Date:-11/0812011
To, Member SecretarY' Climate Change' 3'o Floor,Ministryof Environment,Forest & JorBagh Road, New Delhi-110 003.
Kind Attention: Shri S'K'Srivastava
lA- | | ( | I A- J'LLOILI 2s 1/20 17- ) Ref No. lA/GJl I N D2l6 4s64I 2Ot7,
Sub: Resubmission of ProPosal
Dear Sir, committee on 28'n July'2017' our proposal Appraisal Agenda-item rist should be in different format' g We have revi rn. o:;[.;j;n
Feasibility Report' we request you to grant us we have also changed the table in Form I and Pre TOR.
Thanking you, Yours faithfullY,
FOT IWS.JAY JALARAM ENTERPRISE
AUTHORIZED SIGNATORY
.Nl {n} nr -z+ 02/02 clDcEstate, Near Asian Paint Chowkdy, Ankleshwar 393002
FORM – 1 (I) BASIC INFORMATION 1. Name of the project/s: M/s. Jay Jalaram Enterprise 2. Location / site alternative under Plot No:-A-1/2402/02, consideration G.I.D.C., Ankleshwar-393002 Dist.Bharuch,Gujarat. 3. Size of the project* List of Products is attached as ANNEXURE 2 4. Expected Cost of the project Rs:-325 lacs 5. Contact Information List of directors is attached as ANNEXURE -3 6. E-mail [email protected] Telephone No. (M)-9909030476 7. Screening Category 5(f)-A(Due to the absence of SEAC committee we have considered our project as “A-Category” Project. *Capacity corresponding to sectoral activity (such as production capacity for manufacturing, mining lease area and production capacity for mineral production, area for mineral exploration, length for linear transport infrastructure, generation capacity for power generation etc.,)
(II) ACTIVITY 1. Construction, operation or decommissioning of the Project involving actions, which will cause physical changes in the locality (topography, land use, changes in water bodies, etc.) Sr. Information / checklist Yes / Details thereof (with approximate No. conformation. No. quantities/ rates, wherever possible) with source of information data. 1.1 Permanent or temporary change in land No Proposed Expansion is within existing use, land cover or topography plot. including increase in intensity of land use (with respect to local land use plan.) 1.2 Clearance of existing land, vegetation No Plots are already marked by GIDC and buildings? Estate. 1.3 Creation of new land uses. No The project activity will be carried out in industrial plot so there will be no need to utilize of any new land. 1.4 Pre-construction investigations e.g. No As the proposed expansion is within the bore house, soil testing? existing premises. 1.5 Construction works? Yes Construction work will be carried out as per plant design. 1.6 Demolition works? No Not Applicable
1 M/s.JAY JALARAM ENTERPRISE
1.7 Temporary sites used for construction No Local workers will be employed for works or housing of construction construction work. So there will be no workers? requirement of temporary housing for workers at site. 1.8 Above ground buildings, structures or Yes Plant Layout is attached as earthworks including linear structures, ANNEXURE 4 cut and fill or excavations. 1.9 Underground works including mining No No such underground activity will be or tunneling? carried out. 1.10 Reclamation works? No Not required. 1.11 Dredging? No Not required. 1.12 Offshore structures? No Not required. 1.13 Production and manufacturing Yes Proposed product & its capacity is processes? attached as ANNEXURE- 2. Raw Material list with product is attached as ANNEXURE-5. Manufacturing Process is attached as ANNEXURE -6. 1.14 Facilities for storage of goods or Yes Odorous and Hazardous materials will materials? be stored in closed containers. Proper facility for storage of raw material and finished goods will be provided in the unit. 1.15 Facilities for treatment or disposal of Yes Unit is member of CETP-ETL for solid waste or liquid effluents? effluent discharge. The Unit is a member of approved TSDF for solid waste disposal. Effluent treatment scheme and ETP component is attached as ANNEXURE-7 1.16 Facilities for long term housing of No Not required. Local people will be operational workers? recruited during operation. 1.17 New road, rail or sea traffic during No The site is well connected to roadway. construction or operation? No new road, rail or sea traffic required. Movement of construction material only by existing road of industrial estate. 1.18 New road, rail, air waterborne or other No Not Applicable transport infrastructure including new or altered routes and stations, ports, airports etc? 1.19 Closure or diversion of existing No Proposed project is located in Notified transport routes or infrastructure industrial area and there will be no leading to changes in traffic closure or diversion of existing transport movements? routes or infrastructure. 1.20 New or diverted transmission lines or No There will be no such change caused pipelines? due to the proposed project. 1.21 Impoundment, damming, culverting, No Not Applicable realignment or other changes to the
