020472.8 1045.25151 0.662828383 0.159287166 4.161216508 3.17E-05 0.001238538 9.980348443 10.59229185 4 1110021L09Rik ENSMUSG00000037455.9 927.0821259 -0.773649477 0.222756238 -3.473076592 0.000514528 0.024214068 10.33746946 9.575240961 4 1700008I05Rik ENSMUSG00000058252.6 39.87794639 1.721038895 0.372656855 4.618293943 3.87E-06 0.000326426 6.308963342 7.320606495 4 2010002M12Rik ENSMUSG00000067297.4 188.321762 3.825778411 0.332608851 11.50233496 1.28E-30 8.36E-28 6.300077536 8.849605322 4 2400009B08Rik ENSMUSG00000089665.1 188.4031974 -1.324978246 0.330908955 -4.004056781 6.23E-05 0.004041728 8.563912641 7.449563341 4 3110039M20Rik ENSMUSG00000089922.1 27.1109551 1.916994765 0.379659737 5.049244311 4.44E-07 4.25E-05 6.003797729 7.106777085 4 3830417A13Rik ENSMUSG00000031179.8 18.13187563 -1.324146651 0.371456286 -3.564744228 0.000364211 0.018360528 6.841207933 6.008601887 4 4632428N05Rik ENSMUSG00000020101.7 411.451974 -1.325668923 0.366228271 -3.619788613 0.000294844 0.015338471 9.387319923 7.934253564 4 4930528F23Rik ENSMUSG00000024155.7 26.57948386 1.632662967 0.37884561 4.309573404 1.64E-05 0.001221746 6.168700421 7.063660117 Diabetes Page 56 of 79
4 6330406I15Rik ENSMUSG00000029659.9 831.7908262 0.974760969 0.254179894 3.834925549 0.000125602 0.00760291 9.273338331 10.27907135 4 6430571L13Rik ENSMUSG00000037977.4 85.05977872 -1.23640166 0.379136907 -3.261095495 0.001109827 0.045866259 7.742929292 6.736008168 4 9130208D14Rik ENSMUSG00000086513.1 376.5962505 3.290961923 0.341319733 9.641874188 5.32E-22 1.93E-19 6.704735252 9.695259665 4 A430110N23Rik ENSMUSG00000035279.7 1751.48811 0.678734028 0.209130494 3.245504833 0.001172426 0.047443301 10.46787368 11.1615986 4 A530016L24Rik ENSMUSG00000043122.6 1117.618562 -1.42442697 0.363594946 -3.917620374 8.94E-05 0.005643978 10.6675755 8.908033892 4 A730085A09Rik ENSMUSG00000085843.1 20.38768786 1.57435754 0.378649319 4.157824826 3.21E-05 0.002242922 6.043255297 6.923716446 4 Abca8b ENSMUSG00000020620.8 379.8972836 1.725889462 0.238849596 7.22584207 4.98E-13 8.58E-11 7.977983126 9.462808934 4 Abca9 ENSMUSG00000041797.7 367.5597675 1.108315817 0.259301318 4.27423904 1.92E-05 0.001407982 8.282883158 9.274613287 4 Abcd2 ENSMUSG00000055782.7 334.2980854 -1.118704927 0.239131703 -4.678195789 2.89E-06 0.000248024 9.163210435 8.199976879 4 Acox2 ENSMUSG00000021751.7 91.80027617 -1.207682763 0.370267908 -3.26164579 0.001107675 0.045866259 7.688688496 6.475431196 4 Adamtsl1 ENSMUSG00000066113.8 62.55322526 1.246777302 0.379690108 3.283670751 0.001024646 0.043111894 6.508192888 7.592450096 4 Adar ENSMUSG00000027951.10 2600.561581 1.39365568 0.251717791 5.536579962 3.08E-08 3.33E-06 10.42221869 11.97051561 4 Add3 ENSMUSG00000025026.8 4010.203575 -1.208756304 0.239896888 -5.038649368 4.69E-07 4.44E-05 12.51082597 11.18785413 4 Adh1 ENSMUSG00000074207.4 649.4964171 -1.254380404 0.349378476 -3.590319637 0.000330273 0.016911416 10.04131363 8.519099709 4 Adhfe1 ENSMUSG00000025911.8 1188.321911 -1.324329508 0.363398746 -3.644287507 0.000268134 0.01438537 10.71371813 9.093503104 4 Adipor2 ENSMUSG00000030168.7 6482.966684 -0.924207457 0.267623131 -3.453391539 0.000553585 0.025535474 13.07437854 12.05759834 4 Agpat9 ENSMUSG00000029314.8 1767.697049 -1.242259875 0.360284674 -3.447995338 0.000564764 0.025904363 11.22624841 9.705769377 4 Agtr2 ENSMUSG00000068122.3 732.7740899 2.403607624 0.222636332 10.79611583 3.59E-27 2.02E-24 8.217311402 10.41779 4 Aldh1a7 ENSMUSG00000024747.3 2059.466077 -1.048418557 0.313871138 -3.340283419 0.000836929 0.036243936 11.49842969 10.27984141 4 Aldh4a1 ENSMUSG00000028737.9 3281.15586 -1.054328671 0.325266025 -3.241434976 0.001189296 0.047815557 12.12906272 10.87294328 4 Angptl1 ENSMUSG00000033544.6 87.76431967 -1.353162338 0.363995454 -3.717525379 0.000201184 0.01145411 7.835854764 6.835649204 4 Anxa8 ENSMUSG00000021950.9 1866.124258 -1.578359005 0.344337965 -4.583749593 4.57E-06 0.000381366 11.50993545 9.496234902 4 Apod ENSMUSG00000022548.8 7544.890724 1.990459138 0.270627001 7.354990923 1.91E-13 3.57E-11 11.29530224 13.62864277 4 Apol9a ENSMUSG00000068246.4 367.90769 3.769030717 0.28576939 13.18906381 1.01E-39 1.10E-36 6.776036767 9.652555523 4 Apol9b ENSMUSG00000057346.4 366.8489413 3.750034906 0.290217183 12.92147784 3.41E-38 2.77E-35 6.765658829 9.650096806 4 AW112010 ENSMUSG00000075010.3 46.31226495 1.347778791 0.362408836 3.718945721 0.000200056 0.011429868 6.546039549 7.362966053 4 B2m ENSMUSG00000060802.8 21268.31379 1.440040918 0.254008167 5.669270158 1.43E-08 1.58E-06 13.31013532 14.97636712 4 Baiap2l1 ENSMUSG00000038859.7 142.070731 -1.206288545 0.347220491 -3.474128335 0.000512516 0.024189262 8.27176608 7.245094205 4 BC006779 ENSMUSG00000027580.10 2339.912789 1.990003526 0.21496037 9.257536752 2.09E-20 6.81E-18 9.883902617 11.94393337 4 BC023105 ENSMUSG00000063388.3 28.4017035 1.990691608 0.379681494 5.243056724 1.58E-07 1.60E-05 6.012186479 7.133066497 4 Bcar3 ENSMUSG00000028121.4 697.1420554 -1.261487841 0.345597807 -3.650161589 0.000262075 0.014130376 10.07823466 8.656562795 4 Bche ENSMUSG00000027792.5 64.81521003 3.09400529 0.372936389 8.296335199 1.07E-16 2.69E-14 5.873365749 7.780546233 4 Bhlhe40 ENSMUSG00000030103.5 2254.067535 -1.144944005 0.338108976 -3.386316503 0.000708376 0.031688164 11.57920101 10.27151006 4 Bnip3 ENSMUSG00000078566.2 4816.230741 -1.295204693 0.356122809 -3.63696079 0.000275874 0.014584594 12.62100275 11.03827973 4 Bst2 ENSMUSG00000046718.7 3115.378766 2.964032922 0.278474979 10.64380336 1.86E-26 9.89E-24 9.175119247 12.51226356 4 C130026I21Rik ENSMUSG00000052477.9 235.3757405 1.230238436 0.345019243 3.56570963 0.000362873 0.018349878 7.590914151 8.84641387 4 C920025E04Rik ENSMUSG00000073405.5 1491.737494 1.509685344 0.239785832 6.295973918 3.05E-10 4.08E-08 9.643210679 11.21404207 4 Ccdc85a ENSMUSG00000032878.10 111.8007253 2.962757694 0.351732727 8.423321077 3.66E-17 9.93E-15 6.319496695 8.263612536 4 Ccl2 ENSMUSG00000035385.5 452.6575572 1.910302038 0.325142919 5.875268781 4.22E-09 4.95E-07 7.776534777 9.771734356 4 Ccl5 ENSMUSG00000035042.2 58.56441452 1.569170525 0.350960709 4.471071788 7.78E-06 0.000618187 6.603285988 7.555982454 4 Ccl7 ENSMUSG00000035373.2 540.9458472 2.166399595 0.288214907 7.51661189 5.62E-14 1.08E-11 7.91589847 10.01174755 4 Cd36 ENSMUSG00000002944.8 8381.364298 -1.360281471 0.360989493 -3.768202388 0.000164427 0.00963083 13.49203941 11.59113778 4 Cd74 ENSMUSG00000024610.8 121.2794614 2.550413792 0.328284445 7.768914524 7.92E-15 1.67E-12 6.608111661 8.311765048 4 Cdsn ENSMUSG00000039518.7 2688.87164 1.268892866 0.296617798 4.27787164 1.89E-05 0.001396554 10.48789687 11.95713927 4 Cela1 ENSMUSG00000023031.7 435.1737885 -1.028450431 0.297146746 -3.461085958 0.000538001 0.024958035 9.440745179 8.46779572 4 Ces1a ENSMUSG00000071047.4 85.93675871 1.214840113 0.322504388 3.766894835 0.000165291 0.00964669 6.985805197 7.801972687 4 Ces1f ENSMUSG00000031725.8 1050.495893 -1.967651671 0.298711061 -6.587140314 4.48E-11 6.52E-09 10.80774309 8.735908554 4 Cfh ENSMUSG00000026365.9 2456.079438 2.232684887 0.366052966 6.099349252 1.07E-09 1.30E-07 8.634942366 12.1683815 4 Cfhr2 ENSMUSG00000033898.10 222.6678561 1.837817374 0.376241352 4.884676723 1.04E-06 9.42E-05 6.826034703 8.983039333 4 Cfhr3 ENSMUSG00000090623.1 20.73437593 1.658594744 0.378552508 4.381412644 1.18E-05 0.000905644 6.012186479 6.939584556 4 Chdh ENSMUSG00000015970.11 14.8594517 -1.288242218 0.369615681 -3.485355967 0.000491483 0.023331818 6.755773987 5.97885233 4 Chn1 ENSMUSG00000056486.10 54.48190331 -1.357317687 0.372815582 -3.64072145 0.000271875 0.014498824 7.462699474 6.564829533 4 Chn2 ENSMUSG00000004633.9 52.09507088 -1.759952156 0.36631674 -4.804454631 1.55E-06 0.000138071 7.496814028 6.428138387 4 Chst1 ENSMUSG00000027221.5 624.4304653 -0.908355463 0.266740944 -3.405384451 0.00066071 0.029884266 9.8626978 8.981723782 4 Chst8 ENSMUSG00000060402.6 81.31501581 -1.085690251 0.327093406 -3.319205558 0.00090274 0.038784452 7.724831914 7.002216404 4 Cib2 ENSMUSG00000037493.6 956.6336722 -1.48646435 0.353089295 -4.209882231 2.56E-05 0.001824723 10.54773744 8.746332401 4 Cldn15 ENSMUSG00000001739.7 4995.524995 -0.954626482 0.273067117 -3.495940824 0.000472393 0.022557134 12.71400833 11.66071565 4 Clmn ENSMUSG00000021097.7 131.2530933 -1.633882716 0.306696454 -5.327360969 9.97E-08 1.03E-05 8.267668931 7.092216218 4 Cmpk2 ENSMUSG00000020638.7 327.577692 2.66957781 0.369482137 7.225187742 5.00E-13 8.58E-11 6.663944254 9.421113905 4 Cnnm2 ENSMUSG00000064105.5 1554.715793 -0.869778715 0.266128903 -3.268260995 0.001082105 0.045179283 11.06736782 10.13497016 4 Col11a1 ENSMUSG00000027966.10 3905.751101 0.887570822 0.220679951 4.021982135 5.77E-05 0.003789109 11.4063647 12.36826328 4 Col15a1 ENSMUSG00000028339.11 4239.977039 -1.297495902 0.314529394 -4.125197602 3.70E-05 0.002534241 12.55638909 11.06060668 4 Col1a1 ENSMUSG00000001506.9 220076.4026 0.817051048 0.24649978 3.31461168 0.000917705 0.039323665 17.18385776 18.1350187 4 Cpt2 ENSMUSG00000028607.9 2890.372821 -0.871596027 0.239494333 -3.639317956 0.000273361 0.014498824 11.93098262 10.99343247 4 Csmd1 ENSMUSG00000060924.7 26.4631684 2.259521055 0.379458811 5.954588453 2.61E-09 3.10E-07 5.738411976 7.120710373 4 Ctla2a ENSMUSG00000044258.9 2392.980655 0.72697606 0.193381088 3.75929243 0.000170395 0.009909053 10.86535263 11.61266261 4 Ctsc ENSMUSG00000030560.9 114.5956138 -1.128600473 0.327821024 -3.44273366 0.000575866 0.026265626 8.03096276 7.200797966 4 Cxcl10 ENSMUSG00000034855.7 118.9401029 3.473950436 0.351946401 9.870680397 5.58E-23 2.16E-20 6.170321956 8.34531439 4 Cyp51 ENSMUSG00000001467.4 5229.421241 -1.165546529 0.320244135 -3.639556213 0.000273108 0.014498824 12.83023314 11.42882562 4 D14Ertd668e ENSMUSG00000068245.7 395.5140432 3.315397615 0.274271112 12.08803069 1.22E-33 8.65E-31 7.062149507 9.711560421 4 Dach2 ENSMUSG00000025592.10 22.73260218 1.341103623 0.379270008 3.536012854 0.000406215 0.020043629 6.162297827 6.954584457 4 Dapk1 ENSMUSG00000021559.7 724.572609 -1.086921254 0.254307662 -4.274040528 1.92E-05 0.001407982 10.11709857 9.049556318 4 Dbi ENSMUSG00000026385.9 4125.496192 -0.992807541 0.305216751 -3.252795067 0.001142759 0.046870382 12.43783754 11.3070935 4 Ddx58 ENSMUSG00000040296.8 2708.691272 1.965275523 0.253845741 7.742007067 9.79E-15 2.02E-12 9.999519125 12.16046978 4 Ddx60 ENSMUSG00000037921.8 389.0655814 3.609995188 0.323675347 11.15313608 6.91E-29 4.33E-26 6.694091228 9.734857906 4 Dennd2d ENSMUSG00000027901.5 250.4271199 -1.371927148 0.377305879 -3.636113892 0.000276782 0.014585247 8.790209086 7.31893941 4 Dhx58 ENSMUSG00000017830.8 640.3183234 2.843148772 0.276196612 10.29393065 7.50E-25 3.13E-22 7.662347205 10.30970331 4 Disp2 ENSMUSG00000040035.7 693.9087941 -1.483808079 0.239110271 -6.205538869 5.45E-10 6.93E-08 10.17106972 8.753659408 4 Dmd ENSMUSG00000045103.10 136.4941088 2.535145342 0.325742436 7.782668328 7.10E-15 1.52E-12 6.673466561 8.430414489 4 Dpt ENSMUSG00000026574.4 5826.059821 1.444765588 0.284773195 5.073390377 3.91E-07 3.77E-05 11.38206013 13.14492862 4 Dtna ENSMUSG00000024302.8 302.4995991 1.261632809 0.363834257 3.467603126 0.000525122 0.024500186 7.636312452 9.189242785 4 Dtx3l ENSMUSG00000049502.10 1138.020506 1.770947304 0.245865149 7.202921256 5.89E-13 1.00E-10 9.110186912 10.89908248 4 Dysf ENSMUSG00000033788.9 1095.848914 -1.035769298 0.224069406 -4.622537796 3.79E-06 0.000321482 10.65531276 9.61175121 4 Ear2 ENSMUSG00000072596.4 832.6335756 -0.864755637 0.253069316 -3.417070272 0.000632989 0.028710212 10.22897143 9.359896263 4 Ecm1 ENSMUSG00000028108.8 5138.823702 1.461978454 0.23986483 6.095009659 1.09E-09 1.33E-07 11.32984752 12.93435701 4 Ecscr ENSMUSG00000073599.3 19.69050016 1.536585296 0.374538563 4.102609048 4.09E-05 0.002783216 5.972728911 6.901434425 Page 57 of 79 Diabetes
4 Eif2ak2 ENSMUSG00000024079.4 3044.092598 1.300121239 0.214656301 6.056757863 1.39E-09 1.68E-07 10.77321493 12.14725876 4 Emilin2 ENSMUSG00000024053.9 90.90993759 -1.252855364 0.365933567 -3.423723527 0.000617694 0.028094738 7.879464801 6.86667358 4 Emx2 ENSMUSG00000043969.3 176.1093923 1.119009262 0.29322313 3.816238036 0.000135502 0.008111675 7.56099162 8.461415154 4 Entpd5 ENSMUSG00000021236.10 1012.915252 -1.001743608 0.274163605 -3.653816875 0.000258371 0.014023494 10.5258329 9.490872012 4 Epas1 ENSMUSG00000024140.9 1129.781566 -1.253088929 0.256512706 -4.885094974 1.03E-06 9.42E-05 10.76872523 9.457059022 4 F830016B08Rik ENSMUSG00000090942.1 126.4114753 2.430247862 0.334888833 7.256879365 3.96E-13 6.94E-11 6.643040556 8.353776714 4 Fam107a ENSMUSG00000021750.9 1986.030096 -1.185492379 0.27006828 -4.389602429 1.14E-05 0.000880508 11.52698909 10.20108762 4 Fam171b ENSMUSG00000048388.3 345.4859275 1.215730485 0.290325829 4.187469259 2.82E-05 0.001997019 8.100445934 9.252390102 4 Ffar2 ENSMUSG00000051314.5 126.3054718 -1.219763862 0.377981623 -3.227045413 0.001250756 0.049794771 8.039829633 6.765810381 4 Fgfr2 ENSMUSG00000030849.10 4210.452533 -0.845131837 0.203298873 -4.157090623 3.22E-05 0.002242922 12.4503665 11.56062183 4 Fgfr3 ENSMUSG00000054252.9 509.1618086 -1.503162368 0.269717541 -5.573098295 2.50E-08 2.73E-06 9.77420919 8.363916303 4 Fhod3 ENSMUSG00000034295.8 68.34503893 2.129168413 0.344990775 6.171667667 6.76E-10 8.40E-08 6.47998642 7.75217431 4 Fibin ENSMUSG00000074971.3 312.2530828 1.088929565 0.250319528 4.350158265 1.36E-05 0.001035107 8.13913506 9.074993929 4 Folh1 ENSMUSG00000001773.7 341.2193041 0.762782123 0.23624269 3.228807305 0.001243076 0.049610319 8.414773572 9.079483063 4 Frk ENSMUSG00000019779.8 880.3899577 1.173957671 0.282974604 4.148632609 3.34E-05 0.002297944 9.150388191 10.4310281 4 Gap43 ENSMUSG00000047261.9 32.03335423 1.57407305 0.379109109 4.152031726 3.30E-05 0.002283338 6.110284724 7.195665213 4 Gbp1 ENSMUSG00000028269.4 52.30004243 1.273783699 0.367989329 3.461469118 0.000537236 0.024958035 6.602146513 7.433065035 4 Gbp10 ENSMUSG00000054588.7 1350.938307 2.639523519 0.259839599 10.15828044 3.04E-24 1.24E-21 8.582213273 11.29737765 4 Gbp11 ENSMUSG00000092021.1 148.2747898 2.428359682 0.302897686 8.017095525 1.08E-15 2.45E-13 6.825266337 8.500812735 4 Gbp2 ENSMUSG00000028270.6 655.8223577 1.866177536 0.24095884 7.744797971 9.57E-15 2.00E-12 8.433727908 10.18082232 4 Gbp3 ENSMUSG00000028268.8 800.4231325 3.487767565 0.266587027 13.08303563 4.12E-39 4.19E-36 7.476582942 10.65533763 4 Gbp4 ENSMUSG00000079363.2 308.4507691 3.464036477 0.267672931 12.94130288 2.63E-38 2.26E-35 6.864742061 9.420464412 4 Gbp6 ENSMUSG00000079362.2 1843.908018 2.664805471 0.252022543 10.573679 3.95E-26 1.84E-23 8.937985933 11.72995396 4 Gbp7 ENSMUSG00000040253.9 1201.508974 1.824343871 0.357031326 5.109758556 3.23E-07 3.18E-05 8.503210366 11.10141434 4 Gbp8 ENSMUSG00000034438.9 197.5899692 2.890107752 0.297997994 9.698413463 3.06E-22 1.13E-19 6.794209108 8.854758535 4 Gbp9 ENSMUSG00000029298.8 540.1249774 3.772641704 0.275132361 13.71209732 8.59E-43 1.27E-39 7.017914681 10.15130984 4 Gda ENSMUSG00000058624.6 2246.663844 -0.908418976 0.202247154 -4.491627987 7.07E-06 0.000570435 11.59185612 10.65538929 4 Gdf10 ENSMUSG00000021943.5 45.6731962 -2.313173811 0.376312054 -6.146956464 7.90E-10 9.74E-08 7.479548098 6.072071041 4 Gja1 ENSMUSG00000050953.8 1259.314465 0.978210021 0.2230089 4.386416966 1.15E-05 0.000889261 9.832061449 10.81866101 4 Gm10499 ENSMUSG00000073403.4 1057.832005 1.576043133 0.233977301 6.735880486 1.63E-11 2.50E-09 9.182116013 10.7592013 4 Gm11127 ENSMUSG00000079492.2 1858.993999 1.642051868 0.214996111 7.637588689 2.21E-14 4.45E-12 9.864104836 11.54351824 4 Gm12185 ENSMUSG00000048852.7 60.59592266 1.770245257 0.363682302 4.867559533 1.13E-06 0.000102207 6.489094588 7.615942334 4 Gm12222 ENSMUSG00000060068.6 250.6295441 -1.019945493 0.309665818 -3.293697377 0.000988789 0.041928255 8.797049871 7.905115288 4 Gm12250 ENSMUSG00000082292.2 299.4806407 3.696945235 0.29109881 12.69996684 5.92E-37 4.59E-34 6.690427599 9.39251816 4 Gm12505 ENSMUSG00000087070.1 28.16795192 -1.228172632 0.379295655 -3.238035068 0.00120356 0.048269876 7.031785985 6.269163275 4 Gm14446 ENSMUSG00000079339.6 70.51711226 3.039381782 0.362846627 8.376491765 5.45E-17 1.42E-14 6.099597615 7.847641951 4 Gm14506 ENSMUSG00000081597.1 160.6534575 -1.209092539 0.364257819 -3.319331737 0.000902332 0.038784452 8.333996137 7.288667884 4 Gm15433 ENSMUSG00000073632.3 205.4506106 2.917264093 0.306418402 9.520525126 1.72E-21 5.97E-19 6.771441675 8.911202238 4 Gm15753 ENSMUSG00000082088.1 21.84068213 1.222796208 0.378653859 3.229324564 0.00124083 0.049610319 6.179952591 6.922367436 4 Gm16026 ENSMUSG00000079455.2 71.40233357 1.590751591 0.332757124 4.780518516 1.75E-06 0.000153063 6.72600049 7.713208436 4 Gm16332 ENSMUSG00000089991.1 278.7458909 2.547052086 0.356675403 7.141092608 9.26E-13 1.54E-10 6.81751237 9.272498429 4 Gm16340 ENSMUSG00000090222.1 699.8124396 1.828569421 0.294250139 6.214336633 5.15E-10 6.61E-08 8.380849172 10.29642773 4 Gm16439 ENSMUSG00000072594.3 528.9407284 -1.228179736 0.360971803 -3.402425688 0.000667905 0.030042817 9.641437635 8.334746534 4 Gm16854 ENSMUSG00000085607.1 2678.112273 -1.432966896 0.360273519 -3.977441638 6.97E-05 0.004483341 11.83289644 10.04242752 4 Gm17782 ENSMUSG00000092366.1 739.1924907 1.577829384 0.234369084 6.732241964 1.67E-11 2.54E-09 8.763524569 10.2814693 4 Gm1966 ENSMUSG00000073902.3 34.32510012 1.691453441 0.379651108 4.455283825 8.38E-06 0.000662246 6.110284724 7.250425079 4 Gm2619 ENSMUSG00000091199.1 103.5668547 2.044124811 0.34808476 5.872491545 4.29E-09 4.99E-07 6.655843992 8.127472338 4 Gm2635 ENSMUSG00000089763.1 126.6786285 2.784658001 0.337745989 8.244829237 1.65E-16 4.02E-14 6.496378923 8.383639403 4 Gm2666 ENSMUSG00000090189.3 141.6067334 2.861782706 0.338235973 8.460905809 2.65E-17 7.32E-15 6.501927743 8.511500972 4 Gm4070 ENSMUSG00000078606.1 1849.029018 3.845549321 0.295458165 13.01554592 9.98E-39 9.03E-36 7.777718724 11.84259008 4 Gm4788 ENSMUSG00000070594.4 253.1675461 2.602931707 0.356246812 7.30654034 2.74E-13 4.96E-11 6.737856562 9.173451582 4 Gm4902 ENSMUSG00000091649.1 118.0730373 2.935977552 0.333224182 8.810817783 1.24E-18 3.68E-16 6.443421939 8.313167186 4 Gm4951 ENSMUSG00000073555.1 476.7258129 2.397998876 0.342143002 7.008762019 2.40E-12 3.92E-10 7.376710204 9.913397755 4 Gm4992 ENSMUSG00000084110.3 37.49685041 1.46899261 0.371764803 3.951403144 7.77E-05 0.004961163 6.387234222 7.243426386 4 Gm5514 ENSMUSG00000045104.8 330.2424783 -1.423055114 0.316168968 -4.500932284 6.77E-06 0.00055359 9.214745671 7.899791272 4 Gm5834 ENSMUSG00000085867.1 41.46438421 2.383636443 0.373133295 6.388163364 1.68E-10 2.33E-08 6.098878695 7.40187488 4 Gm6904 ENSMUSG00000090881.1 29.28925588 2.189424959 0.379683453 5.76644819 8.10E-09 9.03E-07 5.873365749 7.176095441 4 Gm6907 ENSMUSG00000091144.1 128.8540865 1.406908942 0.315939399 4.453097479 8.46E-06 0.000665796 7.163361476 8.211144861 4 Gm7582 ENSMUSG00000061852.8 160.1271712 2.349088317 0.334711997 7.01823758 2.25E-12 3.70E-10 6.78472938 8.599633675 4 Gm7592 ENSMUSG00000090186.3 664.3499693 2.762502906 0.315321635 8.760905055 1.94E-18 5.63E-16 7.561579243 10.37731842 4 Gm7609 ENSMUSG00000079457.3 319.9706297 2.970758039 0.288175515 10.30884958 6.43E-25 2.75E-22 7.047828825 9.439920457 4 Gm7676 ENSMUSG00000068631.6 383.5788286 1.034127454 0.318674174 3.245093383 0.001174121 0.047443301 8.244582074 9.347095223 4 Gm8810 ENSMUSG00000091373.2 416.6385399 1.656635283 0.259355941 6.387496966 1.69E-10 2.33E-08 8.080232385 9.561257328 4 Gm8815 ENSMUSG00000092224.1 847.9572258 1.585145123 0.229961004 6.893104029 5.46E-12 8.71E-10 8.921398757 10.46401363 4 Gm8835 ENSMUSG00000092457.1 144.9186073 1.350425405 0.31055142 4.34847602 1.37E-05 0.001038225 7.27785673 8.316184128 4 Gm8979 ENSMUSG00000091928.1 184.8423814 3.355572372 0.315375574 10.63992473 1.94E-26 9.89E-24 6.523291861 8.819781088 4 Gm8989 ENSMUSG00000091567.1 184.8423814 3.355572372 0.315375574 10.63992473 1.94E-26 9.89E-24 6.523291861 8.819781088 4 Gm9574 ENSMUSG00000073980.3 892.2548031 1.578927024 0.248489729 6.354093701 2.10E-10 2.82E-08 8.960983959 10.52746614 4 Gpc4 ENSMUSG00000031119.4 5093.38507 0.880734749 0.222968098 3.950048262 7.81E-05 0.004969841 11.77808217 12.74275601 4 Gpr149 ENSMUSG00000043441.5 307.7873671 1.213615546 0.349795618 3.469498997 0.00052143 0.02439783 7.794641648 9.164063037 4 Gpr56 ENSMUSG00000031785.8 315.4752375 -1.257804265 0.340441803 -3.694623437 0.000220213 0.012196349 9.117203189 7.886092723 4 Grhl1 ENSMUSG00000020656.9 160.4716877 -1.187525773 0.308265925 -3.852277134 0.000117024 0.007190602 8.380609687 7.434803683 4 Gria3 ENSMUSG00000001986.9 59.04955161 1.742255071 0.363391132 4.794434754 1.63E-06 0.000144365 6.486003862 7.598983002 4 Gsdmd ENSMUSG00000022575.4 148.8549176 1.99697456 0.310119272 6.439375877 1.20E-10 1.68E-08 6.99636444 8.454361762 4 Gvin1 ENSMUSG00000045868.5 1810.142264 3.844320749 0.294697405 13.04497657 6.79E-39 6.50E-36 7.765273972 11.81250128 4 H2-Bl ENSMUSG00000073406.2 794.5972489 1.545957481 0.228439705 6.767464005 1.31E-11 2.05E-09 8.877106887 10.36637246 4 H2-D1 ENSMUSG00000073411.4 12753.51068 1.714160528 0.203701682 8.415053372 3.93E-17 1.05E-14 12.455345 14.28969335 4 H2-K1 ENSMUSG00000061232.8 6682.477421 1.663364186 0.226471701 7.344688904 2.06E-13 3.82E-11 11.54538089 13.36384027 4 H2-K2 ENSMUSG00000067203.6 1246.782905 1.693113373 0.210820849 8.031052807 9.66E-16 2.22E-13 9.330219315 11.00483361 4 H2-Q10 ENSMUSG00000067235.7 1376.51034 1.704904047 0.215882959 7.897353516 2.85E-15 6.19E-13 9.435835085 11.14421726 4 H2-Q4 ENSMUSG00000035929.10 1588.651347 1.956271553 0.218266716 8.962757078 3.17E-19 9.92E-17 9.422133157 11.39194762 4 H2-Q6 ENSMUSG00000073409.5 1715.251653 1.794916349 0.215037385 8.346996714 7.00E-17 1.78E-14 9.645771615 11.46557586 4 H2-Q7 ENSMUSG00000060550.8 1768.719899 1.694926161 0.210608596 8.047753955 8.43E-16 1.96E-13 9.766282876 11.48617974 4 H2-Q8 ENSMUSG00000055413.9 423.7641399 1.502318211 0.256471333 5.857645749 4.69E-09 5.42E-07 8.196415322 9.547030504 4 H2-T10 ENSMUSG00000079491.2 1345.781162 1.330762492 0.213845918 6.222996919 4.88E-10 6.30E-08 9.680811267 11.01886124 4 H2-T22 ENSMUSG00000056116.11 2470.571342 1.546068533 0.207925413 7.435688171 1.04E-13 1.97E-11 10.31789047 11.91634012 Diabetes Page 58 of 79
4 H2-T23 ENSMUSG00000067212.7 2185.39671 1.540498729 0.228411411 6.744403547 1.54E-11 2.38E-09 10.1294903 11.74885183 4 H2-T24 ENSMUSG00000053835.10 416.3627732 1.394162839 0.278894711 4.998885893 5.77E-07 5.40E-05 8.204552212 9.508825304 4 H2-T3 ENSMUSG00000054128.10 297.2558339 1.611758532 0.258763741 6.228687701 4.70E-10 6.13E-08 7.79554314 9.144158995 4 H2afj ENSMUSG00000060032.4 1858.720617 -0.66307272 0.197816556 -3.351957655 0.000802423 0.035029095 11.23825679 10.56171597 4 Herc6 ENSMUSG00000029798.8 723.5168776 2.308888198 0.269559532 8.565411081 1.08E-17 3.02E-15 8.154317089 10.40473791 4 Hipk2 ENSMUSG00000061436.8 4138.364035 -1.231100004 0.276746767 -4.448471135 8.65E-06 0.000677026 12.53642963 11.17295043 4 Hmcn1 ENSMUSG00000066842.11 103.9270471 1.299916296 0.371069687 3.50315949 0.000459774 0.022149412 6.88091443 8.005806475 4 Hmga1 ENSMUSG00000046711.9 2900.851117 1.003225931 0.240545407 4.170630162 3.04E-05 0.002131939 10.90875455 11.97644266 4 Hp ENSMUSG00000031722.9 2479.256374 -1.311540057 0.346528208 -3.784800279 0.000153832 0.009075535 11.75277166 10.17955572 4 Hr ENSMUSG00000022096.8 86.25146069 -1.362597047 0.333964822 -4.080061601 4.50E-05 0.003054675 7.830403193 6.911814305 4 Hs6st2 ENSMUSG00000062184.5 381.0401886 1.645203957 0.311124363 5.287930331 1.24E-07 1.27E-05 7.867376191 9.484888446 4 Hsd11b1 ENSMUSG00000016194.8 1700.193524 -1.525142256 0.363346657 -4.197485311 2.70E-05 0.001919084 11.24454322 9.304460369 4 I830012O16Rik ENSMUSG00000062488.8 1579.751871 4.328624648 0.32694042 13.23979654 5.17E-40 6.01E-37 7.08337216 11.57287831 4 Ifi202b ENSMUSG00000026535.8 3106.847706 1.233585574 0.227060028 5.432861016 5.55E-08 5.83E-06 10.83601602 12.15789552 4 Ifi203 ENSMUSG00000039997.10 3561.762773 1.93859795 0.256671703 7.552830835 4.26E-14 8.46E-12 10.37266356 12.54391252 4 Ifi205 ENSMUSG00000054203.6 1250.092579 1.12217671 0.22112026 5.074961067 3.88E-07 3.76E-05 9.722351472 10.86047271 4 Ifi27l2a ENSMUSG00000079017.3 369.8475848 3.700911924 0.278234361 13.30141941 2.27E-40 2.84E-37 6.833903053 9.653064241 4 Ifi35 ENSMUSG00000010358.7 856.1837158 1.377700658 0.238874367 5.767469621 8.05E-09 9.03E-07 9.059317927 10.43111289 4 Ifi44 ENSMUSG00000028037.7 1275.525516 4.540520705 0.274219545 16.5579762 1.40E-61 1.14E-57 7.166820703 11.34333842 4 Ifi47 ENSMUSG00000078920.2 326.5090844 2.137934864 0.367179601 5.822586159 5.79E-09 6.60E-07 7.02413278 9.447140937 4 Ifih1 ENSMUSG00000026896.7 362.3604631 2.081712252 0.276983083 7.515665679 5.66E-14 1.08E-11 7.656751726 9.479727099 4 Ifit1 ENSMUSG00000034459.8 1786.54398 4.746175306 0.287291241 16.52043165 2.62E-61 1.42E-57 7.224879282 11.78122728 4 Ifit2 ENSMUSG00000045932.6 512.2148431 1.8659603 0.350400828 5.325216589 1.01E-07 1.04E-05 7.75089747 9.937773881 4 Ifit3 ENSMUSG00000074896.3 1973.127061 4.445173256 0.323021074 13.76124844 4.36E-43 7.10E-40 7.198917478 11.8830389 4 Ifitm3 ENSMUSG00000025492.6 8084.90901 1.087421949 0.298425213 3.643867548 0.000268572 0.01438537 12.10088045 13.51415735 4 Igfbp5 ENSMUSG00000026185.8 421.2216306 1.182424397 0.30314023 3.900585535 9.60E-05 0.006009699 8.284583602 9.49522577 4 Igsf10 ENSMUSG00000036334.7 405.6941499 0.978992754 0.231746772 4.224407294 2.40E-05 0.001722468 8.482434246 9.354766691 4 Igsf8 ENSMUSG00000038034.9 867.0719505 -0.797216217 0.208403226 -3.825354501 0.000130584 0.007846125 10.25844222 9.484536464 4 Igtp ENSMUSG00000078853.2 932.4830676 2.883785955 0.329433005 8.753785781 2.06E-18 5.89E-16 7.651960529 10.85065892 4 Iigp1 ENSMUSG00000054072.5 1013.659588 2.333917565 0.349781608 6.672499379 2.51E-11 3.76E-09 7.966805544 10.92147073 4 Il13ra1 ENSMUSG00000017057.8 467.2859919 1.358554063 0.277779833 4.890758437 1.00E-06 9.24E-05 8.337443053 9.653690214 4 Inhbb ENSMUSG00000037035.5 124.1009862 -1.102796628 0.308233048 -3.577801394 0.000346497 0.017631261 8.102229092 7.292497208 4 Insig1 ENSMUSG00000045294.9 3847.293301 -1.471918025 0.32772123 -4.491372215 7.08E-06 0.000570435 12.47650339 10.68354998 4 Irf1 ENSMUSG00000018899.9 1549.035244 0.73860898 0.199173943 3.70836149 0.000208605 0.011753324 10.27121013 11.01655245 4 Irf7 ENSMUSG00000025498.7 645.8533105 3.07865501 0.290773632 10.5878067 3.39E-26 1.67E-23 7.477316509 10.32074731 4 Irf9 ENSMUSG00000002325.8 1139.07639 2.271675349 0.218919957 10.37673945 3.16E-25 1.43E-22 8.788134645 10.99181997 4 Irgm1 ENSMUSG00000046879.5 1335.181309 2.429120108 0.297479767 8.165664949 3.20E-16 7.65E-14 8.590166788 11.25402217 4 Irgm2 ENSMUSG00000069874.5 1370.29308 2.974652664 0.305599232 9.733835542 2.16E-22 8.19E-20 8.107661906 11.37167003 4 Irx1 ENSMUSG00000060969.7 645.0052964 0.725574977 0.223428782 3.247455269 0.00116442 0.047400613 9.159141364 9.848317365 4 Isg15 ENSMUSG00000035692.6 1219.419756 3.856224873 0.276176407 13.96290479 2.63E-44 5.34E-41 7.538879694 11.2488156 4 Itga7 ENSMUSG00000025348.7 371.9901251 -1.323693008 0.36962923 -3.581137256 0.000342102 0.017462209 9.247891498 7.814313488 4 Itgbl1 ENSMUSG00000032925.9 2400.188749 1.1502543 0.314150857 3.661471152 0.000250771 0.013703575 10.31922673 11.82791654 4 Itpka ENSMUSG00000027296.7 60.53290951 -1.388145771 0.3706254 -3.74541456 0.000180096 0.010398955 7.554005579 6.60206554 4 Kank1 ENSMUSG00000032702.9 600.4503281 -1.296207135 0.354859732 -3.652730973 0.000259466 0.014036164 9.8564647 8.432180961 4 Kcnc2 ENSMUSG00000035681.6 99.75679558 1.247269587 0.319274346 3.906576285 9.36E-05 0.005885336 7.066396756 7.938802788 4 Kcnj2 ENSMUSG00000041695.2 25.68258252 1.488089686 0.372824311 3.991396602 6.57E-05 0.004244263 6.003797729 7.0178364 4 Kcnt2 ENSMUSG00000052726.9 105.0167246 2.102734141 0.335366311 6.269962344 3.61E-10 4.78E-08 6.689959067 8.138970606 4 Lcn2 ENSMUSG00000026822.9 1052.058619 -1.694607024 0.29229866 -5.797518957 6.73E-09 7.61E-07 10.77136342 8.967741707 4 Ldhb ENSMUSG00000030246.5 3031.059079 -1.560567821 0.292567493 -5.334043802 9.60E-08 1.00E-05 12.1932818 10.41746234 4 Lef1 ENSMUSG00000027985.8 723.3648742 -0.891415704 0.26527539 -3.360340746 0.000778464 0.034166385 10.04789927 9.165964928 4 Lgals3bp ENSMUSG00000033880.5 9053.311021 1.793677191 0.187853983 9.548252121 1.32E-21 4.67E-19 11.92605863 13.81649101 4 Lgals9 ENSMUSG00000001123.9 3000.318671 1.686036426 0.270346736 6.236570309 4.47E-10 5.87E-08 10.32267476 12.25298433 4 Lims2 ENSMUSG00000024395.7 183.3529172 -1.016569147 0.312990099 -3.247927492 0.001162489 0.047400613 8.491750827 7.605172422 4 Lipa ENSMUSG00000024781.8 4379.946322 0.637095291 0.190281871 3.348166004 0.000813483 0.035416948 11.75982294 12.42608758 4 Lpl ENSMUSG00000015568.8 84411.43608 -1.10498336 0.326790117 -3.381324292 0.000721374 0.031955145 16.76400289 15.44621315 4 Lrrc8d ENSMUSG00000046079.10 1280.475783 -1.091480998 0.310264464 -3.517905292 0.000434968 0.021079098 10.8390712 9.664573149 4 Ly6a ENSMUSG00000075602.4 1296.532913 1.339303745 0.25666647 5.218070538 1.81E-07 1.82E-05 9.580762568 10.96279285 4 Ly6c1 ENSMUSG00000079018.3 485.0259088 1.184069972 0.293725412 4.031213935 5.55E-05 0.003672909 8.487069411 9.621290786 4 Ly6c2 ENSMUSG00000022584.8 177.7856908 1.116497825 0.319252947 3.497220103 0.000470134 0.022515259 7.545956697 8.451748423 4 Ly6e ENSMUSG00000022587.7 4315.955022 0.863647051 0.215223306 4.012795215 6.00E-05 0.003923874 11.57286797 12.49374091 4 Mctp1 ENSMUSG00000021596.9 36.03387754 1.604324765 0.375790835 4.269196093 1.96E-05 0.001432457 6.294836682 7.239512665 4 Mgst3 ENSMUSG00000026688.5 3628.477586 -1.044486928 0.256537834 -4.071473244 4.67E-05 0.003156384 12.30872828 11.16026204 4 Mid2 ENSMUSG00000000266.5 359.5599201 1.924547199 0.264482784 7.276644505 3.42E-13 6.06E-11 7.767591724 9.442431352 4 Mmp9 ENSMUSG00000017737.2 640.6899927 1.583820631 0.326066622 4.85735283 1.19E-06 0.000107023 8.336870476 10.15592189 4 Mndal ENSMUSG00000090272.1 1881.397024 1.201914446 0.236420957 5.083789791 3.70E-07 3.61E-05 10.17032209 11.45501455 4 Mpeg1 ENSMUSG00000046805.9 40.63266071 1.348353089 0.378643325 3.561011111 0.000369429 0.018508984 6.386421055 7.280686971 4 Ms4a4d ENSMUSG00000024678.6 33.32457467 1.390117211 0.379663179 3.661448593 0.000250793 0.013703575 6.241054758 7.187458647 4 Mtap1b ENSMUSG00000052727.4 582.6613506 1.679270853 0.233297341 7.19798539 6.11E-13 1.03E-10 8.438500628 9.99395906 4 Mtap9 ENSMUSG00000033900.7 605.9832343 -0.717645109 0.218019694 -3.29165267 0.000996005 0.042015429 9.766710618 9.091942885 4 Mum1l1 ENSMUSG00000042515.6 1403.161381 1.03509641 0.291774618 3.547588943 0.000388774 0.019300044 9.808050547 11.01676436 4 Mx1 ENSMUSG00000000386.8 685.866 4.876505849 0.299776265 16.26715128 1.69E-59 4.58E-56 6.555900913 10.48784995 4 Mx2 ENSMUSG00000023341.8 587.8203827 4.688369549 0.286487437 16.36500922 3.40E-60 1.38E-56 6.614153471 10.29664969 4 Myo7a ENSMUSG00000030761.9 458.2324898 0.994680664 0.283905551 3.503561868 0.00045908 0.022149412 8.548993563 9.51318442 4 Naip1 ENSMUSG00000021640.5 103.0910216 1.129641463 0.310895375 3.633510027 0.000279592 0.014685773 7.151100898 7.938802788 4 Naip2 ENSMUSG00000078945.3 488.3061014 0.949190976 0.247287181 3.838415612 0.000123831 0.007551821 8.685120348 9.579054658 4 Naip3 ENSMUSG00000082956.3 94.07031058 1.037148473 0.317583129 3.265754308 0.001091729 0.045464521 7.121023066 7.839937963 4 Naip5 ENSMUSG00000071203.5 198.8491109 1.128868694 0.313434989 3.601603953 0.00031626 0.016348128 7.61384205 8.607924437 4 Nckap5 ENSMUSG00000049690.8 117.8547857 1.281514403 0.359637958 3.563345791 0.000366158 0.018401691 7.032283654 8.120042889 4 Ndn ENSMUSG00000033585.4 2708.692577 1.576158963 0.239586485 6.578663904 4.75E-11 6.84E-09 10.35885886 12.06762491 4 Ndrg2 ENSMUSG00000004558.8 94.44460855 -1.301800693 0.366588911 -3.551118581 0.000383598 0.019101281 7.919088496 6.860993394 4 Nfkbie ENSMUSG00000023947.7 263.5619939 1.330500511 0.281655288 4.723861288 2.31E-06 0.000200427 7.805475588 8.953693895 4 Ngf ENSMUSG00000027859.4 56.97376954 1.231257321 0.349731444 3.520579412 0.000430605 0.020929975 6.717617967 7.479566045 4 Nhsl1 ENSMUSG00000039835.9 124.7340112 1.66541754 0.304338353 5.472256531 4.44E-08 4.73E-06 7.048053538 8.225443854 4 Nmi ENSMUSG00000026946.3 215.6742671 1.065507738 0.279973259 3.805748237 0.000141376 0.008401561 7.782165786 8.650655229 4 Nov ENSMUSG00000037362.8 77.62300913 1.552149264 0.367362155 4.225120206 2.39E-05 0.001722468 6.633545493 7.820484184 4 Npnt ENSMUSG00000040998.12 205.8219816 -1.353774797 0.358973796 -3.771235704 0.000162441 0.009548842 8.630322103 7.40224606 Page 59 of 79 Diabetes
