DOCSLIB.ORG

Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (2Nd Edition)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (2Nd Edition) AUTOPHAGY 2016, VOL. 0, NO. 0, 1–215 http://dx.doi.org/10.1080/15548627.2015.1100356 EDITORIAL Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition) Daniel J Klionsky1766,1771*, Kotb Abdelmohsen851, Akihisa Abe1253, Md Joynal Abedin1784, Hagai Abeliovich428, 5 Abraham Acevedo Arozena800, Hiroaki Adachi1822, Christopher M Adams1690, Peter D Adams58, Khosrow Adeli2010, Peter J Adhihetty1645, Sharon G Adler710, Galila Agam68, Rajesh Agarwal1607, Manish K Aghi1556, Maria Agnello1848, Patrizia Agostinis673, Patricia V Aguilar1987, Julio Aguirre-Ghiso795,797, Edoardo M Airoldi90,425, Slimane Ait-Si-Ali1394, Takahiko Akematsu2039, Emmanuel T Akporiaye1112, Mohamed Al-Rubeai1412, Guillermo M Albaiceta1311, Chris Albanese366, Diego Albani569, Matthew L Albert524, Jesus Aldudo129, Hana Algul€ 1179, Mehrdad Alirezaei1213, 10 Iraide Alloza650,899, Alexandru Almasan207, Maylin Almonte-Becerril531, Emad S Alnemri1228, Covadonga Alonso552, Nihal Altan-Bonnet859, Dario C Altieri1220, Silvia Alvarez1516, Lydia Alvarez-Erviti1413, Sandro Alves108, Giuseppina Amadoro871, Atsuo Amano942, Consuelo Amantini1573, Santiago Ambrosio1477, Ivano Amelio767, Amal O Amer929, Mohamed Amessou2122, Angelika Amon737, Zhenyi An1557, Frank A Anania294, Stig U Andersen6, Usha P Andley2111, Catherine K Andreadi1711, Nathalie Andrieu-Abadie509, Alberto Anel2058, David K Ann59, 15 Shailendra Anoopkumar-Dukie391, Manuela Antonioli843,1911, Hiroshi Aoki1813, Nadezda Apostolova1432, Saveria Aquila1519, Katia Aquilano1900, Koichi Araki295, Eli Arama2131, Agustin Aranda460, Jun Araya599, Alexandre Arcaro1491, Esperanza Arias27, Hirokazu Arimoto1241, Aileen R Ariosa1770, Jane L Armstrong1956, Thierry Arnould1795, Ivica Arsov2153, Katsuhiko Asanuma684, Valerie Askanas1949, Eric Asselin1891, Ryuichiro Atarashi805, Sally S Atherton372, Julie D Atkin724, Laura D Attardi1146, Patrick Auberger1809, Georg Auburger382, Laure Aurelian1748, 20 Riccardo Autelli2021, Laura Avagliano1043,1777, Maria Laura Avantaggiati367, Limor Avrahami1181, Suresh Awale2015, Tiziana Bachetti, Jonathan M Backer29, Dong-Hun Bae1959, Jae-sung Bae686, Ok-Nam Bae412, Soo Han Bae2150, Eric H Baehrecke1750, Seung-Hoon Baek18, Stephen Baghdiguian1386, Agnieszka Bagniewska-Zadworna2, Hua Bai91, Jie Bai676, Xue-Yuan Bai1148, Yannick Bailly895, Kithiganahalli Narayanaswamy Balaji478, Walter Balduini2031, Andrea Ballabio319, Rena Balzan1732, Rajkumar Banerjee241,Gabor Banhegyi1067, Haijun Bao2142, Benoit Barbeau1381, 25 Maria D Barrachina2036, Esther Barreiro472, Bonnie Bartel1011, Alberto Bartolome223, Diane C Bassham558, Maria Teresa Bassi1061, Robert C Bast Jr1290, Alakananda Basu1820, Maria Teresa Batista1597, Henri Batoko1353, Maurizio Battino984, Kyle Bauckman2117, Bradley L Baumgarner1933, K Ulrich Bayer1614, Rupert Beale1572, Jean-Francois¸ Beaulieu1378, George R. Beck Jr49,297, Christoph Becker339, J David Beckham1615, Pierre-AndreB edard 760, Patrick J Bednarski304, Thomas J Begley1150, Christian Behl1437, Christian Behrends768, Georg MN Behrens409, 30 Kevin E Behrns1647, Eloy Bejarano8, Amine Belaid496, Francesca Belleudi1056, Giovanni Benard 