DOCSLIB.ORG

Translation Clinical Im

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Translation Clinical Im Translational Science: From Basic to Clinical Immunology and Allergy 28TH SYMPOSIUM Collegium Internationale Allergologicum Translational Science: From Basic to Ischia Clinical Immunology and Allergy ISCHIA, 25-30 APRIL 2010 Final Program 28th Symposium of the Collegium Internationale Allergologicum 25-30 APRIL 2010 Ischia, Italy www.ciaweb.org Table of Contents: Welcome Letter . .1 Alain L. de Weck Travel Grant Recipients . .2 General Information . 3–4 Social Events . .5 Optional Excursions . 6 Lacco Ameno Map . .7 Program-at-a-Glance . 8–9 Schedule of Events . .10–24 Abstracts . .25–104 Speaker and Chair Index . .105–107 Supporters . Back Cover TRANSLatiONAL SCIENCE: FROM Basic TO CLINicaL IMMUNOLOGY AND ALLERGY President Dear Colleagues, Gianni Marone It is with great pleasure that we welcome you to the 28th Symposium of the Vice President/ Collegium Internationale Allergologicum on Translational Science: From Basic to Past Secretary General Clinical Immunology and Allergy from 25-30 April 2010 in Ischia, Italy. Stephen Galli The purpose of the meeting is to bring translational scientists, clinical immunologists and allergists together to foster interdisciplinary approaches to Secretary General understand and treat immune-based disorders. Stephen Holgate As in previous years, the majority of the scientific program will be given over to Past President free communications that will be presented either as oral abstract presentations Johannes Ring or as poster discussions. The Collegium’s unique organizational structure and membership guidelines ensure that the science presented at the biennial Council Members symposia of the Collegium is not only important, but contains many late-breaking Mübeccel Akdis developments. Bruce Bochner Sven-Erik Dahlén We believe that the venue we have chosen to accommodate scientists and Fatima Ferreira accompanying persons follows the traditions and style that characterize the Jean Marshall meetings of the Collegium. Ischia is a truly inspirational island to visit from a Hirohisa Saito historical perspective as well as in regards to social events. Its rich culture Richard Stevens reflects its exciting past. Known as the “Green Island” for its abundance of woods Ronald van Ree and gardens, it was the first site in Italy to be colonized by the Greeks, “Magna Grecia.” The Greeks were attracted to the island by the many hot springs, whose Symposium Organizers healing properties still attract visitors worldwide. The Archeological Museum and Gianni Marone Excavations of Pithecusae are also just across the road from the venue. Massimo Triggiani On behalf of the Collegium Council Members, thank you for attending the 28th Symposium in Ischia! From the beginning, the Collegium was intended to be an exclusive group of friends pursuing excellence in research in a spirit of open intellectual exchange at meetings held in interesting and stimulating locations. We will again strive to fulfill this vision over the next week in Ischia. Yours sincerely, Executive Secretariat 555 East Wells Street Gianni Marone, MD FRCP Massimo Triggiani, MD PhD Suite 1100 President and Symposium Organizer Symposium Organizer Milwaukee, WI 53202 United States Tel: +1 414 918 3018 Fax: + 1 414 276 3349 [email protected] www.ciaweb.org 28th Symposium of the Collegium Internationale Allergologicum • 25-30 APRIL 2010 • Ischia 1 Alain L. de Weck Travel Grant Recipients For the first time, Alain L. de Weck Travel Grants have been awarded to young scientists that are presenting an abstract during the meeting. Each applicant was asked to provide a short letter of application, a copy of their abstract, a letter of recommendation from a current member of the Collegium and a copy of their Curriculum