INDEX

Abstracts, New Haven meeting, 1 Arterenol, derivatives of, as bronchodi- Acetate, iodo-, action of, on auricle, 166 lators, 304 Acetyicholine, see Quaternary ammonium effect of, on hepatic blood flow, 398 compounds inhibiting effect of, on histamine induced Acetylmethadols, and acetylisomethadols, gastric secretion, 447 as analgesic agents, 135, fate of, 260 see Levarterenol Adrenergic blockade, effect on, of denerva- vascular responses to, effect on, of de- tion of vascular areas, 93 nervation, 93 Adrenergic blocking drug, effect of Ilidar Atropine, comparison of, to Centrine, 55 on renal function, 277 Aureomycin, absorption of, enhancement series of B-chloroethylamines, 463 by citric acid, 327 Ahlquist, R. P., Taylor, J. P., Rawson, effect of, on formation of adaptive enzyme C. W., Jr., and Sydow, V. L. Compara- in Pseudomonas, 115 tive effects of epinephrine and levar- Autonomic blocking action, of piperazines, terenol in the intact anesthetized dog, 157 352 Axeirod, J. Studies on sympathomimetic Aminopentamide, actions of, 55 amines. II. Biotransformation and Amphetamine, p-hydroxy, transformation physiological disposition of d-amphet- and disposition of, 315 amine, d-p-hydroxyamphetamine and transformation and disposition of, 315 d-methamphetamine, 315 Analgesic agents, see Methadols, Isometh- adols Bain, J. A., see Brody, T. M., 148 Andromedotoxin, actions of, 415 Barbiturates, effect of, on oxidative phos- Anectine, see Succinyldicholine phorylation, 148 Anesthetics, general, xenon, concentration ejaculation produced by, 271 in tissues after inhalation, 458 see Pentobarbital general, see Xenon, Nitrous Oxide Beck, R., see Robinson, E. M., 385 Antibiotics, effect of, on formation of adap- Belford, J., see Woske, H., 215 tive enzyme in Pseudomonas, 115 Bender, C. W., see McNamara, B. P., 232 see Aureomycin Benforado, J. M., and Witt, P. N. Influence Anticholinesterases, mechanism of action of of heart rate upon the lethal dose of DFP and TEPP, 385 veratridine in the heart-lung prepara- see DFP, TEPP tion of the dog, 334 Anticoagulants, phenylindanedione, dispo- Bergner, A. D., see McNamara, B. P., 232 sition of, 451 Bernheim, F. Effect of certain antibiotics Anticonvulsant, properties of 5,5-diphenyl- on the formation of an adaptive enzyme

tetrahydroglyoxaline - 4 - one, SKF in a strain of Pseudomonas aeruginosa, 2599, 403 115 diphenyihydantoin, 403 Blocking action, of piperazines, 157 Antihistamines, coronary dilator action of, Borison, H. L., see Brand, E. D., 86 300 Boyd, E. M., and Millar, I. E. Lack of effect piperazines as, 157 of codeine phosphate and dihydro- Antispasmodic compounds, and metho salts, codeinone bitartrate upon the volume pharmacology of, 282 output, specific gravity, relative vis- Apomorphine, emetic action antagonized by cosity and chloride content of respira- chiorpromazine, 86 tory tract fluid, 443 Arduini, A., and Arduini, M. G. Effect of Brain stem activity, effect on, of various drugs and metabolic alterations on drugs, 76 brain stem arousal mechanism, 76 Brand, E. D., Harris, T. D., Borison, H. L., Arduini, M. G., see Arduini, A., 76 and Goodman, L. S. Anti-emetic activ-