503, Guy Berchem716, Daniele Bergamaschi997, Matteo Bergami1419, Ben Berkhout1459, Laura Berliocchi725,Amelie Bernard1770, Monique Bernard1372, Francesca Bernassola1904, Anne Bertolotti802, Amanda S Bess275,Sebastien Besteiro1368, Saverio Bettuzzi1851, Savita Bhalla924, Shalmoli Bhattacharyya987, Sujit K Bhutia849, Caroline Biagosch1174, Michele Wolfe Bianchi527,1396,1399, Martine Biard-Piechaczyk211, Viktor Billes301, Claudia Bincoletto1331, Baris Bingol353, 35 Sara W Bird1143, Marc Bitoun1127, Ivana Bjedov1274, Craig Blackstone854, Lionel Blanc1198, Guillermo A Blanco1515, Heidi Kiil Blomhoff1834, Emilio Boada-Romero1314, Stefan Bockler€ 1483, Marianne Boes1441, Kathleen Boesze-Battaglia1858, Lawrence H Boise289,290, Alessandra Bolino2094, Andrea Boman703, Paolo Bonaldo1845, Luis M Botana1325, Matteo Bordi908, Jurgen€ Bosch616, Joelle Botti1393, German Bou1423, Marina Bouche1053, Marion Bouchecareilh1348, Marie-Josee Boucher1925, Michael E Boulton486, Sebastien G Bouret1951, Patricia Boya134, Michael€ Boyer-Guittaut1362, 40 Peter Bozhkov1167, Nathan Brady377, Vania MM Braga474, Claudio Brancolini2026, Gerhard H Braus356, Jose M Bravo-San Pedro1308, Lisa A Brennan325, Emery H Bresnick2051, Patrick Brest496, Dave Bridges1966, Marie-Agnes Bringer125,491,1473, Marisa Brini1844, Glauber C Brito1328, Bertha Brodin639, Paul S Brookes1898, Eric J Brown355, Karen Brown1711, Hal E Broxmeyer485, Alain Bruhat492,1281,1356, Patricia Chakur Brum1917, John H Brumell450, Nicola Brunetti-Pierri318,1186, Robert J Bryson-Richardson792, Shilpa Buch1799, Alastair M Buchan1841, Hikmet Budak1036, 45 Dmitry V Bulavin119,512,1811, Scott J Bultman1814, Geert Bultynck674, Vladimir Bumbasirevic1489, Yan Burelle1374, Robert E Burke217,218, Margit Burmeister1772, Peter Butikofer€ 1492, Laura Caberlotto2016, Ken Cadwell907, Monika Cahova113, Dongsheng Cai25, Jingjing Cai2132, Qian Cai1032, Sara Calatayud2036, Nadine Camougrand1360, Michelangelo Campanella1721, Grant R Campbell1544, Matthew Campbell1265, Silvia Campello564, Robin Candau1791, Isabella Caniggia2012, Lavinia Cantoni568, Lizhi Cao117, Allan B Caplan1677, Michele Caraglia1066, Claudio Cardinali1058, 50 Sandra Morais Cardoso1598, Jennifer S Carew209, Laura A Carleton885, Cathleen R Carlin102, Silvia Carloni2031, CONTACT Daniel J Klionsky [email protected] Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216. © 2016 Taylor & Francis Group, LLC 2 D. J. KLIONSKY ET. AL. Sven R Carlsson1284, Didac Carmona-Gutierrez1664, Leticia AM Carneiro315, Oliana Carnevali985, Serena Carra1335, Alice Carrier237, Bernadette Carroll911, Caty Casas1341, Josefina Casas1131, Giuliana Cassinelli327, Perrine Castets1481, Susana Castro-Obregon215, Gabriella Cavallini1864, Isabella Ceccherini576, Francesco Cecconi256,563,1908, Arthur I Cederbaum463, ValentınCena~ 200,1298, Simone Cenci2095,1340, Claudia Cerella448, Davide Cervia2025, 55 Silvia Cetrullo1497, Hassan Chaachouay2059, Han-Jung Chae188, Andrei S Chagin642, Chee-Yin Chai634,636, Gopal Chakrabarti1521, Georgios Chamilos1621, Edmond YW Chan1157, Matthew TV Chan182, Dhyan Chandra1017, Pallavi Chandra556, Chih-Peng Chang829, Raymond Chuen-Chung Chang1674, Ta Yuan Chang348, John C Chatham1452, Saurabh Chatterjee1934, Santosh Chauhan535, Yongsheng Che63, Michael