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The first International Congress of Neuroimmunology was held in Stresa, Italy, in 1982 and wasThe organized first International by Drs. Peter Congress O. Behan of Neuroimmunology and Federico Spreafico. was held The in secondStresa, Italy,International in Congress1982 and of wasNeuroimmunology organized by Drs. was Peter held O.in Philadelphia,Behan and Federico PA, and Spreafico. was organised The second by C.S. Raine andInternational Dale E. McFarlin. Congress It was of atNeuroimmunology this meeting in Philadelphiawas held in inPhiladelphia, 1987 that itPA, was and decided was to startorganised an international by C.S. Raine society, and the Dale International E. McFarlin. Society It was ofat Neuroimmunology,this meeting in Philadelphia and an election wasin 1987held forthat a it panel was decided of officers. to start C.S. anRaine international was elected society, President, the International John Newson-Davis Society Vice President,of Neuroimmunology, Robert Lisak andTreasurer an election and Kenethwas held Johnson for a panel Secretary, of officers. together Cedric with S. an InternationalRaine was Advisoryelected President,Board. The John Society Newson-Davis was incorporated Vice President,in 1988. Subsequent Robert Lisak meetings wereTreasurer in Jerusalem and Kenneth 1991 (Oder Johnson Abramsky Secretary, and togetherHaim Ovadia), with Amsterdaman International 1994 (KeeAdvisory Lucas), Board. Montreal 1998 (Jack Antel and Trevor Owens), Edinburgh 2001 (John Greenwood,The Society Sandra was Amor,incorporated David Baker, in 1988.John -
Late Calcium EDTA Rescues Hippocampal CA1 Neurons from Global Ischemia-Induced Death
The Journal of Neuroscience, November 3, 2004 • 24(44):9903–9913 • 9903 Neurobiology of Disease Late Calcium EDTA Rescues Hippocampal CA1 Neurons from Global Ischemia-Induced Death Agata Calderone, Teresa Jover,* Toshihiro Mashiko,* Kyung-min Noh, Hidenobu Tanaka,† Michael V. L. Bennett, and R. Suzanne Zukin Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461 Transient global ischemia induces a delayed rise in intracellular Zn 2ϩ, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons. The molecular mechanisms underlying Zn 2ϩ toxicity in vivo are not well delineated. Here we show the striking finding that intraventricular injection of the high-affinity Zn 2ϩ chelator calcium EDTA (CaEDTA) at 30 min before ischemia (early CaEDTA) or at 48–60 hr (late CaEDTA), but not 3–6 hr, after ischemia, afforded robust protection of CA1 neurons in ϳ50% (late CaEDTA) to 75% (early CaEDTA) of animals. We also show that Zn 2ϩ acts via temporally distinct mechanisms to promote neuronal death. Early CaEDTA attenuated ischemia-induced GluR2 mRNA and protein downregulation (and, by inference, formation of Zn 2ϩ-permeable AMPARs), the delayed rise in Zn 2ϩ, and neuronal death. These findings suggest that Zn 2ϩ acts at step(s) upstream from GluR2 gene downregulation and implicate Zn 2ϩ in transcriptional regulation and/or GluR2 mRNA stability. Early CaEDTA also blocked mitochondrial release of cytochrome c and Smac/DIABLO (second mitochondria-derived activator of caspases/direct inhibitor of apoptosis protein-binding protein with low pI), caspase-3 activity (but not procaspase-3 cleavage), p75 NTR induction, and DNA fragmentation. -
Department of Neuroscience Faculty Research Interests at the Albert Einstein