4 Npy1r ENSMUSG00000036437.5 323.8572595 2.17501414 0.281708821 7.720788185 1.16E-14 2.35E-12 7.496549953 9.364123106 4 Nup107 ENSMUSG00000052798.6 3587.887829 1.398537572 0.214932923 6.506855974 7.67E-11 1.10E-08 10.92705036 12.40110379 4 Oas1a ENSMUSG00000052776.9 255.0517103 4.600986698 0.333925264 13.77849236 3.43E-43 6.21E-40 6.122567821 9.224864882 4 Oas1b ENSMUSG00000029605.8 179.3377386 2.756934299 0.329178607 8.375192793 5.51E-17 1.42E-14 6.683260388 8.759640046 4 Oas1g ENSMUSG00000066861.7 166.4996627 4.177512709 0.351894708 11.87148489 1.66E-32 1.13E-29 6.001812744 8.721956892 4 Oas2 ENSMUSG00000032690.9 354.0772934 5.05325061 0.309496563 16.32732383 6.31E-60 2.05E-56 6.196497203 9.653732586 4 Oasl2 ENSMUSG00000029561.10 2132.84963 5.030440508 0.262744917 19.14571961 1.05E-81 1.71E-77 7.309405948 12.05998173 4 Obfc2a ENSMUSG00000026107.5 2639.020884 -0.93431069 0.2438511 -3.831480325 0.000127375 0.00768163 11.82864727 10.81796489 4 Ogn ENSMUSG00000021390.5 3031.87543 1.519668308 0.245611265 6.187290751 6.12E-10 7.67E-08 10.56158811 12.19357694 4 Olr1 ENSMUSG00000030162.7 378.2246263 -1.621986428 0.361127559 -4.491450147 7.07E-06 0.000570435 9.366567812 7.669757509 4 Ostn ENSMUSG00000052276.8 67.57158283 1.559523066 0.339513077 4.593410889 4.36E-06 0.000365998 6.694502095 7.668172475 4 Paqr4 ENSMUSG00000023909.3 2004.950995 -0.999448427 0.305066856 -3.276161951 0.001052282 0.044047064 11.43378044 10.32207048 4 Parm1 ENSMUSG00000034981.9 1797.089514 -1.29478076 0.323378643 -4.003915492 6.23E-05 0.004041728 11.36431114 9.872515349 4 Parp10 ENSMUSG00000063268.6 1228.572801 0.921780013 0.204047558 4.517476322 6.26E-06 0.000517262 9.849512446 10.76701776 4 Parp12 ENSMUSG00000038507.6 1902.489641 1.359116579 0.233207701 5.827923226 5.61E-09 6.44E-07 10.08385835 11.50375927 4 Parp14 ENSMUSG00000034422.8 1886.528237 2.738136215 0.295448302 9.26773381 1.90E-20 6.32E-18 8.703822385 11.78741025 4 Parp9 ENSMUSG00000022906.8 1485.731991 1.660082942 0.227575473 7.294647883 2.99E-13 5.36E-11 9.551214356 11.2357248 4 Pcx ENSMUSG00000024892.8 25642.27809 -1.288964475 0.334698921 -3.851116308 0.000117581 0.007197615 15.13566989 13.47609075 4 Pdgfrl ENSMUSG00000031595.9 877.1212829 1.03374522 0.316725536 3.263851833 0.001099086 0.045654137 9.146504325 10.40839874 4 Pdzd2 ENSMUSG00000022197.8 984.0693493 -1.723564782 0.261563908 -6.589459512 4.41E-11 6.48E-09 10.69629808 8.940248892 4 Pdzk1 ENSMUSG00000038298.8 135.7436626 -1.2257055 0.376372843 -3.25662577 0.00112745 0.046359251 8.151121099 6.708085653 4 Peg10 ENSMUSG00000092035.1 16877.83344 -1.862002915 0.362406318 -5.13788756 2.78E-07 2.76E-05 14.51760275 11.97506756 4 Peli2 ENSMUSG00000021846.7 4115.113839 -0.724731986 0.190532035 -3.803727743 0.000142535 0.008439617 12.37271732 11.61576917 4 Pex11a ENSMUSG00000030545.7 1265.937117 -1.100809873 0.333061495 -3.305124999 0.000949341 0.04046626 10.80098754 9.576729701 4 Pgm5 ENSMUSG00000041731.7 164.80551 1.155057654 0.354656819 3.256831931 0.001126631 0.046359251 7.32154972 8.454845604 4 Phactr1 ENSMUSG00000054728.9 340.2435133 0.992996233 0.283567776 3.501795039 0.000462135 0.022197475 8.230473649 9.165753771 4 Phf11 ENSMUSG00000044703.5 84.70254979 2.322759974 0.346017904 6.712831747 1.91E-11 2.88E-09 6.478423564 7.964073609 4 Pkia ENSMUSG00000027499.7 335.198908 1.179171895 0.25914913 4.55016729 5.36E-06 0.000445317 8.144294905 9.191216719 4 Pla1a ENSMUSG00000002847.6 47.30966603 1.648336429 0.364989523 4.516119841 6.30E-06 0.000517956 6.443421939 7.413413122 4 Pla2g16 ENSMUSG00000060675.7 2285.805769 -1.198630551 0.309740232 -3.869792896 0.000108928 0.006744 11.67467228 10.32072368 4 Plac8 ENSMUSG00000029322.6 2961.615188 1.264583659 0.349438508 3.618901841 0.000295856 0.015342103 10.24216815 12.20359977 4 Plin1 ENSMUSG00000030546.7 4462.967901 -1.184622371 0.359357801 -3.29649828 0.000978982 0.0416208 12.52739216 10.97011893 4 Plscr2 ENSMUSG00000032372.7 52.49352624 1.253012604 0.363497762 3.447098539 0.000566642 0.025917499 6.622806842 7.442444456 4 Pml ENSMUSG00000036986.9 1521.907046 1.033328803 0.263383781 3.923281837 8.74E-05 0.005534374 9.974785447 11.11614559 4 Pnpla2 ENSMUSG00000025509.8 14361.55201 -1.104855489 0.340471795 -3.245072 0.001174209 0.047443301 14.25454405 12.78700362 4 Podn ENSMUSG00000028600.8 204.1451928 -1.412192348 0.31493675 -4.484050683 7.32E-06 0.000587465 8.671273251 7.501352937 4 Ppargc1b ENSMUSG00000033871.8 328.7106404 -1.36217779 0.352746851 -3.861629905 0.000112633 0.006946988 9.160074382 7.807069224 4 Ppef1 ENSMUSG00000062168.6 322.500779 2.866039593 0.277759156 10.31843427 5.82E-25 2.56E-22 7.145174458 9.42274282 4 Ppp1r1b ENSMUSG00000061718.6 18.25356405 -1.581353451 0.374383752 -4.223883766 2.40E-05 0.001722468 6.885561407 5.871291545 4 Prkd1 ENSMUSG00000002688.7 68.18478894 3.044316749 0.367637581 8.280755037 1.22E-16 3.02E-14 6.042396779 7.81726977 4 Psen2 ENSMUSG00000010609.9 1483.961307 -0.867931141 0.267111289 -3.249324066 0.001156796 0.047326912 10.99081045 10.08576133 4 Psmb10 ENSMUSG00000031897.8 977.2675629 0.960182599 0.21688418 4.427167536 9.55E-06 0.000743865 9.526856258 10.47288255 4 Psmb8 ENSMUSG00000024338.8 130.4268731 1.885545507 0.318152981 5.926537291 3.09E-09 3.65E-07 6.944075723 8.314339959 4 Ptchd1 ENSMUSG00000041552.7 46.32526627 1.313670329 0.372570428 3.525965111 0.000421943 0.020570331 6.501927743 7.372420196 4 Ptprq ENSMUSG00000035916.5 118.2008152 3.099777918 0.348699074 8.88955018 6.14E-19 1.89E-16 6.311594262 8.321057015 4 Pygo1 ENSMUSG00000034910.5 378.3833716 0.795612913 0.235419981 3.3795471 0.000726054 0.032038839 8.507895429 9.212162555 4 Rarres2 ENSMUSG00000009281.4 998.526422 -1.288337143 0.318251112 -4.048177977 5.16E-05 0.003444648 10.59288337 9.149196641 4 Rasd1 ENSMUSG00000049892.7 92.00175852 -1.344242505 0.37763047 -3.559677019 0.000371311 0.018546196 7.870747387 6.729137915 4 Rilpl2 ENSMUSG00000029401.7 935.2285429 -0.822788729 0.222555313 -3.697007802 0.000218156 0.012123646 10.36617655 9.556342473 4 Rnf125 ENSMUSG00000033107.4 204.0088498 -1.176161603 0.347872674 -3.38101176 0.000722195 0.031955145 8.601679769 7.548272201 4 Rnf130 ENSMUSG00000020376.10 50.60831061 1.200620118 0.362993757 3.307550323 0.000941158 0.040222771 6.637173325 7.393862947 4 Rnf157 ENSMUSG00000052949.8 312.3681217 0.978341118 0.289062251 3.38453435 0.000712991 0.031743879 8.144726312 9.064576834 4 Rnf213 ENSMUSG00000070327.6 16203.28213 2.655540391 0.194987062 13.61905943 3.09E-42 4.19E-39 11.97543499 14.80243831 4 Robo1 ENSMUSG00000022883.9 112.8361095 2.095506053 0.324276452 6.4620975 1.03E-10 1.46E-08 6.763917747 8.199512214 4 Robo2 ENSMUSG00000052516.11 150.7232618 1.505883918 0.374255334 4.023680574 5.73E-05 0.003777103 6.912065637 8.42430579 4 Rpia ENSMUSG00000053604.5 963.0549933 -0.747768686 0.223466802 -3.346218228 0.000819219 0.035571579 10.37761555 9.639489904 4 Rps6ka1 ENSMUSG00000003644.11 372.1782488 -1.159092469 0.319606977 -3.626618163 0.000287157 0.015034677 9.292159829 8.172238946 4 Rpusd3 ENSMUSG00000051169.8 523.0320934 -1.120364826 0.26039108 -4.302623683 1.69E-05 0.001254961 9.709392418 8.649899032 4 Rrad ENSMUSG00000031880.6 147.5309398 1.164775764 0.321565993 3.622198206 0.00029211 0.015244967 7.372744014 8.278311558 4 Rsad2 ENSMUSG00000020641.8 117.2155113 3.340958696 0.366695036 9.111000616 8.16E-20 2.61E-17 6.073465597 8.301825083 4 Rspo3 ENSMUSG00000019880.9 69.78510018 1.405476469 0.378861703 3.709734863 0.000207476 0.011730342 6.532816186 7.687262633 4 Rtp4 ENSMUSG00000033355.5 605.4536986 3.836165322 0.268075536 14.31001642 1.89E-46 4.41E-43 7.083798322 10.29791907 4 S100a8 ENSMUSG00000056054.8 70.54950589 -1.380955821 0.369332245 -3.739061078 0.000184709 0.010627612 7.658504278 6.688292937 4 Samd9l ENSMUSG00000047735.10 3795.126691 1.697524239 0.256869709 6.608502993 3.88E-11 5.75E-09 10.66410612 12.58418916 4 Samsn1 ENSMUSG00000022876.10 19.67134651 1.316610782 0.379228047 3.471818061 0.000516947 0.024257754 6.14798092 6.874520312 4 Scarb1 ENSMUSG00000037936.9 2264.925046 -1.247343565 0.250680192 -4.975836156 6.50E-07 6.01E-05 11.70569676 10.38146253 4 Scp2 ENSMUSG00000028603.9 7031.759083 -0.922376842 0.21666446 -4.257167244 2.07E-05 0.001504967 13.204889 12.21818111 4 Scp2-ps2 ENSMUSG00000058492.4 1027.336721 -0.932884406 0.230671623 -4.044209668 5.25E-05 0.003489209 10.52868791 9.598464211 4 Scpep1 ENSMUSG00000000278.9 7422.220861 0.777393524 0.223488817 3.478444845 0.000504332 0.023872213 12.38196703 13.23765272 4 Sema3g ENSMUSG00000021904.5 1575.361164 -1.216829032 0.329037326 -3.698148924 0.000217177 0.012110619 11.13829388 9.76655653 4 Sema6a ENSMUSG00000019647.9 111.7487978 2.680546894 0.338029061 7.929930298 2.19E-15 4.89E-13 6.486003862 8.25098425 4 Serpina3n ENSMUSG00000021091.8 556.6546524 -1.062958679 0.23744922 -4.476572624 7.59E-06 0.000605431 9.777440516 8.771747499 4 Serpinf1 ENSMUSG00000000753.8 13527.3685 0.883733092 0.227515799 3.884271311 0.000102637 0.006403227 13.15103559 14.14055924 4 Sh2d3c ENSMUSG00000059013.6 130.7913233 -1.211569574 0.350663387 -3.455078633 0.000550132 0.02544831 8.168402826 7.192950575 4 Sh3tc1 ENSMUSG00000036553.9 227.0720149 -1.15217676 0.320655459 -3.593192407 0.000326651 0.01683184 8.743165288 7.706401772 4 Shisa5 ENSMUSG00000025647.10 4662.834408 0.734787962 0.19562212 3.756159888 0.00017254 0.009998138 11.78153332 12.55314107 4 Siglec1 ENSMUSG00000027322.4 453.5367933 -1.439480027 0.363972394 -3.954915398 7.66E-05 0.00490809 9.56247082 7.933204731 4 Slc13a4 ENSMUSG00000029843.4 237.620075 -1.339525706 0.379425192 -3.530407931 0.000414919 0.020288686 8.711244842 7.205101364 4 Slc1a3 ENSMUSG00000005360.8 3423.476724 -1.804971451 0.283181229 -6.373909235 1.84E-10 2.50E-08 12.414357 10.39898956 4 Slc22a15 ENSMUSG00000033147.8 405.4539754 0.83110635 0.235372018 3.531032942 0.00041394 0.020288686 8.561536722 9.308019896 4 Slc25a10 ENSMUSG00000025792.3 4196.70986 -1.095276074 0.309224854 -3.542005311 0.000397097 0.019653308 12.49332827 11.23411911 4 Slc38a1 ENSMUSG00000023169.8 103.8352984 1.545700819 0.322752468 4.78912161 1.68E-06 0.000147439 6.95496619 8.035562704 4 Slc43a1 ENSMUSG00000027075.10 269.8909002 -1.402994682 0.345653091 -4.058967561 4.93E-05 0.003302846 8.95669038 7.643360335 4 Slc5a6 ENSMUSG00000006641.6 2087.151631 -1.159563252 0.331812398 -3.494635099 0.00047471 0.022601484 11.53975361 10.13633131 4 Slc6a14 ENSMUSG00000031089.7 36.51929542 1.302337523 0.377439392 3.450454693 0.000559643 0.025742001 6.378419242 7.221856355 4 Slfn10-ps ENSMUSG00000072621.5 86.79209416 1.968549554 0.346463477 5.681838596 1.33E-08 1.48E-06 6.631910063 7.933076362 Diabetes Page 60 of 79
4 Slfn2 ENSMUSG00000072620.3 217.8957804 2.165092897 0.315432154 6.863894097 6.70E-12 1.06E-09 7.140743111 8.878856254 4 Slfn8 ENSMUSG00000035208.9 237.6829832 3.256866731 0.292327979 11.1411393 7.91E-29 4.77E-26 6.752492368 9.093163633 4 Slfn9 ENSMUSG00000069793.5 564.5746693 1.458629077 0.290605001 5.019284148 5.19E-07 4.88E-05 8.452730969 9.905520638 4 Sod3 ENSMUSG00000072941.4 2829.598899 0.882643206 0.202725533 4.353882776 1.34E-05 0.001022444 10.98494359 11.90612456 4 Sorbs2 ENSMUSG00000031626.9 39.97885933 1.941875407 0.373854955 5.194194647 2.06E-07 2.05E-05 6.221910301 7.347255158 4 Sorbs3 ENSMUSG00000022091.5 1283.714289 0.783451667 0.221697653 3.533874421 0.000409516 0.020145446 9.986137877 10.77555327 4 Sort1 ENSMUSG00000068747.7 2775.882048 -1.194486892 0.32156124 -3.714648229 0.000203487 0.011544849 11.963636 10.5172023 4 Sp100 ENSMUSG00000026222.9 512.2702149 2.820406045 0.317933313 8.871061729 7.25E-19 2.18E-16 7.312489197 10.04169511 4 Sp110 ENSMUSG00000070034.7 128.1648038 1.75288611 0.315873473 5.549329902 2.87E-08 3.11E-06 6.998867381 8.274513522 4 Sp140 ENSMUSG00000070031.5 536.5263381 0.830223329 0.24647466 3.36839222 0.00075608 0.033273629 8.860291897 9.659720352 4 Spry4 ENSMUSG00000024427.6 1332.168471 -1.230073474 0.317756769 -3.87111651 0.000108338 0.006733082 10.93188404 9.577970934 4 Srpx2 ENSMUSG00000031253.9 2661.429075 1.146576279 0.301050281 3.80858731 0.000139763 0.00833612 10.51381548 11.9593958 4 Stat1 ENSMUSG00000026104.7 7528.955001 1.034982022 0.282841182 3.659233833 0.00025297 0.013776313 12.10042201 13.37854282 4 Stat2 ENSMUSG00000040033.8 2758.635887 2.208684797 0.217879133 10.13720206 3.78E-24 1.50E-21 9.918223857 12.20821158 4 Stxbp2 ENSMUSG00000004626.8 174.2875214 -1.022771432 0.304884893 -3.354614986 0.000794755 0.034787629 8.411809504 7.596936129 4 Syt13 ENSMUSG00000027220.2 196.7410207 1.464318104 0.287506347 5.093167916 3.52E-07 3.45E-05 7.492231329 8.646652304 4 Tap1 ENSMUSG00000037321.9 1594.525788 1.68580959 0.282436356 5.968812277 2.39E-09 2.86E-07 9.480199017 11.36701101 4 Tap2 ENSMUSG00000024339.6 1003.381763 0.960557506 0.259098485 3.707306533 0.000209475 0.011761679 9.503078747 10.52760932 4 Tapbp ENSMUSG00000024308.7 6982.872475 0.885197979 0.230675987 3.837408436 0.00012434 0.007554557 12.22246616 13.181794 4 Tbc1d4 ENSMUSG00000033083.9 1788.813124 -0.87770623 0.262967405 -3.337699705 0.00084475 0.036485578 11.25185407 10.32877175 4 Tcf7l2 ENSMUSG00000024985.11 761.071343 -1.508743772 0.216048361 -6.983361347 2.88E-12 4.65E-10 10.29815211 8.868226397 4 Tcirg1 ENSMUSG00000001750.9 1395.449594 0.760039857 0.211627517 3.591403753 0.000328902 0.016894339 10.11459031 10.88150808 4 Tes ENSMUSG00000029552.12 615.4211839 0.920632502 0.251212122 3.664761459 0.000247569 0.013618816 8.965202348 9.857516321 4 Tgtp1 ENSMUSG00000078922.3 485.6939303 3.603523963 0.340768022 10.57471281 3.90E-26 1.84E-23 6.705629779 9.955810326 4 Tgtp2 ENSMUSG00000078921.3 541.0412562 3.326101953 0.35172134 9.456639608 3.18E-21 1.08E-18 6.790323213 10.09207325 4 Thbs1 ENSMUSG00000040152.8 5419.082591 1.381431459 0.319904285 4.318264949 1.57E-05 0.001180034 11.20525094 13.02090438 4 Timp4 ENSMUSG00000030317.6 333.8849139 -2.055881284 0.26030708 -7.89790766 2.84E-15 6.19E-13 9.368542083 7.641744394 4 Tlr3 ENSMUSG00000031639.5 700.9960916 1.25756184 0.259801469 4.840472405 1.30E-06 0.000115887 8.877399384 10.139949 4 Tmem106a ENSMUSG00000034947.7 692.07527 0.803906123 0.225069125 3.571818759 0.000354511 0.01798286 9.196479702 9.966499778 4 Tor3a ENSMUSG00000060519.5 2554.04385 1.262660765 0.203720407 6.198008255 5.72E-10 7.22E-08 10.57930362 11.88438425 4 Tpm1 ENSMUSG00000032366.9 5180.031636 0.859778057 0.261958535 3.282115073 0.001030315 0.04323873 11.75851376 12.77453613 4 Trem2 ENSMUSG00000023992.8 224.5689097 -1.213301426 0.358505607 -3.384330406 0.000713521 0.031743879 8.742326768 7.527494574 4 Treml1 ENSMUSG00000023993.6 186.7984562 -1.489370462 0.358929683 -4.149476997 3.33E-05 0.002297944 8.573661703 7.238058463 4 Trim12c ENSMUSG00000057143.7 834.4643303 1.284499095 0.315884588 4.066355705 4.78E-05 0.003213136 8.89911708 10.41974573 4 Trim21 ENSMUSG00000030966.6 348.1556843 0.981373467 0.289242091 3.392913748 0.000691534 0.031019971 8.248616535 9.195083945 4 Trim25 ENSMUSG00000000275.9 3916.669695 1.059128004 0.194518469 5.444871185 5.18E-08 5.48E-06 11.3166522 12.42266381 4 Trim29 ENSMUSG00000032013.5 192.6178355 -1.25575488 0.368997656 -3.403151377 0.000666134 0.030042817 8.562053051 7.322193362 4 Trim30a ENSMUSG00000030921.9 1871.487271 2.181899026 0.28935787 7.540486198 4.68E-14 9.19E-12 9.212066411 11.70336573 4 Trim30d ENSMUSG00000057596.7 601.3270562 1.942689333 0.351918852 5.520276399 3.38E-08 3.63E-06 7.80273505 10.17994217 4 Trim34a ENSMUSG00000056144.7 182.9997898 1.362612797 0.371700014 3.66589385 0.000246476 0.013604648 7.126388744 8.651274974 4 Trim34b ENSMUSG00000090215.1 88.67230197 1.398780373 0.375768638 3.722451085 0.000197298 0.011311992 6.670198482 7.941929107 4 Trim5 ENSMUSG00000060441.7 302.0852818 1.278889751 0.30617913 4.176933125 2.95E-05 0.002082714 7.900443393 9.120061703 4 Tspan7 ENSMUSG00000058254.6 171.8879076 1.581596134 0.316805037 4.992332659 5.97E-07 5.55E-05 7.263604074 8.548607304 4 Uba7 ENSMUSG00000032596.7 422.1892322 1.250940856 0.289141172 4.32640169 1.52E-05 0.001142561 8.275827888 9.509247111 4 Ube2l6 ENSMUSG00000027078.7 851.8895939 1.337302597 0.282464576 4.734408175 2.20E-06 0.000191299 8.995920183 10.43277193 4 Usp18 ENSMUSG00000030107.9 659.4277377 2.548495883 0.348395346 7.31495387 2.57E-13 4.71E-11 7.472798354 10.30977131 4 Usp46 ENSMUSG00000054814.8 1547.716597 -0.693102386 0.21051964 -3.292340733 0.000993572 0.042015429 10.99737709 10.29376013 4 Vcam1 ENSMUSG00000027962.9 3713.522774 0.937209715 0.199317517 4.702094066 2.58E-06 0.000221851 11.32339356 12.30809152 4 Vstm2a ENSMUSG00000048834.8 601.0497639 -1.416059725 0.280829528 -5.042417502 4.60E-07 4.38E-05 9.963390705 8.578991067 4 Wnk4 ENSMUSG00000035112.10 1073.767577 -0.994380759 0.268338181 -3.705699853 0.000210808 0.011795821 10.60811441 9.571215227 4 Xaf1 ENSMUSG00000040483.9 659.5912928 3.320715681 0.265725213 12.49680316 7.77E-36 5.75E-33 7.428473292 10.38836761 4 Xpnpep2 ENSMUSG00000037005.9 800.7164262 0.754089083 0.232547345 3.242733575 0.001183889 0.047715986 9.392568763 10.14486313 4 Yeats4 ENSMUSG00000020171.6 2407.262075 1.06242278 0.202157594 5.255418603 1.48E-07 1.50E-05 10.64370474 11.73946847 4 Zbp1 ENSMUSG00000027514.8 300.2672184 3.601710145 0.324074739 11.11382563 1.07E-28 6.25E-26 6.603020362 9.36682944 4 Zc3hav1 ENSMUSG00000029826.8 3468.159759 0.953330117 0.205335842 4.642784756 3.44E-06 0.000293047 11.21671685 12.21443971 6 1100001G20Rik ENSMUSG00000051748.2 284.7925868 -1.830046785 0.369680794 -4.950343151 7.41E-07 5.15E-05 9.003343751 7.405160615 6 1110018G07Rik ENSMUSG00000042350.7 1342.27452 -0.857074405 0.280346798 -3.05719349 0.0022342 0.039753787 10.81795031 9.958819167 6 1110021L09Rik ENSMUSG00000037455.9 1175.626424 -1.226524355 0.293646482 -4.176873998 2.96E-05 0.00125552 10.75021035 9.519442726 6 1190005I06Rik ENSMUSG00000043687.8 263.3109933 -1.493174359 0.425439905 -3.509718628 0.000448581 0.01171311 8.756619961 7.431785693 6 1300001I01Rik ENSMUSG00000020741.10 7554.259909 -1.266134662 0.360380342 -3.513328879 0.000442529 0.011592627 13.31817939 11.95138503 6 1300015D01Rik ENSMUSG00000087382.1 102.5171404 -1.725960167 0.455845068 -3.786286807 0.000152915 0.004926332 7.781957321 6.487652909 6 1500003O03Rik ENSMUSG00000014077.7 10320.74414 -0.956059396 0.256913366 -3.721329927 0.000198176 0.006096989 13.74651386 12.74181153 6 1700008I05Rik ENSMUSG00000058252.6 38.36998458 1.552954815 0.44804651 3.466057165 0.000528151 0.013154551 6.111585338 7.002682872 6 1700018A04Rik ENSMUSG00000038408.7 24.53796083 -1.715994061 0.466337119 -3.679728653 0.000233482 0.006999346 6.733835949 5.86800924 6 1700023L04Rik ENSMUSG00000045709.10 55.19853218 -1.651942243 0.476306499 -3.468233679 0.000523892 0.013095691 7.239589305 6.101709283 6 1700040I03Rik ENSMUSG00000030008.3 381.0294319 -0.851170003 0.268884268 -3.165562672 0.001547833 0.030017165 9.161307109 8.393919641 6 2010002M12Rik ENSMUSG00000067297.4 237.1444728 3.229657322 0.333654234 9.679653351 3.68E-22 3.63E-19 6.553479004 9.013981419 6 2010003K11Rik ENSMUSG00000042041.6 91.73140213 -1.593274013 0.478412959 -3.330332057 0.000867425 0.019378788 7.625194938 6.332228254 6 2010016I18Rik ENSMUSG00000091575.1 16.42455368 -1.676326702 0.485038095 -3.456072255 0.000548108 0.01357686 6.499590116 5.683780111 6 2010107E04Rik ENSMUSG00000021290.5 1060.449833 -0.7914816 0.262604271 -3.013970784 0.002578526 0.044508079 10.48166733 9.69554047 6 2310001A20Rik ENSMUSG00000033096.7 5098.904856 -1.581713438 0.352596033 -4.485908207 7.26E-06 0.000382817 12.87553065 11.116082 6 2400009B08Rik ENSMUSG00000089665.1 231.0584395 -1.961619371 0.303315018 -6.46726754 9.98E-11 1.64E-08 8.823893708 7.227945383 6 2410066E13Rik ENSMUSG00000038065.6 301.5093348 -0.901044743 0.275976384 -3.264934229 0.001094895 0.023226504 8.891769652 8.100223939 6 2610019F03Rik ENSMUSG00000050052.5 164.6028871 -1.127028504 0.363163431 -3.103364511 0.001913338 0.035173677 8.231730132 7.330890957 6 3110039M20Rik ENSMUSG00000089922.1 23.49807464 1.776433235 0.48596889 3.655446409 0.000256735 0.007477687 5.584895762 6.745660861 6 3110043O21Rik ENSMUSG00000028300.8 1992.525842 -1.393722711 0.363597722 -3.833144785 0.000126515 0.004242536 11.45759823 10.00153799 6 3830417A13Rik ENSMUSG00000031179.8 26.77754101 -1.965572846 0.477999415 -4.112082114 3.92E-05 0.00161147 6.788513121 5.767287866 6 3930402G23Rik ENSMUSG00000038917.3 105.7896197 -2.076018793 0.420228977 -4.940208564 7.80E-07 5.38E-05 7.965327732 6.418423069 6 4430402I18Rik ENSMUSG00000064202.7 72.86128618 -1.367016846 0.39576914 -3.454076397 0.000552181 0.013657108 7.484947397 6.582417602 6 4632428C04Rik ENSMUSG00000086897.1 30.87048047 -1.911042017 0.470161553 -4.064649704 4.81E-05 0.00188713 6.879562408 5.863399425 6 4632428N05Rik ENSMUSG00000020101.7 966.5867886 -2.271316401 0.317977674 -7.143005897 9.13E-13 1.97E-10 10.71028518 8.440637185 6 4930528F23Rik ENSMUSG00000024155.7 31.17482137 1.749455398 0.474959869 3.68337519 0.000230166 0.006912568 5.849109064 6.916812551 6 4930568K20Rik ENSMUSG00000090220.1 32.35643595 -1.616641742 0.480452987 -3.364828166 0.000765913 0.017541129 6.846396654 5.917728787 6 5730469M10Rik ENSMUSG00000021792.9 2604.596382 -1.185076781 0.37377232 -3.170584647 0.001521325 0.029612816 11.7735949 10.50274635 6 5730508B09Rik ENSMUSG00000050549.7 422.9459405 -1.70610967 0.401503019 -4.249307205 2.14E-05 0.000958111 9.458146624 7.766851241 6 5830416P10Rik ENSMUSG00000074788.3 120.1241755 -1.208541204 0.401336752 -3.011289638 0.002601406 0.04476165 7.899680745 6.994974882 Page 61 of 79 Diabetes
6 6330406I15Rik ENSMUSG00000029659.9 733.1544516 1.184342016 0.270968161 4.370779249 1.24E-05 0.000602414 8.95148597 10.12633829 6 6430571L13Rik ENSMUSG00000037977.4 117.7312198 -1.661044363 0.428676268 -3.874822304 0.000106703 0.003683596 7.947775758 6.693959973 6 9130208D14Rik ENSMUSG00000086513.1 529.5130025 2.520946979 0.337529703 7.468815207 8.09E-14 2.09E-11 7.562606392 9.959635666 6 9530008L14Rik ENSMUSG00000058022.6 136.2341859 -1.667247535 0.435110871 -3.831776325 0.000127221 0.004257502 8.091556526 6.762544153 6 9630013D21Rik ENSMUSG00000059027.8 105.3190208 -1.509415801 0.448997774 -3.361744509 0.000774518 0.017688772 7.769532185 6.653282031 6 9930111J21Rik1 ENSMUSG00000069893.4 54.21281785 1.605736278 0.409118411 3.924869266 8.68E-05 0.003148157 6.306252574 7.288145105 6 9930111J21Rik2 ENSMUSG00000069892.3 135.7806879 1.119403398 0.315385182 3.549321473 0.000386225 0.010331683 7.203562377 8.046359402 6 A530016L24Rik ENSMUSG00000043122.6 1854.449699 -2.158719491 0.296356132 -7.284207274 3.24E-13 7.92E-11 11.61202235 9.360507714 6 A530020G20Rik ENSMUSG00000086471.1 197.147129 -1.932261007 0.367641547 -5.255828739 1.47E-07 1.27E-05 8.604909188 7.033045327 6 A830007P12Rik ENSMUSG00000059555.6 99.30113597 1.086162238 0.35062847 3.097758255 0.001949904 0.035574794 6.953786671 7.71677584 6 Abca1 ENSMUSG00000015243.4 7427.506735 -1.473979238 0.380370744 -3.875112011 0.000106576 0.003683596 13.30643937 11.71072941 6 Abca8b ENSMUSG00000020620.8 447.1950644 1.748631433 0.26279825 6.653892982 2.85E-11 4.98E-09 8.030542444 9.606766272 6 Abca9 ENSMUSG00000041797.7 461.2673527 1.033501494 0.308285851 3.352412999 0.000801104 0.018194607 8.472828681 9.459614795 6 Abcb1b ENSMUSG00000028970.5 306.9914377 1.228876458 0.27042355 4.544265683 5.51E-06 0.000306432 7.940100099 9.009019203 6 Abcb8 ENSMUSG00000028973.11 1512.153425 -1.085931521 0.333749935 -3.253728041 0.001139013 0.0240053 11.03302947 9.907092022 6 Abcd2 ENSMUSG00000055782.7 853.9514451 -2.244195775 0.331138231 -6.777217378 1.23E-11 2.36E-09 10.53273666 8.291288137 6 Abcg1 ENSMUSG00000024030.6 491.1383524 -1.774659469 0.416188762 -4.264073495 2.01E-05 0.000916887 9.579257704 7.855551766 6 Abhd11 ENSMUSG00000040532.8 636.0396488 -0.967605223 0.322381548 -3.001428678 0.00268716 0.04557391 9.831268344 8.897799865 6 Abhd15 ENSMUSG00000000686.11 656.9136533 -2.010518838 0.357480637 -5.624133535 1.86E-08 2.05E-06 10.13656552 8.110808093 6 Abhd3 ENSMUSG00000002475.9 97.10950503 -1.333017156 0.391746808 -3.402751797 0.000667109 0.015923122 7.731875253 6.792691816 6 Abhd5 ENSMUSG00000032540.8 4002.397062 -1.055107836 0.276577104 -3.814877732 0.00013625 0.004477422 12.42503408 11.31303856 6 Ablim2 ENSMUSG00000029095.11 87.70083709 -1.351607055 0.409854251 -3.297774886 0.000974542 0.021143591 7.658893987 6.669616777 6 Abtb1 ENSMUSG00000030083.8 514.8450319 -0.837302726 0.262336033 -3.191718329 0.001414292 0.028316919 9.53895933 8.757279725 6 Acad10 ENSMUSG00000029456.6 739.6892834 -0.94972655 0.294538237 -3.224459272 0.001262108 0.025917931 10.04095744 9.114416726 6 Acad11 ENSMUSG00000090150.1 1228.354565 -1.219846167 0.329821861 -3.698500042 0.000216877 0.006585841 10.78464618 9.545497442 6 Acad12 ENSMUSG00000042647.7 461.184785 -0.885950645 0.298160734 -2.971386047 0.002964589 0.049054819 9.404093844 8.579318814 6 Acadm ENSMUSG00000062908.6 4935.092026 -1.13100728 0.371625023 -3.043409919 0.002339135 0.041155718 12.66676408 11.43286115 6 Acads ENSMUSG00000029545.7 3660.564102 -1.364977132 0.334736821 -4.077762132 4.55E-05 0.0018098 12.35617153 10.88524168 6 Acadsb ENSMUSG00000030861.8 3811.563738 -0.906842689 0.273983176 -3.309848085 0.000933466 0.020505988 12.29946485 11.35904504 6 Acadvl ENSMUSG00000018574.8 2981.481146 -1.166341189 0.347007928 -3.36113701 0.000776223 0.017703069 11.98757036 10.75296413 6 Acat2 ENSMUSG00000023832.7 3802.621993 -0.899541264 0.280222325 -3.2100985 0.001326895 0.026895455 12.30619136 11.34186583 6 Acat3 ENSMUSG00000062480.5 1332.295124 -0.918100421 0.288899378 -3.177924531 0.001483334 0.029200124 10.84129166 9.887363592 6 Acbd4 ENSMUSG00000056938.9 1410.861154 -1.082435427 0.294488413 -3.675646917 0.000237247 0.007047797 10.95828282 9.858685521 6 Aco1 ENSMUSG00000028405.8 6313.26473 -1.152482886 0.321186993 -3.588199126 0.00033297 0.009161143 13.08167958 11.83611352 6 Acox1 ENSMUSG00000020777.10 7007.390787 -1.124742604 0.355818963 -3.160996805 0.001572302 0.030381762 13.17673843 11.9683903 6 Acox2 ENSMUSG00000021751.7 95.29643999 -1.803825422 0.481045787 -3.749799855 0.000176976 0.005570151 7.581417363 6.250204518 6 Acox3 ENSMUSG00000029098.9 1555.430883 -1.044434949 0.31607228 -3.304418056 0.000951738 0.020808798 11.06737162 9.997847657 6 Acsl1 ENSMUSG00000018796.6 54210.9478 -1.979379114 0.363462169 -5.445901341 5.15E-08 4.94E-06 16.37972722 14.02781299 6 Acsl5 ENSMUSG00000024981.4 1592.011427 0.737484922 0.228821136 3.222975526 0.001268664 0.025996332 10.28243882 11.03000013 6 Acss3 ENSMUSG00000035948.6 64.02654641 -1.217999459 0.393754202 -3.093298946 0.001979446 0.035985543 7.350138487 6.567626535 6 Acta2 ENSMUSG00000035783.8 7968.369766 1.02690518 0.338366083 3.034893956 0.002406203 0.042023884 12.19245881 13.41003972 6 Actg1 ENSMUSG00000062825.8 30944.02305 0.830593216 0.244295179 3.399957461 0.000673963 0.016040133 14.39498727 15.29789726 6 Adam12 ENSMUSG00000054555.5 4386.607698 -1.201631973 0.263011794 -4.568737976 4.91E-06 0.000277007 12.6101251 11.33973102 6 Adamdec1 ENSMUSG00000022057.7 36.2605316 1.472413489 0.442112299 3.330406081 0.000867194 0.019378788 6.121861625 6.964312596 6 Adamts14 ENSMUSG00000059901.6 657.2795689 0.876726762 0.277369088 3.16086687 0.001573004 0.030381762 9.025621758 9.865430136 6 Adamtsl3 ENSMUSG00000070469.4 175.1269825 1.346730673 0.352109051 3.824754491 0.000130902 0.004355471 7.253810464 8.392403891 6 Adar ENSMUSG00000027951.10 2359.821809 1.41349085 0.26627942 5.308299261 1.11E-07 1.00E-05 10.30573958 11.80915978 6 Adc ENSMUSG00000028789.10 922.6267782 -0.794432919 0.241116686 -3.294806892 0.000984893 0.021334586 10.30024179 9.520055459 6 Adck3 ENSMUSG00000026489.7 591.5135245 -1.379893021 0.407105535 -3.38952164 0.000700147 0.01643559 9.796249076 8.356299298 6 Adcy7 ENSMUSG00000031659.5 86.70801314 1.265398639 0.36467101 3.469973222 0.00052051 0.013050959 6.770080674 7.627576705 6 Adcyap1r1 ENSMUSG00000029778.6 184.7242923 -1.432287393 0.401099427 -3.570903613 0.000355752 0.009642344 8.456728326 7.169396062 6 Add3 ENSMUSG00000025026.8 2687.229001 -0.989404243 0.234869953 -4.212562021 2.52E-05 0.001098233 11.85587343 10.82572809 6 Adhfe1 ENSMUSG00000025911.8 2400.116688 -2.046083282 0.406901991 -5.028442542 4.94E-07 3.65E-05 11.83461671 9.456515971 6 Adig ENSMUSG00000044405.4 990.9903477 -1.888989504 0.356866634 -5.293264558 1.20E-07 1.07E-05 10.65324169 8.685040795 6 Adipoq ENSMUSG00000022878.5 31079.10001 -1.746306913 0.31513144 -5.541519151 3.00E-08 3.05E-06 15.55527971 13.59177015 6 Adipor2 ENSMUSG00000030168.7 6607.49712 -1.368869963 0.25528768 -5.362068245 8.23E-08 7.71E-06 13.24307774 11.79690317 6 Adrb3 ENSMUSG00000031489.7 531.9387369 -2.452524184 0.449121319 -5.460716465 4.74E-08 4.63E-06 9.766210196 7.143408313 6 Agpat2 ENSMUSG00000026922.7 5754.599389 -1.23215234 0.396091365 -3.110778087 0.001865951 0.034534837 12.89456358 11.48175473 6 Agpat9 ENSMUSG00000029314.8 2923.590987 -2.12560664 0.330608995 -6.429367241 1.28E-10 2.06E-08 12.22773683 9.911402303 6 Agrn ENSMUSG00000041936.10 5249.188995 0.965776876 0.285294318 3.385194915 0.000711277 0.016591074 11.72016082 12.80973818 6 Agt ENSMUSG00000031980.9 7156.174419 -1.145361455 0.263097287 -4.353376157 1.34E-05 0.000646548 13.29105417 12.07096942 6 Agtr2 ENSMUSG00000068122.3 639.2688218 2.185500866 0.386850335 5.649473894 1.61E-08 1.80E-06 7.831291168 10.15342922 6 Ahcyl2 ENSMUSG00000029772.9 2879.752813 -0.934018439 0.219217402 -4.260694782 2.04E-05 0.000928274 11.93074248 10.97230267 6 AI607873 ENSMUSG00000073490.3 953.0779617 1.04371515 0.320178534 3.259791146 0.001114943 0.023590751 9.305768591 10.44790714 6 Ak2 ENSMUSG00000028792.8 4357.195706 -1.305096328 0.324004995 -4.028012992 5.63E-05 0.00215512 12.59886738 11.18845079 6 Alad ENSMUSG00000028393.4 1647.498902 -1.037684909 0.327340932 -3.170043246 0.001524163 0.029612816 11.13744917 10.0675684 6 Aldh1a1 ENSMUSG00000053279.6 184.9283554 -1.411709414 0.32160305 -4.389602069 1.14E-05 0.000559198 8.44875545 7.317141017 6 Aldh1a7 ENSMUSG00000024747.3 1687.450797 -1.920940745 0.302018657 -6.360338006 2.01E-10 3.14E-08 11.45260766 9.408605445 6 Aldh1l2 ENSMUSG00000020256.8 2400.330828 1.145080932 0.253077428 4.524626871 6.05E-06 0.000325283 10.54655712 11.74829953 6 Aldh3b2 ENSMUSG00000075296.4 563.1465256 -1.765650692 0.440805878 -4.005506235 6.19E-05 0.002338219 9.683526702 7.885157274 6 Aldh4a1 ENSMUSG00000028737.9 2566.231884 -1.429722291 0.330150995 -4.330510323 1.49E-05 0.000711206 11.88237819 10.34621728 6 Aldh6a1 ENSMUSG00000021238.9 6130.86075 -1.642190324 0.405972899 -4.045073765 5.23E-05 0.002027717 13.04824628 11.16432162 6 Aldoa ENSMUSG00000030695.7 32750.88262 -1.175316854 0.383590986 -3.063984552 0.002184102 0.03914197 15.35018109 14.08418455 6 Aldoart1 ENSMUSG00000059343.3 822.6043693 -1.179814073 0.392257099 -3.007757098 0.002631834 0.044979115 10.15373966 8.974894504 6 Ampd3 ENSMUSG00000005686.9 420.4909144 1.047032257 0.268157677 3.904539562 9.44E-05 0.003365331 8.389017296 9.351712508 6 Angptl1 ENSMUSG00000033544.6 206.7111468 -2.20684129 0.344053141 -6.414245443 1.42E-10 2.25E-08 8.711451305 6.962143521 6 Angptl4 ENSMUSG00000002289.9 2608.861571 -1.072574401 0.276130451 -3.884303224 0.000102624 0.003572876 11.83351518 10.69889102 6 Ank2 ENSMUSG00000032826.8 567.8619004 0.784818001 0.264338226 2.968991711 0.002987787 0.049239924 8.89867712 9.65544773 6 Ankrd1 ENSMUSG00000024803.8 34.16908126 1.50882656 0.441446597 3.417914128 0.00063103 0.015284538 6.096562345 6.920828025 6 Ankrd5 ENSMUSG00000074771.3 152.8808759 -1.066652924 0.355839113 -2.997570773 0.002721407 0.046053277 8.140853962 7.306161961 6 Anxa3 ENSMUSG00000029484.8 708.1346195 1.3126915 0.317767947 4.130975168 3.61E-05 0.001495811 8.752916564 10.13207476 6 Anxa8 ENSMUSG00000021950.9 941.037976 -1.653560259 0.364925762 -4.531223694 5.86E-06 0.000320159 10.53664984 8.785363077 6 Aoc2 ENSMUSG00000078651.2 382.6623472 -1.30981879 0.370146465 -3.53865 0.000402179 0.010688698 9.241954974 8.037385764 6 Aoc3 ENSMUSG00000019326.8 8300.356808 -1.879854803 0.367960542 -5.108848875 3.24E-07 2.52E-05 13.60235684 11.49329624 6 Aox3 ENSMUSG00000064294.6 24.40903162 -1.423107241 0.462323671 -3.078162184 0.002082815 0.037697577 6.692708535 5.96569309 6 Ap3m2 ENSMUSG00000031539.4 865.6725254 0.896104328 0.263311812 3.403205958 0.000666001 0.015919938 9.353998974 10.25652589 Diabetes Page 62 of 79
