Do You Know... Caffeine

Total Page:16

File Type:pdf, Size:1020Kb

Do You Know... Caffeine Do You Know... What is it? Caffeine is a stimulant that speeds up your central nervous system. It is the world’s most Caffeine popular drug. Caffeine occurs naturally in products such as coffee, tea, chocolate and cola soft drinks, and is added to a variety of prescription and over-the-counter medications, including cough, cold and pain remedies. Energy drinks may contain both naturally occurring and added caffeine. The following are typical amounts of caffeine in products you may use regularly. (A cup refers to a small take-out cup size of 237 mL [8 oz]. Keep in mind that coffee and tea are often served in much larger cups.) · cup of brewed coffee: 135 mg · cup of instant coffee: 76–106 mg · cup of decaffeinated coffee: about 3 mg · cup of tea: 43 mg · can of regular cola soft drink containing caffeine (355 ml): 36–50 mg · can of energy drink (250 ml): 80 mg · dark chocolate (28 g): 19 mg · milk chocolate (28 g): 7 mg · packet of hot chocolate mix: 7 mg · stay-awake pills: 100 mg 1/4 © 2003, 2011 CAMH | www.camh.ca To find out the amount of caffeine in headache and cold Who uses caffeine? medicines, check the label of over-the-counter medication, Caffeine is the most widely used psychoactive substance or ask your pharmacist about caffeine in prescription drugs. in the world. In North America, more than 80 per cent of adults regularly consume caffeine. The average amount In Canada, manufacturers of products that contain of caffeine consumed per person in Canada (from all naturally occurring caffeine are not required by law to sources) is estimated to be 210 to 238 mg per day. list caffeine as an ingredient on the label. Only added caffeine must be listed. Because some of the caffeine in In Canada, coffee consumption increased from 96 litres energy drinks may come from plant ingredients, such as per person in 1990 to 106 litres per person in 2009. yerba mate (Ilex paraguariensis) and guarana (Paullinia Consumption of tea has also increased, up from 42 litres cupana), caffeine may not be listed on the label. per person in 1990 to 77 litres per person in 2009. Where does caffeine come from? The consumption of energy drinks is also on the rise. Per The words caffeine and coffee are both derived from the capita consumption in Canada was 1.1 litres in 2006, Arabic word qahweh (pronounced “kahveh” in Turkish). up from 0.8 litres in 2001. Energy drinks have become The origins of the words reflect the spread of coffee into popular at parties and dance clubs, and are often used in Europe via Arabia and Turkey from northeast Africa, combination with alcohol. where coffee trees were cultivated in the sixth century. Coffee began to be popular in Europe in the 17th century. How does caffeine make you feel? By the 18th century, plantations had been established in Caffeine stimulates the brain, elevates the mood and Indonesia and the West Indies, and by the 20th century postpones fatigue. It also enhances performance at coffee had become the biggest cash crop on earth. simple intellectual tasks and at physical work that involves endurance, but not fine motor co-ordination. Caffeine was first isolated from coffee in 1819. It is also (Caffeine-caused tremor can reduce hand steadiness.) If found in tea; in cacao pods, and hence in cocoa and you consume caffeine before bedtime, you will likely take chocolate products; in kola nuts, used in the preparation longer to get to sleep, sleep for a shorter time and sleep of cola drinks; in the ilex plant, from whose leaves the less deeply. popular South American beverage yerba mate is prepared; and in guarana seeds, an ingredient in some energy drinks. Contrary to popular belief, drinking coffee will not help you to “sober up” if you’ve had too much alcohol. The The caffeine content of coffee beans varies according caffeine will make you more alert, but your co-ordination to the species of the coffee plant. Beans from Coffea and concentration will still be impaired. arabica, grown mostly in Central and South America, contain about 1.1 per cent caffeine. Beans from Coffea Too much caffeine can give you a headache, upset your robusta, grown mostly in Indonesia and Africa, contain stomach, make you nervous and jittery and leave you about 2.2 per cent caffeine. unable to sleep. It can also cause flushed face, increased urination, muscle twitching and agitation. Some people What does caffeine look like? feel these effects even with a very small amount (in some In its pure form, caffeine is a white, bitter-tasting people as little as 250 mg, or two cups of coffee a day). powder. Larger doses of caffeine, especially when consumed by people who don’t usually take caffeine, can cause rapid heartbeat, convulsions and even delirium. 