Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001049335Cyc: Brenneria goodwinii OBR1 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

cob(I)inamide molybdate molybdate thiamine phosphate phosphate cob(I)alamin

YejB RS18010 RS14805 RS03785 MscM SecE RS17725 RS05720 RS00655 SsuC BtuD LptB RS04615 RS20200 ModC ModF RS07735 DsbB LptG OppB RS19395 YidC SohB RsxG RS15220 RS19160 RS07820 RS00840 FtsB PhnE FhuB RS12605 FtsA PutP KefG RS12910 RS04315 ThiQ BcsB RarD RS18640 SstT PotA RS07160 RS22220 RS22170 RS14420 RS10350 RS02860 RS12970 RS02850 RS22020 RS06535 TolR PspC FtsY RS14970 RS18340 RS06445 MscS RS14040 RS08160 FtsI SapC FlhB UbiB CpxA RS02730 FlhA RS01300 MotA GlnK RS21735 GsiC NlpI RS07545 RS02795 TatA RS16345 RS04050 TolQ RS22005 YajC TauC RS22090 RS04300 RS08815 RS06620 RS03145 RS14525 RS04230 RS13675 PstB PstB ElaB RS22450 RS06785 RS10875 RS01715 RS01745 RS22545 RS14810 RS08640 RsxG RS18870 RS11325 RS07250 RS22895 RS22955 RsxB RS15285 NtrB PotH PotA RS19495 RS16950 MdtG RS07625 ManX ArcB RS08105 RS04905 FeoB MetI SecY GspE RS02480 RS02510 RS20795 RS08205 RcsD RS21135 RS13550 RS18140 RS02725 RS01280 PhnE FliR PsiE FliQ FliM UgpA FliL FliJ RS10950

RS13735 RS13745 cob(I)inamide molybdate molybdate thiamine cob(I)alamin phosphate phosphate LivM LapB

RS13620 RS13625 RS06340 RS14160 Degradation/Utilization/Assimilation - Other 6 an inactive 4-amino-4- α-Kdo-(2->4)- an O - a peptidoglycan L-alanyl-γ-D- a [protein]- a [bis(guanylyl β-D-fructofuranose S-(hydroxymethyl) a [elongation- a cis-delta21-39- N-acetyl-α- N-β-aspartyl- queuosine at a [protein] Cofactor, Carrier, and Vitamin Biosynthesis superpathway of β-D- Carboxylate Degradation a reduced a peptidoglycan a [protein]- phosphoenol an L-alanyl- biotin biosynthesis I flavin biosynthesis I (bacteria and plants) menaquinol-9 biosynthesis pyruvate decarboxylation to acetyl CoA I ribonucleoside SAM deoxy-α-L- α-Kdo-(2->6)- methylguanine glutamyl-meso-2,6- FAD molybdopterin) a [glutamine- (R)-β-lysine Factor-EF- oxo-40-methyl- D-muramoyl- glu position 34 C-terminal glu FtsX superpathway of ubiquinol-8 cob(II)yrinate a,c- superpathway of menaquinol-8 biosynthesis I superpathway of [2Fe-2S] iron-sulfur ubiquinol-8 biosynthesis superpathway of tetrahydrofolate biosynthesis superpathway of adenosylcobalamin salvage from cobinamide I NAD salvage thiamine diphosphate salvage II 5-methoxybenzimidazolyl adenosylcobamide Aromatic Compound Biosynthesis Fermentation mixed acid fermentation L-ascorbate degradation L-ascorbate D-galacturonate superpathway of D-glucarate acetoacetate L-cysteine dimer with L-threonine cys ATP 1-phosphate glutathione L-arginine dGDP pyruvate [tRNA Pro ] ATP FtsE RS07365 RS13480 glucuronosides degradation acrylonitrile flavodoxin synthetase]- Asp biosynthesis (early decarboxylation) demethylmenaquinol-8 biosynthesis I biosynthesis from adenosylcobinamide-GDP II (bacterial, aerobic) and D-galactarate degradation degradation triphosphate arabinopyranosyl lipid IV (E. coli) in DNA pentapeptide diaminopimeloyl- UDP-N-acetyl- cofactor formate P]-L-lysine C59:1-[acp]cyclopropane fatty L-alanine(1-) of a tRNA L-glutamate biotin diamide biosynthesis I cluster biosynthesis (late decarboxylation) pathway IV (from degradation I degradation I pyruvate degradation I A L-tyrosine 4-amino-2-methyl-5- a [pyruvate dehydrogenase reductase ditrans,octacis stems (meso- D-alanine α-D-muramate chaperone]- hydrogenlyase acyl phospholipid a malonyl-[acp] (early cobalt insertion) chorismate cob(II)inamide nicotinamide riboside) demethylmenaquinol-9 chorismate biosynthesis I phosphoenolpyruvate a β-D-glucuronoside (bacterial, anaerobic) aldehydo-D- dehydrogenase (to acetyl CoA) N-acetylmuramoyl- FAD:protein FMN class II fructose- salicylate biosynthesis I 6 -undecaprenyl bifunctional L-cysteine transcriptional isoaspartyl malonyl-ACP O- chorismate chorismate GTP 1-(β-D pyrimidinemethanol 5-methoxybenzimidazole 2,3-dihydroxybenzoate L-ascorbate galactarate