E Cheetham1279, Rajkumar Cheluvappa1805, Chun-Jung Chen1168, Gang Chen606,1697, Guang-Chao Chen10, Guoqiang Chen1093, Hongzhuan Chen1092, 60 Jeff W Chen1533, Jian-Kang Chen373, Min Chen251, Mingzhou Chen2137, Peiwen Chen1845, Qi Chen1695, Quan Chen173, Shang-Der Chen139, Si Chen328, Steve S-L Chen11, Wei Chen2158, Wei-Jung Chen840, Wen Qiang Chen993, Wenli Chen1128, Xiangmei Chen1148, Yau-Hung Chen1172, Ye-Guang Chen1266, Yin Chen1465, Yingyu Chen967,969, Yongshun Chen2168, Yu-Jen Chen723, Yue-Qin Chen1160, Yujie Chen1224, Zhen Chen342, Zhong Chen2156, Alan Cheng1723, Christopher HK Cheng185, Hua Cheng1749, Heesun Cheong825, Sara Cherry1859, Jason Chesney1724, 65 Chun Hei Antonio Cheung828, Eric Chevet1377, Hsiang Cheng Chi141, Sung-Gil Chi665, Fulvio Chiacchiera311, Hui-Ling Chiang972, Roberto Chiarelli1848, Mario Chiariello236,575,585, Marcello Chieppa846, Lih-Shen Chin722, Mario Chiong1302, Gigi NC Chiu889, Dong-Hyung Cho685, Ssang-Goo Cho659, William C Cho996, Yong-Yeon Cho106, Young-Seok Cho1079, Augustine MK Choi2128, Eui-Ju Choi665, Eun-Kyoung Choi390,403,694, Jayoung Choi1582, Mary E Choi2126, Seung-Il Choi2149, Tsui-Fen Chou415, Salem Chouaib398, Divaker Choubey1593, Vinay Choubey1963, 70 Kuan-Chih Chow833, Kamal Chowdhury741, Charleen T Chu1879, Tsung-Hsien Chuang838, Taehoon Chun666, Hyewon Chung661, Taijoon Chung992, Yuen-Li Chung1209, Yong-Joon Chwae19, Valentina Cianfanelli257, Roberto Ciarcia1797, Iwona A Ciechomska897, Maria Rosa Ciriolo1900, Mara Cirone1057,Sofie Claerhout1715, Michael J Clague1719, Joan Claria1476, Peter GH Clarke1708, Robert Clarke364, Emilio Clementi1060,1416,Cedric Cleyrat1803, Miriam Cnop1384, Eliana M Coccia582, Tiziana Cocco1478, Patrice Codogno1393,Jorn€ Coers274, Ezra EW Cohen1552, 75 David Colecchia236,575,585, Luisa Coletto8,Nuria S Coll124, Emma Colucci-Guyon523, Sergio Comincini1852, Maria Condello586, Katherine L Cook2105, Graham H Coombs1955, Cynthia D Cooper2108, J Mark Cooper1413, Isabelle Coppens609, Maria Tiziana Corasaniti1405, Marco Corazzari490,1908, Ramon Corbalan1585, Elisabeth Corcelle-Termeau253, Mario D Cordero1923, Cristina Corral-Ramos1306, Olga Corti514,1124, Andrea Cossarizza1789, Paola Costelli2022,Safia Costes1537, Susan L Cotman732, Ana Coto-Montes960, Sandra Cottet574,1709, Eduardo Couve1318, 80 Lori R Covey1029, L Ashley Cowart773, Jeffery S Cox1555, Fraser P Coxon1445, Carolyn B Coyne1869, Mark S Cragg1943, Rolf J Craven1700, Tiziana Crepaldi2024, Jose L Crespo1317, Alfredo Criollo1302, Valeria Crippa566, Maria Teresa Cruz1595, Ana Maria Cuervo27, Jose M Cuezva1294, Taixing Cui1931, Pedro R Cutillas1001, Mark J Czaja28, Maria F Czyzyk-Krzeska1591, Ruben K Dagda, Uta Dahmen1422, Chunsun Dai811, Wenjie Dai1202, Yun Dai2090, Kevin N Dalby1967, Luisa Dalla Valle1844, Guillaume Dalmasso1357, Marcello D’Amelio565, Markus Damme189, Arlette Darfeuille-Michaud1357, 85 Catherine Dargemont964, Victor M Darley-Usmar1451, Srinivasan Dasarathy206, Biplab Dasgupta203, Srikanta Dash1270, Crispin R Dass244, Hazel Marie Davey9, Lester M Davids1579, David Davila228, Roger J Davis1752, Ted M Dawson612, Valina L Dawson614, Paula Daza1922,
Load more

Recommended publications
  • Scheme of Instruction 2018-19