471 472 INDEX

ity of 10-(-y-dimethylaminopropyl)-2- Cholinergic drug, tetrakis-(dimethylamino- chlorophenothiazine (Chiorpromazine) methyl) methane tetramethobromide, in dog and cat, 86 127 Brody, T. M., and Bain, J. A. Barbiturates Cholinesterase, inhibition of, and DFP and and oxidative-phosphorylation, 148 TEPP, 385 Bronchodilators, arterenol derivatives as, Citric acid, enhancement by, of absorption 304 of aureomycin, 327 Bronchosecretion, effect on, of codeine and Code, C. F., see Forrest, A. P. M.,447 dihydrocodeinone, 443 Codeine, effect of, on bronchial secretions, Brooks, C. McC., see Woske, H., 215 443 Brown, B. B., and Werner, H. W. Pharma- Cook, D. L., Lawler, C. A., and Green, cologic studies on a new central stimu- D. M. Studies on the effect of hydro- lant, a-(2-piperidyl)benzhydrol hydro- choleretic agents on hepatic excretory chloride (Dol), 180 mechanisms, 309 Brown, W. C., see Goodman, L. S., 403 Copper sulfate, emetic action antagonized Butler, T. C., and Waddell, W. J. Pharmaco- by Chlorpromazine, 86 logical comparison of the optical Coronary arteries, action on, as dilators, of isomers of 5-ethyl-5-phenyl hydantoin antihistamines, 300 (Nirvanol) and of 3-methyl-5-ethyl-5- Cunningham, R. W., see Gray, W. D., 327 phenyl hydantoin (Mesantoin), 120 Curare, see d-Tubocurarine -, and Waddell, W. J. Role of the liver in Cyanide, sodium, effect of, on brain stem the demethylation of N-methyl deriva- arousal mechanism, 76 tives of hydantoin and 2,4-oxazoli- dinedione, 241 de Beer, E. J., see Norton, 5., 392 Demethylation, role of liver in, in deriva- tives of hydantoin and 2,4-oxazoli- Calhoon, D. M., see Rennick, B. R., 309 dinedione, 241 Cardiac pharmacology, action of iodoace- DFP, mechanism of action of, 232, 385 tate on rabbit auricle, 166 Dibenzyline, actions of, 463 cardiovascular actions of andromedo- Dickison, H. L., see Hoekstra, J. B., 55 toxin, 415 Digitalization, effect of, on excitability and effect of induced failure and digitaliza- rhythmicity of the dog’s heart, 215 tion on excitability and rhythmicity of Digitoxin, synthesis and isolation of C’ the dog’s heart, 215 labeled, 244 influence of heart rate on lethal dose of Dihydrocodeinone, effect of, on bronchial veratridine in heart-lung, 334 secretions, 443 relation of sugar moieties to action of Dilantin, see Diphenylhydantoin cardiac glycosides on embryonic chick Dinitrophenol, effect of, on oxidative phos- heart, 411 phorylation, comparison with barbitu- see also Coronary arteries rates, 148 see Serpasil Dioxolanes, as muscle relaxants, 251 Cavallito, C. J., see Lands, A. M., 369 Diphenylhydantoin, anticonvulsant po- Central stimulant, actions of a new, 180 tency and toxicity of, 403

Centrine, activity of, 55 5,5 - Diphenyl - tetrahydroglyoxaline - 4 - Chenoweth, M. B., see Hendershot, L. C., one, anticonvulsant potency and toxic- 344 ity of, 403 Chioramphenicol, effect of, on formation of Dragstedt, C. A., see Keyl, A. C., 411 adaptive enzyme in Pseudomonas, 115 Dresel, P. E., see Moran, N. C., 415 -Chloroethylamines, series of, 463 Chiorpromazine, as anti-emetic, 86 Edberg, L. J., see Robinson, E. M., 385 Chiortetracycline, see Aureomycin Eddy, N. B., see Leimbach, D. G., 135 Cholinergic compounds, evaluation of fac- Ejaculation, drug-produced, enhancement tors in ammonium compounds favorable by SKF No. 525A, 271 for Ach-like action, 369 Elliott, H. W., see Miller, J. W., 106 INDEX 473