2 M/s.JAY JALARAM ENTERPRISE
hydrology of watercourses or aquifers? 1.22 Stream crossing? No No such activity is involved in the proposed project. 1.23 Abstraction or transfers of water form No No such activity will be involved. The ground or surface waters? unit will use water from GIDC, Ankleshwar during construction and operational phase. 1.24 Changes in water bodies or the land No There is no change in water bodies or surface affecting drainage or run-off? the land surface affecting drainage or run- off as proposed project is in notified industrial estate. 1.25 Transport of personnel or materials for Yes Existing infrastructure facilities will be construction, operation or utilized for the transport of personnel/ decommissioning? materials for expansion project. 1.26 Long-term dismantling or No No such activity is involved in the decommissioning or restoration works? proposed project. 1.27 Ongoing activity during No There will be no decommissioning decommissioning which could have an activity for the proposed project. impact on the environment? 1.28 Influx of people to an area in either No Local man power will be employed. Temporarily or permanently? 1.29 Introduction of alien species? No ------1.30 Loss of native species or genetic No ------diversity? 1.31 Any other actions? No ------2. Use of Natural resources for construction or operation of the Project (such as land, water, materials or energy, especially any resources which are non-renewable or in short supply): Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 2.1 Land especially undeveloped or No Proposed project is located in Notified agricultural land (ha) Industrial Area, GIDC Estate. 2.2 Water (expected source & competing Yes Details of Water and Waste Water users) unit: KL/Day Generation are attached as ANNEXURE 8. 2.3 Minerals (MT) Yes For construction: Minor minerals like manufactured sand, Grit and pebbles will be used. 2.4 Construction material – stone, Yes Material Qty in Source aggregates, sand / soil (expected source MT – MT) Cement 150 From: Local Sand 300
3 M/s.JAY JALARAM ENTERPRISE
Granules 450 Steel 30 2.5 Forests and timber (source - MT) No No forest and timber products will be used. 2.6 Energy including electricity and fuels Yes Detail of Energy and Fuel consumption (source, competing users) Unit: fuel is attached as ANNEXURE – 9. (MT),energy (MW) 2.7 Any other natural resources (use No No other natural resources will be used. appropriate standard units) 3. Use, storage, transport, handling or production of substances or materials, which could be harmful to human health or the environment or raise concerns about actual or perceived risks to human health. Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 3.1 Use of substances or materials, which Yes List of hazardous chemicals are:- are hazardous (as per MSIHC rules) to Pyridine human health or the environment Carbon disulphide (flora, fauna, and water supplies) Hydrochloric acid Sulphuric acid Acetic anhydride Thionyl chloride 3.2 Changes in occurrence of disease or No Not Applicable affect disease vectors (e.g. insect or water borne diseases) 3.3 Affect the welfare of people e.g. by Yes The project will benefit the people living changing living conditions? in the neighboring areas by providing them with direct and indirect employment opportunities associated with the construction and operation of the proposed project. 3.4 Vulnerable groups of people who could No Not Applicable be affected by the project e.g. hospital patients, children, the elderly etc. 3.5 Any other causes. No No other cause. 4. Production of solid wastes during construction or operation or decommissioning (MT/month). Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 4.1 Spoil, overburden or mine waste. No No mine waste / mine activity. No Over burden soil. The excavated material, during the foundation will be used for filling.