2/4 | © 2003, 2011 CAMH | www.camh.ca How long does the feeling last? miscarriage and of the baby having a low birth weight. When taken in beverage form, caffeine begins to take Caffeine is excreted in breast milk. Babies of mothers effect within five minutes, and reaches its peak effect in who drink large amounts of caffeine while nursing may be about 30 minutes. It takes about four hours for half of irritable and sleep poorly. Pregnant and nursing women a given dose of caffeine to be metabolized by the body. are advised to limit their caffeine intake to no more than Normally, almost all ingested caffeine is metabolized, 300 mg a day, or a little less than two cups of coffee. and there is no day-to-day accumulation of the drug in the body. Is caffeine addictive? Regular use of caffeine can make you physically Is caffeine dangerous? dependent on caffeine. That means that if you abruptly Moderate amounts of caffeine—up to about 400 mg stop using caffeine-containing products, you may a day (e.g., about three 237 mL cups of coffee)—will feel edgy and tired and have a bad headache. These rarely harm an otherwise healthy adult. But if you symptoms usually appear 18 to 24 hours after the last regularly drink more than six to eight cups of coffee— use of caffeine, and gradually fade over the following or your daily dose of caffeine, from various caffeine- week. containing products, is higher than 600 mg—you may have trouble sleeping and feel anxious and restless. What are the long-term effects of taking caffeine? Higher amounts can cause extreme agitation, tremors Healthy adults do not appear to suffer any long-term and a very rapid and irregular heartbeat. Consuming effects from consuming moderate doses of caffeine daily. more than 5,000 mg over a short time can be fatal. This amount is the equivalent of about 40 cups of coffee. Long-term use of large amounts of caffeine (e.g., four Combining high doses of caffeine with alcohol can be cups of coffee a day) may be associated with loss of dangerous because caffeine can make you feel less bone density, increasing the risk of osteoporosis. Post- intoxicated, so you may continue to drink more or to menopausal women are especially at risk. behave in ways that are risky to you and others. Caffeine use appears to be associated with irregular Energy drinks containing caffeine should not be confused heartbeat and may raise cholesterol levels, but there with sports drinks. When used during periods of intense is no firm evidence that caffeine causes heart disease. physical activity, sports drinks can help to quench thirst, Although caffeine is suspected to be a cause of cancer, while energy drinks can cause dehydration. the evidence is contradictory and does not allow a clear conclusion. Some studies indicate that caffeine can Small amounts of caffeine have a greater effect on cause changes in the cells of the body and in the way children because of their smaller body size. Health these cells reproduce themselves. Canada recommends that caffeine intake from chocolate products, soft drinks and medications be limited to -45 mg for children aged four to six, 62.5 mg for children aged seven to nine and 85 mg for children aged 10 to 12. Older children should limit their intake to 2.5 mg/kg of body weight. Although caffeine has not been proven to cause birth defects, too much caffeine can increase the risk of 3/4 | © 2003, 2011 CAMH | www.camh.ca One in a series... Alcohol GHB Alcohol, Other Drugs Hallucinogens and Driving Heroin Amphetamines Inhalants Anabolic Steroids Ketamine Benzodiazepines LSD Caffeine Methadone Cannabis Methamphetamine Cocaine Prescription Opioids Ecstasy Tobacco For more information on addiction and mental health issues, or to download a copy of this brochure, please visit our website: www.camh.ca This publication may be available in other formats. For information about alternative formats, to order multiple copies of this brochure, or to order other CAMH publications, please contact Sales and Distribution: Toll-free: 1 800 661-1111 Toronto: 416 595-6059 E-mail: [email protected] Online store: http://store.camh.ca To make a donation, please contact the CAMH Foundation: Tel.: 416 979-6909 E-mail: [email protected] If you have questions, concerns or compliments about services at CAMH, please contact the Client Relations Service: Tel.: 416 535-8501 ext. 32028 or 32027 Copyright © 2003, 2011 Centre for Addiction and Mental Health A Pan American Health Organization / World Health Organization Collaborating Centre Fully affiliated with the University of Toronto Disponible en français. 4274e/02-2013 / P263 4/4 | © 2003, 2011 CAMH | www.camh.ca.
