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Abstract Book Abstract book WELCOME Dear participants, welcome to the 2010 International PhD Students Cancer Conference here at the IFOM-IEO Campus in Milan! We have tried to organize this conference at our best, hoping it will be an excellent opportunity to discuss about science, to meet new and interesting people and to broad our knowledge. We are very glad to host such an international meeting, with students coming from institutes all across Europe; moreover, this year we are very pleased to host students from the National Centre for Biological Sciences, Bangalore, India. We do hope you will find this conference really exciting and that you will have a great time here in Milan! Thank you all for coming!! The Organizers FOR ORGANIZATION REASONS, YOU ARE KINDLY REQUESTED TO ALWAYS WEAR/SHOW THE CONFERENCE BADGE! THANK YOU VERY MUCH FOR YOUR COLLABORATION! Federica Castellucci: [email protected] Francesca Milanesi: [email protected] Gianmaria Sarra Ferraris: [email protected] Chiara Segrè: [email protected] Gianluca Varetti: [email protected] International PhD Student Cancer Conference International PhD Student Cancer Conference 19th – 21st May 2010 IFOM-IEO Campus, Milan, Italy This is the fourth annual conference that is hosted and organized by students from the European School of Molecular Medicine (SEMM). The Conference will cover many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees will present their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe. International PhD Student Cancer Conference ORGANIZATION SEMM PhD student conference organizing committee Federica Castellucci Francesca Milanesi Gian Maria Sarra Ferraris Chiara Segré Gianluca Varetti Supported by: Francesco Blasi (SEMM PhD Program Coordinator) Deborah Agostini (web and graphic design) Sabrina Frata (SEMM events coordinator) International PhD Student Cancer Conference PARTICIPATING INSTITUTES CORE PARTICIPANTING INSTITUTES European School of Molecular Medicine (SEMM) – IFOM-IEO Campus, Milan Cancer Research UK Institutes: ▪ Beatson Institute for Cancer Research (BICR), Glasgow ▪ Cambridge Research Institute (CRI), Cambridge, UK ▪ MRC Gray Institute of Radiation Biology (GIROB), Oxford ▪ London Research Institute (LRI), London ▪ Paterson Institute for Cancer Research (PICR), Manchester The Netherlands Cancer Institute (NKI), Amsterdam INVITED INSTITUTES European Molecular Biology Labs (EMBL), Heidelberg & European Bioinformatics Institute (EMBL EBI), Hinxton German Cancer Research Centre (DKFZ), Heidelberg Medical Research Council (MRC) National Institute for Medical Research (NIMR), London National Centre for Biological Sciences (NCBS), Bangalore Spanish National Cancer Centre (CNIO), Madrid Swiss Institute for Experimental Cancer Research (ISREC-EPFL) and Department of Biochemistry of the Lausanne University (DB-UNIL), Lausanne International PhD Student Cancer Conference SPONSORS A very “Special Thanks” to our kind Sponsors International PhD Student Cancer Conference TABLE OF CONTENTS Scientific Program May 19, 2010 – Keynote lecture, lecture, oral presentations and poster session I May 20, 2010 – Lectures, poster session II and oral presentations May 21, 2010 – Keynote lecture and oral presentations Keynote Speakers Special Sessions Authors’ Index Important Addresses Know before you go - Milan International PhD Student Cancer Conference Scientific Program SCIENTIFIC PROGRAM MAY 19, 2010 h. 12.00/14.00 Registration, poster session I set up, sandwiches and hotel check in h. 14.00/14.15 Opening remarks Prof. Pier Giuseppe Pelicci (IEO, Milan) h. 14.15/14.45 Special session I Dr. Giuseppe Testa (IEO, Milan) Priming the epigenome in differentiation and cancer SESSION I: Cellular Differentiation and development Chairperson: Guillermo Menendez (LRI, London) h. 14.45/15.05 Matteo Marzi (IFOM, Milan) E1A regulated micrornas couple differentiation and cell cycle exit h. 15.05/15.25 Joerg Hoeck (LRI, London) Fbw7 controls neural stem cell differentiation and progenitor apoptosis by antagonising Notch and JNK/c-Jun signalling h. 15.25/15.45 Shefali Talwar (NCBS, Bangalore) Spatiotemporal analysis of higher order chromatin assembly during cellular differentiation h. 15.45/16.05 Feng Wang (CRI, Cambridge) The Xenopus orthologue of TGFBI is required for early embryogenesis through regulation of canonical Wnt signalling h. 16.05/16.35 Coffee break International PhD Student Cancer Conference 15 Scientific Program h. 16.35/17.45 Poster session I h. 17.45/18.30 Keynote lecture I: Dr. Peter Friedl (Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen; The Netherlands) Plasticity