Emesis, produced by morphine, ergot, vera- Glycosides, cardiac, relation of glucose to trum, copper sulfate, lanatoside-C, action on embryonic chick heart, 411 antagonism by Chlorpromazine, 86 cardiac, see Digitoxin Epinephrine, comparison with levarterenol Goodman, L. S., Swinyard, E. A., Brown, in intact anesthetized dog, 352 W. C., and Schiffman, D. 0. Anticon- inhibiting effect of, on histamine induced vulsant properties of 5,5-diphenyl- gastric secretion, 447 tetrahydroglyoxaline-4-one (SKF No. vascular responses to, effect on, of de- 2599), 403 nervation, 93 see Brand, E. D., 86 Ergot, emetic action antagonized by Chlor- Goodsell, J. S., Toman, J. E. P., Everett, promazine, 86 G. M., and Richards, R. K. Search for Ether, effect of, on brain stem arousal more effective muscle relaxants among mechanism, 76 the glycerol ethers and dioxolanes, 251 Everett, C. M., see Goodsell, J. S., 251 Gray, W. D., Hill, R. T., Winne, R., and Cunningham, R. W. Enhancement of chlortetracycline absorption by citric Farah, A., and Koda, F. Influence of plasma acid, 327 electrolyte concentration on mercurial Green, D. M., see Cook, D. L., 293 diuresis in the dog, 361 Green, H. D., see Griffin, P. P., 93 see Gardner, E. A., 166 Griffin, P. P., Green, H. D., Youmans, Fastier, F. N., see Woske, H., 215 P. L., and Johnson, H. D. Effect of Fatty acids, antagonism to fluoroacids, 344 acute and chronic denervation of the Featherstone, R. M., see Levy, L., 221 hind leg of the dog on the blood flow see Pittinger, C. B., 458 responses in the vascular beds of skin Fellows, E. J., McLean, R. A., Macko, E., and muscle to adrenergic drugs, and to Kerwin, J. F., Hall, G. C., Milnes, F. J., adrenergic blockade, 93 Witt, I. H., and Ullyot, G. E. Oral and Gross, E. G., see Pittinger, C. B., 458 intravenous adrenolytic activity of a number of N-benzyl-N-phenoxyethyl Hall, C. C., see Fellows, E. J., 463 and N-benzyl-N-phenoxyisopropyl-$- Handford, S. W., see Smythe, C. McC., 398 chloroethylamines, 463 Handley, C. A., and Moyer, J. H. Effect of a Fluoroacetate, antagonism by fatty acids, dibenzazepine derivative (Ilidar) on 344 renal function, 277 Fluorobutyrate, antagonism by fatty acids, see Seibert, R. A., 304 344 Harris, T. D., see Brand, E. D., 86 Fluorohexanoate, antagonism by fatty Hendershot, L. C., and Chenoweth, M. B. acids, 344 Antagonism of three homologous mono- Forrest, A. P. M., and Code, C. F. Inhibit- fluorinated fatty acids by several fatty ing effect of epinephrine and norepi- acids, 344 nephrine on secretion induced by hist- Hepatic, see Liver amine in separated pouches in dogs, 447 Hiatt, E. P., see Nungesser, W. C., 68 Fructose, effect of, on ketone bodies, 226 Hill, R. T., see Gray, W. D., 327 Histamine, as secretagogue, inhibition by Gandia, H., see Rennick, B. R., 309 epinephrine and arterenol, 447 Ganglionic blockade, by piperazines, 157 Hoekstra, J. B., Tisch, D. E., Rakieten, N., Gardner, E. A., Wilson, M., and Farah, A. and Dickison, H. L. Pharmacological Action of iodoacetate on the isolated activity of Centrine, 55 rabbit auricle, 166 Hydantoin, demethylation of N-methyl de- Geiling, E. M. K., see Okita, G. T., 244 rivatives of, 241 Gilmore, J. P., see Smythe, C. McC., 398 see Mesantoin, Nirvanol Glucose, relation of, to activity of cardiac glycosides on embryonic chick heart, Ilidar, adrenergic blockade by, effect on, 411 of denervation, 93 Glycerol ethers, as muscle relaxants, 251 effect of, on renal function, 277 474 INDEX