4 M/s.JAY JALARAM ENTERPRISE
4.2 Municipal waste (domestic and or Yes Office and Canteen waste will be commercial wastes) collected and disposed as per MSW rules. 4.3 Hazardous wastes (as per Hazardous Yes List of Hazardous Waste is enclosed as Waste Management Rules) ANNEXURE- 10. 4.4 Other industrial process wastes No No industrial process waste will be generated. 4.5 Surplus product No No surplus product will be produced. 4.6 Sewage sludge or other sludge from Yes Sewage sludge will be generated and effluent treatment. sludge generated through ETP will be sent to TSDF site for disposal. 4.7 Construction or demolition wastes No Not Applicable 4.8 Redundant machinery or equipment. No Not Applicable 4.9 Contaminated soils or other materials. No Not Applicable 4.10 Agricultural waste. No No agriculture waste will be generated. 4.11 Other solid wastes. No No other solid waste will be generated from the project. 5. Release of pollutants or any hazardous, toxic or noxious substances to air (Kg/hr) Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 5.1 Emissions from combustion of fossil Yes -There may be an emission due to fuels from stationary or mobile transportation. But it will be managed by sources. following steps. 1) Proper maintenance of vehicles and machines. 2) PUC certified vehicles will be allowed for transportation. Details of Flue Gas Emission are attached as ANNEXURE-11. 5.2 Emissions from production processes. Yes Details of Process Emission are attached as ANNEXURE-12. 5.3 Emissions from materials handling No Adequate measures will be taken to including storage or transport. control emissions from material handling including storage or transport. 5.4 Emissions from construction activities Yes Temporary in nature, which may including plant and equipment. originate during construction of building or roads, this will be taken care by proper dust suppression by sprinkling of water and providing PPE to all workers. 5.5 Dust or odours from handling of Yes The project may cause rise in dust levels materials including construction during construction phase. Precautions materials, sewage and waste. would be taken to reduce dust generation during construction phase. Water sprinkling will be done at regular
5 M/s.JAY JALARAM ENTERPRISE
intervals to reduce the air borne dust 5.6 Emissions from incineration of waste. No Not Applicable 5.7 Emissions from burning of waste in No No burning activity will be carried out open air (e.g. slash materials, in the unit. construction debris) 5.8 Emission from any other sources. No No other emissions from any other source. 6. Generation of Noise and Vibration, and Emissions of Light and Heat: Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 6.1 From operation of equipment e.g. Yes Maximum noise levels expected will be engines, Ventilation plant, crushers. less than 75 dbA in day time at plant boundary. The DG sets will be of CPCB specifications. 6.2 From industrial or similar processes. No Adequate measures will be taken by the unit. 6.3 From construction or demolition. No Adequate measures will be taken by the unit. 6.4 From blasting or piling. No No blasting or piling operation required. 6.5 From construction or operational Yes There will be temporary increase in traffic. traffic during construction stage. As the material is available locally and not requires any stagnation of material or vehicle stagnation. 6.6 From lighting or cooling systems. No Not Applicable. 6.7 From any other sources. No No emission from any other sources. 7. Risks of contamination of land or water from releases of pollutants into the ground or into sewers, surface waters, groundwater, coastal waters or the sea: Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 7.1 From handling, storage, use or spillage No All necessary safety measures will be of hazardous materials. provided for handling, spillage and storage of hazardous chemicals. 7.2 From discharge of sewage or other No No treated effluent will be disposed on effluents to water or the land (expected land. Treated sewage effluent will be mode and place of discharge) partially used for gardening purpose. 7.3 By deposition of pollutants emitted to No Not Applicable air into the land or into water. 7.4 From any other sources. No Nil 7.5 Is there a risk of long term build up of No No pollutants will be built up in the pollutants in the environment from Environment. Therefore no risk from these sources? any sources. 8. Risk of accidents during construction or operation of the Project, which could affect
6 M/s.JAY JALARAM ENTERPRISE
