Translational Science: From Basic to Clinical Immunology and Allergy 28TH SYMPOSIUM Collegium Internationale Allergologicum Translational Science: From Basic to Ischia Clinical Immunology and Allergy ISCHIA, 25-30 APRIL 2010 Final Program 28th Symposium of the Collegium Internationale Allergologicum 25-30 APRIL 2010 Ischia, Italy www.ciaweb.org Table of Contents: Welcome Letter . .1 Alain L. de Weck Travel Grant Recipients . .2 General Information . 3–4 Social Events . .5 Optional Excursions . 6 Lacco Ameno Map . .7 Program-at-a-Glance . 8–9 Schedule of Events . .10–24 Abstracts . .25–104 Speaker and Chair Index . .105–107 Supporters . Back Cover TRANSLatiONAL SCIENCE: FROM Basic TO CLINicaL IMMUNOLOGY AND ALLERGY President Dear Colleagues, Gianni Marone It is with great pleasure that we welcome you to the 28th Symposium of the Vice President/ Collegium Internationale Allergologicum on Translational Science: From Basic to Past Secretary General Clinical Immunology and Allergy from 25-30 April 2010 in Ischia, Italy. Stephen Galli The purpose of the meeting is to bring translational scientists, clinical immunologists and allergists together to foster interdisciplinary approaches to Secretary General understand and treat immune-based disorders. Stephen Holgate As in previous years, the majority of the scientific program will be given over to Past President free communications that will be presented either as oral abstract presentations Johannes Ring or as poster discussions. The Collegium’s unique organizational structure and membership guidelines ensure that the science presented at the biennial Council Members symposia of the Collegium is not only important, but contains many late-breaking Mübeccel Akdis developments. Bruce Bochner Sven-Erik Dahlén We believe that the venue we have chosen to accommodate scientists and Fatima Ferreira accompanying persons follows the traditions and style that characterize the Jean Marshall meetings of the Collegium. Ischia is a truly inspirational island to visit from a Hirohisa Saito historical perspective as well as in regards to social events. Its rich culture Richard Stevens reflects its exciting past. Known as the “Green Island” for its abundance of woods Ronald van Ree and gardens, it was the first site in Italy to be colonized by the Greeks, “Magna Grecia.” The Greeks were attracted to the island by the many hot springs, whose Symposium Organizers healing properties still attract visitors worldwide. The Archeological Museum and Gianni Marone Excavations of Pithecusae are also just across the road from the venue. Massimo Triggiani On behalf of the Collegium Council Members, thank you for attending the 28th Symposium in Ischia! From the beginning, the Collegium was intended to be an exclusive group of friends pursuing excellence in research in a spirit of open intellectual exchange at meetings held in interesting and stimulating locations. We will again strive to fulfill this vision over the next week in Ischia. Yours sincerely, Executive Secretariat 555 East Wells Street Gianni Marone, MD FRCP Massimo Triggiani, MD PhD Suite 1100 President and Symposium Organizer Symposium Organizer Milwaukee, WI 53202 United States Tel: +1 414 918 3018 Fax: + 1 414 276 3349 [email protected] www.ciaweb.org 28th Symposium of the Collegium Internationale Allergologicum • 25-30 APRIL 2010 • Ischia 1 Alain L. de Weck Travel Grant Recipients For the first time, Alain L. de Weck Travel Grants have been awarded to young scientists that are presenting an abstract during the meeting. Each applicant was asked to provide a short letter of application, a copy of their abstract, a letter of recommendation from a current member of the Collegium and a copy of their Curriculum Vitae. Waived registration and a travel grant were awarded to the following attendees: Moran Elishmereni, Israel Angela Simpson, United Kingdom Stefan Feichtner, Austria Krisztina Szalai, Hungary Mitchell Grayson, United States Meri Tulic, Australia Simon Hogan, United States Luca Vangelista, Italy Rosetta Pedotti, Italy Michael Wallner, Austria Catherine Ptaschinski, Australia Hilary Whitworth, United Kingdom Travel Grant Recipients will be awarded with a certificate presented by Professor Alain L. de Weck during the Gala Dinner on 29 April 2010. The Collegium would like to thank the members who contributed to the Alain L. de Weck Travel Grant Fund (included in the membership renewal form) and the following companies: CSL Behring, Italy Indoor Biotechnologies 2 TRANSLatiONAL SCIENCE: FROM Basic TO CLINicaL IMMUNOLOGY AND ALLERGY General Information The 28th Symposium of the Collegium is held on the Hospitality Desk beautiful island of Ischia, located in the Bay of Naples, The Hospitality Desk is located in the lobby of the Regina 