Vitae. Waived registration and a travel grant were awarded to the following attendees: Moran Elishmereni, Israel Angela Simpson, United Kingdom Stefan Feichtner, Austria Krisztina Szalai, Hungary Mitchell Grayson, United States Meri Tulic, Australia Simon Hogan, United States Luca Vangelista, Italy Rosetta Pedotti, Italy Michael Wallner, Austria Catherine Ptaschinski, Australia Hilary Whitworth, United Kingdom Travel Grant Recipients will be awarded with a certificate presented by Professor Alain L. de Weck during the Gala Dinner on 29 April 2010. The Collegium would like to thank the members who contributed to the Alain L. de Weck Travel Grant Fund (included in the membership renewal form) and the following companies: CSL Behring, Italy Indoor Biotechnologies 2 TRANSLatiONAL SCIENCE: FROM Basic TO CLINicaL IMMUNOLOGY AND ALLERGY General Information The 28th Symposium of the Collegium is held on the Hospitality Desk beautiful island of Ischia, located in the Bay of Naples, The Hospitality Desk is located in the lobby of the Regina 10 km off the western coast of Italy. Isabella Hotel. Delegates and accompanying persons will be able to sign up for excursions and ask for advice Ischia, historically called Pithecusae, has been colonized regarding activities in Ischia. by the Greeks, Romans, Saracens, Turks, and Aragonese; all of whom were interested in its excellent strategic Hours: position as well as its therapeutic hot-spring waters Monday, 26 April 8:00 – 12:00 and of course its attractive landscape. The result of all Wednesday, 28 April 7:00 – 11:00 this varied history can be seen in the ruins of various Thursday, 29 April 7:00 – 11:00 outposts, towers, and “tufa” rock shelters hidden all over the island. Language The official language of the 28th Symposium is English, Ischia, the “Green Island,” is extraordinary because and the official language of Ischia is Italian. English and it offers nature, culture, history and myth within a German are also widely spoken on the island. framework of breathtaking landscape and picturesque architecture. Lunches Airport Transfers Buffet-style lunches will be served in the Regina Isabella Restaurant during the following times: Transfers to and from the Naples Airport or the Naples Central Train Station are included in the registration Monday, 26 April 13:30 – 14:45 fee. Please confirm your departure pick-up time at the Wednesday, 28 April 13:15 – 14:30 Registration Desk located in the Angelo Rizzoli Conference Thursday, 29 April 13:00 – 14:15 Centre (ARCC). Lunch is included in the registration fee for delegates, accompanying persons and children. CME The 28th Symposium of the Collegium Internationale Oral Abstract Sessions Allergologicum will offer Continuing Medical Education Oral Abstract Sessions will take place on 26, 27, 28, 29 (CME) credits through the European Accreditation and 30 April. All Oral Abstract Sessions will take place Council for Continuing Medical Education (EACCME). in the Angelo Rizzoli Conference Centre (ARCC), which EACCME credits are recognized by the American Medical is directly across the Santa Restituta Square from the Association (AMA) toward the Physician’s Recognition headquarter hotel, the Regina Isabella. Award (PRA). To convert EACCME to AMA PRA category 1 credit, contact the AMA. All Oral Abstract Session presenters will be given 12 minutes to speak and 5 minutes for question and In order to receive your CME certificate by email, please answer. It is the responsibility of the chairpersons to fill out the CME Self-Reporter Form located in your keep the session on time. registration packet and return it to the Registration Desk in the Angelo Rizzoli Conference Centre (ARCC). Poster Sessions Poster Sessions will take place on 26, 28 and 29 April in Coffee Breaks the Gallery of Posters, which acts as the walk-way to the Coffee