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Chemicals and Obesity

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Chemicals and Obesity CHEMICALS AND OBESITY While diet and exercise are important factors in the obesity epidemic, an emerging body of science demonstrates that exposures to chemical obesogens may be important contributors. A number of chemicals known to disrupt hormones also appear to affect the size and number of fat cells or hormones that regulate appetite and metabolism. The U.S. is confronting the growing rate of obesity as a major building materials. Hundreds of chemicals are recognized as public health problem. One-third of American children, and hormone disrupters that impact the delicate hormone balance two-thirds of adults, are obese or overweight.1 The direct costs in the human body. Hormone disrupters are especially harmful of treating obesity alone are $190 billion per year,2 which might because, like hormones themselves, they can exert health be as high as 16.5 percent of national health care spending.3 impacts even at minute levels of exposure and exposures in the While diet and exercise are widely recognized as important womb can have lifelong impacts. factors in the obesity epidemic, there is an emerging body of science showing that exposures to chemical obesogens may be important contributors. Obesogens are chemical agents Hormone disruption that promote fat accumulation and alter feeding behaviors A number of chemicals known to disrupt hormones also appear through various mechanisms, and we are all exposed to them to be obesogens.4,5 A 2011 National Institute of Environmental every day. Health Sciences (NIEHS) expert workshop concluded that the scientific literature supports a link between certain environ- mental chemicals and increased risk for obesity as well as Type 2 diabetes.6 Chemicals can affect the size and number of fat Widespread exposure cells or the hormones that regulate appetite and metabolism. Widespread production and use of industrial chemicals in both They can also cause changes in gene expression, or epigenetic agriculture and consumer products results in daily exposure to 7 changes, which can have intergenerational impacts. Prenatal an array of chemicals that build up in the food chain or leach and early life exposures to chemical obesogens are especially into our food from packaging. We are also exposed to some impactful, as they may alter metabolism and development of of these same chemicals from other consumer products and Written by Kathleen Schuler, June 2013 2105 First Avenue South Minneapolis, Minnesota 55404 USA iatp.org fat cells over a lifetime, as illustrated by the work of Dr. Bruce Some of the chemicals to which humans are exposed on a Blumberg (University of California, Irvine) with organotins regular basis are persistent chemicals that accumulate in the (organic compounds containing a carbon to tin bond). food system and in the human body, even though many of them, like DDT, have been phased out of use. There is evidence that DDT exposure is associated with obesity. Exposure to DDT and oxychlordane was associated with increased body mass Obesogens old and new index and waist circumference.19 Maternal levels of DDE, a Blumberg first coined the term “obesogens” in 2006, after metabolite of DDT, were associated with increase in body mass he discovered the obesogenic effects of tributyltin (TBT), an 20 index (BMI) in adult female offspring. Similarly, in a study of organotin fungicide still used in wood preservatives and as Michigan mothers who consumed fish contaminated with an additive to polyvinyl chloride.8 He found that the offspring DDT, prenatal DDE levels were statistically and significantly of pregnant mice fed organotins were heavier than mice that 21 associated with increased weight and BMI of adult offspring. were not exposed. The exposed mice were predisposed to 22 Exposure to DDE was linked to elevated BMI in infancy and in make more and bigger fat cells and in utero exposures caused 23 three-year-olds. While DDT has been phased out of use in the permanent effects.9,10 TBT activated a receptor in the body U.S., some persistent and bio-accumulative chemicals known that regulates fat cells known as PPAR or peroxisome prolif- to have obesogenic effects are still in use, including bromi- erator-activated receptor. Chemical “imposters” can bind to nated flame retardants or PBDEs and perfluorinated chemicals. 