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Abstract Book 45th European Muscle Conference Muscle Research in Health and Disease ABSTRACT BOOK September 2nd-6th, 2016 Montpellier, France tH EUROPEAN MUSCLE 45 CONFERENCE www.emc2016-montpellier.com Patronage 2 45th European Muscle Conference in Montpellier, France WELCOME to EMC 2016 in Montpellier, FRanCE Dear Colleagues of the European Muscle Research Society, It is with great pleasure that we welcome you including a record-breaking number of 224 to the South of France and Montpellier for the abstracts organized into 15 sessions, 56 oral 45th European Muscle Conference. In each of presentations and 18 lectures delivered by invited the last decades, we have been fortunate to host speakers. As in previous years, the meeting will the European Muscle Conference in our city give the opportunity to young scientists to present (1986-225 participants, 1996-240 participants, their work in a convivial environment. Winners 2003-340 participants), each time in a new of the traditional Young Investigator sessions environment. This year the conference will be will be announced at the Awards Ceremony held in the old Faculties of Law and Medicine, on Tuesday. We have proposed a session the in the historical center of Montpellier. The first afternoon of the meeting for the “Muscle Faculty of Medicine was officially created by researchers of Tomorrow”, where talks will focus Pope Nicolas IV in 1289, resulting in it being on scientific integrity and career development. the oldest, still practicing faculty in the world. The first teaching class of anatomy was In order to attract future scientists to the muscle created at Montpellier University in 1220. The field, with the help of Montpellier University, we university was very attractive to students from have welcomed Master degree students to our all over Europe due to the incorporation of the sessions, for their immersion into the prominent knowledge of Arabic and Jewish humanists. scientific muscle research environment of Notably, Nostradamus and François Rabelais the EMC. We have strong participation of taught at the University. the French muscle research community in Your presence at the EMC continues the attendance, contributing to nearly a quarter of historical attractiveness and world-famous the abstracts. scientific repute of the University. The conference will cover all aspects of muscle Please do not forget to stroll through the research from basic to applied sciences. It offers historical center of Montpellier and enjoy the an ideal forum for scientific exchange between relaxed way of life of the city. The gala Dinner specialists from different scientific disciplines on Monday the 5th will allow you to appreciate and among junior and senior scientists. the proximity of the beach and the beautiful Up to 350 participants are expected from 34 Mediterranean sea. different countries, including 16 non-European countries, to enjoy great science and the beauty Welcome to Montpellier, and pleasures of the historical city of Montpellier Welcome to the European and the wonderful Languedoc Region. Muscle Conference 2016 We are honored to receive this year’s EMC On behalf of the organizing committee Lecturer, Prof Andrew Marks from Columbia Olivier Cazorla and Stefan Matecki University, New York. Prof Marks will give the Opening Lecture on Friday during The Inaugural session at the Faculty of Law. Prof Marks will Local Host Committee present on his contribution to research on the Jérémy Fauconnier, Ryanodine receptor. Alain Lacampagne, Jacques Mercier State-of-the-art science will be presented during four days of oral and poster abstract sessions, Sponsors A special thank you to: Professor Jean Emile Morel for the donation of his book “Molecular and Physiological Mechanisms of Muscle Contraction”. You can consult it at the Welcome Desk of the Congress. Contents Program ............................................................................................................................... 06 Opening Lecture ...................................................................................................................... 15 Session 01: Muscle plasticity and Chronic disease .................................................... 16 Session 02: Molecular motor and Contractile function ........................................... 28 Session 03: Mitochondrial Dynamics ............................................................................. 36 Session 04: Excitation contraction coupling in cardiac muscle ............................ 41 Session 05: Muscle development and aging ............................................................... 46 Session 06: Muscle cytoskeleton ...................................................................................... 