Dominick P. Purpura Department of Neuroscience Faculty Research Interests at the Albert Einstein DOBRENIS EMMONS ESKANDER COEN-CAGLI College of Medicine FISHMAN CHUA FRANCESCONI CASTILLO 2019–2020 FRENETTE BUSCHKE FRICKER GALANOPOULOU BUELOW GONÇALVES BERGMAN HALL BENNETT HÉBERT BATISTA-BRITO JORDAN BALLABH KHODAKHAH AUTRY ASCHNER AREZZO KURSHAN ALPERT AKABAS LACHMAN LAROCCA LEGATT LIPTON MEHLER MOLHOLM MOSHÉ NICOLA PEÑA PEREDA ROSS RUDOLPH SCHWARTZ SECOMBE SHARP SINGER SJULSON SOLDNER SPRAY STEINSCHNEIDER SUADICANI SUSSMAN VERSELIS WALKLEY WILSON YANG ZHENG ZUKIN Dominick P. Purpura Department of Neuroscience Faculty Research Interests at the Albert Einstein College of Medicine 2019–2020 Myles Akabas, M.D., Ph.D. 1 Peri Kurshan, Ph.D. 68 Joseph C. Arezzo, Ph.D. 6 Herbert M. Lachman, M.D. 70 Michael Aschner, Ph.D. 8 Jorge N. Larocca, Ph.D. 73 Anita E. Autry, Ph.D. 10 Alan D. Legatt, M.D., Ph.D. 75 Praveen Ballabh, M.D. 12 Michael L. Lipton, M.D., Ph.D. 77 Renata Batista-Brito, Ph.D. 14 Mark F. Mehler, M.D. 81 Michael V. L. Bennett, D.Phil. 16 Sophie Molholm, Ph.D. 83 Aviv Bergman, Ph.D. 18 Solomon L. Moshé, M.D. 89 Herman Buschke, M.D. 24 Saleem M. Nicola, Ph.D. 93 Pablo E. Castillo, M.D., Ph.D. 25 José L. Peña, M.D., Ph.D. 96 Streamson C. Chua, Jr., M.D., Ph.D. 27 Alberto E. Pereda, M.D., Ph.D. 98 Ruben Coen-Cagli, Ph.D. 29 Rachel A. Ross, M.D., Ph.D. 100 Kostantin Dobrenis, Ph.D. 31 Stephanie Rudolph, Ph.D. 102 Scott W. -
TLN Agenda-101507
Fall 2007 Janelia Conference: Translation at the Synapse Full Schedule Sunday, October 21st 3:00 pm Check-in 6:00 pm Reception 7:00 pm Dinner 8:00 pm Session 1 (chair - Kevin Moses) 8:00 pm Oswald Steward, University of California, Irvine Mechanisms underlying the selective localization of Arc mRNA at active synapses 8:30 pm James Eberwine, University of Pennsylvania School of Medicine Molecular Biology of the Neuronal Dendrite 9:00 pm Robert Singer, Albert Einstein College of Medicine Following single mRNAs from birth to translation 9:30 pm Erin Schuman, California Institute of Technology/HHMI Visualization of dendritic protein synthesis 10:00 pm Refreshments available at Bob’s pub Fall 2007 Janelia Conference: Translation at the Synapse Monday, October 22nd 7:30 am Breakfast 8:30 am Session 2 (chair - Erin Schuman) 8:30 am Michael Kiebler, Medical University of Vienna The role of Staufen in dendritic RNP transport and dendritic spine morphogenesis 9:00 am Nobutaka Hirokawa, University of Tokyo Intracellular transport of mRNA and kinesin superfamily proteins, KIFs 9:30 am Mark F. Bear, Massachusetts Institute of Technology/HHMI Fragile X syndrome: A disease of synaptic protein synthesis 10:00 am Suzanne Zukin, Albert Einstein College of Medicine AMPA receptor mRNA trafficking in dendrites and synaptic plasticity: dysregulation in Fragile X 10:30 am Break and Group Photo 11:00 am Gary J. Bassell, Emory University School of Medicine Dysregulated mGluR-dependent translation of AMPA receptor and PSD- 95 mRNAs in fragile x syndrome 11:30 am Tom Jongens, University of Pennsylvania School of Medicine Regulation of the Drosophila Fragile X mental retardation gene by the siRNA pathway 12:00 pm Claudia Bagni, University of Rome Translational control at synapses and mental retardation: new insights into the Fragile X Syndrome 12:30 pm Lunch 1:00 pm Tour 2:00 pm Session 3 (chair - Mark F. -
Plasma from Human Mothers of Fetuses with Severe Arthrogryposis Multiplex Congenita Causes Deformities in Mice
Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice Leslie Jacobson, … , Gillian Morriss-Kay, Angela Vincent J Clin Invest. 1999;103(7):1031-1038. https://doi.org/10.1172/JCI5943. Article Arthrogryposis multiplex congenita (AMC) is characterized by fixed joint contractures and other deformities, sometimes resulting in fetal death. The cause is unknown in most cases, but some women with fetuses affected by severe AMC have serum antibodies that inhibit fetal acetylcholine receptor (AChR) function, and antibodies to fetal antigens might play a pathogenic role in other congenital disorders. To investigate this possibility, we have established a model by injecting pregnant mice with plasma from four anti-AChR antibody–positive women whose fetuses had severe AMC. We found that human antibodies can be transferred efficiently to the mouse fetus during the last few days of fetal life. Many of the fetuses of dams injected with AMC maternal plasmas or Ig were stillborn and showed fixed joints and other deformities. Moreover, similar changes were found in mice after injection of a serum from one anti-AChR antibody–negative