Insulin, effect of, on brain stem arousal gation of the pharmacological actions mechanism, 76 of three potent antispasmodic com- lodoacetate, action of, on rabbit auricle, 166 pounds and their corresponding metho- Isomethadols, acetyl-, as analgesic agents, salts, 282 135 Macko, E., see Fellows, E. J., 463 Johnson, H. D., see Griffin, P. P., 93 McLean, R. A., see Fellows, E. J., 463 McNamara, B. P., Murtha, E. F., Bergner, Kalow, W. Influence of pH on the ionization A. D., Robinson, E. M., Bender, C. W., and biological activity of d-tubocura- and Wills, J. H. Studies on the mech- rine, 433 anism of action of DFP and TEPP, 232 Kelsey, F. E., see Okita, G. T., 244 see Robinson, E. M., 385 Kensler, C. J., Langemann, H., and Zirkle, Mephenesin, comparison of, with several C. L. Cholinergic activity of tetrakis- glycerol ethers and dioxolanes, 251 (dimethylaminomethyl) methane tetra- Mercurial diuretics, influence of plasma methobromide, 127 electrolyte concentration on action of, Kerwin, J. F., see Fellows, E. J., 463 361 Ketone bodies, effect on, of fructose, 226 Mersalyl, action of, influence of plasma elec- Keyl, A. C., and Dragstedt, C. A. Relation- trolyte concentration on, 361 ship of the sugar moieties of the cardiac Mesantoin, optical isomers of, anesthetic glycosides to their toxicity on the in- activity, rate of demethylation, 120 tact embryonic chick heart, 411 Methadol, alpha-acetyl-, fate of optical Kidney, see Renal function isomers of, 260 Koda, F., see Farah, A., 361 Methadols, acetyl-, as analgesic agents, 135 Methadone, in vitro studies on, 106 Lands, A. M., and Cavallito, C. J. Evalua- Methamphetamine, transformation and dis- tion of the factors favorable for acetyl- position of, 315 choline-like stimulation by employing Millar, I. E., see Boyd, E. M., 443 a series of quaternary ammonium alkyl Miller, J. W., and Elliott, H. W. In vitro sulfide and sulfoxide compounds, 369 studies on the diphasic action of meth- see Luduena, F. P., 282 adone, 106 Langemann, H., see Kensler, C. J., 127 Milnes, F. J., see Fellows, E. J., 463 Lawler, C. A., see Cook, D. L., 293 Moe, G. K., see Rennick, B. R., 309 Leimbach, D. G., and Eddy, N. B. Synthetic Moran, N. C., Dresel, P. E., Perkins, M. E., analgesics. III. Methadols, isometha- and Richardson, A. P. Pharmacological dols, and their acyl derivatives, 135 actions of andromedotoxin, an active Levarterenol, comparison with epinephrine principle from rhododendron maxi- in intact anesthetized dog, 352 mum, 415 see Arterenol Moyer, J. H., see Handley, C. A., 277 Levy, L., Featherstone, R. M., and Vander Murtha, E. F., see McNamara, B. P., 232 Ploeg, R. A. Effect of xenon and nitrous oxide on in vitro guinea pig brain Neuromuscular blocking drug, excretion of respiration and oxidative phosphoryla- succinyldicholine, 392 tion, 221 Nirvanol, optical isomers of, anesthetic see Pittinger, C. B., 458 activity, distribution, elimination, rate Liver, effect of arterenol on hepatic blood of production from Mesantoin isomers, flow, 398 120 excretory mechanisms of, effects of hydro- Nitrous oxide, effect of, on brain respiration choleretic agents on, 293 and oxidative phosphorylation, 221 role of, in demethylation, 241 Norepinephrine, see Levarterenol Loewe, S. Potentiation of drug-produced Norton, S., and de Beer, E. J. Excretion of ejaculation by -diethylaminoethyl- succinyldicholine in urine of cat and diphenyipropylacetate, 271 mouse, 392 Luduena, F. P., and Lands, A. M. Investi- Nungesser, W. C., and Hiatt, E. P. Action of I #{163}!JX 475

veratrum on the renal circulation of epinephrine and levarterenol on, in the dog, 68 dog, 352 Renal function, effect on, of a dibenzazepine Okita, G. T., Kelsey, F. E., Walaszek, derivative (Ilidar), 277 E. J., and Ceiling, E. M. K. Biosyn- renal tubular secretion of TEA, 309 thesis and isolation of carbon-14 labeled Renal pharmacology, effect of veratrum on digitoxin, 244 renal circulation, 68 2 ,4-Oxazolidinedione, demethylation of N- Rennick, B. R., Calhoon, D. M., Gandia, methyl derivatives of, 241 H., and Moe, G. K. Renal tubular secretion of tetraethylammonium in the dog and the chicken, 309 Pamine bromide, actions of, 188 Rhododendron maximum, andromedotoxin, Panting, thermal, inhibition of, by pyrogen, active principle from, 415 339 Richards, R. K., see Goodsell, J. S., 251 Pentobarbital, effect of, on brain stem Richardson, A. P., see Moran, N. C., 415 arousal mechanism, 76 Robinson, E. M., Beck, R., McNamara, Perkins, M. E., see Moran, N. C., 415 B. P., Edberg, L. J., and Wills, J. H. pH, influence of, on d-tubocurarine action, Mechanism of action of anticholin- 433 esterase compounds on the patellar Phenylindanedione, disposition of in body, reflex, 385 451 see McNamara, B. P., 232 Phosphorylation, oxidative, effect on, of Roth, L. W. Blocking effects of a series of barbiturates, 148 oxidative, effect on, of xenon and nitrous substituted piperazines, 157 oxide, 221 Schiffman, D. 0., see Goodman, L. S., 403 Piperazines, pharmacology of several, 157 Pittinger, C. B., Featherstone, R. M., Schulert, A. R., and Weiner, M. Physiologic disposition of phenylindanedione in Gross, E. G., Stickley, E. E., and Levy, man, 451 L. Xenon concentration changes in Scopolamine, N -methyl bromide, actions brain and other body tissues of the dog of, 188 during inhalation of the gas, 458 Seay, P. H., see Visscher, F. E., 188 Plummer, A. J., see Trapold, J. H., 205 Seibert, R. A., and Handley, C. A. Evalua- Potassium, plasma, influence of, on mer- tion of some N-substituted arterenol curial diuresis, 361 derivatives as bronchodilators, 304 riscoline, adrenergic blockade by, effect Serpasil, cardiovascular and respiratory on, of denervation, 93 !‘yrogen, inhibition by, of thermal panting, effects of, 205 Smythe, C. McC., Gilmore, J. P., and Hand- 339 ford, S. W. Effect of l-norepinephrine on hepatic blood flow in the normal, Q uaternary ammonium compounds, evalua- anesthetized dog, 398 tion of factors in, favorable for Ach-like Sodium, plasma, influence of, on mercurial action, 369 diuresis, 361 excretion of succinyldicholine, 392 Stickley, E. E., see Pittinger, C. B., 458 see also d-Tubocurarine Streptomycin, effect of, on formation of adaptive enzyme in Pseudomonas, 115 Rakieten, N., see Hoekstra, J. B., 55 Strychnine, effect of, on brain stem arousal Rall, D. P., and Wells, J. A. Quantitative mechanism, 76 aspects of inhibition of thermal pant- Succinyldicholine, excretion of, 392 ing by pyrogen, 339 Sung, C., and Way, E. L. Fate of the optical Rauwolfia, see Serpasil isomers of alpha-acetylmethadol, 260 Rawson, C. W., Jr., see Ahiquist, R. P., 352 Swinyard, E. A., see Goodman, L. S., 403 Regitine, adrenergic blockade by, effect on, Sydow, V. L., see Ahiquist, R. P., 352 of denervation, 93 Sympathomimetic amines, arterenol de- Renal blood flow, comparative effects of rivatives as bronchodilators, 304 476 INDEX