6 Apex2 ENSMUSG00000025269.10 495.3470462 -1.131653635 0.335636438 -3.371665016 0.000747153 0.017207597 9.560505046 8.471634771 6 Apln ENSMUSG00000037010.7 1081.164247 -1.176063027 0.27660086 -4.251841548 2.12E-05 0.000951036 10.6428816 9.445608504 6 Apod ENSMUSG00000022548.8 7806.499183 1.626734465 0.219760763 7.402297134 1.34E-13 3.38E-11 11.85889459 13.55510714 6 Apoe ENSMUSG00000002985.9 792.1397928 -1.13689434 0.358299953 -3.173023967 0.001508601 0.029485142 10.17084348 8.988244712 6 Apol10b ENSMUSG00000050014.6 107.1226819 1.300211645 0.39505939 3.291180209 0.00099768 0.021544073 6.838756273 7.861912311 6 Apol6 ENSMUSG00000033576.5 343.6633725 -1.529640636 0.420549946 -3.637238929 0.000275576 0.007881258 9.074116325 7.677811585 6 Apol7a ENSMUSG00000010601.5 28.37294092 1.498333997 0.452444498 3.31164155 0.000927503 0.020438881 6.010120033 6.798152314 6 Apol9a ENSMUSG00000068246.4 465.0368188 3.097823513 0.28075632 11.03385138 2.62E-28 4.30E-25 7.201475311 9.85489116 6 Apol9b ENSMUSG00000057346.4 467.6337034 3.206440888 0.28973117 11.06695177 1.81E-28 3.31E-25 7.125259377 9.873965476 6 Aqp7 ENSMUSG00000028427.7 511.3852028 -1.641020894 0.417400584 -3.931525155 8.44E-05 0.003089583 9.641740216 7.967539986 6 Arhgef37 ENSMUSG00000045094.6 54.0898298 -2.11596647 0.473193057 -4.471676914 7.76E-06 0.00040273 7.281903443 5.928456476 6 Arhgef5 ENSMUSG00000033542.6 856.6436579 0.735727103 0.248290155 2.96317469 0.003044837 0.049915222 9.453853104 10.18155008 6 Arid3a ENSMUSG00000019564.6 341.3149476 -0.987985604 0.287028474 -3.442117053 0.00057718 0.014189812 9.064298436 8.183691073 6 Arl4a ENSMUSG00000047446.12 1203.419339 -1.430265065 0.307127932 -4.656903244 3.21E-06 0.000192109 10.83889082 9.379918361 6 Arl4c ENSMUSG00000049866.6 242.8831835 1.258475777 0.347052593 3.626181741 0.000287643 0.008146406 7.601874264 8.748682629 6 Armcx4 ENSMUSG00000049804.8 2322.146569 -0.847440066 0.220449448 -3.844146922 0.000120973 0.004081702 11.59730745 10.7315303 6 Arxes1 ENSMUSG00000048355.2 1858.729142 -1.237669217 0.403238705 -3.069321473 0.002145456 0.038575862 11.31077448 9.891462178 6 Arxes2 ENSMUSG00000048040.7 3179.981158 -1.190675176 0.383425079 -3.105365929 0.001900438 0.035086199 12.05583265 10.73623035 6 Ass1 ENSMUSG00000076441.4 978.1680349 0.783527119 0.248516992 3.15281105 0.001617064 0.031013593 9.601823576 10.37223978 6 Atp10a ENSMUSG00000025324.6 699.9906751 1.003180106 0.294848672 3.402355861 0.000668076 0.015923122 8.984290858 10.01505294 6 Atp10d ENSMUSG00000046808.10 763.2068827 -1.166699288 0.371046839 -3.144345042 0.00166459 0.031811465 10.07600806 8.937311475 6 Atp1a2 ENSMUSG00000007097.8 3400.443977 -1.975898825 0.360849783 -5.475682459 4.36E-08 4.29E-06 12.38121349 10.17268094 6 Atp1a4 ENSMUSG00000007107.5 105.8110472 -1.604611812 0.441592028 -3.633697414 0.000279388 0.007940056 7.84073081 6.604812149 6 Atp2b4 ENSMUSG00000026463.10 1774.454361 -0.858976016 0.220982729 -3.887073076 0.00010146 0.00354743 11.22474063 10.35606642 6 Atp5j2 ENSMUSG00000038690.9 2877.562484 -0.777688496 0.247392266 -3.143544092 0.001669153 0.031811465 11.86583072 11.06618191 6 Atp5k ENSMUSG00000050856.10 1227.55886 -0.977251604 0.237752504 -4.110373556 3.95E-05 0.001619383 10.75344163 9.778107911 6 Atpaf2 ENSMUSG00000042709.7 912.52937 -1.265217171 0.331054667 -3.821777183 0.000132493 0.004380295 10.39482566 9.129946762 6 AW112010 ENSMUSG00000075010.3 89.79792266 1.290586101 0.354863918 3.636847916 0.000275995 0.007881258 6.787515072 7.669816865 6 Axl ENSMUSG00000002602.9 8192.737322 0.800540398 0.251219243 3.186620537 0.001439455 0.028680659 12.51596493 13.36965683 6 B2m ENSMUSG00000060802.8 25309.32976 0.989043371 0.255614985 3.869269916 0.000109162 0.003744841 13.99141017 15.05879738 6 B3galt2 ENSMUSG00000033849.2 186.1486062 -2.092055084 0.45987006 -4.549230898 5.38E-06 0.000300308 8.444558908 6.581526067 6 B430010I23Rik ENSMUSG00000084960.1 31.50826711 -1.756448482 0.459541131 -3.822179046 0.000132278 0.004380295 6.885075032 5.953617205 6 B430219N15Rik ENSMUSG00000085211.1 35.36480036 -1.816106391 0.462903769 -3.923291428 8.73E-05 0.00316186 6.964285145 5.957831576 6 BC006779 ENSMUSG00000027580.10 2110.450673 1.590308908 0.237756712 6.688807636 2.25E-11 4.05E-09 10.05943534 11.68884212 6 BC013529 ENSMUSG00000040006.7 1569.001649 -0.958243163 0.307015672 -3.121153901 0.001801439 0.033568171 11.05154648 10.08356505 6 BC023105 ENSMUSG00000063388.3 44.97810536 1.74645174 0.467615337 3.73480423 0.000187861 0.00587891 5.994005497 7.190095803 6 BC046404 ENSMUSG00000046417.8 287.8077469 0.852506099 0.287837877 2.961757873 0.003058882 0.049959712 8.070395028 8.820132534 6 Bcar3 ENSMUSG00000028121.4 1052.046317 -1.921964693 0.316979663 -6.063369104 1.33E-09 1.85E-07 10.77823459 8.804779522 6 Bcat1 ENSMUSG00000030268.10 622.1196651 1.446506439 0.247208568 5.851360468 4.88E-09 6.20E-07 8.606951803 9.972668709 6 Bcat2 ENSMUSG00000030826.9 7775.871489 -1.851259261 0.42052931 -4.402212209 1.07E-05 0.00053407 13.41534619 11.17646508 6 Bche ENSMUSG00000027792.5 52.98439443 3.421882123 0.450779951 7.591025545 3.17E-14 8.97E-12 5.523068028 7.437145893 6 Bckdha ENSMUSG00000060376.6 2205.543322 -1.186595987 0.327393227 -3.624375485 0.000289661 0.008189402 11.59114392 10.34851036 6 Bckdhb ENSMUSG00000032263.7 2568.585241 -1.382870343 0.361612828 -3.824173907 0.000131211 0.004355471 11.82830925 10.34140377 6 Bcl2l13 ENSMUSG00000009112.2 3378.134813 -1.081172834 0.314196489 -3.441072297 0.000579414 0.014202131 12.17093453 11.02681878 6 Bcl6 ENSMUSG00000022508.5 690.6231951 -1.59644954 0.389729873 -4.09629759 4.20E-05 0.001703972 10.03444913 8.444613922 6 Bdnf ENSMUSG00000048482.7 318.4508741 1.0001752 0.286328423 3.493104845 0.000477439 0.012252027 8.094509875 8.991648966 6 Bnc1 ENSMUSG00000025105.7 69.72505712 1.363413767 0.4228371 3.22444215 0.001262184 0.025917931 6.530107742 7.425726945 6 Bnip3 ENSMUSG00000078566.2 3976.003933 -1.6789888 0.401294387 -4.183932932 2.87E-05 0.001226676 12.42023003 10.58016039 6 Brp44 ENSMUSG00000026568.5 2323.628091 -1.273407392 0.264103075 -4.821630321 1.42E-06 9.34E-05 11.73384359 10.40529988 6 Brp44l ENSMUSG00000023861.10 1297.399943 -1.064398896 0.32043667 -3.321713757 0.000894664 0.019905976 10.81697672 9.74273915 6 Bscl2 ENSMUSG00000071657.6 509.3958611 -1.456048968 0.383740238 -3.794360932 0.000148024 0.004795098 9.611964398 8.228448193 6 Bst2 ENSMUSG00000046718.7 3447.669069 2.884283987 0.29804822 9.677239431 3.77E-22 3.63E-19 9.503630343 12.60921883 6 C130026I21Rik ENSMUSG00000052477.9 255.2584691 1.492380908 0.329387642 4.530773822 5.88E-06 0.000320159 7.551589594 8.845239734 6 C2cd2l ENSMUSG00000032120.9 371.465534 -0.879479558 0.28352951 -3.101897785 0.001922843 0.035269336 9.13710077 8.340355328 6 C3 ENSMUSG00000024164.8 83731.35175 -1.124888507 0.280309251 -4.0130267 5.99E-05 0.002281471 16.80999907 15.60206964 6 C77080 ENSMUSG00000050390.6 751.2245518 1.067319386 0.306618607 3.480934816 0.000499667 0.012663896 9.043197885 10.09902857 6 C920025E04Rik ENSMUSG00000073405.5 1806.338631 1.038762128 0.241193621 4.30675623 1.66E-05 0.000778393 10.24608387 11.31340192 6 Cables1 ENSMUSG00000040957.8 191.472757 -1.537103037 0.383036003 -4.012946627 6.00E-05 0.002281471 8.474075646 7.21501733 6 Camk4 ENSMUSG00000038128.5 85.86881396 -1.214293106 0.365696481 -3.320494371 0.000898582 0.019966047 7.607119006 6.783715384 6 Camkk1 ENSMUSG00000020785.11 139.3095795 1.265702473 0.386617265 3.273786737 0.001061167 0.022628103 7.053272418 8.135600807 6 Camp ENSMUSG00000038357.7 354.5370507 -2.28608524 0.38327762 -5.964567511 2.45E-09 3.30E-07 9.327642396 7.275535272 6 Camsap3 ENSMUSG00000044433.8 216.808823 -1.064628831 0.358504485 -2.969638805 0.002981501 0.049185765 8.538647469 7.605674711 6 Car2 ENSMUSG00000027562.7 342.2084566 -1.483469017 0.452558304 -3.277962207 0.001045594 0.022412614 9.046372477 7.518715948 6 Car3 ENSMUSG00000027559.4 3258.703672 -1.603754907 0.421522998 -3.804667636 0.000141995 0.004629084 12.27848757 10.10238416 6 Car5b ENSMUSG00000031373.4 4986.912985 -1.271346599 0.334917912 -3.795994646 0.000147053 0.00477499 12.78024871 11.38091848 6 Cask ENSMUSG00000031012.10 3433.075577 0.780225565 0.222624381 3.504672584 0.000457169 0.011843064 11.3183353 12.12320687 6 Casp4 ENSMUSG00000033538.7 253.2514821 0.908156204 0.292503975 3.104765344 0.0019043 0.035086199 7.904982974 8.682322611 6 Cav1 ENSMUSG00000007655.9 35731.3399 -1.101997551 0.32542583 -3.386324774 0.000708355 0.016546628 15.53612791 14.35990694 6 Cav2 ENSMUSG00000000058.6 11217.67242 -1.456331557 0.329224517 -4.423520975 9.71E-06 0.000488445 13.97063435 12.40410947 6 Ccdc125 ENSMUSG00000048924.6 91.09098248 -1.824552255 0.445325167 -4.097123612 4.18E-05 0.001702119 7.707131684 6.417689363 6 Ccdc144b ENSMUSG00000047696.9 75.37696396 -1.412798566 0.46156192 -3.060907984 0.002206669 0.039374274 7.434075488 6.467114842 6 Ccdc85a ENSMUSG00000032878.10 54.78705074 3.062693913 0.435450095 7.033398197 2.02E-12 4.18E-10 5.788852658 7.434699394 6 Ccl2 ENSMUSG00000035385.5 877.3896775 1.901467673 0.380723686 4.994350865 5.90E-07 4.26E-05 8.376678012 10.58868698 6 Ccl5 ENSMUSG00000035042.2 42.52281965 1.493276909 0.423725511 3.524160976 0.000424826 0.011199836 6.216177009 7.077754157 6 Ccl7 ENSMUSG00000035373.2 728.5834662 2.028073261 0.324224768 6.255146008 3.97E-10 6.03E-08 8.255998333 10.33416273 6 Ccl8 ENSMUSG00000009185.2 30.77208416 1.625085665 0.447143804 3.63436919 0.000278662 0.007933147 6.010120033 6.86795045 6 Ccl9 ENSMUSG00000019122.7 355.7845119 1.061211742 0.284584473 3.728986797 0.000192251 0.005967281 8.189680854 9.13763526 6 Ccnb2 ENSMUSG00000032218.6 220.2121918 0.991769258 0.316289611 3.135636526 0.001714816 0.032395796 7.704080154 8.543339461 6 Cd1d1 ENSMUSG00000028076.6 636.1713162 -1.0590528 0.300993726 -3.518521176 0.000433959 0.011422251 9.872852329 8.85406508 6 Cd1d2 ENSMUSG00000041750.7 199.8578427 -1.158910496 0.327403243 -3.539703773 0.000400576 0.010680734 8.46909052 7.518933525 6 Cd36 ENSMUSG00000002944.8 23098.16334 -1.978910604 0.400050229 -4.946655345 7.55E-07 5.22E-05 15.06942507 12.67526065 6 Cd74 ENSMUSG00000024610.8 204.115824 2.024350391 0.369039005 5.485464575 4.12E-08 4.12E-06 7.00282942 8.665739854 6 Cdhr3 ENSMUSG00000035860.8 60.61014797 -1.78561352 0.458197856 -3.897035957 9.74E-05 0.003441359 7.339594294 6.196257622 6 Cdkl2 ENSMUSG00000029403.8 423.6065767 -1.08954185 0.347586796 -3.134589297 0.001720949 0.032448468 9.33833824 8.311704789 6 Cdkn2c ENSMUSG00000028551.8 3406.949564 -1.279940587 0.399616822 -3.20291969 0.001360419 0.027439303 12.16421658 10.6950311 6 Cdo1 ENSMUSG00000033022.7 3418.03269 -1.267926991 0.353541743 -3.586357239 0.00033533 0.009210608 12.21146734 10.84086327 Page 63 of 79 Diabetes
6 Cdsn ENSMUSG00000039518.7 4036.525581 1.413359389 0.317615722 4.449903743 8.59E-06 0.000438857 11.01047822 12.51724918 6 Cebpa ENSMUSG00000034957.9 5541.625587 -1.85430366 0.375695802 -4.935651791 7.99E-07 5.48E-05 13.05380063 10.88686158 6 Cela1 ENSMUSG00000023031.7 419.5127811 -1.11077084 0.316854012 -3.505623405 0.000455539 0.011837049 9.34265039 8.323624708 6 Ces1f ENSMUSG00000031725.8 2052.568734 -2.410926911 0.292514011 -8.242090357 1.69E-16 7.12E-14 11.78277319 9.297487888 6 Cfd ENSMUSG00000061780.5 20633.76564 -1.676283075 0.384502791 -4.35961224 1.30E-05 0.00063025 14.86840027 12.89974942 6 Cfh ENSMUSG00000026365.9 1580.337104 2.63376652 0.428994975 6.139387808 8.28E-10 1.20E-07 8.057771267 11.52363409 6 Cfhr2 ENSMUSG00000033898.10 145.328988 2.409828775 0.454608576 5.300887191 1.15E-07 1.03E-05 6.233938428 8.40863935 6 Cfhr3 ENSMUSG00000090623.1 8.552269533 1.428243289 0.475860972 3.001387745 0.002687521 0.04557391 5.412824391 6.214169763 6 Cgn ENSMUSG00000068876.7 38.80718644 1.325174792 0.43900438 3.018591278 0.002539529 0.04392742 6.218127909 6.973735195 6 Chd5 ENSMUSG00000005045.9 67.90043206 1.189678945 0.387783004 3.067898626 0.002155697 0.038717552 6.61904048 7.392808714 6 Chdh ENSMUSG00000015970.11 14.19947276 -1.469725206 0.486341301 -3.022003688 0.002511075 0.043481105 6.42666274 5.663963692 6 Chn1 ENSMUSG00000056486.10 66.22150668 -1.81149489 0.410175456 -4.416390261 1.00E-05 0.000503287 7.479952436 6.333230093 6 Chn2 ENSMUSG00000004633.9 45.88032744 -1.518789338 0.425436881 -3.569952221 0.000357046 0.009661462 7.141528008 6.239313782 6 Chpt1 ENSMUSG00000060002.8 4070.436522 -1.211575956 0.363412618 -3.333885221 0.00085642 0.019218905 12.40683619 11.13448595 6 Chst15 ENSMUSG00000030930.7 141.075488 -1.206050557 0.331650672 -3.636508704 0.000276358 0.007881258 8.101002497 7.186929937 6 Chst8 ENSMUSG00000060402.6 67.64364534 -1.208527707 0.376882121 -3.206646426 0.001342919 0.027153135 7.394638489 6.620004554 6 Cib2 ENSMUSG00000037493.6 941.4262463 -1.943330267 0.339715334 -5.720466738 1.06E-08 1.23E-06 10.61380169 8.614673763 6 Cidec ENSMUSG00000030278.5 35827.0676 -1.966243324 0.410674392 -4.787840105 1.69E-06 0.000107987 15.70851349 13.22219216 6 Clcn2 ENSMUSG00000022843.10 371.0728445 -0.936035062 0.29626779 -3.159422299 0.001580822 0.030467511 9.154588546 8.29551551 6 Cldn15 ENSMUSG00000001739.7 2797.166175 -1.220725551 0.222956248 -5.475179814 4.37E-08 4.29E-06 11.98372069 10.72903946 6 Clec14a ENSMUSG00000045930.2 548.7026801 -0.795886455 0.253122682 -3.144271578 0.001665008 0.031811465 9.609966743 8.861085899 6 Clmn ENSMUSG00000021097.7 109.5612257 -1.681586812 0.36934202 -4.552925805 5.29E-06 0.000296087 7.952276816 6.727828202 6 Clstn3 ENSMUSG00000008153.5 221.1556634 -1.572806467 0.416287759 -3.778171312 0.000157984 0.005049951 8.636314933 7.223269331 6 Clybl ENSMUSG00000025545.8 755.7480659 -1.240493587 0.363652343 -3.411207466 0.000646759 0.015527888 10.11028413 8.867019862 6 Cmpk2 ENSMUSG00000020638.7 356.7043091 3.164943799 0.393032333 8.052629604 8.10E-16 3.09E-13 6.666210669 9.515092392 6 Cndp1 ENSMUSG00000056162.7 94.92262706 -1.918142578 0.381269415 -5.030937456 4.88E-07 3.62E-05 7.833062806 6.52093275 6 Cnn2 ENSMUSG00000004665.4 7645.984285 0.835629987 0.26662112 3.134147762 0.00172354 0.032448468 12.36894888 13.29572726 6 Cnnm2 ENSMUSG00000064105.5 1421.420335 -1.234360429 0.260598141 -4.736643253 2.17E-06 0.000135995 11.03558582 9.778503507 6 Cnr1 ENSMUSG00000044288.6 39.63394875 -1.422819846 0.438943958 -3.241461287 0.001189186 0.024936406 7.006052624 6.188328727 6 Col15a1 ENSMUSG00000028339.11 5848.057878 -2.000739864 0.365256395 -5.477631299 4.31E-08 4.28E-06 13.14421582 10.88190176 6 Col8a1 ENSMUSG00000068196.4 196.5101024 1.677781424 0.357836774 4.688678039 2.75E-06 0.000167623 7.170295056 8.587046645 6 Coq5 ENSMUSG00000041733.4 1917.625402 -1.149250751 0.355019298 -3.237150084 0.001207299 0.025155386 11.36158627 10.14754561 6 Cox6a1 ENSMUSG00000041697.8 5674.24348 -0.9570175 0.297571015 -3.216097845 0.001299465 0.026503271 12.86862273 11.86886755 6 Cox6b1 ENSMUSG00000036751.6 3040.422641 -0.84877695 0.256326262 -3.311314815 0.000928587 0.020438881 11.96654452 11.0917795 6 Cox7b ENSMUSG00000031231.4 2859.361956 -0.819394912 0.273778096 -2.992916243 0.002763256 0.046617147 11.86115483 11.01910332 6 Cpeb2 ENSMUSG00000039782.7 740.4471145 -0.842538929 0.258966959 -3.253461106 0.001140083 0.0240053 10.01857662 9.20230568 6 Cpt2 ENSMUSG00000028607.9 2800.738856 -1.179908765 0.336849462 -3.502777641 0.000460434 0.01189444 11.9249 10.65973466 6 Cs ENSMUSG00000005683.7 13180.28949 -1.115809082 0.364511113 -3.061111289 0.002205171 0.039374274 14.06439222 12.86103957 6 Csf1 ENSMUSG00000014599.4 5763.247668 1.026820129 0.335885079 3.057057884 0.002235211 0.039753787 11.72015864 12.96769328 6 Csf2rb ENSMUSG00000071713.3 102.0971698 -1.341457909 0.370389409 -3.621750183 0.000292617 0.008244549 7.794625486 6.842432747 6 Csl ENSMUSG00000046934.4 549.6539747 -1.137818242 0.380893848 -2.987231873 0.002815161 0.047288438 9.636485189 8.543337285 6 Csmd1 ENSMUSG00000060924.7 29.6465394 2.711749474 0.4665027 5.81293414 6.14E-09 7.51E-07 5.625324709 6.944031554 6 Ctdspl ENSMUSG00000047409.7 1429.015346 -0.831142677 0.260396086 -3.191840126 0.001413696 0.028316919 10.90378639 10.0681534 6 Ctsc ENSMUSG00000030560.9 87.07269194 -1.23719311 0.366596973 -3.37480449 0.000738681 0.017108614 7.632923706 6.773331221 6 Cxcl10 ENSMUSG00000034855.7 135.8159755 2.211780982 0.385334071 5.739905054 9.47E-09 1.13E-06 6.575107191 8.275756773 6 Cxcl11 ENSMUSG00000060183.6 10.0808815 1.612333603 0.481283196 3.35007251 0.000807904 0.018298358 5.412824391 6.292276243 6 Cycs ENSMUSG00000063694.5 6220.28862 -1.52154522 0.363780377 -4.182592891 2.88E-05 0.001230718 13.12323908 11.42878925 6 Cyp51 ENSMUSG00000001467.4 2683.00931 -1.124830652 0.296996849 -3.787348769 0.000152263 0.004914987 11.8780617 10.6844393 6 Cyr61 ENSMUSG00000028195.3 707.0957641 0.858492879 0.269359609 3.187162623 0.00143676 0.028661782 9.122105122 9.968000388 6 D10Jhu81e ENSMUSG00000053329.6 1237.117074 -0.970874913 0.32370789 -2.999231537 0.002706615 0.045850288 10.72418727 9.73858779 6 D14Ertd668e ENSMUSG00000068245.7 448.3889312 2.87167665 0.298434835 9.622457946 6.43E-22 5.55E-19 7.27164698 9.787369555 6 D4Bwg0951e ENSMUSG00000048706.3 943.5803529 1.006754261 0.249803324 4.030187605 5.57E-05 0.002140279 9.40899261 10.40311947 6 D5Ertd579e ENSMUSG00000029190.12 4252.381198 -0.968513308 0.27896299 -3.471834405 0.000516915 0.012980664 12.473806 11.46588664 6 Dach2 ENSMUSG00000025592.10 47.15909536 2.348001355 0.44401556 5.288106014 1.24E-07 1.08E-05 5.925167791 7.257915749 6 Dapk1 ENSMUSG00000021559.7 1583.115731 -1.597260419 0.229976081 -6.945332809 3.78E-12 7.46E-10 11.28406926 9.683799088 6 Dbi ENSMUSG00000026385.9 5389.137097 -1.362199996 0.316025848 -4.310406903 1.63E-05 0.000767852 12.93453374 11.43929077 6 Dbt ENSMUSG00000000340.6 2300.017159 -1.706813381 0.435123379 -3.922596361 8.76E-05 0.003164014 11.55029611 9.649661011 6 Ddit4 ENSMUSG00000020108.3 990.3556336 0.706022975 0.235825527 2.993836097 0.002754939 0.046524705 9.667695564 10.36522277 6 Ddx58 ENSMUSG00000040296.8 2752.932012 1.755440588 0.26877718 6.531211419 6.52E-11 1.09E-08 10.24136564 12.11285168 6 Ddx60 ENSMUSG00000037921.8 584.5166472 3.42181289 0.300914815 11.37136733 5.81E-30 1.19E-26 7.155421131 10.18841772 6 Dennd2d ENSMUSG00000027901.5 274.1819337 -2.302325339 0.371938113 -6.190076402 6.01E-10 8.96E-08 9.031198409 7.080938623 6 Dgat1 ENSMUSG00000022555.5 4220.518981 -1.497766287 0.345203513 -4.338792139 1.43E-05 0.000686932 12.60033343 10.93594364 6 Dgat2 ENSMUSG00000030747.4 7320.175257 -2.079610583 0.417496747 -4.981142006 6.32E-07 4.55E-05 13.42059418 10.82313466 6 Dgkd ENSMUSG00000070738.4 3080.855894 -0.954155797 0.32209541 -2.962339007 0.003053114 0.049915222 11.97951722 10.99849998 6 Dhcr7 ENSMUSG00000058454.8 1890.710257 -0.933396944 0.242046995 -3.856263301 0.000115133 0.00392507 11.34330734 10.37701336 6 Dhrs3 ENSMUSG00000066026.7 465.1777723 -1.115544379 0.376040707 -2.966552181 0.003011593 0.049532692 9.432948278 8.367836079 6 Dhx58 ENSMUSG00000017830.8 621.0715895 2.475074273 0.335335453 7.380890537 1.57E-13 3.91E-11 7.738452684 10.18907269 6 Diap3 ENSMUSG00000022021.6 304.114627 1.247265238 0.334573989 3.72792052 0.000193066 0.005973397 7.847588556 9.013501855 6 Disp2 ENSMUSG00000040035.7 333.6271375 -1.74889771 0.392094426 -4.460399319 8.18E-06 0.000420524 9.150992971 7.558564707 6 Dlc1 ENSMUSG00000031523.8 6103.806351 -0.91244877 0.254181205 -3.589757041 0.000330986 0.009128782 12.980849 12.0272562 6 Dld ENSMUSG00000020664.8 6096.479401 -1.301266862 0.367708249 -3.538856864 0.000401864 0.010688698 13.01615069 11.60040119 6 Dlk2 ENSMUSG00000047428.7 27.77175271 1.654555101 0.454424383 3.640991028 0.000271591 0.007813233 5.95336635 6.802861257 6 Dmd ENSMUSG00000045103.10 133.9397796 2.469680147 0.365105726 6.764287637 1.34E-11 2.55E-09 6.513110557 8.258891531 6 Dmrtc2 ENSMUSG00000011349.5 22.5306501 -1.717142506 0.485391326 -3.537645636 0.000403711 0.010712073 6.641064917 5.734061236 6 Dmxl2 ENSMUSG00000041268.10 593.7841392 -1.002741448 0.247853652 -4.04569971 5.22E-05 0.002027099 9.783941726 8.834194031 6 Dnajb9 ENSMUSG00000014905.3 1759.044739 -1.117959024 0.338658128 -3.301143339 0.000962917 0.02095212 11.23662665 10.08990081 6 Dnajc15 ENSMUSG00000022013.3 670.1290727 -1.023237643 0.335082929 -3.053684784 0.002260495 0.040073071 9.90273991 8.918926874 6 Dpt ENSMUSG00000026574.4 5184.388488 1.706341044 0.223105563 7.648133124 2.04E-14 5.97E-12 11.21826262 12.98809023 6 Dtna ENSMUSG00000024302.8 318.0507025 1.812105341 0.363963213 4.978814549 6.40E-07 4.56E-05 7.481250687 9.207788874 6 Dtx3l ENSMUSG00000049502.10 1117.998264 1.300396186 0.2550863 5.097867604 3.44E-07 2.66E-05 9.423364672 10.72524019 6 Dusp22 ENSMUSG00000069255.6 508.4375825 -1.109925619 0.290507689 -3.820641105 0.000133105 0.004391669 9.600182326 8.56228559 6 Dusp4 ENSMUSG00000031530.6 1081.686339 -2.02954354 0.416301062 -4.875182235 1.09E-06 7.37E-05 10.78472904 8.397978799 6 Dusp6 ENSMUSG00000019960.6 492.5499054 -1.252810527 0.333551144 -3.755977306 0.000172666 0.005455458 9.59256065 8.384203081 6 Dysf ENSMUSG00000033788.9 892.7236039 -0.842861424 0.268989917 -3.133431297 0.001727754 0.032453269 10.26341076 9.438148979 6 Ear-ps2 ENSMUSG00000072599.3 20.98975214 -1.420183519 0.473096962 -3.00188679 0.002683119 0.04557391 6.603398769 5.888112071 6 Ear1 ENSMUSG00000072601.3 25.45203008 -1.93864193 0.465576809 -4.163957252 3.13E-05 0.001321893 6.776513715 5.817666663 Diabetes Page 64 of 79
6 Ear10 ENSMUSG00000090166.2 23.00950715 -1.70280991 0.475683119 -3.579714821 0.000343969 0.009385041 6.691203887 5.809741288 6 Ear2 ENSMUSG00000072596.4 43.47553429 -1.836674611 0.434439934 -4.227683662 2.36E-05 0.00103522 7.138655794 6.088223342 6 Echdc1 ENSMUSG00000019883.4 859.865769 -1.578805939 0.356630274 -4.427010421 9.55E-06 0.000482092 10.38208624 8.773821718 6 Echdc2 ENSMUSG00000028601.11 1141.268907 -0.787850422 0.237352413 -3.319327633 0.000902345 0.020022533 10.58729978 9.803881309 6 Echs1 ENSMUSG00000025465.6 3448.138212 -1.235094303 0.376981941 -3.276269153 0.001051883 0.02248862 12.17044781 10.84670029 6 Ecm1 ENSMUSG00000028108.8 2941.804811 1.519483835 0.261003049 5.821709144 5.82E-09 7.24E-07 10.54377917 12.13465643 6 Ecscr ENSMUSG00000073599.3 27.05132812 2.021116237 0.462047627 4.374259537 1.22E-05 0.000594649 5.814995216 6.829495721 6 Eda2r ENSMUSG00000034457.4 728.6587381 1.242428057 0.271179338 4.581573463 4.61E-06 0.000264599 8.909919067 10.12992758 6 Efnb2 ENSMUSG00000001300.8 1391.208035 1.058539353 0.281581511 3.759264409 0.000170414 0.005394678 9.84206588 10.96333199 6 Ehd4 ENSMUSG00000027293.7 805.899489 0.8671409 0.248751542 3.485971964 0.000490352 0.01250513 9.29652517 10.14471071 6 Eif2ak2 ENSMUSG00000024079.4 2696.218949 1.165920697 0.224662833 5.189646547 2.11E-07 1.75E-05 10.71682924 11.91452794 6 Elovl6 ENSMUSG00000041220.6 508.3645845 0.910390849 0.282905654 3.218001604 0.001290871 0.026360775 8.690763428 9.539883499 6 Emilin2 ENSMUSG00000024053.9 96.42005378 -1.555081782 0.413575628 -3.760090483 0.000169852 0.005387295 7.774100039 6.636946449 6 Emx2 ENSMUSG00000043969.3 146.9183439 1.140958025 0.317829072 3.589847889 0.000330871 0.009128782 7.255544361 8.138117881 6 Enpp6 ENSMUSG00000038173.8 8.341700232 -1.454141186 0.474439777 -3.064964736 0.002176957 0.039056603 6.20304185 5.393604924 6 Entpd5 ENSMUSG00000021236.10 1103.187608 -1.322840759 0.323040208 -4.094972467 4.22E-05 0.001709516 10.68021588 9.331165153 6 Epas1 ENSMUSG00000024140.9 1516.112708 -1.586981879 0.308603659 -5.142459696 2.71E-07 2.17E-05 11.20626219 9.54656314 6 Epb4.1l4a ENSMUSG00000024376.6 264.0375416 1.040014567 0.30626537 3.395795502 0.000684295 0.016207641 7.865804849 8.771734638 6 Epha2 ENSMUSG00000006445.3 322.8403806 1.044889313 0.330778614 3.158878082 0.001583777 0.030482136 8.027361974 9.037728442 6 Eps8 ENSMUSG00000015766.8 1527.987415 0.803905539 0.251522621 3.196156016 0.001392718 0.027987484 10.17512045 10.99403994 6 Ereg ENSMUSG00000029377.4 139.7727767 1.072801718 0.343574794 3.122469219 0.001793409 0.033494663 7.22285563 8.070064628 6 Etfa ENSMUSG00000032314.8 4298.177968 -1.062113638 0.328277042 -3.235418569 0.001214645 0.025276336 12.48208655 11.37477809 6 Etfb ENSMUSG00000004610.3 3475.243145 -1.080099895 0.318582056 -3.390335003 0.000698073 0.016423235 12.20409336 11.06577912 6 Etfdh ENSMUSG00000027809.8 3155.191242 -1.128265448 0.354462758 -3.183029594 0.001457427 0.028968352 12.05278272 10.84485078 6 Etv4 ENSMUSG00000017724.8 98.39435511 2.149831374 0.449583903 4.781824612 1.74E-06 0.000110408 6.24335328 7.904357607 6 Extl3 ENSMUSG00000021978.7 4019.058827 -0.856041671 0.239013102 -3.581567967 0.000341538 0.009334241 12.37058173 11.48325055 6 F630110N24Rik ENSMUSG00000034854.8 2168.619087 -1.287116742 0.366110276 -3.515653144 0.000438674 0.011527838 11.56635556 10.17699229 6 F830016B08Rik ENSMUSG00000090942.1 143.9064162 2.761179696 0.364250825 7.580434979 3.44E-14 9.42E-12 6.425542659 8.374911975 6 Fa2h ENSMUSG00000033579.9 39.02713554 -1.933925462 0.47769902 -4.048418313 5.16E-05 0.00200846 7.012639634 5.874109204 6 Fabp4 ENSMUSG00000062515.2 48799.36274 -1.701657237 0.401220439 -4.24120277 2.22E-05 0.000990676 16.08718065 14.03333634 6 Fabp5 ENSMUSG00000027533.9 6988.49753 -1.338219436 0.295489433 -4.528823322 5.93E-06 0.000321274 13.31569336 11.84518358 6 Fam107a ENSMUSG00000021750.9 64.58789423 -2.103898048 0.411434315 -5.113569699 3.16E-07 2.48E-05 7.501301629 6.197895137 6 Fam110c ENSMUSG00000036136.8 682.5804085 -1.63721374 0.347625939 -4.709699589 2.48E-06 0.000152934 10.11077095 8.461525907 6 Fam126b ENSMUSG00000038174.8 1276.745474 -1.398174052 0.279941648 -4.994519608 5.90E-07 4.26E-05 10.92069339 9.51105871 6 Fam132a ENSMUSG00000023571.4 194.5671936 -1.39275588 0.468088524 -2.97541129 0.00292596 0.048710544 8.253839486 7.072873801 6 Fam158a ENSMUSG00000022217.8 444.7298948 -1.074500425 0.345142347 -3.113209477 0.001850646 0.034329067 9.39111931 8.383830371 6 Fam171b ENSMUSG00000048388.3 401.1982561 1.561265003 0.271666719 5.746986643 9.08E-09 1.09E-06 8.020255096 9.430696583 6 Fam195a ENSMUSG00000025732.5 513.7226107 -1.473669696 0.422268441 -3.489888306 0.000483222 0.012381066 9.632724698 8.06185979 6 Fam198b ENSMUSG00000027955.10 603.4523986 1.018272633 0.261771956 3.889922546 0.000100276 0.003519165 8.840065816 9.804575322 6 Fam40b ENSMUSG00000039629.8 678.4038523 -0.96783062 0.261392632 -3.702593351 0.000213407 0.006516657 9.943733432 9.01416958 6 Fam49b ENSMUSG00000022378.7 1477.286671 -1.162013322 0.360393767 -3.224288065 0.001262863 0.025917931 10.99574506 9.784307973 6 Fam69a ENSMUSG00000029270.4 1018.333175 -0.884422646 0.269274731 -3.284462088 0.001021772 0.021959403 10.46049921 9.576909396 6 Fam73b ENSMUSG00000026858.11 2044.060449 -1.33103873 0.341785388 -3.894369904 9.85E-05 0.003471944 11.51862675 10.10835948 6 Fam83a ENSMUSG00000051225.3 889.1389028 -1.692249002 0.376439635 -4.495406027 6.94E-06 0.000369686 10.4635284 8.652279015 6 Fam84b ENSMUSG00000072568.3 8.812183021 1.534177405 0.471563511 3.253384476 0.001140391 0.0240053 5.292968574 6.226978285 6 Fbxo45 ENSMUSG00000035764.5 1156.800471 -0.834839083 0.277892965 -3.004174943 0.002663022 0.045298991 10.61159465 9.773476005 6 Ffar2 ENSMUSG00000051314.5 418.578014 -2.304285561 0.400464388 -5.754033637 8.71E-09 1.05E-06 9.549185794 7.330255259 6 Fgd3 ENSMUSG00000037946.5 40.76993107 1.376939055 0.464731644 2.962869158 0.003047861 0.049915222 6.123635449 7.050537603 6 Fgfr2 ENSMUSG00000030849.10 2165.529027 -0.905919942 0.251582604 -3.600884673 0.000317136 0.008844218 11.51349115 10.58396664 6 Fgfr3 ENSMUSG00000054252.9 339.5362828 -1.490337873 0.389714157 -3.824182019 0.000131207 0.004355471 9.113336988 7.762630553 6 Fgfrl1 ENSMUSG00000008090.8 4713.664118 -0.945272922 0.246386012 -3.836552717 0.000124773 0.004201303 12.62853177 11.64108329 6 Fhod3 ENSMUSG00000034295.8 74.5971593 2.298423719 0.376928551 6.097770294 1.08E-09 1.52E-07 6.260163369 7.655580221 6 Fibin ENSMUSG00000074971.3 244.1346115 1.098490828 0.296222803 3.708326362 0.000208634 0.006382788 7.764205439 8.692705328 6 Fitm2 ENSMUSG00000048486.6 4389.194579 -1.546676146 0.367719238 -4.206133335 2.60E-05 0.001126937 12.64007248 10.89914417 6 Flnb ENSMUSG00000025278.8 6508.423226 0.864234363 0.253351043 3.411212968 0.000646746 0.015527888 12.13442882 13.07337951 6 Flrt2 ENSMUSG00000047414.5 1454.219537 1.341080558 0.313733931 4.274579277 1.91E-05 0.000884562 9.63635758 11.12549709 6 Fmo1 ENSMUSG00000040181.8 237.7016418 -1.447143594 0.419250895 -3.451736445 0.000556991 0.013755341 8.705453105 7.343685709 6 Fn1 ENSMUSG00000026193.8 110759.0866 0.980037009 0.269318781 3.638947891 0.000273754 0.007847939 16.11166427 17.17972822 6 Foxg1 ENSMUSG00000020950.8 11.21132626 1.887099575 0.48263148 3.910021733 9.23E-05 0.003297028 5.292968574 6.357702285 6 Foxp2 ENSMUSG00000029563.10 21.09613973 1.875803547 0.477893159 3.925152542 8.67E-05 0.003148157 5.722807789 6.668344194 6 Foxred1 ENSMUSG00000039048.8 1163.120188 -0.990113049 0.332189207 -2.980569588 0.002877129 0.048043946 10.63028155 9.645157103 6 Frat2 ENSMUSG00000047604.2 119.3854964 -1.516300598 0.39420509 -3.846476455 0.000119829 0.004059814 7.967398145 6.84415426 6 Frk ENSMUSG00000019779.8 668.7844732 1.092841622 0.297074535 3.678678216 0.000234446 0.007009557 8.86776694 9.982461512 6 Fsd2 ENSMUSG00000038663.7 59.33047995 -1.747614274 0.456605449 -3.827405645 0.000129501 0.004324964 7.334105595 6.197895137 6 Fxyd1 ENSMUSG00000036570.7 264.675486 -0.978731847 0.282860633 -3.460120397 0.000539934 0.013394609 8.763301526 7.911914909 6 Fzd3 ENSMUSG00000007989.5 174.7264786 -0.918388518 0.295997378 -3.102691395 0.001917695 0.035214292 8.263959283 7.532962751 6 Fzd4 ENSMUSG00000049791.3 1355.812408 -0.968136683 0.244089964 -3.966310897 7.30E-05 0.002726537 10.89183664 9.907360988 6 G0s2 ENSMUSG00000009633.2 2192.641957 -2.324146147 0.43515122 -5.341007995 9.24E-08 8.52E-06 11.639708 8.881483486 6 Gale ENSMUSG00000028671.10 635.7744055 -1.240771071 0.356325142 -3.482131698 0.000497439 0.012646518 9.901589057 8.660779932 6 Gap43 ENSMUSG00000047261.9 34.48712555 2.035638126 0.444671791 4.577844075 4.70E-06 0.000267488 5.928259305 6.993120455 6 Gbp10 ENSMUSG00000054588.7 2169.306296 1.637090387 0.278137235 5.885908765 3.96E-09 5.11E-07 10.00260151 11.74857911 6 Gbp11 ENSMUSG00000092021.1 254.1786339 1.434491453 0.331874499 4.322391324 1.54E-05 0.000735751 7.584462571 8.817781544 6 Gbp2 ENSMUSG00000028270.6 1116.678293 1.062058215 0.24837707 4.275991394 1.90E-05 0.000881455 9.587537303 10.65432203 6 Gbp3 ENSMUSG00000028268.8 949.524152 2.469241021 0.280070793 8.816488825 1.18E-18 6.92E-16 8.335427344 10.73480575 6 Gbp4 ENSMUSG00000079363.2 428.9059994 2.48303946 0.285635015 8.693049962 3.53E-18 1.81E-15 7.500008863 9.671308035 6 Gbp6 ENSMUSG00000079362.2 2877.906509 1.62972165 0.269895342 6.03834671 1.56E-09 2.15E-07 10.40571964 12.14092499 6 Gbp7 ENSMUSG00000040253.9 1451.679469 1.68482839 0.363737082 4.631995125 3.62E-06 0.000213622 9.233660984 11.21457971 6 Gbp8 ENSMUSG00000034438.9 282.9435965 2.038263485 0.324239643 6.286287108 3.25E-10 4.98E-08 7.337492437 9.072512492 6 Gbp9 ENSMUSG00000029298.8 739.1008861 2.954138287 0.339257883 8.707648183 3.10E-18 1.64E-15 7.57455379 10.44926261 6 Gchfr ENSMUSG00000046814.3 453.5376506 -1.412136892 0.429178206 -3.290327587 0.001000708 0.021563221 9.366521035 8.014264482 6 Gcnt2 ENSMUSG00000021360.8 353.7765744 -1.337464972 0.404899834 -3.303199608 0.000955883 0.020850219 9.108819105 7.872820244 6 Gda ENSMUSG00000058624.6 1731.945478 -1.345850766 0.264432311 -5.089585169 3.59E-07 2.76E-05 11.33991372 9.958257163 6 Gdf10 ENSMUSG00000021943.5 26.82842888 -1.523842266 0.486156033 -3.134471571 0.001721639 0.032448468 6.747601603 5.723124767 6 Gdf5 ENSMUSG00000038259.3 126.8396378 -1.542167155 0.396098306 -3.89339498 9.89E-05 0.003478452 8.049689131 6.857022685 6 Ghr ENSMUSG00000055737.6 19915.53979 -0.897747166 0.212167511 -4.231313089 2.32E-05 0.00102413 14.68239346 13.7410646 6 Gja1 ENSMUSG00000050953.8 644.1478613 1.43590961 0.278412127 5.157496648 2.50E-07 2.04E-05 8.626446899 10.01547855 Page 65 of 79 Diabetes
