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Advancing Tissue Science and Engineering

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Advancing Tissue Science and Engineering ADVANCING TISSUE SCIENCE AND ENGINEERING A MULTI-AGENCY StRatEGIC PLAN ABOUT THE MATES IWG The Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group (IWG), organized under the auspices of the Subcommittee on Biotechnology of the National Science and Technology Council (NSTC), is the means by which Federal agencies involved in tissue engineering stay informed of each other’s activities and coordinate their efforts in a timely and efficient manner. The goals of the MATES IWG are: • To facilitate communication across departments/agencies by regular information exchanges and a common website • To enhance cooperation through co-sponsorship of scientific meetings and workshops, and facilitation of the development of standards • To monitor technology by undertaking cooperative assessments of the status of the field • To provide for support of tissue engineering research through interagency tissue engineering funding opportunity announcements For more information, see the MATES website at http://www.tissueengineering.gov. ABOUT THE NATIONAL SCIENCE AND TECHNOLOGY COUNCIL The National Science and Technology Council (NSTC) was established by Executive Order on November 23, 1993. This cabinet-level council is the principal means by which the President coordinates science, space, and technology policies across the Federal Government. NSTC coordinates diverse paths of the Federal research and development enterprise. An important objective of the NSTC is the establishment of clear national goals for Federal science and technology investments in areas ranging from information technologies and health research to improving transportation systems and strengthening fundamental research. The Council prepares research and development strategies that are coordinated across the Federal agencies to form a comprehensive investment package aimed at accomplishing multiple national goals. For more information visit http://www.ostp.gov/nstc/html/NSTC_Home.html. ABOUT THE OFFICE OF SCIENCE AND TECHNOLOGY POLICY The Office of Science and Technology Policy (OSTP) was established by the National Science and Technology Policy, Organization and Priorities Act of 1976. OSTP’s responsibilities including advising the President in policy formulation and budget development on all questions in which science and technology (S&T) are important elements; articulating the President’s S&T policies and programs; and fostering strong partnerships among Federal, state, and local governments, and the scientific communities in industry and academe. Every fiscal year, OSTP and the Office of Management and Budget (OMB) issue a memorandum entitled “Administration Research and Development Budget Priorities.” The memorandum highlights the Administration’s research and development priorities and emphasizes improving management and performance to maintain excellence and leadership in science and technology. The FY ‘08 memorandum is available at http://www.ostp.gov/html/budget/2008/m06-17.pdf. For more information visit http://www.ostp.gov. ABOUT THE OFFICE OF MANAGEMENT AND BUDGET The predominant mission of the Office of Management and Budget (OMB) is to assist the President in overseeing the preparation of the Federal budget and to supervise its administration in Executive Branch agencies. In helping to formulate the President’s spending plans, OMB evaluates the effectiveness of agency programs, policies, and procedures, assesses competing funding demands among agencies, and sets funding priorities. OMB ensures that agency reports, rules, testimony, and proposed legislation are consistent with the President’s Budget and with Administration policies. In addition, OMB oversees and coordinates the Administration’s procurement, financial management, information, and regulatory policies. In each of these areas, OMB’s role is to help improve administrative management, to develop better performance measures and coordinating mechanisms, and to reduce any unnecessary burdens on the public. For more information visit http://www.whitehouse.gov/omb/. ABOUT THIS DOCUMENT This document is a strategic plan for Federal Government investments in tissue science and engineering, including the activities of both research and the regulatory agencies with interests related to tissue engineering or regenerative medicine. The plan was drafted by the members of the MATES IWG, and reviewed and approved by OSTP and NSTC. Central image on front cover, “Mindflower,” courtesy of Ned May. Cover design and layout by Nicolle Rager of Sayo-Art. Advancing Tissue Science and Engineering A Foundation for the Future A Multi-Agency Strategic Plan June 2007 Report prepared by MULTI-AGENCY TISSUE ENGINEERING SCIENCE (MATES) INTERAGENCY WORKING