D-glucarate E2 protein] N -lipoyl-L-lysine L-alanine diaminopimelate elongation synthase: N-acetylmuramoyl- tRNA 30S Cys- IPP uroporphyrinogen-III L-cysteine desulfurase GTP bifunctional L-ascorbate galacturonate pyruvate(acetyl-transferring) acetoacetate acrylonitrile transferase: bisphosphate peptidase/L- RS10190 methyltransferase isochorismate ribofuranosyl) bifunctional biosynthesis glucuronate phosphate DNA-binding containing) bifunctional [glutamate- activator BN1221_RS05130 L-alanine pyruvate tRNA(Pro) bifunctional cob(I)yrinic acid a,c-diamide demethylmenaquinone pyruvate , homodimeric acetate CoA- anaerobic amidase UDP-N- BN1221_RS07405 aldolase: fbaA factor P--(R) asparaginase: glutamyl- ribosomal RS04360 RS04240 RS22715 uroporphyrinogen-III isochorismate nicotinamide nicotinate-nucleotide-- D-erythrose 4-phosphate phosphoenolpyruvate pyruvate kinase isomerase: transcriptional -ammonia ligase]- FlhA: flhA kinase biotin-- BioC: bioC isopentenyl- synthase cysteine desulfurase: chorismate adenosyltransferase: cobO multifunctional hydroxymethylpyrimidine methyltransferase/2- chorismate galactarate glucarate dehydrogenase type: aceE transferase ribonucleoside- AmiB: amiB acetylmuramate:L- cysteine -beta-lysine cyclopropane fatty amidase Q(34) protein /Cys- a malonyl-[acp] C-methyltransferase: synthase GTP GTP cyclohydrolase dimethylbenzimidazole phospho-2-dehydro- chorismate carboxylase: uxaC regulator/O6- FAD:protein class I fructose- BN1221_RS18320 PykF: pykF diphosphate MenF: menF BN1221_RS13370 lyase: ubiC transcriptional kinase/ methoxy-6-polyprenyl- isochorismate PykF: pykF dehydroascorbate L-ascorbate subunit alpha: atoD triphosphate lipid IV(A) 4- alanyl-gamma-D- adenylyl-L-tyrosine S-(hydroxymethyl) ligase: epmA acyl phospholipid AmiB: amiB synthetase S6--L- tRNA(Cys) [acetyl-CoA- methyl ester cobA MenF: menF all-trans- cyclohydrolase II: ribA phosphoribosyltransferase: 3-deoxyheptonate D-glucopyranuronate dehydratase: dehydratase: complex acrylamide 1,6-anhydro-N- methylguanine-DNA N-acetylmuramoyl- FMN desulfurase bisphosphate isoaspartyl Delta-isomerase: [+ 2 isozymes] [corrinoid adenosyltranferase]-cob(II)inamide phosphomethylpyrimidine isochorismate synthase MenF: menF BN1221_RS08420 pyruvate kinase: pyk 6-phosphate glucuronate pyruvate acetoacetyl-CoA reductase- amino-4-deoxy-L- glutamyl- meso- phosphorylase/ glutathione pyruvate GluQRS: glutamate deacylase carboxylase] [+ 4 isozymes] octaprenyl I FolE: folE regulator/nicotinamide- 1,4-benzoquinol aldolase: garD gudD dihydrolipoyllysine- acetylmuramyl- L-alanine NifS: nifS aldolase: fbaB synthase: 1,6-anhydro-N- RS01060 beta-ketoacyl- BN1221_RS16645 uroporphyrinogen-III [+ 2 isozymes] 4-hydroxybenzoate 2,5-diamino-6-(5-phospho-D- cobT synthase MenF: menF isomerase: dehydrogenase methyltransferase transferase [glutamate-- peptidase/L- kinase: pyk ligase/biotin diphosphate 7,8- nucleotide kinase: thiD methylase UbiE: ubiE [+ 2 isozymes] L-ascorbate residue amidase: activating L-alanine arabinosyltransferase: amidase diaminopimelate [+ 4 isozymes] dehydrogenase/ a [elongation- BN1221_RS18020 acetylmuramyl- gluQRS ligase: rimK YbaK: ybaK FieF ACP synthase C-methyltransferase: isochorismate an S-sulfanyl-[L- ribosylamino)pyrimidin-4(3H)-one BN1221_RS07600 complex Ada: ada ApbE: apbE asparaginase: adenylyltransferase/ 5-methoxybenzimidazole [+ 2 isozymes] isochorismate uxaC acetyl-CoA C- protein: nrdG arnT ligase: mpl ammonia-ligase] class III alcohol Factor-EF-P]-N 6 a cis-keto-C60- operon RS22105 RS07275 isochorismate cysteine desulfurase] dihydroneopterin menaquinol-9 [+ 3 isozymes] oxaloacetate pyruvate 6-phosphate 5-dehydro-4- acetyltransferase: BN1221_RS15235 amidase AmiB: amiB L-alanine II: fabF DMAPP cobA bifunctional HMP-P adenosylcobinamide-GDP ribotide phosphate isochorismate D-tagaturonate dihydrolipoyllysine- acetyltransferase: adenylyltransferase: β meroacyl-[acp] BN1221_RS08185 repressor 4-hydroxybenzoate 3'-triphosphate