Diagnosis of Auto-Immune Disorders
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Pathology Antibody Pathology Antibody Systemic disorders Liver Disseminated erythematous Anti-nuclear antibodies Primary biliary cirrhosis Anti-mitochondrial type 2 Ab, pyruvate lupus (DEL) Naive anti-DNA Ab deshydrogenase complex = PDH Anti-nucleosome Ab Anti-gp210 Ab (nuclear pores) Anti-ENA Ab (Sm, RNP, SSA) Anti-SP100 Ab (nuclear dots) Anti-ribosomes Ab Type 1 auto-immune hepatitis Anti-smooth muscle Ab, type anti-actin rd Anti-PCNA Ab Anti-soluble liver antigen Ab = SLA/LP Auto-immune disorders affect over 7% of the population. They are the 3 largest Anti-C1q Ab cause of morbidity in industrialised countries (after cardiovascular diseases and Circulating immune complexes Type 2 auto-immune hepatitis Endoplasmic anti-reticulum Ab = liver and kidney anti-microsomes cancer) and can affect people of any age. Drug-induced lupus Anti-nuclear antibodies = anti-LKM 1) anti-cytochrome-like P450 II D6 Anti-histones Ab Anti-cytosol Ab = anti-LC1 Auto-immune disorders are due to malfunctions of the immune system which result Gougerot-Sjögren Anti-nuclear antibodies Primary sclerosing cholangitis Anti-neutrophil cytoplasmic antibodies, type X or in the manufacture of antibodies, and in some cases, lymphocytes, that act against p-ANCA Syndrome Anti-SSA/Ro 60, SSB Ab the body’s own cells. As a result, each and every organ can be affected. There Anti-SSA/Ro 52 Ab = anti-TRIM 21 are multiple factors accounting for the origin of auto-immune disorders with the Stomach involvement of genetic, endogenetic and environmental factors. Mixed connectivity Anti-nuclear antibodies Anti-RNP Ab Type A gastritic anaemia Intrinsic factor Ab (Biermer's anaemia) Anti-parietal cell antibodies Myositis, Anti-Jo1 Ab Anti H+K+ ATPase Ab Anti-synthetase syndrome Anti-PL7 Ab, PL12, Ku, Mi2 Anti-SRP Ab Anti-Pm-Scl Ab Pancreas Diagnosis of auto-immune disorders Anti-OJ Ab, EJ, TIF/p155/140, MDA-5/CADM 140, Insulin-dependent Anti-islets of Langerhans Ab NXP2, SAE, HMG-coA reductase diabetes Anti-glutamate-decarboxylase Ab = GAD Diagnosis of an auto-immune disorder is based mainly on: clinical symptoms, Exclusion diagnosis DFS 70 Anti-tyrosine-phosphatase Ab = IA2 immunological diagnosis and in some cases, genetic diagnosis. These debilitating Anti-ZnT8 Ab Diffuse systemic scleroderma Anti-nucleolar Ab Anti-Insulin Ab disorders are often severe and at times life-threatening. Often affecting young Anti-ScI70 Ab = topo isomerase subjects, hence the importance of correctly screening for auto-antibodies that are Anti-fibrillarin Ab Auto-immune pancreatitis Anti-lactoferrin and carbonic anhydrase Ab vital for diagnosis in the presence of relevant clinical signs. Anti-RNA polymerase III Ab Overlapping syndrome Anti-Pm-Scl Ab Intestines The auto-immunity serology tests performed by Eurofins Biomnis can assist you Anti-Ku Ab Coeliac disease = gluten Anti-transglutaminase IgA/IgG antibodies Anti-endomysium IgA/IgG Ab in making a quick and reliable diagnosis to improve the treatment of your patients. Anti-centromere Ab (A/B) intolerance Limited systemic scleroderma Anti-gliadin IgA/IgG Ab (formerly CREST syndrome) Anti-Th/To Ab Anti-NOR Ab Crohn’s disease Anti-saccharomyces cerevisiae IgA/IgG Ab = ASCA Antiphospholipid syndrome Anti-β2 glycoprotein 1 IgG/IgM Ab Exocrine anti-pancreas Ab Anti-cardiolipin IgG/IgM Lupus anticoagulant Haemorrhagic rectocolitis