Standardizednomenclaturefor Inbred Strainsof Mice
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[CANCER RESEARCH 45, 945-977, March 1985] StandardizedNomenclaturefor InbredStrainsof Mice: EighthListing1 Joan Staats The Jackson Laboratory, Bar Harbor, Maine 04609 For the International Committee on Standardized Genetic Nomenclature for Mice ABSTRACT to be extinct or because they were not reported. Appendix 2 is a list of standard abbreviations for the names of persons or This paper presents a list of inbred strains of mice with their institutions maintaining inbred strains. The principal use of the origins and characteristics, and a list of standard subline desig symbols is in designating sublines. For example, strain AU/Ss nations. upon transfer from Silvers to The Jackson Laboratory becomes AU/SsJ or AU/J. INTRODUCTION The Committee stresses the importance of using full strain or substrain designations in publications, and also of spelling out Previous listings of Standardized Nomenclature for Inbred the source of the animals. The brief symbol C57, for example, Strains of Mice appeared in Cancer Research in 1952, 1960, could stand for seven or eight different strains. The many differ 1964,1968,1972,1976, and 1980 (5). Between issues, additions ences among substrains emphasize the importance of using full and deletions to strain holdings appear in Mouse News Letter (4) designations. For example, CBA/J carries the gene for retinal and Inbred Strains of Mice (3). degeneration whereas CBA/Ca has the normal alÃele;the two Most fostered and otherwise manipulated lines, named genes differ in radiosensitivity, they are not histocompatible, and they on inbred backgrounds, and congenie histocompatibility strains vary in at least five polymorphic loci. We also stress the impor have been omitted, to keep the list to a manageable size. Lists tance of identifying the sex of the parents when listing hybrids. of congenie and segregating inbred strains and recombinant It is customary to list the female first. Thus, C57BL/6J 9 x DBA/ inbred strains can be found in two new publications (1,2). Since 2J a is B6D2F,, and DBA/2J 9 x C57BL/6J a is D2B6F,. comprehensive revised rules for nomenclature of strains, genes, and chromosome anomalies are presented in both these books, REFERENCES they are not included here. Appendix 1 is the list of inbred strains and some clearly defined 1. Foster, H. L, Small, J. D., and Fox, J. G. (eds ) The Mouse in Biomédical Research, Vol. 1. New York: Academic Press, Inc., 1981. substrains. It contains 233 entries, compared with 299 in the 2. Green, M. C. (ed.). Genetic Variants and Strains of the Laboratory Mouse. seventh listing and 124 in the first. Several strains have been Stuttgart: Gustav Fischer Verlag, 1981. dropped since the seventh listing, either because they are known 3. Inbred Strains of Mice: an informal biennial document listing laboratories maintaining inbred strains of mice; the companion document to Mouse News Letter. ISM No. 13 appeared in July 1983. 4. Mouse News Letter: an informal semiannual document carrying information on 1 Preparation of this paper was supported in part by Grant DEB 79-26708 from mutant genes, research stocks of mice, and research news. MNL is currently the National Science Foundation. Address requests for reprints to: Library, The edited by Dr. J. Peters; No. 71 appeared in July 1984. Jackson Laboratory. Bar Harbor, ME 04609. 5. Staats, J. Standardized nomenclature for inbred strains of mice: seventh listing. Received October 30,1984; accepted November 8,1984. Cancer Res., 40: 2083-2128,1980. APPENDIX BLM-2 Green, E. L. (ed.) Biology of the Laboratory List of inbred strains of mice and their clearly defined sub- Mouse, Ed. 2. New York: McGraw-Hill, strains. 1966. Abbreviations Charac characteristics. In some cases journal ref Inbr = number of generations of brother x sister erences are given. Letters in parentheses inbreeding. The substrain on which the fig indicate specific contributions to Inbred ure is based is indicated in parentheses. If Strains of Mice. The key to the letters will a line has been produced by appropriate be found in Appendix 2. In a few cases crosses to an inbred strain, the number of information has been obtained by corre generations is preceded by N. spondence or personal communication. Genet = genetic constitution, mainly mutant coat and eye colors. Maintained by persons or laboratories maintaining each strain, insofar as information is available, Origin origin. In some cases references are given. are indicated by substrain symbols. A table in Chap. 1 of BLM-2 gives more extensive information. b x s brother x sister inbreeding. CANCER RESEARCH VOL. 45 MARCH 1985 945 Downloaded from cancerres.aacrjournals.org on September 29, 2021. © 1985 American Association for Cancer Research. STANDARDIZED NOMENCLATURE FOR INBRED