Form 20-F // YE 2018 Including Management Report (IFRS)

Form 20-F // YE 2018 Including Management Report (IFRS) REFERENCE TABLE 20-F ...... ii 1. INTRODUCTION ...... 1 2. SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS ...... 1 3. RISK FACTORS ...... 2 Risks Related to Our Financial Condition ...... 2 Risks Related to the Development, Clinical Testing and Commercialization of Our Product Candidates ...... 5 4. GROUP MANAGEMENT REPORT ...... 42 a) Operations and Business Environment ...... 43 b) Operating and Financial Review and Prospects ...... 72 c) Outlook and Forecast ...... 88 d) Shares and the Capital Market ...... 93 e) Sustainable Business Development ...... 97 f) Risk and Opportunity Report ...... 103 g) Statement on Corporate Governance, Group Statement on Corporate Governance and Corporate Governance Report ...... 114 h) Subsequent Events ...... 147 5. ADDITIONAL BUSINESS INFORMATION ...... 148 6. GOVERNMENT REGULATION ...... 189 7. OTHER INFORMATION ...... 204 8. RELATED PARTY TRANSACTIONS ...... 206 9. PRINCIPAL SHAREHOLDERS ...... 206 10. DESCRIPTION OF SHARE CAPITAL ...... 208 11. DESCRIPTION OF AMERICAN DEPOSITARY SHARES ...... 213 12. EXCHANGE CONTROLS AND LIMITATIONS AFFECTING SHAREHOLDERS ...... 214 13. CONTROLS AND PROCEDURES ...... 214 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES ...... 215 15. DOCUMENTS ON DISPLAY ...... 215 16. TAXATION ...... 215 17. APPENDIX ...... 228 INDEX TO FINANCIAL STATEMENTS ...... F-1 EXHIBIT INDEX

i REFERENCE TABLE 20-F

Item Form 20-F Caption Location in this document Page Part I 1 Identity of Directors, Senior Management and Advisors Not applicable — 2 Offer Statistics and Expected Timetable Not applicable — 3 Key Information A. Selected Financial Data Group Management Report – Operating and Financial Review and Prospects – Multi-Year Overview – Statement of Profit or Loss 78 Group Management Report – Operating and Financial Review and Prospects – Multi-Year Overview – Balance Sheet Structure 83 B. Capitalization and Indebtedness Not applicable C. Reasons for the Offer and Use of Proceeds Not applicable D. Risk Factors Risk Factors 2-42 4 Information on the Company A. History and Development of the Company Group Management Report – Operations and Business Environment – Organizational Structure 46 Group Management Report – Operations and Business Environment – Group Development 65-66 Group Management Report – Operations and Business Environment – Investments 81 Documents on Display 215 B. Business Overview Introduction 1 Group Management Report – Operations and Business Environment – Business Activities 47-50 Group Management Report – Operations and Business Environment – Research Development and Business Performance 50-65 Group Management Report – Operations and Business Environment – Patents 65 Group Management Report – Operating and Financial Review and Prospects – Investments 81 Group Management Report – Sustainable Business Development – Intellectual Property 102 Additional Business Information – Business Overview 148-189 Additional Business Information – Government Regulation 189-204 C. Organizational Structure D. Property, Plant and Equipment Additional Business Information – Other Information – Facilities 204

ii 4A Unresolved Staff Comments Not applicable 5 Operating and Financial Review and Prospects A. Operating Results Group Management Report – Operating and Financial Review and Prospects – Results of Operations 72-78 B. Liquidity and Capital Resources Group Management Report – Operating and Financial Review and Prospects – Liquidity and Capital Resources 79-81 Group Management Report – Operating and Financial Review and Prospects – Investments 81 C. Research and Development, Patents and Licenses, etc. Group Management Report – Operations and Business Environment – Research Development and Business Performance 50-65 D. Trend Information Group Management Report – Operations and Business Environment – Changes in the Business Environment 69-71 Group Management