Anti-neutrophil cytoplasmic antibodies, type X or Key Anti-phosphatidylethanolamine IgG/IgM Ab p-ANCA Auto-antibodies with a high diagnostic value are shown in blue. Anti-phosphatidylserine IgG Ab Anti-prothrombin IgG Ab Thyroid Anti-annexin V IgG Ab HLA genotyping can be a diagnostic support for several auto-immune Graves' disease Anti-TSH receptor Ab = TSI = LATS = TRAK diseases (for any additional information, please consult our website Rheumatoid polyarthritis Anti-cyclic citrullinated peptide Ab (anti-CCP) Hashimoto thyroiditis, primary Anti-thyroperoxydase Ab = TPO www.biomnis.com). Rheumatoid factors IgM Rheumatoid factors IgA myxoedema Anti-thyroglobulin Ab = Tg Pathology Antibody Pathology Antibody Kidney/Lung Skin Goodpasture syndrome Anti-glomerular basement membrane Ab Pemphigus Anti-intracellular substance antibodies = (not to be confused with anti-epidermal basement desmosomes membrane and intracellular substance antibodies) Anti-desmoglein Ab 1 and 3 Granulomatosis with Anti-neutrophil cytoplasmic Ab (or ANCA), type Bullous pemphigoid Anti-epidermal basement membrane and intracellular polyangitis (also known as anti-proteinase 3 = PR3 substance antibodies (not to be confused with anti- Wegener's granulomatosis) glomerular basement membrane Ab) Gestational pemphigoid Anti-BP 180 Ab Eosinophilic granulomatous, Anti-neutrophil cytoplasmic antibody (or ANCA), Anti-BP 230 Ab microscopic polyangiitis with type anti-myeloperoxydase = MPO Bullous epidermolysis Anti-dermal basement membrane antibodies polyangiitis (formerly Churg Anti-collagen VII Ab and Strauss diseases), extra- capillary glomerulonephritis, Paraneoplastic pemphigus Anti-envoplakin antibodies etc. Herpetiform dermatitis Anti-transglutaminase IgA/IgG antibodies Idiopathic extra-membranous Anti-PLA2R Ab Anti-endomysium IgA/IgG Ab glomerulonephritis Subacute cutaneous lupus Anti-SSA/Ro 60 Ab Adrenal/Ovaries/Testicles Parathyroidism Addison’s disease Anti-adrenal gland antibodies Hypoparathyroidism Anti-calcium sensing receptor (CaSR) Ab Anti-21 hydroxylase Ab Early menopause Hypofertility Anti-ovarian Ab Anti-testicular Ab Eye Retinopathies Anti-retin Ab, recoverin Nervous system Myasthenia Acetylcholine anti-receptor antibodies Anti-MuSK Ab ear/cartilage Anti-striated muscles Ab Cogan syndrome Anti-cochlear Ab Anti-titin Ab Focus on... Meniere’s disease Type 2 anti-collagen Ab Lambert-Eaton myasthenic Anti-Voltage Gated Calcium Channel (VGCC) syndrome antibodies Atrophic polychondritis Type 2 anti-collagen Ab Autoantibodies in the diagnosis Isaacs' syndrome Anti-potassium channel Ab (VGKC), Lgi1 and Caspr2 and follow-up of auto-immune Stiff-man syndrome Anti-glutamate-decarboxylase Ab = GAD To find out more please contact... Anti-amphiphysin Ab Eurofins Biomnis diseases Peripheral neuropathies Anti-myelin Ab International Division Anti-MAG Ab E-mail: [email protected] Anti-gangliosides IgG/IgM Ab (GM1, GM2, GD1a, GD1b, GD3, GT1b, GQ1b, etc.) www.biomnis.com, specialities > Immunology Devic's disease Anti-optic neuromyelitis Ab = aquaporin 4 Multiple sclerosis Anti-MOG Ab Eurofins Biomnis Paraneoplastic syndromes Anti-neurones Ab: Hu, Ri, Yo, amphiphysin, 17/19 avenue Tony Garnier CV2, Ma2, SOX1, zic4, Tr BP 7322 – 69357 LYON Cedex 07 – FRANCE © 123RF/Jakarin Niamklang/Kateryna Kon/Dean Drobot/Eranicle/Shekularaz Limbic encephalitis anti-NMDAr Ab, AMPAr, VGKC, GAD, neurones www.biomnis.com August 2017 DS4-INTGB -.