Recommended publications
  • Synthetic Cathinones ("Bath Salts")
    Synthetic Cathinones ("Bath Salts") What are synthetic cathinones? Synthetic cathinones, more commonly known as "bath salts," are synthetic (human- made) drugs chemically related to cathinone, a stimulant found in the khat plant. Khat is a shrub grown in East Africa and southern Arabia, and people sometimes chew its leaves for their mild stimulant effects. Synthetic variants of cathinone can be much stronger than the natural product and, in some cases, very dangerous (Baumann, 2014). In Name Only Synthetic cathinone products Synthetic cathinones are marketed as cheap marketed as "bath salts" should substitutes for other stimulants such as not be confused with products methamphetamine and cocaine, and products such as Epsom salts that people sold as Molly (MDMA) often contain synthetic use during bathing. These cathinones instead (s ee "Synthetic Cathinones bathing products have no mind- and Molly" on page 3). altering ingredients. Synthetic cathinones usually take the form of a white or brown crystal-like powder and are sold in small plastic or foil packages labeled "not for human consumption." Also sometimes labeled as "plant food," "jewelry cleaner," or "phone screen cleaner," people can buy them online and in drug paraphernalia stores under a variety of brand names, which include: Flakka Bloom Cloud Nine Lunar Wave Vanilla Sky White Lightning Scarface Image courtesy of www.dea.gov/pr/multimedia- library/image-gallery/bath-salts/bath-salts04.jpg Synthetic Cathinones • January 2016 • Page 1 How do people use synthetic cathinones? People typically swallow, snort, smoke, or inject synthetic cathinones. How do synthetic cathinones affect the brain? Much is still unknown about how synthetic cathinones affect the human brain.
    [Show full text]
  • Study of Adulterants and Diluents in Some Seized Captagon-Type Stimulants
    MedDocs Publishers ISSN: 2638-1370 Annals of Clinical Nutrition Open Access | Mini Review Study of Adulterants and Diluents in Some Seized Captagon-Type Stimulants Ali Zaid A Alshehri1,2*; Mohammed saeed Al Qahtani1,3; Mohammed Aedh Al Qahtani1,4; Abdulhadi M Faeq1,5; Jawad Aljohani1,6; Ammar AL-Farga7 1Department of Medical Laboratory Technology, College of Applied Medical Sciences, University of Jeddah, Saudi Arabia 2Poison Control and Medical Forensic Chemistry Center, Ministry of Health, Riyadh, Saudi Arabia 3Khammis Mushayte Maternity & Children Hospital, Ministry of Health, Saudi Arabia 4Ahad Rufidah General, Hospital, Aseer, Ministry of Health, Saudi Arabia 5Comprehensive Specialized Clinics of Security Forces in Jeddah, Ministry of Interior, Saudi Arabia 6Compliance Department, Yanbu Health Sector, Ministry of Health, Saudi Arabia 7Department of Biochemistry, Faculty of Science, University of Jeddah, Saudi Arabia *Corresponding Author(s): Ali Zaid A Alshehri Department of Medical Laboratory Technology, College of Applied Medical Sciences, University of Jeddah, Saudi Arabia Email: [email protected] Received: Apr 27, 2020 Accepted: Jun 05, 2020 Published Online: Jun 10, 2020 Journal: Annals of Clinical Nutrition Publisher: MedDocs Publishers LLC Online edition: http://meddocsonline.org/ Copyright: © Alshehri AZA (2020). This Article is distributed under the terms of Creative Commons Attribution 4.0 International License Introduction ATS are synthetic compounds belonging to the class of stimu- and heroin users combined [3,4]. Fenethylline, 7-(2-amethyl lants that excite the Central Nervous System (CNS) to produce phenyl-amino ethyl)-theophylline, is a theophylline derivative of adrenaline-like effects such as amphetamine, methamphet- amphetamine. It is a psychoactive drug which is similar to am- amine, fenethylline, methylphenidate and dextroamphetamine phetamine in many ways [5].