    Scheme of Instruction 2018-19 Contents A. Scheme of Instruction Course Page No. Prefix Preface 3 I Division of Biological Sciences Preface 6 Integrated Ph D Programme in Biological Sciences DB 7 Biochemistry BC 10 Ecological Sciences EC 13 Molecular Biophysics MB 15 Microbiology and Cell Biology MC 20 Molecular Reproduction, Development and Genetics RD 24 Neuroscience NS 26 II Division of Chemical Sciences Preface 28 Integrated Ph D Programme in Chemical Sciences CD 29 Inorganic and Physical Chemistry IP 34 Materials Research MR 38 Organic Chemistry OC 41 Solid State and Structural Chemistry SS 44 III Division of Physical and Mathematical Sciences Preface 47 Instrumentation and Applied Physics IN 48 Mathematics MA 55 Astronomy and Astrophysics AA 69 Physics and Integrated Ph D in Physical Sciences PH 70 High Energy Physics HE 84 IV Division of Electrical Sciences Preface 89 Core requirements for M Tech Degree Programmes M Tech Degree - Computer Science and Engineering M Tech Degree - Telecommunications M Tech Degree – Signal Processing M Tech Degree – Microelectronics Systems M Tech Degree – Electrical Engineering M Tech Degree – Systems Science and Automation M Tech Degree – Electronics Systems Engineering Computer Science and Automation Intelligent Systems and Automation Communication Systems 1 Electronic Devices, Circuits and Technology Power Energy Systems High Voltage and Insulation Systems Electronics and Power Drives Photonic Device Electromagnetics, Microwaves and Antennas Signal Processing, Acoustics and Bioengineering Dissertation
    [Show full text]
  • BRCA1 and BRCA2 Germline Mutation Analysis Among Indian
    BRCA1 and BRCA2 mutations in India 415 BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identifi cation of four novel mutations and high-frequency occurrence of 185delAG mutation KANNAN VAIDYANATHAN1,#, SMITA LAKHOTIA1,#, H M RAVISHANKAR1,#, UMAIRA TABASSUM2, GEETASHREE MUKHERJEE2,* and KUMARAVEL SOMASUNDARAM1,* 1Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India 2Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore 560 068, India #Contributed equally *Corresponding author (Fax, 91-80-23602697; Email, [email protected]) Mutations in the BRCA1 and BRCA2 genes profoundly increase the risk of developing breast and/or ovarian cancer among women. To explore the contribution of BRCA1 and BRCA2 mutations in the development of hereditary breast cancer among Indian women, we carried out mutation analysis of the BRCA1 and BRCA2 genes in 61 breast or ovarian cancer patients from south India with a positive family history of breast and/or ovarian cancer. Mutation analysis was carried out using conformation-sensitive gel electrophoresis (CSGE) followed by sequencing. Mutations were identifi ed in 17 patients (28.0%); 15 (24.6%) had BRCA1 mutations and two (3.28%) had BRCA2 mutations. While no specifi c association between BRCA1 or BRCA2 mutations with cancer type was seen, mutations were more often seen in families with ovarian cancer. While 40% (4/10) and 30.8% (4/12) of families with ovarian or breast and ovarian cancer had mutations, only 23.1% (9/39) of families with breast cancer carried mutations in the BRCA1 and BRCA2 genes. In addition, while BRCA1 mutations were found in all age groups, BRCA2 mutations were found only in the age group of ≤40 years.
