HISTOPATHOLOGICAL PATTERN OF BENIGN SOFT TISSUE TUMOURS IN
THE UNIVERSITY COLLEGE HOSPITAL, IBADAN, NIGERIA-A
RETROSPECTIVE STUDY: 1970-2002
BY
Dr Gabriel Olabiyi OGUN
MB, BS (Ilorin)
Department of Pathology,
University College Hospital, Ibadan, Nigeria
A dissertation submitted in part fulfilment of the requirements for the award
of the Fellowship of the National Postgraduate Medical College of Nigeria
(FMCPath)
November 2005
TABLE OF CONTENTS
Page Cover page і
Table of Contents іі
List of Tables iii
List of Figures iv
Certification v
Declaration vi
Acknowledgement vii
Dedication viii
Abstract ix
Introduction 1
Literature Review 2-12
Aims and objectives 13
Materials and methods 14
Results 15-24
Discussion 25-30
Conclusion 31
References 32-38
Appendix 39-49 iii
LIST OF TABLES Page 2.1 Inherited benign soft tissue tumours 5
2.2 Cytogenetic characteristics 11
5.1 Frequencies of soft tissue tumours 22
5.2 Summary of benign soft tissue tumours 23
5.3 Site distribution 24
iv
LIST OF FIGURES Page Figure 1 Age and sex distribution 18
Figure 2 Percentages of individual vascular tumours 18
Figure 3 Photomicrograph of cystic lymphangioma 19
Figure 4 Percentages of individual neural tumours 19
Figure 5 Photomicrograph of plexiform neurofibroma 20
Figure 6 Photomicrograph of granular cell tumour 20
Figure 7 Percentages of individual fibrous tumours 21
Figure 8 Photomicrograph of infantile fibromatosis 21
v
CERTIFICATION
This is to certify that the study described was done by
Dr. Gabriel Olabiyi OGUN while he was a resident in
Pathology in the Department of Pathology of the University
College Hospital, Ibadan under our Supervision.
------
Prof E.E Akang M.B, B.S, FMCPath, FWACP
------
Prof J.O Ogunbiyi M.B, B.S, FWACP
vi
DECLARATION
I hereby declare that this work is original unless otherwise acknowledged. This work has not been presented to any other college for a degree or fellowship, nor has it been submitted elsewhere for publication.
------
Dr. Gabriel Olabiyi OGUN
vii
ACKNOWLEDGEMENT
This work from the very beginning had inputs of my teachers Prof E.E Akang and
Prof J.O Ogunbiyi, who were also my supervisors for this study and Dr O.A
Oluwasola. They suggested the topic, encouraged and directed me on the study. I am indebted to them.
My profound gratitude goes to my colleagues Dr Clement Okolo and Dr Tope
Oyebadejo. Your friendship has been exemplary.
My gratitude also goes to Dr Gbolabo Adetunji, Dr U Eze, Dr Femi Ariyibi, Dr Seun
Akinpelu, Dr Funmi Makanjuola, Dr Seun Olasunkanmi and Dr Iyabo Gbadamosi for helping with the retrieval of the records, slides and tissue blocks despite severe constraints and stress.
My thanks also go to Mrs Lawal and Mr Ajibade, both laboratory scientists in the department for their help.
I thank all members of staff of the Department of Pathology, University College
Hospital, Ibadan.
Ultimately to the Almighty God, who made it all possible. Without Him it would have been impossible.
viii
DEDICATION
To my GOD Almighty, the giver of life, who made it all possible.
To my darling and loving wife: - Olufunmilola. You have kept the home front well; I love and appreciate you very much.
To my children, Seyi and Segun - wonderful and loving sons. You give me joy which is unquantifiable. Seyi, sorry for the few times I forgot you in school while this project was on.
To my parents in Abeokuta and Ibadan – you have always been there. I am short of words. I appreciate you very much