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14th FAOBMB Congress and 84th Annual Meeting of SBC (I)

Current Excitements in Biochemistry and Molecular for Agriculture and Medicine

Centre for Cellular and Molecular Biology, Hyderabad, India 27 – 30 November 2015

Programme

Time (h) Day 1; Friday, 27 November 2015 11.00 - 13.00 Registration 12.30 - 13.30 Lunch 13.30 – 14.00 Inauguration 14.00 – 14.05 Announcement of President Elect, FAOBMB Plenary Lecture 1: Kanury V S Rao, India (Takashi Murachi Memorial Lecture) Deciphering the host-pathogen interplay in human macrophages infected with 14.05 - 14.45 Mycobacterium tuberculosis Chairperson: 14.45 - 15.25 Kiyoshi Fukui, Japan Plenary Lecture 2: , India (Kunio Yagi Lecture) Towards a Blueprint for Building the Brain 15.25 - 15.55 Tea/Coffee

Protein Folding and Disease Developmental Biology Epigenetics and miRNA 16.00 - 18.00 Chairperson: Masatsune Kainosho, Japan Chairperson: Polani B. Seshagiri, India Chairperson: K. Satyamoorthy, India

L S. Shashidhara, India Manajit Hayer-Hartl, Germany Rakesh K. Mishra, India A comparative genomic analysis of targets of 16.00 - 16.30 The complex chaperone machineries for the Functional Compartmentalization of the Hox protein Ultrabithorax amongst distant folding and assembly of RuBisCO Genome and Epigenetic Regulation of Genes insect species: new insights into evolution of

halteres in Drosophila Subramaniam Ganesh, India Tapas Kundu, India Kunihiro Kuwajima, Japan 16.30 - 17.00 Mitochondrial homeostasis and Lysine Acetylation and Arginine Methylation of The problem of protein folding neurodegeneration: Insight from Lafora Histones are critical for Neural Differentiation

disease and Memory Jayant Udgaonkar, India Surendra Ghaskadbi, India 17.00 - 17.30 Sanjeev Khosla, India Mechanism of misfolding of the prion protein Identification and characterization of BMP

inhibitors Noggin and Gremlin from Hydra Zengyi Chang, China Ritu Kulshreshtha, India Anu Bashamboo, France Understanding the Unusual Biological Function Hypoxic Regulation of : Implications Cellular Models to Understand Cell Fate 17.30 - 18.00 and Action Mechanism of the acid resistant for Biology Choice During Human Sex-Determination molecular chaperone HdeA: from in vitro to in

vivo SBC(I) Award: B. J. Rao, India (Prof. M. Shadakshara Swamy Endowment Lecture Award) 18.05 - 18.35 Chairperson: Genome Dynamics: Chromosome Territories & Replication Forks are dynamically Ch. Mohan Rao, India regulated in mammalian genomes 18.35 – 19.30 Poster / EC meeting of SBC(I) 20.00 - 21.00 Dinner 14th FAOBMB Congress and 84th Annual Meeting of SBC (I)

Time (h) Day 2; Saturday, 28 November 2015

Plenary Lecture 3: Ulrich Hartl, Germany (IUBMB Lecture) 09.15 - 09.55 Molecular Chaperones: Guardians of the Proteome Chairperson: 09.55 - 10.35 Plenary Lecture 4: David Craik, Australia (FAOBMB Award for Research Excellence) Andrew H.-J. Wang, Taiwan Discovery and applications of cyclic peptides in drug design

Agriculture Cardiovascular and Metabolic Diseases Infection and Disease 10.35 - 13.30 Chairperson: Samit Adhya, India Chairperson: K. Muniyappa, India Chairperson: Hansel Fletcher, USA

Aruni Wilson, USA B. K. S. Sastry, India 10.35 - 11.05 Appa Rao Podile, India Community microbial consortia of yet-un- Clinical perspective of translational research in Chitooligosaccharides and immunity in plants cluturable bacteria and their implications in cardiovascular diseases health and disease

Joon Kim, Korea Ramesh V. Sonti, India Shantanu Sengupta, India Ribosomal proteins play important roles in DNA 11.05 - 11.35 Induction and suppression of host innate immunity Understanding Coronary Artery Disease in India repair, cancer and Candida infection with in plant-pathogen interactions using multilayer–omics analysis respect to cellular stress