    [Show full text]
  • Adenosine Strongly Potentiates Pressor Responses to Nicotine in Rats (Caffeine/Blood Pressure/Sympathetic Nervous System) REID W
    Proc. Nadl. Acad. Sci. USA Vol. 81, pp. 5599-5603, September 1984 Neurobiology Adenosine strongly potentiates pressor responses to nicotine in rats (caffeine/blood pressure/sympathetic nervous system) REID W. VON BORSTEL, ANDREW A. RENSHAW, AND RICHARD J. WURTMAN Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA 02139 Communicated by Walle J. H. Nauta, May 14, 1984 ABSTRACT Intravenous infusion of subhypotensive doses epinephrine output during nerve stimulation is decreased (6). of adenosine strongly potentiates the pressor response of anes- Adenosine can be produced ubiquitously and is present in thetized rats to nicotine. A dose of nicotine (40 jpg/kg, i.v.), plasma and cerebrospinal fluid (7, 8); the nucleoside can which, given alone, elicits a peak increase in diastolic pressure therefore potentially act at a number of different loci, both of -15 mm Hg, increases pressure by -70 mm Hg when arte- central and peripheral, within the complex neural circuitry rial plasma adenosine levels have been increased to 2 puM from involved in the regulation of a single physiological function, a basal concentration of =1 puM. The pressor response to ciga- such as maintenance of blood pressure or heart rate. Neither rette smoke applied to the lungs is also strongly potentiated normal plasma adenosine levels nor the relative and absolute during infusion of adenosine. Slightly higher adenosine con- sensitivities of neural and cellular processes to adenosine centrations (-4 jaM) attenuate pressor responses to electrical have been well characterized in intact animals. The studies stimulation of preganglionic sympathetic nerves, or to injec- described below explore the effects of controlled measured tions of the a-adrenergic agonist phenylephrine, but continue alterations in arterial plasma adenosine concentrations on to potentiate pressor responses to nicotine.
    [Show full text]
  • Narco-Terrorism Today: the Role of Fenethylline and Tramadol
    Narco-terrorism today: the role of fenethylline and tramadol Introduction The relationship between psychoactive substances and violent crimes such as war acts and terrorism dates long back in history. Viking warriors famously fought in a trance-like state, probably as a result of taking agaric "magic" mushrooms and bog myrtle (McCarthy, 2016). More recently, under the German Nazis’ Third Reich, methamphetamine gained an extreme popularity, despite an official “drug-free” propaganda. Under the trademark Pervitin, it could be sold without prescription until 1939, and it was not regulated by the Reich Opium Law of 1941. Pervitin was commonly used in recreational and working settings, and, of course, the stimulant was shipped to German soldiers when the troops invaded France, allowing them to march sleepless for 36 to 50 hours (Ohler, 2016). On the other side, Benzedrine, a racemic mixture of amphetamine initially developed as a bronchodilator, was the stimulant of choice of the Allied forces during World War II (McCarthy, 2016). Vietnam War (1955-1975) is considered to be the first “pharmacological war” of modern history, so called due to an unprecedented high level of consumption of psychoactive substances by military personnel (Kamienski, 2016). In 1971, a report by the House Select Committee on Crime revealed that from 1966 to 1969, the US armed forces had used 225 million tablets of stimulants, mostly Dexedrine (dextroamphetamine), an amphetamine derivative that is nearly twice as strong as the Benzedrine used in the Second World War (Kamienski, 2016). The use of illicit drugs such as stimulants or painkillers by terrorists or insurgents while undertaking their terrorist activities has been hypothesized but still needs further documentation.