6 Glns-ps1 ENSMUSG00000082100.1 1268.817809 -1.238533906 0.36478422 -3.395250777 0.000685658 0.016207641 10.82485349 9.500036004 6 Glul ENSMUSG00000026473.9 10978.81474 -1.281392221 0.356881199 -3.590528798 0.000330008 0.009128782 13.89688238 12.44094697 6 Gm10053 ENSMUSG00000058927.4 2808.790525 -1.569489143 0.351507232 -4.465026602 8.01E-06 0.000414134 12.02035511 10.31739863 6 Gm10108 ENSMUSG00000062038.3 2882.628829 -1.568599039 0.357320676 -4.389891617 1.13E-05 0.000559198 12.0525541 10.33859617 6 Gm10121 ENSMUSG00000062813.6 1428.775113 -1.620087751 0.362941643 -4.463769267 8.05E-06 0.000415263 11.08193867 9.352322193 6 Gm10499 ENSMUSG00000073403.4 1314.765369 0.955920167 0.260149298 3.674506042 0.00023831 0.00706656 9.859729224 10.84834498 6 Gm10687 ENSMUSG00000074408.2 115.5049158 -1.582656507 0.387438242 -4.084925889 4.41E-05 0.001767732 7.978690703 6.777287065 6 Gm11127 ENSMUSG00000079492.2 2308.254364 0.981901393 0.257465313 3.813723023 0.000136889 0.004489408 10.60444263 11.64007555 6 Gm11618 ENSMUSG00000083991.1 172.7456438 -1.700976285 0.405255672 -4.197291746 2.70E-05 0.001162605 8.38142556 6.991807415 6 Gm11625 ENSMUSG00000080839.1 649.9321624 -1.531453086 0.35570662 -4.305382588 1.67E-05 0.000778776 10.00025152 8.481325036 6 Gm11942 ENSMUSG00000059634.3 7045.637564 0.688133696 0.23027075 2.98836781 0.002804718 0.047219472 12.39134497 13.10919313 6 Gm12003 ENSMUSG00000083859.1 1039.710436 0.815993206 0.247442796 3.297704436 0.000974787 0.021143591 9.65391479 10.47478845 6 Gm12185 ENSMUSG00000048852.7 78.59695123 2.108901261 0.372806541 5.656824738 1.54E-08 1.73E-06 6.360425671 7.681758012 6 Gm12222 ENSMUSG00000060068.6 327.3963612 -1.346022083 0.316593501 -4.251578381 2.12E-05 0.000951036 9.110467036 7.900005283 6 Gm12250 ENSMUSG00000082292.2 307.5537521 3.184853489 0.291515454 10.92516176 8.74E-28 1.30E-24 6.822860104 9.325661332 6 Gm12505 ENSMUSG00000087070.1 42.95616727 -2.37916384 0.456770416 -5.208664478 1.90E-07 1.61E-05 7.179016176 5.840882573 6 Gm12715 ENSMUSG00000059195.8 27340.36572 0.827275876 0.245398861 3.371147991 0.000748556 0.017215746 14.21837869 15.11860481 6 Gm12840 ENSMUSG00000086320.1 25.98856958 -1.415724467 0.464788326 -3.045955306 0.002319423 0.040940689 6.722138426 5.981902912 6 Gm13131 ENSMUSG00000081772.1 161.566377 -1.285317533 0.406558413 -3.16145846 0.001569812 0.030381762 8.206963388 7.182544837 6 Gm13252 ENSMUSG00000084105.1 317.6088794 -1.546618777 0.379440024 -4.076055976 4.58E-05 0.001818709 9.070994334 7.667876787 6 Gm13669 ENSMUSG00000081833.1 384.3548855 0.901455543 0.25846273 3.487758345 0.000487088 0.012460641 8.37882169 9.191623835 6 Gm13772 ENSMUSG00000080977.1 1650.301412 -1.558920187 0.35635994 -4.374566312 1.22E-05 0.000594649 11.27439279 9.603551463 6 Gm13910 ENSMUSG00000063684.7 2358.057694 -1.334488272 0.39556779 -3.373601959 0.000741916 0.017135117 11.64612952 10.18191944 6 Gm13998 ENSMUSG00000081056.1 163.3591325 -1.265652349 0.325399541 -3.889533291 0.000100437 0.003519165 8.285303519 7.273747314 6 Gm14238 ENSMUSG00000083341.1 190.2449765 -1.534479864 0.395372601 -3.881098135 0.000103986 0.00360499 8.468899876 7.179393698 6 Gm14328 ENSMUSG00000082401.1 560.3692729 -1.330231799 0.297101797 -4.477360327 7.56E-06 0.000393404 9.810645864 8.505868842 6 Gm14446 ENSMUSG00000079339.6 70.68586677 2.567583578 0.394778841 6.503853069 7.83E-11 1.30E-08 6.111585338 7.635795959 6 Gm14506 ENSMUSG00000081597.1 142.6824809 -1.348026634 0.430946153 -3.128062812 0.001759626 0.032938747 8.054736116 7.005404148 6 Gm14681 ENSMUSG00000081603.1 1322.46877 0.708580434 0.2243845 3.157884939 0.001589183 0.030514541 10.05373887 10.76196218 6 Gm15285 ENSMUSG00000081277.1 128.9324335 -1.119429754 0.377861815 -2.962537384 0.003051148 0.049915222 7.964251658 7.120778986 6 Gm15433 ENSMUSG00000073632.3 233.4456792 2.62759828 0.336341146 7.812301019 5.62E-15 1.81E-12 6.835607983 8.92764443 6 Gm15484 ENSMUSG00000081865.1 787.9666733 0.705173597 0.234305638 3.009631362 0.002615649 0.044876983 9.373175645 10.05744295 6 Gm15753 ENSMUSG00000082088.1 23.94192647 1.647650606 0.470055086 3.505228762 0.000456215 0.011837049 5.859406576 6.716368832 6 Gm16026 ENSMUSG00000079455.2 81.72825211 1.881846901 0.378250405 4.975135195 6.52E-07 4.63E-05 6.461697106 7.682674905 6 Gm16332 ENSMUSG00000089991.1 171.69824 2.842532554 0.396967109 7.160624865 8.03E-13 1.76E-10 6.393853263 8.589453064 6 Gm16340 ENSMUSG00000090222.1 492.3963714 2.086660423 0.30999732 6.731220854 1.68E-11 3.17E-09 7.833311943 9.814869651 6 Gm16439 ENSMUSG00000072594.3 454.5842307 -1.637308359 0.395057517 -4.144480962 3.41E-05 0.001417487 9.496427032 7.943654977 6 Gm16628 ENSMUSG00000085291.1 30.57423189 -1.79187021 0.486123383 -3.686039949 0.000227771 0.006865777 6.838788966 5.718430372 6 Gm16854 ENSMUSG00000085607.1 2673.560454 -2.273230436 0.339122279 -6.703276586 2.04E-11 3.73E-09 12.0994853 9.655261736 6 Gm17782 ENSMUSG00000092366.1 921.4965784 0.918798712 0.269885419 3.404402932 0.000663089 0.01587347 9.412238641 10.35077256 6 Gm1966 ENSMUSG00000073902.3 50.19274538 2.05196634 0.452208034 4.537660074 5.69E-06 0.000313003 6.007008465 7.287496218 6 Gm20419 ENSMUSG00000092215.1 376.6850917 -1.993051849 0.376802694 -5.289377917 1.23E-07 1.08E-05 9.387704163 7.525195442 6 Gm2619 ENSMUSG00000091199.1 147.9099081 2.417311627 0.391619929 6.172596057 6.72E-10 9.84E-08 6.526877247 8.371453052 6 Gm2635 ENSMUSG00000089763.1 142.9077321 2.547284769 0.353977898 7.19616899 6.19E-13 1.39E-10 6.529368933 8.350781224 6 Gm2666 ENSMUSG00000090189.3 163.2818655 2.418879417 0.337695137 7.16290865 7.90E-13 1.75E-10 6.695524193 8.485163242 6 Gm3452 ENSMUSG00000091498.1 467.3597775 -1.090676997 0.346065289 -3.151650946 0.001623502 0.031100689 9.449957664 8.436118967 6 Gm4070 ENSMUSG00000078606.1 2589.843198 2.734477967 0.296675356 9.217071492 3.05E-20 2.00E-17 9.28061768 12.17965193 6 Gm4285 ENSMUSG00000085829.1 143.247731 -1.233327434 0.405361802 -3.042534912 0.002345946 0.041187177 8.07341716 7.115699793 6 Gm4788 ENSMUSG00000070594.4 159.8976182 2.135170343 0.470076439 4.542176903 5.57E-06 0.000307782 6.283336145 8.510883348 6 Gm4841 ENSMUSG00000068606.4 26.33714477 1.414489642 0.453824778 3.116818891 0.001828138 0.033949959 6.010882015 6.737883522 6 Gm4902 ENSMUSG00000091649.1 118.347511 2.4417595 0.367620226 6.642070608 3.09E-11 5.34E-09 6.442834438 8.139696504 6 Gm4951 ENSMUSG00000073555.1 513.1300879 2.301221311 0.317722226 7.242871681 4.39E-13 1.03E-10 7.714456843 9.905543164 6 Gm5417 ENSMUSG00000049414.6 154.6850606 -1.045785892 0.326376929 -3.204227377 0.001354255 0.027348608 8.159396163 7.345556343 6 Gm5424 ENSMUSG00000046687.4 336.2234205 0.806158005 0.265797654 3.03297638 0.002421546 0.042198197 8.278783179 8.993554765 6 Gm5431 ENSMUSG00000058163.6 29.68037106 1.701433492 0.450032421 3.780690934 0.000156394 0.005018678 5.969500895 6.852922038 6 Gm5460 ENSMUSG00000072624.2 81.36985732 -1.637125623 0.365599936 -4.47791551 7.54E-06 0.000393404 7.643964608 6.569329803 6 Gm5514 ENSMUSG00000045104.8 396.8870459 -1.909366649 0.359250455 -5.314862158 1.07E-07 9.72E-06 9.457271547 7.666879745 6 Gm5529 ENSMUSG00000067106.5 2855.686909 -1.115883438 0.340991776 -3.272464368 0.001066143 0.022704694 11.91483267 10.74416776 6 Gm5560 ENSMUSG00000067161.4 3363.642661 -1.110434314 0.325108446 -3.415581255 0.00063646 0.015350865 12.15692565 10.99562672 6 Gm5815 ENSMUSG00000046952.7 57.82915711 -1.577148808 0.40153975 -3.927752623 8.57E-05 0.003124487 7.333063676 6.365581358 6 Gm5834 ENSMUSG00000085867.1 26.85644515 1.454909574 0.477293852 3.048247046 0.002301806 0.040717386 5.902574453 6.7750858 6 Gm6166 ENSMUSG00000074280.4 3692.411685 -1.329438928 0.299935691 -4.432413238 9.32E-06 0.000473076 12.40271833 10.95289541 6 Gm6169 ENSMUSG00000057762.3 1903.961698 0.900378105 0.228066825 3.947869689 7.88E-05 0.002918685 10.4224494 11.33635919 6 Gm6904 ENSMUSG00000090881.1 24.2140094 2.518640719 0.476337982 5.287507636 1.24E-07 1.08E-05 5.577691422 6.79960521 6 Gm6907 ENSMUSG00000091144.1 157.1819774 1.208708767 0.317370464 3.808510577 0.000139806 0.004566822 7.279851832 8.226608914 6 Gm7289 ENSMUSG00000092056.1 418.8895088 0.795942903 0.258961316 3.073597692 0.002114944 0.038068997 8.534695552 9.26704393 6 Gm7582 ENSMUSG00000061852.8 212.552784 2.463327937 0.37182249 6.625010598 3.47E-11 5.93E-09 6.783485601 8.786710766 6 Gm7592 ENSMUSG00000090186.3 802.1330103 2.692544749 0.312156634 8.625620786 6.37E-18 3.17E-15 7.912084326 10.54315988 6 Gm7609 ENSMUSG00000079457.3 422.538067 2.567417677 0.356056837 7.210696196 5.57E-13 1.29E-10 7.28002051 9.66916639 6 Gm7676 ENSMUSG00000068631.6 313.7412121 1.331141774 0.407116494 3.269682736 0.001076682 0.022899386 7.653486253 9.098774119 6 Gm7809 ENSMUSG00000086869.2 1493.14599 0.822011989 0.259217912 3.17112341 0.001518506 0.029608162 10.1175553 10.97818966 6 Gm8223 ENSMUSG00000091482.1 21.93639395 1.540160588 0.479927326 3.209153774 0.001331263 0.026950674 5.805639993 6.66395242 6 Gm8399 ENSMUSG00000043889.5 9949.211471 0.791210101 0.251810663 3.142083384 0.001677503 0.03191147 12.78965041 13.65340355 6 Gm8815 ENSMUSG00000092224.1 1060.058391 0.953403397 0.259255668 3.67746404 0.000235564 0.007023242 9.579928385 10.55174633 6 Gm8835 ENSMUSG00000092457.1 168.2190291 0.942212836 0.299717718 3.143667455 0.001668449 0.031811465 7.482796364 8.230781806 6 Gm8979 ENSMUSG00000091928.1 257.8224906 2.671867935 0.28835621 9.265858832 1.94E-20 1.38E-17 6.961082474 9.056885111 6 Gm8989 ENSMUSG00000091567.1 257.8224906 2.671867935 0.28835621 9.265858832 1.94E-20 1.38E-17 6.961082474 9.056885111 6 Gm9574 ENSMUSG00000073980.3 1115.554197 0.967512753 0.273980474 3.531320096 0.000413491 0.010936171 9.626449831 10.62450562 6 Gm9951 ENSMUSG00000054618.8 33.91816797 -1.690083771 0.486123098 -3.476658025 0.000507705 0.01281205 6.794581413 5.755274608 6 Gnb4 ENSMUSG00000027669.6 294.4554363 1.63357627 0.315870689 5.171661457 2.32E-07 1.90E-05 7.608121802 9.068603755 6 Gnb5 ENSMUSG00000032192.7 601.1547684 -1.07397842 0.29418372 -3.650706501 0.00026152 0.007579956 9.805931666 8.780968092 6 Gnpat ENSMUSG00000031985.3 6087.171517 -1.577664634 0.355402611 -4.439091288 9.03E-06 0.000460058 13.1150892 11.36909225 6 Gpd1 ENSMUSG00000023019.6 33519.68494 -1.6203476 0.434250516 -3.73136598 0.000190444 0.005948392 15.46198209 13.3633404 6 Gpr116 ENSMUSG00000056492.4 146.5054015 -1.818292529 0.469844601 -3.86998707 0.000108841 0.00374167 8.137540632 6.523898816 6 Gpr126 ENSMUSG00000039116.4 241.9720267 1.741955107 0.311506435 5.592035707 2.24E-08 2.41E-06 7.374877198 8.847344576 6 Gpr149 ENSMUSG00000043441.5 413.2690599 1.929153601 0.374793633 5.147242188 2.64E-07 2.14E-05 7.607851669 9.579908565 Diabetes Page 66 of 79
6 Gpr176 ENSMUSG00000040133.2 157.0559845 1.07093959 0.316216179 3.386732437 0.000707303 0.016546628 7.346250214 8.193082621 6 Gpr56 ENSMUSG00000031785.8 409.1827222 -1.585894593 0.389766407 -4.068833442 4.72E-05 0.001862478 9.36390199 7.883358994 6 Gprc5b ENSMUSG00000008734.8 3985.414174 -0.774010207 0.246237987 -3.143341998 0.001670306 0.031811465 12.32553639 11.52441831 6 Gpsm2 ENSMUSG00000027883.8 1254.796646 0.839041805 0.261331562 3.210640913 0.001324393 0.026895455 9.881028992 10.73622487 6 Greb1 ENSMUSG00000036523.9 201.8892059 -1.461986617 0.460643357 -3.173792904 0.00150461 0.029454623 8.418857845 7.047199581 6 Grhl1 ENSMUSG00000020656.9 164.4167068 -1.739473608 0.323539442 -5.376388112 7.60E-08 7.16E-06 8.388408938 7.051930263 6 Gria3 ENSMUSG00000001986.9 52.87359772 2.340387321 0.420782044 5.561994278 2.67E-08 2.79E-06 6.029424348 7.350989706 6 Grpel1 ENSMUSG00000029198.3 2437.825737 -1.076342545 0.325029712 -3.311520468 0.000927905 0.020438881 11.69063414 10.57968565 6 Gsdmd ENSMUSG00000022575.4 171.0955375 2.632426407 0.320619108 8.21044767 2.20E-16 8.81E-14 6.654455896 8.564197542 6 Gstz1 ENSMUSG00000021033.9 4642.582136 -1.895426353 0.374825387 -5.056824913 4.26E-07 3.22E-05 12.78007642 10.63581892 6 Gvin1 ENSMUSG00000045868.5 2544.318795 2.733410108 0.298361252 9.161411177 5.12E-20 3.23E-17 9.254332947 12.15453528 6 H2-Bl ENSMUSG00000073406.2 994.4985656 0.999109763 0.240758703 4.149838616 3.33E-05 0.001391779 9.483746405 10.47612771 6 H2-D1 ENSMUSG00000073411.4 14946.46599 1.188868781 0.232690752 5.109222315 3.23E-07 2.52E-05 13.1091358 14.3665165 6 H2-K1 ENSMUSG00000061232.8 8857.476307 0.801038061 0.26435352 3.030177392 0.002444101 0.042500928 12.60680448 13.49068405 6 H2-K2 ENSMUSG00000067203.6 1563.370456 1.028569892 0.262408588 3.919726484 8.86E-05 0.00319489 10.03921248 11.11210549 6 H2-Q10 ENSMUSG00000067235.7 1695.798699 1.035895826 0.254926587 4.063506429 4.83E-05 0.001891875 10.14950409 11.22756204 6 H2-Q4 ENSMUSG00000035929.10 1954.699602 1.364624644 0.242714434 5.622346482 1.88E-08 2.06E-06 10.12112645 11.52138586 6 H2-Q6 ENSMUSG00000073409.5 2135.202307 1.114352264 0.248502374 4.484272116 7.32E-06 0.000383495 10.41529942 11.57144933 6 H2-Q7 ENSMUSG00000060550.8 2168.126151 1.054484764 0.247064279 4.268058369 1.97E-05 0.00090571 10.47922219 11.57371266 6 H2-Q8 ENSMUSG00000055413.9 502.2052429 1.034458188 0.273510506 3.78215157 0.000155479 0.004999096 8.595158252 9.577737374 6 H2-T10 ENSMUSG00000079491.2 1514.139381 0.918539872 0.225157613 4.079541706 4.51E-05 0.001800372 10.10071329 11.02529019 6 H2-T22 ENSMUSG00000056116.11 2966.029865 0.959285271 0.245976147 3.899911771 9.62E-05 0.003410787 10.97524246 11.98531611 6 H2-T23 ENSMUSG00000067212.7 2706.833905 0.984035097 0.251245783 3.916623337 8.98E-05 0.003215078 10.82769566 11.8645063 6 H2-T24 ENSMUSG00000053835.10 560.4925074 1.000573826 0.272582901 3.670713832 0.000241874 0.007133544 8.743437403 9.713322154 6 H2-T3 ENSMUSG00000054128.10 358.0606758 1.011234923 0.288338675 3.507108166 0.000453005 0.011791072 8.211667837 9.14248714 6 H2afj ENSMUSG00000060032.4 1354.315152 -0.802072657 0.240033529 -3.341502588 0.000833262 0.018820712 10.82813254 10.01994626 6 Hadha ENSMUSG00000025745.5 8015.730736 -1.061859602 0.339209483 -3.130394801 0.001745715 0.032715699 13.37409987 12.22663347 6 Hadhb ENSMUSG00000059447.7 6298.225114 -1.341528709 0.392670328 -3.416424959 0.000634491 0.01534571 13.04412617 11.53561417 6 Hagh ENSMUSG00000024158.10 844.4703357 -0.909418253 0.302708129 -3.004274303 0.002662152 0.045298991 10.19908935 9.303438283 6 Hap1 ENSMUSG00000006930.8 20.88433422 1.83799368 0.479170704 3.835780575 0.000125166 0.004205889 5.722807789 6.657593279 6 Hbegf ENSMUSG00000024486.5 74.15974533 1.689442995 0.37092812 4.554637151 5.25E-06 0.000294693 6.490979226 7.566842312 6 Hdhd3 ENSMUSG00000038422.2 420.7002319 -1.310427877 0.367882234 -3.562085247 0.000367921 0.009922971 9.389979763 8.119035885 6 Hells ENSMUSG00000025001.5 590.9727274 0.877111216 0.286410111 3.062431041 0.002195471 0.039302758 8.870467695 9.744296676 6 Herc6 ENSMUSG00000029798.8 797.782359 2.072263298 0.27009757 7.672276709 1.69E-14 5.04E-12 8.436035626 10.4459163 6 Hibadh ENSMUSG00000029776.9 5547.584885 -1.222768643 0.348038466 -3.51331466 0.000442553 0.011592627 12.88797181 11.56609746 6 Hibch ENSMUSG00000041426.6 2260.230302 -1.631675452 0.400578625 -4.073296348 4.64E-05 0.001833217 11.65589474 9.832710982 6 Hipk2 ENSMUSG00000061436.8 6102.119045 -2.020033087 0.237072492 -8.520740096 1.59E-17 7.65E-15 13.29417855 11.16712447 6 Hk2 ENSMUSG00000000628.4 2398.730949 -1.231501063 0.365697762 -3.367537875 0.000758426 0.017418307 11.68087141 10.37031977 6 Hmcn1 ENSMUSG00000066842.11 97.23626393 1.825258454 0.4239434 4.30542958 1.67E-05 0.000778776 6.469557452 7.86706585 6 Hmga1 ENSMUSG00000046711.9 2996.87363 1.290886007 0.282571613 4.568349931 4.92E-06 0.000277007 10.73608606 12.07993337 6 Hmga2 ENSMUSG00000056758.8 1466.626686 1.497949189 0.366123126 4.091380965 4.29E-05 0.001727681 9.444643645 11.12683997 6 Hmgn5 ENSMUSG00000031245.8 239.0454937 -1.015670552 0.277564571 -3.659222598 0.000252982 0.007381479 8.648676874 7.797443812 6 Hoga1 ENSMUSG00000025176.8 36.95058149 -1.52186981 0.455694887 -3.339668394 0.000838785 0.018919386 6.98468913 6.072846265 6 Hoxd3 ENSMUSG00000079277.2 454.5033164 -0.852166016 0.271720486 -3.136186114 0.001711605 0.032372441 9.382822567 8.595566041 6 Hpd ENSMUSG00000029445.7 28.16394751 -1.790987004 0.485154156 -3.691583347 0.000222862 0.006730196 6.712480596 5.61923001 6 Hr ENSMUSG00000022096.8 74.23202176 -1.289818963 0.418345906 -3.083139918 0.002048288 0.03715468 7.492244195 6.582164544 6 Hrct1 ENSMUSG00000071001.3 129.2647386 -1.259532526 0.390830605 -3.222706999 0.001269854 0.025996332 7.997631363 7.035329615 6 Hs6st2 ENSMUSG00000062184.5 611.446408 1.510136841 0.356742845 4.233124394 2.30E-05 0.001021405 8.377634806 9.974591849 6 Hsd11b1 ENSMUSG00000016194.8 3665.371483 -2.798580851 0.319521058 -8.758674202 1.98E-18 1.12E-15 12.67473825 9.600565219 6 Hsd3b7 ENSMUSG00000042289.5 955.86822 -0.776760803 0.258076282 -3.009810889 0.002614104 0.044876983 10.33636705 9.571728967 6 Hsdl2 ENSMUSG00000028383.10 1385.657077 -1.183278167 0.344887089 -3.430914649 0.00060155 0.01467889 10.92249438 9.714267908 6 I830012O16Rik ENSMUSG00000062488.8 2527.708558 3.041385249 0.376370371 8.080830707 6.43E-16 2.51E-13 8.605168722 12.22064731 6 Ica1 ENSMUSG00000062995.5 95.78320289 1.148524649 0.354414989 3.240620984 0.001192696 0.02497808 6.88988303 7.704039743 6 Idh1 ENSMUSG00000025950.9 9387.038691 -0.899719913 0.251468714 -3.577860241 0.000346419 0.009420517 13.59335779 12.64844386 6 Idh3a ENSMUSG00000032279.9 4454.463163 -1.485433454 0.384587691 -3.862405085 0.000112276 0.003835635 12.60788497 10.94099325 6 Ifi202b ENSMUSG00000026535.8 1556.579645 1.923860745 0.244959845 7.853780072 4.04E-15 1.35E-12 9.394973462 11.33850932 6 Ifi203 ENSMUSG00000039997.10 2498.688713 2.140713522 0.281043359 7.617022263 2.60E-14 7.47E-12 9.770515978 12.05588525 6 Ifi204 ENSMUSG00000073489.3 2106.694175 1.098813666 0.244733361 4.489840127 7.13E-06 0.00037703 10.40765322 11.55092257 6 Ifi205 ENSMUSG00000054203.6 203.877298 1.671914187 0.298680388 5.597669801 2.17E-08 2.34E-06 7.287820594 8.619137948 6 Ifi27l2a ENSMUSG00000079017.3 477.6598094 2.726014226 0.258995452 10.52533627 6.60E-26 7.73E-23 7.483633115 9.84950366 6 Ifi27l2b ENSMUSG00000021208.8 34.86407556 1.573310941 0.452545857 3.476577931 0.000507857 0.01281205 6.060312076 6.935469999 6 Ifi30 ENSMUSG00000031838.6 514.9180977 1.088426113 0.338723555 3.213316867 0.001312114 0.026728016 8.555778417 9.580661847 6 Ifi35 ENSMUSG00000010358.7 755.5253235 1.471725636 0.251286196 5.856770731 4.72E-09 6.05E-07 8.820645053 10.23611145 6 Ifi44 ENSMUSG00000028037.7 1396.819069 3.584215261 0.304656328 11.76478194 5.93E-32 1.62E-28 7.850849212 11.37148188 6 Ifi47 ENSMUSG00000078920.2 582.3480102 1.938049188 0.385965672 5.02129938 5.13E-07 3.76E-05 7.89453556 10.03895554 6 Ifih1 ENSMUSG00000026896.7 377.16162 1.958172834 0.298323117 6.563932616 5.24E-11 8.86E-09 7.674779727 9.440381625 6 Ifit1 ENSMUSG00000034459.8 2105.105184 3.148341506 0.374776057 8.400594038 4.44E-17 2.08E-14 8.308313236 11.97192219 6 Ifit2 ENSMUSG00000045932.6 663.2072831 1.849090805 0.346990761 5.328933824 9.88E-08 9.05E-06 8.225348578 10.18194576 6 Ifit3 ENSMUSG00000074896.3 3228.665405 3.045649932 0.389563359 7.818111905 5.36E-15 1.76E-12 8.795503249 12.57444291 6 Ifitm1 ENSMUSG00000025491.8 282.0287324 1.296500681 0.350960072 3.694154363 0.00022062 0.006674765 7.709722774 8.946188589 6 Ifitm3 ENSMUSG00000025492.6 6329.058344 1.378275205 0.346736991 3.974987503 7.04E-05 0.002635022 11.52723773 13.22064817 6 Igf2 ENSMUSG00000048583.9 1942.387548 -1.468387072 0.407374798 -3.604511323 0.000312741 0.008736497 11.54033144 9.627975704 6 Igfals ENSMUSG00000046070.7 177.1818921 -1.281374139 0.313170749 -4.091615009 4.28E-05 0.001727681 8.380845485 7.345572631 6 Igfbp5 ENSMUSG00000026185.8 257.7565707 1.571849821 0.433958359 3.622121309 0.000292197 0.008244549 7.223399686 8.90507301 6 Igfbp6 ENSMUSG00000023046.6 120.211559 1.21604148 0.354641423 3.428932437 0.00060596 0.014764544 7.025727612 7.947087476 6 Igsf10 ENSMUSG00000036334.7 606.7247726 1.058161005 0.285900939 3.701145616 0.000214628 0.006541774 8.786632002 9.840228806 6 Igtp ENSMUSG00000078853.2 968.6316608 2.480616453 0.298697323 8.304783001 1.00E-16 4.43E-14 8.295931343 10.7848213 6 Iigp1 ENSMUSG00000054072.5 1395.525422 2.064164356 0.402768224 5.124943407 2.98E-07 2.36E-05 8.653466764 11.26846035 6 Il13ra1 ENSMUSG00000017057.8 454.4162223 1.550514464 0.330943111 4.685138972 2.80E-06 0.000169914 8.068956641 9.606449512 6 Il18 ENSMUSG00000039217.5 55.01310212 1.275298626 0.400638446 3.183165862 0.001456741 0.028968352 6.44760569 7.241250541 6 Il18rap ENSMUSG00000026068.5 57.82135854 1.432737241 0.468895286 3.055559061 0.002246414 0.039870833 6.260101558 7.272325936 6 Il2ra ENSMUSG00000026770.4 107.2078184 -1.717624458 0.428637349 -4.007174039 6.14E-05 0.002327137 7.862187435 6.611365465 6 Immt ENSMUSG00000052337.8 8063.575973 -1.060851964 0.342167308 -3.100389604 0.001932662 0.035409831 13.3717046 12.23941997 6 Impdh1 ENSMUSG00000003500.7 3269.801696 -1.274879889 0.417941938 -3.050375595 0.002285553 0.040473548 12.01511582 10.62218278 6 Inhbb ENSMUSG00000037035.5 274.8432581 -1.029637108 0.318636418 -3.23138552 0.001231917 0.025474109 8.832205075 7.885035412 6 Insig1 ENSMUSG00000045294.9 5039.485108 -1.765242363 0.335732878 -5.257877559 1.46E-07 1.26E-05 12.9322899 10.95875266 Page 67 of 79 Diabetes
6 Irf7 ENSMUSG00000025498.7 701.1741065 2.637300394 0.244353778 10.79295936 3.72E-27 4.69E-24 7.936774521 10.351637 6 Irf9 ENSMUSG00000002325.8 1206.439201 1.725421785 0.231058537 7.467466064 8.18E-14 2.09E-11 9.237002523 10.93835147 6 Irgm1 ENSMUSG00000046879.5 1554.338406 2.191565117 0.289110181 7.580380282 3.45E-14 9.42E-12 9.102946936 11.39781562 6 Irgm2 ENSMUSG00000069874.5 1555.382131 2.321892128 0.266156476 8.723785972 2.69E-18 1.47E-15 9.048171572 11.4115229 6 Irs1 ENSMUSG00000055980.2 3683.437984 -0.819243206 0.215932891 -3.793971369 0.000148257 0.004795098 12.23862448 11.39329323 6 Isca2 ENSMUSG00000021241.6 387.099655 -0.859712844 0.270429904 -3.179059829 0.001477536 0.029155997 9.183333849 8.40655987 6 Isg15 ENSMUSG00000035692.6 1458.648013 3.165979828 0.343061096 9.228618074 2.74E-20 1.87E-17 8.077845147 11.41505936 6 Isg20 ENSMUSG00000039236.10 125.5957944 1.073050215 0.326166694 3.289882856 0.001002291 0.021568987 7.151652063 7.956193778 6 Isoc2a ENSMUSG00000086784.1 1027.437275 -1.407709315 0.38565875 -3.650142299 0.000262095 0.007579956 10.55529738 9.054960868 6 Itga3 ENSMUSG00000001507.9 219.2629098 1.285209581 0.35031859 3.668687927 0.000243798 0.007177391 7.484061927 8.639490675 6 Itga6 ENSMUSG00000027111.8 8508.460582 -1.603966856 0.33929053 -4.727414165 2.27E-06 0.000141245 13.61954706 11.84861398 6 Itga7 ENSMUSG00000025348.7 600.598722 -1.921200169 0.401089695 -4.789951454 1.67E-06 0.000107487 9.8923598 8.002591073 6 Itgb7 ENSMUSG00000001281.3 26.81224869 1.87163477 0.460344177 4.065729217 4.79E-05 0.001882919 5.863202374 6.806504555 6 Itgbl1 ENSMUSG00000032925.9 2203.383162 1.274279681 0.344748049 3.696263641 0.000218796 0.006631817 10.16115816 11.70066889 6 Itih4 ENSMUSG00000021922.9 298.031319 -2.626554109 0.444993647 -5.902453048 3.58E-09 4.66E-07 9.007747379 6.677430556 6 Itm2a ENSMUSG00000031239.5 118.2110697 1.100702514 0.37133761 2.96415576 0.003035146 0.049820147 7.038537169 7.913952161 6 Itpk1 ENSMUSG00000057963.2 584.6617269 -1.212431971 0.31922838 -3.798008089 0.000145864 0.004745775 9.795558896 8.6389331 6 Ivd ENSMUSG00000027332.5 5303.993141 -1.462375073 0.35202134 -4.154222791 3.26E-05 0.001368856 12.88354093 11.29560382 6 Jak3 ENSMUSG00000031805.10 666.2020286 -1.157107605 0.310817312 -3.722790079 0.000197033 0.006084657 9.964292432 8.831815176 6 Jakmip2 ENSMUSG00000024502.8 27.10816737 1.679151698 0.480100594 3.497499732 0.000469641 0.012089758 5.812363558 6.801568741 6 Jazf1 ENSMUSG00000063568.5 40.73516957 -1.547357082 0.474227664 -3.262899234 0.001102787 0.023363702 7.074090671 6.003640264 6 Jhdm1d ENSMUSG00000042599.8 2879.90557 -0.839451938 0.245508007 -3.419244642 0.000627952 0.015232491 11.89071714 11.02657338 6 Jmjd8 ENSMUSG00000025736.8 326.9001258 -1.095520317 0.267886546 -4.08949361 4.32E-05 0.001737529 9.049776088 8.083064126 6 Kank1 ENSMUSG00000032702.9 680.4986615 -1.661380027 0.346875421 -4.789558233 1.67E-06 0.000107487 10.08578103 8.464183602 6 Kcna4 ENSMUSG00000042604.5 25.49795715 1.531064847 0.458783032 3.337230764 0.000846177 0.01903375 5.952758144 6.73572756 6 Kcnh4 ENSMUSG00000035355.8 32.48127043 -1.433354033 0.47694925 -3.00525482 0.002653584 0.045279372 6.890680515 5.963770351 6 Kcnj2 ENSMUSG00000041695.2 14.54576803 1.895341559 0.481680142 3.934855091 8.32E-05 0.003053876 5.292968574 6.444094991 6 Kcnk3 ENSMUSG00000049265.6 944.4858155 -1.407754998 0.426190269 -3.303113891 0.000956175 0.020850219 10.31359989 8.859630895 6 Kcnma1 ENSMUSG00000063142.6 44.75582247 -1.269627132 0.426544902 -2.976538051 0.002915229 0.048581225 7.065373303 6.321952233 6 Kcnt2 ENSMUSG00000052726.9 117.7241177 2.171327895 0.441117294 4.922336818 8.55E-07 5.82E-05 6.33820863 8.124741834 6 Kctd12b ENSMUSG00000041633.8 612.4096405 -1.205488443 0.288079101 -4.184574438 2.86E-05 0.001226419 9.872599842 8.721792543 6 Kif20b ENSMUSG00000024795.9 354.9920096 1.020626289 0.325133994 3.139094366 0.001694709 0.032126974 8.149913964 9.147733583 6 Kif21a ENSMUSG00000022629.9 598.1385719 -0.953623083 0.274276306 -3.47687008 0.000507304 0.01281205 9.768547752 8.8631861 6 Klf15 ENSMUSG00000030087.5 617.1789876 -2.072146068 0.428061286 -4.84076962 1.29E-06 8.59E-05 9.954937924 7.74677779 6 Klhdc8b ENSMUSG00000032609.7 98.67840374 -1.247999708 0.336011269 -3.714160275 0.00020388 0.006260706 7.752427794 6.8870649 6 Klhl5 ENSMUSG00000054920.5 2154.061846 -0.888999812 0.255167548 -3.483984611 0.000494008 0.012578791 11.49968669 10.58582367 6 Klra2 ENSMUSG00000030187.9 85.57282663 -1.888144332 0.402285362 -4.693544704 2.69E-06 0.000164293 7.724486547 6.439756277 6 Krt36 ENSMUSG00000020916.8 48.17544334 -1.760979982 0.441722135 -3.986623812 6.70E-05 0.002514866 7.21712551 6.125780619 6 Lama5 ENSMUSG00000015647.8 177.7297415 1.64603706 0.307915058 5.345750456 9.00E-08 8.34E-06 7.175265339 8.458939728 6 Lamb3 ENSMUSG00000026639.11 186.2006523 -1.633173941 0.478217048 -3.41513116 0.000637513 0.015350865 8.181365796 6.76639034 6 Lars2 ENSMUSG00000035202.7 725.0563676 -0.809003007 0.266209758 -3.038968272 0.002373899 0.041588876 9.975281847 9.194645412 6 Lcn2 ENSMUSG00000026822.9 611.3172309 -2.379395114 0.369030639 -6.447689875 1.14E-10 1.84E-08 10.14679875 7.690342806 6 Lctl ENSMUSG00000032401.9 150.857701 -1.78332428 0.471907718 -3.77896824 0.00015748 0.00504365 8.138513078 6.550770514 6 Ldhb ENSMUSG00000030246.5 3657.014133 -1.878983424 0.328422229 -5.721243135 1.06E-08 1.23E-06 12.50312613 10.43513036 6 Lef1 ENSMUSG00000027985.8 426.5788052 -1.127657444 0.281960215 -3.999349501 6.35E-05 0.002394365 9.38735676 8.352163031 6 Lep ENSMUSG00000059201.6 125.5445965 -1.698338313 