breaks are included in the registration fee for Angelo Rizzoli Conference Centre (ARCC). An assortment delegates and will be served daily. Coffee will be served of wine, cheese and other refreshments will be served. outside the Angelo Rizzoli Conference Centre (ARCC) and Poster presenters will stand next to their posters in the Gallery of Posters; please check the Schedule of during the session and be available for questions and Events for exact times. discussion. Authors should set posters on Monday, 26 April 2010 before 17:00. Currency The currency used in Ischia is the Euro. There are ATMs, Proceedings or Bancomats, widely available for cash withdrawal. Papers from the 28th Symposium will be published by Credit cards are also accepted at most hotels, Pacini Editore. restaurants and shops. Online submission is now open at Electricity http://mc.manuscriptcentral.com/cia2010. The electrical current in Italy is AC - the cycle is 50Hz Deadline for Submission: 30 June 2010 220V. The European plug with round prongs is used. Length of Manuscript Evaluations Oral presentations: 3 printed pages. This is equivalent Evaluation forms are included in the registration packet. to approximately 6.0 double spaced manuscript pages, Please fill out your form and return it to the Registration including tables, illustrations and references. Desk in the Angelo Rizzoli Conference Centre (ARCC). Poster presentations: 2 printed pages. This is equivalent to approximately 4.0 double-spaced manuscript pages, including tables, illustrations and references. Please note that per figure and table, 0.5 printed page has to be calculated. 28th Symposium of the Collegium Internationale Allergologicum • 25-30 APRIL 2010 • Ischia 3 General Information Registration The registration fee for accompanying persons and The Registration Desk is located in the Angelo Rizzoli children includes: Conference Centre (ARCC) on all days except Sunday, Airport Transfer on Arrival 25 April, when it is
Load more

Recommended publications
  • Deutsche Gesellschaft Für Experimentelle Und Klinische Pharmakologie Und Toxikologie E.V
    Naunyn-Schmiedeberg´s Arch Pharmacol (2013 ) 386 (Suppl 1):S1–S104 D OI 10.1007/s00210-013-0832-9 Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. Abstracts of the 79 th Annual Meeting March 5 – 7, 2013 Halle/Saale, Germany This supplement was not sponsored by outside commercial interests. It was funded entirely by the publisher. 123 S2 S3 001 003 Multitarget approach in the treatment of gastroesophagel reflux disease – Nucleoside Diphosphate Kinase B is a Novel Receptor-independent Activator of comparison of a proton-pump inhibitor with STW 5 G-protein Signaling in Clinical and Experimental Atrial Fibrillation Abdel-Aziz H.1,2, Khayyal M. T.3, Kelber O.2, Weiser D.2, Ulrich-Merzenich G.4 Abu-Taha I.1, Voigt N.1, Nattel S.2, Wieland T.3, Dobrev D.1 1Inst. of Pharmaceutical & Medicinal Chemistry, University of Münster Pharmacology, 1Universität Duisburg-Essen Institut für Pharmakologie, Hufelandstr. 55, 45122 Essen, Hittorfstr 58-62, 48149 Münster, Germany Germany 2Steigerwald Arzneimittelwerk Wissenschaft, Havelstr 5, 64295 Darmstadt, Germany 2McGill University Montreal Heart Institute, 3655 Promenade Sir-William-Osler, Montréal 3Faculty of Pharmacy, Cairo University Pharmacology, Cairo Egypt Québec H3G 1Y6, Canada 4Medizinische Poliklinik, University of Bonn, Wilhelmstr. 35-37, 53111 Bonn, Germany 3Medizinische Fakultät Mannheim der Universität Heidelberg Institutes für Experimentelle und Klinische Pharmakologie und Toxikologie, Maybachstr. 14, 68169 Gastroesophageal reflux disease (GERD) was the most common GI-diagnosis (8.9 Mannheim, Germany million visits) in the US in 2012 (1). Proton pump inhibitors (PPI) are presently the mainstay of therapy, but in up to 40% of the patients complete symptom control fails.