10 km off the western coast of Italy. Isabella Hotel. Delegates and accompanying persons will be able to sign up for excursions and ask for advice Ischia, historically called Pithecusae, has been colonized regarding activities in Ischia. by the Greeks, Romans, Saracens, Turks, and Aragonese; all of whom were interested in its excellent strategic Hours: position as well as its therapeutic hot-spring waters Monday, 26 April 8:00 – 12:00 and of course its attractive landscape. The result of all Wednesday, 28 April 7:00 – 11:00 this varied history can be seen in the ruins of various Thursday, 29 April 7:00 – 11:00 outposts, towers, and “tufa” rock shelters hidden all over the island. Language The official language of the 28th Symposium is English, Ischia, the “Green Island,” is extraordinary because and the official language of Ischia is Italian. English and it offers nature, culture, history and myth within a German are also widely spoken on the island. framework of breathtaking landscape and picturesque architecture. Lunches Airport Transfers Buffet-style lunches will be served in the Regina Isabella Restaurant during the following times: Transfers to and from the Naples Airport or the Naples Central Train Station are included in the registration Monday, 26 April 13:30 – 14:45 fee. Please confirm your departure pick-up time at the Wednesday, 28 April 13:15 – 14:30 Registration Desk located in the Angelo Rizzoli Conference Thursday, 29 April 13:00 – 14:15 Centre (ARCC). Lunch is included in the registration fee for delegates, accompanying persons and children. CME The 28th Symposium of the Collegium Internationale Oral Abstract Sessions Allergologicum will offer Continuing Medical Education Oral Abstract Sessions will take place on 26, 27, 28, 29 (CME) credits through the European Accreditation and 30 April. All Oral Abstract Sessions will take place Council for Continuing Medical Education (EACCME). in the Angelo Rizzoli Conference Centre (ARCC), which EACCME credits are recognized by the American Medical is directly across the Santa Restituta Square from the Association (AMA) toward the Physician’s Recognition headquarter hotel, the Regina Isabella. Award (PRA). To convert EACCME to AMA PRA category 1 credit, contact the AMA. All Oral Abstract Session presenters will be given 12 minutes to speak and 5 minutes for question and In order to receive your CME certificate by email, please answer. It is the responsibility of the chairpersons to fill out the CME Self-Reporter Form located in your keep the session on time. registration packet and return it to the Registration Desk in the Angelo Rizzoli Conference Centre (ARCC). Poster Sessions Poster Sessions will take place on 26, 28 and 29 April in Coffee Breaks the Gallery of Posters, which acts as the walk-way to the Coffee breaks are included in the registration fee for Angelo Rizzoli Conference Centre (ARCC). An assortment delegates and will be served daily. Coffee will be served of wine, cheese and other refreshments will be served. outside the Angelo Rizzoli Conference Centre (ARCC) and Poster presenters will stand next to their posters in the Gallery of Posters; please check the Schedule of during the session and be available for questions and Events for exact times. discussion. Authors should set posters on Monday, 26 April 2010 before 17:00. Currency The currency used in Ischia is the Euro. There are ATMs, Proceedings or Bancomats, widely available for cash withdrawal. Papers from the 28th Symposium will be published by Credit cards are also accepted at most hotels, Pacini Editore. restaurants and shops. Online submission is now open at Electricity http://mc.manuscriptcentral.com/cia2010. The electrical current in Italy is AC - the cycle is 50Hz Deadline for Submission: 30 June 2010 220V. The European plug with round prongs is used. Length of Manuscript Evaluations Oral presentations: 3 printed pages. This is equivalent Evaluation forms are included in the registration packet. to approximately 6.0 double spaced manuscript pages, Please fill out your form and return it to the Registration including tables, illustrations and references. Desk in the Angelo Rizzoli Conference Centre (ARCC). Poster presentations: 2 printed pages. This is equivalent to approximately 4.0 double-spaced manuscript pages, including tables, illustrations and references. Please note that per figure and table, 0.5 printed page has to be calculated. 28th Symposium of the Collegium Internationale Allergologicum • 25-30 APRIL 2010 • Ischia 3 General Information Registration The registration fee for accompanying persons and The Registration Desk is located in the Angelo Rizzoli children includes: Conference Centre (ARCC) on all days except Sunday, Airport Transfer on Arrival 25 April, when it is