human health or the environment. Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 8.1 From explosions, spillages, fires etc. Yes There will be chances of risk of accident from storage, handling, use or from the proposed activity. Adequate production of hazardous substances. control measures will be provided. Proper on site and off site emergency plans will be prepared. Unit will be carried out each and every activity in a safety manner. 8.2 From any other causes No No risk of accident from any other causes. Adequate precautionary measure will be taken by the unit. 8.3 Could the project be affected by natural Yes However, the unit will be designed and disasters causing environmental constructed considering the impact of damage (e.g. floods, earthquakes, floods, earthquakes etc. landslides, cloudburst etc)? 9. Factors which should be considered (such as consequential development) which could lead to environmental effects or the potential for cumulative impacts with other existing or planned activities in the locality. Sr. Information / Checklist Yes / Details thereof (with approximate No. conformation. No. quantities / rates, wherever possible) with source of information data. 9.1 Lead to development of supporting localities, ancillary development or development stimulated by the project which could have impact on the environment e.g.: • Supporting infrastructure (roads, Yes Will lead to development of nearby power supply, waste or waste water areas by generating employment and treatment, etc.) providing infrastructure. • housing development • extractive industries • supply industries • other 9.2 Lead to after – use of the site, which No There will be no significant impact on could have an impact on the environment. environment. 9.3 Set a precedent for later developments. No The Notified area is already well developed. 9.4 Have a cumulative effect due to No There will be no cumulative effect from proximity to other existing or planned the proposed project. projects with similar effects. (III) ENVIRONMENTAL SENSITIVITY. Sr. Area. Name / Aerial distance (within 15 km.)
7 M/s.JAY JALARAM ENTERPRISE
No. Identity Proposed project location boundary. 1. Areas protected under international No None within 15 km Aerial distance conventions, national or local from proposed plant site. legislation for their ecological, landscape, cultural or other related value. 2. Areas which are important or No None within 15 km Aerial distance sensitive for ecological reasons - from proposed plant site. Wetlands, watercourses or other water bodies, coastal zone, biospheres, mountains, forests. 3. Areas used by protected, important or No None within 15 km Aerial distance sensitive species of flora or fauna for from proposed plant site. breeding, nesting, foraging, resting, over wintering, migration. 4. Inland, coastal, marine or No None within 15 km Aerial distance underground waters from proposed plant site. 5. State, National boundaries. No None within 15 km Aerial distance from proposed plant site. 6. Routes or facilities used by the public No None within 15 km Aerial distance for access to recreation or other from proposed plant site. tourist, pilgrim areas. 7. Defense installations. No None within 15 km Aerial distance from proposed plant site. 8. Densely populated or built – up area. Bharuch Approximate distance to Bharuch is 15 and Km. Anklesh war city 9. Areas occupied by sensitive man- Yes Academic institutes and hospitals are made land uses (hospitals, schools, existing within 5 km radius from the places of worship, community project site. facilities) 10. Areas containing important, high No Nil quality or scare resources (ground water, surface resources, forestry, agriculture, fisheries, tourism, minerals) 11. Areas already subjected to pollution No Nil or Environmental damage. (those where existing legal environmental standards are exceeded) 12. Areas susceptible to natural hazard No Nil which could cause the project to present environmental problems (earthquakes, subsidence, landslides,
8 M/s.JAY JALARAM ENTERPRISE
erosion, flooding or extreme or adverse climatic conditions)
“ I hereby given undertaking that the data and information given in the application and enclosures are true to my best knowledge and belief and I am aware that if any part of the data and information submitted is found to false or misleading at any stage, the project will be rejected and clearance give, if any to the project will be revoked at our risk and cost”.
Date: Place: Signature of the applicant With full Name and Full address (Project Proponent/ Authorized Signatory)
NOTE: 1. The projects involving clearance under Coastal Regulation Zone Notification, 1991 shall submit with the application a C.R.Z map duly demarcated by one of the authorized agencies, showing the project activities, w.r.t. C.R.Z (at the stage of TOR) and the recommendations of the State Coastal Zone Management Authority (at the stage of EC). Simultaneous action shall also be taken to obtain the requisite clearance under the provisions of the C.R.Z Notification, 1991 for the activities to be located in the CRZ.
2. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals, the project proponent shall submit the map duly authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location and there commendations or comments of the Chief Wildlife Warden thereon (at the stage of EC).
3. All correspondence with the Ministry of Environment & Forest including submission of application for TOR/Environmental Clearance, subsequent clarifications, as may be required from time to time, participation in the EAC Meeting on behalf of the project proponent shall be made by the authorized signatory for the specific project.
9 M/s.JAY JALARAM ENTERPRISE ANNEXURE-1
TERMS OF REFERENCE
TOR prescribed by MoEF & CC for this sector will be taken into account.
ANNEXURE-2
LIST OF PRODUCTS Sr. Product Name Trade Name Existing Proposed Total No. Quantity as Quantity Quantity per CCA MT/Month MT/Month AWH-76585 Valid Up To 25/06/2021 MT/Month GROUP-A API PRODUCTS (Each product not more than 40 MT/Month) 01 Bis(diethylthiocarbamoyl) disulfide Disulfiram 10 30 02 1,8-Diacetoxy-3-carboxyanthraquinone Diacerein 10 30 03 Bis[[( R)-3-carboxy-2- L-Carnitine 15 25 hydroxypropyl]trimethylammonium] L- Tartrate Tartrate 04 2,5-Dihydroxybenzenesulfonic acid Calcium 10 30 calcium salt Dobesilate 05 2,5-Dihydroxybenzenesulfonic acid Ehamsylate 15 25 40 MT Diethylamine salt (Either/or) 06 Valproic acid Valproic acid 15 25 07 (2E)-[(4R)-4-(2,4-dichlorophenyl)-1,3- Luliconazole - 40 dithiolan-2-ylidene]-(1H-imidazole-1- yl)ethanenitrile 08 3-[(2R,3R)-1-(dimethylamino)-2- Tapentadol - 40 methylpentan-3-yl]phenol 09 Five & Six Membered ring heterocyclic ------40 pharmaceuticals derivatives TOTAL (SR No:-1 to 9) (Total production will be 40 MT/Month) 40 MT/Month GROUP-B FOOD AND NEUTRACUTICAL PRODUCTS (Each product not more than 40 MT/Month) ANNEXURE-2
10 L-2,5-Diaminopentanoic acid-L-2- L-Ornithine-L- 15 25 Aminobutanedioic acid Aspartate 11 L-γ-glutamyl-L-cysteinyl-glycine L-Glutathion 15 25 12 (2 R)-2-acetamido-3-sulfanylpropanoic acid N-Acetyl cysteine 15 25 13 Methyl sulphone Monosulphone 10 30 methane 14 2-Aminobutanedioic acid Calcium salt Calcium aspartate 15 25 40 MT 15 Sodium iron (III) ethylene diamine tetra Sodium - 40 (Either/or) acetate Feredetate 16 Calcium salt of 2,6-dioxo-1,2,3,6- Calcium salt of - 40 tetrahydro-pyrimidine-4-carboxylic acid Orotic acid