of cancer invasion and implications for therapy h. 18.30/18.45 Set up poster session II (removal posters session I) h. 18.45/21.00 “Pizza party” at the IFOM-IEO Campus bar h. 21.00 Transfer by private bus from IFOM-IEO Campus to Ripamonti apartment hotel International PhD Student Cancer Conference 16 Scientific Program MAY 20, 2010 h. 8.30 transfer by private bus from Ripamonti apartment hotel to IFOM-IEO Campus SESSION II: Cell migration & Immunology Chairperson: Meiling Gao (BICR, Glasgow) SESSION IIa: Cell migration h. 9.30-9.50 Anne Lempens (BICR, Glasgow) ERK2 but not ERK1 contributes to invasive migration of tumour cells h. 9.50-10.10 Roheet Bantval Rao (CRI, Cambridge) Huntingtin interacting protein 1 (HIP1) induces Epithelial-to-Mesenchymal Transition (EMT) in prostate cancer cells h. 10.10-10.30 Melda Tozluoglu (LRI, London) Multiscale Modelling of Cancer Cell Motility SESSION IIb: Immunology h. 10.30-10.50 Tim Schnyder (LRI, London) Spatially resolved negative regulation of B cell receptor signalling h. 10.50-11.10 Eva Schlecker (DKFZ, Heidelberg) Control of anti-tumor immune responses by myeloid-derived suppressor cells h. 11.10-11.30 Coffee break h. 11.30-12.00 Special session II: Prof. Pier Paolo Di Fiore (IFOM, Milan) Endocytosis and recycling at the crossroad of signaling, attenuation, execution of polarized functions and cell fate determination h. 12.00-12.30 Participating Institute presentations International PhD Student Cancer Conference 17 Scientific Program h. 12.30-13.30 Lunch at the IFOM-IEO Campus bar SESSION III: Modeling and large scale analysis in cancer research Chairperson: Willem-Jan Keune (PICR, Manchester) h. 13.30-13.50 Christiaan Klijn (NKI, Amsterdam) Finding co-occurrence and mutual exclusiveness of DNA copy number changes h. 13.50-14.10 Xiaofan Li (LRI, London) How does a protein find its mates in a crowded cell? h. 14.10-14.30 Gilda Nappo (IFOM, Milan) A SILAC Proteomic Approach Identified Novel Candidate Players in the Non-Clathrin Endocytic Pathway of the EGFR h. 14.30-14.50 Rebecca Burrell (LRI, London) Using Integrative Genomics To Investigate Mechanisms of Chromosomal Instability h. 14.50-16.00 Poster session II and soft drinks SESSION IV: Genome instability and cancer Chairperson: Magdalena Zajac (CNIO, Madrid) h. 16.00-16.20 Marieke Peuscher (NKI, Amsterdam) An shRNA screen to identify novel factors involved in telomere damage induced genome instability h. 16.20-16.40 Tanja van Harn (NKI, Amsterdam) Loss of RB proteins causes genomic instability in the absence of mitogenic signaling International PhD Student Cancer Conference 18 Scientific Program h. 16.40-17.00 Dhaval Varshney (BICR, Glasgow) Silent assassins: DNA methylation does not inhibit SINE transcription, but suppressed their recombination h. 17.00-17.20 Sietske Bakker (NKI, Amsterdam) Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M h. 17.20-18.05 Special session III: Bioethics round table Silvia Camporesi & Alessandro Blasimme (IFOM-IEO, Milan) World-wide human embryonic stem cell policies: who decides and on what grounds? h. 18.10 Transfer to Ripamonti apartment hotel by private bus h. 20.00 Transfer from Ripamonti apartment hotel to the Skyline Restaurant by private bus h. 20.30: Social Dinner at Skyline restaurant h 24.00 Transfer by private bus from the Skyline restaurant to Ripamonti apartment hotel International PhD Student Cancer Conference 19 Scientific Program MAY 21, 2010 h. 9.30 Transfer by private bus from Ripamonti apartment hotel to IFOM-IEO Campus SESSION V: Signal transduction & Cancer genetics and drug resistance Chairperson: Gordana Halec (DKFZ, Heidelberg) SESSION Va: Signal transduction h. 10.00-10.20 Andrea Longatti (LRI, London) Rab-GTPases and Rab-GAPs Involved in Autophagy h. 10.20-10.40 Francesca Montani (IEO, Milan) The mitotic exit oscillator at work h. 10.40-11.00 Lakshmi Revathi Perumalsamy (NCBS, Bangalore) A non-canonical Notch cascade converges on mitochondria for the regulation of cell survival SESSION Vb: Cancer genetics and drug resistance h. 11.00-11.20 Rinske Drost (NKI, Amsterdam) The impact of defined Brca1 mutations on tumor development, drug response and acquired resistance h. 11.20-11.40 Charlotte Ng (CRI, Cambridge) Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma h. 11.40-12.00 Conference photo h. 12.00-12.45 Tour of the IFOM-IEO-CAMPUS h. 12.45-13.45 Lunch at the IFOM-IEO Campus bar International PhD Student Cancer Conference 20 Scientific Program h. 13.45-14.30 Keynote lecture II : Prof. Andreas Trumpp (Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and Heidelberg Institute
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