nm u Ottawa L'Universite canadienne Canada's university run FACULTE DES ETUDES SUPERIEURES l=J FACULTY OF GRADUATE AND ET POSTOCTORALES U Ottawa POSDOCTORAL STUDIES L'Unneisue Matias Alvarez-Saavedra AUTEUR DE LA THESE / AUTHOR OF THESIS M.Sc. (Biochemistry) GRADE/DEGREE Department of Biochemistry, Microbiology and Immunology MicroRNA-132-Dependent Post-Transcriptional Regulation of Clock Entrainment Physiology Via Modulation of Chromatin Remodeling and Translational Control Gene Targets TITRE DE LA THESE / TITLE OF THESIS Mary Cheng "WRKTEUTPRE^ CO-DIRECTEUR (CO-DIRECTRICE) DE LA THESE / THESIS CO-SUPERVISOR David Lohnes Adam Rudner Gary W. Slater Le Doyen de la Faculte des etudes superieures et postdoctorales / Dean of the Faculty of Graduate and Postdoctoral Studies MicroRNA-132-Dependent Post-Transcriptional Regulation of Clock Entrainment Physiology Via Modulation of Chromatin Remodeling and Translational Control Gene Targets M.Sc. Thesis in partial fulfillment of the requirements for the degree Master of Science (M.Sc.) in the Biochemistry Program at the University of Ottawa, Faculty of Medicine Ottawa, Ontario, Canada Sliihmil'l-P'rl hv " "J ©Matias Alberto Alvarez-Saavedra, Ottawa, Canada, 2010 1 Library and Archives Bibliotheque et 1*1 Canada Archives Canada Published Heritage Direction du Branch Patrimoine de I'edition 395 Wellington Street 395, rue Wellington Ottawa ON K1A 0N4 OttawaONK1A0N4 Canada Canada Your file Votre reference ISBN: 978-0-494-73802-3 Our file Notre r6f6rence ISBN: 978-0-494-73802-3 NOTICE: AVIS: The author has granted a non L'auteur a accorde une licence non exclusive exclusive license allowing Library and permettant a la Bibliotheque et Archives Archives Canada to reproduce, Canada de reproduce, publier, archiver, publish, archive, preserve, conserve, sauvegarder, conserver, transmettre au public communicate to the public by par telecommunication ou par I'lntemet, preter, telecommunication or on the Internet, distribuer et vendre des theses partout dans le loan, distribute and sell theses monde, a des fins commerciales ou autres, sur worldwide, for commercial or non support microforme, papier, electronique et/ou commercial purposes, in microform, autres formats. paper, electronic and/or any other formats. The author retains copyright L'auteur conserve la prophete du droit d'auteur ownership and moral rights in this et des droits moraux qui protege cette these. Ni thesis. Neither the thesis nor la these ni des extra its substantiels de celle-ci substantial extracts from it may be ne doivent etre imprimes ou autrement printed or otherwise reproduced reproduits sans son autorisation. without the author's permission. In compliance with the Canadian Conformement a la loi canadienne sur la Privacy Act some supporting forms protection de la vie privee, quelques may have been removed from this formulaires secondaires ont ete enleves de thesis. cette these. While these forms may be included Bien que ces formulaires aient inclus dans in the document page count, their la pagination, il n'y aura aucun contenu removal does not represent any loss manquant. of content from the thesis. 1+1 Canada Thesis Supervisor: Dr. Hai-Ying Mary Cheng, Department of BMI, University of Ottawa Thesis Examiners: Dr. David Lohnes, Department of CMM, University of Ottawa Dr. Adam Rudner, Department of BMI, University of Ottawa Date of Thesis Submission: August 20th, 2010. 2 ABSTRACT Mammalian circadian rhythms of behaviour are synchronized to external time by daily resetting of the master pacemaker, the suprachiasmatic nucleus (SCN), in response to light, in a process known as light-induced clock entrainment. microRNA-132 (miR-132) is induced by light within the SCN via a MAPK-CREB-depen
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