ribosylnicotinamide 5-methylbenzimidazolyl adenosylcobamide 3-deoxy-D-arabino- 2,3-didehydro- lactonase: deoxy-D-glucarate aceF D-glucarate [+ 2 isozymes] AmpD: ampD methylated-DNA-- 1,6-anhydro-N- a [bis(guanylyl DHAP D-glyceraldehyde dehydrogenase: -( -lysyl)-L-lysine amidase glutamyl- a [protein] C- beta-ketoacyl- precorrin-1 2-succinyl-6- isochorismate lyase: aldehydo-D-glucuronate pyruvate residue BN1221_RS21880 glnE pyruvate BirA: birA 2-succinyl-6- octaprenyltransferase: dihydroneopterin diaminohydroxyphosphoribosylaminopyrimidine kinase NadR: nadR biosynthesis from adenosylcobinamide-GDP heptulosonate 7-phosphate degradation II an active 4'-α-L-Ara4N di-trans,octa-cis [protein]-cysteine S- a [protein]-FMN- BN1221_RS21215 AmpD: ampD α ala a tRNA Pro (2E,6E)- hydroxy-2, 4- [corrinoid adenosyltranferase]-cob(I)inamide 5-(2-hydroxyethyl) bifunctional L-gulonate ulaG tagaturonate 2-dehydro-3- [+ 2 isozymes] acetyltransferase: acetylmuramyl- UDP-N-acetylmuramoyl- ala molybdopterin) dGTP queuosine at terminal -L- PotI ACP synthase hydroxy-2, 4- deaminase/5-amino-6-(5-phosphoribosylamino) NMN BN1221_RS04740 malate/lactate/ formate D-lactate dehydrogenase a [pyruvate dehydrogenase [+ 2 isozymes] acrylate 5'-deoxyadenosine a flavodoxin α methyltransferase: AMP L-threonine farnesyl uroporphyrinogen-III cyclohexadiene- BN1221_RS04370 triphosphate -4-methylthiazole hydroxymethylpyrimidine adenosylcobinamide- Metabolic Regulator Biosynthesis glucuronate 3-dehydro-L- 3-dehydro- reductase: deoxyglucarate D-galactonate degradation met ribonucleoside - -Kdo-(2-> -undecaprenyl L-alanine L-alanyl-γ-D- cofactor S-formylglutathione position 34 glutamate-α- RS15290 I: fabB 3-dehydroquinate ureidoglycolate dehydrogenase: a [pyruvate dehydrogenase E2 complex aceF6 semiquinone ditrans,octacis- a peptidoglycan arg asp cyclohexadiene- uracil reductase RibD: ribD GDP acetyltransferase: E2 protein] N -S- D-glucarate α BN1221_RS19020 a [glutamine Asp C-methyltransferase: 1-carboxylate an S-sulfanyl-[cysteine diphosphatase: kinase/ 5-methylbenzimidazole isomerase: L-gulonate BN1221_RS04280 6 triphosphate 4)- -KDO-(2- phosphate amidase glutamyl-meso-2,6- chaperone]-S- of a tRNA L-glutamate biotinyl-5'- RS14380 RS17385 diphosphate cob(I)yrinic acid a,c-diamide multifunctional hydroxyethylthiazole synthase: aroB (2S,3S)-2,3-dihydroxy- salicylate dehydrogenase: BN1221_RS18780 gulonate 2- aldolase: garL protein] N -dihydrolipoyl-L-lysinedihydrolipoyllysine- acetyl-CoA undecaprenyldiphospho- pentapeptide N-acetyl-D- a 3-oxoglutaryl- cobA 1-carboxylate desulfurase]-[disordered- 4-hydroxy-3- nudB 5-amino-6-(5-phospho- ribazoletransferase: cobS BN1221_RS17525 6-phosphate acetyldihydrolipoyl-L-lysine glucarate reductase >6)-lipid IV diaminopimeloyl- sulfanyl-L-cysteine synthetase]-O synthase: ispA synthase: menH adenosyltransferase: cobO transcriptional kinase: thiM phosphomethylpyrimidine uxaC dehydrogenase: 2-dehydro-3- D-galactonate N-acetyl-(N- A AmpD: ampD ala muramate adenylate synthase: menH octaprenylbenzoate 7,8- D-ribosylamino)uracil nicotinate-nucleotide-- 2,3-dihydrobenzoate ppGpp metabolism BN1221_RS20060 D-altronate residue dehydratase: 4 -(5'-adenylyl) [acp] methyl ester uroporphyrinogen-III form scaffold kinase: thiD mannosylglycerate [+ 2 isozymes] BN1221_RS06355 3-keto-L- acetylglucosaminyl)muramate a [protein]-S- D-alanine RS17930 geranyl 2-succinyl-5- dihydroneopterin regulator/nicotinamide- 4-methyl-5-(2- dimethylbenzimidazole 3-dehydroquinate [+ 2 isozymes] glucuronate deoxyglucarate acetyltransferase: gudD a guanine in DNA 2-succinyl-5- protein] complex 4-hydroxy-3- bifunctional adenosylcobinamide Coα-[α-(5-methoxybenzimidazolyl)]- 2,3-dihydro-2,3- biosynthesis I (R)-lactate gulonate-6- galactonate 5-dehydro-4- methyl-L-cysteine -L-tyrosine RS09520 3-oxoacyl- diphosphate C-methyltransferase: enolpyruvyl- 3'-phosphate nucleotide phosphooxyethyl) phosphoribosyltransferase: isomerase: 3-dehydro- altronate aldolase: garL