HOMER2 (NM 199330) Human Tagged ORF Clone – RC223154L4

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HOMER2 (NM 199330) Human Tagged ORF Clone – RC223154L4

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for RC223154L4 HOMER2 (NM_199330) Human Tagged ORF Clone Product data: Product Type: Expression Plasmids Product Name: HOMER2 (NM_199330) Human Tagged ORF Clone Tag: mGFP Symbol: HOMER2 Synonyms: ACPD; CPD; DFNA68; HOMER-2; VESL-2 Vector: pLenti-C-mGFP-P2A-Puro (PS100093) E. coli Selection: Chloramphenicol (34 ug/mL) Cell Selection: Puromycin ORF Nucleotide The ORF insert of this clone is exactly the same as(RC223154). Sequence: Restriction Sites: SgfI-MluI Cloning Scheme: ACCN: NM_199330 ORF Size: 1062 bp This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 HOMER2 (NM_199330) Human Tagged ORF Clone – RC223154L4 OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. RefSeq: NM_199330.1 RefSeq Size: 2005 bp RefSeq ORF: 1065 bp Locus ID: 9455 UniProt ID: Q9NSB8 Protein Families: Druggable Genome MW: 40.4 kDa Gene Summary: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011] This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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Mitotic Chromosome Binding Predicts Transcription Factor Properties in Interphase
bioRxiv preprint doi: https://doi.org/10.1101/404723; this version posted August 31, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Mitotic chromosome binding predicts transcription factor properties in interphase Authors: Mahé Raccaud1, Andrea B. Alber1,2, Elias T. Friman1,2, Harsha Agarwal3, Cédric Deluz1, Timo Kuhn3, J. Christof M. Gebhardt3 and David M. Suter1,4 Affiliations: 1Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland 2These authors contributed equally 3Institute of Biophysics, Ulm University, Albert-Einstein-Allee 11, Ulm 89081, Germany 4Lead contact Corresponding author: David M. Suter ([email protected]) Summary Mammalian transcription factors (TFs) differ broadly in their nuclear mobility and sequence- specific/non-specific DNA binding affinity. How these properties affect the ability of TFs to occupy their specific binding sites in the genome and modify the epigenetic landscape is unclear. Here we combined live cell quantitative measurements of mitotic chromosome binding (MCB) of 502 TFs, measurements of TF mobility by fluorescence recovery after photobleaching, single molecule imaging of DNA binding in live cells, and genome-wide mapping of TF binding and chromatin accessibility. MCB scaled with interphase properties such as association with DNA-rich compartments, mobility, as well as large differences in genome-wide specific site occupancy that correlated with TF impact on chromatin accessibility. As MCB is largely mediated by electrostatic, non-specific TF-DNA interactions, our data suggests that non-specific DNA binding of TFs enhances their search for specific sites and thereby their impact on the accessible chromatin landscape.
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