    [Show full text]
  • UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI Programa De Pós Graduação Em Ciência Florestal
    UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI Programa de Pós Graduação em Ciência Florestal Any Caroliny Pinto Rodrigues PERFIL DE EXPRESSÃO GÊNICA EM HÍBRIDOS DE Eucalyptus grandis x Eucalyptus urophylla AFETADOS PELO DISTÚRBIO FISIOLÓGICO DO EUCALIPTO (DFE) Diamantina 2020 Any Caroliny Pinto Rodrigues PERFIL DE EXPRESSÃO GÊNICA EM HÍBRIDOS DE Eucalyptus grandis x Eucalyptus urophylla AFETADOS PELO DISTÚRBIO FISIOLÓGICO DO EUCALIPTO (DFE) Tese apresentada à Universidade Federal dos Vales do Jequitinhonha e Mucuri, como parte das exigências do Programa de Pós Graduação em Ciência Florestal, área de concentração em Recursos Florestais, para obtenção do título de “Doutor”. Orientador: Prof. Dr. Marcelo Luiz de Laia Diamantina 2020 Aos meus pais e ao meu irmão por tudo que representam em minha vida e, de maneira mais especial, pelos últimos meses! Dedico com amor e gratidão! AGRADECIMENTOS Agradeço a Deus por ter sempre iluminado e guiado o meu caminho, por ter me dado fé e coragem para seguir a caminhada. Aos meus pais, Marly e Joaquim, os grandes mestres da minha vida! Agradeço o amor, apoio, incentivo e confiança incondicionais. Ao meu irmão, Thiago, que é o meu companheiro, cúmplice e melhor amigo. Agradeço por tornar sempre os meus dias mais alegres e por ter sido força quando eu mais precisei. À minha cunhada, por todo o suporte, força, ajuda e carinho que foram essenciais. A toda a minha família, em especial meus tios Marley, Flávio, Jorge e Mara, que são minha grande fonte de inspiração. A meus eternos amigos Laís (Grazy) e Luiz Paulo (Peré) que foram e são verdadeiros anjos em minha vida.
    [Show full text]
  • Intégration Des Modèles in Vitro Dans La Stratégie D'évaluation De La
    Intégration des modèles in vitro dans la stratégie d’évaluation de la sensibilisation cutanée : 2018SACLS003 Thèse de doctorat de l'Université Paris-Saclay NNT préparée à l’Université Paris-Sud École doctorale n°569 Innovation thérapeutique : du fondamental à l'appliqué Spécialité de doctorat: Immunotoxicologie Thèse présentée et soutenue à Chatenay-Malabry, le 26 Janvier 2018, par Elodie Clouet Composition du Jury : Dr. Bernard Maillère Président Directeur de Recherche, CEA (Immunochimie de la réponse immunitaire cellulaire) Pr. Armelle Baeza Rapporteur Professeur des Universités, Paris Diderot (BFA UMR CNRS 8251) Dr. Patricia Rousselle Rapporteur Directeur de Recherche, IBCP Lyon (FRE 3310, CNRS) Dr. Elena Giménez-Arnau Examinateur Chargé de Recherche, Université de Strasbourg (UMR 7177) Dr. Hervé Groux Examinateur Directeur de recherche, Immunosearch Pr. Saadia Kerdine-Römer Directrice de thèse Professeur des Universités, Université Paris-Sud (INSERM UMR-S 996) Dr. Pierre-Jacques Ferret Co-Encadrant Directeur de la Toxicologie et de la Cosmétovigilance, Pierre Fabre SOMMAIRE LISTE DES FIGURES .................................................................................................................................. 3 LISTE DES TABLEAUX ............................................................................................................................... 5 LISTE DES ABREVIATIONS ....................................................................................................................... 6 AVANT-PROPOS .....................................................................................................................................