aceF a peptidoglycan L-alanyl-γ-D- enolpyruvyl- octaprenylbenzoate diaminohydroxyphosphoribosylaminopyrimidine HMP-PP Coβ-adenosylcobamide 5'-phosphate type II 3- dihydroxybenzoate pppGpp phosphate dehydratase: deoxy-D-glucarate ACP cobA 6-hydroxy-3- adenylyltransferase/ thiazole cobT bifunctional GTP 3-phospho- GDP-α-D- acetyl-CoA formate uxaC L-gulonate dehydratase: tartronate dimer with glutamyl-meso-2,6- TauA RS20075 (2E,6E)- 5-hydroxylase: ubiH deaminase/5-amino-6-(5-phosphoribosylamino) bifunctional dehydroquinate dehydrogenase: dhbA decarboxylase dgoD reductase cyclohexene- 6-hydroxy-3- ribosylnicotinamide adenosylcobalamin/ diphosphokinase/ guanosine-5'- D-glycerate mannose (S)-malate BN1221_RS04275 pentapeptide diaminopimeloyl- farnesyl precorrin-2 3,4-dihydroxy- adenosylcobinamide 5-methoxy-6-methylbenzimidazolyl adenosylcobamide D-fructuronate semialdehyde FabG: fabG cyclohexene- uracil reductase RibD: ribD thiamine adenosylcobinamide- 5-methylbenzimidazole alpha-ribazole dehydratase: aroQ UlaD: ulaD 2-dehydro-3-deoxy- D-alanyl-D-alanine GspH 1-carboxylic- a [cysteine desulfurase]- kinase/adenosylcobinamide- kinase NadR: nadR biosynthesis from adenosylcobinamide-GDP 2,3-dihydroxybenzoate guanosine-3',5'-bis triphosphate,3'-diphosphate fumarate hydratase: citrate synthase: altronate 2-hydroxy-3- stem (meso- diphosphate 1-carboxylic- 5-all-trans- D-erythro-7,8- 5-amino-6-(5-phospho- phosphate GDP ribotide phosphate type I 3- phosphate bifunctional 3-keto-L-gulonate- D-galactonate RS20975 [+ 2 isozymes] acid synthase: S-sulfanyl-[disordered- chorismate phosphate phosphatase: pyrophosphate 3'- bifunctional GTP phosphatase: ppx BN1221_RS00450 fructuronate dehydratase: diaminopimelate synthase: ispA octaprenylbenzoate + BN1221_RS02700 acetyltransferase: acetaldehyde- 3-dehydro- oxopropionate acetyl-CoA pyruvate fermentation 2,5- a (3R)-3- menD acid synthase: form scaffold dihydroneopterin D-ribulose 5-phosphate D-ribitylamino)uracil NAD synthase: thiE BN1221_RS23055 dehydroquinate pyrophosphohydrolase: spoT diphosphokinase/ 6-phosphate BN1221_RS11850 2-dehydro-3- containing) guanylyltransferase: cobU 5-methoxy-6-methylbenzimidazole [+ 4 isozymes] citrate synthase: reductase: L-gulonate reductase: to acetate II dioxopentanoate HisJ RS21410 hydroxyglutaryl- (2E,6E)-farnesyl menD protein] complex bifunctional aminodeoxychorismate 5-amino-6-(5- adenosylcobinamide- α α dehydratase: aroD guanosine-3',5'-bis 2-O-(α-D- BN1221_RS14595 CoA/alcohol decarboxylase UlaD: 2-dehydro- deoxygalactonokinase: 2-succinyl-5- Co -[ -(5-methoxybenzimidazolyl) GTP diphosphokinase: relA BN1221_RS09310 CO H BN1221_RS01635 6-phosphate BN1221_RS12075 [acp] methyl ester diphosphate 2-succinyl-5- cysteine desulfurase: 3,4-dihydroxy- GDP nicotinate-nucleotide-- dehydrogenase: adhE 2 2 BN1221_RS09205 BN1221_RS17600 RS23245 sirohydrochlorin enolpyruvoyl- dihydroneopterin synthase phospho-D- ]-Coβ-adenosylcobamide pyrophosphate 3'- mannosyl)- fumarate 3-deoxy-D- ω chorismate adenosyl-cobinamide phosphate thiamine phosphate 3-dehydroshikimate [+ 2 isozymes] 3-keto-L- pyruvate 2503 a nascent a peptide with a [ThiI sulfur- a [glutamine poly-β-1,6- (2S,3S)-2,3- an N -(1- a (1->4)- 3-hydroxyacyl- enolpyruvoyl- BN1221_RS13370 3-methoxy-4- 2-butanone- ribazoletransferase: dimethylbenzimidazole adenine 3-phenyl-2- a [DNA]-3'- + a 5'-phospho- a [phospholipid]- RNase II poly-A a ribonucleoside phosphoenol a D-tyrosyl- an L-cysteinyl- RS03780 octaprenyl 6-hydroxy-3- aldolase/7,8- component 1: pabB ribitylamino)uracil 5,6-dimethylbenzimidazole pyrophosphohydrolase: spoT 3-phospho- citrate L-xylulose gluconate D-glycerate 2-dehydro-3- adenosylcobinamide a purine NAD H O (S)-ureidoglycolate α acetyl phosphate gulonate-6- pyruvate tyr peptidoglycan diphosphate 2 an N-terminal carrier protein]- cys synthetase]-O N-acetyl-D- dihydroxy-5- hydroxy-2- Tyr Pro -D-glucan ACP sirohydrochlorin 6-hydroxy-3- [+ 4 isozymes] hydroxy-5-all-trans dihydroneopterin 