BC INHERITED St. Paul’s Hospital (Vancouver) Royal Jubilee Hospital (Victoria) Northern Outreach Clinic (Hazelton) ARRHYTHMIA Ph: 604-682-2344 Ext. 66766 Ph: 250-727-4461 Ph: 250-727-4461 PROGRAM
List of Drugs to be Avoided by Patients with Congenital Long QT Syndrome (LQTS)* updated April 2015 *This list is not comprehensive but is meant to be a practical list for those clinicians managing patients with LQTS in Canada. Patients with LQTS should discuss ALL new medications (prescription and over the counter) with a health care provider. A complete up to date list is available at www.qtdrugs.org Drugs with ABSOLUTE Drugs with RELATIVE/THEORETICAL CONTRAINDICATION CONTRAINDICATION PRESCRIPTION DRUGS PRESCRIPTION DRUGS Amiodarone Alfuzosin (Xatrol) Norepinephrine Amitriptyline (Elavil) Amantadine Norfloxacin Atomoxetine (Stattera) Aripiprazole (Abilify) Octreotide (Sandostatin) Azithromycin (Zithromax) Atazanavir (Reyataz) Olanzapine (Zyprexa) Chloroquine (Aralen) Bretylium Ofloxacin Chlorpromazine Buprenorphine (BuTrans 5, 10, 20 and in Orciprenaline Ciprofloxacin Suboxone) Orphenadrine (Norflex) Citalopram (Celexa) Chloral hydrate Oxycodone (OxyNEO and in Oxycocet) Clarithromycin Clozapine Oxytocin Clomipramine Cyclobenzaprine, theoretical Paliperidone (Invega) Desipramine Cyclosporin (Neoral) Paroxetine (Paxil) Disopyramide (Rythmodan) Dasatinib (Sprycel) Papaverine Dolasetron (Anzemet) Degarelix (Firmagon) Pazopanib (Votrient) Domperidone Desvenlafaxine (Pristiq) Perflutren lipid microspheres (Definity) Doxepin Dextroamphetamine Perphenazine Dronedarone (Multaq) (Dexedrine and in Adderall) Posaconazole (Posanol) Droperidol Dobutamine Promethazine Erythromycin Donepezil (Aricept) Quinine Escitalopram (Cipralex) Dopamine Quetiapine (Seroquel) Flecainide (Tambocor) Ephedrine Risperidone (Risperdal) Fluconazole Fingolimod (Gilenya) Ritonavir (Norvir) Haloperidol (Haldol) Fluoxetine (Prozac) Ritonavir / Lopinavir (Kaletra) Ibutilide (Corvert) Formoterol (Oxeze Turbuhaler and in Salbutamol (Ventolin) Imipramine Symbicort), theoretical Salmeterol (Serevent and in Advair) Maprotiline Furosemide (Lasix) Sertraline (Zoloft) Methadone (Metadol) Galantamine (Reminyl) Solifenacin (Vesicare) Mexiletine Gatifloxacin (Tequin) Sorafenib (Nexavar) Moxifloxacin (Avelox) Granisetron (Kytril) Spiramycin (Rovamycine) Nortriptyline Hydroxychloroquine (Plaquenil) Sunitinib (Sutent) Ondansetron (Zofran) Hydroxyzine Tacrolimus (Prograf, Protopic) Pentamidine Indapamide (Lozide and in Coversyl Plus) Tamoxifen Pimozide Isoproterenol Terbutaline (Bricanyl Turbuhaler) Procainamide Itraconazole (Sporanox) Thiothixene (Navane) Propafenone (Rythmol) Ketoconazole (Nizoral) Tizanidine (Zanaflex) Propoxyphene Lapatinib (Tykerb) Tolterodine (Detrol) Propofol ( Diprivan, Provoven ) Levofloxacin (Levaquin) Torsemide (Demdex ) Quinidine Lisdexamfetamine (Vyvanse) Trimethoprim / Sulfamethoxazole (Septra) Saquinavir (Invirase) Lithium (Carbolith) Vardenafil (Levitra) Sotalol Mefloquine (Larium) Venlafaxine (Effexor) Trazodone Methylphenidate (Ritalin, Concerta) Voriconazole (VFend) Trimipramine Metoclopramide Vorinostat (Zolinza) Vandetanib (Caprelsa ) Midodrine Ziprasidone (Zeldox) Mirtazapine (Remeron) Nilotinib (Tasigna)
Drugs with RELATIVE/THEORETICAL CONTRAINDICATION (continued) OVER-THE-COUNTER DRUGS Cetirizine (Reactine) , minor Ginseng (Cold – FX) Phenylephrine (Sudafed PE and in Diphenhydramine (Benadryl) , minor Loratidine (Claritin) , theoretical combination Decongestants) Epinephrine (EpiPen, Twinject) (no reports) Pseudoephedrine (Sudafed and in Famotidine (Pepcid) combination Decongestants) STREET DRUGS Amphetamine (bennies, speed, uppers) Methylenedioxy-methamphetamine or MDMA (E, ecstasy, MDA, X) Cocaine (blow, C, coke, crack, rock, snow) Oxycodone (killers, OCs, oxycotton, oxys) Methamphetamine (chalk, crystal meth, ice, meth), Quetiapine (baby heroin, Suzie-Q) [mixed with other drugs]