Serious Fungal Infections in Canada
Eur J Clin Microbiol Infect Dis DOI 10.1007/s10096-017-2922-y ORIGINAL ARTICLE Serious fungal infections in Canada S. F. Dufresne1 & D. C. Cole 2 & D. W. Denning 3 & D. C. Sheppard4 Received: 21 December 2016 /Accepted: 21 December 2016 # Springer-Verlag Berlin Heidelberg 2017 Abstract There are currently no nationwide epidemiological of cryptococcosis. These estimates warrant validation through data on fungal infections in Canada. We estimated the burden more formal epidemiological studies in Canada. of serious fungal diseases using literature review and model- ing, as per a methodology previously described by the LIFE program (http://www.LIFE-worldwide.org). Among the Introduction population of Canada (35.5 million in 2014), it was estimated that approximately 1.8% are affected by a serious Canada is a high-income country with a gross domestic fungal infection. Recurrent vulvovaginal candidiasis, severe product of 1551 billion dollars (USD) in 2015 (GDP per asthma with fungal sensitization, and allergic capita, 43,249). Several studies have examined the epide- bronchopulmonary aspergillosis are the most frequent miology of fungal infections in Canada, but most were infections, with population prevalences of 498,688 local (single-centered, regional, or provincial) and focused (1403/100,000), 73,344 (206/100,000), and 61,854 (174/ on individual infections in specific populations. A single 100,000) cases, respectively. Over 3000 invasive fungal study reported on the burden of invasive fungal infections infections are estimated to occur annually, with incidences of at the national level; however, these data are over 20 years 2068 cases (5.8/100,000) of invasive candidiasis, 566 cases old [1] and relied largely on clinical microbiology labora- (1.6/100,000) of invasive aspergillosis, 252 cases (0.71/ tory records review.
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