4-phosphate phosphatase cobS phosphoribosyltransferase: D-glycerate succinate D-mannonate 2-dehydro-3- deoxygalactonokinase: in 23S rRNA oxopropanoate hydroxyl [DNA] palmitoleate substrate mRNA diphosphate dADP pyruvate [tRNA ] [tRNA ] diphosphate cyclohexene- aminodeoxychorismate bifunctional shikimate 3-(4-hydroxyphenyl) acetaldehyde 5-phosphate ribonucleoside 4 cyclopropane fatty 1,4-alpha- chorismate an S-sulfanyl-[cysteine synthase: ribB thiamine- dehydrogenase/ phosphate pyruvate fermentation dehydrogenase 2-oxoglutarate (meso-DAP Xaa-L-proline L-cysteine -(5'-adenylyl) glucosamine malate/lactate/ oxohexanedioate ribonucleoside- oxopropyl) RS18650 FliD dehydratase synthase: ispB cobaltochelatase: 1-carboxylate cyclohexene- -octaprenylbenzoate epimerase: folB synthase component YigB: yigB nicotinate-nucleotide-- adenosylcobinamide cobT dehydrogenase: aroE pyruvate biosynthesis mannosyl-3- bifunctional deoxygluconokinase: BN1221_RS07575 5'-triphosphate lyase: ubiC desulfurase]-S- phosphate α α acetate kinase: mannonate decarboxylase L-ribulose-5- to acetate IV complex containing) -L-tyrosine acyl phospholipid ureidoglycolate diphosphate -[protein]- glucan FabZ: fabZ all-trans- BN1221_RS23100 2-succinyl-6- 1-carboxylate dimethylbenzimidazole Co -[ -(5- phosphoglycerate fumarate reductase aconitate hydratase bifunctional BN1221_RS06415 2-dehydro-3-deoxy- ribonuclease R: RS02565 sulfanyl-[disordered- 6-(hydroxymethyl) II: BN1221_RS05730 1-deoxy-L-glycero- kinase/adenosylcobinamide- kinase: thiL 5-methoxy-6-methylbenzimidazole quinate/shikimate GTP ppGpp BN1221_RS14600 dehydratase: UlaD: ulaD phosphate 3- bifunctional tRNA aspartate/ NAD- RdgB/HAM1 family synthase: dehydrogenase: L-arginine branching octaprenyl hydroxy-2, 4- 2-succinyl-6- ARP phosphoribosyltransferase: methylbenzimidazolyl)]- phosphatase- iron-sulfur subunit: 2/2-methylisocitrate D-galactonate dihydrolipoyllysine- Xaa-Pro cysteine poly-beta-1,6- 2-dehydro-3- reductase: D-tyrosyl- Cys- RS02845 bifunctional 3- 4-hydroxybenzoate cobalt- form scaffold -7,8-dihydropterin tetrulose 4-phosphate phosphate adenosylcobinamide-GDP ribotide phosphate dehydrogenase: ydiB tyr acetaldehyde- epimerase: 2-phospho- (adenosine(37)-C2) bifunctional dependent BN1221_RS18020 BN1221_RS11810 enzyme: hydroxy-2, 4- 4-amino-4- Coβ-adenosylcobamide BN1221_RS11005 uxuA KDGP pyruvate residue tyrosine/aromatic lytic transglycosylase non-canonical aminopeptidase: desulfurase bifunctional [glutamate- N-acetyl-D- BN1221_RS20060 deoxyglucarate nrdA nrdB pyruvate tRNA(Tyr) tRNA(Pro) hydroxydecanoyl- diphosphate sirohydrochlorin cyclohexadiene- 2-methoxy- cobT guanylyltransferase: cobU thiamine diphosphate related protein: dehydratase: acnB acetate CoA/alcohol 3-keto-L-gulonate- BN1221_RS06385 D-glycerate 6-phosphate -methyltransferase adenosylcobinamide DNA ligase exoribonuclease II: glgB cyclohexadiene- protein] complex 2-amino-4-hydroxy-6- deoxychorismate 5'-phosphate 5-hydroxybenzimidazolyl adenosylcobamide aspartate/ mannonate acetyltransferase: aminotransferase: purine NTP pepP cyclopropane fatty glucosamine malate/lactate/ aldolase: garL kinase protein deacylase: /Cys- ACP dehydratase/ cobalt-factor II C(20) 1-carboxylate 6-(all-trans- shikimate BN1221_RS19070 succinate aconitate hydratase dehydrogenase: adhE 6-phosphate TrmG/ribosomal kinase/ LigB: ligB domain-containing NifS: nifS -ammonia ligase]- class 1b a (1,6)-α-D- RS14795 FlgL hydroxymethyldihydropteridine 6,7-dimethyl-8- α superpathway of thiamine diphosphate biosynthesis I adenosylcobalamin/ biosynthesis from adenosylcobinamide-GDP adenosylcobinamide-GDP tyrosine/aromatic bifunctional GTP α [+ 2 isozymes] aceF D-galactarate BN1221_RS20705 pyrophosphatase: acyl phospholipid N-deacetylase BN1221_RS18145 PykF: pykF dtd 4-hydroxybenzoate synthase: menH 1-carboxylate aminodeoxychorismate -ribazole 5'-phosphate adenosylcobinamide-GDP 2-O-( -D- dehydratase: decarboxylase UlaD: bifunctional 2-dehydro-3-deoxy-6- RNA