INDEX Abstracts, New Haven meeting, 1 Arterenol, derivatives of, as bronchodi- Acetate, iodo-, action of, on auricle, 166 lators, 304 Acetyicholine, see Quaternary ammonium effect of, on hepatic blood flow, 398 compounds inhibiting effect of, on histamine induced Acetylmethadols, and acetylisomethadols, gastric secretion, 447 as analgesic agents, 135, fate of, 260 see Levarterenol Adrenergic blockade, effect on, of denerva- vascular responses to, effect on, of de- tion of vascular areas, 93 nervation, 93 Adrenergic blocking drug, effect of Ilidar Atropine, comparison of, to Centrine, 55 on renal function, 277 Aureomycin, absorption of, enhancement series of B-chloroethylamines, 463 by citric acid, 327 Ahlquist, R. P., Taylor, J. P., Rawson, effect of, on formation of adaptive enzyme C. W., Jr., and Sydow, V. L. Compara- in Pseudomonas, 115 tive effects of epinephrine and levar- Autonomic blocking action, of piperazines, terenol in the intact anesthetized dog, 157 352 Axeirod, J. Studies on sympathomimetic Aminopentamide, actions of, 55 amines. II. Biotransformation and Amphetamine, p-hydroxy, transformation physiological disposition of d-amphet- and disposition of, 315 amine, d-p-hydroxyamphetamine and transformation and disposition of, 315 d-methamphetamine, 315 Analgesic agents, see Methadols, Isometh- adols Bain, J. A., see Brody, T. M., 148 Andromedotoxin, actions of, 415 Barbiturates, effect of, on oxidative phos- Anectine, see Succinyldicholine phorylation, 148 Anesthetics, general, xenon, concentration ejaculation produced by, 271 in tissues after inhalation, 458 see Pentobarbital general, see Xenon, Nitrous Oxide Beck, R., see Robinson, E. M., 385 Antibiotics, effect of, on formation of adap- Belford, J., see Woske, H., 215 tive enzyme in Pseudomonas, 115 Bender, C. W., see McNamara, B. P., 232 see Aureomycin Benforado, J. M., and Witt, P. N. Influence Anticholinesterases, mechanism of action of of heart rate upon the lethal dose of DFP and TEPP, 385 veratridine in the heart-lung prepara- see DFP, TEPP tion of the dog, 334 Anticoagulants, phenylindanedione, dispo- Bergner, A. D., see McNamara, B. P., 232 sition of, 451 Bernheim, F. Effect of certain antibiotics Anticonvulsant, properties of 5,5-diphenyl- on the formation of an adaptive enzyme tetrahydroglyoxaline - 4 - one, SKF in a strain of Pseudomonas aeruginosa, 2599, 403 115 diphenyihydantoin, 403 Blocking action, of piperazines, 157 Antihistamines, coronary dilator action of, Borison, H. L., see Brand, E. D., 86 300 Boyd, E. M., and Millar, I. E. Lack of effect piperazines as, 157 of codeine phosphate and dihydro- Antispasmodic compounds, and metho salts, codeinone bitartrate upon the volume pharmacology of, 282 output, specific gravity, relative vis- Apomorphine, emetic action antagonized by cosity and chloride content of respira- chiorpromazine, 86 tory tract fluid, 443 Arduini, A., and Arduini, M. G. Effect of Brain stem activity, effect on, of various drugs and metabolic alterations on drugs, 76 brain stem arousal mechanism, 76 Brand, E. D., Harris, T. D., Borison, H. L., Arduini, M. G., see Arduini, A., 76 and Goodman, L. S. Anti-emetic activ- 471 472 INDEX ity of 10-(-y-dimethylaminopropyl)-2- Cholinergic drug, tetrakis-(dimethylamino- chlorophenothiazine (Chiorpromazine) methyl) methane tetramethobromide, in dog and cat, 86 127 Brody, T. M., and Bain, J. A. Barbiturates Cholinesterase, inhibition of, and DFP and and oxidative-phosphorylation, 148 TEPP, 385 Bronchodilators, arterenol derivatives as, Citric acid, enhancement by, of absorption 304 of aureomycin, 327 Bronchosecretion, effect on, of codeine and Code, C. F., see Forrest, A. P. M.,447 dihydrocodeinone, 443 Codeine, effect of, on bronchial secretions, Brooks, C. McC., see Woske, H., 215 443 Brown, B. B., and Werner, H. W. Pharma- Cook, D. L., Lawler, C. A., and Green, cologic studies on a new central stimu- D. M. Studies on the effect of hydro- lant, a-(2-piperidyl)benzhydrol hydro- choleretic agents on hepatic excretory chloride (Dol), 180 mechanisms, 309 Brown, W. C., see Goodman, L. S., 403 Copper sulfate, emetic action antagonized Butler, T. C., and Waddell, W. J. Pharmaco- by Chlorpromazine, 86 logical comparison of the optical Coronary arteries, action on, as dilators, of isomers of 5-ethyl-5-phenyl hydantoin antihistamines, 300 (Nirvanol) and of 3-methyl-5-ethyl-5- Cunningham, R. W., see Gray, W. D., 327 phenyl hydantoin (Mesantoin), 120 Curare, see d-Tubocurarine -, and Waddell, W. J. Role of the liver in Cyanide, sodium, effect of, on brain stem the demethylation of N-methyl deriva- arousal mechanism, 76 tives of hydantoin and 2,4-oxazoli- dinedione, 241 de Beer, E. J., see Norton, 5., 392 Demethylation, role of liver in, in deriva- tives of hydantoin and 2,4-oxazoli- Calhoon, D. M., see