Anti-CDC16 Monoclonal Antibody, Clone FQS22278 (DCABH-5252) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-CDC16 monoclonal antibody, clone FQS22278 (DCABH-5252) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit monoclonal to Apc6

Antigen Description Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Immunogen Synthetic peptide, corresponding to residues in Human Apc6 (UniProt: Q13042).

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Rat, Human

Clone FQS22278

Purity Tissue culture supernatant

Conjugate Unconjugated

Applications WB, ICC/IF

Positive Control HepG2, HT1080, HUVEC and HeLa cell lysates; HeLa cells.

Format Liquid

Size 100 μl

Buffer Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA

Preservative 0.01% Sodium Azide

Storage Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol CDC16

Synonyms CDC16; cell division cycle 16 homolog (S. cerevisiae); CDC16 (cell division cycle 16, S. cerevisiae, homolog) , CDC16 cell division cycle 16 homolog (S. cerevisiae); cell division cycle protein 16 homolog; ANAPC6; anaphase promoting complex; subunit 6; A

Entrez Gene ID 8881

Protein Refseq NP_001072113

UniProt ID A0A024RDZ2

Chromosome Location 13q34

Pathway APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C- mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem;

Function binding; protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]