The Nextprot Knowledgebase in 2020
D328–D334 Nucleic Acids Research, 2020, Vol. 48, Database issue Published online 14 November 2019 doi: 10.1093/nar/gkz995 The neXtProt knowledgebase in 2020: data, tools and usability improvements Monique Zahn-Zabal1, Pierre-Andre´ Michel1, Alain Gateau1,Fred´ eric´ Nikitin1, Mathieu Schaeffer1,2, Estelle Audot1, Pascale Gaudet 1, Paula D. Duek1, Daniel Teixeira1, Valentine Rech de Laval1,2,3, Kasun Samarasinghe1,2,AmosBairoch1,2 and Lydie Lane1,2,* 1CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 2Department of microbiology and molecular medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland and 3Haute ecole´ specialis´ ee´ de Suisse occidentale, Haute Ecole de Gestion de Geneve,` Carouge, Switzerland Received September 11, 2019; Revised October 10, 2019; Editorial Decision October 11, 2019; Accepted October 18, 2019 ABSTRACT post-translational modifications (PTMs), as well as peptide identified in mass spectrometry experiments and epitopes The neXtProt knowledgebase (https://www.nextprot. recognized by antibodies have been integrated from a num- org) is an integrative resource providing both data ber of resources. By doing so, neXtProt extends the contents on human protein and the tools to explore these. of UniProtKB/Swiss-Prot (2) to provide a more compre- In order to provide comprehensive and up-to-date hensive data set. data, we evaluate and add new data sets. We describe However, data alone is not sufficient for scientists to the incorporation of three new data sets that provide comprehend complex information rapidly. For this reason, expression, function, protein-protein binary interac- neXtProt organizes the information concerning an entry in tion, post-translational modifications (PTM) and vari- several views, with interactive viewers that allow the user to ant information.
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