    [Show full text]
  • Untersuchungen Zur Regulation Der Polyphenolbiosynthese in Der Erdbeerfrucht (Fragaria  Ananassa) Mittels Metabolite Profiling
    TECHNISCHE UNIVERSITÄT MÜNCHEN Fachgebiet Biotechnologie der Naturstoffe Untersuchungen zur Regulation der Polyphenolbiosynthese in der Erdbeerfrucht (Fragaria ananassa) mittels Metabolite Profiling Ludwig F. M. Ring Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt der Technischen Universität München zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigten Dissertation. Vorsitzende: Univ.-Prof. Dr. B. Poppenberger Prüfer der Dissertation: 1. Univ.-Prof. Dr. W. Schwab 2. Univ.-Prof. Dr. Th. Hofmann 3. Univ.-Prof. Dr. D. R. Treutter Die Dissertation wurde am 17.06.2013 bei der Technischen Universität München eingereicht und durch die Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt am 22.10.2013 angenommen. „… and all the pieces matter“ Lester Freamon, 2002 meiner Familie Danksagung I Danksagung Meinem Doktorvater Prof. Dr. Wilfried Schwab gilt mein besonderer Dank für die Überlassung des Themas und die Möglichkeit an seinem Fachgebiet zu promovieren. Außerdem danke ich ihm für seine immerwährende Unterstützung und seinen ausstrahlenden Optimismus. Bei Prof. Dr. Brigitte Poppenberger, Prof. Dr. Thomas Hofmann und Prof. Dr. Dieter Treutter bedanke ich mich für die Mitarbeit in der Prüfungskommission. Allen Kooperationspartnern des FraGenomics-Projekts, insbesondere Prof. Dr. Juan Muñoz- Blanco, Dr. Beatrice Denoyes-Rothan und Dr. Amparo Monfort, möchte ich für die gute Zusammenarbeit und die fruchtbaren Diskussionen bei den Projekttreffen danken. Prof. Dr. Victoriano Valpuesta danke ich sehr für die Möglichkeit meine Arbeiten zur Proteinanalytik am Department für Molekularbiologie und Biochemie der Universität Málaga durchführen zu können. Seinem gesamten Arbeitskreis danke ich für die herzliche Aufnahme! Gracias a todos los miembros del grupo! Además, les agradesco a Dra.
    [Show full text]
  • NSF Engineering Research Center for Biorenewable Chemicals, Third Year Renewal Proposal, Volume II NSF Engineering Research Center for Biorenewable Chemicals
    NSF Engineering Research Center for Biorenewable Center for Biorenewable Chemicals Annual Reports Chemicals 4-7-2011 NSF Engineering Research Center for Biorenewable Chemicals, Third Year Renewal Proposal, Volume II NSF Engineering Research Center for Biorenewable Chemicals Follow this and additional works at: http://lib.dr.iastate.edu/cbirc_annualreports Part of the Biomedical Engineering and Bioengineering Commons, and the Chemical Engineering Commons Recommended Citation NSF Engineering Research Center for Biorenewable Chemicals, "NSF Engineering Research Center for Biorenewable Chemicals, Third Year Renewal Proposal, Volume II" (2011). Center for Biorenewable Chemicals Annual Reports. 5. http://lib.dr.iastate.edu/cbirc_annualreports/5 This Book is brought to you for free and open access by the NSF Engineering Research Center for Biorenewable Chemicals at Iowa State University Digital Repository. It has been accepted for inclusion in Center for Biorenewable Chemicals Annual Reports by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. NSF Engineering Research Center for Biorenewable Chemicals Transforming the THIRD YEAR RENEWALchemical PROPOSALindustry for a sustainable future VOLUME II April 7, 2011 Dr. Brent Shanks, Director Dr. Basil Nikolau, Deputy Director Core Partner Institutions Iowa State University (Lead) Rice University University of California, Irvine University of New Mexico University of Virginia University of Wisconsin Transforming the chemical
    [Show full text]
  • Biosynthesis of Lignans and Norlignans
    J Wood Sci (2007) 53:273–284 © The Japan Wood Research Society 2007 DOI 10.1007/s10086-007-0892-x REVIEW ARTICLE Shiro Suzuki · Toshiaki Umezawa Biosynthesis of lignans and norlignans Received: January 24, 2007 / Accepted: March 13, 2007 / Published online: June 5, 2007 Abstract Lignans and norlignans constitute abundant class- tic lignans in cancer therapies and sesamin in health and es of phenylpropanoids. Biosynthesis of these compounds nutrition. In addition, lignans and norlignans are often bio- has received widespread interest, mainly because they have synthesized and deposited in signifi cant amounts in the various clinically important biological activities. In addition, heartwood region of trees as a metabolic event of heart- lignans and norlignans are often biosynthesized and depos- wood formation, probably preventing heart rot by heart-rot ited in signifi cant amounts in the heartwood region of trees fungi. Because heartwood formation is specifi c to trees and as a metabolic event of heartwood formation, probably pre- does not occur in herbaceous plants, biosynthesis of lignans venting heart rot by heart-rot fungi. Furthermore, biosyn- and norlignans can be a clue to elucidating heartwood for- thetic reactions of lignans and norlignans involve unique mation mechanisms. stereochemical properties that are of great interest in terms Furthermore, biosynthetic reactions of lignans and nor- of bioorganic chemistry and are expected to provide a lignans involve unique stereochemical properties that are model for biomimetic chemistry and its application. We of great interest in terms of bioorganic chemistry and are outline the recent advances in the study of lignan and nor- expected to provide a model for biomimetic chemistry and lignan biosynthesis.