17 Amino acids, its salts and acetylated ------40 derivatives TOTAL (Sr No:-10 to 17) (Total production will be 40 MT/Month) 40 MT/Month GROUP-C COSMETIC PRODUCTS (Each product not more than 40 MT/Month) 18 2- palmitoyloxymethyl-5-palmitoyloxy-y- Kijic acid 15 25 pyrone Dipalmitate 19 6-palmitoyl-3-keto-L-gulofuranolactone Ascorbyl 10 30 40 MT Palmitate (Either/or) 20 4-t-butyl-4’-methoxy-dibenzoyl methane Avobenzon - 40 21 2-(hydroxymethyl)-6-(4- Arbutin - 40 hydroxyphenoxy)tetrahydro-2H-3,4,5-triol TOTAL(Sr No:-18 to 21) (Total production will be 40 MT/Month) 40 MT/Month GROUP-D API AND DYES INTERMEDIATE PRODUCTS (Each product not more than 40 MT/Month) 22 Barbituric Acid ------15 25 40 MT 23 Bis (2-chloroethyl) amine .HCl ------15 25 (Either/or) 24 1-(4-Methoxy phenyl)Piperazine ------10 30 ANNEXURE-2
25 N-Phenyl Piperazine ------10 30 26 2,3 Dichlorophenylpiperazine ------10 30 27 1,3-Chlorophenyl Piperazine ------10 30 28 Hydroxy ethyl Piperazine ------15 25 29 1-H-1,2,4 triazole ------15 25 30 Methyl-3-Amino crotonate ------15 25 31 Sodium-2-ethyl hexanoate ------10 30 TOTAL (Sr No: - 22 to 31) (Total production will be 40 MT/Month) 40 MT/Month GROUP-E R&D PRODUCT (Each product-2 MT/Month) 32 Inorganic R&D Product ------2 2 MT/Month 33 Organic R&D Product ------2 2 MT/Month TOTAL 4 MT/MONTH TOTAL(Group-A+ Group-B+ Group-C+ Group-D+ Group-E) 164 MT/Month
ANNEXURE-3
LIST OF PARTNERS
Sr. Name of the Partner Designation Address Contact No. No. 1. Mr. PARAS DOSHI PARTNER A-50 GUJARAT 9312214732 APARTMENT, PITAMPURA, NEW DELHI 110034 1. Mr. SHAILEN PARTNER A-34 GUJARAT 9312872110 DOSHI APARTMENT, PITAMPURA, NEW DELHI 110034
36.91 S
PLOT BOUNDARY E W 11.38 6.55
N ETP 4.34 8.79
12.18 4.44
LIQUID TANKS 3.99 70.15 SMT STAFF ROOM
55.72 SMT C
15.82 B
UTILITY BLDG 1 259.23 SMT 319.19 12.43
43.12 10.92 91.22 SMT
RND BUILDING FINISHED PRODUCT STORAGE 168.95
6.00 METER WIDE ROAD WASH RM
21.68 SMT 7.40
3.37 METER WIDE ROAD 3.04 GREEN BELT :
SR.NO. AREA IN SMT.
104.13 A 200.90 B 319.19
PLOT BOUNDARY PLANT 2 PLOT BOUNDARY C 259.23 340.60 SMT D 251.68 E 55.01 TOTAL 1086.01
"JAY JALARAM ENTERPRISE." PLOT NO:-A-1/2402/02, NR. ASIAN PAINT CHOKDI, G.I.D.C.ESTATE, ANKLESHWAR-393002. 82.79 1. TOTAL PLOT AREA 3834.34 SMT
2. GREEN BELT REQD. ( 25% ) 958.59 SMT 1.00 3. GREEN BELT PROVIDED ( < 25% ) 1086.01 SMT
GREEN BELT PROVIDED / TOTAL PLOT AREA 1086.01 / 3834.34 PROVIDED AS PERCENTAGE PLOT 28.32 % 55.01 PLANT 1
D MASTER PLAN : 747.97 SMT
251.68 SMT NO. PARTICULAR COLOUR AREA
5.31 METER WIDE ROAD 1. PLANT 1 747.97 SMT