    [Show full text]
  • Creating an Effective Platform for Communication and Exchange
    COLLABORATION Creating an effective platform for communication and exchange KNOWLEDGE INTERCHANGE COMMUNICATION NETWORKING ADVANCEMENT The 2013 Annual Report of the Society for Neuro-Oncology Society for NeuroOncology This Annual Report covers the SNO 2013 fiscal year, from July 1st, 2012 through June 30, 2013. INTERCHANGE COLLABORATION COMMUNICATION EXCHANGE PERSPECTIVES A Message from the President INTERCHANGE Dear Colleagues and Friends, As the outgoing President, I am happy to share with you I would like to acknowledge some of the COLLABORATION some of the Society’s accomplishments and endeavors individuals who have contributed to the success of our during my tenure. To begin with, SNO continues to grow Society and by extension furthered the development COMMUNICATION with an overall increase in membership of 11% since of neuro-oncology as a field. First, much appreciation October 2012, with current membership now approaching goes to SNO Foundation members Mark Gilbert 1500 and representation from 42 countries. (chair), Mitchel Berger, Susan Chang and Victor Levin I am likewise happy to share that the impact factor of and members of the Partners Advisory Council for the Society’s official journal,Neuro-Oncology , continues their continued support and guidance as the Society to rise, now standing at 6.1, solidifying its reputation as continues to grow. I would also like to recognize the EXCHANGE the leading journal in the field. Its success is, in large part, members of the Board of Directors for their willingness due to the dedication of the editor-in-chief, W K Alfred to represent the diverse disciplines of the neuro- Yung who completes his successful tenure at the end of oncology community and for their input into critical PERSPECTIVES this year.
    [Show full text]
  • Elucidating the Cancer-Specific Genetic Alteration Spectrum of Glioblastoma Derived Cell Lines from Whole Exome and RNA Sequencing
    www.impactjournals.com/oncotarget/ Oncotarget, Vol. 6, No. 41 Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing Vikas Patil1,*, Jagriti Pal1,* and Kumaravel Somasundaram1 1 Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India * These authors have contributed equally to this work Correspondence to: Kumaravel Somasundaram, email: [email protected] Keywords: glioblastoma, exome & RNA sequencing, cancer-specific mutations, gene fusions, RNA editing Received: May 03, 2015 Accepted: October 05, 2015 Published: October 19, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Cell lines derived from tumor tissues have been used as a valuable system to study gene regulation and cancer development. Comprehensive characterization of the genetic background of cell lines could provide clues on novel genes responsible for carcinogenesis and help in choosing cell lines for particular studies. Here, we have carried out whole exome and RNA sequencing of commonly used glioblastoma (GBM) cell lines (U87, T98G, LN229, U343, U373 and LN18) to unearth single nucleotide variations (SNVs), indels, differential gene expression, gene fusions and RNA editing events. We obtained an average of 41,071 SNVs out of which 1,594 (3.88%) were potentially cancer-specific. The cell lines showed frequent SNVs and indels in some of the genes that are known to be altered in GBM- EGFR, TP53, PTEN, SPTA1 and NF1. Chromatin modifying genes- ATRX, MLL3, MLL4, SETD2 and SRCAP also showed alterations.
    [Show full text]
  • Awards Galore at DBT Foundation Day
    Awards galore at DBT Foundation Day 10 April 2007 | News Image not found or type unknown Awards galore at DBT Foundation Day On March 12, 2007, a series of awards were announced to honor researchers, scientists working in the sciences arena. The Distinguished Biotechnologist Award for the year 2006 has been conferred on Prof. TP Singh for his outstanding contributions in structural biology. Prof. TP Singh headed the Biophysics Department at the All India Institute of Medical Sciences, New Delhi during 1986–August 2006. He obtained his PhD from the Indian Institute of Science, Bangalore in 1975 on structure–function studies of analgesic/anti-inflammatory agents. He has made original and novel contributions to the structural studies of proteins and implemented a strong program on structure-based rational drug design. Significantly, Prof. TP Singh has developed a new program on Clinical Proteomics at AIIMS in collaboration with other faculty members to characterize all the proteins that are expressed during various patho/physiological conditions. His group has already determined more than 50 structures of proteins and their complexes under this program. Dr Manju Sharma, former secretary, DBT, has been honored with the National Award for Senior Woman Bioscientist for the year 2006 in recognition of her vision and incessant efforts in shaping and steering research in biotechnology and new biology and for applying research results for the benefit of the society in the country. The National Award for Young Women Bioscientists for the year 2006 was conferred on Dr Gagandeep Kang, CMC, Vellore and Dr Ramanathan Sowdhamini, NCBS, Bangalore. Dr Gagandeep Kang has been honored for her significant contributions on rotaviral diarrhoeal diseases in children particularly on molecular epidemiology.