mother who had had four AMC fetuses. Thus, we have confirmed the role of maternal antibodies in cases of AMC associated with maternal anti-AChR, and we have demonstrated the existence of pathogenic maternal factors in one other case. Importantly, this approach can be used to look at the effects of other maternal human antibodies on development of the fetus. Find the latest version: https://jci.me/5943/pdf Plasma from human mothers of fetuses with severe arthrogryposis multiplex congenita causes deformities in mice Leslie Jacobson,1 Agata Polizzi,1 Gillian Morriss-Kay,2 and Angela Vincent1 1Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom 2Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. -
Bearing Witness to Female Trauma in Comics: An
BEARING WITNESS TO FEMALE TRAUMA IN COMICS: AN ANALYSIS OF WOMEN IN REFRIGERATORS By Lauren C. Watson, B.A. A thesis submitted to the Graduate Council of Texas State University in partial fulfillment of the requirements for the degree of Master of Arts with a Major in Literature May 2018 Committee Members: Rebecca Bell-Metereau, Chair Rachel Romero Kathleen McClancy COPYRIGHT by Lauren C. Watson 2018 FAIR USE AND AUTHOR’S PERMISSION STATEMENT Fair Use This work is protected by the Copyright Laws of the United States (Public Law 94-553, section 107). Consistent with fair use as defined in the Copyright Laws, brief quotations from this material are allowed with proper acknowledgement. Use of this material for financial gain without the author’s express written permission is not allowed. Duplication Permission As the copyright holder of this work I, Lauren C. Watson, refuse permission to copy in excess of the “Fair Use” exemption without my written permission. DEDICATION For my Great Aunt Vida, an artist and teacher, who was the star of her own story in an age when women were supporting characters. She was tough and kind, stingy and giving in equal measures. Vida Esta gave herself a middle name, because she could and always wanted one. Ms. Light was my first superheroine and she didn’t need super powers. ACKNOWLEDGMENTS Three years ago, I woke up in the middle of the night with an idea for research that was daunting. This thesis is the beginning of bringing that idea to life. So many people helped me along the way. -
WCBR Program3
Welcome to the Thirty-Fifth Annual Winter Conference on Brain Research The Winter Conference on Brain Research (WCBR) was founded in 1968 to promote free exchange of information and ideas within neuroscience. It was the intent of the founders that both formal and informal interactions would occur between clinical and laboratory based neuroscientists. During the past thirty years neuroscience has grown and expanded to include many new fields and methodologies. This diversity is also reflected by WCBR participants and in our program. A primary goal of the WCBR is to enable participants to learn about the current status of areas of neuroscience other than their own. Another objective is to provide a vehicle for scientists with common interests to discuss current issues in an informal setting. On the other hand, WCBR is not designed for presentations limited to communicating the latest data to a small group of specialists; this is best done at national society meetings. The program includes panels (reviews for an audience not neces- sarily familiar with the area presented), workshops (informal discussions of current issues and data), and a number of posters. The annual conference lecture will be presented at the Sunday breakfast on Sunday, January 27. Our guest speaker will be Dr. Donald Kennedy, Editor-in-Chief of Science. On Tuesday, January 29, a town meeting will be held for the Aspen/Snowmass commu- nity at which Dr. George Ricaurte, and WCBR participants will discuss drug addiction and toxicity of addictive drugs. Also, participants in the WCBR Outreach Program will present sessions at local schools throughout the week to pique students’ interest in science. -
Hawkman in the Bronze Age!