GROUP (IWG) BIOTECHNOLOGY RESEARCH WORKING GROUP SUBCOMITTEE ON BIOTECHNOLOGY COMMITTEE ON SCIENCE NATIONAL SCIENCE AND TECHNOLOGY COUNCIL (NSTC) Department and Agency Contributors Army Medical Research and Materiel National Aeronautics and Space Command (USAMRMC) Administration (NASA) Kenneth Curley, TATRC Steve Davison Eva Lai, TATRC Neal Pellis Robert Vandre, CCCRP National Institutes of Health (NIH) Center for Medicare & Medicaid Services Rosemarie Hunziker, NIBIB (CMS) Christine Kelley, NIBIB James Bowman Nadya Lumelsky, NIDCR Louis B. Jacques, OCSQ Martha Lundberg, NHLBI Joseph Pancrazio, NINDS Defense Advanced Research Projects Agency Fei Wang, NIAMS (DARPA) National Institute for Standards and Jon Mogford Technology (NIST/DOC) Department of Energy (BER/DOE) Mrunal Chapekar, ATP Lori Henderson Peter T. Kirchner Angela Hight Walker Michael V. Viola Andrew Klein, ATP Anne Plant Department of Health and Human Services (HHS) National Science Foundation (NSF) * Howard Zucker Fred Heineken (MATES IWG Chair) Judith Verbeke Environmental Protection Agency (EPA) Elaine Francis Naval Research Laboratory (NRL) Wu Ma Food and Drug Administration (FDA) Charles Durfor, CDRH Office of Science and Technology Policy David Kaplan, CDRH (OSTP/EOP) Brenton McCright, CBER Irma Arispe Richard McFarland, CBER Louisa Chapman† Celia Witten, CBER Diane Jones * Currently at the World Health Organization (WHO), † Currently at the Centers for Disease Control (CDC), Geneva, Switzerland Atlanta, GA Advancing Tissue Science and Engineering EXECUTIVE OFFICE OF THE PRESIDENT NATIONAL SCIENCE AND TECHNOLOGY COUNCIL Washington, D.C. 20502 June 7, 2007 Dear Colleague: I am pleased to transmit this strategic plan for Federal efforts regarding tissue science and engineering. Over the past two decades significant progress has been made toward understanding and harnessing the structure-function relationships in living organisms. Out of this fundamental understanding, a new and burgeoning field, tissue science and engineering, has developed. Applications in medical therapeutics have begun to emerge, under the rubric of regenerative medicine. Non-therapeutic medical uses such as surrogates for animal models in drug discovery and toxicology screening are under development. And tissue science and engineering has led to the development of potentially important non-medical applications such as tissue-based sensors to detect biological or chemical threats. Advancing Tissue Science and Engineering: A Multi-Agency Strategic Plan identifies opportunities for dramatic advances in this and the related field of regenerative medicine. Some specific opportunities include regeneration of lost limbs or organs, rapid identification of deadly biological or chemical agents, reduced reliance on animal testing, and more efficient and less costly drug development and chemical testing. The plan sets four long-term goals for the development of this field as a whole, identifies eight strategic priorities where Federal investments in tissue science and engineering will accelerate progress, and outlines implementation steps that Federal agencies will employ to carry out the plan. This plan was developed by the Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group (IWG) under the Subcommittee on Biotechnology of the Committee on Science of the National Science and Technology Council. The MATES IWG coordinates Federal activities related to tissue science and engineering. The implementation of this plan, under the guidance of the MATES IWG, will contribute significantly to the Administration’s interagency R&D priority on research aimed at improving our understanding of complex biological systems, with multiple agencies supporting highly interdisciplinary research that involves close collaborations among physical, computational, and biological scientists and engineers. The MATES IWG activities outlined in this plan comprise a thoughtful approach for coordinating and prioritizing programs across the Federal Government to ensure full realization of the potential of the field for addressing needs in healthcare, national security and economic vitality. Sincerely, John H. Marburger, III Director, Office of Science and Technology Policy TABLE OF CONTENTS Executive Summary ............................................................................................................. iii 1. Introduction........................................................................................................................1 Evolution of Tissue Science and Engineering ...................................................................1 Commercial and International Interest ..............................................................................3 Need for a Collaborative Federal Agency Effort...............................................................5
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