0.473068305 -3.590048823 0.000330616 0.009128782 7.913472127 6.505613531 6 Letm1 ENSMUSG00000005299.5 2964.545089 -1.144227193 0.348676429 -3.281630467 0.001032088 0.022152059 11.9670515 10.76398782 6 Lfng ENSMUSG00000029570.1 908.3620486 -1.703199487 0.311981259 -5.459300631 4.78E-08 4.64E-06 10.51264938 8.822680246 6 Lgals12 ENSMUSG00000024972.9 1298.351791 -2.627587356 0.364747752 -7.203847976 5.85E-13 1.33E-10 11.14680042 8.342185516 6 Lgals3bp ENSMUSG00000033880.5 7798.457567 1.316380722 0.229619591 5.732876336 9.87E-09 1.16E-06 12.09175891 13.46897544 6 Lgals9 ENSMUSG00000001123.9 2521.926815 1.735667356 0.253382045 6.850001382 7.38E-12 1.44E-09 10.16385453 11.97987196 6 Lias ENSMUSG00000029199.5 1319.256361 -1.037497449 0.287396374 -3.609987952 0.000306211 0.008583336 10.8532809 9.808072661 6 Lipe ENSMUSG00000003123.9 9790.926431 -1.857393531 0.357505146 -5.195431596 2.04E-07 1.71E-05 13.85806232 11.76885923 6 Lpcat3 ENSMUSG00000004270.7 5138.41334 -1.013877806 0.302406371 -3.352699887 0.000800274 0.018194607 12.74883373 11.67808822 6 Lpgat1 ENSMUSG00000026623.10 7281.224679 -1.110513631 0.303038171 -3.664599839 0.000247726 0.007279936 13.27621797 12.0983162 6 Lpin1 ENSMUSG00000020593.7 5110.337429 -1.600931792 0.405858021 -3.944561179 7.99E-05 0.002952609 12.7870227 10.94668839 6 Lpl ENSMUSG00000015568.8 137740.4585 -1.796916186 0.34919623 -5.145863654 2.66E-07 2.14E-05 17.65230275 15.6413451 6 Lrg1 ENSMUSG00000037095.7 108.6993834 -1.853798862 0.440873919 -4.204827693 2.61E-05 0.001130472 7.905155551 6.499092803 6 Lrig1 ENSMUSG00000030029.7 13306.72849 -1.448804049 0.310221153 -4.670229728 3.01E-06 0.00018205 14.26578218 12.64495224 6 Lrrc32 ENSMUSG00000090958.1 86.7024816 1.124617693 0.373926007 3.007594205 0.002633245 0.044979115 6.822860104 7.592672731 6 Lrrc39 ENSMUSG00000027961.5 314.5227503 -1.386046354 0.400002203 -3.465096799 0.000530041 0.013169101 8.998797841 7.723401277 6 Lrrc58 ENSMUSG00000034158.8 7671.851752 -0.889250529 0.286476702 -3.104093712 0.001908629 0.035126479 13.28547035 12.3493655 6 Lrrc8d ENSMUSG00000046079.10 1503.597841 -1.615182565 0.349913442 -4.615948896 3.91E-06 0.000229985 11.15424667 9.459526467 6 Lrtm1 ENSMUSG00000045776.2 85.1512684 -1.829240066 0.475147514 -3.849836128 0.000118197 0.004012821 7.614526655 6.20258564 6 Ltc4s ENSMUSG00000020377.8 298.5713065 -1.789366574 0.390301109 -4.584579779 4.55E-06 0.000262657 9.037990254 7.425845975 6 Lum ENSMUSG00000036446.4 2443.534494 -1.066325307 0.263943091 -4.039981886 5.35E-05 0.00206736 11.73165481 10.63347875 6 Ly6a ENSMUSG00000075602.4 838.6865405 1.969217648 0.310521895 6.341638649 2.27E-10 3.52E-08 8.49071452 10.50891947 6 Ly6c1 ENSMUSG00000079018.3 412.069706 1.605743426 0.336433666 4.772838117 1.82E-06 0.000114564 7.91890451 9.49600353 6 Ly6c2 ENSMUSG00000022584.8 146.6915409 1.346680088 0.376916391 3.572888094 0.000353066 0.009585382 7.07189664 8.204507214 6 Ly6e ENSMUSG00000022587.7 3076.425671 1.383953409 0.221876983 6.237480754 4.45E-10 6.69E-08 10.74288314 12.1642445 6 Ly6h ENSMUSG00000022577.9 108.8246797 -1.76858012 0.415614857 -4.255334211 2.09E-05 0.000942939 7.9512866 6.588847783 6 Ly6i ENSMUSG00000022586.5 29.411028 1.517581835 0.447750994 3.389343306 0.000700602 0.01643559 6.029744665 6.820974903 6 Lyrm5 ENSMUSG00000040370.7 1357.232038 -1.059231805 0.332918473 -3.181655246 0.00146436 0.029070918 10.86463919 9.795810444 6 Mapk6 ENSMUSG00000042688.10 4705.472468 -1.136584842 0.287426429 -3.954350496 7.67E-05 0.002853581 12.67460006 11.47271635 6 Mc1r ENSMUSG00000074037.2 36.8253921 -1.397950832 0.454753241 -3.074086571 0.002111482 0.038049984 6.938976639 6.13941292 6 Mc2r ENSMUSG00000045569.6 248.8364072 -1.840869653 0.426116774 -4.32010605 1.56E-05 0.000741257 8.835685686 7.098968377 6 Mcam ENSMUSG00000032135.8 2511.536899 -1.688615905 0.289150337 -5.839923696 5.22E-09 6.54E-07 11.94096964 10.16450533 6 Mccc1 ENSMUSG00000027709.3 3306.276642 -1.138202683 0.33491192 -3.398513503 0.000677531 0.016078374 12.13398566 10.93729766 6 Mcoln2 ENSMUSG00000011008.7 40.81210628 -1.420205444 0.447397695 -3.17436916 0.001501626 0.029454137 7.01853048 6.188328727 6 Mcph1 ENSMUSG00000039842.9 900.0362468 -0.943830136 0.306406869 -3.08031651 0.002067807 0.037467296 10.29606991 9.357529933 6 Mctp1 ENSMUSG00000021596.9 46.36644885 2.249893325 0.445822285 5.046614761 4.50E-07 3.37E-05 5.933192258 7.250133408 6 Mdh1 ENSMUSG00000020321.9 9671.453161 -1.28509914 0.344633691 -3.728884241 0.000192329 0.005967281 13.70307181 12.30624933 6 Mdh2 ENSMUSG00000019179.6 10646.2605 -1.134315201 0.340288052 -3.333397086 0.000857924 0.019218905 13.79494882 12.5783135 6 Met ENSMUSG00000009376.8 2191.9914 -1.083612885 0.309895045 -3.496709296 0.000471035 0.012106629 11.58263471 10.41766603 6 Mgst1 ENSMUSG00000008540.5 11582.55018 -1.060706881 0.21938171 -4.834983191 1.33E-06 8.80E-05 13.95875208 12.84803284 6 Mgst3 ENSMUSG00000026688.5 2553.056747 -1.206569683 0.283632502 -4.253989497 2.10E-05 0.000946017 11.84405416 10.56310984 Diabetes Page 68 of 79
6 Mid2 ENSMUSG00000000266.5 330.2363318 1.713257714 0.310632064 5.515392366 3.48E-08 3.52E-06 7.695764972 9.202490219 6 Mlph ENSMUSG00000026303.6 51.04037929 -1.612161307 0.399343477 -4.037029271 5.41E-05 0.002088616 7.235250637 6.292276243 6 Mmab ENSMUSG00000029575.10 1585.908926 -0.952531614 0.280557667 -3.395136644 0.000685944 0.016207641 11.08651274 10.11232524 6 Mmd ENSMUSG00000003948.9 7942.17268 -1.841674124 0.338052958 -5.447886435 5.10E-08 4.92E-06 13.59949041 11.5159125 6 Mmp9 ENSMUSG00000017737.2 1021.246614 1.548352419 0.301805899 5.130292102 2.89E-07 2.30E-05 9.057715769 10.68497567 6 Mnda ENSMUSG00000026536.8 871.2910182 1.218311083 0.236675854 5.147593473 2.64E-07 2.14E-05 9.17536592 10.3626604 6 Mndal ENSMUSG00000090272.1 706.1722307 2.053041448 0.246437196 8.33089113 8.02E-17 3.65E-14 8.343719118 10.27347077 6 Mocs1 ENSMUSG00000064120.7 1789.226833 -0.972588878 0.301457149 -3.226292294 0.001254052 0.0258666 11.25224398 10.24458302 6 Mrap ENSMUSG00000039956.2 2064.964611 -1.520952497 0.428399437 -3.550313949 0.000384772 0.010309626 11.50013038 9.634960829 6 Mrpl12 ENSMUSG00000039640.7 1618.503077 -0.986649869 0.325387373 -3.032231583 0.002427529 0.042257556 11.09446851 10.085777 6 Mrpl41 ENSMUSG00000036850.3 373.2073694 -1.124538249 0.271887042 -4.136049452 3.53E-05 0.001466837 9.218970898 8.211327697 6 Ms4a4d ENSMUSG00000024678.6 18.06500464 1.775382136 0.481918405 3.683989067 0.000229612 0.006908586 5.694911074 6.570747241 6 Msln ENSMUSG00000063011.6 273.8311261 1.526083128 0.44304524 3.444531143 0.000572051 0.014105997 7.261723768 8.956132771 6 Mst1 ENSMUSG00000032591.9 39.83630947 -1.690457349 0.486332774 -3.475927262 0.00050909 0.012823446 6.919686293 5.858946647 6 Mtap1b ENSMUSG00000052727.4 580.9342722 1.774417621 0.289374133 6.131915112 8.68E-10 1.25E-07 8.257651416 9.966569629 6 Mtap7d2 ENSMUSG00000041020.7 143.4759628 -1.079869592 0.340407681 -3.17228327 0.001512454 0.029525263 8.106004198 7.235453125 6 Mthfd1l ENSMUSG00000040675.11 756.8616852 0.916230365 0.236017267 3.882048026 0.00010358 0.003598542 9.193211759 10.07785918 6 Mtss1 ENSMUSG00000022353.8 60.25958857 -1.516300639 0.477775019 -3.173670822 0.001505243 0.029454623 7.22803699 6.223082419 6 Mut ENSMUSG00000023921.7 3091.403184 -1.238604959 0.369706499 -3.350238536 0.00080742 0.018298358 12.0268259 10.70995432 6 Mx1 ENSMUSG00000000386.8 677.6426857 3.618239757 0.333581662 10.84663867 2.07E-27 2.83E-24 7.061889847 10.41176035 6 Mx2 ENSMUSG00000023341.8 596.0956103 3.029589363 0.322193055 9.403025049 5.30E-21 4.35E-18 7.363834912 10.18586753 6 Mxd1 ENSMUSG00000001156.7 950.1421731 -1.170090867 0.318530632 -3.673401398 0.000239343 0.007072061 10.4295324 9.263826602 6 Mybbp1a ENSMUSG00000040463.9 5189.964673 0.661098273 0.2191855 3.016158792 0.002559992 0.044234712 11.97748367 12.66562477 6 Myo19 ENSMUSG00000020527.8 648.8108886 -1.00221606 0.305983132 -3.275396438 0.001055138 0.022528843 9.8786948 8.911153562 6 Myo1e ENSMUSG00000032220.8 689.8589904 1.04565045 0.308355911 3.391050447 0.000696253 0.016403957 8.930115897 10.0018483 6 Myo7a ENSMUSG00000030761.9 763.3142414 1.149435113 0.253814655 4.528639666 5.94E-06 0.000321274 9.04089625 10.16686121 6 N4bp2l1 ENSMUSG00000041132.8 533.1064927 -1.685183804 0.41013084 -4.108893167 3.98E-05 0.001621688 9.666923319 8.041184393 6 Naaa ENSMUSG00000029413.7 3839.909434 -1.276426783 0.278255243 -4.587251505 4.49E-06 0.000260235 12.43124207 11.09150988 6 Naip1 ENSMUSG00000021640.5 91.63193603 1.285053899 0.378692117 3.393400186 0.000690307 0.016287275 6.767421322 7.701483278 6 Naip2 ENSMUSG00000078945.3 434.0756491 1.101579617 0.278613542 3.953790654 7.69E-05 0.002853798 8.380982487 9.411905171 6 Naip3 ENSMUSG00000082956.3 87.40162425 1.180882168 0.376044705 3.1402707 0.001687918 0.032064607 6.787669802 7.628878189 6 Naip5 ENSMUSG00000071203.5 206.0699806 1.52696803 0.294866415 5.178507794 2.24E-07 1.85E-05 7.372682249 8.605518543 6 Naip6 ENSMUSG00000078942.3 151.8090014 1.212526048 0.342088237 3.544483316 0.000393383 0.010506028 7.218730851 8.19990614 6 Napepld ENSMUSG00000044968.9 553.0394873 -1.388589425 0.309076315 -4.492707331 7.03E-06 0.000373192 9.786767718 8.455884443 6 Nat8l ENSMUSG00000048142.8 705.1970577 -2.232120685 0.441695916 -5.053523491 4.34E-07 3.26E-05 10.18320361 7.60583683 6 Nav3 ENSMUSG00000020181.9 470.9324795 -1.293263359 0.323522192 -3.997448678 6.40E-05 0.002408132 9.541165421 8.326745284 6 Ndn ENSMUSG00000033585.4 1785.106953 1.528775902 0.277766864 5.503809484 3.72E-08 3.74E-06 9.827633751 11.44986753 6 Ndrg1 ENSMUSG00000005125.6 228.9404569 0.996277684 0.282233747 3.529973634 0.000415601 0.010974278 7.762104735 8.592801005 6 Ndrg2 ENSMUSG00000004558.8 125.2895563 -2.18525304 0.426852353 -5.119458814 3.06E-07 2.42E-05 8.113583972 6.4589615 6 Ndufa1 ENSMUSG00000016427.7 918.5701422 -0.809763936 0.271125689 -2.986673593 0.002820307 0.047288438 10.29187905 9.492723605 6 Ndufa4 ENSMUSG00000029632.5 3664.692959 -0.763284907 0.240765465 -3.170242495 0.001523118 0.029612816 12.20443371 11.41551415 6 Ndufa9 ENSMUSG00000000399.7 3590.390091 -0.997132797 0.312575995 -3.190049176 0.001422486 0.028446248 12.22535575 11.18103189 6 Ndufb3 ENSMUSG00000026032.8 984.6293485 -0.877371666 0.289949221 -3.025949383 0.002478538 0.043008534 10.40047205 9.530186433 6 Ndufs1 ENSMUSG00000025968.9 3993.820091 -1.125649071 0.360604745 -3.121559232 0.001798961 0.033560131 12.36880032 11.17250125 6 Net1 ENSMUSG00000021215.8 4172.286084 -0.914913861 0.258813738 -3.535028192 0.000407732 0.010801266 12.44616141 11.47898204 6 Nfkbie ENSMUSG00000023947.7 317.2784132 1.37735229 0.331509428 4.154790707 3.26E-05 0.001368856 7.812813013 9.103136101 6 Nhsl1 ENSMUSG00000039835.9 147.7772897 1.881478912 0.318559525 5.906208313 3.50E-09 4.59E-07 6.905423999 8.297177833 6 Niacr1 ENSMUSG00000045502.4 407.3502 -2.321053166 0.443739376 -5.230667577 1.69E-07 1.44E-05 9.560866778 7.01283308 6 Nmi ENSMUSG00000026946.3 296.8576001 1.044019464 0.276658285 3.773678655 0.000160858 0.005131806 8.00451611 8.916282908 6 Nnmt ENSMUSG00000032271.7 1518.611356 -0.946241876 0.224031645 -4.223697394 2.40E-05 0.001050901 11.03831535 10.08769841 6 Nod1 ENSMUSG00000038058.8 946.5910467 -0.887081493 0.241157906 -3.678425925 0.000234678 0.007009557 10.3707997 9.492553631 6 Nov ENSMUSG00000037362.8 135.3409766 2.129091518 0.364079256 5.847879229 4.98E-09 6.28E-07 6.657941254 8.252362783 6 Npm1 ENSMUSG00000057113.7 12432.94535 0.690522173 0.223776021 3.085773759 0.002030232 0.03686794 13.19795518 13.92901243 6 Npy1r ENSMUSG00000036437.5 282.8131238 1.712189562 0.355779619 4.812500405 1.49E-06 9.70E-05 7.474642194 9.012709726 6 Nr1h3 ENSMUSG00000002108.4 1449.317511 -1.617838475 0.363212734 -4.454244917 8.42E-06 0.000431416 11.11346591 9.360616425 6 Nrg4 ENSMUSG00000032311.10 194.9462498 -1.671708092 0.462429588 -3.615054347 0.000300285 0.008431622 8.340589095 6.913031867 6 Nrip1 ENSMUSG00000048490.7 2979.177024 -1.50363857 0.326959469 -4.598853112 4.25E-06 0.000247909 12.10016539 10.50717987 6 Nrn1 ENSMUSG00000039114.9 2665.166126 -1.236695354 0.329791732 -3.749928316 0.000176885 0.005570151 11.87983825 10.55492894 6 Nsdhl ENSMUSG00000031349.4 1976.632983 -0.914416615 0.279005912 -3.277409456 0.001047643 0.022427225 11.3939318 10.42436138 6 Nsun7 ENSMUSG00000029206.7 80.79123016 -1.142022152 0.371405352 -3.074867244 0.002105963 0.038049984 7.544402849 6.761833271 6 Ntn3 ENSMUSG00000079662.1 245.8474654 -1.31869518 0.278606628 -4.733179502 2.21E-06 0.000137812 8.7640906 7.660276973 6 Nudt12 ENSMUSG00000024228.6 467.8162587 -1.097340148 0.352669068 -3.111529331 0.00186121 0.03448601 9.447518518 8.425780362 6 Nup107 ENSMUSG00000052798.6 3463.593739 1.668541292 0.236057238 7.068375886 1.57E-12 3.30E-10 10.67182008 12.40982332 6 O3far1 ENSMUSG00000054200.6 53.19222131 -2.319047524 0.484915218 -4.782377285 1.73E-06 0.000110408 7.22507181 5.683425213 6 Oas1a ENSMUSG00000052776.9 249.6966179 5.080051423 0.366523074 13.86011356 1.10E-43 6.04E-40 5.838033633 9.150319291 6 Oas1b ENSMUSG00000029605.8 195.7024558 2.054130867 0.321966362 6.379954885 1.77E-10 2.79E-08 7.019977259 8.650074217 6 Oas1c ENSMUSG00000001166.10 69.42674055 1.355196436 0.38600125 3.510860229 0.000446659 0.011681527 6.572543921 7.44360663 6 Oas1g ENSMUSG00000066861.7 169.1918361 4.719747578 0.390504431 12.0862843 1.25E-33 4.09E-30 5.74794402 8.671198365 6 Oas2 ENSMUSG00000032690.9 482.7896599 4.31107358 0.295716746 14.57838842 3.86E-48 3.16E-44 6.562937461 9.979292344 6 Oas3 ENSMUSG00000032661.8 32.25740799 1.632866261 0.447305956 3.650446055 0.000261785 0.007579956 6.028143477 6.894796595 6 Oasl2 ENSMUSG00000029561.10 2629.474666 3.796960683 0.246304047 15.41574623 1.28E-53 2.10E-49 8.520057815 12.29460108 6 Obfc2a ENSMUSG00000026107.5 7236.30902 -1.766708981 0.333575206 -5.296283863 1.18E-07 1.05E-05 13.41515547 11.5015328 6 Odf3l1 ENSMUSG00000045620.6 64.92395238 -1.443829674 0.486449457 -2.968098027 0.002996488 0.049333737 7.231511745 6.111172201 6 Odz3 ENSMUSG00000031561.8 13.04446972 1.470664919 0.483333995 3.042750836 0.002344263 0.041187177 5.500091573 6.389680458 6 Ogfr ENSMUSG00000049401.9 3378.218825 0.729704946 0.216278481 3.373913773 0.000741076 0.017135117 11.33065787 12.08231227 6 Ogn ENSMUSG00000021390.5 5468.477372 0.951153756 0.26093305 3.645202302 0.000267182 0.007713456 11.84106473 12.83539652 6 Olr1 ENSMUSG00000030162.7 410.8461226 -3.035800301 0.382325482 -7.940355638 2.02E-15 7.03E-13 9.604172061 6.917365712 6 Oplah ENSMUSG00000022562.7 508.8154899 -1.105385011 0.371709618 -2.973786416 0.002941497 0.048771158 9.532529234 8.497146619 6 Orm1 ENSMUSG00000039196.2 1847.620364 -1.562806043 0.358468641 -4.35967297 1.30E-05 0.00063025 11.41982341 9.752738872 6 Orm2 ENSMUSG00000061540.3 559.3261729 -1.289732525 0.405589978 -3.179892487 0.001473297 0.029139917 9.692687816 8.375802197 6 Ormdl3 ENSMUSG00000038150.7 3632.878301 -0.85992541 0.277569631 -3.098052936 0.001947966 0.035574794 12.21293938 11.32255 6 Ostn ENSMUSG00000052276.8 55.77170696 2.057057391 0.404585565 5.084356859 3.69E-07 2.83E-05 6.1712111 7.368787398 6 Pank3 ENSMUSG00000018846.8 15377.90499 -1.501965523 0.322038263 -4.663934988 3.10E-06 0.000186336 14.44981425 12.81739154 6 Paqr4 ENSMUSG00000023909.3 2419.854218 -1.53739434 0.295765342 -5.198020605 2.01E-07 1.69E-05 11.84468628 10.23175761 6 Parm1 ENSMUSG00000034981.9 2517.435411 -2.199578628 0.314939314 -6.984134819 2.87E-12 5.80E-10 12.03650591 9.687390442 6 Parp12 ENSMUSG00000038507.6 2083.65059 1.03942487 0.220167575 4.721062434 2.35E-06 0.000145179 10.45484272 11.51110073 Page 69 of 79 Diabetes
6 Parp14 ENSMUSG00000034422.8 2022.98065 2.23325516 0.28075115 7.954571733 1.80E-15 6.41E-13 9.419816024 11.77300958 6 Parp9 ENSMUSG00000022906.8 1608.043888 1.309053239 0.241317837 5.42460207 5.81E-08 5.54E-06 9.901934662 11.23272934 6 Pcca ENSMUSG00000041650.8 1398.523219 -1.0011058 0.309594815 -3.233600017 0.001222405 0.025339871 10.90597107 9.897455166 6 Pccb ENSMUSG00000032527.6 1600.346856 -1.037936537 0.340886991 -3.044811224 0.002328264 0.041008456 11.07853649 10.02031543 6 Pcdh9 ENSMUSG00000055421.2 89.70187697 1.142144362 0.381362426 2.994905327 0.0027453 0.046409727 6.82042422 7.637923383 6 Pcx ENSMUSG00000024892.8 29087.27612 -1.791944644 0.36326704 -4.932857786 8.10E-07 5.54E-05 15.42746882 13.33851785 6 Pde1c ENSMUSG00000004347.9 9.80966858 1.734714438 0.479032857 3.621284872 0.000293144 0.008245227 5.292968574 6.292276243 6 Pde3b ENSMUSG00000030671.8 1549.561481 -1.371822125 0.385226659 -3.561077856 0.000369336 0.009944769 11.05992004 9.651113614 6 Pdhb ENSMUSG00000021748.8 4437.737518 -1.320419569 0.383659849 -3.441641264 0.000578196 0.014193512 12.54839994 11.09894659 6 Pdhx ENSMUSG00000010914.4 1751.436251 -1.27253073 0.356765118 -3.566858598 0.000361286 0.009760087 11.27384375 9.922403596 6 Pdia4 ENSMUSG00000025823.8 10565.39582 -1.193860244 0.368756076 -3.237533755 0.001205677 0.025155386 13.74962095 12.48776245 6 Pdpn ENSMUSG00000028583.8 589.4928221 1.045962807 0.305427995 3.424580661 0.000615749 0.01498079 8.740220483 9.798196233 6 Pdzd2 ENSMUSG00000022197.8 1308.333885 -2.350210476 0.258307114 -9.098512392 9.16E-20 5.56E-17 11.16933066 8.829614642 6 Pdzk1 ENSMUSG00000038298.8 67.73389242 -2.166392351 0.429866664 -5.039684468 4.66E-07 3.48E-05 7.535079465 6.159592066 6 Peg10 ENSMUSG00000092035.1 4857.863893 -1.761142598 0.387753277 -4.54191545 5.57E-06 0.000307782 12.75894305 10.81790029 6 Peli2 ENSMUSG00000021846.7 1970.581536 -0.811446353 0.225395889 -3.600093851 0.000318102 0.008856099 11.3529412 10.52859797 6 Pemt ENSMUSG00000000301.9 217.8953977 -1.347219709 0.341987638 -3.939381308 8.17E-05 0.003010304 8.624662087 7.469657387 6 Pex11a ENSMUSG00000030545.7 1449.939109 -1.685086494 0.352515382 -4.78017862 1.75E-06 0.000110886 11.12272679 9.344658642 6 Pex11c ENSMUSG00000069633.6 403.4836563 -1.001139911 0.332860645 -3.007684822 0.00263246 0.044979115 9.254858932 8.331882409 6 Pex16 ENSMUSG00000027222.8 1135.901902 -1.293813531 0.335909047 -3.85167813 0.000117311 0.003991013 10.70963952 9.367238321 6 Pex19 ENSMUSG00000003464.7 3622.39589 -1.024927422 0.311438404 -3.290947453 0.000998506 0.021544073 12.2548358 11.16717717 6 Pfkfb1 ENSMUSG00000025271.7 595.0355759 -1.604787367 0.37710999 -4.255488877 2.09E-05 0.000942939 9.889695164 8.275805158 6 Pfkfb3 ENSMUSG00000026773.10 2118.717848 -1.866506598 0.326019649 -5.725135296 1.03E-08 1.21E-06 11.71724053 9.733119491 6 Pgm5 ENSMUSG00000041731.7 151.0542565 1.255968778 0.309295285 4.060743373 4.89E-05 0.001909848 7.232886264 8.192812992 6 Phf11 ENSMUSG00000044703.5 96.03247894 2.153249025 0.361801224 5.951469712 2.66E-09 3.54E-07 6.459286088 7.885960536 6 Phtf2 ENSMUSG00000039987.9 827.3475899 -1.094000841 0.329213768 -3.323071356 0.000890321 0.019836263 10.21365375 9.131935159 6 Pik3r5 ENSMUSG00000020901.7 160.3512495 1.194841745 0.373627079 3.19795275 0.00138407 0.02788203 7.227741173 8.263261397 6 Pim3 ENSMUSG00000035828.9 1911.021684 -1.362395719 0.333909671 -4.080132554 4.50E-05 0.001800182 11.45253603 9.993738813 6 Pkia ENSMUSG00000027499.7 344.4030614 1.123686188 0.294397412 3.816902399 0.000135138 0.004449772 8.101507197 9.123702444 6 Pkp4 ENSMUSG00000026991.11 1013.738186 0.915406422 0.27637129 3.312234138 0.00092554 0.020438881 9.529566393 10.48160844 6 Pla1a ENSMUSG00000002847.6 25.20001031 1.449214702 0.468439259 3.093708896 0.001976713 0.035975745 5.952758144 6.708873967 6 Pla2g16 ENSMUSG00000060675.7 3711.012395 -1.495409385 0.250036736 -5.980758703 2.22E-09 3.04E-07 12.45773346 10.89436437 6 Pla2g7 ENSMUSG00000023913.10 272.8606961 1.18170073 0.322554994 3.663563582 0.00024873 0.007296389 7.793747815 8.861955796 6 Plac8 ENSMUSG00000029322.6 2829.808268 1.120849058 0.36617586 3.060958356 0.002206298 0.039374274 10.5703069 11.99997453 6 Plcb1 ENSMUSG00000051177.9 1941.933231 -0.806336729 0.253668884 -3.178697819 0.001479382 0.029157345 11.32427906 10.50099407 6 Plcb2 ENSMUSG00000040061.11 183.8062772 -2.16870068 0.45083151 -4.810446101 1.51E-06 9.76E-05 8.469745011 6.585521497 6 Plekha2 ENSMUSG00000031557.9 574.1623006 0.827979825 0.25724501 3.218642898 0.001287988 0.026334693 8.890318129 9.685202634 6 Plekho2 ENSMUSG00000050721.8 1323.306187 0.783666654 0.240906132 3.252995873 0.001141952 0.024007335 9.996911769 10.79317195 6 Plin1 ENSMUSG00000030546.7 9698.25432 -1.787402076 0.352050052 -5.077124878 3.83E-07 2.92E-05 13.85476019 11.81822845 6 Plin4 ENSMUSG00000002831.7 16974.99769 -1.782058379 0.354539325 -5.026405399 5.00E-07 3.67E-05 14.6178368 12.64646398 6 Plk2 ENSMUSG00000021701.7 1305.087787 1.113961753 0.233955116 4.761433605 1.92E-06 0.000120769 9.766923945 10.88500922 6 Plp2 ENSMUSG00000031146.6 2501.363833 0.889727269 0.227958016 3.903031295 9.50E-05 0.003379034 10.80291793 11.71620643 6 Plscr2 ENSMUSG00000032372.7 87.25234927 1.590952511 0.352262505 4.516383343 6.29E-06 0.000337095 6.64618834 7.702946213 6 Pml ENSMUSG00000036986.9 1568.266758 1.093694697 0.261820421 4.177270411 2.95E-05 0.00125552 9.99756857 11.13900817 6 Pmpcb ENSMUSG00000029017.7 3130.302607 -0.961910445 0.282991748 -3.399075951 0.000676139 0.016068599 12.03858671 11.03714755 6 Pnpla2 ENSMUSG00000025509.8 21237.58082 -1.626289973 0.394291319 -4.124589851 3.71E-05 0.001530189 14.90641446 12.9286083 6 Pnpla3 ENSMUSG00000041653.4 858.9011167 -1.335727415 0.411720893 -3.244254635 0.001177584 0.024724746 10.24024268 8.830797792 6 Pnpla8 ENSMUSG00000036257.8 2953.500841 -1.222934732 0.327963796 -3.728871129 0.000192339 0.005967281 12.00491117 10.72557173 6 Poln ENSMUSG00000045102.7 398.6360632 -1.695221546 0.385903233 -4.392866922 1.12E-05 0.000554191 9.384171444 7.769695481 6 Pon2 ENSMUSG00000032667.10 1421.056769 -1.171300378 0.32176926 -3.640187313 0.00027244 0.007823936 10.97381659 9.783848224 6 Por ENSMUSG00000005514.8 3749.016551 -1.173933953 0.338104408 -3.472104842 0.000516395 0.012980664 12.3263149 11.07296064 6 Ppa1 ENSMUSG00000020089.7 2637.578046 -1.39449917 0.438942762 -3.176949913 0.001488327 0.0292633 11.65547896 10.12771405 6 Ppapdc2 ENSMUSG00000040105.2 763.9497836 -1.214748082 0.398716196 -3.046648452 0.002314082 0.040890424 10.04937161 8.848158558 6 Pparg ENSMUSG00000000440.6 4526.103967 -1.695132301 0.369922218 -4.582401975 4.60E-06 0.000264477 12.7149085 10.80033775 6 Ppargc1b ENSMUSG00000033871.8 391.5453812 -1.870526979 0.429767705 -4.352414003 1.35E-05 0.000647489 9.327333265 7.47759953 6 Ppef1 ENSMUSG00000062168.6 366.2059348 2.662168953 0.331063535 8.041262983 8.89E-16 3.26E-13 7.153986157 9.511351142 6 Ppip5k1 ENSMUSG00000033526.9 1498.024256 -1.143422114 0.339715018 -3.365827394 0.000763144 0.017502158 11.01927762 9.85723835 6 Ppm1k ENSMUSG00000037826.3 414.4286412 -0.94968855 0.319771833 -2.969894323 0.002979022 0.049185765 9.27518447 8.408175232 6 Ppp1r12b ENSMUSG00000073557.4 1452.506318 0.905278119 0.284717269 3.17956871 0.001474944 0.029139917 10.01644831 10.95508465 6 Preb ENSMUSG00000045302.7 2221.438696 -0.701687423 0.235899588 -2.974517377 0.002934498 0.04872308 11.47730239 10.76022636 6 Prelp ENSMUSG00000041577.5 4505.538061 -1.055142063 0.23530407 -4.484164104 7.32E-06 0.000383495 12.60905705 11.50081494 6 Prkar2b ENSMUSG00000002997.9 4821.638086 -1.170833476 0.319936772 -3.659577695 0.000252631 0.007381479 12.69089366 11.45695211 6 Prkd1 ENSMUSG00000002688.7 69.72981299 3.260694618 0.419911874 7.765187927 8.15E-15 2.52E-12 5.84098459 7.664807695 6 Prlr ENSMUSG00000005268.13 371.8313863 -1.380860771 0.323132696 -4.273355156 1.93E-05 0.000886936 9.263630812 8.014551864 6 Prps1 ENSMUSG00000031432.3 1569.538806 -1.101201357 0.288807455 -3.812925666 0.000137331 0.004494932 11.13075766 9.975827177 6 Prps2 ENSMUSG00000025742.5 1409.280014 0.830325128 0.275896438 3.009553638 0.002616319 0.044876983 10.0179668 10.90448712 6 Prune2 ENSMUSG00000039126.8 3555.106564 1.262106534 0.319001921 3.956422988 7.61E-05 0.002835378 10.91081714 12.33877378 6 Psen2 ENSMUSG00000010609.9 1262.15734 -1.289219393 0.328180913 -3.928380172 8.55E-05 0.003123287 10.84053253 9.533086577 6 Psmb10 ENSMUSG00000031897.8 1097.664372 0.98513035 0.236430227 4.166685298 3.09E-05 0.001309555 9.62551415 10.60412374 6 Psmb8 ENSMUSG00000024338.8 174.9929071 1.923139088 0.32209826 5.970659661 2.36E-09 3.20E-07 7.002400878 8.498129249 6 Ptcd3 ENSMUSG00000063884.4 2264.437611 -1.005306425 0.330681809 -3.040101991 0.00236498 0.041476951 11.57254604 10.51297594 6 Ptgs1 ENSMUSG00000047250.6 2900.303749 1.10276777 0.355155979 3.105023806 0.001902637 0.035086199 10.6533129 12.0246782 6 Ptpn4 ENSMUSG00000026384.7 684.8006389 -0.996478196 0.265930906 -3.747131962 0.000178868 0.005618922 9.963125344 9.006363861 6 Ptprj ENSMUSG00000025314.9 205.2570769 1.245045619 0.347221999 3.585733685 0.000336132 0.009217208 7.461687736 8.53710204 6 Ptprm ENSMUSG00000033278.8 579.0862555 -0.877336953 0.246866107 -3.553897958 0.000379566 0.010186793 9.708802951 8.881331779 6 Ptprq ENSMUSG00000035916.5 133.8710241 3.249067825 0.347712769 9.344114204 9.27E-21 7.24E-18 6.231232511 8.340433125 6 Pxmp4 ENSMUSG00000000876.5 2468.712707 -1.133073175 0.326929594 -3.465801796 0.000528653 0.013154551 11.74110674 10.53599902 6 Rab39b ENSMUSG00000031202.5 110.5066525 0.984261688 0.330171241 2.981064261 0.002872485 0.048043946 7.088177322 7.802801498 6 Rab3d ENSMUSG00000019066.7 566.2768478 -1.236868569 0.365254297 -3.386321751 0.000708363 0.016546628 9.728214243 8.526110062 6 Racgap1 ENSMUSG00000023015.6 1154.03063 0.855788727 0.286782942 2.984099124 0.002844146 0.047638722 9.729683887 10.63565706 6 Rad51 ENSMUSG00000027323.4 227.8720011 0.922003779 0.308625053 2.987456042 0.002813097 0.047288438 7.773093585 8.571037138 6 Raet1d ENSMUSG00000078452.2 46.79274448 1.291879572 0.404128262 3.196706819 0.001390061 0.027968375 6.360261753 7.11202451 6 Rai14 ENSMUSG00000022246.7 1924.482057 1.110174076 0.240597837 4.614231327 3.95E-06 0.000231067 10.28232281 11.42557727 6 Ralgapa2 ENSMUSG00000037110.12 4062.706156 -1.303552509 0.303112163 -4.30056154 1.70E-05 0.000793653 12.50700188 11.12404648 6 Ranbp3l ENSMUSG00000048424.8 47.68462867 -1.559384832 0.4832132 -3.227115549 0.00125045 0.025824775 7.245459254 5.956752141 6 Rarres2 ENSMUSG00000009281.4 2236.365568 -1.665446541 0.308220652 -5.403422943 6.54E-08 6.20E-06 11.76060152 10.00319859 Diabetes Page 70 of 79
6 Rasd1 ENSMUSG00000049892.7 131.031819 -2.817914019 0.372572219 -7.563403478 3.93E-14 1.06E-11 8.281134631 6.326713918 6 Rasl12 ENSMUSG00000041696.7 258.1283257 -1.131326923 0.28877173 -3.917720484 8.94E-05 0.003207487 8.770990124 7.806596457 6 Rassf2 ENSMUSG00000027339.9 1824.934107 0.790055909 0.266025895 2.969845886 0.002979492 0.049185765 10.41720147 11.23203449 6 Rassf3 ENSMUSG00000025795.7 84.96306554 -1.460374453 0.433003371 -3.372663015 0.00074445 0.017169468 7.608103077 6.577871047 6 Rassf6 ENSMUSG00000029370.7 75.98212653 -1.741204214 0.486503415 -3.579017452 0.000344888 0.009394486 7.355604507 5.996996982 6 Rb1 ENSMUSG00000022105.6 779.6385312 -1.019747698 0.329103679 -3.098560613 0.001944632 0.035574794 10.10539183 9.114701567 6 Rbm47 ENSMUSG00000070780.5 161.1621055 -2.188125105 0.453643267 -4.823448869 1.41E-06 9.29E-05 8.314597839 6.487814274 6 Rbpms2 ENSMUSG00000032387.8 308.2178768 -1.175264536 0.370123124 -3.17533399 0.001496641 0.029391526 8.942584169 7.89918031 6 Rdh12 ENSMUSG00000021123.6 72.36230667 -1.382362676 0.404232614 -3.419720796 0.000626854 0.015228382 7.497651803 6.54527876 6 Retn ENSMUSG00000012705.9 5856.321044 -2.093002938 0.430398114 -4.862946347 1.16E-06 7.80E-05 13.13142459 10.34006811 6 Retnla ENSMUSG00000061100.3 107.6620519 -1.409127465 0.35807585 -3.93527646 8.31E-05 0.003053876 7.88531546 6.842506739 6 Retsat ENSMUSG00000056666.6 3525.375045 -1.306097404 0.376743698 -3.466806247 0.000526681 0.01314539 12.22607008 10.81336322 6 Rhob ENSMUSG00000054364.4 4306.909544 -0.946912221 0.312068086 -3.03431291 0.002410842 0.042056375 12.48245905 11.45730152 6 Rilpl2 ENSMUSG00000029401.7 764.9153838 -0.882773194 0.248131644 -3.557680838 0.000374144 0.010057714 10.08238942 9.219237742 6 Rin1 ENSMUSG00000024883.6 496.4363594 1.448057503 0.260511036 5.558526518 2.72E-08 2.82E-06 8.336334662 9.67557514 6 Rnf11 ENSMUSG00000028557.4 5356.786267 -1.133721341 0.353145875 -3.210348537 0.001325741 0.026895455 12.78794842 11.59836599 6 Rnf125 ENSMUSG00000033107.4 262.6046347 -1.469487066 0.421502592 -3.486306123 0.00048974 0.01250513 8.79839895 7.426401459 6 Rnf128 ENSMUSG00000031438.5 175.4910764 -1.876372648 0.423741132 -4.428110722 9.51E-06 0.00048112 8.383844551 6.870811217 6 Rnf213 ENSMUSG00000070327.6 16788.43058 2.289425498 0.278402377 8.223440925 1.98E-16 8.11E-14 12.28111109 14.79719135 6 Rnf24 ENSMUSG00000048911.7 2500.506868 -0.778500168 0.2613149 -2.979164866 0.002890352 0.048215661 11.66288431 10.86606707 6 Robo1 ENSMUSG00000022883.9 80.51362954 2.520073244 0.374848349 6.72291409 1.78E-11 3.32E-09 6.219095652 7.751294064 6 Robo2 ENSMUSG00000052516.11 152.0300158 2.343385379 0.453104179 5.171846757 2.32E-07 1.90E-05 6.375003349 8.282132716 6 RP24-323I5.2 ENSMUSG00000092500.1 57.93721204 -1.773482779 0.435415391 -4.073082432 4.64E-05 0.001833217 7.355259826 6.224422714 6 Rpia ENSMUSG00000053604.5 837.9438376 -0.832429072 0.237654926 -3.502679644 0.000460603 0.01189444 10.18684583 9.371726685 6 Rpp14 ENSMUSG00000023156.2 956.0098751 -0.92629013 0.306156646 -3.02554311 0.00248187 0.043020833 10.37257709 9.445867816 6 Rprml ENSMUSG00000046215.2 68.77097591 -2.132222942 0.486093915 -4.386442365 1.15E-05 0.00056568 7.395376137 5.764025816 6 Rpusd3 ENSMUSG00000051169.8 383.2836729 -1.487169483 0.300235919 -4.953336323 7.30E-07 5.09E-05 9.344088039 7.995639863 6 Rreb1 ENSMUSG00000039087.9 2624.959712 -0.959101059 0.27396672 -3.50079403 0.000463874 0.011960077 11.79173321 10.80265969 6 Rsad2 ENSMUSG00000020641.8 154.8620334 3.308606912 0.411482579 8.040697426 8.93E-16 3.26E-13 6.087326758 8.527265153 6 Rspo3 ENSMUSG00000019880.9 92.03496416 1.817339328 0.466017925 3.899719798 9.63E-05 0.003410787 6.282489382 7.772542326 6 Rtn4ip1 ENSMUSG00000019864.7 291.8191755 -1.074776466 0.362411782 -2.96562231 0.003020712 0.049632902 8.854237831 7.91575672 6 Rtn4rl1 ENSMUSG00000045287.6 33.07908721 -1.518476965 0.458494481 -3.311876215 0.000926725 0.020438881 6.882891349 6.051181647 6 Rtp4 ENSMUSG00000033355.5 681.9110208 2.835942648 0.246397064 11.50964464 1.18E-30 2.76E-27 7.771672877 10.33730515 6 S100a1 ENSMUSG00000044080.9 1168.906514 -1.962985206 0.40761389 -4.815795675 1.47E-06 9.58E-05 10.84178156 8.631517326 6 S100a6 ENSMUSG00000001025.4 13022.86637 0.956632693 0.307653942 3.109443967 0.001874398 0.034652068 12.97814275 14.11516595 6 S100a8 ENSMUSG00000056054.8 73.28334038 -2.252956968 0.40546019 -5.556542976 2.75E-08 2.84E-06 7.620038932 6.223082419 6 Samd9l ENSMUSG00000047735.10 3288.64136 1.60685309 0.241284179 6.659587459 2.75E-11 4.84E-09 10.64215266 12.32288763 6 Samhd1 ENSMUSG00000027639.9 2408.363317 0.716829488 0.226995988 3.15789497 0.001589128 0.030514541 10.86357831 11.59970768 6 Sbsn