HAWKMAN IN THE BRONZE AGE! July 2017 No.97 ™ $8.95 Hawkman TM & © DC Comics. All Rights Reserved. BIRD PEOPLE ISSUE: Hawkworld! Hawk and Dove! Nightwing! Penguin! Blue Falcon! Condorman! featuring Dixon • Howell • Isabella • Kesel • Liefeld McDaniel • Starlin • Truman & more! 1 82658 00097 4 Volume 1, Number 97 July 2017 EDITOR-IN-CHIEF Michael Eury PUBLISHER John Morrow Comics’ Bronze Age and Beyond! DESIGNER Rich Fowlks COVER ARTIST George Pérez (Commissioned illustration from the collection of Aric Shapiro.) COVER COLORIST Glenn Whitmore COVER DESIGNER Michael Kronenberg PROOFREADER Rob Smentek SPECIAL THANKS Alter Ego Karl Kesel Jim Amash Rob Liefeld Mike Baron Tom Lyle Alan Brennert Andy Mangels Marc Buxton Scott McDaniel John Byrne Dan Mishkin BACK SEAT DRIVER: Editorial by Michael Eury ............................2 Oswald Cobblepot Graham Nolan Greg Crosby Dennis O’Neil FLASHBACK: Hawkman in the Bronze Age ...............................3 DC Comics John Ostrander Joel Davidson George Pérez From guest-shots to a Shadow War, the Winged Wonder’s ’70s and ’80s appearances Teresa R. Davidson Todd Reis Chuck Dixon Bob Rozakis ONE-HIT WONDERS: DC Comics Presents #37: Hawkgirl’s First Solo Flight .......21 Justin Francoeur Brenda Rubin A gander at the Superman/Hawkgirl team-up by Jim Starlin and Roy Thomas (DCinthe80s.com) Bart Sears José Luís García-López Aric Shapiro Hawkman TM & © DC Comics. Joe Giella Steve Skeates PRO2PRO ROUNDTABLE: Exploring Hawkworld ...........................23 Mike Gold Anthony Snyder The post-Crisis version of Hawkman, with Timothy Truman, Mike Gold, John Ostrander, and Grand Comics Jim Starlin Graham Nolan Database Bryan D. Stroud Alan Grant Roy Thomas Robert Greenberger Steven Thompson BRING ON THE BAD GUYS: The Penguin, Gotham’s Gentleman of Crime .......31 Mike Grell Titans Tower Numerous creators survey the history of the Man of a Thousand Umbrellas Greg Guler (titanstower.com) Jack C. -
WCBR Program 04
Welcome to the Thirty-Seventh Annual Winter Conference on Brain Research The Winter Conference on Brain Research (WCBR) was founded in 1968 to promote free exchange of information and ideas within neuroscience. It was the intent of the founders that both formal and informal interactions would occur between clinical and laboratory-based neuroscientists. During the past thirty years neuroscience has grown and expanded to include many new fields and methodologies. This diversity is also reflected by WCBR participants and in our program. A primary goal of the WCBR is to enable participants to learn about the current status of areas of neuroscience other than their own. Another objective is to provide a vehicle for scientists with common interests to discuss current issues in an informal setting. On the other hand, WCBR is not designed for presentations limited to communicating the latest data to a small group of specialists; this is best done at national society meetings. The program includes panels (reviews for an audience not neces- sarily familiar with the area presented), workshops (informal discussions of current issues and data), and a number of posters. The annual conference lecture will be presented at the Sunday breakfast on January 25. Our guest speaker will be The Honorable John Edward Porter, former Congressman from Illinois and Chair of the House Appropriations Committee. The title of his talk will be What’s Going on in Washington: We Need to Talk! On Tuesday, January 27, a town meeting will be held for the Copper Mountain community, at which Dr. Michael Zigmond, Director of the Morris K. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