    [Show full text]
  • Neuronal Adenosine A2A Receptors Signal Ergogenic Effects of Caffeine
    www.nature.com/scientificreports OPEN Neuronal adenosine A2A receptors signal ergogenic efects of cafeine Aderbal S. Aguiar Jr1,2*, Ana Elisa Speck1,2, Paula M. Canas1 & Rodrigo A. Cunha1,3 Cafeine is one of the most used ergogenic aid for physical exercise and sports. However, its mechanism of action is still controversial. The adenosinergic hypothesis is promising due to the pharmacology of cafeine, a nonselective antagonist of adenosine A1 and A2A receptors. We now investigated A2AR as a possible ergogenic mechanism through pharmacological and genetic inactivation. Forty-two adult females (20.0 ± 0.2 g) and 40 male mice (23.9 ± 0.4 g) from a global and forebrain A2AR knockout (KO) colony ran an incremental exercise test with indirect calorimetry (V̇O2 and RER). We administered cafeine (15 mg/kg, i.p., nonselective) and SCH 58261 (1 mg/kg, i.p., selective A2AR antagonist) 15 min before the open feld and exercise tests. We also evaluated the estrous cycle and infrared temperature immediately at the end of the exercise test. Cafeine and SCH 58621 were psychostimulant. Moreover, Cafeine and SCH 58621 were ergogenic, that is, they increased V̇O2max, running power, and critical power, showing that A2AR antagonism is ergogenic. Furthermore, the ergogenic efects of cafeine were abrogated in global and forebrain A2AR KO mice, showing that the antagonism of A2AR in forebrain neurons is responsible for the ergogenic action of cafeine. Furthermore, cafeine modifed the exercising metabolism in an A2AR-dependent manner, and A2AR was paramount for exercise thermoregulation. Te natural plant alkaloid cafeine (1,3,7-trimethylxantine) is one of the most common ergogenic substances for physical activity practitioners and athletes 1–10.
    [Show full text]
  • Pharmaceuticals and Medical Devices Safety Information No
    Pharmaceuticals and Medical Devices Safety Information No. 296 November 2012 Executive Summary Published by Translated by Pharmaceutical and Food Safety Bureau, Pharmaceuticals and Medical Devices Agency Ministry of Health, Labour and Welfare Office of Safety I For full text version of Pharmaceuticals and Medical Devices Safety Information (PMDSI) No. 296, interested readers are advised to consult the PMDA website for upcoming information. The contents of this month's PMDSI are outlined below. 1. Summary of Payment/Non-payment of Adverse Drug Reaction Relief Benefits and Drugs with Many Cases of Improper Use Under the Relief System for Sufferers from Adverse Drug Reactions, relief benefits have not been approved in some cases due to improper use of drugs. MHLW/PMDA presents here drugs with many cases of improper use and encourages proper use of drugs. 2. Important Safety Information Regarding the revision of the Precautions section of package inserts of drugs in accordance with the Notification dated October 30, 2012, the contents of important revisions and case summaries that served as the basis for these revisions will be provided in section 2 of the full text. 1. Imatinib Mesilate 2. Ceftriaxone Sodium Hydrate 3. Mexiletine Hydrochloride 3. Revision of Precautions (No. 241) Revisions of Precautions etc. for the following pharmaceuticals: Inactivated Poliomyelitis Vaccine, Acetaminophen, Isopropylantipyrine/Acetaminophen/Allylisopropylacetylurea/Anhydrous Caffeine, Tramadol Hydrochloride/Acetaminophen, Salicylamide/Acetaminophen/Anhydrous Caffeine/Chlorpheniramine Maleate, Diprophylline/Dihydrocodeine Phosphate/dl-Methylephedrine Hydrochloride/Diphenhydramine Salicylate/Acetaminophen/Bromovalerylurea, Spironolactone, Dabigatran Etexilate Methanesulfonate, Rotavirus Vaccine, Live, Oral, Pentavalent 4. List of Products Subject to Early Post- marketing Phase Vigilance (as of November 2012) A list of products subject to Early Post-marketing Phase Vigilance as of November 1, 2012 will be provided in section 4 of the full text.
