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First in Man SESAME Stent Trial Demonstrates 100% Acute Success First in Man SESAME Stent Trial Demonstrates 100% Acute Success Rate 3 Dressing indicates infections 5 Cultured kidney cell layer is a step towards improved dialysis 7 Research into the scientific potential of time of flight cameras 9 Disease tracking - is there an app for that? 11 Risø Energy Report 9: CO2-free energy can meet the world’s energy needs in 2050 12 Researchers map the way to personalised treatment for ovarian cancer 13 Smoke from fireworks is harmful to health 15 Scientists identify potential new target for treating triple negative breast cancer 17 A new search engine links biomedical articles to nucleic acid sequences 19 Need for transparency on the Web 20 Size of hippocampus may indicate early dementia 21 Appearance not always enough to identify species 22 Newly discovered drumlin field provides answers about glaciation and climate 24 We're used to windy conditions 26 Rational family structure dominates 28 Active management of the third stage of labour reduces risk of bleeding 30 Saving our data from digital decay 32 Homecoming for Stark Record of Apartheid 34 ‘Magic number’ 695 opens up new areas for Alzheimer’s research 37 Synchrotron reveals human children outpaced Neanderthals by slowing down 39 Antimatter Atoms Stored for the First Time 41 Stunning Details of Brain Connections Revealed 45 Language May Help Create, Not Just Convey, Thoughts and Feelings 48 Length of Pregnancy Influenced by Placenta Structure 50 Damaged Organs Linked to Change in Biochemical Wave Patterns 52 Putting the Chinese in ‘Made in China’ 54 Adult Stem Cells With Simultaneous Chemical, Electrical and Mechanical Cues 56 Caribbean Reef Ecosystems May Not Survive Repeated Stress 59 Astronomers Discover Merging Star Systems That Might Explode 61 Earth's Lower Atmosphere Is Warming, 63 Global Warming Could Cool Down Northern Temperatures in Winter 65 Small Clumps of Tau Protein Disrupt Memory 67 Low-Allergenic Wines Could Stifle Sniffles and Sneezes in Millions of Wine Drinkers 68 Development of a Safer Vaccine for Alzheimer’s Disease 70 Deepwater Horizon: Not Managing Danger, Not Learning from 'Near Misses' 71 How Anthrax Bacteria Impair Immune Response 73 Stealing Mother Nature’s Thunder 74 Baking Soda Dramatically Boosts Oil Production in Algae 77 Infant Estrogen Levels Tracked Through Diaper Research 80 Design for Human-Made Light Trapping Device Could Help Harvest Light for Solar Cells 83 New 3-D Model of RNA 'Core Domain' of Enzyme Telomerase May Offer Clues to Cancer 84 Landing Lights for Bumblebees 88 Sistema de Infotecas Centrales Universidad Autónoma de Coahuila New Device Detects Insects in Stored Wheat 90 Critically Endangered Tree Frog Bred for First Time 91 Playing the Renegade With Eroticism or Rage 93 Hearing Loss Study Reveals Role of Bone Hardness in Tissue Function 96 Physicists Demonstrate a Four-Fold Quantum Memory 99 Mortal Chemical Combat Typifies the World of Bacteria 102 Scientists Identify Antivirus System 104 Cholesterol-Lowering Statins Boost Bacteria-Killing Cells 106 The Controversial Whitney Museum 108 Laser System Shows Promise for Cataract Surgery 110 As Arctic Temperatures Rise, Tundra Fires Increase 113 New Technology Gives on-Site Assessments in Archaeology 115 Multiple Sclerosis Drug Serves as Model for Potential Drugs to Treat Botulism Poisoning 117 Faster Water Flow Means Greater Diversity of Invertebrate Marine Life 118 Sonar Inspired by Dolphins 120 One of France's Largest Dinosaur Fossil Deposits Found in the Charente Region 125 How Do Folded Structures Form? 127 Breakthrough Could Help Reduce Heating of Plasma Container Walls 129 Film of Paul Bowles Short Story Rediscovered 131 Astronomers Discover Merging Star Systems That Might Explode 134 How the Songbird's Brain Controls Timing During Singing 136 Engineers Test Effects of Fire on Steel Structures 138 The Workout Enigma 140 US reserves of rare earth elements assessed for first time 142 Red wine packed with antidiabetes compounds 144 In Fending Off Diseases, Plants and Animals Are Much the Same, Research Shows 146 Physicists Demonstrate a Four-Fold Quantum Memory 148 As Glaciers Melt, Science Seeks Data on Rising Seas 151 Worm Can Deal Double Blow to Nuclear Program 159 A Costly Quest for the Dark Heart of the Cosmos 160 What if Captured Carbon Makes a Getaway? 164 Surprise at a Comet Visited by NASA: A Snowstorm 165 Accelerator supercomputers dominate newest Green 500 List’s Top 10 167 A New Take on Computer Security 169 Stem cells from amniotic fluid 171 Understanding ageing by studying reproduction! 