2. PLANT 2 340.60 SMT
RAW MATERIAL STORAGE 3. RND BUILDING 168.95 SMT 55.01 SMT -
E 4. UTILITY BUILDING 1 55.72 SMT
3.47 5. UTILITY BUILDING 2 91.22 SMT 9.96
6. ETP 28.42 SMT A
5.74 5.74 200.90 SMT
7. STAFF ROOM 70.15 SMT 3.79 8. WASH ROOM 21.68 SMT 12.93 12.93 TOTAL 1524.71 SMT
17.22 GATE GATE PLOT BOUNDARY
PROPOSED PLAN FOR MANUFACTURING OF GENERAL API 12.00 METER WIDE G I D C ROAD "JAY JALARAM ENTERPRISE." PLOT NO:-A-1/2402/02, NR. ASIAN PAINT CHOKDI, G.I.D.C.ESTATE, ANKLESHWAR-393002. DRAWING BY:- SHILPAN NELSON 301, TOWER A, GIRIRAJ GREENS, AJWA NIMETA ROAD, VADODARA - 19 SCALE = 1:100 PH : 9228491527 email : [email protected] DATE = 24-05-2016 DRG.NO.-1 ANNEXURE-5
LIST OF RAW MATERIALS
SR. Name of Product Quantity of Name of Raw MT/MT MT/Month No Product material OF MT/Month PRODUCT PHARMA API PRODUCTS (BULK DRUG) 1. Bis(diethylthiocarbamoyl) 40 Di-Ethyl Amine 0.53 21.2 disulfide Carbon Di-sulphide 0.55 22 Caustic Soda 0.29 11.6 Sodium Nitrite 0.49 19.6 Hydrochloric acid 1.42 36% 56.8 TOTAL 3.28 131.2 2. 1,8-Diacetoxy-3- 40 1,8-Dihydroxy 3- 0.78 carboxyanthraquinone (hydroxymethyl) anthraquinone 31.2 Potassium Hydroxide 0.33 13.2 Hydrogen Peroxide - 0.39 50% 15.6 Hydrochloric acid 0.84 -36% 33.6 Acetic Anyhdride 0.28 11.2 Acetic Acid 0.03 1.2 Sulphuric Acid 0.13 5.2 Dimethyl acetamide 0.05 fresh 2 TOTAL 2.83 113.2
3. Bis[[( R)-3-carboxy-2- 40 3-carboxy-2- hydroxypropyl]trimethyla hydroxypropyl- 0.68 mmonium] L-Tartrate trimethyl 27.2 L-Tartaric acid 0.32 12.8 MeoH fresh 0.04 1.6 TOTAL 1.04 41.6 4. 2,5- 40 2,5 Dihydroxy 0.56 . Dihydroxybenzenesulfoni Benzene 22.4 c acid calcium salt Sulphuric Acid 0.55 22 EDC - fresh 0.01 0.4 Calcium Carbonate 0.31 12.4 Isopropyl alcohol 0.04 fresh 1.6 TOTAL 1.47 58.8 5. 2,5- 40 2,5 Dihydroxy 0.44 Dihydroxybenzenesulfoni Benzene 17.6 c acid Diethylamine salt Sulphuric Acid 0.43 17.2 ANNEXURE-5
EDC - fresh 0.004 0.16 Diethyl amine 0.32 12.8 Acetone fresh 0.03 1.2 TOTAL 1.224 48.96 6. Valproic acid 40 Diethyl Malonate 1.11 44.4 . Butanol Fresh 0.7 28 Sodium Metal 0.15 6 N-Propyl Bromide 0.85 34 Hydrochloric acid 1.11 44.4 TOTAL 3.92 156.8 7. (2E)-[(4R)-4-(2,4- 40 2-chloro-1-(2,4 dichlorophenyl)-1,3- dichlorophenyl)ethan 0.63 dithiolan-2-ylidene]-(1H- ol 25.2 imidazole-1- Methylene dichloride 0.12 4.8 yl)ethanenitrile Methane sulphonyl 0.33 chloride 13.2 Triethyl amine 0.29 11.6 Isopropyl alcohol 0.03 1.2 1-Cyanomethyl 0.30 imidazole 12 Dimethyl sulfoxide 0.01 fresh 0.4 Caustic Potash 0.32 12.8 Carbon Disulphide 0.22 8.8 Ethyl acetate 0.01 0.4 Isopropyl alcohol 0.002 0.08 TOTAL 2.26 90.4 8. 