Rennick, B. R., 309 dinedione, 241 Cardiac pharmacology, action of iodoace- DFP, mechanism of action of, 232, 385 tate on rabbit auricle, 166 Dibenzyline, actions of, 463 cardiovascular actions of andromedo- Dickison, H. L., see Hoekstra, J. B., 55 toxin, 415 Digitalization, effect of, on excitability and effect of induced failure and digitaliza- rhythmicity of the dog’s heart, 215 tion on excitability and rhythmicity of Digitoxin, synthesis and isolation of C’ the dog’s heart, 215 labeled, 244 influence of heart rate on lethal dose of Dihydrocodeinone, effect of, on bronchial veratridine in heart-lung, 334 secretions, 443 relation of sugar moieties to action of Dilantin, see Diphenylhydantoin cardiac glycosides on embryonic chick Dinitrophenol, effect of, on oxidative phos- heart, 411 phorylation, comparison with barbitu- see also Coronary arteries rates, 148 see Serpasil Dioxolanes, as muscle relaxants, 251 Cavallito, C. J., see Lands, A. M., 369 Diphenylhydantoin, anticonvulsant po- Central stimulant, actions of a new, 180 tency and toxicity of, 403 Centrine, activity of, 55 5,5 - Diphenyl - tetrahydroglyoxaline - 4 - Chenoweth, M. B., see Hendershot, L. C., one, anticonvulsant potency and toxic- 344 ity of, 403 Chioramphenicol, effect of, on formation of Dragstedt, C. A., see Keyl, A. C., 411 adaptive enzyme in Pseudomonas, 115 Dresel, P. E., see Moran, N. C., 415 -Chloroethylamines, series of, 463 Chiorpromazine, as anti-emetic, 86 Edberg, L. J., see Robinson, E. M., 385 Chiortetracycline, see Aureomycin Eddy, N. B., see Leimbach, D. G., 135 Cholinergic compounds, evaluation of fac- Ejaculation, drug-produced, enhancement tors in ammonium compounds favorable by SKF No. 525A, 271 for Ach-like action, 369 Elliott, H. W., see Miller, J. W., 106 INDEX 473 Emesis, produced by morphine, ergot, vera- Glycosides, cardiac, relation of glucose to trum, copper sulfate, lanatoside-C, action on embryonic chick heart, 411 antagonism by Chlorpromazine, 86 cardiac, see Digitoxin Epinephrine, comparison with levarterenol Goodman, L. S., Swinyard, E. A., Brown, in intact anesthetized dog, 352 W. C., and Schiffman, D. 0. Anticon- inhibiting effect of, on histamine induced vulsant properties of 5,5-diphenyl- gastric secretion, 447 tetrahydroglyoxaline-4-one (SKF No. vascular responses to, effect on, of de- 2599), 403 nervation, 93 see Brand, E. D., 86 Ergot, emetic action antagonized by Chlor- Goodsell, J. S., Toman, J. E. P., Everett, promazine, 86 G. M., and Richards, R. K. Search for Ether, effect of, on brain stem arousal more effective muscle relaxants among mechanism, 76 the glycerol ethers and dioxolanes, 251 Everett, C. M., see Goodsell, J. S., 251 Gray, W. D., Hill, R. T., Winne, R., and Cunningham, R. W. Enhancement of chlortetracycline absorption by citric Farah, A., and Koda, F. Influence of plasma acid, 327 electrolyte concentration on mercurial Green, D. M., see Cook, D. L., 293 diuresis in the dog, 361 Green, H. D., see Griffin, P. P., 93 see Gardner, E. A., 166 Griffin, P. P., Green, H. D., Youmans, Fastier, F. N., see Woske, H., 215 P. L., and Johnson, H. D. Effect of Fatty acids, antagonism to fluoroacids, 344 acute and chronic denervation of the Featherstone, R. M., see Levy, L., 221 hind leg of the dog on the blood flow see Pittinger, C. B., 458 responses in the vascular beds of skin Fellows, E. J., McLean, R. A., Macko, E., and muscle to adrenergic drugs, and to Kerwin, J. F., Hall, G. C., Milnes, F. J., adrenergic blockade, 93 Witt, I. H., and Ullyot, G. E. Oral and Gross, E. G., see Pittinger, C. B., 458 intravenous adrenolytic activity of a number of N-benzyl-N-phenoxyethyl Hall, C. C., see Fellows, E. J., 463 and N-benzyl-N-phenoxyisopropyl-$- Handford, S. W., see Smythe, C. McC., 398 chloroethylamines, 463 Handley, C. A., and Moyer, J. H. Effect of a Fluoroacetate, antagonism by fatty acids, dibenzazepine derivative (Ilidar) on 344 renal function, 277 Fluorobutyrate, antagonism by fatty acids, see Seibert, R. A., 304 344 Harris, T. D., see Brand, E. D., 86 Fluorohexanoate, antagonism by fatty Hendershot, L. C., and Chenoweth, M. B. acids, 344 Antagonism of three homologous mono- Forrest, A. P. M., and Code, C. F. Inhibit- fluorinated fatty acids by several fatty ing effect of epinephrine and norepi- acids, 344 nephrine on secretion induced by hist- Hepatic, see Liver amine in separated pouches in dogs, 447 Hiatt, E. P., see Nungesser, W. C., 68 Fructose, effect of, on ketone bodies, 226 Hill, R. T., see Gray, W. D., 327 Histamine, as secretagogue, inhibition by Gandia, H., see Rennick, B. R., 309 epinephrine and arterenol, 447 Ganglionic blockade, by piperazines, 157 Hoekstra, J. B., Tisch, D. E., Rakieten, N., Gardner, E. A., Wilson, M., and Farah, A. and Dickison, H. L. Pharmacological