11 the receptor and activate the program that makes fat cells. Other obesogens, including bisphenol A and phthalates, are 12,13,14 15 Chemicals that activate PPAR include tributyltin, DEHP short lived in the body, but are widely used in food packaging 16,17 and its metabolite MEHP. While studies of human exposure and other products, affording ubiquitous exposures. to TBT are rare, this research provides evidence of mechanisms for obesogenic effects now seen from scores of chemicals to which people are exposed every day.18 EXAMPLES OF CHEMICAL OBESOGENS Bisphenol A (BPA) Prenatal and early life exposures to bisphenol A, a chemical commonly used in food packaging, are linked with obesity. Bisphenol A (BPA) is a chemical component of polycarbonate plastic used in many food and drink containers and in epoxy resins used as coatings in food cans. The Centers for Disease Control (CDC) biomonitoring program has detected BPA in the urine of 93 percent of adults sampled.24 Scientists have measured BPA in the blood of pregnant women, in umbilical cord blood and in the placenta.25,26 Exposure levels in one study were comparable to those shown in animal studies to cause adverse effects on reproduction.27 BPA disrupts hormones in the human body and animal studies show that low-dose early life exposure is linked with reproductive and developmental problems, genetic damage28 and cancer.29,30,31 In humans, higher BPA levels in urine were associated with ovarian dysfunction,32 recurrent miscarriages,33 cardiovascular diagnoses, diabetes, obesity, abnormal concentrations of liver enzymes34 and reported heart disease.35 There is growing evidence from both animal and human studies of BPA’s obesogenic effects. Perinatal and postnatal exposure to BPA is used in metal can linings . CC image courtesy of beana_ BPA in drinking water was associated with increased mean body cheese via Flickr. weight36,37 and total cholesterol in mice.38 Exposure of pregnant mice to BPA was associated with insulin resistance in both the controls.40 Perinatal exposure to BPA followed by a normal diet mothers and their male pups.39 Mouse embryos exposed to BPA resulted in increased body weight, elevated insulin and impaired grew into significantly heavier pups compared with unexposed glucose tolerance in adult rat offspring. In the same study rats 2 fed a high-fat diet following perinatal exposure to BPA were disposed to severe metabolic syndrome.41 Regulation in the U.S. as of June 2013: None at federal level, but 12 states (CA, CT, DE, IL, Children and adolescents with higher urinary BPA concentra- ME, MD, MA, MN, NY, VT, WA, WI) have banned BPA 42 tions were more likely to be obese. Higher levels of urinary in baby bottles and cups. VT, CT, MN and ME bans BPA were linked to higher incidence of diabetes in adults43 also include baby food and formula containers. and higher BMI and waist circumference.44 Exposure to BPA at environmentally relevant doses can inhibit release of a hormone from fat cells that protects humans from metabolic syndrome45 and is associated with the conversion of connec- tive tissue cells to fat cells.46 Phthalates Phthalates are hormone-disrupting chemicals commonly found in plastics and fragranced personal care products.” Phthalates are plasticizers that people are exposed to daily through food, water, air and consumer products. Di-2-eth- ylhexyl phthalate (DEHP) is of particular concern, as it is a hormone disruptor and a possible human carcinogen, affecting the liver.47,48 Exposure is associated with liver and thyroid toxicity, reproductive abnormalities and adverse effects on the respiratory system, including asthma.49 The CDC biomonitoring program has identified metabolites of DEHP in nearly everyone tested. There is evidence that DEHP, a phthalate used in PVC, is an Some children’s shampoos contain phthalates. CC image courtesy of obesogen. Higher urinary phthalate metabolite concentrations thejbird via Flickr. in adult males were associated with increase waist circumfer- ence and insulin resistance.50 Similarly, urinary concentrations Regulation in the U.S. as of June 2013: of some phthalate metabolites were associated with higher Federal law bans some phthalates in toys and baby 51 BMI and waist circumference for adults. Children with higher products and preempts state laws regulating phthal- 52 DEHP levels were more likely to have higher body mass index. ates in these products. The phthalate MEHP activates metabolic sensors that regulate fat cells,53 similar to effects seen with organotins. PBDEs (polybrominated diphenyl ethers) Evidence of potential obesogenic effects from exposure to PBDE flame retardants is growing. PBDEs (polybrominated diphenyl ethers) are chemical flame retardants used in foam products, textiles, electrical equip- ment, building materials and transportation. PBDEs are persis- tent in the environment and bio accumulate in animals and humans. CDC biomonitoring studies find PBDEs in everyone tested. Animal studies confirm that PBDEs are toxic to devel- oping organisms, with adverse effects on the brain, reproduc- tive system and liver. They also disrupt thyroid function.54,55 Because PBDEs accumulate in fatty tissue, dietary intake of animal-based foods contributes to high body burdens of PBDEs in the U.S.56 Children have higher levels of these chemi- cals in their bodies due to both dietary exposure and exposure Polyurethane foam used in furniture may contain PBDEs. CC image through household dust.57,58 courtesy of Tom & Katrien via Flickr. 3 Evidence from both animal and human research points to PBDEs as potential obesogens. Rats exposed to PBDEs expe- Regulation in the U.S.
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