United States Patent (19) 11 Patent Number: 6,114,143 Eda Et Al
USOO611.4143A United States Patent (19) 11 Patent Number: 6,114,143 Eda et al. (45) Date of Patent: *Sep. 5, 2000 54). ANTI-HIV MONOCLONAL ANTIBODY 90O3984 4/1990 WIPO. 9015078 12/1990 WIPO. 75 Inventors: Yasuyuki Eda; Hiroaki Maeda; 9304090 3/1993 WIPO. Keiichi Makizumi, Kouichi Shiosaki, all of Kumamoto; Kiyoshi Osatomi, OTHER PUBLICATIONS Nagasaki, Kazuhiko Kimachi, Kumamoto; Hirofumi Higuchi, Kumamoto; Sachio Tokiyoshi, Matsushita, et al. : Characterization of a Kumamoto, all of Japan mouse/human . : AIDS Res. and Hum. Retro. v. 8, No. 6: pp. 1107–1115, 1992. 73 Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Ohno, et al. : A broadly neutalizing monoclonal . Proc. Institute, Kumamoto, Japan Natl. Acad. Sci. : V. 88: pp. 10726–10729, 1991. * Notice: This patent issued on a continued pros Scott, et al. : Human monoclonal antibody that ecution application filed under 37 CFR recognizes ... : Proc. Natl. Acad. Sci. : V. 8: pp. 8597-8601, 1.53(d), and is subject to the twenty year 1990. patent term provisions of 35 U.S.C. 154(a)(2). Primary Examiner Jeffrey Stucker 21 Appl. No.: 08/513,968 ASSistant Examiner Brett Nelson 22 PCT Filed: Mar. 9, 1994 Attorney, Agent, or Firm-Browdy and Neimark 86 PCT No.: PCT/JP94/00371 57 ABSTRACT S371 Date: Sep. 11, 1995 A monoclonal antibody useful for clinical application which S 102(e) Date: Sep. 11, 1995 recognizes the conserved region of V3-PND region of 87 PCT Pub. No.: WO9420632 glycoprotein antigen having a molecular weight of about PCT Pub. Date: Sep. 15, 1994 1.2x10 daltons (gp120) on a coating membrane of human 30 Foreign Application Priority Data immunodeficiency virus (HIV) and which has an ability to neutralize a broad range of various HIV variants, or a Mar.
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