11.35 - 12.00 Tea/Coffee Break

Leann Tilley, Australia Rajeev K. Varshney, India P. S. Dhandapany, USA 12.00 - 12.30 Targeting the Cell Stress Response of Next generation for crop improvement- Cardiomyopathies:From Genes to Therapies Plasmodium Falciparum to Overcome some examples in chickpea Artemisinin Resistance

Ajit Kumar Shasany, India Nitish R. Mahapatra, India Kim Chu-Young, Singapore Channelling of intermediates for secondary Chromogranin A Gly364ser variant profoundly 12.30 - 13.00 Structural Biology of Enzymes Involved in metabolite biosynthesis: essential for metabolic alters the risk for hypertension in human NaturalProduct Antibiotic Biosynthesis engineering? populations via modulation of endothelial nitric

oxide levels

*Veena S. Anil, *M. Balasubramanyam , India 13.00 - 13.15 Inherent and induced mechanisms of Late Blight Excitements versus Deliverables of Omics resistance in potato crop Apurba Kumar Sau, India Advancements in Diabetes Structural and Functional Insights into the Regulation of Helicobacter pylori Arginase *Sharmila Chattopadhyay, India *Shakila Srikumar, Malaysia Activity by an Evolutionary Non-conserved Motif 13.15 - 13.30 Interaction of Glutathione with ethylene to control Hyperhomocysteinemia and Cardiovascular necrotrophic fungal infection in crop plant Disease: The Process and Prevention

13.30 - 14.45 Lunch/Poster

SBC(I) Award: G. Suresh Kumar, India (C. R. Krishna Murti Award) Nucleic acid interaction of small molecules: From lac repressor protein fragments, 14.45 - 15.15 mitomycins to natural alkaloids Chairperson: 15.15 - 15.45 Ch. Mohan Rao, India SBC(I) Award: Subrata Chattopadhyay, India (P. B. Rama Rao Memorial Award) A Tale of Three Molecular Sisters

Chromosome and Reproductive Biology Cancer Biology IUBMB Education Session 3.50 - 18.45 Chairperson: Subramaniam Ganesh, India Chairperson: LS. Shashidhara, India Chairperson: Koh Siok Im

Polani B. Seshagiri, India P. Kondaiah, India D. Balasubramanian, India 15.50 - 16.20 Cellular and Molecular Control of Blastocyst Role of Insulin like Growth Factor Binding Popularization of Science as an

Hatching Protien-2 in the pathogenesis of additional/alternate career

Rana P. Singh, India Tatsuo Fukagawa, Japan Martin Stone, Australia 16.20 - 16.50 An adjuvant for enhancing radiotherapeutic Molecular architecture of vertebrate centromeres Alternative career paths efficacy in prostate cancer

16.50 - 17.15 Tea/Coffee Break

Kumaravel Somasundaram, India Gracia Fe B Yu, Philippines 17.15 - 17.45 Rima Dada, India Tumor-stroma interactions in glioblastoma: From basic research to livelihood: a Ph.D as Sperm DNA damage: Clinical Implications Identification of a novel angiogenic factor social entrepreneur

Sagar Sengupta, India Hansel Fletcher, USA 17.45 - 18.15 Rajender Singh, India The role of RECQL4 helicase, the protein mutated Diversity in the biomedical workforce – future in Rothmund Thomson Syndrome, in anticipated career opportunities mitochondrial functions

Suresh Mathivanan, Australia Deepak Modi, India Intercellular transfer of mutant β-catenin via 18.15 - 18.45 HOXA10 Functions in Endometrial Implantation - Discussion exosomes activates Wnt signalling pathway in the and Decidualization tumor microenvironment

18.45 - 19.45 General Body Meeting of SBC(I)

19.30 - 20.15 Cultural Programme

20.30 - 21.30 Dinner

* Short presentation (15 min.)