    [Show full text]
  • Convergent Evolution of Caffeine in Plants by Co-Option of Exapted Ancestral Enzymes
    Convergent evolution of caffeine in plants by co-option of exapted ancestral enzymes Ruiqi Huanga, Andrew J. O’Donnella,1, Jessica J. Barbolinea, and Todd J. Barkmana,2 aDepartment of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008 Edited by Ian T. Baldwin, Max Planck Institute for Chemical Ecology, Jena, Germany, and approved July 18, 2016 (received for review March 25, 2016) Convergent evolution is a process that has occurred throughout the the evolutionary gain of traits such as caffeine that are formed via tree of life, but the historical genetic and biochemical context a multistep pathway. First, although convergently co-opted genes, promoting the repeated independent origins of a trait is rarely such as XMT or CS, may evolve to encode enzymes for the same understood. The well-known stimulant caffeine, and its xanthine biosynthetic pathway, it is unknown what ancestral functions they alkaloid precursors, has evolved multiple times in flowering plant historically provided that allowed for their maintenance over mil- history for various roles in plant defense and pollination. We have lions of years of divergence. Second, it is unknown how multiple shown that convergent caffeine production, surprisingly, has protein components are evolutionarily assembled into an ordered, evolved by two previously unknown biochemical pathways in functional pathway like that for caffeine biosynthesis. Under the chocolate, citrus, and guaraná plants using either caffeine synthase- cumulative hypothesis (26), it is predicted that enzymes catalyzing or xanthine methyltransferase-like enzymes. However, the pathway earlier reactions of a pathway must evolve first; otherwise, enzymes and enzyme lineage used by any given plant species is not predict- that perform later reactions would have no substrates with which to able from phylogenetic relatedness alone.
    [Show full text]
  • Caffeine: the Facts
    THE FACTS www.drugaware.com.au ENERGYTEA DRINKS CHOCOLATE COFFEE COLA WHAT IS CAFFEINE? A drug is any substance (with the exception of food and water) which, when taken into E the body, alters its function physically and/or psychologically. Caffeine is one of the most popular drugs, with average consumption estimated to be 70mg per person per day (54% of this is from coffee, 43% from tea and 3% from other forms). Caffeine is a psychoactive drug, meaning it alters mood, thinking and/or behaviour. Caffeine is a stimulant drug. Stimulants increase the body’s state of arousal by speeding up the production of nerve impulses, which increases the activity of the brain. In its purest form, caffeine consists of bitter-tasting crystals. It is found in many common substances like coffee, tea, cocoa, chocolate, cola-flavoured soft drinks and some medical preparations. In Australia, the consumption of energy drinks containing caffeine is increasing. WHERE DOES CAFFEINE COME FROM? The words caffeine and coffee came from the Arabic gahweb. Caffeine was first isolated from coffee in 1821. Coffee originally came from a native plant in Ethiopia and in the fourth century AD was introduced to Arabia and the rest of the East. Ethiopian nomads noticed that their domestic animals became more energetic after eatingRemember, the fruits of growing the trees. and using cannabis is against the law because cannabis is harmful. COLA These nomads discovered that they also felt energised after eating the seeds and began to make a drink by roasting the beans. Coffee has been used in religious ceremonies and rituals, where groups of men would drink excessive amounts and stay up all night praying and chanting.
