HISTOPATHOLOGICAL PATTERN OF BENIGN TUMOURS IN

THE UNIVERSITY COLLEGE HOSPITAL, IBADAN, NIGERIA-A

RETROSPECTIVE STUDY: 1970-2002

BY

Dr Gabriel Olabiyi OGUN

MB, BS (Ilorin)

Department of Pathology,

University College Hospital, Ibadan, Nigeria

A dissertation submitted in part fulfilment of the requirements for the award

of the Fellowship of the National Postgraduate Medical College of Nigeria

(FMCPath)

November 2005

TABLE OF CONTENTS

Page Cover page і

Table of Contents іі

List of Tables iii

List of Figures iv

Certification v

Declaration vi

Acknowledgement vii

Dedication viii

Abstract ix

Introduction 1

Literature Review 2-12

Aims and objectives 13

Materials and methods 14

Results 15-24

Discussion 25-30

Conclusion 31

References 32-38

Appendix 39-49 iii

LIST OF TABLES Page 2.1 Inherited benign soft tissue tumours 5

2.2 Cytogenetic characteristics 11

5.1 Frequencies of soft tissue tumours 22

5.2 Summary of benign soft tissue tumours 23

5.3 Site distribution 24

iv

LIST OF FIGURES Page Figure 1 Age and sex distribution 18

Figure 2 Percentages of individual vascular tumours 18

Figure 3 Photomicrograph of cystic lymphangioma 19

Figure 4 Percentages of individual neural tumours 19

Figure 5 Photomicrograph of plexiform neurofibroma 20

Figure 6 Photomicrograph of granular cell tumour 20

Figure 7 Percentages of individual fibrous tumours 21

Figure 8 Photomicrograph of infantile 21

v

CERTIFICATION

This is to certify that the study described was done by

Dr. Gabriel Olabiyi OGUN while he was a resident in

Pathology in the Department of Pathology of the University

College Hospital, Ibadan under our Supervision.

------

Prof E.E Akang M.B, B.S, FMCPath, FWACP

------

Prof J.O Ogunbiyi M.B, B.S, FWACP

vi

DECLARATION

I hereby declare that this work is original unless otherwise acknowledged. This work has not been presented to any other college for a degree or fellowship, nor has it been submitted elsewhere for publication.

------

Dr. Gabriel Olabiyi OGUN

vii

ACKNOWLEDGEMENT

This work from the very beginning had inputs of my teachers Prof E.E Akang and

Prof J.O Ogunbiyi, who were also my supervisors for this study and Dr O.A

Oluwasola. They suggested the topic, encouraged and directed me on the study. I am indebted to them.

My profound gratitude goes to my colleagues Dr Clement Okolo and Dr Tope

Oyebadejo. Your friendship has been exemplary.

My gratitude also goes to Dr Gbolabo Adetunji, Dr U Eze, Dr Femi Ariyibi, Dr Seun

Akinpelu, Dr Funmi Makanjuola, Dr Seun Olasunkanmi and Dr Iyabo Gbadamosi for helping with the retrieval of the records, slides and tissue blocks despite severe constraints and stress.

My thanks also go to Mrs Lawal and Mr Ajibade, both laboratory scientists in the department for their help.

I thank all members of staff of the Department of Pathology, University College

Hospital, Ibadan.

Ultimately to the Almighty God, who made it all possible. Without Him it would have been impossible.

viii

DEDICATION

To my GOD Almighty, the giver of life, who made it all possible.

To my darling and loving wife: - Olufunmilola. You have kept the home front well; I love and appreciate you very much.

To my children, Seyi and Segun - wonderful and loving sons. You give me joy which is unquantifiable. Seyi, sorry for the few times I forgot you in school while this project was on.

To my parents in Abeokuta and Ibadan – you have always been there. I am short of words. I appreciate you very much