14th FAOBMB Congress and 84th Annual Meeting of SBC (I)

Time (h) Day 3; Sunday, 29 November 2015

Plenary Lecture 5: Giulio Superti-Furga, Austria (FEBS Lecture) Chairperson: 09.25 - 10.05 Molecular networks, drug action and genome-informed medicine Ulrich Hartl, Germany

DNA Damage, Recombination and Repair Emerging Technologies Young Scientist Award Session 10.10 - 13.10 Chairperson: Tatsuo Fukagawa, Japan Chairperson: Kumaravel Somasundaram, India Chairperson: Sheila Nathan, Malaysia

Urmi Dhagat, Australia Erich Gnaiger, Austria K. Muniyappa, India The molecular basis of Interleukin-3 receptor 10.10 - 10.40 Differences in mitochondrial function in brain Molecular Insights into Meiotic Chromosome signaling and strategies for targeting IL-3 microsamples in health and disease revealed by Pairing from Single Molecule Analysis activity in Acute Myeloid Leukaemia high-resolution respirometry

Ashok Gopinath, Singapore Victor Anggono, Australia Anindya Roy, India 10.40 - 11.10 Recent Progresses in Genomics and their Molecular Mechanisms of AMPA Receptor RecA protein stimulates demethylation of DNA Applications in Oncology Trafficking

11.10 - 11.40 Tea/Coffee Break

Manas Kumar Santra, India Oral Presentation from Selected Abstracts (6) 11.40 - 12.10 Dedicated DNA damage checkpoint protein Stephen Rudd, Singapore FBXO31 facilitates -mediated growth arrest Sathish Kumar Ramalingam, India following genotoxic stresses Next Generation DNA Barcoding for the Authentication of Herbal Admixtures Jay Fox, USA Akira Shinohara, Japan Proteomic Analysis of Human Blister Fluids B. Padmanabhan, India 12.10 - 12.40 Prophase pathway for removal of a meiosis- Following Envenomation by Three Snake Structure based drug discovery of small molecules for the BRD2 bromodomain specific cohesin from arms of chromosomes Species: Differential Markers for Venom associated with cancer and neurodegenerative duringlate prophase I of meiosis Mechanisms of Action and Potential for diseases Personalized Therapeutic Intervention

Kartik Sunagar, India Mrinal Kanti Bhattacharya, India Prathap Naidu, India The rise and fall of an evolutionary innovation The non-redundant homologous recombination 12.40 - 13.10 Ion S5™ and Ion S5™ XL Next-Generation pathway of parasites is essential for Sequencing Systems for Targeted Sequencing DNA double strand break repair

13.10 - 14.25 Lunch /Poster

Plenary Lecture 6: Sathees C. Raghavan, India (FAOBMB Lecture) 14.25 - 15.05 Homology and Enzymatic Requirements of an Alternate, Microhomology Dependent NHEJ and its Relevance in Generation of DNA Deletions and Rearrangements Chairperson: Plenary Lecture 7: Tej P. Singh (GN. Ramachandran Lecture) David Craik, Australia 15.05 - 15.45 Structural basis of action of peptidoglycan recognition proteins and their possible applications as protein antibiotics

15:45 - 16.15 Tea/Coffee Break

Structural Biology Computational and System Biology Mitochondria in Health and Disease 16.15 - 18.15 Chairperson: Manajit Hartl, Germany Chairperson: Jay Fox, USA Chairperson: Keshav K. Singh

Masatsune Kainosho, Japan Alok Bhattacharya, India Samit Adhya, India 16.15 - 16.45 Recent Progress in the Selective SAIL Method Whole Genome based analysis of Bacterial Mitochondrion-regulated mTORC activation of for Studying Structures and Dynamics of Evolution satellite cell proliferation: role of microRNAs Proteins and Protein Complexes

Yau-Huei Wei, Taiwan Vinod Scaria, India Dysregulation of Ca2+ Homeostasis Caused by 16.45 - 17.15 R. Sankaranarayanan, India Personal Genomes to precision Medicine Dysfunction of Mitochondria-associated ER

membranes Contributes to Insulin Insensitivity

and Diabetes

R. Manjunatha Kini, Singapore (Y) Patrick D’Silva, India 17.15 - 17.45 Design of a Novel, Highly Selective Factor XIa Uncovering the role of ISCU protein in the Fe/S Leelavati Narlikar, India Inhibitor from Banded Krait (Bungarus cluster biogenesis: Implications in the fasciatus) Venom development of mitochondrial myopathy

Shailza Singh, India Paradoxical components in Biological circuits Naresh B.V. Sepuri, India K.V.R. Chary, India 17.45 - 18.15 and Negative Autoregulation of Transcriptional Import of Cytosolic tRNAs into Mammalian βγ-crystallins: Intrinsic Order and Disorder Factors: A Systems-theoretic model in Mitochondria Leishmaniasis