    [Show full text]
  • Eugenol and Isoeugenol, Characteristic Aromatic Constituents of Spices, Are Biosynthesized Via Reduction of a Coniferyl Alcohol Ester
    Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester Takao Koeduka*†, Eyal Fridman*†‡, David R. Gang†§, Daniel G. Vassa˜ o¶, Brenda L. Jackson§, Christine M. Kishʈ, Irina Orlovaʈ, Snejina M. Spassova**, Norman G. Lewis¶, Joseph P. Noel**, Thomas J. Baiga**, Natalia Dudarevaʈ, and Eran Pichersky*†† *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Street, Ann Arbor, MI 48109-1048; §Department of Plant Sciences and Institute for Biomedical Science and Biotechnology, University of Arizona, Tucson, AZ 85721-0036; ¶Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340; ʈDepartment of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907; and **Howard Hughes Medical Institute, Jack H. Skirball Chemical Biology and Proteomics Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 Communicated by Anthony R. Cashmore, University of Pennsylvania, Philadelphia, PA, May 5, 2006 (received for review March 31, 2006) Phenylpropenes such as chavicol, t-anol, eugenol, and isoeugenol are produced by plants as defense compounds against animals and microorganisms and as floral attractants of pollinators. Moreover, humans have used phenylpropenes since antiquity for food pres- ervation and flavoring and as medicinal agents. Previous research suggested that the phenylpropenes are synthesized in plants from substituted phenylpropenols, although the identity of the en- zymes and the nature of the reaction mechanism involved in this transformation have remained obscure. We show here that glan- dular trichomes of sweet basil (Ocimum basilicum), which synthe- size and accumulate phenylpropenes, possess an enzyme that can use coniferyl acetate and NADPH to form eugenol.
    [Show full text]
  • European Patent Office U.S. Patent and Trademark Office
    EUROPEAN PATENT OFFICE U.S. PATENT AND TRADEMARK OFFICE CPC NOTICE OF CHANGES 89 DATE: JULY 1, 2015 PROJECT RP0098 The following classification changes will be effected by this Notice of Changes: Action Subclass Group(s) Symbols deleted: C12Y 101/01063 C12Y 101/01128 C12Y 101/01161 C12Y 102/0104 C12Y 102/03011 C12Y 103/01004 C12Y 103/0103 C12Y 103/01052 C12Y 103/99007 C12Y 103/9901 C12Y 103/99013 C12Y 103/99021 C12Y 105/99001 C12Y 105/99002 C12Y 113/11013 C12Y 113/12012 C12Y 114/15002 C12Y 114/99028 C12Y 204/01119 C12Y 402/01052 C12Y 402/01058 C12Y 402/0106 C12Y 402/01061 C12Y 601/01025 C12Y 603/02027 Symbols newly created: C12Y 101/01318 C12Y 101/01319 C12Y 101/0132 C12Y 101/01321 C12Y 101/01322 C12Y 101/01323 C12Y 101/01324 C12Y 101/01325 C12Y 101/01326 C12Y 101/01327 C12Y 101/01328 C12Y 101/01329 C12Y 101/0133 C12Y 101/01331 C12Y 101/01332 C12Y 101/01333 CPC Form – v.4 CPC NOTICE OF CHANGES 89 DATE: JULY 1, 2015 PROJECT RP0098 Action Subclass Group(s) C12Y 101/01334 C12Y 101/01335 C12Y 101/01336 C12Y 101/01337 C12Y 101/01338 C12Y 101/01339 C12Y 101/0134 C12Y 101/01341 C12Y 101/01342 C12Y 101/03043 C12Y 101/03044 C12Y 101/98003 C12Y 101/99038 C12Y 102/01083 C12Y 102/01084 C12Y 102/01085 C12Y 102/01086 C12Y 103/01092 C12Y 103/01093 C12Y 103/01094 C12Y 103/01095 C12Y 103/01096 C12Y 103/01097 C12Y 103/0701 C12Y 103/08003 C12Y 103/08004 C12Y 103/08005 C12Y 103/08006 C12Y 103/08007 C12Y 103/08008 C12Y 103/08009 C12Y 103/99032 C12Y 104/01023 C12Y 104/01024 C12Y 104/03024 C12Y 105/01043 C12Y 105/01044 C12Y 105/01045 C12Y 105/03019 C12Y 105/0302
    [Show full text]