    [Show full text]
  • Product Information Sheet
    PURINES/PYRIMIDINES LIGAND-SET™ ProductInformation Product Number L2538 Storage Temperature -20°C Product Description The P2Y family is made up of 11 subtypes, P2Y1-11. The Purines/Pyrimidines LIGAND-SET™ is a set of 64 Each receptor binds to a single heterotrimeric G small organic ligands to the Adenosine and Purinergic protein, although the P2Y11 can couple to both Gq/11 and receptors. These ligands are arrayed in a standard 96- Gs. P2Y receptors do not form heteromultimeric well plate, format; each well has a capacity of 1 ml. assemblies with other P2Y subtypes, but many tissues show coexpression of subtypes (e.g., P2Y1 and P2Y2 This set can be used for screening new drug targets, for subpopulations in endothelial cells). The P2Y receptors guiding secondary screens of larger, more diverse show 25-55% homology at the amino acid level. libraries and for standardizing and validating new screening assays. Components/Reagents The Purines/Pyrimidines LIGAND-SET™ contains 2 mg Adenosine receptors are known to consist of four of each ligand per well. Stock solutions can be readily subtypes, A1, A2A, A2B and A3. The majority of the prepared by adding 1 ml of DMSO to each well. The known agonists are derivatives of adenosine. They are set also comes with a diskette containing a structural of interest as potential anti-arrhythmic, cerebro- database, or SD file and a Microsoft Excel file protective and cardioprotective agents via the A1 containing the catalog number, name, rack position and receptor and as hypotensive and antipsychotic agents pharmacological characteristics of each ligand. The via the A2A receptor.
    [Show full text]
  • Synthetic Cathinones (Bath Salts): an Emerging Domestic Threat Cox Broadcasting
    U.S. Department of Justice National Drug Intelligence Center July 2011 Situation Report Product Number 2011-S0787-004 Synthetic Cathinones (Bath Salts): An Emerging Domestic Threat Cox Broadcasting. Cox Broadcasting. Executive Summary The National Drug Intelligence Center (NDIC) assesses with high confidence that the distribu- tion and abuse of synthetic cathinones will increase in the United States in the near term, pos- ing yet another challenge to U.S. law enforcement officials. Poison control centers and medical professionals around the country are increasingly reporting patients suffering adverse physical effects associated with abuse of these drugs, further compounding the problem. Available data and law enforcement reporting suggest increasing levels of synthetic cathinone availability and abuse, but such information is limited and precise levels are unknown. U.S. Cus- toms and Border Protection (CBP) currently tracks seizures of synthetic cathinones at U.S. ports of entry (POEs), but many synthetic cathinone products are disguised or mislabeled to impede detection. Because common field test kits, drug-detecting canines, and routine urine drug screens do not detect synthetic cathinones, law enforcement officials are challenged in interdicting such drugs and prosecuting their manufacturers and distributors. Synthetic Cathinones (Bath Salts): An Emerging Domestic Threat Synthetic cathinones, typically marketed as “bath salts” and “plant food,” are sold legally un- der various names (Ivory Wave, Blizzard, etc.) in most areas of the United States. The products are generally sold in retail establishments such as adult stores, independently owned convenience stores, gas stations, head shops, and skateboard shops. The products, as well as their raw chemi- cal components, are also sold on many Internet sites, including popular Internet auction sites.