large subunit protein: leucyl [+ 4 isozymes] adenylyl-L-tyrosine ureidoglycolate 2-dehydro-3- ribonucleoside- deglycase tRNA(Cys) glucosyl-(1,4) CysA trans-2- -methyltransferase: octaprenyl)phenol diphosphokinase: folK ribityllumazine ribazoletransferase: cobS aminotransferase: diphosphokinase/ dehydrogenase/ AcnA: acnA L-ribulose 5- formate degradation II adenosylcobinamide- NAD- rdgB octaprenyltransferase: (1R,6R)-6-hydroxy- synthase: menH lyase: pabC alpha-ribazole shikimate kinase mannosyl)- ethanol uxuA BN1221_RS09205 4-hydroxy-2- phosphogalactonate acetyl-CoA aspartate/ BN1221_RS16150 aminopeptidase: phosphorylase/ synthase: PgaB: pgaB dehydrogenase: deoxyglucarate diphosphate pyruvate YajL: yajL deacylase -α-glucan RS09990 decenoyl-ACP BN1221_RS23095 (1R,6R)-6-hydroxy- 2-octaprenyl-6- (7,8-dihydropterin- synthase: ribE 5-hydroxybenzimidazole NaMN BN1221_RS11490 guanosine-3',5'-bis fumarate reductase acetyltransferase: methyltransferase phosphate RNase II BN1221_RS04370 2-succinylcyclohexa- phosphatase: AroL: aroL D-glycerate cis-aconitate phosphate oxoglutarate aldolase: tyrosine/aromatic dependent inorganic [glutamate-- BN1221_RS05130 BN1221_RS22235 kinase: pyk YbaK: ybaK isomerase: fabA 2-succinylcyclohexa- a [cysteine methoxyphenyl 6-yl)methyl cys pyrophosphate 3'- iron-sulfur: frdD frdC 2-dehydro-3- L-xylulose BN1221_RS17525 phosphate galactarate RlmN: trmG/rlmN guanylyltransferase: [+ 3 isozymes] pepA a [ThiI sulfur- a [phospholipid]-8- substrate with aldolase: garL reductase: 2,4-diene-1- adenosylcobinamide-GDP BN1221_RS23055 α α bifunctional GTP DNA ligase N-carbamoyl- Tyr cobalt-factor III desulfurase]-(S- 4-aminobenzoate Co -[ -(5-methoxy-6-methylbenzimidazolyl) [+ 2 isozymes] aspartate/ 5-phosphate L-ribulose-5- aldolase/2- L-idonate BN1221_RS17605 aminotransferase: diphosphatase: ala carrier protein]- ammonia-ligase] (2-hexylcyclopropyl) partially AMP nrdF nrdE D-tyrosine a tRNA 2,4-diene-1- hydroxylase: ubiH diphosphate Coα-[α-(5- pyrophosphohydrolase: spoT diphosphokinase/ BN1221_RS10005 bifunctional deoxy-D-gluconate [+ 2 isozymes] acetyltransferase: galactarate cobU LigA: ligA 2-oxoglycine no poly-A tail a 2'- a [protein]- RS19195 FlgK a (2E)-enoylglutaryl- 4-hydroxy-3- carboxylate sulfanyl) -[disordered- 2-methoxy-6-all 6,7-dimethyl-8-(1-D-ribityl)lumazine ribazoletransferase: cobS nicotinate-nucleotide-- ]-Coβ-adenosylcobamide 5'-phosphate tyrosine/aromatic phosphate 4- dehydro-3-deoxy- degradation BN1221_RS11490 BN1221_RS11990 adenylyltransferase: acetate (R)-lactate RS17800 2 frdA 2-dehydro-3- [+ 2 isozymes] dehydratase: S-sulfanyl- octanoate deacetylated poly- [acp] methyl ester carboxylate cysteine desulfurase: methylbenzimidazolyl)]- shikimate 3-phosphate GTP diphosphokinase: relA guanosine-3',5'-bis aconitate hydratase L-ribulose-5- BN1221_RS14595 2503 adenosyl- a mature a nascent a peptide with tartronate deoxyribonucleoside L-arginine octaprenylbenzoate o-succinylbenzoate trans-octaprenyl- dimethylbenzimidazole aminotransferase: nucleoside-diphosphate epimerase: phosphogluconate a 2-methyladenine a proteinogenic glnE β pyruvate pyruvate Pro CysT o-succinylbenzoate form scaffold dihydropteroate BN1221_RS13370 β adenosylcobalamin/alpha- Glycolysis deoxygluconokinase: phosphate 3- garD 5'-deoxyadenosine peptidoglycan peptidoglycan an N-terminal L-cysteine -1,6-N-acetyl- 5'-diphosphate dATP cys a tRNA synthase: menC 1,4-benzoquinol riboflavin synthase: Co -adenosylcobamide 3-(4- BN1221_RS20705 kinase: BN1221_RS13420 pyrophosphate 3'- 2/2-methylisocitrate BN1221_RS09195 aldolase: eda L-idonate acetyl-CoA formate 5-dehydro-4- in 23S rRNA met cobinamide 3-(4- amino acid semialdehyde enoyl-ACP UbiD family protein] complex synthase: folP adenosylcobalamin 5'-phosphate phosphoribosyltransferase: ribazole phosphatase: succinate BN1221_RS06415 D-glyceraldehyde acetyl phosphate D-glucosamine synthase: menC [+ 4 isozymes] 3-phosphoshikimate 1- hydroxyphenyl) pyrophosphohydrolase: spoT