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Joshua Y. Yang 1 (619) 944-9009 · [email protected] JOSHUA Y. YANG www.linkedin.com/in/joshuayoungyang www.joshuayang.com BACKGROUND With a background in life sciences technologies development, unmet clinical needs discovery, and biotechnology and healthcare entrepreneurship, Josh invents and commercializes biomedical technologies that he can translate into clinical practice. He also works to identify promising biotech and healthcare innovations and startups for investment opportunities and was named to the Forbes 30 Under 30 Healthcare list in 2021. Currently, he is pursuing a triple MD/PhD/MBA at the Johns Hopkins University School of Medicine Department of Biomedical Engineering and the Stanford University Graduate School of Business, where he was selected as a Siebel Scholar. His startup Nephrosant has raised over $22M in funding to commercialize a low-cost, non-invasive diagnostic assay for kidney injury. EDUCATION Stanford University Graduate School of Business | Stanford, CA 09/201 9 – Present Master of Business Administration, M.B.A. (Expected 2021) Siebel Scholar Johns Hopkins University School of Medicine | Baltimore, MD 08/2016 – 12/2018 Doctor of Medicine, M.D. (On LOA) Doctor of Philosophy in Bioengineering, Ph.D. Sigma Xi Attended fully funded with stipend on the Medical Scientist Training Program Grant University of California, San Francisco | San Francisco, CA 08/2015 – 06/2016 University of California, Berkeley | Berkeley, CA Master of Engineering in Translational Medicine, M.Eng. University of California, San Diego | La Jolla, CA 09/2011 – 06/2015 Bioengineering: Biotechnology, B.S. and General Biology, B.S. Valedictorian in Bioengineering, Summa Cum Laude, Phi Beta Kappa, Tau Beta Pi Attended fully funded with stipend on the Jacobs School and Regents Scholarship VENTURE CAPITAL EXPERIENCE SeaX Ventures 08/2020 – Present Venture capital firm investing globally in deep-tech companies Role: Venture Fellow • Sourced and conducted due diligence on venture capital investment opportunities from the Y Combinator summer cohort for investment opportunities relevant to RISE’s investment thesis leading to a biotech investment. • Developed a business expansion strategy and action plan for RISE’s expansion into Indonesia, which was presented to the RISE CEO and leadership team. • Mentored by Kid Parchariyanon, Managing Partner of SeaX Ventures. InSITE Fellows 12/2019 – Present Role: InSITE Fellow • Developed a microbiome investment thesis based on industry research via interviews with startup companies, pharmaceutical companies, CROs, investors, governmental/regulatory agencies, academic thought leaders, and analytical service providers. • Completed practical training on venture capital term sheets taught by WSGR attorneys. Pear Ventures 11/2019 – Present Role: Pear Fellow 1 • Sourced leading startups and entrepreneurial founders, conduct due diligence, execute investment processes, and support portfolio companies focused on life sciences and healthcare. • Mentored by Pejman Nozad and Mar Hershenson, Founding Managing Partners of Pear Ventures. UCSF Clinical & Translational Science Institute (CTSI) Catalyst Program 03/2016 – 06/2016 Translational accelerator providing over $22 million in seed funds for biotechnology startups Role: Catalyst Program Intern • Created a market report detailing changing trends and opportunities in the mechanical ventilation field for the Esophageal Manometry for Airway Protection (EMAP) team, contributing to successful funding by the CTSI Catalyst program in Spring 2016. • Reviewed proposals for medical devices track submissions, evaluating commercialization potential and development feasibility. ENTREPRENEURIAL EXPERIENCE Nephrosant, Inc. www.nephrosant.com 12/2015 – Present Series A biotechnology startup commercializing noninvasive diagnostics for kidney injury Role: Co-Founder • Invented noninvasive technologies to determine risk of kidney injury more sensitively than existing clinical solutions, for which multiple intellectual property filings have been and are being pursued. • Managed collaborative partnerships with industry partners for product development, leading to successful prototype completion within established budget. • Directed operations of research associates, interns, and students in the clinical development of our flagship product, the QiSant Assay and Score. • Fundraised at numerous startup competitions, entrepreneurial venues, and VC investors leading to Series A and prior investments totaling $22 million. Helispot, Inc. 06/2017 – 12/2018 Role: Co-Founder • Developed an isothermal assay for the detection of nucleic acids based on bioengineered helicase technology. • Consulted industry experts in life sciences and diagnostics fields and analyzed market trends in