metabolism of amphetamine and con- Waddell, W. J., see Butler, T. C., 120, 241 geners, 315 Walaszek, E. J., see Okita, G. T., 244 Way, E. L., see Sung, C., 260 Taylor, J. P., see Ahiquist, R. P., 352 Weiner, M., see Schulert, A. R., 451 TEA, secretion of by dog and chicken Wells, J. A., see Rail, D. P., 339 kidney, 309 Werner, H. W., see Brown, B. B., 180 TEPP, mechanism of action of, 232, 385 Whittlesey, P., and Zubrod, C. G. Effect Terramycin, effect of, on formation of adap- of intravenously administered fructose tive enzyme in Pseudomonas, 115 on the ketone bodies of the depancrea- Tisch, D. E., see Hoekstra, J. B., 55 tized dog, 226 Toman, J. E. P., see Goodsell, J. 5., 251 Wills, J. H., see McNamara, B. P., 232 Trapold, J. H., Plummer, A. J., and Yonk- see Robinson, E. M., 385 man, F. F. Cardiovascular and respira- Wilson, M., see Gardner, E. A., 166 tory effects of serpasil, a new crystal- Winbury, M. M. Coronary dilator action. line alkaloid from rauwolfia serpentina III. Effect of several antihistamine benth, in the dog, 205 compounds on coronary blood flow in Troxanol, a-ethyi-y-isopropyl glycerol the intact dog, 300 ether, as muscle relaxant, 251 Winne, R., see Gray, W. D., 327 d-Tubocurarine, comparison with dimethyl Witt, I. H., see Fellows, E. J., 463 dTc, 433 Witt, P. N., see Benforado, J. M., 334 ionization of, and influence of pH on, 433 Woske, H., Fastier, F. N., Belford, J., and Brooks, C. McC. Effect of induced Ullyot, G. E., see Fellows, E. J., 463 failure and digitalization on the ex- citability and rhythmicity of the dog’s Vander Brook, M. J., see Visscher, F. E., 188 heart, 215 Vander Ploeg, R. A., see Levy, L., 221 Veratridine, lethal dose of, influence on, of Xenon, as anesthetic, concentration in heart rate, in heart-lung, 334 tissues after inhalation, 458 Veratrum, comparison with andromedo- effect of, on brain respiration and oxida- toxin, 415 tive phosphorylation, 221 emetic action antagonized by Chiorpro- mazine, 86 Veratrum alkaloids, effect of, on renal Yonkman, F. F., see Trapold, J. H., 205 circulation, 68 Youmans, P. L., see Griffin, P. P., 93 Visscher, F. E., Seay, P. H., Tazelaar, A. P., Jr., Veldkamp, W., and Vander Brook, M. J. Pharmacology of Pamine Zirkle, C. L., see Kensler, C. J., 127 bromide, 188 Zubrod, C. G., see Whittlesey, P., 226

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