dehydratase: acnB epimerase: pyruvate phosphate a purine [DNA] NMN with (L-alanyl- (meso-DAP + L-proline reductase decarboxylase: o-succinylbenzoate bifunctional BN1221_RS18015 cobT [+ 3 isozymes] 3-phosphate deoxy-D-glucarate hydroxyphenyl) phe phosphate H an [L-cysteine BN1221_RS23055 carboxyvinyltransferase: glycolysis III (from glucose) BN1221_RS06385 phosphate ribonucleoside AMP γ-D-glutamyl- containing) with a [glutamine- cobalt-precorrin-3 synthase: menC o-succinylbenzoate demethylmenaquinone demethylmenaquinol- pyruvate GDP aconitate hydratase pyruvate pyruvate SecM KefB FabI: fabI BN1221_RS14310 7,8- adenosylcobalamin/alpha- desulfurase]-S- a [ThiS sulfur- Coα-[α-(5-methoxy-6-methyl- aroA KDGP D-xylulose acetyltransferase: acetate kinase: 5'-diphosphate meso-2,6- GlcNAc terminus synthetase]- Re/Si-specific synthase: menC riboflavin AcnA: acnA [+ 2 isozymes] 5-dehydro- ADP methyltransferase/2- 6 biosynthesis I ribazole phosphatase: carrier protein] β 5-phosphate + + a glutaryl-[acp] [+ 3 isozymes] 2-succinylbenzoate a [cysteine desulfurase]- dihydropteroate sulfanyl-L-cysteine 5-hydroxybenzimidazole benzimidazolyl)]-Co -adenosylcobamide 5-enolpyruvoyl- L-ribulose 5- D-gluconate BN1221_RS14595 BN1221_RS14600 diaminopimeloyl- L-tyrosine H NAD(P)(+) H methoxy-6-polyprenyl- all-trans- BN1221_RS23055 cysteine desulfurase: adenosylcobinamide-GDP D-glucopyranose methyl ester 2-succinylbenzoate [scaffold protein- bifunctional bifunctional ribotide phosphate shikimate 3-phosphate D-threo-isocitrate 2,5- D-alanine) transhydrogenase 2-octaprenylphenol 1,4-benzoquinol 1,4-dihydroxy- pyruvate fermentation bifunctional phosphate gluconate 5- o-succinylbenzoate- (2Fe-2S)] complex tetrahydrofolate hexaprenyl riboflavin kinase/ BN1221_RS13370 glucokinase: acetyl phosphate acetate dioxopentanoate tetrapeptide F0F1 ATP beta-ketoacyl- methylase UbiE: ubiE 2-naphthoate adenosylcobalamin to ethanol I 4-hydroxy-2- L-ribulose-5- dehydrogenase: H + H + RS17720 cobalt-precorrin-4 -CoA ligase: menE o-succinylbenzoate- synthase/ diphosphate FAD synthetase: ribF [+ 4 isozymes] adenosylcobinamide- chorismate NADP-dependent BN1221_RS07675 superpathway of acetate synthase RS22010 ACP synthase 6-methoxy-3- a [ThiI sulfur- a carboxy- oxoglutarate phosphate 4- idnO utilization and formation 4-(2'- -CoA ligase: menE dihydrofolate D-glyceraldehyde GDP synthase: aroC isocitrate acetate kinase: II: fabF methyl-2-all- pyruvate D-glucopyranose epimerase: a ring-opened 7- a [protein]-L- an unstable + + cobalt-precorrin-4 4-(2'- 1,4-dihydroxy- FMN carrier protein]-S- adenylated-[ThiS NAD glutathione- dehydrogenase: aldolase/2- a mature peptidoglycan an [HPr]- phosphoenol 4-amino-4- 3-benzyl-3,6 - a [protein chain a guanine 2445 a cis-delta19- a [phospholipid]- H FliI H carboxyphenyl)- synthase: folC 3-phosphate ribazoletransferase: cobS D-gluconate BN1221_RS14600 lipid IV (E. coli) an N-carbamoyl a nucleoside 5 a D-aspartyl- 34 beta-ketoacyl- 3-(all-trans a [co-chaperone]- trans-octaprenyl- AIR tyr 6-phosphate BN1221_RS09195 methylguanine α A acetoacetate succinyl-CoA acyl-carrier protein bis(cysteinylglycine) β an HmqF protein 37-methoxy-38- (S)-ureidoglycolate glutamate-O a cytidine lys RecA filament- methyltransferase: carboxyphenyl)- 2-naphthoate sulfanyl-L-cysteine sulfur-carrier protein] phosphorylation and glutaredoxin chorismate BN1221_RS19940 dehydro-3-deoxy- acetate (meso-diaminopimelate L-histidine pyruvate deoxy- -L- 5-hexenoate (R)- -lysine elongation factor decanoate in 23S rRNA oleate RNA asp ATP roseoflavin 4-oxobutyryl-CoA bifunctional 1-deoxy-D-xylulose- acetate--CoA D-amino acid triphosphate [tRNA ] Ile2 ACP synthase -octaprenyl) [scaffold protein- 1,4-benzoquinol 7,8-dihydrofolate polyprenyltransferase: transhydrogenation redox reactions glucose-6-phosphate phosphogluconate [+ 3 isozymes] gluconokinase: 2-oxoglutarate in DNA containing) arabinopyranosyl - 6-(hydroxymethyl) EF-P]-L-lysine 34 bifunctional