    [Show full text]
  • Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3Rd Edition)
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Klionsky, Daniel J., et al. “Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition).” Autophagy, vol. 12, no. 1, Jan. 2016, pp. 1–222. As Published http://dx.doi.org/10.1080/15548627.2015.1100356 Publisher Informa UK Limited Version Author's final manuscript Citable link http://hdl.handle.net/1721.1/116122 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ AUTOPHAGY 2016, VOL. 12, NO. 1, 1–222 http://dx.doi.org/10.1080/15548627.2015.1100356 EDITORIAL Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J Klionsky1745,1749*, Kotb Abdelmohsen840, Akihisa Abe1237, Md Joynal Abedin1762, Hagai Abeliovich425, Abraham Acevedo Arozena789, Hiroaki Adachi1800, Christopher M Adams1669, Peter D Adams57, Khosrow Adeli1981, Peter J Adhihetty1625, Sharon G Adler700, Galila Agam67, Rajesh Agarwal1587, Manish K Aghi1537, Maria Agnello1826, Patrizia Agostinis664, Patricia V Aguilar1960, Julio Aguirre-Ghiso784,786, Edoardo M Airoldi89,422, Slimane Ait-Si-Ali1376, Takahiko Akematsu2010, Emmanuel T Akporiaye1097, Mohamed Al-Rubeai1394, Guillermo M Albaiceta1294, Chris Albanese363, Diego Albani561, Matthew L Albert517, Jesus Aldudo128, Hana Algul€ 1164, Mehrdad Alirezaei1198, Iraide
    [Show full text]
  • Current Excitements in Biochemistry and Molecular Biology for Agriculture and Medicine
    14th FAOBMB Congress and 84th Annual Meeting of SBC (I) Current Excitements in Biochemistry and Molecular Biology for Agriculture and Medicine Centre for Cellular and Molecular Biology, Hyderabad, India 27 – 30 November 2015 Programme Time (h) Day 1; Friday, 27 November 2015 11.00 - 13.00 Registration 12.30 - 13.30 Lunch 13.30 – 14.00 Inauguration 14.00 – 14.05 Announcement of President Elect, FAOBMB Plenary Lecture 1: Kanury V S Rao, India (Takashi Murachi Memorial Lecture) Deciphering the host-pathogen interplay in human macrophages infected with 14.05 - 14.45 Mycobacterium tuberculosis Chairperson: 14.45 - 15.25 Kiyoshi Fukui, Japan Plenary Lecture 2: Shubha Tole, India (Kunio Yagi Lecture) Towards a Blueprint for Building the Brain 15.25 - 15.55 Tea/Coffee Protein Folding and Disease Developmental Biology Epigenetics and miRNA 16.00 - 18.00 Chairperson: Masatsune Kainosho, Japan Chairperson: Polani B. Seshagiri, India Chairperson: K. Satyamoorthy, India L S. Shashidhara, India Manajit Hayer-Hartl, Germany Rakesh K. Mishra, India A comparative genomic analysis of targets of 16.00 - 16.30 The complex chaperone machineries for the Functional Compartmentalization of the Hox protein Ultrabithorax amongst distant folding and assembly of RuBisCO Genome and Epigenetic Regulation of Genes insect species: new insights into evolution of halteres in Drosophila Subramaniam Ganesh, India Tapas Kundu, India Kunihiro Kuwajima, Japan 16.30 - 17.00 Mitochondrial homeostasis and Lysine Acetylation and Arginine Methylation of The problem of protein folding
    [Show full text]
  • A Ten-Microrna Expression Signature Predicts Survival in Glioblastoma
    A Ten-microRNA Expression Signature Predicts Survival in Glioblastoma Sujaya Srinivasan, Irene Rosita Pia Patric, Kumaravel Somasundaram* Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India Abstract Glioblastoma (GBM) is the most common and aggressive primary brain tumor with very poor patient median survival. To identify a microRNA (miRNA) expression signature that can predict GBM patient survival, we analyzed the miRNA expression data of GBM patients (n = 222) derived from The Cancer Genome Atlas (TCGA) dataset. We divided the patients randomly into training and testing sets with equal number in each group. We identified 10 significant miRNAs using Cox regression analysis on the training set and formulated a risk score based on the expression signature of these miRNAs that segregated the patients into high and low risk groups with significantly different survival times (hazard ratio [HR] = 2.4; 95% CI = 1.4–3.8; p,0.0001). Of these 10 miRNAs, 7 were found to be risky miRNAs and 3 were found to be protective. This signature was independently validated in the testing set (HR = 1.7; 95% CI = 1.1–2.8; p = 0.002). GBM patients with high risk scores had overall poor survival compared to the patients with low risk scores. Overall survival among the entire patient set was 35.0% at 2 years, 21.5% at 3 years, 18.5% at 4 years and 11.8% at 5 years in the low risk group, versus 11.0%, 5.5%, 0.0 and 0.0% respectively in the high risk group (HR = 2.0; 95% CI = 1.4–2.8; p,0.0001).