  • Integrative Systems Biology Applied to Toxicology
    Integrative Systems Biology Applied to Toxicology Kristine Grønning Kongsbak PhD Thesis January 2015 Integrative Systems Biology Applied to Toxicology Kristine Grønning Kongsbak Søborg 2015 FOOD-PHD-2015 PhD Thesis 2015 Supervisors Professor Anne Marie Vinggaard Senior Scientist Niels Hadrup Division of Toxicology and Risk Assessment National Food Institute Technical University of Denmark Associate Professor Aron Charles Eklund Center for Biological Sequence Analysis Department for Systems Biology Technical University of Denmark Associate Professor Karine Audouze Mol´ecules Th´erapeutiques In Silico Paris Diderot University Funding This project was supported financially by the Ministry of Food, Agriculture and Fisheries of Denmark and the Technical University of Denmark. ©Kristine Grønning Kongsbak FOOD-PHD: ISBN 978-87-93109-30-8 Division of Toxicology and Risk Assessment National Food Institute Technical University of Denmark DK-2860 Søborg, Denmark www.food.dtu.dk 4 Summary Humans are exposed to various chemical agents through food, cosmetics, pharma- ceuticals and other sources. Exposure to chemicals is suspected of playing a main role in the development of some adverse health effects in humans. Additionally, European regulatory authorities have recognized the risk associated with combined exposure to multiple chemicals. Testing all possible combinations of the tens of thousands environmental chemicals is impractical. This PhD project was launched to apply existing computational systems biology methods to toxicological research. In this thesis, I present in three projects three different approaches to using com- putational toxicology to aid classical toxicological investigations. In project I, we predicted human health effects of five pesticides using publicly available data. We obtained a grouping of the chemical according to their potential human health ef- fects that were in concordance with their effects in experimental animals.
    [Show full text]
  • Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’S Disease
    Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2018, Article ID 5194016, 20 pages https://doi.org/10.1155/2018/5194016 Research Article Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease Zhenyan Song , Fang Yin, Biao Xiang, Bin Lan, and Shaowu Cheng Te Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China Correspondence should be addressed to Shaowu Cheng; [email protected] Received 30 March 2018; Accepted 30 May 2018; Published 27 June 2018 Academic Editor: Ling Yang Copyright © 2018 Zhenyan Song et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In traditional Chinese medicine (TCM), Acori Tatarinowii Rhizoma (ATR) is widely used to treat memory and cognition dysfunction. Tis study aimed to confrm evidence regarding the potential therapeutic efect of ATR on Alzheimer’s disease (AD) using a system network level based in silico approach. Study results showed that the compounds in ATR are highly connected to AD-related signaling pathways, biological processes, and organs. Tese fndings were confrmed by compound-target network, target-organ location network, gene ontology analysis, and KEGG pathway enrichment analysis. Most compounds in ATR have been reported to have antifbrillar amyloid plaques, anti-tau phosphorylation, and anti-infammatory efects. Our results indicated that compounds in ATR interact with multiple targets in a synergetic way.
