The Refugee Scholars Who Found Safety
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Warburg Effect(S)—A Biographical Sketch of Otto Warburg and His Impacts on Tumor Metabolism Angela M
Otto Cancer & Metabolism (2016) 4:5 DOI 10.1186/s40170-016-0145-9 REVIEW Open Access Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Abstract Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s–1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg’s reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
ETH Zurich Annual Report 2006
Research Collection Report ETH Zurich Annual Report 2006 Author(s): ETH Zurich Publication Date: 2007 Permanent Link: https://doi.org/10.3929/ethz-b-000299445 Rights / License: In Copyright - Non-Commercial Use Permitted This page was generated automatically upon download from the ETH Zurich Research Collection. For more information please consult the Terms of use. ETH Library www.ethz.ch ETH Zurich Annual report 2006 Annual report 2006 Contents ETH Zurich 3 Highlights 5 Foreword from the President 6 What motivates us 8 Research and Teaching 14 Corporate Communications In Focus: 25 Systems biology 26 Vision and reality Energy science 33 Environmentally conscious and capable Information technology 38 intelligent and networked Renata Cosby, Andreas Fiersbach, Katrin la Roi, Arturo La Science City 45 Vecchia, Martina Märki, Dr. Verena Schmid Bagdasarjanz High-tech with a thinker’s culture Figures and Facts 48 Design and layout: Inform. Agentur für visuelle Kommunikation AG, Zürich Photos, illustrations: Daniel Boschung; Ruth Erdt; Nathalie Guinard; Maurice Haas; Prof. Gramazio / Prof. Kohler, DFAB, D-ARCH, ETH Zürich; J. P. Li, CCA California College of the Arts, San Francisco; and others Print: NZZ Fretz AG Circulation: 1200 Cover photo: A research team led by Dr. Christian Baerlocher and Dr. Lynne McCusker from the Laboratory of Crystallography at ETH Zurich has succeeded in solving the structure of the zeolite IM-5. The Annual report can be obtained from: Though IM-5 was first synthesized ten years ago, its complex structure remained unclear until now. ETH Zurich, Mailing Department, [email protected] ETH Zurich ETH Zurich stands for world-class scientific expertise, research that improves industry and society, and the education of highly-qualified specialists. -
Journal BAS ^ Association of Jewish Refugees the Rescue of Refugee Scholars
VOLUME 9 NO.2 FEBRUARY 2009 journal BAS ^ Association of Jewish Refugees The rescue of refugee scholars eventy-five years ago, in 1933, Robbins on the spot. The AAC, which was the Academic Assistance Council, essentially mn from within the academic known from 1936 as the Society for community in Britain, then came into being the Protection of Science and very quickly. SLeaming, was founded. The AAC/SPSL was In May 1933, a letter signed by a list of a remarkable body that played a unique part leading figures in British university and in the rescue of scholars and scientists, intellectual life was published in The Times, mostly Jewish, who had been dismissed by proposing the establishment of an organi the Nazis from their posts at German and sation to rescue the careers and lives of Austrian universities and whose livelihoods, displaced academics. The Council's initial and lives, were endangered. declaration was signed by over 40 of Brit After the passing of the Gesetz zur ain's most eminent men of scholarship, Wiederherstellung des Bemfsbeamtentums including John Maynard Keynes, Gilbert of 7 April 1933, aimed at removing racially Murray, the Presidents of the Royal Society and politically undesirable persons from and the British Academy, and 9 Chancel the civil service, something like a quarter Esther Simpson OBE lors or Vice-Chancellors of universities and of the academic staff at German sciences), an extraordinary record of 7 Masters or Directors of colleges. The universities and research institutes were academic achievement. celebrated scientist Lord Rutherford became dismissed, of whom some 2,000, or about The two principal initiators of the AAC the AAC's first president. -
The Making of a Biochemist