172 Eating a variety of fruit cuts lung cancer risk 173 The incredible impact of stars on culture 175 Perceptual changes – a key to our consciousness 176 Trained bacteria convert bio-wastes into plastic 177 Abnormal blood values indicate increased mortality in PEG-operations 179 Biochemistry of how plants resist insect attack determined 181 Appalachians in the limelight 183 A history of Earth's convulsions 185 Online map of maternal health to inform and influence world leaders 187 Population reproduction pattern in Bulgaria and its impact on labour force (2005-2030) 189 Researchers insert identification codes into mouse embryos 191 Experimental evidence of a novel magneto-sensitive effect in conducting materials 193 Organ Procurement Air Transportation Displays Poor Safety Record 196 Conductor paths for marvelous light 198 Spearheading British eco-homes 200 2 Infoteca’s E-Journal No. 138 December 2010 Sistema de Infotecas Centrales Universidad Autónoma de Coahuila First in Man SESAME Stent Trial Demonstrates 100% Acute Success Rate Wiley - Blackwell Low 30-Day MACE Rate and 9-Month Patency Comparable to Balloon Expandable Stents A new study revealed that the novel self-expanding super-elastic all-metal endoprosthesis stent (SESAME StentTM) used in patients undergoing angioplasty of degenerated saphenous vein graft (SVG) lesions has 100% acute success, low 30 day major adverse cardiac events (MACE) rates, and 9-month patency comparable to balloon expandable stents without embolic protection. Results of the study are published in the November issue of Catheterization and Cardiovascular Intervention, a peer-reviewed journal from The Society for Cardiovascular Angiography and Interventions. Percutaneous coronary intervention (PCI), or angioplasty, is a procedure to alleviate plaque buildup due to atherosclerosis. A thin catheter containing a small balloon is inserted into an artery and threaded toward the heart to the blockage. The balloon is then inflated to push back the plaque and restore blood flow to the heart, and a wire mesh tube called a stent is usually put in place to prevent re-blocking. PCI of old, degenerated saphenous vein grafts (SVGs) is a challenging and risky procedure. Diseased SVGs are complicated, thrombotic lesions associated with a higher risk of plaque and thrombus embolization, making the placement of embolic distal protection devices during PCI difficult. Up to half of patients with SVGs receiving bare metal stents have restenosis or occlusion within 6–12 months following stent implantation. There are no self-expanding stents specifically used to treat SVG disease. Prior adjunctive therapies such as antiplatelet agents and covered stents have not been effective in improving procedural outcomes of SVG PCI. The Advanced Bioprosthetic SurfacesTM SESAME stent offers a system that limits plaque protrusion through the stent struts and limits stent strut migration into the underlying plaque. The microporous mesh of the SESAME stent is an improvement over the polymer covers used in other stents for SVG implantation because it allows improved vascular healing and tissue regrowth over the sent (endothelialization). Biocompatibility studies indicate metals are advantageous over polymers, suggesting that a metal membrane should be a good choice for a covered-stent. The SESAME First in Man trial is a prospective, multicenter registry of 20 nonrandomized consecutive patients with 21 stenotic SVGs treated electively at two centers between February 2005 and August 2005. Patients underwent elective intervention of symptomatic SVG lesions with 50% stenosis. PCI was performed without embolic protection devices. “The SESAME trial is the first study to prospectively demonstrate that a self-expanding microporous membrane-covered stent can be safely used with a high success rate in treating complex SVG lesions even in the absence of embolic protection devices,” comments study leader Steven R. Bailey, MD, FSCAI, from the University of Texas Health Sciences Center in San Antonio. Technical success—successful crossing of the lesion and deployment of the device—was achieved in 100% of lesions using the SESAME stent. A 100% procedural success rate, defined as a residual stenosis of less than 50% stenosis post stent and no MACE, was also achieved. No procedural or in hospital complications occurred. Follow-up was present in 20 patients at 30 days, with clinical and angiographic evaluation at 9 months. No MACE events occurred at 30 days. At 9 months, 3 patients underwent repeat PCI. Dr. Bailey concluded, “Even in severely degenerate SVG lesions, 3 Infoteca’s E-Journal No. 138 December 2010 Sistema de Infotecas Centrales Universidad Autónoma de Coahuila interventionists can safely achieve a high primary success rate with low MACE during the initial 30 days following the procedure.” For more information, please visit: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-726X.. http://www.alphagalileo.org/ViewItem.aspx?ItemId=89843&CultureCode=en 4 Infoteca’s E-Journal No. 138 December 2010 Sistema de Infotecas Centrales Universidad Autónoma de Coahuila Dressing indicates infections Fraunhofer-Gesellschaft Wounds have to be regularly checked, to make sure any complications in the healing process are detected at an early stage. A new material will make it possible to check wounds without changing the dressing: If an infection arises, the material changes its color. Whether a small cut with a fruit knife, a surgical wound or a major injury caused by a fall – the body’s defense and repair system leaps into action and tries to close the wound as quickly as possible.
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