    [Show full text]
  • British Journal of Dermatology
    British Journal of Dermatology December 2007 - Vol. 157 Issue 6 Page I-1335 Contents pages I–XI Snippets Research Snippets pages xxi–xxi Topical review Paraneoplastic hypertrichosis lanuginosa acquisita: uncommon or overlooked? P.H.T.J. Slee, R.I.F. van der Waal, J.H. Schagen van Leeuwen, R.A. Tupker, R. Timmer, C.A. Seldenrijk and M.A.M. van Steensel pages 1087–1092 Review articles The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humans P.S. Friedmann pages 1093–1102 Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research E. Guttman-Yassky and J.G. Krueger pages 1103–1115 Guidelines Guidelines for evaluation and management of urticaria in adults and children C.E.H. Grattan and F. Humphreys on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee pages 1116–1123 Original articles Cutaneous biology Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human α- defensins from neutrophils Y. Zheng, F. Niyonsaba, H. Ushio, I. Nagaoka, S. Ikeda, K. Okumura and H. Ogawa pages 1124–1131 Microarray analysis of aberrant gene expression in actinic keratosis: effect of the Toll-like receptor-7 agonist imiquimod A. Torres, L. Storey, M. Anders, R.L. Miller, B.J. Bulbulian, J. Jin, S. Raghavan, J. Lee, H.B. Slade and W. Birmachu pages 1132–1147 Biphasic expression of stromal cell-derived factor-1 during human wound healing A. Toksoy, V. Müller, R. Gillitzer and M. Goebeler pages 1148–1154 Original articles Clinical and laboratory investigations CTACK /CCL27 expression in psoriatic skin and its modification after administration of etanercept A.
    [Show full text]
  • Genome Sequencing of Herb Tulsi (Ocimum Tenuiflorum) Unravels Key Genes Behind Its Strong Medicinal Properties Atul K
    Upadhyay et al. BMC Plant Biology (2015) 15:212 DOI 10.1186/s12870-015-0562-x RESEARCH ARTICLE Open Access Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties Atul K. Upadhyay1, Anita R. Chacko1, A. Gandhimathi1, Pritha Ghosh1, K. Harini1, Agnel P. Joseph1, Adwait G. Joshi1,3, Snehal D. Karpe1, Swati Kaushik1, Nagesh Kuravadi2, Chandana S Lingu2, J. Mahita1, Ramya Malarini2, Sony Malhotra1, Manoharan Malini1, Oommen K. Mathew1,4, Eshita Mutt1, Mahantesha Naika1, Sathyanarayanan Nitish1, Shaik Naseer Pasha1,3, Upadhyayula S. Raghavender1, Anantharamanan Rajamani2, S Shilpa2, Prashant N. Shingate1,3, Heikham Russiachand Singh2, Anshul Sukhwal1,4, Margaret S. Sunitha1, Manojkumar Sumathi2, S. Ramaswamy2, Malali Gowda2* and Ramanathan Sowdhamini1* Abstract Background: Krishna Tulsi, a member of Lamiaceae family, is a herb well known for its spiritual, religious and medicinal importance in India. The common name of this plant is ‘Tulsi’ (or ‘Tulasi’ or ‘Thulasi’) and is considered sacred by Hindus. We present the draft genome of Ocimum tenuiflurum L (subtype Krishna Tulsi) in this report. The paired-end and mate-pair sequence libraries were generated for the whole genome sequenced with the Illumina Hiseq 1000, resulting in an assembled genome of 374 Mb, with a genome coverage of 61 % (612 Mb estimated genome size). We have also studied transcriptomes (RNA-Seq) of two subtypes of O. tenuiflorum, Krishna and Rama Tulsi and report the relative expression of genes in both the varieties. Results: The pathways leading to the production of medicinally-important specialized metabolites have been studied in detail, in relation to similar pathways in Arabidopsis thaliana and other plants.
    [Show full text]