DNA amplification field to pivot company’s direction. • Oversaw five MD and PhD students in development of marketing and commercialization strategy. • Wrote a proposal and received an industry grant from Integrated DNA Technologies for further development of the assay technology. PATENTS / INTELLECTUAL PROPERTY 1. US20200032331A1 16/597,782 - A Novel Immunoprobe-Based Method to Assess Organ Injury Status Through a Biofluid-Based Cell-Free DNA (cfDNA) Assay • Sarwal MM, Sigdel TK, Yang JY. 2. USPTO Provisional App. No. 62/793,870 - Urine metabolomics based method of detecting renal allograft injury • Sarwal MM, Sigdel TK, Schroeder A, Yang JY. 3. USPTO Provisional App. No. 62/896,296 - A novel noninvasive method to quantify kidney function and functional decline through urinary biomarker quantitation • Sarwal MM, Yang JY. 4. USPTO Provisional App. No. 63/046,539 - Markers for Monitoring Organ Transplant Rejection • Colucci M, Yang JY 5. USPTO Provisional App. – Kits for Stabilization of Urine Samples • Zawada R, Yang JY. 6. A novel noninvasive method to quantify kidney stone burden and recurrence risk through urinary biomarker quantitation • Sarwal MM, Yang JY, Chi T, Stoller M. UCSF Invention Disclosure No. SF2020-033 7. Urinary biomarkers for IgA nephropathy detection and progression risk • Sarwal MM, Yang JY. UCSF Invention Disclosure No. SF2020-040 2 8. Isothermal Superhelicase-dependent Amplification of Nucleic Acids • Ha T, Yang J. Johns Hopkins University Invention Disclosure No. C14980 CONSULTING EXPERIENCE Independent Consulting 02/2020 – Present Role: Ad hoc Consulting Services • Consult for biotechnology, therapeutics, diagnostics companies, and venture capital firms providing expertise in therapeutics, diagnostics, and synthetic biology. McKinsey & Co. 01/2018 – 05/2019 Role: Ad hoc Consulting Services, Reference: Lydia The ([email protected]) • Assessed and provided recommendations on various combinations of drug targets and immunology indications. • Analyzed market dynamics and scientific environment for various oncology and immunology indications. GRANTS 1. Integrated DNA Technologies (IDT) Synthetic Biology Grant Program 01/2018 • Role: Principal Investigator @ Helispot, Inc. • Project: Development of enhanced superhelicases through synthetic biology approaches 2. Atomwise Artificial Intelligence Molecular Screen (AIMS) Award 02/2019 • Role: Co-Principal Investigator @ UCSF • Project: Development of small molecular inhibitors of IgE-FcεRI receptor interactions 3. FDA Grant P50FD006424, Subaward 11351sc (UCSF-Stanford Pediatric Device Accelerator) 09/01/2018 – 08/31/2019 • Role: Principal Investigator @ Nephrosant, Inc. • Project: Development of a noninvasive urinary dipstick for pediatric kidney transplant rejection 4. Rheumatology Research Foundation (RRF) 05/2019 • Role: Recipient, Researcher @ UCSD • Project: NSAID-Induced Nephropathy in Patients with Rheumatic Diseases and Potential Interventions 5. uBiome Microbiome Grant Initiative 05/2019 • Role: Principal Investigator @ UCSF • Project: Urinary microbiome changes in kidney transplant rejection and immunosuppression 6. The Roddenbury Foundation Catalyst Fund Grant 11/2020 • Role: Principal Investigator @ Cerviscope • Project: Cerviscope: A point-of-care screening tool for cervical cancer LEADERSHIP TRAINING Stanford Graduate School of Business GSBelonging Inclusion Ambassador 09/2020 - Present Role: Inclusion Ambassador • Trained on diversity, equity, and inclusion principles related to developing facilitation skills and building inclusive environments during mentorship. • Led small group discussions on DE&I through creation of a space where people can have genuine conversations about who we are and how our backgrounds shape our experiences at the GSB and beyond. Robertson Center for Intercultural Leadership 01/2016 – 05/2016 Role: Intern • Developed advanced intercultural competencies through planning and hosting events at the International House of UC Berkeley. • Led and hosted the first-ever LGBTQ Pride event at the International House, which was attended by a record number of residents. Co-led a PechaKucha event, where I shared my story about defining and finding community in an LGBTQ community in Spain. Global Leadership Course (formerly Intercultural Leadership Initiative) 09/2015 – 12/2015 Role: Certificate Participant 3 • Underwent 50+ hours of training to develop competencies in intercultural and global leadership skills and mindsets with a capstone project of producing a video detailing the harm of stereotypes and microaggressions. • Canvassed in underserved minority neighborhoods within specific districts in the Bay Area, such as Fruitvale, a Hispanic community in Oakland, CA and the Tenderloin, San Francisco’s original LGBT community.
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