ENSMUSG00000046056.7 616.5889053 -1.761137271 0.423499375 -4.158535706 3.20E-05 0.001350176 9.825773357 8.090851559 6 Scarb1 ENSMUSG00000037936.9 2933.58969 -1.57903373 0.266869693 -5.91687168 3.28E-09 4.34E-07 12.13624841 10.49467457 6 Scd3 ENSMUSG00000025202.6 6803.887639 -1.668661128 0.429373141 -3.886272731 0.000101795 0.003551567 13.12606337 11.16430881 6 Scd4 ENSMUSG00000050195.8 3118.535261 -1.769582298 0.419258953 -4.220738247 2.44E-05 0.00106196 12.08391094 10.0448333 6 Schip1 ENSMUSG00000027777.7 114.3318191 1.258139558 0.381138752 3.301001408 0.000963404 0.02095212 6.924705206 7.920691692 6 Scp2 ENSMUSG00000028603.9 8660.259862 -1.324685035 0.261723755 -5.061386333 4.16E-07 3.16E-05 13.61567005 12.20892491 6 Scp2-ps2 ENSMUSG00000058492.4 1326.693581 -1.363429427 0.254661926 -5.353880132 8.61E-08 8.02E-06 10.97603508 9.602508355 6 Scpep1 ENSMUSG00000000278.9 7498.395093 0.863068061 0.260515937 3.31291848 0.000923279 0.020438881 12.32898011 13.27656706 6 Selenbp1 ENSMUSG00000068874.7 390.3733314 -1.924372151 0.445707693 -4.317565484 1.58E-05 0.000747671 9.273048838 7.357381073 6 Selenbp2 ENSMUSG00000068877.5 238.4040448 -1.766010576 0.450662392 -3.918699692 8.90E-05 0.003201492 8.654363417 7.043980278 6 Sema3g ENSMUSG00000021904.5 546.7987843 -1.397311842 0.296806967 -4.707813485 2.50E-06 0.000153778 9.78670172 8.444560789 6 Sema4g ENSMUSG00000025207.8 182.3880505 -1.062491101 0.349990237 -3.035773539 0.002399195 0.041987191 8.329748126 7.470386306 6 Sema5a ENSMUSG00000022231.8 1024.205849 1.560752776 0.256186863 6.092243606 1.11E-09 1.56E-07 9.125197099 10.67517628 6 Sema6a ENSMUSG00000019647.9 137.9893009 2.667416646 0.354300194 7.528690906 5.13E-14 1.36E-11 6.457478131 8.325996811 6 Sema6d ENSMUSG00000027200.11 2419.658552 -1.184220733 0.274483465 -4.314360914 1.60E-05 0.000756412 11.75443978 10.52460171 6 Serpina3c ENSMUSG00000066361.3 374.5845141 -1.157082603 0.353923541 -3.269301048 0.001078135 0.022900598 9.187009947 8.137391629 6 Serpina3n ENSMUSG00000021091.8 385.5407063 -1.285087478 0.301193868 -4.266645554 1.98E-05 0.000908917 9.298079487 8.128489293 6 Serpinf1 ENSMUSG00000000753.8 16429.56502 0.899321373 0.284108795 3.165411939 0.001548635 0.030017165 13.39261207 14.4204822 6 Sez6l2 ENSMUSG00000030683.4 56.73652229 -1.436769142 0.427361214 -3.361954936 0.000773928 0.017688772 7.294813048 6.356741384 6 Sh2b2 ENSMUSG00000005057.9 2037.819109 -1.737037879 0.39362255 -4.412953167 1.02E-05 0.000509788 11.58142622 9.594681897 6 Sh2d3c ENSMUSG00000059013.6 279.3147063 -1.662112906 0.313188051 -5.307076365 1.11E-07 1.00E-05 8.986291916 7.561533136 6 Sh3glb2 ENSMUSG00000026860.9 2301.926702 -0.96095281 0.319805179 -3.004806904 0.002657495 0.045298964 11.58675559 10.58129784 6 Sh3rf2 ENSMUSG00000057719.4 11.07215072 1.514250149 0.485658789 3.117930082 0.00182126 0.033888754 5.575872649 6.316210876 6 Sh3tc1 ENSMUSG00000036553.9 309.9245218 -1.566402095 0.367791483 -4.258940644 2.05E-05 0.000932996 9.047695229 7.659317068 6 Siglec1 ENSMUSG00000027322.4 1282.520711 -2.373588717 0.384482824 -6.173458395 6.68E-10 9.84E-08 11.07330107 8.471600735 6 Sik2 ENSMUSG00000037112.9 2173.443874 -1.049696903 0.314870306 -3.333743715 0.000856856 0.019218905 11.53010097 10.45178074 6 Six1 ENSMUSG00000051367.5 590.9246462 -0.890286925 0.269320453 -3.305678854 0.000947466 0.020743057 9.741647705 8.881372224 6 Slc13a4 ENSMUSG00000029843.4 601.5271622 -2.678721182 0.399649816 -6.702670877 2.05E-11 3.73E-09 10.03510492 7.40048729 6 Slc1a3 ENSMUSG00000005360.8 4286.269796 -2.369382934 0.300970224 -7.872482864 3.48E-15 1.19E-12 12.81806863 10.28396265 6 Slc1a4 ENSMUSG00000020142.6 1585.872879 0.955919473 0.225768383 4.234071494 2.29E-05 0.001019866 10.13880675 11.10144099 6 Slc22a15 ENSMUSG00000033147.8 215.602374 1.062952491 0.285582941 3.722044764 0.000197616 0.006091178 7.665258457 8.543277864 6 Slc25a10 ENSMUSG00000025792.3 5846.308393 -1.618835575 0.307438536 -5.265558427 1.40E-07 1.21E-05 13.11785075 11.35694783 6 Slc25a24 ENSMUSG00000040322.6 2043.554935 0.871903658 0.250428028 3.481653644 0.000498328 0.012649504 10.52235967 11.42671486 6 Slc25a25 ENSMUSG00000026819.9 672.1884174 -1.123272815 0.28998534 -3.873550351 0.000107261 0.003695104 9.977791449 8.8794318 6 Slc25a5 ENSMUSG00000016319.3 13067.35609 -1.129192751 0.330625718 -3.41532038 0.00063707 0.015350865 14.09664696 12.88740378 6 Slc27a1 ENSMUSG00000031808.6 2125.257007 -0.840706336 0.255272773 -3.293364691 0.00098996 0.021416043 11.46546109 10.59780034 6 Slc36a2 ENSMUSG00000020264.5 516.1039635 -2.521637915 0.347992833 -7.2462352 4.29E-13 1.02E-10 9.892229477 7.529117156 6 Slc38a1 ENSMUSG00000023169.8 132.8824509 1.89598646 0.337428842 5.618922337 1.92E-08 2.09E-06 6.799398546 8.187273013 6 Slc43a1 ENSMUSG00000027075.10 395.3041077 -2.054973757 0.368774362 -5.572442035 2.51E-08 2.66E-06 9.470621091 7.544097877 6 Slc46a3 ENSMUSG00000029650.4 232.2064957 -1.19259989 0.368822706 -3.233531638 0.001222698 0.025339871 8.624776764 7.603409405 6 Slc5a6 ENSMUSG00000006641.6 2268.538966 -1.486750677 0.306147444 -4.856322364 1.20E-06 7.97E-05 11.74288543 10.16492624 6 Slco3a1 ENSMUSG00000025790.8 388.1601216 1.443206883 0.351220436 4.1091199 3.97E-05 0.001621688 7.931116987 9.388561156 6 Slfn10-ps ENSMUSG00000072621.5 108.6211253 1.90841243 0.392721841 4.85945071 1.18E-06 7.88E-05 6.567349944 7.99470855 6 Slfn2 ENSMUSG00000072620.3 141.489733 2.83384811 0.342658548 8.270180705 1.34E-16 5.77E-14 6.42805393 8.364618836 6 Slfn8 ENSMUSG00000035208.9 300.3576668 2.751482016 0.378732971 7.264965635 3.73E-13 9.00E-11 6.819801536 9.28669972 6 Slfn9 ENSMUSG00000069793.5 663.3593922 1.789869084 0.357773236 5.002803184 5.65E-07 4.12E-05 8.236682393 10.17691761 6 Smoc1 ENSMUSG00000021136.7 244.1665729 -2.159978069 0.444396351 -4.860476613 1.17E-06 7.87E-05 8.777353073 6.821975213 6 Snap25 ENSMUSG00000027273.7 53.36516559 -1.988403028 0.428947492 -4.635539461 3.56E-06 0.000210751 7.315185385 6.130055719 Page 71 of 79 Diabetes
6 Sncg ENSMUSG00000023064.4 195.4343763 -1.92525834 0.4585476 -4.198600841 2.69E-05 0.001158947 8.396087796 6.772615526 6 Snhg12 ENSMUSG00000086290.1 438.1670676 0.77520208 0.25543197 3.034867095 0.002406417 0.042023884 8.602633851 9.314856002 6 Sorbs1 ENSMUSG00000025006.8 1880.665492 -1.542179683 0.335715616 -4.593708511 4.35E-06 0.000253202 11.45214339 9.846168106 6 Sorbs2 ENSMUSG00000031626.9 214.6672227 1.334701683 0.438335604 3.044931031 0.002327337 0.041008456 7.229417813 8.601723302 6 Sorbs3 ENSMUSG00000022091.5 1262.162523 0.957370091 0.283435645 3.377733564 0.000730859 0.016975381 9.790509599 10.78576626 6 Sort1 ENSMUSG00000068747.7 5811.038977 -1.888359235 0.33094453 -5.70596902 1.16E-08 1.32E-06 13.16211776 11.05911931 6 Sox5 ENSMUSG00000041540.9 128.2120222 -1.169809572 0.348601597 -3.355720635 0.000791585 0.018028345 7.989389911 7.11202451 6 Sp100 ENSMUSG00000026222.9 715.5954085 2.605971946 0.335456154 7.768442814 7.95E-15 2.51E-12 7.79159726 10.38681742 6 Sp110 ENSMUSG00000070034.7 154.8932921 2.0946338 0.368269403 5.687775801 1.29E-08 1.46E-06 6.760495586 8.383837471 6 Sp140 ENSMUSG00000070031.5 572.7076895 0.89536125 0.276922499 3.233255704 0.00122388 0.025339871 8.83273958 9.704910358 6 Sparcl1 ENSMUSG00000029309.3 7189.816825 -0.675954876 0.215844353 -3.131677378 0.001738108 0.032610398 13.13628558 12.43214646 6 Specc1 ENSMUSG00000042331.7 945.9406494 0.923002809 0.285105489 3.237408065 0.001206208 0.025155386 9.426988316 10.3906062 6 Spib ENSMUSG00000008193.6 38.75234901 1.63461114 0.444987657 3.673385352 0.000239358 0.007072061 6.088562409 7.033045327 6 Spns3 ENSMUSG00000020798.8 11.66890089 1.574808005 0.483629863 3.256225732 0.00112904 0.023858234 5.462276451 6.351242754 6 Spry4 ENSMUSG00000024427.6 1373.585455 -2.002245913 0.288211419 -6.94714291 3.73E-12 7.45E-10 11.17961197 9.110781297 6 Sqle ENSMUSG00000022351.8 3833.783648 -1.035453754 0.343837573 -3.011461907 0.00259993 0.04476165 12.29694732 11.21610431 6 Src ENSMUSG00000027646.8 1520.817019 0.752438816 0.253217885 2.971507383 0.002963417 0.049054819 10.19693494 10.97243913 6 Srpx2 ENSMUSG00000031253.9 2705.84463 1.08850916 0.29100694 3.740492104 0.00018366 0.005758436 10.69866893 11.91226884 6 St3gal6 ENSMUSG00000022747.10 74.89559408 -1.428745619 0.371624233 -3.844597563 0.00012075 0.004081702 7.531164602 6.60036477 6 Stat1 ENSMUSG00000026104.7 7179.843312 0.846263333 0.270953538 3.123278402 0.001788485 0.033440792 12.26922108 13.20850647 6 Stat2 ENSMUSG00000040033.8 2793.278109 1.788564928 0.250852926 7.12993448 1.00E-12 2.14E-10 10.26296007 12.13603437 6 Steap1 ENSMUSG00000015652.3 222.2753658 1.107462542 0.298600056 3.708849071 0.000208203 0.006381534 7.663024541 8.588535262 6 Stx1b ENSMUSG00000030806.5 141.5884228 -1.769639597 0.386854066 -4.574437111 4.78E-06 0.000270937 8.195102987 6.850561739 6 Sult1a1 ENSMUSG00000030711.8 889.2702321 -1.233395959 0.393188364 -3.136908596 0.001707393 0.032330067 10.34559422 8.961696074 6 Syde2 ENSMUSG00000036863.6 376.824848 -1.102988729 0.32589625 -3.384478124 0.000713137 0.016610825 9.20139363 8.201573265 6 Syt13 ENSMUSG00000027220.2 190.8365842 2.205141372 0.313867719 7.025702996 2.13E-12 4.37E-10 6.938526186 8.639103821 6 Tacc1 ENSMUSG00000065954.4 3148.378549 -0.934790277 0.259214917 -3.606236428 0.00031067 0.008693461 12.04719792 11.07812035 6 Tagln2 ENSMUSG00000026547.9 3032.862951 0.875214827 0.262882949 3.329294773 0.000870662 0.019424648 11.0509233 11.98693126 6 Taldo1 ENSMUSG00000025503.4 4170.183908 -1.300315567 0.353738041 -3.675927995 0.000236986 0.007047797 12.50899835 11.08262709 6 Tap1 ENSMUSG00000037321.9 1338.195394 1.574875492 0.270635722 5.81917081 5.91E-09 7.29E-07 9.430705256 11.05534062 6 Tap2 ENSMUSG00000024339.6 1012.581145 0.819695443 0.256712266 3.193051334 0.001407779 0.028255524 9.609077179 10.44221374 6 Tapbp ENSMUSG00000024308.7 7114.050288 0.802541023 0.219243956 3.660493266 0.00025173 0.007371199 12.33290696 13.16929104 6 Tbc1d24 ENSMUSG00000036473.8 1481.062008 -0.735652192 0.230790315 -3.187534935 0.001434911 0.028659774 10.92889646 10.18554839 6 Tcf7l2 ENSMUSG00000024985.11 903.3956013 -1.551809298 0.254079641 -6.107570408 1.01E-09 1.44E-07 10.50025464 8.978376035 6 Tes ENSMUSG00000029552.12 574.7766241 1.518411127 0.30620318 4.95883526 7.09E-07 5.01E-05 8.390665187 9.901927756 6 Tgfb1i1 ENSMUSG00000030782.8 1462.19785 0.722754854 0.242466117 2.980848886 0.002874506 0.048043946 10.16748657 10.90896638 6 Tgfb2 ENSMUSG00000039239.8 938.6842878 -1.122877262 0.326591334 -3.438172252 0.000585655 0.014333688 10.41495084 9.255089922 6 Tgtp1 ENSMUSG00000078922.3 816.2594173 2.427465298 0.424713286 5.715538877 1.09E-08 1.25E-06 7.614123958 10.60593337 6 Tgtp2 ENSMUSG00000078921.3 931.2527978 2.43146585 0.421845764 5.76387404 8.22E-09 9.99E-07 7.757908638 10.78553078 6 Thbs1 ENSMUSG00000040152.8 13358.29143 0.987755689 0.244725502 4.036178003 5.43E-05 0.002091284 13.09291985 14.13246102 6 Timp4 ENSMUSG00000030317.6 319.6838743 -2.960687017 0.300790695 -9.843013973 7.35E-23 8.03E-20 9.361105197 6.939906605 6 Tlr3 ENSMUSG00000031639.5 800.1421319 1.336484528 0.239100661 5.589631246 2.28E-08 2.42E-06 8.989843615 10.27991526 6 Tlr8 ENSMUSG00000040522.4 114.2339926 -1.788051168 0.360779068 -4.956083458 7.19E-07 5.04E-05 7.998781562 6.727185859 6 Tmcc3 ENSMUSG00000020023.10 1585.488025 -1.360704346 0.378659263 -3.593479627 0.000326291 0.009068682 11.15794341 9.65207036 6 Tmed5 ENSMUSG00000063406.5 3284.296377 -1.071643561 0.28965179 -3.699765019 0.000215799 0.00656526 12.13711906 11.02240472 6 Tmem106a ENSMUSG00000034947.7 484.8312789 0.85247908 0.250169774 3.407602226 0.000655364 0.015711479 8.680132282 9.470942895 6 Tmem120a ENSMUSG00000039886.2 6431.67816 -1.69820388 0.342585082 -4.9570281 7.16E-07 5.04E-05 13.2649383 11.33813414 6 Tmem120b ENSMUSG00000054434.8 969.1669965 -1.689829577 0.375033565 -4.505808909 6.61E-06 0.000353174 10.57056134 8.768904569 6 Tmem135 ENSMUSG00000039428.4 2187.347774 -1.008871892 0.33779167 -2.986668945 0.00282035 0.047288438 11.5146167 10.459329 6 Tmem173 ENSMUSG00000024349.8 485.8058997 1.228804343 0.364110557 3.374811081 0.000738664 0.017108614 8.28135754 9.626793373 6 Tmem179 ENSMUSG00000054013.5 294.5029583 -1.507859179 0.376094699 -4.009254008 6.09E-05 0.002312075 8.971098421 7.629057651 6 Tmem182 ENSMUSG00000079588.1 268.5137091 -2.01075377 0.432806388 -4.645850485 3.39E-06 0.000201219 8.889899789 7.049182633 6 Tmem45a ENSMUSG00000022754.5 832.6470571 0.807361859 0.241856559 3.33818468 0.000843277 0.018994578 9.377073601 10.16955695 6 Tmem53 ENSMUSG00000048772.8 360.3554418 -0.920261039 0.305839755 -3.008964739 0.002621395 0.044917076 9.10095874 8.274915983 6 Tmem88b ENSMUSG00000073680.2 40.37171752 -1.436417751 0.458407922 -3.133492423 0.001727394 0.032453269 6.998110885 6.158075477 6 Tnc ENSMUSG00000028364.8 3276.323982 1.241235244 0.400696867 3.097691418 0.001950344 0.035574794 10.52455942 12.25432344 6 Tnfrsf1a ENSMUSG00000030341.10 5574.713202 -0.752366055 0.251712328 -2.988991683 0.002798998 0.047171594 12.79309325 12.0098112 6 Tob1 ENSMUSG00000037573.5 3809.079747 -1.248650591 0.331015256 -3.772184414 0.000161825 0.00515262 12.37294668 11.04978589 6 Tor3a ENSMUSG00000060519.5 2055.437536 1.499311366 0.224757837 6.670785717 2.54E-11 4.54E-09 10.10610306 11.62593933 6 Tpm4 ENSMUSG00000031799.9 8014.574721 0.77385453 0.25303262 3.058319235 0.002225823 0.039672879 12.49280209 13.33677749 6 Trem2 ENSMUSG00000023992.8 185.823943 -1.846027083 0.395359083 -4.669241612 3.02E-06 0.000182255 8.508916885 6.978499166 6 Treml1 ENSMUSG00000023993.6 90.68837904 -1.620119745 0.402992779 -4.020220283 5.81E-05 0.002222474 7.717153624 6.603609492 6 Trim12c ENSMUSG00000057143.7 931.6478511 1.183019315 0.344235871 3.43665322 0.000588949 0.014392828 9.128693696 10.46890689 6 Trim16 ENSMUSG00000047821.8 340.0926632 0.802555468 0.269821011 2.974399449 0.002935627 0.04872308 8.292668484 9.004823807 6 Trim21 ENSMUSG00000030966.6 372.1301003 0.918159609 0.298678394 3.074074412 0.002111568 0.038049984 8.297481392 9.163984246 6 Trim29 ENSMUSG00000032013.5 81.77822694 -2.100708651 0.464182842 -4.525605988 6.02E-06 0.000324846 7.60647375 6.159825538 6 Trim30a ENSMUSG00000030921.9 2024.465644 1.939008107 0.348437268 5.564870029 2.62E-08 2.76E-06 9.486431531 11.73564536 6 Trim30d ENSMUSG00000057596.7 820.7080441 1.721107422 0.414804202 4.149204408 3.34E-05 0.001392089 8.29648515 10.4579441 6 Trim34a ENSMUSG00000056144.7 207.7751435 1.550521912 0.352565247 4.397829694 1.09E-05 0.000543314 7.288266044 8.633487344 6 Trim34b ENSMUSG00000090215.1 102.5862455 1.428843352 0.383206128 3.728654753 0.000192505 0.005967281 6.77663972 7.8343124 6 Trim5 ENSMUSG00000060441.7 346.1177223 1.164671264 0.38670382 3.011791465 0.002597109 0.04476165 7.913250873 9.178346414 6 Trim59 ENSMUSG00000034317.8 453.9339424 0.854083561 0.272000909 3.140002595 0.001689463 0.032064607 8.585738079 9.390269122 6 Trim67 ENSMUSG00000036913.8 49.62755185 -1.747893113 0.481400032 -3.630853753 0.000282485 0.008014174 7.154163028 5.975491975 6 Trpv1 ENSMUSG00000005952.9 41.1469014 -1.455092146 0.449845802 -3.234646496 0.001217934 0.025312656 7.024429575 6.180499518 6 Tshr ENSMUSG00000020963.8 369.0694333 -2.126245705 0.42702241 -4.979236811 6.38E-07 4.56E-05 9.264111898 7.273827979 6 Tspan12 ENSMUSG00000029669.7 1735.71253 -1.789521496 0.340743205 -5.251818577 1.51E-07 1.29E-05 11.39464393 9.523360982 6 Tspan7 ENSMUSG00000058254.6 168.8755213 1.710181147 0.367426801 4.654481227 3.25E-06 0.000193674 7.017007128 8.419087048 6 Tst ENSMUSG00000044986.7 791.9217704 -1.73844339 0.406202509 -4.279745579 1.87E-05 0.000869173 10.24545048 8.409995744 6 Tubb6 ENSMUSG00000001473.6 1634.867077 1.016812116 0.29531699 3.443120952 0.000575042 0.014158468 10.06242553 11.18135405 6 Tuft1 ENSMUSG00000005968.7 80.48345536 1.265464587 0.374433945 3.379673784 0.000725719 0.016879918 6.700192413 7.571423112 6 Tusc5 ENSMUSG00000046275.2 640.7190588 -1.580132929 0.450530051 -3.507275321 0.00045272 0.011791072 9.724745453 8.157249319 6 Txlng ENSMUSG00000038344.8 1267.177088 -1.192910372 0.343937587 -3.468391994 0.000523583 0.013095691 10.80835039 9.587137718 6 Uba7 ENSMUSG00000032596.7 570.7923094 1.162816432 0.309026119 3.762841909 0.000167993 0.005338674 8.620784664 9.792086342 6 Ube2l6 ENSMUSG00000027078.7 814.3190703 1.554063532 0.275206958 5.646890406 1.63E-08 1.81E-06 8.81975469 10.36982579 6 Ucp2 ENSMUSG00000033685.5 3030.71849 -0.798046745 0.261181391 -3.055526827 0.002246655 0.039870833 11.95264859 11.1084621 6 Uqcr11 ENSMUSG00000020163.6 1755.047913 -1.032958172 0.288298387 -3.582948149 0.000339738 0.009300542 11.24564177 10.19234985 Diabetes Page 72 of 79
6 Uqcrfs1 ENSMUSG00000038462.3 4230.192787 -1.236823928 0.385085128 -3.21181951 0.001318972 0.026834373 12.47555068 11.08163013 6 Uqcrh ENSMUSG00000063882.6 2528.576725 -0.711117798 0.225082851 -3.159360193 0.001581159 0.030467511 11.66518814 10.93633341 6 Usmg5 ENSMUSG00000071528.3 1256.066413 -0.755262499 0.253883468 -2.974839229 0.002931421 0.04872308 10.70183008 9.946289556 6 Usp18 ENSMUSG00000030107.9 766.8672107 2.434248567 0.252296141 9.648378106 4.99E-22 4.55E-19 8.162032223 10.44579251 6 Usp46 ENSMUSG00000054814.8 1256.944664 -0.741640421 0.23788178 -3.117684845 0.001822776 0.033888754 10.70246324 9.960813039 6 Vegfa ENSMUSG00000023951.9 4127.02826 -1.027558837 0.286263202 -3.58955964 0.000331237 0.009128782 12.4484977 11.37546935 6 Vegfc ENSMUSG00000031520.4 905.5646251 1.070441118 0.323442994 3.30952019 0.00093456 0.020505988 9.212431779 10.39327586 6 Vkorc1l1 ENSMUSG00000066735.5 1755.245977 -0.924533741 0.285553418 -3.237691035 0.001205012 0.025155386 11.20955613 10.27100615 6 Vnn3 ENSMUSG00000020010.7 48.0937004 -1.469971752 0.444197845 -3.309272588 0.000935387 0.020505988 7.142601771 6.251311385 6 Vps13c ENSMUSG00000035284.8 3663.396441 -0.940571238 0.295730807 -3.180497993 0.001470222 0.029116779 12.24335059 11.26609558 6 Vstm2a ENSMUSG00000048834.8 248.427636 -1.277130248 0.381504002 -3.347619529 0.000815088 0.018435611 8.751874169 7.574786932 6 Wdr93 ENSMUSG00000039099.7 77.84780232 -1.54472441 0.422741931 -3.654060066 0.000258126 0.007504871 7.566614092 6.501330894 6 Wls ENSMUSG00000028173.6 6705.35945 0.709413924 0.229233705 3.094719094 0.001969994 0.035893286 12.30262467 13.05184059 6 Wnk4 ENSMUSG00000035112.10 569.0018126 -1.019667248 0.336750263 -3.027962737 0.002462084 0.042768285 9.703603818 8.707259686 6 Xaf1 ENSMUSG00000040483.9 783.728033 2.455486981 0.318793858 7.702428752 1.34E-14 4.05E-12 8.038136058 10.49185102 6 Xbp1 ENSMUSG00000020484.11 4389.723568 -1.173377488 0.322196094 -3.641811652 0.000270726 0.007802051 12.56414887 11.31339434 6 Xpnpep2 ENSMUSG00000037005.9 631.5147362 1.00166005 0.325779678 3.074654797 0.002107463 0.038049984 8.814059406 9.887601987 6 Xrcc3 ENSMUSG00000021287.6 501.8583626 -0.927433774 0.287538156 -3.225428543 0.001257842 0.025912184 9.531753264 8.657681579 6 Yeats4 ENSMUSG00000020171.6 2239.322245 1.29787543 0.234037626 5.545584489 2.93E-08 3.00E-06 10.35952381 11.69439194 6 Zbp1 ENSMUSG00000027514.8 374.1976989 3.47591702 0.284113232 12.23426658 2.04E-34 8.36E-31 6.825963888 9.598681415 6 Zbtb16 ENSMUSG00000066687.4 692.8237562 -0.956873588 0.300805265 -3.181040023 0.001467474 0.029097498 9.955280991 9.022778914 6 Zc3hav1 ENSMUSG00000029826.8 3220.905173 0.928681531 0.219447797 4.231901821 2.32E-05 0.00102413 11.13156988 12.08705714 8 1100001G20Rik ENSMUSG00000051748.2 149.8338381 -1.96669089 0.435021799 -4.520901932 6.16E-06 0.000685829 8.193420744 6.567041214 8 1300015D01Rik ENSMUSG00000087382.1 113.2498119 -2.214239879 0.500796464 -4.421436725 9.80E-06 0.001001563 7.679120251 5.875509612 8 1500003O03Rik ENSMUSG00000014077.7 9740.401727 -1.076481777 0.343213616 -3.136477482 0.001709906 0.048601113 13.66283026 12.51414735 8 1700018A04Rik ENSMUSG00000038408.7 35.61233011 -1.55395183 0.474982072 -3.271601016 0.001069404 0.034762724 6.798481885 5.857500886 8 1700023L04Rik ENSMUSG00000045709.10 51.83792752 -1.918196432 0.503516437 -3.809600427 0.000139192 0.0078464 7.024504538 5.674077515 8 2010002M12Rik ENSMUSG00000067297.4 277.829501 2.318496991 0.443516025 5.227538269 1.72E-07 4.45E-05 6.703608353 9.074821252 8 2010003K11Rik ENSMUSG00000042041.6 143.2315929 -2.492251799 0.49861644 -4.998334586 5.78E-07 0.000105944 7.964489413 5.835275956 8 2400009B08Rik ENSMUSG00000089665.1 168.5102962 -1.905188761 0.462160095 -4.122356688 3.75E-05 0.003038891 8.244118749 6.601604843 8 3110039M20Rik ENSMUSG00000089922.1 25.50566749 2.289558766 0.491637596 4.657005044 3.21E-06 0.000405212 5.428471412 6.660577047 8 3930402G23Rik ENSMUSG00000038917.3 84.11485943 -2.254348398 0.497444976 -4.53185479 5.85E-06 0.000674985 7.465545858 5.780393456 8 4632428N05Rik ENSMUSG00000020101.7 1602.004372 -2.116350523 0.464633416 -4.554882302 5.24E-06 0.000613509 11.10643595 8.601419798 8 5730469M10Rik ENSMUSG00000021792.9 2686.845841 -1.69916861 0.444167273 -3.825515097 0.000130499 0.007450925 11.81033174 9.893062242 8 5730508B09Rik ENSMUSG00000050549.7 362.8432637 -1.692464871 0.485455073 -3.486347068 0.000489665 0.019650734 8.957247408 7.250847141 8 6430571L13Rik ENSMUSG00000037977.4 110.8196271 -1.956177281 0.475711038 -4.112112446 3.92E-05 0.003117757 7.779627741 6.236676974 8 9130204L05Rik ENSMUSG00000091175.1 8.656607153 1.655260515 0.495485112 3.340686685 0.000835715 0.028688334 4.995335464 6.033658965 8 9130208D14Rik ENSMUSG00000086513.1 553.4580868 1.786852117 0.453061717 3.94394858 8.02E-05 0.005195933 7.606303696 9.964697685 8 9630013D21Rik ENSMUSG00000059027.8 122.5470421 -1.64493606 0.482037381 -3.412465766 0.00064378 0.024059676 7.79409358 6.458513779 8 9930013L23Rik ENSMUSG00000052353.7 518.4646262 1.578344175 0.341406063 4.623070141 3.78E-06 0.000465176 8.137523673 9.760736426 8 A530016L24Rik ENSMUSG00000043122.6 2662.621706 -2.121040825 0.45156633 -4.697074797 2.64E-06 0.000350257 11.86227371 9.359686925 8 A530020G20Rik ENSMUSG00000086471.1 176.1487169 -2.172455784 0.410788793 -5.288498177 1.23E-07 3.65E-05 8.432788419 6.625040772 8 A730085A09Rik ENSMUSG00000085843.1 18.14070505 1.819694932 0.502133078 3.623929612 0.000290161 0.013325122 5.428471412 6.401284529 8 Abca8b ENSMUSG00000020620.8 590.6374983 1.333583723 0.374397022 3.561950665 0.00036811 0.015747428 8.387707397 9.888257023 8 Abcb1b ENSMUSG00000028970.5 291.7762901 1.452553763 0.339015322 4.2846257 1.83E-05 0.001704563 7.612771835 8.972763718 8 Abcb8 ENSMUSG00000028973.11 1596.482751 -1.176548166 0.373394896 -3.150948712 0.001627411 0.046649671 11.09301462 9.873710519 8 Abcc4 ENSMUSG00000032849.7 725.5515164 0.967652563 0.260747463 3.711071824 0.000206384 0.010225665 9.065341412 10.0216342 8 Abcd2 ENSMUSG00000055782.7 1691.679207 -2.27183329 0.440835868 -5.153467431 2.56E-07 5.96E-05 11.26916329 8.714204772 8 Abcg1 ENSMUSG00000024030.6 406.3919686 -1.603717583 0.465450451 -3.4455173 0.000569967 0.022033949 9.195753408 7.574329683 8 Abhd15 ENSMUSG00000000686.11 551.5782127 -1.792415622 0.443703578 -4.039669077 5.35E-05 0.003974414 9.698286785 7.834439295 8 Acacb ENSMUSG00000042010.10 756.9564905 -1.091838547 0.314201663 -3.474961075 0.000510927 0.020167875 10.10521242 9.004099638 8 Acad10 ENSMUSG00000029456.6 915.7840689 -1.21024473 0.321194562 -3.767949008 0.000164594 0.00883515 10.38911881 9.165309963 8 Acad11 ENSMUSG00000090150.1 1517.227548 -1.437975044 0.415704364 -3.459129055 0.000541925 0.021143863 11.01872867 9.507176871 8 Acads ENSMUSG00000029545.7 3782.228704 -1.50917765 0.398980409 -3.782585854 0.000155208 0.008521247 12.36507531 10.71438829 8 Acat2 ENSMUSG00000023832.7 4072.314984 -1.341058082 0.360569242 -3.719280313 0.000199791 0.010103363 12.48678028 11.03479961 8 Acat3 ENSMUSG00000062480.5 1428.352769 -1.461099169 0.364816448 -4.005025477 6.20E-05 0.004373188 11.03639811 9.499611697 8 Aco1 ENSMUSG00000028405.8 6525.864241 -1.338220918 0.412205887 -3.246486672 0.001168389 0.037156981 13.06862573 11.60448285 8 Acsm5 ENSMUSG00000030972.5 55.44176559 -1.541573351 0.476166671 -3.237465885 0.001205964 0.037922605 7.176875902 6.019050884 8 Acss2 ENSMUSG00000027605.11 1487.656757 -1.226174627 0.319814739 -3.834015379 0.000126068 0.007276988 11.08550083 9.773265957 8 Acss3 ENSMUSG00000035948.6 56.45273983 -1.362588756 0.404826362 -3.365859745 0.000763055 0.027076403 7.159091846 6.267021934 8 Acta2 ENSMUSG00000035783.8 6965.505794 1.291630262 0.299524911 4.312263243 1.62E-05 0.001538775 11.88513629 13.30341661 8 Adam12 ENSMUSG00000054555.5 2923.140155 -1.192102289 0.345445568 -3.450912097 0.000558696 0.021747835 11.98187086 10.71990458 8 Adamts9 ENSMUSG00000030022.8 1840.291217 -1.019406453 0.266362842 -3.82713461 0.000129644 0.00743246 11.32609177 10.26181818 8 Adamtsl1 ENSMUSG00000066113.8 102.6679328 1.823489086 0.463384133 3.93515651 8.31E-05 0.005308208 6.251194613 7.833254445 8 Adar ENSMUSG00000027951.10 2607.007461 1.155466374 0.366074206 3.156371998 0.00159745 0.046067247 10.47425173 11.88287894 8 Adck3 ENSMUSG00000026489.7 661.0008384 -1.687026554 0.425869759 -3.961367341 7.45E-05 0.004945136 9.949719917 8.202391341 8 Add3 ENSMUSG00000025026.8 3258.332973 -1.155419145 0.260339827 -4.438119052 9.07E-06 0.000944176 12.17419996 10.96279707 8 Adhfe1 ENSMUSG00000025911.8 2144.245539 -2.128971621 0.443228905 -4.803323065 1.56E-06 0.000228721 11.57810192 9.141945446 8 Adig ENSMUSG00000044405.4 1083.443251 -2.187037258 0.468813671 -4.665045826 3.09E-06 0.000393983 10.53322302 8.048049063 8 Adipoq ENSMUSG00000022878.5 34313.51796 -2.036532856 0.442820901 -4.598998942 4.25E-06 0.000514776 15.540112 13.07390608 8 Adipor2 ENSMUSG00000030168.7 9974.497138 -1.564596865 0.432010494 -3.621664025 0.000292714 0.013370451 13.67879237 11.91976294 8 Agpat2 ENSMUSG00000026922.7 4865.057159 -1.606439725 0.461573763 -3.480353205 0.000500753 0.019953178 12.53134698 10.71901584 8 Agpat9 ENSMUSG00000029314.8 3443.341197 -1.98111027 0.476107897 -4.161053161 3.17E-05 0.002703868 12.04807176 9.624723662 8 Agt ENSMUSG00000031980.9 6298.688036 -1.24294131 0.392406474 -3.167484206 0.001537641 0.044761542 13.02005307 11.69454728 8 Agtr2 ENSMUSG00000068122.3 1239.519894 1.929536159 0.413364106 4.667885123 3.04E-06 0.000391545 8.68888993 10.99059678 8 Ahcyl2 ENSMUSG00000029772.9 2760.494027 -0.916634706 0.289952842 -3.161323401 0.00157054 0.045561885 11.85354028 10.88258671 8 Aldh1a7 ENSMUSG00000024747.3 1549.50131 -1.83111648 0.4636891 -3.949017736 7.85E-05 0.005148122 11.04269768 8.861197696 8 Aldh1l2 ENSMUSG00000020256.8 2992.608083 1.125653708 0.312219355 3.605329678 0.000311757 0.014012434 10.8029839 12.05242203 8 Aldh3b2 ENSMUSG00000075296.4 462.8151292 -1.888231666 0.454613762 -4.153485499 3.27E-05 0.002766539 9.422354448 7.542350175 8 Aldh4a1 ENSMUSG00000028737.9 2048.98827 -1.380904446 0.359485678 -3.841333689 0.000122368 0.007120902 11.52113106 10.06104847 8 Aldh6a1 ENSMUSG00000021238.9 6694.743735 -1.739700932 0.440548497 -3.948943061 7.85E-05 0.005148122 13.13106987 11.12052521 8 Angptl1 ENSMUSG00000033544.6 115.924493 -1.588264925 0.46851809 -3.389975667 0.000698988 0.025445891 7.779503105 6.513100791 8 Angptl4 ENSMUSG00000002289.9 2795.819425 -1.393928067 0.390874168 -3.566181087 0.000362221 0.015534954 11.93459397 10.40671756 8 Angptl6 ENSMUSG00000038742.5 207.4191567 1.138148801 0.315321545 3.609486315 0.000306804 0.013853311 7.481460627 8.467887402 8 Ankrd1 ENSMUSG00000024803.8 31.26557865 1.879752331 0.467819096 4.018118002 5.87E-05 0.00420764 5.702325465 6.768338419 8 Ankrd5 ENSMUSG00000074771.3 169.7781165 -1.146785095 0.360592058 -3.180283842 0.001471309 0.043293763 8.218288053 7.256112631 Page 73 of 79 Diabetes
