Final Program
Total Page:16
File Type:pdf, Size:1020Kb
HUPO 2018 17th Annual World Congress of the Human Proteome Organization September 30 to October 3, 2018 -PFXT3PZBM1BDJñDr0SMBOEP '-r64" HPP Post-Congress Day, October 4 FINAL PROGRAM www.hupo2018.org www.mcponline.org Your technological advances belong here. Molecular & Cellular Proteomics is the home for papers describing new, impactful technologies that make substantial contributions to the understanding of proteomics. The editors of MCP are eager to publish papers about automation of sample preparation protocols, micro-scaling approaches, targeted protein identification and quantitation methods, and other technological advances. Get your work noticed by publishing with MCP. Published by +333RVW&RQJUHVV'D\2FWREHU :HOFRPHDQG&RPPLWWHH +832*RYHUQDQFH *HQHUDO,QIRUPDWLRQ 0DSRI0HHWLQJ6SDFH +832$ZDUGV 0DMRU6SRQVRUV ([KLELWRUV 3URJUDP2YHUYLHZ 6XQGD\(YHQLQJ2SHQLQJ3URJUDP 0RQGD\3URJUDP 7XHVGD\3URJUDP :HGQHVGD\3URJUDP 3RVWHU/LVW 3RVWHUV $XWKRU,QGH[ The HUPO 17th Annual World Congress is co-sponsored by US HUPO and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¶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±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iodesign Institute, Princeton University Institute for Systems The Scripps Research University of Arizona Biology Institute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¡UUHJDDUG-HQVHQ 6DQMHHYD6ULYDVWDYD ,OHDQD&ULVWHD 6HWVXNR.RPDWVX 3LHUUH7KLEDXOW *LOEHUWR'RPRQW 0DUWLQ/DUVHQ $QGUHD8UEDQL 9LWRU)Do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x 3/(1$5< $1' 3$5$//(/ 25$/ 6(66,216 DUH ORFDWHG LQ WLFNHW SXUFKDVH UHTXLUHG 7LFNHWV PD\ EH SXUFKDVHG DW WKH2FHDQD%DOOURRPFRPSOH[ UHJLVWUDWLRQWKURXJKSP0RQGD\ x &25325$7(/81&+6(0,1$56$1'(9(176PD\EHIRXQG LQWKH([KLELWRUOLVWLQJSDJHV± +$//2:((1 +25525 # 81,9(56$/ 30 :('1(6'$< x 3267(56 $1' (;+,%,7 %227+6 DUH LQ WKH 3DFLILFD 8QLYHUVDOSDUNLVRSHQIRUVSHFLDO+DOORZHHQ+RUURUQLJKWRQ %DOOURRP :HGQHVGD\:HKDYHWLFNHWVDYDLODEOHIRUSXUFKDVHDW x ,1129$7,21 67$*( LV ORFDWHG LQ WKH 3DFLILFD %DOOURRP UHJLVWUDWLRQFRXQWHU0HHWXSSPRQ:HGQHVGD\WRJR ZLWKWKHH[KLELWVDQGSRVWHUV WR WKH SDUN DV D