book reviews disappearance of kuru as an important In the late 1920s, he looked into the effect TION episode in our understanding of the risks of light on the inhibition by carbon monox- A associated with this type of infectious ide of respiration in living cells. This work process. Informing the wider community of encompassed considerations of photo- these risks may lead to a more helpful debate chemical processes in terms of quantum about the public health policies required chemistry, and the use of the manometer, NOBEL FOUND to minimize the chances of another BSE photoelectric cell and spectroscope. From epidemic. Books such as this are useful in the shape of the curve obtained by plotting this context. the effectiveness of light against its wave- Colin L. Masters is in the Department of Pathology, length, it was possible to deduce the resem- 8 The University of Melbourne, Parkville, Victoria, blance between the respiratory ferment and 3052, Australia. haemins. Warburg was awarded the Nobel prize for physiology or medicine in 1931 for his recognition of the haemin-type nature of the respiratory ferment and its underlying The making principles. The development of Warburg’s theoreti- of a biochemist cal thinking and experimental procedures are Otto Warburgs Beitrag zur ably chronicled in Petra Werner’s introducto- Atmungstheorie: Das Problem der ry essay. Her book is the first volume of an Sauerstoffaktivierung* edition of Warburg’s correspondence Brilliant but flawed: Warburg tended to pettiness. by Petra Werner deposited in the Berlin–Brandenburg Aca- Basilisken-Presse: 1996. Pp. 390. DM136 demy of Sciences. Regrettably, the 143 pub- 1950). -
Nuclear Weapons Technology 101 for Policy Wonks Bruce T
NUCLEAR WEAPONS TECHNOLOGY FOR POLICY WONKS NUCLEAR WEAPONS TECHNOLOGY 101 FOR POLICY WONKS BRUCE T. GOODWIN BRUCE T. GOODWIN BRUCE T. Center for Global Security Research Lawrence Livermore National Laboratory August 2021 NUCLEAR WEAPONS TECHNOLOGY 101 FOR POLICY WONKS BRUCE T. GOODWIN Center for Global Security Research Lawrence Livermore National Laboratory August 2021 NUCLEAR WEAPONS TECHNOLOGY 101 FOR POLICY WONKS | 1 This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory in part under Contract W-7405-Eng-48 and in part under Contract DE-AC52-07NA27344. The views and opinions of the author expressed herein do not necessarily state or reflect those of the United States government or Lawrence Livermore National Security, LLC. ISBN-978-1-952565-11-3 LCCN-2021907474 LLNL-MI-823628 TID-61681 2 | BRUCE T. GOODWIN Table of Contents About the Author. 2 Introduction . .3 The Revolution in Physics That Led to the Bomb . 4 The Nuclear Arms Race Begins. 6 Fission and Fusion are "Natural" Processes . 7 The Basics of the Operation of Nuclear Explosives. 8 The Atom . .9 Isotopes . .9 Half-life . 10 Fission . 10 Chain Reaction . 11 Critical Mass . 11 Fusion . 14 Types of Nuclear Weapons . 16 Finally, How Nuclear Weapons Work . 19 Fission Explosives . 19 Fusion Explosives . 22 Staged Thermonuclear Explosives: the H-bomb . 23 The Modern, Miniature Hydrogen Bomb . 25 Intrinsically Safe Nuclear Weapons . 32 Underground Testing . 35 The End of Nuclear Testing and the Advent of Science-Based Stockpile Stewardship . 39 Stockpile Stewardship Today . 41 Appendix 1: The Nuclear Weapons Complex . -
Illustrations from the Wellcome Institute Library the Chain Papers*
Medical History, 1983, 27:434-435 ILLUSTRATIONS FROM THE WELLCOME INSTITUTE LIBRARY THE CHAIN PAPERS* THE three men who shared the Nobel Prize in October 1945 for their work on penicillin could scarcely have differed more in their backgrounds and characters. Fleming was sixty-four years old by then; the son of a Scottish farmer, he was a retiring man, not given to conversation. By contrast, Florey, then aged forty-seven, was the son of a wealthy Australian boot and shoe manufacturer; aggressively ambitious, his achievements and intellect were later to secure him the Presidency of the Royal Society. Then there was Chain - a mere thirty-nine years old - a Jewish refugee of Russian origin, who still had major work on penicillin ahead of him; his ambition was mixed with an independence and volubility that was to lead him into conflict with the scientific/medical establishment. Fleming has been the subject of many biographies, mostly hagiographical. Florey's role in the penicillin story was recently reassessed in Gwyn Macfarlane's excellent Howard Florey. The making ofa great scientist (Oxford University Press, 1979). Sir Ernst Boris Chain died in 1979, and his biography is being written by Ronald W. Clark. This, together with future research on Chain's papers, will enable a fuller assessment to be made of the role and character of the youngest of the three scientists. The Chain papers, recently given by Lady Chain to the Contemporary Medical Archives Centre, form an extensive collection of some sixty-nine boxes, comprising material from Chain's personal and professional life. -