8 Anxa3 ENSMUSG00000029484.8 655.7656266 1.402602889 0.311250612 4.506345809 6.60E-06 0.00072372 8.602853252 10.01078679 8 Aoc3 ENSMUSG00000019326.8 9686.170961 -1.833875968 0.460280637 -3.984256173 6.77E-05 0.004695249 13.57158138 11.42066921 8 Apod ENSMUSG00000022548.8 8151.676495 1.446112124 0.308424112 4.688712934 2.75E-06 0.000362025 11.99433646 13.54757184 8 Apol10b ENSMUSG00000050014.6 100.0770517 1.309663224 0.40131256 3.263449379 0.001100648 0.035471185 6.653611987 7.715289217 8 Apol9a ENSMUSG00000068246.4 477.919412 2.096682835 0.439103307 4.774919255 1.80E-06 0.00025899 7.314180836 9.802706189 8 Apol9b ENSMUSG00000057346.4 469.4139389 2.18484479 0.43629898 5.007677965 5.51E-07 0.000103172 7.244699014 9.793154963 8 Aqp7 ENSMUSG00000028427.7 611.6626283 -1.880184666 0.474168861 -3.965221716 7.33E-05 0.004904521 9.694737734 7.698817398 8 Arhgap19 ENSMUSG00000025154.7 462.3984137 -0.965936095 0.306252254 -3.15405383 0.001610194 0.046234782 9.413516463 8.48220254 8 Arhgef37 ENSMUSG00000045094.6 25.79488816 -1.810608934 0.50026143 -3.61932547 0.000295372 0.013419122 6.476228909 5.139323094 8 Arl4a ENSMUSG00000047446.12 1425.506547 -1.568330252 0.472947492 -3.316076896 0.000912907 0.030712672 10.71379739 9.06112708 8 Armcx4 ENSMUSG00000049804.8 2355.029914 -0.919361873 0.287728427 -3.195241716 0.001397138 0.041532199 11.62965188 10.66253176 8 Art3 ENSMUSG00000034842.9 138.1085611 -1.620152629 0.504217214 -3.21320372 0.001312631 0.039944941 7.721791961 6.31825149 8 Atp1a2 ENSMUSG00000007097.8 4178.628242 -2.10886238 0.442448888 -4.766341239 1.88E-06 0.000267968 12.52917424 10.04164855 8 Atp1a4 ENSMUSG00000007107.5 137.1247292 -2.27274035 0.451260217 -5.036429679 4.74E-07 9.19E-05 8.10695587 6.286582875 8 Atp2a3 ENSMUSG00000020788.9 69.08113163 2.264655176 0.403010604 5.619343899 1.92E-08 7.69E-06 6.021660533 7.483131143 8 B430010I23Rik ENSMUSG00000084960.1 29.47744321 -1.712624976 0.505917545 -3.38518597 0.0007113 0.02578273 6.555357438 5.44180292 8 B430219N15Rik ENSMUSG00000085211.1 25.79533054 -1.626052874 0.5059471 -3.213879227 0.001309547 0.039944941 6.532441872 5.543477645 8 BC006779 ENSMUSG00000027580.10 2099.230499 1.198469143 0.352925839 3.39581014 0.000684258 0.025126731 10.17789345 11.5856242 8 BC023105 ENSMUSG00000063388.3 35.25581588 1.892430399 0.492405734 3.843233879 0.000121424 0.007106235 5.632768441 6.854394105 8 BC046404 ENSMUSG00000046417.8 365.9299151 1.077323644 0.301299025 3.575596182 0.000349431 0.015101677 8.132633771 9.157410979 8 Bcar3 ENSMUSG00000028121.4 963.361393 -1.634226491 0.459699974 -3.554984954 0.000378001 0.016129626 10.3255349 8.552531737 8 Bcat1 ENSMUSG00000030268.10 715.2306923 1.350043798 0.365320953 3.695500593 0.000219454 0.01073635 8.624223399 10.15100951 8 Bcat2 ENSMUSG00000030826.9 4305.806153 -1.642303767 0.453604473 -3.620563432 0.000293962 0.013391169 12.40245785 10.56533653 8 Bche ENSMUSG00000027792.5 52.21716521 2.937198195 0.45867857 6.403608953 1.52E-10 1.28E-07 5.528534701 7.29284626 8 Bckdha ENSMUSG00000060376.6 2627.804874 -1.231197246 0.380482023 -3.23588809 0.001212649 0.038061828 11.7973323 10.49894678 8 Bckdhb ENSMUSG00000032263.7 2160.916819 -1.438907344 0.426017299 -3.377579617 0.000731268 0.026392974 11.49782929 9.936218516 8 Bcl6 ENSMUSG00000022508.5 426.2479382 -1.250366285 0.32690566 -3.824853584 0.00013085 0.007450925 9.385324525 8.188433543 8 Bnip3 ENSMUSG00000078566.2 4826.941233 -1.729883618 0.473596289 -3.652654504 0.000259543 0.012278791 12.43206268 10.49711707 8 Brp44 ENSMUSG00000026568.5 2260.42559 -1.34320131 0.398098363 -3.374043789 0.000740726 0.026624476 11.59639003 10.15731559 8 Bscl2 ENSMUSG00000071657.6 682.6684453 -1.697528092 0.475372812 -3.570940636 0.000355702 0.015294258 9.766543099 8.010752098 8 Bst2 ENSMUSG00000046718.7 3534.802154 2.01617675 0.385650925 5.227983696 1.71E-07 4.45E-05 10.04188014 12.54652937 8 C130026I21Rik ENSMUSG00000052477.9 300.9816209 1.40592058 0.372988291 3.7693424 0.000163678 0.008814046 7.602732167 9.022925506 8 C530028O21Rik ENSMUSG00000030329.5 73.59564715 -1.373615676 0.39419146 -3.484640877 0.000492798 0.019729477 7.41031346 6.429139485 8 C77080 ENSMUSG00000050390.6 819.8333218 1.030721712 0.317631503 3.245023564 0.001174409 0.037208016 9.144659718 10.19356392 8 Cables1 ENSMUSG00000040957.8 270.7057744 -1.553880808 0.470322977 -3.303859019 0.000953638 0.031854009 8.682981414 7.196379823 8 Camk1g ENSMUSG00000016179.5 28.89988839 -1.866714401 0.49343545 -3.783097464 0.000154889 0.008521247 6.684899874 5.600127913 8 Camp ENSMUSG00000038357.7 178.6536897 -1.820238184 0.485661157 -3.747959162 0.000178279 0.009412352 8.208908735 6.556695728 8 Camsap3 ENSMUSG00000044433.8 263.5626698 -1.146598424 0.355187589 -3.228148895 0.001245941 0.038746008 8.765837925 7.671794314 8 Car3 ENSMUSG00000027559.4 2574.719043 -2.002489885 0.472843249 -4.234997306 2.29E-05 0.002049088 11.78278556 9.170774549 8 Car5b ENSMUSG00000031373.4 3709.895321 -1.420460008 0.423755881 -3.35207149 0.000802093 0.027932393 12.25242232 10.70840359 8 Car6 ENSMUSG00000028972.5 35.1180046 1.851942857 0.463697152 3.993862911 6.50E-05 0.00452755 5.763628704 6.849792863 8 Cav2 ENSMUSG00000000058.6 9753.412208 -1.402471654 0.415972584 -3.371548288 0.000747469 0.026805523 13.63734342 12.11743099 8 Ccdc125 ENSMUSG00000048924.6 86.36373682 -1.73364227 0.481925136 -3.597326931 0.000321504 0.014335859 7.527040782 6.166412422 8 Ccdc144b ENSMUSG00000047696.9 112.9712669 -2.186517136 0.460055474 -4.752724966 2.01E-06 0.000284259 7.909904836 6.166412422 8 Ccdc85a ENSMUSG00000032878.10 48.98716305 2.475791792 0.459166096 5.391930752 6.97E-08 2.35E-05 5.665984272 7.197703936 8 Ccl5 ENSMUSG00000035042.2 43.28299084 1.50306633 0.462428678 3.250374384 0.001152532 0.036805384 5.98058652 6.95806712 8 Ccl7 ENSMUSG00000035373.2 695.6607772 1.628061469 0.367661873 4.428148772 9.50E-06 0.000982815 8.382802941 10.1728454 8 Cct2 ENSMUSG00000034024.7 12390.17323 0.801343072 0.243116288 3.296130745 0.000980264 0.032524305 13.11739202 13.96523869 8 Cd36 ENSMUSG00000002944.8 25346.01883 -1.946473138 0.459780285 -4.233485434 2.30E-05 0.002052003 15.02981177 12.59951375 8 Cd74 ENSMUSG00000024610.8 302.3236226 2.46703425 0.363094798 6.794463225 1.09E-11 1.67E-08 6.953710155 9.209669985 8 Cdsn ENSMUSG00000039518.7 5552.495389 2.22145398 0.342135671 6.492903754 8.42E-11 8.35E-08 10.63155512 13.22182684 8 Cebpa ENSMUSG00000034957.9 5956.942937 -1.84817136 0.457345112 -4.041086946 5.32E-05 0.003974414 12.93704482 10.70853165 8 Ces1f ENSMUSG00000031725.8 2831.956606 -2.15607554 0.403577067 -5.342413431 9.17E-08 2.97E-05 12.0976954 9.66034046 8 Cfd ENSMUSG00000061780.5 40989.886 -1.85998922 0.449155124 -4.14108427 3.46E-05 0.002870065 15.72228673 13.50870006 8 Cfh ENSMUSG00000026365.9 1751.809796 2.388526728 0.441943921 5.404592341 6.50E-08 2.23E-05 8.424826551 11.59630244 8 Cfhr2 ENSMUSG00000033898.10 159.186915 2.510249927 0.433370279 5.792390594 6.94E-09 3.77E-06 6.272625338 8.403069282 8 Chac1 ENSMUSG00000027313.3 611.0673677 1.008290003 0.277665703 3.63130913 0.000281987 0.013093371 8.814789041 9.799766429 8 Chn1 ENSMUSG00000056486.10 46.62590507 -1.525767285 0.482302069 -3.163509724 0.001558791 0.045299017 6.969089473 5.96766807 8 Chn2 ENSMUSG00000004633.9 61.26701393 -2.446968923 0.414899601 -5.897737475 3.69E-09 2.22E-06 7.388847621 5.881312164 8 Chst15 ENSMUSG00000030930.7 173.5215182 -1.265861805 0.388224718 -3.260641963 0.001111603 0.035626055 8.269969265 7.174127038 8 Cib2 ENSMUSG00000037493.6 961.5823821 -2.067627475 0.444828961 -4.648140425 3.35E-06 0.00041818 10.44677114 8.223034436 8 Cldn15 ENSMUSG00000001739.7 4083.400587 -1.608957057 0.302650887 -5.316214585 1.06E-07 3.25E-05 12.64027577 10.85738371 8 Clec14a ENSMUSG00000045930.2 986.2773102 -1.622371657 0.343475128 -4.723403596 2.32E-06 0.000315256 10.65414669 8.863949846 8 Clmn ENSMUSG00000021097.7 113.5237668 -1.92232226 0.393926743 -4.879897835 1.06E-06 0.000163041 7.931492153 6.475049965 8 Cmpk2 ENSMUSG00000020638.7 394.476354 2.621049077 0.448728565 5.841056893 5.19E-09 2.91E-06 6.74667506 9.522357322 8 Cndp1 ENSMUSG00000056162.7 78.24708497 -2.120359226 0.499486615 -4.245077175 2.19E-05 0.001969585 7.375766069 5.79763456 8 Cnn2 ENSMUSG00000004665.4 7343.839732 0.883279121 0.26073364 3.387668432 0.000704894 0.025605586 12.30796219 13.23985367 8 Cnnm2 ENSMUSG00000064105.5 1239.560811 -1.097168314 0.330494617 -3.319776654 0.000900895 0.030491132 10.76314707 9.637670494 8 Cnr1 ENSMUSG00000044288.6 60.17035691 -1.640528421 0.488730426 -3.356714325 0.000788746 0.02759076 7.161209202 6.011321002 8 Col15a1 ENSMUSG00000028339.11 5437.835245 -1.95734725 0.421507348 -4.643684761 3.42E-06 0.000424163 12.92510749 10.70053964 8 Cox6a2 ENSMUSG00000030785.7 45.56736089 1.561811735 0.435665196 3.584889842 0.000337221 0.014686955 6.036237106 7.008254087 8 Cox8b ENSMUSG00000025488.8 108.1491578 -1.54461691 0.491333634 -3.143723131 0.001668132 0.047686234 7.615090338 6.384086742 8 Cpt2 ENSMUSG00000028607.9 2888.059279 -1.337362335 0.413590393 -3.233543034 0.001222649 0.03830437 11.89848432 10.47159327 8 Csf2rb ENSMUSG00000071713.3 84.19147776 -1.466365993 0.380662858 -3.852138351 0.000117091 0.006924793 7.554924931 6.50274358 8 Csmd1 ENSMUSG00000060924.7 34.93981456 3.110216634 0.481720737 6.456472378 1.07E-10 9.51E-08 5.30223805 6.951909404 8 Ctgf ENSMUSG00000019997.4 37.0627201 1.993435175 0.459127079 4.341793951 1.41E-05 0.001401186 5.745466797 6.90788827 8 Cxcl10 ENSMUSG00000034855.7 160.4552218 2.81517943 0.40913323 6.88083789 5.95E-12 1.25E-08 6.220174231 8.425173013 8 Cxcl13 ENSMUSG00000023078.4 58.83184878 2.390155726 0.463705976 5.154463933 2.54E-07 5.96E-05 5.747299457 7.343530917 8 Cyb5r1 ENSMUSG00000026456.11 3120.04472 1.228394008 0.272708476 4.504421807 6.66E-06 0.00072372 10.83100446 12.14182932 8 Cycs ENSMUSG00000063694.5 4011.377038 -1.391901367 0.433495515 -3.21087836 0.001323299 0.039971704 12.32485802 10.81417119 8 Cyp51 ENSMUSG00000001467.4 2976.392263 -1.351657108 0.328705735 -4.112058191 3.92E-05 0.003117757 12.09077584 10.61387499 8 Cyr61 ENSMUSG00000028195.3 818.5487758 1.457557373 0.29583253 4.926967878 8.35E-07 0.000140765 8.859737485 10.32258125 8 D14Ertd668e ENSMUSG00000068245.7 498.0036971 2.085690658 0.406798137 5.127089996 2.94E-07 6.53E-05 7.568725266 9.772238666 8 D4Bwg0951e ENSMUSG00000048706.3 1227.339116 1.025320593 0.323165465 3.17274184 0.001510067 0.04426467 9.637064761 10.77896202 8 Dach2 ENSMUSG00000025592.10 47.46135994 2.254324564 0.451718983 4.990546439 6.02E-07 0.000108931 5.756921539 7.146828984 8 Dapk1 ENSMUSG00000021559.7 1595.666761 -1.91437388 0.363851903 -5.261409553 1.43E-07 4.05E-05 11.29453057 9.260042626 Diabetes Page 74 of 79
8 Dbi ENSMUSG00000026385.9 5628.357756 -1.701571053 0.421557308 -4.036393201 5.43E-05 0.003985605 12.92562124 11.01111956 8 Dbt ENSMUSG00000000340.6 1550.369908 -1.599957096 0.464912732 -3.441413813 0.000578683 0.022319676 10.89687966 9.182730653 8 Ddx51 ENSMUSG00000029504.5 1441.043726 -0.838614782 0.261079707 -3.212102507 0.001317674 0.039944941 10.92187966 10.05411595 8 Ddx58 ENSMUSG00000040296.8 3003.602879 1.350502612 0.342857976 3.938956375 8.18E-05 0.00526473 10.56808773 12.13684173 8 Ddx60 ENSMUSG00000037921.8 547.3340595 2.443467977 0.408733987 5.978137504 2.26E-09 1.52E-06 7.368892522 9.965331494 8 Dennd2d ENSMUSG00000027901.5 233.2340779 -1.556155622 0.483864088 -3.216100679 0.001299452 0.039822308 8.429186368 6.996087202 8 Dgat1 ENSMUSG00000022555.5 4456.399543 -1.611110825 0.438513324 -3.674029353 0.000238755 0.011497772 12.53597743 10.69502321 8 Dhcr24 ENSMUSG00000034926.3 1654.838413 -1.283839691 0.388848972 -3.301640952 0.00096121 0.03201818 11.15535261 9.807915045 8 Dhx58 ENSMUSG00000017830.8 663.2309046 1.669247934 0.411263935 4.058824007 4.93E-05 0.00377862 8.154560898 10.12317875 8 Disp2 ENSMUSG00000040035.7 480.779419 -1.999094461 0.409700162 -4.87940852 1.06E-06 0.000163041 9.618734991 7.651540468 8 Dmd ENSMUSG00000045103.10 148.9636897 2.554905693 0.395309703 6.463048274 1.03E-10 9.51E-08 6.332506794 8.323541926 8 Dpt ENSMUSG00000026574.4 6063.815638 1.277827693 0.253372954 5.043267935 4.58E-07 8.97E-05 11.74599332 13.10320148 8 Dtna ENSMUSG00000024302.8 303.2717805 1.618738 0.420715944 3.847579405 0.000119291 0.007005726 7.329645854 9.108399532 8 Dtx3l ENSMUSG00000049502.10 1260.448148 1.281533517 0.327499805 3.913081767 9.11E-05 0.005701144 9.524419454 10.845155 8 Dusp6 ENSMUSG00000019960.6 385.275191 -1.032754983 0.292199659 -3.534415431 0.000408678 0.017135002 9.202203223 8.232637441 8 Ebf2 ENSMUSG00000022053.6 260.8541935 -1.477500409 0.300337361 -4.919469239 8.68E-07 0.000144818 8.83493047 7.527396571 8 Echdc1 ENSMUSG00000019883.4 799.9924539 -1.590175706 0.405013436 -3.926229511 8.63E-05 0.005426796 10.21362057 8.579036739 8 Ecm1 ENSMUSG00000028108.8 2502.760239 1.009499902 0.32259766 3.129284637 0.001752325 0.049722952 10.61614639 11.77277653 8 Ecscr ENSMUSG00000073599.3 31.18851968 1.833526935 0.464817437 3.944617372 7.99E-05 0.005195933 5.726389147 6.758926862 8 Efnb2 ENSMUSG00000001300.8 1477.616306 1.120175143 0.304188891 3.682498528 0.000230959 0.011189998 9.844732039 11.06337634 8 Ehd4 ENSMUSG00000027293.7 755.338874 0.933872973 0.292617239 3.191448927 0.001415611 0.041893953 9.126884638 10.05312851 8 Elmo1 ENSMUSG00000041112.7 224.8598329 1.20913424 0.347681293 3.477708647 0.000505719 0.020056232 7.480375048 8.595587687 8 Emilin2 ENSMUSG00000024053.9 98.06749991 -1.308359716 0.3842485 -3.404983275 0.000661681 0.024511284 7.667044246 6.681589182 8 Eml5 ENSMUSG00000051166.8 236.9597642 -1.347171828 0.38636474 -3.486787714 0.000488859 0.019650734 8.635638709 7.434923538 8 Entpd5 ENSMUSG00000021236.10 1172.529901 -1.202703856 0.354594261 -3.391774738 0.000694415 0.025384127 10.70124376 9.459223543 8 Epas1 ENSMUSG00000024140.9 1731.140307 -1.637322714 0.333140772 -4.914807345 8.89E-07 0.000145519 11.38874683 9.645494458 8 Epb4.1l4a ENSMUSG00000024376.6 271.2379046 1.016891942 0.315947697 3.218545196 0.001288427 0.039680389 7.829872725 8.756627119 8 Ets2 ENSMUSG00000022895.8 2498.818207 1.055659019 0.303759084 3.475316699 0.000510251 0.020167875 10.6278303 11.7625353 8 Extl3 ENSMUSG00000021978.7 5012.95624 -0.975679506 0.303832645 -3.211239883 0.001321636 0.039971704 12.70771496 11.67807098 8 F13a1 ENSMUSG00000039109.8 157.4825074 -1.773429654 0.431896758 -4.106142545 4.02E-05 0.003183627 8.215293621 6.72677364 8 F830016B08Rik ENSMUSG00000090942.1 151.837728 1.835874184 0.436014551 4.210580084 2.55E-05 0.00223606 6.576883366 8.306335499 8 Fabp4 ENSMUSG00000062515.2 36944.63506 -1.742187238 0.480208027 -3.627984417 0.000285642 0.013190423 15.36526618 13.20387855 8 Fabp5 ENSMUSG00000027533.9 6215.961965 -1.784598407 0.436245404 -4.090813087 4.30E-05 0.003354328 13.03350307 11.00568686 8 Fam110c ENSMUSG00000036136.8 464.7044376 -1.695863858 0.454826634 -3.728593995 0.000192551 0.009864585 9.399023472 7.704596482 8 Fam126b ENSMUSG00000038174.8 947.626535 -1.231665666 0.369891233 -3.329804968 0.000869068 0.029532554 10.40246504 9.14137807 8 Fam171b ENSMUSG00000048388.3 534.8112198 1.165825175 0.352349021 3.308722617 0.000937226 0.03140547 8.4399696 9.698681035 8 Fam195a ENSMUSG00000025732.5 452.8465883 -1.494311003 0.454910846 -3.284843649 0.00102039 0.033656888 9.33355117 7.840882893 8 Fam20a ENSMUSG00000020614.7 394.5024035 1.011556668 0.289449163 3.494764534 0.00047448 0.019321887 8.270570402 9.2317062 8 Fam40b ENSMUSG00000039629.8 773.4660336 -1.219377861 0.33533027 -3.636348911 0.00027653 0.012875437 10.15278814 8.931023526 8 Fam69a ENSMUSG00000029270.4 1505.264014 -1.15184326 0.334072736 -3.447881663 0.000565002 0.021892185 11.04861738 9.852367679 8 Fam83a ENSMUSG00000051225.3 718.837534 -1.876167684 0.483315603 -3.88186864 0.000103657 0.006284664 9.835748463 7.781973142 8 Fam84b ENSMUSG00000072568.3 9.300932107 1.584539763 0.499709096 3.170924394 0.001519547 0.044465213 5.120768005 6.05496686 8 Fgf1 ENSMUSG00000036585.9 50.75701245 -1.660470595 0.496121735 -3.346901531 0.000817202 0.028283255 7.036794794 5.859433199 8 Fgf14 ENSMUSG00000025551.7 58.78737962 1.267661302 0.396158671 3.199882759 0.001374835 0.041159581 6.338405268 7.176267886 8 Fgfr3 ENSMUSG00000054252.9 311.5653256 -1.273914705 0.320840836 -3.970550383 7.17E-05 0.004837326 9.01366098 7.808461694 8 Fgfrl1 ENSMUSG00000008090.8 5211.719775 -0.984813415 0.281891623 -3.493588798 0.000476574 0.019355813 12.77773829 11.73864704 8 Fhod3 ENSMUSG00000034295.8 64.76037555 1.961609912 0.405546511 4.836954229 1.32E-06 0.000198413 6.102755411 7.381960242 8 Fibin ENSMUSG00000074971.3 424.1341482 1.424790451 0.352359566 4.043569662 5.26E-05 0.003961189 7.995133948 9.464590316 8 Fitm2 ENSMUSG00000048486.6 3814.280685 -1.510104008 0.426234014 -3.542898878 0.000395754 0.016634516 12.32828842 10.63184756 8 Fmo1 ENSMUSG00000040181.8 165.9013716 -1.631825217 0.475497179 -3.431829441 0.000599524 0.022965875 8.137135372 6.705297449 8 Foxg1 ENSMUSG00000020950.8 15.96999662 2.022617955 0.505254067 4.00317006 6.25E-05 0.004384834 5.300989226 6.349423017 8 Foxp2 ENSMUSG00000029563.10 24.01890445 2.185998227 0.488358238 4.476218597 7.60E-06 0.000815661 5.468018498 6.612570988 8 Frat2 ENSMUSG00000047604.2 195.6880036 -1.697998059 0.443456852 -3.829003993 0.000128663 0.007401411 8.412766348 6.919858567 8 Fsd2 ENSMUSG00000038663.7 96.30539997 -2.010976343 0.49648367 -4.050438039 5.11E-05 0.003881346 7.561235281 5.981304469 8 Fzd4 ENSMUSG00000049791.3 1614.821108 -1.132642165 0.295098464 -3.83818387 0.000123948 0.007179168 11.16279798 9.992866169 8 Gadd45b ENSMUSG00000015312.8 189.7844383 1.042078767 0.32591856 3.197359385 0.00138692 0.041301305 7.436330142 8.338548097 8 Gale ENSMUSG00000028671.10 546.7367209 -1.547001401 0.415698886 -3.721447067 0.000198084 0.010056363 9.701974257 8.120603601 8 Gap43 ENSMUSG00000047261.9 37.61588194 2.407626428 0.470841782 5.1134511 3.16E-07 6.66E-05 5.572194599 6.96829948 8 Gas2l2 ENSMUSG00000020686.6 15.53539405 -1.694023521 0.50635912 -3.345498193 0.000821349 0.028355094 6.310358765 5.223603993 8 Gbp1 ENSMUSG00000028269.4 74.69005998 1.301170077 0.382135676 3.404995024 0.000661653 0.024511284 6.494264556 7.40095518 8 Gbp10 ENSMUSG00000054588.7 2026.202105 1.382570301 0.30687967 4.505252181 6.63E-06 0.00072372 10.09907469 11.55400357 8 Gbp11 ENSMUSG00000092021.1 252.8417002 1.438012507 0.328270642 4.380569936 1.18E-05 0.001194679 7.489001907 8.791841401 8 Gbp3 ENSMUSG00000028268.8 920.6727592 1.920996285 0.334375268 5.745031014 9.19E-09 4.77E-06 8.603731631 10.57364913 8 Gbp4 ENSMUSG00000079363.2 452.1841702 2.214899015 0.33853699 6.542561314 6.05E-11 6.37E-08 7.54698806 9.701341268 8 Gbp5 ENSMUSG00000040264.7 28.70123557 2.268343507 0.485874744 4.668576699 3.03E-06 0.000391545 5.497862193 6.737396513 8 Gbp6 ENSMUSG00000079362.2 2712.496473 1.343881586 0.296718229 4.529150741 5.92E-06 0.00067903 10.54071646 11.95769266 8 Gbp7 ENSMUSG00000040253.9 1436.442909 1.321794205 0.371954521 3.553644681 0.000379932 0.016171102 9.520136455 11.09695638 8 Gbp8 ENSMUSG00000034438.9 321.7755496 1.832462026 0.344573734 5.318054869 1.05E-07 3.25E-05 7.451838981 9.19009196 8 Gbp9 ENSMUSG00000029298.8 741.6813397 2.220830142 0.39629589 5.603969655 2.09E-08 8.21E-06 7.871174366 10.40195336 8 Gchfr ENSMUSG00000046814.3 353.8355138 -1.628023193 0.486169985 -3.348670716 0.000812002 0.028161111 8.881962693 7.299218475 8 Gda ENSMUSG00000058624.6 1132.976316 -1.188541407 0.325492121 -3.651521286 0.000260691 0.012278791 10.68860913 9.438650629 8 Gdap10 ENSMUSG00000059937.7 127.7227014 -1.194588404 0.369720643 -3.231056813 0.001233334 0.038567437 7.919412507 6.965215922 8 Gdap1l1 ENSMUSG00000017943.9 71.02544264 1.552344218 0.474529473 3.271333618 0.001070416 0.034762724 6.136186139 7.42567431 8 Gdf10 ENSMUSG00000021943.5 43.5167459 -2.068108372 0.498127144 -4.151768075 3.30E-05 0.002766539 7.006204606 5.595912346 8 Gdf5 ENSMUSG00000038259.3 133.1872392 -1.827929007 0.440771141 -4.147115896 3.37E-05 0.002809358 8.048420663 6.534511423 8 Gja1 ENSMUSG00000050953.8 957.8058 1.809120711 0.353527436 5.117341766 3.10E-07 6.66E-05 8.655087392 10.65522492 8 Gm10053 ENSMUSG00000058927.4 1807.224597 -1.376983032 0.434485539 -3.169226381 0.001528453 0.04464831 11.2011724 9.733554821 8 Gm10108 ENSMUSG00000062038.3 1843.031832 -1.382118459 0.434344502 -3.182078861 0.00146222 0.043162378 11.22958873 9.755961947 8 Gm10121 ENSMUSG00000062813.6 921.883093 -1.396566497 0.434781894 -3.212108223 0.001317647 0.039944941 10.29172485 8.83694628 8 Gm10687 ENSMUSG00000074408.2 134.600422 -1.636666524 0.476143262 -3.437340513 0.000587457 0.022606348 7.920627642 6.547978369 8 Gm11618 ENSMUSG00000083991.1 195.0496965 -1.601100198 0.482228307 -3.320211972 0.000899491 0.030491132 8.262624104 6.819972779 8 Gm11625 ENSMUSG00000080839.1 421.1699519 -1.388934452 0.433880296 -3.201192739 0.0013686 0.041118975 9.280702382 7.91567234 8 Gm12185 ENSMUSG00000048852.7 86.50682123 1.750117111 0.393720902 4.44507036 8.79E-06 0.000919834 6.376049474 7.631569004 8 Gm12222 ENSMUSG00000060068.6 339.3395828 -1.698473668 0.42109907 -4.033430108 5.50E-05 0.003993511 9.110276682 7.484776356 8 Gm12250 ENSMUSG00000082292.2 238.9526973 2.860627667 0.423838168 6.749339455 1.49E-11 2.09E-08 6.391554233 8.886677745 8 Gm12505 ENSMUSG00000087070.1 24.0202607 -1.870992725 0.506337763 -3.695147512 0.000219759 0.01073635 6.533429199 5.394272221 Page 75 of 79 Diabetes
8 Gm13252 ENSMUSG00000084105.1 205.0653841 -1.439026117 0.445851515 -3.227590506 0.001248375 0.038750217 8.405337501 7.127689261 8 Gm13502 ENSMUSG00000083287.2 2053.404403 -1.329289726 0.337310243 -3.940851935 8.12E-05 0.005243309 11.53884507 10.12637369 8 Gm13772 ENSMUSG00000080977.1 1076.114351 -1.379803225 0.436808961 -3.158825366 0.001584064 0.045796561 10.48873992 9.041581277 8 Gm13910 ENSMUSG00000063684.7 1824.231703 -1.394766068 0.418710214 -3.331101135 0.000865032 0.029454766 11.27162678 9.768418643 8 Gm13998 ENSMUSG00000081056.1 143.6574836 -1.53876914 0.449705491 -3.421726374 0.000622249 0.023515711 8.04872542 6.743228612 8 Gm14328 ENSMUSG00000082401.1 472.520397 -1.618165075 0.431813447 -3.747370737 0.000178698 0.009412352 9.478564939 7.869408271 8 Gm14446 ENSMUSG00000079339.6 93.75976485 2.270438363 0.444962037 5.102543981 3.35E-07 6.97E-05 6.064056654 7.790508228 8 Gm15433 ENSMUSG00000073632.3 268.7703707 2.217088574 0.399209891 5.553691496 2.80E-08 1.02E-05 6.914857058 9.029668494 8 Gm15753 ENSMUSG00000082088.1 31.10768695 1.906785192 0.472473753 4.035748401 5.44E-05 0.003985605 5.676062638 6.770335743 8 Gm16026 ENSMUSG00000079455.2 94.2186152 1.631616405 0.403124646 4.047424097 5.18E-05 0.003914016 6.455460715 7.717244512 8 Gm16163 ENSMUSG00000090118.1 43.48283866 -1.901149816 0.506479973 -3.753652495 0.000174276 0.009266338 6.846294325 5.440366083 8 Gm16332 ENSMUSG00000089991.1 190.455061 2.218385145 0.449171886 4.938833473 7.86E-07 0.000134145 6.474608092 8.588793195 8 Gm16439 ENSMUSG00000072594.3 567.5086359 -1.818507695 0.478792746 -3.79811037 0.000145803 0.008164506 9.522802087 7.667845604 8 Gm16854 ENSMUSG00000085607.1 1947.796726 -1.891150798 0.427604976 -4.422658542 9.75E-06 0.001001563 11.4437702 9.355376473 8 Gm20419 ENSMUSG00000092215.1 260.471568 -1.860999461 0.438002269 -4.248835202 2.15E-05 0.00194725 8.79432437 7.063903079 8 Gm2619 ENSMUSG00000091199.1 151.0394873 2.032023723 0.406281417 5.00151776 5.69E-07 0.000105354 6.560554669 8.312211971 8 Gm2635 ENSMUSG00000089763.1 172.2111172 2.163394496 0.419938961 5.151687976 2.58E-07 5.96E-05 6.538814029 8.490779963 8 Gm2666 ENSMUSG00000090189.3 195.3851958 2.077106422 0.430156997 4.828717042 1.37E-06 0.000204968 6.642242877 8.632127906 8 Gm4070 ENSMUSG00000078606.1 2682.797946 1.909696457 0.442343575 4.317224359 1.58E-05 0.0015218 9.397055629 12.17973338 8 Gm4788 ENSMUSG00000070594.4 206.7099931 2.282194826 0.457462237 4.98881578 6.08E-07 0.000108931 6.438901631 8.708556217 8 Gm4902 ENSMUSG00000091649.1 136.9250381 2.040605894 0.398900873 5.115571385 3.13E-07 6.66E-05 6.519270133 8.179671544 8 Gm4951 ENSMUSG00000073555.1 516.8507674 1.773928431 0.420641035 4.217202519 2.47E-05 0.002182783 7.780414505 9.782521135 8 Gm5514 ENSMUSG00000045104.8 247.5332366 -1.62723711 0.391837617 -4.152835354 3.28E-05 0.002766539 8.753185975 7.285084545 8 Gm6166 ENSMUSG00000074280.4 3301.270431 -1.79631446 0.438798075 -4.093715451 4.25E-05 0.003329436 12.1334278 10.1024831 8 Gm6907 ENSMUSG00000091144.1 144.6410509 1.309492781 0.389719914 3.360086909 0.00077918 0.027576167 6.981902529 8.082311894 8 Gm7582 ENSMUSG00000061852.8 203.7960434 1.890351699 0.420570177 4.494735489 6.97E-06 0.000752603 6.818351533 8.654709997 8 Gm7592 ENSMUSG00000090186.3 877.0851412 2.0937364 0.41473205 5.048407523 4.46E-07 8.83E-05 8.085331836 10.60250181 8 Gm7609 ENSMUSG00000079457.3 423.7196407 2.059175285 0.414917974 4.962849076 6.95E-07 0.000121964 7.359986188 9.612694544 8 Gm8979 ENSMUSG00000091928.1 283.1853105 2.094666937 0.418260808 5.008040195 5.50E-07 0.000103172 6.971744156 9.081315517 8 Gm8989 ENSMUSG00000091567.1 283.1853105 2.094666937 0.418260808 5.008040195 5.50E-07 0.000103172 6.971744156 9.081315517 8 Gnb4 ENSMUSG00000027669.6 322.9909258 1.072232321 0.341528655 3.139509102 0.001692312 0.048182283 7.947766184 9.006421685 8 Gnpat ENSMUSG00000031985.3 5665.213551 -1.56063949 0.435111088 -3.586761024 0.000334811 0.014679241 12.86300238 11.11004591 8 Gpr116 ENSMUSG00000056492.4 79.71657347 -1.926410564 0.496123934 -3.882922049 0.000103209 0.006280079 7.442632925 5.914676971 8 Gpr126 ENSMUSG00000039116.4 241.0097352 1.826620239 0.33206197 5.500841419 3.78E-08 1.36E-05 7.204315455 8.817693557 8 Gpr176 ENSMUSG00000040133.2 224.5706423 1.359667371 0.366580666 3.70905369 0.000208035 0.010252735 7.379118662 8.61551836 8 Gprc5b ENSMUSG00000008734.8 3998.246761 -1.075037499 0.309508995 -3.473364322 0.000513977 0.020240853 12.41607168 11.28097842 8 Gprc5c ENSMUSG00000051043.8 68.89762164 -1.886698082 0.451532297 -4.1784344 2.94E-05 0.002537089 7.38931739 6.089022495 8 Grhl1 ENSMUSG00000020656.9 144.4372736 -1.623797887 0.425595513 -3.815354809 0.000135987 0.007691502 8.124508469 6.741416525 8 Gsdmd ENSMUSG00000022575.4 182.0312399 1.999184403 0.359368279 5.563051946 2.65E-08 9.93E-06 6.821682418 8.510863979 8 Gstz1 ENSMUSG00000021033.9 3712.913959 -1.951500191 0.446903413 -4.366715794 1.26E-05 0.001260679 12.2809419 10.06302787 8 Gvin1 ENSMUSG00000045868.5 2633.303229 1.909784617 0.441943298 4.321334038 1.55E-05 0.00150231 9.376517419 12.15323114 8 Hadhb ENSMUSG00000059447.7 5032.808121 -1.379668266 0.413969916 -3.332774225 0.000859847 0.029337488 12.71034121 11.1905436 8 Hao1 ENSMUSG00000027261.2 25.32323031 -1.653144976 0.506665351 -3.262794612 0.001103194 0.035485385 6.500791152 5.498860968 8 Hap1 ENSMUSG00000006930.8 21.93995648 1.710420742 0.489033428 3.497553834 0.000469546 0.019209215 5.587111633 6.50274358 8 Hbegf ENSMUSG00000024486.5 92.48180648 1.635606321 0.453994828 3.602698137 0.000314931 0.01411746 6.307795447 7.724404538 8 Hdhd3 ENSMUSG00000038422.2 397.2887257 -1.447846673 0.439697256 -3.292826267 0.000991857 0.032844316 9.200506948 7.795478019 8 Herc6 ENSMUSG00000029798.8 728.9053438 1.518113391 0.377525547 4.021220296 5.79E-05 0.004170347 8.492297314 10.21765681 8 Hhip ENSMUSG00000064325.3 20.46792888 1.846408854 0.503938782 3.663954668 0.000248351 0.011891909 5.406581305 6.482459874 8 Hibch ENSMUSG00000041426.6 1900.217149 -1.687328121 0.444362044 -3.797192276 0.000146344 0.008167658 11.32073901 9.445963617 8 Hipk2 ENSMUSG00000061436.8 5280.199591 -2.147875309 0.337881149 -6.356895948 2.06E-10 1.65E-07 13.08539644 10.69362637 8 Hoxd3 ENSMUSG00000079277.2 443.1239409 -0.908780291 0.278716262 -3.260592995 0.001111795 0.035626055 9.34846084 8.477731162 8 Hs6st2 ENSMUSG00000062184.5 784.1033898 1.279095236 0.349307919 3.661798559 0.000250451 0.011949733 8.838602661 10.2359927 8 Hsd11b1 ENSMUSG00000016194.8 3920.609884 -2.882564891 0.435751938 -6.615151049 3.71E-11 4.81E-08 12.54282202 9.138938563 8 Hsdl2 ENSMUSG00000028383.10 1379.496991 -1.171544076 0.360523519 -3.249563526 0.001155823 0.036826824 10.9056913 9.696326691 8 I830012O16Rik ENSMUSG00000062488.8 2813.646405 2.140833857 0.454160886 4.713822623 2.43E-06 0.000325211 9.169046916 12.19335488 8 Iars ENSMUSG00000037851.7 3252.687059 0.848026486 0.255539158 3.318577445 0.000904772 0.030560996 11.18086268 12.06750183 8 Id1 ENSMUSG00000042745.9 901.8309941 -0.897560669 0.276963235 -3.240721352 0.001192277 0.037562286 10.28706484 9.387520651 8 Idh1 ENSMUSG00000025950.9 9722.540498 -1.133269575 0.332018736 -3.413269954 0.000641883 0.024042094 13.68989531 12.47623752 8 Idh3a ENSMUSG00000032279.9 3521.343789 -1.505293774 0.443431891 -3.394644824 0.000687177 0.025179056 12.13004261 10.4852206 8 Idi1 ENSMUSG00000058258.6 2302.359384 -1.345552302 0.340981287 -3.946117732 7.94E-05 0.005189025 11.70307728 10.26377827 8 Ifi205 ENSMUSG00000054203.6 193.7043756 1.399974263 0.414314282 3.37901522 0.00072746 0.026311878 7.113623632 8.464222834 8 Ifi27l2a ENSMUSG00000079017.3 535.9228776 1.605618738 0.284813461 5.6374398 1.73E-08 7.69E-06 8.251514437 9.790266874 8 Ifi35 ENSMUSG00000010358.7 789.6223733 1.270519125 0.327142044 3.883692572 0.000102882 0.006280079 8.915236544 10.21512822 8 Ifi44 ENSMUSG00000028037.7 1424.266933 2.014396927 0.466906267 4.314349733 1.60E-05 0.001532975 8.258720264 11.32182978 8 Ifi47 ENSMUSG00000078920.2 488.6223982 1.8895742 0.411909369 4.587354265 4.49E-06 0.000540442 7.646311378 9.762144416 8 Ifih1 ENSMUSG00000026896.7 408.5488639 1.567760701 0.373423578 4.198344169 2.69E-05 0.002348118 7.840251977 9.417728461 8 Ifit1 ENSMUSG00000034459.8 2406.060889 2.427949344 0.4619225 5.256183333 1.47E-07 4.06E-05 8.532211796 12.04709523 8 Ifit2 ENSMUSG00000045932.6 762.2299599 1.533531881 0.385373575 3.979338439 6.91E-05 0.004728764 8.506449907 10.28880144 8 Ifit3 ENSMUSG00000074896.3 3587.402234 2.248569806 0.459121772 4.897545578 9.70E-07 0.000155774 9.290685159 12.5579895 8 Igf2 ENSMUSG00000048583.9 2842.823234 -1.396801874 0.432524554 -3.229416368 0.001240432 0.0386462 11.95409576 10.232157 8 Igfals ENSMUSG00000046070.7 318.1096222 -1.533486991 0.401097844 -3.823224219 0.000131718 0.007475102 9.034667059 7.573993517 8 Igfbp5 ENSMUSG00000026185.8 302.6138064 2.003832157 0.3906323 5.129714454 2.90E-07 6.52E-05 7.19067777 9.127919593 8 Igtp ENSMUSG00000078853.2 1074.594394 2.21622166 0.394359517 5.619800114 1.91E-08 7.69E-06 8.342325638 10.85485628 8 Il13ra1 ENSMUSG00000017057.8 474.2200255 1.459617496 0.361615096 4.036384302 5.43E-05 0.003985605 8.075096332 9.624714958 8 Il2ra ENSMUSG00000026770.4 121.3605554 -1.710407919 0.404399609 -4.229499441 2.34E-05 0.002077706 7.952080881 6.619176608 8 Il31ra ENSMUSG00000050377.6 90.3161572 1.328724595 0.370609404 3.585242524 0.000336765 0.014686955 6.62003447 7.598511961 8 Inhbb ENSMUSG00000037035.5 799.1916558 -1.960374596 0.47523224 -4.12508755 3.71E-05 0.003017564 10.00894703 7.922491335 8 Insc ENSMUSG00000048782.8 10.60292418 1.866736524 0.501560034 3.721860591 0.00019776 0.010056363 4.995335464 6.13483442 8 Insig1 ENSMUSG00000045294.9 9174.990362 -2.02004341 0.386359292 -5.228406433 1.71E-07 4.45E-05 13.79881958 11.46111344 8 Irf4 ENSMUSG00000021356.3 17.63917372 -1.612505167 0.503902316 -3.200035239 0.001374108 0.041159581 6.335129141 5.223603993 8 Irf7 ENSMUSG00000025498.7 798.1705665 1.887215094 0.365116146 5.168807554 2.36E-07 5.75E-05 8.408043838 10.34183336 8 Irf9 ENSMUSG00000002325.8 1364.687035 1.310945869 0.335061739 3.912550189 9.13E-05 0.005701144 9.55263729 11.00890204 8 Irgm1 ENSMUSG00000046879.5 1698.075113 1.891185862 0.388106615 4.872851393 1.10E-06 0.00016703 9.216233298 11.44455422 8 Irgm2 ENSMUSG00000069874.5 1619.729511 1.989185653 0.402657491 4.940143169 7.81E-07 0.000134145 8.995110629 11.40531584 8 Irx1 ENSMUSG00000060969.7 1016.846574 1.07435261 0.27627804 3.888664512 0.000100797 0.006200508 9.421975841 10.51590875 8 Isg15 ENSMUSG00000035692.6 1417.046456 2.16496708 0.441923802 4.898960117 9.63E-07 0.000155774 8.418927695 11.24211997 Diabetes Page 76 of 79