JURXS +DOORZHHQ +RUURU QLJKW ZLOO KDYH x 5(*,675$7,21LVRSHQDPSP6XQGD\ µIULJKWV¶ WKURXJKRXW WKH SDUN ZLWK VRPH VSHFLDO KDXQWHG DPSP0RQGD\:HGQHVGD\ KRXVH+DUU\3RWWHUDWWUDFWLRQVZLWKLQ8QLYHUVDOZLOOEHIXOO\ IXQFWLRQDODQGDUHQRQIULJKW-RLQXVWREORZRIIVRPHSRVW )UHHZLILLVDYDLODEOHORRNIRUVLJQVDWWKHFRQJUHVVZLWKVLJQ FRQJUHVVVWHDP LQGHWDLOV &21*5(665(*8/$7,216 352*5$0&2'(6IRUWDONVDUHDVIROORZV x 1DPHEDGJHVDUHUHTXLUHGIRUDOOFRQIHUHQFHVHVVLRQV 07: 'D\ LQFOXGLQJWKHH[KLELWKDOO 2 2UDO x 1RVPRNLQJLVSHUPLWWHGLQVLGHWKHKRWHO $%&'( 6HVVLRQ x &HOOSKRQHVPXVWEHWXUQHGRIILQRUDOVHVVLRQV 7LPH x 1R SKRWRJUDSK\ RU UHFRUGLQJ LQ DQ\ VHVVLRQ For example 02$ DP 0RQGD\ 2UDO 6HVVLRQ $ DW LQFOXGLQJSRVWHUV DP x 7KHSODFHPHQWRIDGYHUWLVLQJLQWKHPHHWLQJDUHDLV )RUSRVWHUVµ3RVWHU¶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x 2GGQXPEHUHGERDUGVSUHVHQWRQ0RQGD\ x (YHQQXPEHUHGERDUGVSUHVHQWRQ7XHVGD\ x $OOSUHVHQWHUVRQ:HGQHVGD\PRUQLQJ %,2,1)250$7,&6+8%ZLOOKDYHSURJUDPV6XQGD\WKURXJK :HGQHVGD\QRRQLQ3DFLILFD%DOOURRP)RUGHWDLOVYLVLW https://github.com/CompMS/Overview/wiki/HUPO-2018 /2(:652<$/3$&,),&0((7,1*63$&(0$33/$1 6LGHZDON3URPHQDGHWRKRWHOJXHVWURRPWRZHUV (QWHUKHUH 5HJLVWUDWLRQ ,QQRYDWLRQ 6WDJH 3267(56 (;+,%,76 %LRLQIRUPDWLFV +XE 2FHDQD 2FHDQD 2FHDQD 2FHDQD 6HVVLRQ$ 6HVVLRQ% 3OHQDULHV 6HVVLRQ' 6HVVLRQ& 2FHDQD 6SHDNHU 2FHDQD 5HDG\5RRP 6HVVLRQ( 2FHDQD +832$:$5'6 ',67,1*8,6+('$&+,(9(0(17,13527(20,&6&,(1&(6 6SRQVRUHGE\-RXUQDORI3URWHRPH5HVHDUFK $&63XEOLFDWLRQV .DWKU\Q/LOOH\ University of Cambridge, UK 'U/LOOH\SURYLGHVOHDGLQJHIIRUWVLQGHYHORSLQJWHFKQRORJLHVWRHQDEOHWKHPHDVXUHPHQWRISURWHRPHG\QDPLFV LQDKLJKWKURXJKSXWPDQQHULQVSDFHDQGWLPHGXULQJFHOOXODUSURFHVVHV7KHVHLQFOXGHPHWKRGVIRUGHILQLQJ G\QDPLF SURWHLQ DQG SURWHLQFRPSOH[ VXEFHOOXODU ORFDWLRQ FDOOHG ³/RFDOL]DWLRQ RI 2UJDQHOOH 3URWHLQV XVLQJ ,VRWRSH7DJJLQJ´ /23,7 DQGPRUHUHFHQWO\K\SHU/23,72WKHUPHWKRGVGHYHORSHGE\'U/LOOH\HQFRPSDVV PDSSLQJWKHORFDWLRQRIWUDQVODWLRQRISURWHLQVDQGWKHLUFRQWURO0XOWLSURWHLQFRPSOH[HVZLWKQRYHOSURWHLQSURWHLQ LQWHUDFWLRQPHWKRGVXVLQJ3DUDOOHO$IILQLW\&DSWXUH L3$& DQG6HOHFWLYH3URWHRPLF3UR[LPLW\/DEHOLQJXVLQJ7\UDPLGH 633/$7 DPHWKRGWKDWHQDEOHVWKHLGHQWLILFDWLRQRISURWHLQVLQWKHLPPHGLDWHYLFLQLW\RIDWDUJHWPHPEUDQHSURWHLQ7KHVHPHWKRGVDUH