Gadol Beyisrael Hagaon Hakadosh Harav Chaim Michoel Dov
Eved Hashem – Gadol BeYisrael HaGaon HaKadosh HaRav Chaim Michoel Dov Weissmandel ZTVK "L (4. Cheshvan 5664/ 25. Oktober 1903, Debrecen, Osztrák–Magyar Monarchia – 6 Kislev 5718/ 29. November 1957, Mount Kisco, New York) Евед ХаШем – Гадоль БеИсраэль ХаГаон ХаКадош ХаРав Хаим-Михаэль-Дов Вайсмандель; Klenot medzi Klal Yisroel, Veľký Muž, Bojovník, Veľký Tzaddik, vynikajúci Talmid Chacham. Takýto človek príde na svet iba raz za pár storočí. „Je to Hrdina všetkých Židovských generácií – ale aj pre každého, kto potrebuje príklad odvážneho človeka, aby sa pozrel, kedy je potrebná pomoc pre tých, ktorí sú prenasledovaní a ohrození zničením v dnešnom svete.“ HaRav Chaim Michoel Dov Weissmandel ZTVK "L, je najväčší Hrdina obdobia Holokaustu. Jeho nadľudské úsilie o záchranu tisícov ľudí od smrti, ale tiež pokúsiť sa zastaviť Holokaust v priebehu vojny predstavuje jeden z najpozoruhodnejších príkladov Židovskej histórie úplného odhodlania a obete za účelom záchrany Židov. Nesnažil sa zachrániť iba niektorých Židov, ale všetkých. Ctil a bojoval za každý Židovský život a smútil za každou dušou, ktorú nemohol zachrániť. Nadľudské úsilie Rebeho Michoela Ber Weissmandla oddialilo deportácie viac ako 30 000 Židov na Slovensku o dva roky. Zohral vedúcu úlohu pri záchrane tisícov životov v Maďarsku, keď neúnavne pracoval na zverejňovaní „Osvienčimských protokolov“ o nacistických krutostiach a genocíde, aby „prebudil“ medzinárodné spoločenstvo. V konečnom dôsledku to ukončilo deportácie v Maďarsku a ušetrilo desiatky tisíc životov maďarských Židov. Reb Michoel Ber Weissmandel bol absolútne nebojácny. Avšak, jeho nebojácnosť sa nenarodila z odvahy, ale zo strachu ... neba. Každý deň, až do svojej smrti ho ťažil smútok pre milióny, ktorí nemohli byť spasení. 1 „Prosím, seriózne študujte Tóru,“ povedal HaRav Chaim Michoel Dov Weissmandel ZTVK "L svojim študentom, "spomína Rav Spitzer. -
Molecular Gastronomy
Mel’s Lesson Only for teaching purposes Science and Cooking • What does a Scientist and a Chef have in common? In cooking, it’s the synthesis (combining elements to make a One of the similarities between whole) of a meal or dining being a chef and a scientist is experience from a set of ingredients the method of creating an idea using known methods of cooking and getting results. In science, it’s the synthesis of an experiment using defined materials (lab rats, telescopes, In both science and cooking, you chemicals in a test tube) with take known ingredients and use a scientific equipment to obtain common set of techniques to get data about how something works. results. Scientist vs Chef Career Paths • Molecular gastronomy is a subdiscipline (A field of study Molecular or work that is related to one aspect, but not the whole, of a broader field of study or work) of food science that Gastronomy investigates the physical and chemical transformations of ingredients that occur in cooking. It’s program includes three areas, as cooking was recognized to have three components: social, artistic, and technical. Molecular cuisine is a modern style of cooking and takes advantage of many technical innovations from the scientific disciplines. Examples of Molecular Gastronomy History of Molecular Gastronomy • The scientific discipline — which was introduced under the name molecular and physical gastronomy was later shortened to molecular gastronomy . • Established in 1988 by Hervé This (top photo), a physical chemist, and Nicholas Kurti (bottom photo) , a former professor of physics at the University of Oxford. -
One Hundred Years of Chemical Warfare: Research