    [Show full text]
  • Spice, Bath Salts and Salvia, Oh My!: a Review of “On-Trend” Synthetic Substances of Abuse
    Spice, Bath Salts and Salvia, oh my!: A review of “on-trend” synthetic substances of abuse Snehal Bhatt, MD Assistant Professor, Psychiatry Medical Director, Addiction and Substance Abuse Programs Objectives • Identify the mechanism of action of some prevalent synthetic drugs of abuse. • Recognize the psychological and physiological effects of these substances. • State how emerging drugs of abuse are forever changing and involve manipulation of basic chemical structures to avoid legal ramifications. • Describe some of the management strategies for these substances. EPIDEMIOLOGY- THE PREVALENCE OF SYNTHETIC DRUGS IS RISING Emerging Drug Items Identified in U.S. NFLIS Forensic Labs: 2010-2012 SOURCE: U.S. DEA, Office of Diversion Control, NFLIS data, 2012. 4 Number of Unique Types of Synthetic Drugs Identified Nationally: NFLIS (2010-2012) SOURCE: U.S. DEA, Office of Diversion Control, NFLIS data, 2012. 5 Past Year Drug Use by 12th Grade Students: MTF, 2012 SOURCE: Monitoring the Future Survey, 2012 results. 6 Percentage of U.S. Students (Grades 9 to 12) Reporting Past Year Alcohol and Other Drug Use, 2012 (N=3,884) SOURCE: Adapted by CESAR from The Partnership for a Drug-Free America and the MetLife Foundation, The Partnership Attitude Tracking Study (PATS): Teens and Parents, 2013. 7 "SPICE" [SYNTHETIC CANNABINOIDS] What is it? Is it safe? Anandamide- Endogenous cannabinoid Anandamide- Endogenous cannabinoid • “Ananda” = Sanskrit word meaning bliss, happiness, joy • Anandamide and receptor sites are present in all mammals • Anandamide
    [Show full text]
  • Serum Caffeine and Metabolites Are Reliable Biomarkers of Early Parkinson Disease Motoki Fujimaki, Shinji Saiki, Yuanzhe Li, Et Al
    Published Ahead of Print on January 3, 2018 as 10.1212/WNL.0000000000004888 ARTICLE OPEN ACCESS CLASS OF EVIDENCE Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease Motoki Fujimaki, MD, Shinji Saiki, MD, PhD, Yuanzhe Li, PhD, Naoko Kaga, PhD, Hikari Taka, PhD, Correspondence Taku Hatano, MD, PhD, Kei-Ichi Ishikawa, MD, PhD, Yutaka Oji, MD, Akio Mori, MD, Ayami Okuzumi, MD, Dr. Saiki Takahiro Koinuma, MD, Shin-Ichi Ueno, MD, Yoko Imamichi, BS, Takashi Ueno, PhD, Yoshiki Miura, PhD, [email protected] Manabu Funayama, PhD, and Nobutaka Hattori, MD, PhD or Dr. Hattori [email protected] Neurology® 2018;90:e1-8. doi:10.1212/WNL.0000000000004888 Abstract MORE ONLINE Objective ff Class of evidence To investigate the kinetics and metabolism of ca eine in serum from patients with Parkinson Criteria for rating – disease (PD) and controls using liquid chromatography mass spectrometry. therapeutic and diagnostic studies Methods NPub.org/coe Levels of caffeine and its 11 metabolites in serum from 108 patients with PD and 31 age- matched healthy controls were examined by liquid chromatography–mass spectrometry. RELATED ARTICLE Mutations in caffeine-associated genes were screened by direct sequencing. Editorial Results Caffeine and Parkinson Serum levels of caffeine and 9 of its downstream metabolites were significantly decreased even disease: A possible in patients with early PD, unrelated to total caffeine intake or disease severity. No significant diagnostic and pathogenic genetic variations in CYP1A2 or CYP2E1, encoding cytochrome P450 enzymes primarily breakthrough involved in metabolizing caffeine in humans, were detected compared with controls. Likewise, Page XXX caffeine concentrations in patients with PD with motor complications were significantly de- creased compared with those without motor complications.
    [Show full text]