    [Show full text]
  • Book Download
    SOCIETY OF BIOLOGICAL CHEMISTS (INDIA) (1930 – 2011) 1 TABLE OF CONTENTS 1. Goals and activities of SBC(I) 2. Rules and Bye-laws of SBC(I) 3. Past Presidents, Secretaries, Treasurers (with tenure) 4. “Reminiscences on the development of the Society of Biological Chemists (India): a personal perspective” by Prof. N. Appaji Rao 5. “Growth of Biochemistry in India” by Prof. G. Padmanaban 6. Current office bearers 7. Current Executive Committee Members 8. Office staff 9. Past meeting venues of SBC(I) 10. SBC(I) awards, criteria and procedure for applying 11. SBC(I) awardees 12. Current list of life members with address 13. Acknowledgments 2 GOALS AND ACTIVITIES OF SBC(I) To meet a long felt need of scientists working in the discipline of biological chemistry " The Society Of Biological Chemists (India)" was founded in 1930, with its Head Quarters at Indian Institute of Science, Bangalore. It was registered under the Societies Act in the then princely state of Mysore and the memorandum of registration was signed by the late Profs. V. Subramanian, V. N. Patwardhan and C. V. Natarajan, who were leading personalities in the scientific firmament during that period. The Society played a crucial role during the Second World War by advising the Government on the utilization of indigenous biomaterials as food substitutes, drugs and tonics, on the industrial and agricultural waste utilization and on management of water resources. The other areas of vital interest to the Society in the early years were nutrition, proteins, enzymes, applied microbiology, preventive medicines and the development of high quality proteins from indigenous plant sources.
    [Show full text]
  • Activation of Multiple Signalling Pathways by P152lp53 Mutant Reveals New Gain-Of-Function Implicating Tumorigenesis
    bioRxiv preprint doi: https://doi.org/10.1101/475293; this version posted November 20, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Activation of Multiple Signalling Pathways by P152Lp53 Mutant Reveals New Gain-of-function Implicating Tumorigenesis Siddharth Singh1*, Manoj Kumar1*&, Sanjeev Kumar2*, Shrinka Sen1, Pawan Upadhyay3, Naveen M2, Vivek S. Tomar 4, Amit Dutt3 and Tapas K. Kundu1 1Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru-560 064, India 2BioCOS Life Sciences Pvt. Ltd. Bengaluru, India 3 Integrated Cancer Genomics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Center, Navi Mumbai, India 4Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru-560 012, India. & Present address: School of Biological and Environmental Sciences,Faculty of Basic Sciences, Shoolini University, Solan, Himachal Pradesh, India *Authors contributed equally to this manuscript Conflict of interest: The authors declare no potential conflicts of interest. Significance: This study for the first time carried out extensive biochemical and functional characterization of P152Lp53 and established it as a new Gain-of-function mutant which is conformationally altered. Corresponding author: Prof. Tapas K. Kundu, Transcription and Disease Laboratory, Molecular and Genetics Unit, JNCASR, Jakkur P.O., Bengaluru-560064, India. Ph: 91-80-22082840/2841 Email: [email protected] Running Title: A Gain-of-function mutant p53 (P152L) Keywords: DNA Binding, p53 tetramerization, P152L, Tumor suppressor, Carcinogenesis 1 bioRxiv preprint doi: https://doi.org/10.1101/475293; this version posted November 20, 2018.