Bretislav Friedrich · Dieter Hoffmann Jürgen Renn · Florian Schmaltz · Martin Wolf Editors One Hundred Years of Chemical Warfare: Research, Deployment, Consequences One Hundred Years of Chemical Warfare: Research, Deployment, Consequences Bretislav Friedrich • Dieter Hoffmann Jürgen Renn • Florian Schmaltz Martin Wolf Editors One Hundred Years of Chemical Warfare: Research, Deployment, Consequences Editors Bretislav Friedrich Florian Schmaltz Fritz Haber Institute of the Max Planck Max Planck Institute for the History of Society Science Berlin Berlin Germany Germany Dieter Hoffmann Martin Wolf Max Planck Institute for the History of Fritz Haber Institute of the Max Planck Science Society Berlin Berlin Germany Germany Jürgen Renn Max Planck Institute for the History of Science Berlin Germany ISBN 978-3-319-51663-9 ISBN 978-3-319-51664-6 (eBook) DOI 10.1007/978-3-319-51664-6 Library of Congress Control Number: 2017941064 © The Editor(s) (if applicable) and The Author(s) 2017. This book is an open access publication. Open Access This book is licensed under the terms of the Creative Commons Attribution-NonCommercial 2.5 International License (http://creativecommons.org/licenses/by-nc/2.5/), which permits any noncom- mercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. -
Isaacashovb BOOKOF \SCIEI\CEN
IsaacAshovb BOOKOF \SCIEI\CEN Editedby IsaacAsimou andlason A. Shulman A BLUE CLIFF EDITIONS BOOK - XN WeidenfeUWtf:; Copyright @ 1988by Blue Cliff Editions, Inc. All rights reserved.No reproductionof this book in whole or in part or in any form may be madewithout written authorizationof the copyright owner. Publishedby Weidenfeld& Nicolson, New York A Division of Vheatland Corporation 10 East53rd Street New York, NY 10022 Publishedin Canadaby GeneralPublishing Company, Ltd. Due to limitationsof space,permissions appear on Page 337. Library of CongressCataloging-in-Publication Data IsaacAsimov's book of scienceand nature quotations / editedby Isaac Asimov andJasonA. Shulman.-lst ed. p. cm. 'A Blue Cliff editionsbook. " Includesindex. rsBN 1-555-84111-2 1. Science-Quotations,maxims, etc. I. Asimov,lsaac, I92A- II. Shulman,Jason. Iil. Title: Book of scienceand nature quotations. Q173.r831983 87-22489 5oo-dc19 cIP Manufacturedin the United Statesof America Designedby lrving PerkinsAssociates, Inc. First Edition 1098765432r FOR MY DAUGHTER ARIANA ELIZABETH: May the Seasstay DrE andthe Skystay HW May yourHeait ttoy Oput andBeauty fiU yourEyt, J. A. S. Acklrowledg*ents THts BooK could not havebeen createdwithout a number of peopleI would like to acknowledg. here: A*y Appleby, ashead researcher,was responsiblefor gathering mosr of the raw material used in the book. Her skill in findirg quotarions for every subject I could conceive of (and some she inventedl) was truly amtzing. This proJectcould not have gotten out of its infancy without her care and work. SusanWalker not only added many of the quotations, but did much of the original researchin finding quotations from news stories and scientific abstracts alike. -
J. G. WEISEND II G. TERENCE MEADEN a Biography of a Great
Springer Biographies Going for Cold A Biography of a Great Physicist, Kurt Mendelssohn J. G. WEISEND II G. TERENCE MEADEN Springer Biographies The books published in the Springer Biographies tell of the life and work of scholars, innovators, and pioneers in all fields of learning and throughout the ages. Prominent scientists and philosophers will feature, but so too will lesser known personalities whose significant contributions deserve greater recognition and whose remarkable life stories will stir and motivate readers. Authored by historians and other academic writers, the volumes describe and analyse the main achievements of their subjects in manner accessible to nonspecialists, interweaving these with salient aspects of the protagonists’ personal lives. Autobiographies and memoirs also fall into the scope of the series. More information about this series at http://www.springer.com/series/13617 J. G. Weisend II • G. Terence Meaden Going for Cold A Biography of a Great Physicist, Kurt Mendelssohn J. G. Weisend II G. Terence Meaden Accelerator Division St Peter’s College European Spallation Source University of Oxford, UK Lund, Sweden ISSN 2365-0613 ISSN 2365-0621 (electronic) Springer Biographies ISBN 978-3-030-61198-9 ISBN 978-3-030-61199-6 (eBook) https://doi.org/10.1007/978-3-030-61199-6 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.