STRAINS OF MICE SNISM-7 Staats, J. Standardized nomenclature for than other sublines (E. S. Russell et al., inbred strains of mice: seventh listing. Can Proc. Soc. Exp. Biol. Med., 78: 761,1951) cer Res., 40: 2083-2128,1980. hematocrit 48%, systolic blood pressure 81 mm Hg (G. Schlager and R. S. Weibust, J. SPF specific-pathogen-free. Hered., 67: 295, 1976); cleft lip with or without cleft palate occurs sporadically (H. A/He Inbr: 195. Genet: abc. Origin: Strong, Kalter, Teratology, 20:213,1979); cleft pal 1921, from cross of Cold Spring Harbor ate is easily induced with a variety of albino and Bagg albino. Majority of sublines agents; very sensitive to X-irradiation (BLM- trace to a stock that Bittner obtained from 2); some heart disease in old breeders Strong in 1927. Charac: mammary tumor (BLM-2); moderately susceptible to audi- incidence varies with colony and breeding ogenic seizures over a long period up to status, from 0 to 80% (SNISM-7); some 245 days (E. Vicari, J. Psycho!., 43: 111, reticular tissue neoplasms; few skeletal var 1957); low alcohol preference (C. L. Good- iants (Gr); 40% of ?9 have positive LE cells rick, J. Stud. Alcohol, 39:19,1978); lowest or antinuclear antibodies (Umc); 84% neo- activity level of liver arylsulfatase C of 24 natally thymectomized develop runting syn Jax strains tested [K. Nelson and W. D. drome; high incidence of hyperplastic alveo Daniel, Experientia (Basel), 35: 309,1979]; lar nodules correlated with pregnancy (Ki); protein kinase C activity one-half that found cleft lip with or without deft palate occurs in 7 other strains (A. M. Malkinson et al., sporadically, cleft palate is easily induced Biochem. Biophys. Res. Commun., 722: with a variety of agents (H. Kalter, Teratol 492, 1984); resistant to Salmonella typhi- ogy, 20: 213, 1979); highly susceptible to murium C5 (V. Hormaeche, Immunology, measles virus (B. Rager-Zisman, Fed. 37: 311, 1979); intermediate susceptibility Proc., 35: 391, 1976); susceptible to Plas- to rabies virus (D. L. Lodmell, Fed. Proc., modium chabaudi (M. M. Stevenson ef al., 41:566,1982); susceptible to Ustoria mon- Infect. Immun., 3d: 80, 1982); resistant to ocytogenes (E. Skamene and P. A. L. Kong- Leishmania infection (D. J. Bradley, Clin. shaven, J. Reticuloendothel. Soc. 24 Exp. Immunol., 30:130, 1977). Maintained (Suppl.): 32a, 1978); resistant to Bacillus by: Crc, Cv, Dv, Fre, Icrf, Imr, Ki, Man, Ok, Calmette-Guerin (A. Forget et al., Fed. Ola, Ph, Ros, Ss, Sy, Tru, Tu, Y, Zgr. Proc., 41: 730,1982); most susceptible to Pseudomonas aeruginosa of 16 strains A/He Inbr (N): 215. Strong to Heston 1938, He to tested (J. E. Pennington and R. M. Williams, J 1948. Charac: low incidence of mammary J. Infect. Dis., Õ39:396,1979); sensitive to and lung tumors (SNISM-7); high incidence Cryptococcus neoformans due to the He" of renal disease in older animals, some cleft alÃele(J. C. Rhodes er a/., Infect. Immun., lip observed in young (J); cleft palate is 29:494,1980); for other susceptibilities see easily induced with a variety of agents; lung N. N. Nesbitt and E. Skamene. J. Leuk. tissue very susceptible to methylcholan- Biol., 36: 357, 1984. resistant to induction threne (J); most susceptible to ectromelia of amyloid (M. A. Scheinberg and E. S. virus of 8 strains tested (S. M. Ermolaeva Cathcart, Immunology, 37: 443, 1976). et al., Sov. Genet. (Eng. TransÃ.Genetika), Maintained by: Ao, Cr, Gh, Han, Ibg, J, Odn, 8: 681,1972); relatively susceptible to Op- Ola, Ori, Pt, Scr, Sg, Sx, Ucsd, Univ. Hel isthorchis felineus (A. G. Zelentsov, Med. sinki (O. Mäkelä),Yok Parazitol. Parazitamye Bolezni, 43: 95, 1974); susceptible to rabies virus infection AB/Jena Inbr (Jena): 70. Genet: AB DC Hbb". Origin: (D. L. Lodmell, Fed. Proc., 41: 566, 1982); from Agnes Bluhm to P. Hertwig in 1934, hematocrit 48%, systolic blood pressure 82 to J. Fortner in 1945, to H. Röhrerin 1949, mm Hg (G. Schlager and R. S. Weibust, J. to Jena in 1952; 1945-1959 random bred, Hered., 67: 295, 1976); serum «t-antitryp- new start of b x s in Jena in 1959 (Z. sin lowest of 34 strains tested (S. K. Chan, Versuchstierk Nd., 11: 241,1969). Charac: Arch. Environ. Health, 27:271,1973). Main av. litter size at birth 7.3 ±0.15 (S.D.), av. tained by: Cr, Cum, Gh, Hok, Han, 1er, J, litter size at weaning 6.5 ±0.10; sex ratio Kun, Mob, N, Novosibirsk, Rl, Ros, Sf, Sv. 49.2% do at weaning; body weight at wean ing (21 days) 10.2 ±0.28 g ?$, 10.9 ±0.30 A/J Inbr (J): 196. Origin: Strong to Cloudman g <5(î;meanlife span in Jena 18.1 mo $$; 1928; survivors of Bar Harbor fire to Jax fetal retentions and accompanying purulent 1947 at F73. Charac: mammary tumors panmetritis in a small number of breeding moderate (J); renal disease in older animals 9$; in animals older than 1 year more than (Umc); lower percentage of granulocytes 80% amyloidosis mostly affecting, in de- CANCER RESEARCH VOL.