methyl-C57:1-[acp] malate/lactate/ cyclopropane fatty -methyl-ester in tRNA DNA complex MscL BN1221_RS23120 4-oxobutyryl-CoA phosphomethylpyrimidine α α formate D-gluconate acetate cyclopropane fatty N-carbamoyl- 5'-phosphate DNA I: fabB benzene-1,2-diol 1,4- (2Fe-2S)] complex monoglutamate riboflavin kinase/ 5-phosphate 2-iminoacetate Co -[ -(5-hydroxybenzimidazolyl)]- 2-oxoglutarate idnK ligase: acs -diketopiperazine ureidoglycolate acyl phospholipid RseB 2-octaprenyl- BN1221_RS06035 + isomerase: aldolase: eda D-xylulose degradation acetate kinase: ditrans,octacis 23S rRNA acyl phospholipid D-amino-acid repair MurJ cobalt- dihydroxy-2- 1,4- FAD synthetase: ribF synthase ThiC: thiC synthase: synthase Coβ-adenosylcobamide 5'-phosphate NAD glutathione acetyltransferase: phosphoenolpyruvate- acyl CoA:acetate/ bifunctional 2- 3-methyl-6- BN1221_RS09965 5-phosphate [+ 2 isozymes] BN1221_RS14600 -undecaprenyl (guanine(2069)-N(7) synthase: dehydrogenase: synthase: hydrolase: DNA- chemotaxis D-tyrosyl- tRNA protein a 3-oxopimeloyl- precorrin-5A naphthoyl- dihydroxy-2- BN1221_RS01475 ThiH: thiH NAD(+) BN1221_RS17525 bifunctional DNA- lytic transglycosylase protein 3-ketoacid CoA bifunctional acyl- elongation bifunctional acyl- polyprenyl-6- methoxy-1,4- a thiocarboxylated- adenosylcobalamin/ pyruvate fermentation D-glyceraldehyde D-gluconate D-gluconate phosphate membrane )-methyltransferase BN1221_RS05130 BN1221_RS22235 BN1221_RS18020 BN1221_RS13690 directed RNA response tRNA(Tyr) lysidine(34) bifunctional RecO: [acp] methyl ester cobalt- CoA naphthoyl- demethylmenaquinol-6 FAD HMP-P kinase: nadK [+ 2 isozymes] F6P pyruvate formamidopyrimidine domain-containing phosphotransferase transferase: ACP--phospholipid factor P--(R) ACP--phospholipid hydroxyphenol benzoquinol 1-deoxy-D-xylulose [ThiS sulfur- alpha-ribazole gluconeogenesis I Carbohydrate Biosynthesis 3-phosphate gluconokinase: 6-phosphate acetyl phosphate acetyl-CoA RlmK/23S rRNA polymerase: riboflavin RS03655 CoA a [chaperone-ATP]- 2-iminoacetate 2-methyladeninyl adenosylcobamide + a reduced UDP-N-acetyl-D- to (S)-acetoin glycosylase/ protein: O-acyltransferase/ dipeptidase: -beta-lysine O-acyltransferase/ cyclopropane fatty malate/lactate/ cyclopropane fatty N-carbamoyl- regulator protein- deacylase: synthetase a stabilizedrecO 3-oxoacyl- precorrin 5A synthase: 5-phosphate NADP α glycogen biosynthesis I (from ADP-D-Glucose) PtsI: ptsI BN1221_RS12420 methylase/3- [co-chaperone]- hydroxylase: a 7,8-dihydrofolate bifunctional carrier protein] biosynthesis from adenosylcobinamide-GDP phosphatase: UDP- -D- idnK DNA-(apurinic BN1221_RS16150 long-chain-fatty- BN1221_RS08145 ligase: epmA long-chain-fatty- (guanine(2445)-N(2) ureidoglycolate acyl phospholipid rpoC rpoB glutamate dtd TilS: tilS kinase/FAD RS07955 RS10680 ACP hydrolase: (2E,6E)-farnesyl menB synthase: glutaredoxin glucosamine biosynthesis I 6-phosphofructokinase lipid IV(A) 4- acyl phospholipid D-amino-acid RecA filament- demethylubiquinol 3- ubiF hydroxymethylpyrimidine BN1221_RS23055 galactose acetyl-CoA formate pyruvate [+ 2 isozymes] phosphoenolpyruvate- 3-oxoacid CoA- )-methyltransferase dehydrogenase: synthase: [+ 2 isozymes] methylesterase: synthetase: cbiG diphosphate (2E,6E)-farnesyl menB [scaffold protein- Re/Si-specific (S)-malate II: pfkB D-gluconate or apyrimidinic [+ 4 isozymes] amino-4-deoxy-L- acid--ACP ligase: acid--ACP ligase: synthase: hydrolase: DNA complex reductase O-methyltransferase 1,4-dihydroxy-2- kinase/ thiazole synthase: α α glutaredoxin biosynthesis D-glucopyranose D-glucopyranose 6-phosphate acetolactate -protein transferase: RlmL: rlmKL ribF diphosphate (2Fe-2S)] complex 2-methyladenine Co -[ -(5-hydroxybenzimidazolyl) NAD(P)(+) phosphate site) lyase: mutM arabinosyltransferase: BN1221_RS11575 3-benzyl-3,6 - [a protein chain BN1221_RS11575 2 BN1221_RS18020 BN1221_RS20060 BN1221_RS05130 BN1221_RS21800 cheB 34 FabG: fabG UbiG: ubiG cobalt- octaprenyl naphthoyl-CoA 1,4-dihydroxy-2- 3-