8 Itga3 ENSMUSG00000001507.9 190.4744485 1.365005622 0.335749652 4.0655459 4.79E-05 0.003688102 7.251450837 8.429996231 8 Itgbl1 ENSMUSG00000032925.9 2342.034729 1.372108575 0.267348643 5.132281794 2.86E-07 6.52E-05 10.32958728 11.77873418 8 Itih4 ENSMUSG00000021922.9 347.5123232 -2.303513261 0.487881869 -4.721456986 2.34E-06 0.000315743 9.031083876 6.61971288 8 Ivd ENSMUSG00000027332.5 4689.444004 -1.435726744 0.411149989 -3.491978069 0.000479458 0.019377586 12.61501475 11.06230191 8 Iyd ENSMUSG00000019762.4 16.32978853 1.881471732 0.506672404 3.713389004 0.000204502 0.010199493 5.217299794 6.364217864 8 Jak3 ENSMUSG00000031805.10 714.7723951 -1.09116145 0.293460494 -3.718256704 0.000200602 0.010103363 10.03092026 8.949771489 8 Jazf1 ENSMUSG00000063568.5 32.34591788 -1.628058934 0.483498063 -3.367250168 0.000759218 0.027047183 6.746611367 5.752374954 8 Jhdm1d ENSMUSG00000042599.8 2524.577174 -0.917009102 0.285020037 -3.217349604 0.001293808 0.039721567 11.72283662 10.76713152 8 Jmjd8 ENSMUSG00000025736.8 349.612027 -1.342435344 0.354201631 -3.790031517 0.000150628 0.00835144 9.156717531 7.866921162 8 Jub ENSMUSG00000022178.9 665.5698993 0.956771194 0.285186686 3.354894322 0.000793953 0.027706168 8.952834064 9.894644471 8 Kank1 ENSMUSG00000032702.9 729.8476288 -1.498948466 0.425887801 -3.519585351 0.000432222 0.017987903 10.02076622 8.495130139 8 Kbtbd11 ENSMUSG00000055675.5 55.5629162 -1.76899049 0.495340309 -3.571262946 0.000355264 0.015294258 7.096189632 5.873108802 8 Kcnh2 ENSMUSG00000038319.8 41.77515327 -1.930107687 0.486239532 -3.969458587 7.20E-05 0.004837326 6.945632027 5.738680056 8 Kcnj2 ENSMUSG00000041695.2 24.94954481 2.560467088 0.505172224 5.068503304 4.01E-07 8.14E-05 5.123822884 6.639594957 8 Kcnk3 ENSMUSG00000049265.6 1002.352266 -1.737332391 0.471791797 -3.682413307 0.000231036 0.011189998 10.31085453 8.431558876 8 Kcnt2 ENSMUSG00000052726.9 164.985224 2.065019835 0.392607098 5.259761852 1.44E-07 4.05E-05 6.647099963 8.402457057 8 Kctd12b ENSMUSG00000041633.8 607.0171633 -1.349203713 0.339107876 -3.978685869 6.93E-05 0.004728764 9.868446226 8.528434948 8 Kctd14 ENSMUSG00000051727.8 59.58947071 -1.459460588 0.432560817 -3.374000907 0.000740841 0.026624476 7.208835062 6.230040846 8 Kif21a ENSMUSG00000022629.9 673.8161394 -1.01448492 0.322721517 -3.143530467 0.00166923 0.047686234 9.913320164 8.908757731 8 Kif21b ENSMUSG00000041642.11 567.6933067 1.009927892 0.296951402 3.40098711 0.00067143 0.024817876 8.703756815 9.706538751 8 Klra2 ENSMUSG00000030187.9 71.68353535 -1.549221326 0.483851243 -3.201854592 0.001365459 0.041097879 7.305203062 6.169121254 8 Krt15 ENSMUSG00000054146.7 25.56939762 2.083324159 0.497249502 4.18969582 2.79E-05 0.002426848 5.433458899 6.660217208 8 Krt36 ENSMUSG00000020916.8 37.02494981 -1.947548503 0.499851697 -3.896252657 9.77E-05 0.006053701 6.821627151 5.603402386 8 Lama5 ENSMUSG00000015647.8 228.1818996 1.597429259 0.33815205 4.723996969 2.31E-06 0.000315256 7.280185551 8.704910847 8 Lbh ENSMUSG00000024063.6 5746.710187 1.108033109 0.349062465 3.174311826 0.001501922 0.044102617 11.64523294 13.00142478 8 Lctl ENSMUSG00000032401.9 153.9502456 -1.846719592 0.488352671 -3.781528601 0.000155868 0.008529741 8.023494913 6.429139485 8 Ldhb ENSMUSG00000030246.5 2270.88334 -1.564669289 0.358356348 -4.366238511 1.26E-05 0.001260679 11.71618183 10.04631795 8 Ldlr ENSMUSG00000032193.7 2010.955307 -1.104990369 0.323676309 -3.413874721 0.00064046 0.024042094 11.44626544 10.29028818 8 Lep ENSMUSG00000059201.6 118.1871156 -1.820390971 0.506516157 -3.593944526 0.000325709 0.014446918 7.540186131 5.969969058 8 Lfng ENSMUSG00000029570.1 791.0396221 -1.780543822 0.447334959 -3.980336848 6.88E-05 0.004728764 10.12012599 8.262059954 8 Lgals9 ENSMUSG00000001123.9 2542.158258 1.22535713 0.322199649 3.803098897 0.000142897 0.008028445 10.48160363 11.8572405 8 Lias ENSMUSG00000029199.5 1300.613569 -1.102301286 0.33501046 -3.290348861 0.001000632 0.03306992 10.8275011 9.694353927 8 Lipe ENSMUSG00000003123.9 12811.29715 -1.747586424 0.467631896 -3.737098431 0.000186156 0.009601691 13.92476056 11.84447194 8 Lpcat3 ENSMUSG00000004270.7 5693.464105 -1.24872331 0.390315852 -3.19926363 0.001377791 0.041174947 12.9043988 11.52781057 8 Lpin1 ENSMUSG00000020593.7 3627.60052 -1.685744555 0.452443833 -3.725864805 0.000194647 0.009941728 12.20015025 10.26512541 8 Lpl ENSMUSG00000015568.8 125316.6275 -1.629133847 0.430986922 -3.780007617 0.000156824 0.008554243 17.34298468 15.48029465 8 Lrg1 ENSMUSG00000037095.7 139.6486616 -1.776445835 0.479811632 -3.702381763 0.000213585 0.01049555 8.026089619 6.428154225 8 Lrig1 ENSMUSG00000030029.7 12068.87357 -1.661752043 0.390957554 -4.250466646 2.13E-05 0.001943569 14.07709565 12.22208697 8 Lrrc39 ENSMUSG00000027961.5 269.8513156 -1.67150041 0.442640663 -3.776201667 0.000159238 0.00863009 8.793300656 7.213733675 8 Lrtm1 ENSMUSG00000045776.2 113.9725855 -2.283564655 0.498841348 -4.577737317 4.70E-06 0.000561872 7.711946474 5.873108802 8 Ltc4s ENSMUSG00000020377.8 364.140569 -1.763724725 0.47142176 -3.74128832 0.000183079 0.009553568 9.051230675 7.305358623 8 Lum ENSMUSG00000036446.4 3174.231041 -1.055999828 0.303526639 -3.479100986 0.000503099 0.01999937 12.08542693 10.97570746 8 Ly6a ENSMUSG00000075602.4 765.3240016 1.138138225 0.306115941 3.717997245 0.000200808 0.010103363 8.972587296 10.15864041 8 Ly6e ENSMUSG00000022587.7 2817.874356 0.875124395 0.241530629 3.623243974 0.000290931 0.013325122 10.9669568 11.87655049 8 Ly6h ENSMUSG00000022577.9 157.692139 -2.131871712 0.433775935 -4.914684145 8.89E-07 0.000145519 8.294354703 6.495045533 8 Maoa ENSMUSG00000025037.6 1957.046299 0.847458456 0.258709498 3.275714512 0.00105395 0.034427004 10.46892043 11.35276162 8 Marco ENSMUSG00000026390.1 24.51091008 -1.561997427 0.497350011 -3.14064018 0.00168579 0.048077821 6.548365315 5.619767633 8 Masp1 ENSMUSG00000022887.7 545.1158604 1.027618189 0.264490932 3.885268134 0.000102217 0.006264973 8.667078441 9.657216318 8 Mc2r ENSMUSG00000045569.6 304.1847704 -1.739430026 0.46107398 -3.772561679 0.00016158 0.008728945 8.887621789 7.206063827 8 Mcam ENSMUSG00000032135.8 2814.795741 -1.690459367 0.462960321 -3.651413071 0.000260801 0.012278791 11.78397249 9.853174276 8 Mcoln2 ENSMUSG00000011008.7 50.42452521 -1.669511301 0.491276642 -3.398311982 0.000678031 0.024952411 7.078142697 5.863399407 8 Mctp1 ENSMUSG00000021596.9 48.22673174 1.644122546 0.470911125 3.491364842 0.00048056 0.019377586 5.924354148 7.098563921 8 Mdh1 ENSMUSG00000020321.9 8486.085524 -1.414320418 0.400720826 -3.529440761 0.000416439 0.017417067 13.47976758 11.9438454 8 Mest ENSMUSG00000051855.8 845.0718552 -1.722712574 0.438746661 -3.926440307 8.62E-05 0.005426796 10.33522076 8.342410324 8 Mfap2 ENSMUSG00000060572.10 95.57310129 -1.449163054 0.361807226 -4.005345797 6.19E-05 0.004373188 7.679042142 6.618809214 8 Mgst1 ENSMUSG00000008540.5 12511.93969 -1.209072392 0.311782163 -3.877939589 0.000105345 0.006364114 14.0917164 12.79365665 8 Mgst3 ENSMUSG00000026688.5 2148.624869 -1.271993735 0.398592447 -3.191213847 0.001416764 0.041893953 11.49707592 10.15589005 8 Mid2 ENSMUSG00000000266.5 455.0586014 1.864188022 0.283924821 6.565780397 5.18E-11 6.23E-08 7.890490249 9.629761968 8 Mlph ENSMUSG00000026303.6 81.76727316 -1.526880546 0.386161014 -3.953999729 7.69E-05 0.005079998 7.532313666 6.451025476 8 Mmab ENSMUSG00000029575.10 1787.508501 -1.21193758 0.326172959 -3.715628614 0.000202699 0.010168136 11.31124085 10.04774854 8 Mmd ENSMUSG00000003948.9 6903.218915 -1.866341582 0.431749936 -4.322737369 1.54E-05 0.001501412 13.21412891 11.08649153 8 Mndal ENSMUSG00000090272.1 711.2461278 1.382475721 0.432202961 3.198672489 0.001380619 0.041186435 8.376201113 10.1507103 8 Mpeg1 ENSMUSG00000046805.9 37.43784556 1.639795759 0.450057484 3.643525147 0.000268929 0.012591123 5.896935043 6.864545137 8 Mtap1b ENSMUSG00000052727.4 476.0800982 1.874650874 0.286086574 6.55273978 5.65E-11 6.35E-08 7.929660999 9.693439999 8 Mthfd1l ENSMUSG00000040675.11 823.5633638 1.090593561 0.318126151 3.428179536 0.000607643 0.023171562 9.104582043 10.22288878 8 Mx1 ENSMUSG00000000386.8 772.194708 2.682559826 0.467599527 5.736874544 9.64E-09 4.77E-06 7.057342366 10.45206722 8 Mx2 ENSMUSG00000023341.8 717.665345 2.136528934 0.479696309 4.453919896 8.43E-06 0.000888222 7.340310343 10.26653804 8 Myo7a ENSMUSG00000030761.9 979.41646 0.865650052 0.256873545 3.369946305 0.000751828 0.026904599 9.522923249 10.39583694 8 N4bp2l1 ENSMUSG00000041132.8 526.8585383 -1.335728217 0.4050711 -3.297515464 0.000975443 0.03242819 9.607353248 8.2770582 8 Naaa ENSMUSG00000029413.7 4306.674899 -1.443728111 0.402558715 -3.586378975 0.000335302 0.014679241 12.51915318 10.95332894 8 Naip5 ENSMUSG00000071203.5 217.9667927 1.206893266 0.369439028 3.266826661 0.001087603 0.035117893 7.418597624 8.562550183 8 Napepld ENSMUSG00000044968.9 503.5994772 -1.433902273 0.351267106 -4.082085248 4.46E-05 0.003466803 9.633051979 8.233535445 8 Nckap5 ENSMUSG00000049690.8 169.7737315 1.268543401 0.322522816 3.93318965 8.38E-05 0.005331653 7.213385657 8.267430094 8 Ndn ENSMUSG00000033585.4 1993.691744 1.193153097 0.288473995 4.136085467 3.53E-05 0.002904656 10.21872487 11.50200182 8 Net1 ENSMUSG00000021215.8 4091.52223 -1.09244822 0.272224367 -4.01304348 5.99E-05 0.004262883 12.4734502 11.32278968 8 Nhsl1 ENSMUSG00000039835.9 156.2164496 1.546493981 0.32698759 4.729518882 2.25E-06 0.000310923 6.988993569 8.235393268 8 Nos3 ENSMUSG00000028978.6 107.2361871 -1.839964 0.491715985 -3.741924318 0.000182617 0.009553568 7.664795038 6.186360618 8 Nov ENSMUSG00000037362.8 187.0978011 1.945446002 0.348544398 5.581630384 2.38E-08 9.13E-06 6.891375222 8.532425707 8 Npy1r ENSMUSG00000036437.5 286.1298197 1.969583948 0.402791733 4.889832105 1.01E-06 0.000158976 7.10418122 9.089959801 8 Nr1h3 ENSMUSG00000002108.4 1075.710635 -1.625250904 0.419688438 -3.872517696 0.000107717 0.00648417 10.59874113 8.868831352 8 Nrip1 ENSMUSG00000048490.7 2734.337373 -1.423325598 0.390966357 -3.640532161 0.000272075 0.012703119 11.89477559 10.36545482 8 Nrn1 ENSMUSG00000039114.9 2685.238766 -1.358630125 0.430476348 -3.156108651 0.001598893 0.046067247 11.75305576 10.30805656 8 Nsdhl ENSMUSG00000031349.4 1948.363912 -1.315955264 0.394369916 -3.3368551 0.000847321 0.028968757 11.38621671 9.987644732 8 Nsun7 ENSMUSG00000029206.7 86.98979606 -1.216749838 0.378087486 -3.218170086 0.001290113 0.039680389 7.530057106 6.64061344 8 Ntn3 ENSMUSG00000079662.1 360.2906308 -1.508609979 0.390656651 -3.861728639 0.000112588 0.006682305 9.179772744 7.754389857 8 Nup107 ENSMUSG00000052798.6 3623.888664 1.770178249 0.259356781 6.825263033 8.78E-12 1.54E-08 10.62783431 12.4974093 Page 77 of 79 Diabetes
8 Oas1a ENSMUSG00000052776.9 307.7649892 2.543316785 0.481191931 5.285451852 1.25E-07 3.65E-05 6.331823687 9.207209026 8 Oas1b ENSMUSG00000029605.8 223.1404185 1.683508371 0.445533423 3.778635411 0.00015769 0.008573763 6.934502262 8.719952748 8 Oas1c ENSMUSG00000001166.10 87.94038182 1.263651027 0.393385457 3.212246425 0.001317014 0.039944941 6.6044115 7.559896688 8 Oas1g ENSMUSG00000066861.7 208.4270518 2.56102602 0.484585098 5.284987161 1.26E-07 3.65E-05 6.067525701 8.706607459 8 Oas2 ENSMUSG00000032690.9 444.2200829 2.891670761 0.419328512 6.895955509 5.35E-12 1.25E-08 6.79836916 9.757191238 8 Oasl2 ENSMUSG00000029561.10 2496.266685 2.324109474 0.449921779 5.165585631 2.40E-07 5.77E-05 8.830718697 12.09603002 8 Obfc2a ENSMUSG00000026107.5 5123.237416 -1.539216833 0.393653411 -3.910081282 9.23E-05 0.005738479 12.81119687 11.12558909 8 Odf3l1 ENSMUSG00000045620.6 39.80548093 -1.644328826 0.505905731 -3.250267245 0.001152966 0.036805384 6.729008245 5.539288288 8 Ogn ENSMUSG00000021390.5 5326.671916 0.984882049 0.244682457 4.025143691 5.69E-05 0.004119025 11.7841443 12.82302362 8 Olr1 ENSMUSG00000030162.7 124.235721 -1.865099806 0.470720967 -3.962219524 7.43E-05 0.004945136 7.909040063 6.37144381 8 Oplah ENSMUSG00000022562.7 474.3496294 -1.196160895 0.357650665 -3.344495092 0.000824325 0.028355094 9.483161934 8.325220542 8 Orm1 ENSMUSG00000039196.2 1766.568499 -1.79435143 0.442600451 -4.054111163 5.03E-05 0.003838157 11.26199325 9.237772676 8 Ostn ENSMUSG00000052276.8 90.60632393 1.752034099 0.411826699 4.254299448 2.10E-05 0.001920962 6.358350614 7.697902257 8 Pank3 ENSMUSG00000018846.8 14101.64162 -1.564435995 0.427294236 -3.661261636 0.000250976 0.011949733 14.17431047 12.44622984 8 Paqr4 ENSMUSG00000023909.3 2449.284557 -1.552189604 0.418191036 -3.711675929 0.000205891 0.010225665 11.73801598 10.00763253 8 Parm1 ENSMUSG00000034981.9 2001.736534 -2.2374521 0.362565131 -6.171172876 6.78E-10 4.97E-07 11.67725088 9.2628262 8 Parp14 ENSMUSG00000034422.8 2043.438207 1.879768597 0.380648093 4.938337092 7.88E-07 0.000134145 9.498648643 11.70000794 8 Parp9 ENSMUSG00000022906.8 1623.743946 1.163308463 0.316007298 3.681270879 0.000232074 0.011208058 9.963208617 11.1684773 8 Pcdh9 ENSMUSG00000055421.2 117.6343213 1.467447363 0.425461847 3.449069226 0.000562522 0.021846351 6.663301299 7.89132384 8 Pcx ENSMUSG00000024892.8 28301.2162 -1.950988839 0.431027642 -4.526365943 6.00E-06 0.000683386 15.28937612 12.96669481 8 Pcyt2 ENSMUSG00000025137.9 1543.057281 -1.16405281 0.363511458 -3.202245168 0.001363609 0.041097879 11.06162124 9.842885116 8 Pde3b ENSMUSG00000030671.8 2142.785357 -1.633460751 0.459931371 -3.551531502 0.000382996 0.016260453 11.37795363 9.601145519 8 Pdgfb ENSMUSG00000000489.6 54.23238174 1.963811634 0.454232336 4.323363793 1.54E-05 0.001501412 5.908183408 7.232909811 8 Pdgfrl ENSMUSG00000031595.9 1329.909388 1.127191326 0.317794679 3.546916928 0.000389767 0.016423827 9.677161811 10.92362775 8 Pdzd2 ENSMUSG00000022197.8 1532.070784 -2.322960911 0.431255606 -5.386506007 7.18E-08 2.37E-05 11.17373066 8.594026856 8 Pdzk1 ENSMUSG00000038298.8 49.39419622 -1.920723042 0.505982675 -3.796025316 0.000147034 0.008179097 6.869973951 5.453578626 8 Peg10 ENSMUSG00000092035.1 3251.453218 -1.360685869 0.269461989 -5.049639367 4.43E-07 8.83E-05 12.23661009 10.79348001 8 Peli2 ENSMUSG00000021846.7 1914.445083 -1.021397452 0.246877455 -4.137264986 3.51E-05 0.002903936 11.38070283 10.32909714 8 Pemt ENSMUSG00000000301.9 208.8356235 -1.472140613 0.466695524 -3.154391967 0.001608329 0.046234782 8.365796206 7.058928499 8 Pex11a ENSMUSG00000030545.7 1300.759661 -1.715068501 0.421728479 -4.066759976 4.77E-05 0.003685779 10.86562642 9.026868067 8 Pex16 ENSMUSG00000027222.8 1178.800831 -1.274171765 0.403327447 -3.159149653 0.001582302 0.045796561 10.6584234 9.341023335 8 Pfkfb1 ENSMUSG00000025271.7 450.2497197 -1.538197721 0.470794866 -3.267235544 0.001086033 0.035117893 9.236519478 7.744109655 8 Pfkfb3 ENSMUSG00000026773.10 1806.438418 -1.834334194 0.474765788 -3.863661279 0.0001117 0.006676259 11.07204095 9.049208131 8 Phf11 ENSMUSG00000044703.5 113.5677938 2.204853511 0.38958737 5.659458391 1.52E-08 7.11E-06 6.344158476 7.984582948 8 Phkg1 ENSMUSG00000025537.6 212.0207987 -1.282638756 0.308293762 -4.160443429 3.18E-05 0.002703868 8.529371352 7.431390091 8 Pkia ENSMUSG00000027499.7 382.8060173 1.039348434 0.31661533 3.282685129 0.001028234 0.033849398 8.190047825 9.207782819 8 Pkp4 ENSMUSG00000026991.11 1016.769916 0.878088623 0.260812811 3.366738853 0.000760627 0.027047183 9.5646761 10.44906485 8 Pla2g16 ENSMUSG00000060675.7 4850.640734 -1.786867723 0.414896189 -4.306782687 1.66E-05 0.001568521 12.75206137 10.73910949 8 Plat ENSMUSG00000031538.5 1843.134585 1.124432364 0.291174401 3.861714348 0.000112594 0.006682305 10.15715315 11.37225937 8 Plcb2 ENSMUSG00000040061.11 80.40409402 -2.296494734 0.484402004 -4.740886117 2.13E-06 0.000296405 7.505063435 5.851930824 8 Plin1 ENSMUSG00000030546.7 10871.80765 -1.756239207 0.469968361 -3.736930723 0.00018628 0.009601691 13.69867374 11.55747834 8 Plin4 ENSMUSG00000002831.7 18851.64147 -1.916926693 0.41534357 -4.61527957 3.93E-06 0.000479472 14.71387534 12.52526582 8 Plscr2 ENSMUSG00000032372.7 89.37776474 1.483604287 0.376854997 3.936804071 8.26E-05 0.005291955 6.534049947 7.622173812 8 Pmvk ENSMUSG00000027952.8 876.5763666 -1.113226436 0.345727298 -3.219955269 0.001282106 0.039651187 10.31211939 9.129825407 8 Pnp ENSMUSG00000021871.10 2394.516593 1.01719735 0.296321627 3.432747581 0.000597498 0.022940388 10.58666734 11.70805913 8 Pnp2 ENSMUSG00000068417.7 1008.08963 1.051143765 0.303640495 3.461803616 0.000536569 0.02098344 9.389279375 10.5088444 8 Pnpla2 ENSMUSG00000025509.8 14090.01178 -1.645881531 0.44684471 -3.683341199 0.000230197 0.011189998 14.20471658 12.18867018 8 Pnpla8 ENSMUSG00000036257.8 2850.892543 -1.144328473 0.340609377 -3.359650527 0.000780411 0.027576167 11.93608738 10.72776606 8 Podn ENSMUSG00000028600.8 298.0133242 -1.24117763 0.311678843 -3.982232533 6.83E-05 0.004716011 8.931750833 7.806238421 8 Poln ENSMUSG00000045102.7 374.61023 -2.055557891 0.454768953 -4.520004887 6.18E-06 0.000685829 9.226420642 7.170902047 8 Pparg ENSMUSG00000000440.6 4295.092058 -1.808948661 0.434700059 -4.161372017 3.16E-05 0.002703868 12.52302679 10.46899398 8 Ppargc1a ENSMUSG00000029167.7 441.7970603 -1.181395927 0.292793629 -4.03490995 5.46E-05 0.003985605 9.431197886 8.294072065 8 Ppargc1b ENSMUSG00000033871.8 245.5210811 -1.511608251 0.470206531 -3.214775108 0.001305468 0.039934039 8.535856398 7.161462141 8 Ppef1 ENSMUSG00000062168.6 523.6224166 2.597634518 0.334999328 7.754148441 8.89E-15 3.75E-11 7.462554459 9.911115369 8 Ppip5k1 ENSMUSG00000033526.9 1531.975155 -1.082860229 0.33084112 -3.273052115 0.001063929 0.034685718 11.05238064 9.93168144 8 Ppp1r12b ENSMUSG00000073557.4 1667.034795 0.898836587 0.248835579 3.6121707 0.000303645 0.013757874 10.22073833 11.14565816 8 Prelp ENSMUSG00000041577.5 5033.908076 -0.955995683 0.291472069 -3.279887804 0.001038484 0.034053782 12.73121759 11.6881418 8 Prkd1 ENSMUSG00000002688.7 71.43963011 2.981922126 0.437286689 6.819146805 9.16E-12 1.54E-08 5.707210362 7.567704304 8 Prlr ENSMUSG00000005268.13 460.6132948 -1.758944065 0.470488727 -3.738546672 0.000185087 0.009601691 9.325741674 7.557423041 8 Prps2 ENSMUSG00000025742.5 1368.964092 0.861572148 0.267254967 3.223783485 0.00126509 0.039196864 9.96484732 10.85901038 8 Prtn3 ENSMUSG00000057729.6 16.20141792 -1.719755559 0.505888756 -3.399473774 0.000675157 0.024901014 6.313272993 5.396520578 8 Psmb8 ENSMUSG00000024338.8 199.4673263 1.371371162 0.322125502 4.257257353 2.07E-05 0.001906089 7.310348054 8.479728877 8 Ptgs2 ENSMUSG00000032487.7 74.2998322 1.37843373 0.415663381 3.316226044 0.00091242 0.030712672 6.399842045 7.430465772 8 Ptpn4 ENSMUSG00000026384.7 755.2831005 -1.225298534 0.325315726 -3.76649033 0.000165558 0.008858693 10.12941545 8.905212022 8 Ptprj ENSMUSG00000025314.9 239.527712 1.377616622 0.409104651 3.36739418 0.000758821 0.027047183 7.314374727 8.739634849 8 Ptprq ENSMUSG00000035916.5 149.0885972 3.407590851 0.395907219 8.607043985 7.50E-18 1.26E-13 5.938108549 8.418418033 8 Pxmp4 ENSMUSG00000000876.5 2432.343527 -1.202338914 0.366709189 -3.278725894 0.001042769 0.034127896 11.70828494 10.4263106 8 Ralgapa2 ENSMUSG00000037110.12 3380.478258 -1.574781485 0.35759821 -4.403773402 1.06E-05 0.001080183 12.28650153 10.58018225 8 Ranbp3l ENSMUSG00000048424.8 113.809079 -1.91596953 0.468038456 -4.09361561 4.25E-05 0.003329436 7.983331535 6.23375869 8 Rarres2 ENSMUSG00000009281.4 2496.957772 -1.900104709 0.396534893 -4.791771775 1.65E-06 0.000240205 11.87246699 9.781168395 8 Rassf6 ENSMUSG00000029370.7 71.0119549 -1.77930771 0.505104111 -3.522655373 0.000427247 0.017824852 7.066253871 5.602636035 8 Rbm47 ENSMUSG00000070780.5 184.2555804 -1.809006966 0.49303891 -3.669095743 0.00024341 0.01168853 8.151911089 6.541429779 8 Reep6 ENSMUSG00000035504.10 580.1901383 -1.659251471 0.484283732 -3.426197003 0.000612096 0.023288674 9.551436148 7.743487275 8 Retsat ENSMUSG00000056666.6 3670.368021 -1.4202652 0.397189018 -3.57579172 0.00034917 0.015101677 12.31417961 10.74744081 8 Rin1 ENSMUSG00000024883.6 553.3460269 1.222305335 0.357624087 3.417849579 0.00063118 0.023799856 8.433411466 9.759145765 8 Rnd1 ENSMUSG00000054855.7 92.3359677 1.358213363 0.374575176 3.626010083 0.000287834 0.013255312 6.617371631 7.629237785 8 Rnf125 ENSMUSG00000033107.4 274.8560549 -1.531168976 0.474132036 -3.229414722 0.001240439 0.0386462 8.716359339 7.181681271 8 Rnf213 ENSMUSG00000070327.6 15987.89813 1.669298427 0.388552443 4.296198509 1.74E-05 0.001626994 12.47399843 14.63707736 8 Robo1 ENSMUSG00000022883.9 93.08491443 2.782505518 0.396457724 7.018416716 2.24E-12 6.77E-09 5.974632892 7.839251187 8 Robo2 ENSMUSG00000052516.11 170.4773368 2.542855884 0.428302598 5.93705454 2.90E-09 1.85E-06 6.332369588 8.454476597 8 Rpusd3 ENSMUSG00000051169.8 397.8238754 -1.124322156 0.319754557 -3.516203697 0.000437765 0.018084629 9.273932943 8.184583953 8 Rsad2 ENSMUSG00000020641.8 214.4121745 2.825067011 0.479822709 5.887730943 3.92E-09 2.28E-06 5.974425041 8.770325412 8 Rspo3 ENSMUSG00000019880.9 181.0838432 1.633721399 0.467738621 3.492808431 0.000477969 0.019365798 6.682327867 8.482108722 8 Rtn4rl1 ENSMUSG00000045287.6 37.76793256 -1.80295357 0.448939443 -4.016028435 5.92E-05 0.004227114 6.895353825 5.844537814 8 Rtp4 ENSMUSG00000033355.5 688.7713298 2.078015257 0.369158885 5.629053889 1.81E-08 7.69E-06 8.045402169 10.21290183 8 S100a1 ENSMUSG00000044080.9 990.6506938 -2.238991616 0.43714945 -5.121799002 3.03E-07 6.62E-05 10.54744447 8.127867629 Diabetes Page 78 of 79
8 S100a8 ENSMUSG00000056054.8 50.60374164 -2.152525919 0.472381387 -4.556754302 5.20E-06 0.000612321 7.175215303 5.746388272 8 S100b ENSMUSG00000033208.7 131.0913889 -1.272866637 0.367065788 -3.467679854 0.000524972 0.020577694 7.987604838 6.928391976 8 Saa4 ENSMUSG00000040017.7 21.50595726 -1.836035853 0.494826427 -3.710464426 0.000206879 0.010225665 6.511934735 5.513100196 8 Samd9l ENSMUSG00000047735.10 3433.596994 1.293106383 0.360071971 3.591244217 0.000329103 0.01455914 10.77112564 12.30035053 8 Sc4mol ENSMUSG00000031604.4 4148.909485 -1.192692792 0.349731972 -3.410305282 0.000648902 0.024197441 12.48755279 11.19128126 8 Scarb1 ENSMUSG00000037936.9 4050.323084 -1.784725808 0.433230316 -4.119577376 3.80E-05 0.003061061 12.44318441 10.41748945 8 Scg2 ENSMUSG00000050711.5 9.26270129 1.584157481 0.500037298 3.168078635 0.0015345 0.044747403 5.123822884 6.055086617 8 Schip1 ENSMUSG00000027777.7 137.6633815 1.232386527 0.350937016 3.511702877 0.000445245 0.018348686 7.020984819 8.020468523 8 Scp2 ENSMUSG00000028603.9 9951.382139 -1.616148731 0.418146636 -3.865028657 0.000111076 0.006662593 13.71619882 11.92676744 8 Scp2-ps2 ENSMUSG00000058492.4 1545.983775 -1.651409672 0.424096607 -3.893946907 9.86E-05 0.006089177 11.07569791 9.308513269 8 Sema4g ENSMUSG00000025207.8 232.8996334 -1.216635958 0.355227559 -3.424948109 0.000614917 0.023343296 8.606729848 7.529572497 8 Sema5a ENSMUSG00000022231.8 1406.34249 1.2107456 0.304737215 3.973080878 7.09E-05 0.004821954 9.737683534 10.99441772 8 Sema6a ENSMUSG00000019647.9 179.2584118 2.236298399 0.430357841 5.196369596 2.03E-07 5.11E-05 6.494064627 8.53820617 8 Sema6d ENSMUSG00000027200.11 2911.528116 -1.335337359 0.298451579 -4.474217767 7.67E-06 0.000818124 12.0528733 10.64565395 8 Sh2b2 ENSMUSG00000005057.9 1673.688366 -1.730509672 0.461492182 -3.749813626 0.000176966 0.009379757 11.13554492 9.087065268 8 Sh2d3c ENSMUSG00000059013.6 417.964501 -1.862281872 0.360276554 -5.169034324 2.35E-07 5.75E-05 9.495427801 7.694216692 8 Sh3tc1 ENSMUSG00000036553.9 324.0254035 -1.45955395 0.435529399 -3.351217972 0.000804569 0.027960862 8.958806809 7.588056622 8 Shmt2 ENSMUSG00000025403.3 1633.560659 0.8192839 0.250558066 3.269836454 0.001076097 0.034880022 10.24663366 11.08683444 8 Siglec1 ENSMUSG00000027322.4 1069.731646 -2.046529322 0.452356083 -4.524155635 6.06E-06 0.000685829 10.56215596 8.320021295 8 Slc13a4 ENSMUSG00000029843.4 631.4667371 -2.511003654 0.48004371 -5.230781283 1.69E-07 4.45E-05 9.742169591 7.075529901 8 Slc1a3 ENSMUSG00000005360.8 4673.774803 -2.211176384 0.385735531 -5.732363768 9.90E-09 4.77E-06 12.8419441 10.35589218 8 Slc1a4 ENSMUSG00000020142.6 2311.481751 1.035914459 0.277159691 3.737608647 0.000185779 0.009601691 10.54924354 11.65820735 8 Slc25a10 ENSMUSG00000025792.3 6121.662649 -1.698710884 0.427856044 -3.970286052 7.18E-05 0.004837326 13.04069802 11.09344838 8 Slc38a1 ENSMUSG00000023169.8 136.9536695 2.094113298 0.386429028 5.419140765 5.99E-08 2.10E-05 6.508376417 8.20097874 8 Slc43a1 ENSMUSG00000027075.10 453.1340003 -1.935906911 0.319406519 -6.060949913 1.35E-09 9.50E-07 9.632470086 7.792751728 8 Slc46a3 ENSMUSG00000029650.4 311.1492589 -1.132966019 0.349381463 -3.242776566 0.00118371 0.037389495 8.938082443 7.89262397 8 Slc5a6 ENSMUSG00000006641.6 1809.402009 -1.475718112 0.394282204 -3.742796653 0.000181983 0.009553568 11.35646323 9.72079038 8 Slc6a9 ENSMUSG00000028542.10 466.0498569 1.402886164 0.383753059 3.655700273 0.000256481 0.012177423 8.040062857 9.597736464 8 Slc7a1 ENSMUSG00000041313.8 2068.679699 1.262000018 0.282984219 4.459612707 8.21E-06 0.000870395 10.22842171 11.57015321 8 Slc7a5 ENSMUSG00000040010.8 4586.477751 1.39567132 0.308778957 4.519969016 6.18E-06 0.000685829 11.18965342 12.74460571 8 Slfn10-ps ENSMUSG00000072621.5 104.0687295 1.516273624 0.45409069 3.339142722 0.000840374 0.028789633 6.440105572 7.828168276 8 Slfn2 ENSMUSG00000072620.3 154.1837779 1.742405511 0.48562954 3.58793147 0.000333312 0.014679241 6.389364532 8.289759454 8 Slfn8 ENSMUSG00000035208.9 310.7291304 1.674338509 0.471971304 3.547543026 0.000388842 0.016423827 7.043750681 9.159747795 8 Snhg12 ENSMUSG00000086290.1 546.568003 1.065742626 0.304959586 3.494701179 0.000474593 0.019321887 8.61143244 9.676362958 8 Sorbs1 ENSMUSG00000025006.8 2304.274868 -1.604876656 0.442256523 -3.628836598 0.000284701 0.013183081 11.58629539 9.789064011 8 Sorbs2 ENSMUSG00000031626.9 328.9234196 2.11073147 0.301171699 7.008399114 2.41E-12 6.77E-09 7.374109716 9.249556675 8 Sorbs3 ENSMUSG00000022091.5 1233.22801 0.990754389 0.307758064 3.219263777 0.001285202 0.039674139 9.690801053 10.76974225 8 Sort1 ENSMUSG00000068747.7 7006.965706 -1.795022957 0.417669879 -4.297707465 1.73E-05 0.001624989 13.29751963 11.20897885 8 Sox5 ENSMUSG00000041540.9 148.6300875 -1.318301724 0.38011391 -3.468175437 0.000524005 0.020577694 8.105669754 7.020297332 8 Sp100 ENSMUSG00000026222.9 711.3799295 1.91868645 0.420353485 4.564459484 5.01E-06 0.000594415 7.971674989 10.28993959 8 Sp110 ENSMUSG00000070034.7 174.6105395 1.618167726 0.421284862 3.841029837 0.000122519 0.007120902 6.857337844 8.41982712 8 Sp140 ENSMUSG00000070031.5 628.4025605 0.983489059 0.273200274 3.599883131 0.00031836 0.01423332 8.863553325 9.835248831 8 Sparcl1 ENSMUSG00000029309.3 7178.308033 -1.211941795 0.247616548 -4.894429726 9.86E-07 0.000156769 13.32108274 12.04322743 8 Spire2 ENSMUSG00000010154.6 293.4517727 1.026327425 0.305761989 3.356622019 0.000789009 0.02759076 7.923627043 8.850987419 8 Spna1 ENSMUSG00000026532.7 12.08989548 1.678581123 0.506664697 3.313001936 0.000923003 0.030990483 5.30223805 6.176842151 8 Spry4 ENSMUSG00000024427.6 1218.019333 -1.916003773 0.411498049 -4.656167333 3.22E-06 0.000405212 10.83923253 8.792123585 8 St3gal4 ENSMUSG00000032038.6 1429.062707 -0.886408197 0.273114004 -3.245561132 0.001172194 0.037207776 10.91843973 10.01128832 8 St3gal6 ENSMUSG00000022747.10 177.56709 -2.620986092 0.420240757 -6.236867912 4.46E-10 3.42E-07 8.489059998 6.356237893 8 Stat2 ENSMUSG00000040033.8 3107.543804 1.365911693 0.366264139 3.729307746 0.000192007 0.009864585 10.57495551 12.15953321 8 Stbd1 ENSMUSG00000047963.5 157.7704728 1.440642636 0.333081088 4.325200943 1.52E-05 0.001501412 7.046548949 8.224257159 8 Steap1 ENSMUSG00000015652.3 233.9112899 1.896416668 0.381300113 4.97355391 6.57E-07 0.00011663 7.038134188 8.812046156 8 Stx1b ENSMUSG00000030806.5 116.3381819 -1.509147913 0.433414333 -3.481998166 0.000497687 0.019878 7.857452786 6.631936273 8 Sucnr1 ENSMUSG00000027762.5 102.8414105 -1.791358541 0.505034739 -3.547000638 0.000389644 0.016423827 7.663448834 5.907888767 8 Sult1a1 ENSMUSG00000030711.8 596.0387668 -1.516112828 0.451670158 -3.35668142 0.000788839 0.02759076 9.722600692 8.121570372 8 Syn2 ENSMUSG00000009394.6 514.2776149 -2.283729123 0.474614203 -4.811758912 1.50E-06 0.000221196 9.580289518 7.114088948 8 Syt13 ENSMUSG00000027220.2 184.8101144 1.420118419 0.393494997 3.608987225 0.000307395 0.013853311 7.103671682 8.41411029 8 Taldo1 ENSMUSG00000025503.4 4125.383873 -1.476755498 0.433314594 -3.408044685 0.000654302 0.024344937 12.38274159 10.77406393 8 Tap1 ENSMUSG00000037321.9 1684.679766 1.204187963 0.342227526 3.518676525 0.000433705 0.018005174 9.936358688 11.23622782 8 Tcf7l2 ENSMUSG00000024985.11 977.8382895 -1.502813092 0.267406846 -5.619949949 1.91E-08 7.69E-06 10.58579181 9.075709318 8 Tgfb2 ENSMUSG00000039239.8 1134.428677 -1.284157497 0.320844765 -4.002426205 6.27E-05 0.004384834 10.71811207 9.376788193 8 Tgtp1 ENSMUSG00000078922.3 780.6814295 2.574869815 0.44907248 5.733751072 9.82E-09 4.77E-06 7.326957931 10.50055105 8 Tgtp2 ENSMUSG00000078921.3 884.383292 2.5520863 0.453336742 5.629559798 1.81E-08 7.69E-06 7.423642458 10.67533138 8 Thbs1 ENSMUSG00000040152.8 13725.02765 1.707382652 0.287762176 5.933311579 2.97E-09 1.85E-06 12.51132213 14.40013474 8 Timp4 ENSMUSG00000030317.6 366.8025473 -3.143826515 0.378232906 -8.311879959 9.42E-17 7.94E-13 9.478134029 6.678160001 8 Tlr3 ENSMUSG00000031639.5 919.9735805 1.225808207 0.297909084 4.1147057 3.88E-05 0.003111543 9.171068773 10.41930769 8 Tlr8 ENSMUSG00000040522.4 179.5584343 -2.093735113 0.428455959 -4.886698545 1.03E-06 0.00016003 8.422433061 6.642454718 8 Tm7sf2 ENSMUSG00000024799.7 671.1242147 -1.479578123 0.442371178 -3.344653077 0.000823856 0.028355094 9.868673998 8.352225172 8 Tmcc3 ENSMUSG00000020023.10 1336.03068 -1.435327046 0.442651233 -3.242568728 0.001184574 0.037389495 10.81862289 9.210639986 8 Tmed5 ENSMUSG00000063406.5 2905.326236 -1.027852373 0.323205165 -3.180185477 0.001471808 0.043293763 11.93726453 10.85987616 8 Tmem120a ENSMUSG00000039886.2 7227.431034 -1.777166101 0.473358561 -3.754376173 0.000173774 0.009266338 13.07981242 10.93959108 8 Tmem120b ENSMUSG00000054434.8 882.613678 -1.655222093 0.471723782 -3.508879888 0.000449998 0.018499311 10.15383826 8.344481542 8 Tmem179 ENSMUSG00000054013.5 419.3225975 -1.639115843 0.483338998 -3.391234415 0.000695786 0.025384127 9.171488674 7.431139093 8 Tmem182 ENSMUSG00000079588.1 171.730078 -2.02868876 0.474751422 -4.273159945 1.93E-05 0.001784797 8.290537926 6.43858955 8 Tmem74 ENSMUSG00000054409.4 19.54683029 1.784829162 0.496470111 3.5950385 0.000324344 0.014424305 5.501234329 6.439269273 8 Tor3a ENSMUSG00000060519.5 2373.249147 1.196391705 0.349438016 3.423759435 0.000617613 0.023392948 10.406365 11.70350409 8 Tpm1 ENSMUSG00000032366.9 10786.0048 1.071393377 0.278216339 3.850936226 0.000117667 0.006934544 12.70933345 13.85324208 8 Trem2 ENSMUSG00000023992.8 98.38615899 -1.578204381 0.425008357 -3.71334905 0.000204534 0.010199493 7.6975646 6.505132536 8 Trib3 ENSMUSG00000032715.8 2110.42328 1.064184018 0.270932412 3.927857909 8.57E-05 0.005426796 10.40942245 11.53864114 8 Trim30a ENSMUSG00000030921.9 2023.571785 1.453053935 0.398557146 3.645785677 0.000266576 0.01251571 9.762246715 11.63031117 8 Trim30d ENSMUSG00000057596.7 917.8199111 1.594096421 0.420945774 3.786940076 0.000152514 0.008428266 8.526022558 10.58278687 8 Trim67 ENSMUSG00000036913.8 49.82613354 -2.25814457 0.497127226 -4.542387642 5.56E-06 0.000646542 7.084096976 5.584570629 8 Trpv1 ENSMUSG00000005952.9 37.97233032 -1.674168565 0.498610983 -3.357664839 0.000786039 0.02759076 6.805442781 5.737355368 8 Tspan12 ENSMUSG00000029669.7 1857.831773 -1.954664153 0.384003398 -5.090226192 3.58E-07 7.35E-05 11.48741349 9.37482413 8 Tspan7 ENSMUSG00000058254.6 189.6629417 1.705488793 0.413353445 4.125981809 3.69E-05 0.003017564 6.902612738 8.518003635 8 Ubd ENSMUSG00000035186.6 511.1564473 -1.736072658 0.429738548 -4.039834611 5.35E-05 0.003974414 9.65119778 7.832601257 8 Ube2l6 ENSMUSG00000027078.7 928.7536541 1.214261372 0.346996024 3.499352411 0.00046639 0.019126518 9.100403597 10.45316603 Page 79 of 79 Diabetes
8 Usp18 ENSMUSG00000030107.9 886.8833397 2.157693889 0.413904534 5.213023087 1.86E-07 4.74E-05 8.16544232 10.46568333 8 Vnn3 ENSMUSG00000020010.7 110.0594356 -1.72564173 0.481941959 -3.580600729 0.000342805 0.014891703 7.7154654 6.333920931 8 Wisp1 ENSMUSG00000005124.3 2749.075019 0.927947068 0.263861327 3.5167983 0.000436786 0.018084629 10.87824408 11.86451531 8 Wisp2 ENSMUSG00000027656.7 825.5275369 1.034846305 0.301842101 3.428435937 0.00060707 0.023171562 9.143928623 10.22938376 8 Xaf1 ENSMUSG00000040483.9 806.3985249 1.882245511 0.401999016 4.682214226 2.84E-06 0.0003708 8.228254709 10.44709713 8 Yeats4 ENSMUSG00000020171.6 2326.005773 1.398865962 0.262805989 5.322808547 1.02E-07 3.25E-05 10.30951088 11.7709861 8 Zbp1 ENSMUSG00000027514.8 365.3048719 2.919600183 0.367100775 7.953129993 1.82E-15 1.02E-11 6.847735425 9.458923542 8 Zbtb16 ENSMUSG00000066687.4 356.2823525 -1.107783613 0.30884014 -3.586915909 0.000334612 0.014679241 9.127750244 8.082064637 8 Zfp423 ENSMUSG00000045333.9 904.4732779 -0.999925658 0.297853261 -3.357108316 0.000787623 0.02759076 10.3174321 9.313228509 8 Zfp467 ENSMUSG00000068551.6 667.0283325 -1.10110577 0.322373324 -3.415623095 0.000636363 0.023941722 9.928761979 8.837208618 8 Zfp518a ENSMUSG00000049164.5 66.57131286 -1.458438268 0.441464388 -3.303637411 0.000954392 0.031854009 7.336690123 6.248625652