Autoimmune Encephalitis
Autoimmune encephalitis Angela Vincent and the Neurosciences Group Nuffield Department of Clinical Neurosciences, Oxford University, UK Disclosures Angela Vincent and the University of Oxford hold patents, and receive royalties and payments for antibody tests including VGKC-complex antigens LGI1 and CASPR2 Angela Vincent has recently received honoraria for lectures from GSK, UCB Pharma and Serono This is the version that should have been presented – slightly different from that you saw Autoantibodies causing neurological diseases From myasthenia to encephalitis and a growing number of wider conditions The neuromuscular junction in myasthenia AChRs Muscle fibre Antibodies cause loss of the AChRs Patients improve with treatments that reduce the AChR antibody levels Plasma exchange for myasthenia John Newsom-Davis Newsom-Davis et al 1978 1932-2007 Crisp, Kullmann and Vincent Nature Reviews Neuroscience 2016 Antibody-mediated diseases Antibodies that bind to extracellular domain of membrane protein on target tissue Antibodies measured easily in serum (and cerebrospinal fluid (CSF) if relevant) Antibodies cause loss of the target protein and/or damage to the cell Patients can improve with immunotherapies: steroids, plasma exchange, intravenous immunoglobulins Pathogenicity can be demonstrated by animal studies MG with MuSK antibodies, AChR antibodies negative Plasma exchange provided a diagnostic test! But long-term marked and persistent facial weakness and atrophy, difficult to treat Patient of John Newsom-Davis; courtesy of patient MuSK-MG -
Supporting Tomorrow's Leaders Today
Supporting tomorrow’s leaders today The Academy of Medical Sciences’ mentoring scheme for postdoctoral clinical academics Contents 04 Foreword 07 Author’s preface 08 What is mentoring? 10 A focus on future leaders in academic medicine 13 What is the Academy’s approach? 14 How does mentoring operate in the Academy scheme? 16 What benefits does mentoring offer? 18 Reflections on the scheme from mentees 20 Reflections on the scheme from mentors 24 But does mentoring work? 28 Which organisations are best placed to coordinate mentoring? 30 Principles to create an environment for effective mentoring 32 Reflections and directions The Academy of Medical Sciences promotes advances in medical The Academy is grateful to the many Fellows and staff who have science and campaigns to ensure these are converted into helped in the continuing development of the Academy’s mentoring healthcare benefits for society. The Academy seeks to play a pivotal scheme. We thank our main supporters, the Department of Health role in determining the future of medical science in the UK and the and the National Institute for Health Research, in particular, benefits that society will enjoy in years to come. Professor Dame Sally C. Davies FMedSci for her personal interest. We champion the UK’s strengths in medical science, promote We also thank organisations in the devolved administrations for careers and capacity building, encourage the implementation of their support to date: new ideas and solutions – often through novel partnerships – and • NHS Education for Scotland help to remove barriers to progress. • National Institute for Social Care and Health Research (Wales) • Queen’s University Belfast Foreword The Academy is passionate about supporting excellent In 2010, we commissioned an external evaluation of the young researchers who are future leaders and innovators mentoring scheme with very positive results.