18.30 - 19.30 Cultural Programme

20.00 - 21.00 Dinner

14th FAOBMB Congress and 84th Annual Meeting of SBC (I)

Time (h) Day 4; Monday, 30 November 2015

Plenary Lecture 8: Keshav K. Singh, USA (Jisnuson Svasti Lecture) Chairperson: 09.25 - 10.05 MipiGenetic and MipiGenomic: Integration of mitochondria-induced cellular mayhem Yau-Huei Wei, Taiwan at epigenetic and genetic level

Ancient and Traditional Medicine in Modern Alternate Model System for Human Disease Evolutionary Biology 10.10 - 13.10 Context Chairperson: William Y Tsang, Canada Chairperson: G. Kumaramanickavel, India Chairperson: P. Kondaiah, India

John Mercer, USA Bhusan Patwardhan, India Marie Allen, Sweden 10.10 - 10.40 A multilevel approach to inherited sarcomeric Ancient and Traditional Medicine in Modern Novel tools for Forensic DNA testing

cardiomyopathies Context

Sridhar Sivasubbu, India K. Satyamoorthy, India B. Venkatesh, Singapore Non-Protein Coding RNA Based Regulation of Prakriti Relationship to DNA Methylation 10.40 - 11.10 The slow -evolving genome of elephant shark: Vascular Development in Zebrafish Differences for Phenotype Descriptions a valuable reference genome

11.10 - 11.40 Tea/Coffee Break

C. Sachidanandan, India Gyaneshwer Chaubey, Estonia 11.40 - 12.10 Padma Venkat, India From Fish to Men : drugging Iron Regulatory Migration, admixture and assimilation: case of

Disorders Jewish and Parsi populations in India

Chiranjib Chakraborty, South Korea Bhavana Prasher, India Kamani Tennekoon, Sri Lanka 12.10 - 12.40 Zebrafish model: an Absolute Animal Model to Ayurgenomics: Exploring the genomic basis of Maternal lineages of major ethnic groups in Sri Study in vitro Drug Discovery, Different Diseases Ayurveda principles for development of predictive Lanka including the Vedda population Mechanism and miRNA Research and personalized medicine

Mitali Mukerjee, India Heui Soo Kim, South Korea Upendra Nongthomba, India Ayurgenomics : An integrative genomics 12.40 - 13.10 Alternative Splicing and Transcriptional Indirect flight muscles of Drosophila as a model approach for partitioning the human genome Regulation of Functional Genes by system to study myogenesis and myopathies variability for stratified medicine Transposable Elements

13.10 - 14.25 Lunch/Poster

Plenary Lecture 9: Ikuro Abe, Japan (Osamu Hayaishi Lecture) Chairperson: 14.25 - 15.05 Engineered Biosynthesis of Medicinal Natural Products Tej P. Singh, India

Neurobiology 15.10 - 16.40 Eye Disease Nanotechnology and Stem Cell Chairperson: Chiranjib Chakraborty, South Chairperson: Kamani Tennekoon, Sri Lanka Chairperson: John Mercer, USA Korea

Rama Shanker Verma, India Kiyoshi Fukui, Japan William Y Tsang, Canada Hybrid Tissue Engineered scaffold for Fabrication Chiral Science and Pathophysiology of Amino 15.10 - 15.40 Characterization of NPHP5, A Ciliary Protein of a Bioprosthetic Heart Valve Acid Metabolism: regulation of human D-amino Mutated in Eye Disease acid oxidase gene expression and implication

for human psychiatric disorders

G. Kumaramanickavel, India G. Venkatasubramanian, India Ambarish Ghosh, India 15.40 - 16.10 Ophthalmic Genomics: Current Trends and its Translational Implications of Neuroimmune - Biological applications with magnetic Applications in Clinical Practice Neuroplastic Interactions in Schizophrenia: nanoswimmers Insights from Imaging Genetics

Ramakrishnan Kannan, India P. Sundaresan, India Cellular pathogenesis of Spatacsin and 16.10 - 16.40 George Thomas, India Ocular Disease Gene discovery Spastizin in autosomal recessive (AR) hereditary spastic paraplegia (HSP)

16.40 – 17.10 Tea/Coffee Break

17.10 - 18.00 Closing Session