Current Approach to the Diagnosis and Emergency Department Management of Appendicitis in Children
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CME REVIEW ARTICLE Current Approach to the Diagnosis and Emergency Department Management of Appendicitis in Children Susan C. Lipsett, MD and Richard G. Bachur, MD of negative appendectomies.2 More recently, the negative appen- Abstract: Concerns about radiation exposure have led to a decrease in the dectomy rate in children approaches 4%, with higher rates in use of computed tomography in suspected appendicitis, with increased re- young children and female adolescents.3 liance on ultrasound. Children with suspected appendicitis should be risk Because of increasing recent concerns about radiation stratified using a combination of clinical signs and symptoms, white blood exposure in children, the rate of CTusage in the evaluation of ap- cell count, and ultrasound in order to guide further evaluation and manage- pendicitis has decreased significantly with a balancing increase ment. Magnetic resonance imaging is a promising imaging modality in ultrasound utilization. Reassuringly, this trend appears to have but remains costly. Ongoing research is evaluating the role of nonoper- had no adverse effect on the rate of ED revisits, appendiceal perfo- ative management in children with confirmed appendicitis. ration, or negative appendectomy rate.4 Recent progress in the Key Words: abdominal pain, appendicitis, clinical decision rule, evaluation of suspected appendicitis has focused on strategies diagnostic testing, surgery that integrate clinical scores, the white blood cell (WBC) count, – and ultrasound findings to risk-stratify children and facilitate (Pediatr Emer Care 2017;33: 198 205) management decisions. TARGET AUDIENCE EPIDEMIOLOGY This CME activity is intended for physicians who care for The incidence of acute appendicitis in the United States is 11 children with acute abdominal pain, including general pediatri- per 10,000 people per year, with a lifetime risk of appendicitis cians, emergency physicians, and surgeons. between 5% and 10%.5 Appendicitis is most common in children 10 to 19 years of age and has a slight male predominance.5 It LEARNING OBJECTIVES is also slightly more common in the summer months.5 Risk fac- After completion of this article, the reader should be able to: tors for perforation include longer duration of symptoms and younger age.6–8 1. Describe trends in diagnostic imaging for children with suspected appendicitis. DIFFERENTIAL DIAGNOSIS 2. Integrate clinical presentation, laboratory studies, and ultra- The differential diagnosis of a child presenting with suspected sound findings to assess a child’s risk of appendicitis and guide appendicitis is broad and is summarized in Figure 1. Special con- further workup. sideration should be given to the female adolescent, who is at risk 3. Provide appropriate initial management for children with con- of ectopic pregnancy and ovarian pathology, and to the very firmed appendicitis in the emergency department. young child, who is at increased risk of perforation. cute appendicitis remains a diagnostic challenge for pediatric HISTORY AND PHYSICAL EXAMINATION A acute care clinicians. In this article, we review the historical The first symptom of appendicitis in a child is usually a com- perspective and epidemiology of acute appendicitis in children. plaint of periumbilical or generalized abdominal pain. Classically, We will then outline a basic framework for the diagnostic ap- but not always, over the course of hours, the pain worsens and mi- proach to children with suspected appendicitis, which integrates grates toward the right lower quadrant (RLQ). Low-grade fever, clinical findings, laboratory studies, and imaging modalities. anorexia, nausea, and vomiting may be present, but the abdominal pain generally precedes these symptoms. The child may complain HISTORICAL PERSPECTIVE of pain with walking. The location of pain in appendicitis may Appendicitis was first described in 1886, with prompt surgi- vary, depending on the length and position of the appendix. Thus, cal management recommended as definitive treatment.1 Until the clinicians should not eliminate appendicitis from consideration in late 20th century, diagnosis was purely based on history and phys- children presenting with pain in the right upper quadrant, flank, ical examination, with an acceptable negative appendectomy rate groin, or suprapubic region. Similarly, the duration of the symp- of 20% to 25%.2 The increase in utilization of computed tomogra- toms will affect the intensity of the symptoms and signs, making phy (CT) over the last 2 decades led to a steady decrease in the rate the diagnosis quite difficult in the early stages. The physical