    [Show full text]
  • CRP-Ongoing Projects Data.Pdf
    Project Indian PI First Indian PI Last French PI First French PI last S.No. Title of the project Indian Institution City French Institution City No Name Name Name Name Studying the role of rpoN, the INRA Laboratoire des Castanet 4800- alternative sigma factor, in the Prof. Suvendra 1 Ray Tezpur University Tezpur Dr. Stéphane Genin Interactions Plantes Micro- Tolosan B1 pathogenicity of R. solanacearum, the Kumar organisms- Cedex causal agent of bacterial wilt in plants National Centre for Biological INSERM (Institut National de la Muscle SC self-renewal: A stressful Sciences, TIFR, Institute for 2 5003-1 Prof. Jyotsna Dhawan Bangalore Dr Ana FERREIRO Santé et la Recherche Paris matter? Stem Cell Biology and Médicale) Regenerative Medicine Advanced Computational Models to Indian Institute of Science Mohanpur, Institut de Recherches en 3 5004-1 Facilitate Solar Activity and Space Dr. Dibyendu Nandi Dr. Laurène JOUVE Toulouse Education and Research, Kolkata Astrophysique et Planétologie Weather Predictions Influence of the Resorcin[4]arene on Tiruchirappali 4 5005-1 Dr. R. Ramesh Bharathidasan University Dr. D. Sémeril Université de Strasbourg Strasbourg the Catalytic Outcomes , Tamil Nadu Design and synthesis of new C1‐ ECPM University of symmetric biaryl‐based ligands and Strasbourg, UMR 5 5005-2 Dr. Pradeep Kumar National Chemical Laboratory Pune Dr. Frédéric LEROUX Strasbourg catalysts and their evaluation in 7509/CNRS/ECPM – Chimie asymmetric catalytic reactions Moléculaire The Immuno-Psychiatry in South India Jawaharlal Institute of Study (IPS): Immunogenetic and INSERM U 942, Saint Louis 6 5103-1 Dr. Vir Singh Negi Postgraduate Medical Pondicherry Dr. Ryad Tamouza Paris Immuno-phenotype Characterization Hospital Education and Research of Major Psychoses TIFR National Centre for (CSGA) UMR- 7 5103-2 Olfactory Modulation of Insect Flight Prof.
    [Show full text]
  • 37Th IACR Convention
    37th IACR Convention From Cancer Biology to Precision Oncology: Challenges and Considerations Jointly Organized by Indian Association of Cancer Research & Bose Institute, National Institute of Biomedical Genomics, Indian Statistical Institute, Indian Institute of Chemical Biology, IIT-KGP, IPGMR, Saha Institute of Nuclear Physics, IISER-Kolkata, Chittaranjan National Cancer Institute, Saroj Gupta Cancer Centre, Burdwan University, University of Calcutta 23rd- 25th February, 2018, Bose Institute, Unified Academic Campus, EN block, Salt Lake, Kolkata Programme 23rd February, 2018 08.30 am-09.30 am Registration 09.30 am-10.00 am Inauguration (Auditorium) SESSION 1 Chair: Prof. Partha P. Majumder 10:00am - 11:00 am IACR Oration & Institute Day Address of the National Institute of Biomedical Genomics, Kalyani Using Genomics to Inform Care of Patients with Cancer Peter Campbell 11:00am-11:30am Mapp Tea Break SESSION 2 Chair: Prof. Siddhartha Roy and Prof. Samit Chattopadhyay 11:30am – 11:50am INOVATe: a step closer to precision treatment for women with epithelial ovarian cancer Anna deFazio 1 11:50am -12:10 pm Genetic landscape of Indian gliomas: Defective neuroactive ligand-receptor interaction pathway identifies glioblastoma with poor survival Kumaravel Somasundaram 12:10pm-12:30pm Axonal Guidance Proteins in Tumorigenesis: Role of Genetic Status of KRAS and TGF-b1 Signaling Pathway Debabrata (Dev) Mukhopadhyay 12.30 pm-1.30 pm Poster Session (Hallway) [ Poster numbers 1-25 + 25 posters for Baxi and Kulkarni Awards] 1.30 pm-2.30 pm Lunch Invited Lecture (Hall-A; 2.30 pm – 5.10 pm) SESSION 3 Chair: Dr. Kunal Ray & Dr. Arindam Maitra (AGILENT sponsored session) 2.30 pm - 2.50 pm IL-01.
    [Show full text]