56 Session 07: Smooth Muscle and vascular Function ................................................... 65 Session 08: Epigenetics of muscle regeneration ........................................................ 69 Session 09: Neuro-muscular disease and therapeutic approach ........................ 75 Session 10: Molecular motor and Contractile structure ........................................... 89 Session 11: Mechanotransduction (VIDD, Shear stress, Starling’s law) ............... 97 Session 12: Bio energetics and ROS ................................................................................. 104 Session 13: Excitation-contraction coupling in skeletal muscle ........................... 118 Session 14: Cardiomyopathy and Heart failure ........................................................... 129 Author Index ............................................................................................................................. 140 5 45th European Muscle Conference in Montpellier, France Faculty of Medicine See Map in Faculty of Law and Political Science this guide PROgRAM Departure Gala Dinner tH EUROPEAN MUSCLE 45 CONFERENCE Faculty of Law and H C A Political Science Hall Cloister Auditorium FRIDaY, 2 SEPTEMBER 2016 - Faculty of Medicine and Faculty of Law and Political Science 14h00 Young Investigator session - Faculty of Medicine 14h00 Welcome & Introduction 14h00 How to design a research proposal/protocol. Luc Bertrand (Belgium) 14h45 How to choose the good statistics. to be announced / Denis Angoulvant (France) 15h30 Coffee break - ‐Visit of exhibitors - ‐Posters 15h45 Young Investigator session - Faculty of Medicine 15h45 How to write a scientific manuscript ? to be announced / Mathias Gautel (UK) 16h30 Scientific integrity against the publication pressure. Pieter de Tombe (USA) 17h15 End of the Young Investigator session 19h00 Key note lecture - Andy Marks - Faculty of Law and Political Science A 20h30/ Welcome reception - Faculty of Medicine 22h00 SATURDaY, 3 SEPTEMBER 2016 - Faculty of Law and Political Science 08h15 Welcome Coffee C 08h45 Welcome & Introduction 09h00 Session 01 - Muscle plasticity and chronic disease A Chairperson: Adams Volker (Germany) & Xavier Bigard (France) 09h00 Introduction: Impact of exercise training on skeletal muscle in heart failure: A molecular point of view. Adams Volker (Germany) 09h25 Involvement of the ubiquitin/proteasome signalling pathway in the oxidative stress-induced atrophy of cultured Chronic Obstructive Pulmonary Disease myotubes. Pascal Pomiés (France) 09h40 Morphological indices and markers of signaling pathways in skeletal muscle of patients with alcoholic myopathy Svetlana Belova (Russia) 09h55 Physiopathological characterization of the role of MCUb in skeletal muscle regeneration. Simona Feno (Italy) 10h10 Resveratrol enables myotube survival under nutrient stress. Hannah Dugdale (UK) 10h30 Coffee break - ‐Visit of exhibitors - ‐Posters C 11h00 Session 02 - Molecular motor and Contractile function (acto-myosin) A Chairperson: Vicenzo Lombardi (Italy) & Robin Candau (France) 11h00 Introduction: Myosin II-based native and synthetic machines - Vicenzo Lombardi (Italy) 11h25 Myosin-induced structural changes in actin filaments during actomyosin based motion generation at different concentrations of MgATP. Alf Mansson (Sweden) 11h40 Age-dependent development of Cardiac Dysfunction in Transgenic Mice Carrying Actin E99K Mutation. Masataka Kawai (USA) 11h55 Functional properties of αβ-tropomyosin with mutations in the α-chain are different from those of αα-tropomyosin with mutations in both α-chains. Daniil Shchepkin (Russia) 12h10 Muscle performance in response to resistance training is mainly controlled by an increase in myosin ATPase activity independent of the MHC. Antony Philippe (France) 12h30 Lunch C 13h00 Poster session (Sessions 01, 02, 03, 04) End 14h00 C 14h15 Session 03 - Mitochondrial dynamics A Chairperson: Martin Picard (USA) & Jeremy Fauconnier (France) 14h15 Introduction: Mitochondrial morphology-function dynamics and signaling in skeletal muscle. Martin Picard (USA) 14h40 HACD1 and very long chain fatty acids: new structural and functional actors in muscle growth and metabolism. Laurent Tiret (France) 14h55 Mitochondrial morphology changes in skeletal muscle fibers correlate with sarcopenia symptoms in aged-mice. Andrea Del Campo (Chile) 15h10 Serine/Threonine Protein Kinase 25 (STK25) Regulates Ectopic Lipid Accumulation, Mitochondrial Function and Insulin Sensitivity in Skeletal Muscle. Margit Mahlapuu (Sweden) 15h25 Mitochondrial function in diaphragm muscle fibers of mechanically ventilated critically ill patients. Marloes Van Den Berg (Netherlands) 15h45 Coffee break - ‐Visit of exhibitors - ‐Posters C 16h15 Session 04 - Excitation contraction coupling
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