examination should begin with a general as- sessment of the appearance and activity level of the child. An ac- Staff Physician (Lipsett) and Chief (Bachur), Division of Emergency Medicine, tive child who is walking easily around the room is less likely to Boston Children’s Hospital, Boston, MA. have appendicitis than the child who is laying quietly in bed resis- The authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no tant to movement. Key components of the examination include financial relationships with, or financial interest in, any commercial careful examination of the lung fields to evaluate for pneumonia organizations pertaining to this educational activity. and a genitourinary examination especially in males (testicular Reprints: Susan C. Lipsett, MD, Division of Emergency Medicine, Boston torsion, hernia) and amenorrheic pubescent girls (hematocolpos). Children’s Hospital, 300 Longwood Ave, Boston, MA 02115 (e‐mail: [email protected]). In sexually active girls, a bimanual examination may be indicated Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. to assess for cervical motion tenderness and adnexal tenderness or ISSN: 0749-5161 fullness. The abdominal examination should focus on the location 198 www.pec-online.com Pediatric Emergency Care • Volume 33, Number 3, March 2017 Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Pediatric Emergency Care • Volume 33, Number 3, March 2017 Diagnosis and ED Management of Appendicitis FIGURE 1. Differential diagnosis of children with suspected appendicitis. of maximal tenderness, with the RLQ being most suggestive of ap- appendicitis exhibited features such as RLQ tenderness, percus- pendicitis; many clinicians refer to the point of maximal tender- sive tenderness, and guarding.9 ness relative to McBurney point, the position one third of the distance medially along a line drawn from the anterior superior il- LABORATORY EVALUATION iac spine to the umbilicus. Examination of the abdomen should also attempt to identify signs of peritonitis such as rebound tender- A complete blood count with differential should be obtained ness, guarding, and referred pain to the RLQ from palpation of the for all children in whom appendicitis is suspected, as the WBC count and absolute neutrophil count (ANC) have been shown to left lower abdomen (Rovsing sign). Unwillingness to jump or 10–12 cough is also suggestive of peritoneal irritation. Bowel sounds will be useful in predicting risk of appendicitis. be hypoactive in advanced appendicitis. Right-lateral-wall tender- Other laboratory tests, although not generally useful in ness on rectal examination can also be suggestive of appendicitis, predicting risk of appendicitis, may help to exclude alternate eti- but rectal examinations have become less routine in young chil- ologies. A urine pregnancy test should be obtained for all dren. Less specific findings in patients with an inflamed retrocecal postpubertal females. A normal urinalysis rules out new-onset di- appendix include an obturator sign (pain with internal rotation of abetes and decreases the likelihood of urinary tract infection or the right hip) and psoas sign (pain with extension of the hip or flex- nephrolithiasis. It is important to remember that many children “ ” ion of the hip against resistance). with appendicitis will have sympathetic, or sterile, pyuria with Table 1 summarizes the frequency of specific signs and a few WBCs in the urine due to ureteral or bladder irritation. If symptoms in children with suspected appendicitis. It should be the abdominal pain is more prominent in the right upper quadrant noted that many children present with atypical features; for exam- or if there is persistent vomiting, transaminases, serum bilirubin, ple, in the cited study, 40% of children with confirmed appendici- and lipase may be indicated to evaluate for hepatobiliary pathology tis did not have anorexia, 30% did not have maximal tenderness in or pancreatitis. Serum electrolytes should be obtained in ill- the RLQ, and 20% had pain duration of more than 48 hours. Al- appearing or very dehydrated patients. C-reactive protein, al- though possibly associated with increased risk of perforation and most 20% of children with confirmed appendicitis had report of 13–15 diarrhea. In addition, a substantial number of children without complicated clinical course, does not discriminate appendici- tis from other causes of abdominal pain. TABLE 1. Frequency of Signs and Symptoms in Children With CLINICAL SCORES Suspected Appendicitis9 Although history, physical examination, and laboratory find- ings are helpful in the evaluation of a patient with suspected appen- Finding Appendicitis, % No Appendicitis, % dicitis, no single finding sufficiently predicts a child’s risk. Thus, several clinical