3-[(2R,3R)-1- 40 (2S)-1- (dimethylamino)-2- (Dimethylamino)-2- 0.82 methylpentan-3-yl]phenol methylpentane-3-one 32.8 Bromo anisol 0.63 25.2 Magnesium turning 0.11 4.4 Tetrahydrofuran 0.03 Fresh 1.2 Acetic Acid 0.53 21.2 Toluene fresh 0.05 2 Methane Sulphonic Acid 0.82 32.8 Sulphuric Acid 0.35 14 NaOH 0.35 14 Ethyal acetate fresh 0.004 0.16 ANNEXURE-5
Pd/C 0.02 0.8 Methanol fresh 0.008 0.32 Dimethyal Sulfide 0.27 10.8 TOTAL 3.992 159.68 FOOD AND NEUTRACUTICAL PRODUCTS 9. L-2,5-Diaminopentanoic 40 L-2,5 acid-L-2- Diaminopentanoic 0.50 Aminobutanedioic acid acid 20 L-2 Aminobutanedioic 0.50 acid 20 Charcoal 0.0050 0.2 Methanol Fresh 0.03 1.2 TOTAL 1.035 41.4 10. L-γ-glutamyl-L-cysteinyl- 40 2- Amino -3 - glycine Sulfanylpropionic 0.89 acid 35.6 L-Glycine 0.25 10 Methanol Fresh 0.07 2.8 TOTAL 1.21 48.4 11. (2 R)-2-acetamido-3- 40 2- Amino -3 - 0.76 sulfanylpropanoic acid Sulfanylpropionic acid 30.4 L-Glycine 0.03 1.2 Methanol Fresh 0.32 12.8 TOTAL 1.11 44.4 12. Methyl sulphone 40 Dimethyl Sulphoxide 0.83 33.2 Hydrogen Peroxide 0.91 36.4 TOTAL 1.74 69.6 13. 2-Aminobutanedioic acid 40 L-2 0.88 Calcium salt Aminobutanedioic acid 35.2 Lime 0.25 10 TOTAL 1.13 45.2 14. Sodium iron (III) ethylene 40 Sodium hydroxide 0.1 4 diamine tetra acetate Ethylene diamine 0.7 tetra acetic acid 28 FeCl3 0.39 15.6 NaHCO3 0.60 24 TOTAL 1.79 71.6 ANNEXURE-5
15. Calcium salt of 2,6-dioxo- 40 NaoH 0.23 9.2 1,2,3,6-tetrahydro- Hydentoin 0.57 22.8 pyrimidine-4-carboxylic Glayaxolic acid 0.42 16.8 acid Hydrogen paroxide 0.19 7.6 Conc Hydrochloric 0.21 acid 8.4 Calcium oxide 0.16 6.4 TOTAL 1.78 71.2 COSMETIC PRODUCTS 16. 2- palmitoyloxymethyl-5- 40 2-hydroxymethyl- palmitoyloxy-y-pyrone 5hydroxy-y-pyrone 0.23 9.2 Pyridine 0.26 10.4 Palmitoyl Chloride 0.91 36.4 Toluene fresh 0.03 1.2 TOTAL 1.43 57.2 17. 6-palmitoyl-3-keto-L- 40 5-(1,2 gulofuranolactone dihydroxyethyl)-3,4 0.44 dihydroxyfuran 2-one 17.6 Dimethyl acetamide - 0.13 Fresh 5.2 Palmitoyl Chloride 0.69 27.6 TOTAL 1.26 50.4 18. 4-t-butyl-4’-methoxy- 40 Methyl-t-butyl 0.62 dibenzoyl methane benzoate 24.8 Methanol 0.12 4.8 4-Methoxy 0.64 acetophenone 25.6 Sodium methoxide 0.23 9.2 Hydrochloric acid 0.16 6.4 TOTAL 1.77 70.8 19. 2-(hydroxymethyl)-6-(4- 40 Glucose Pentaacetate 1.78 71.2 hydroxyphenoxy) Methylene dichloride 0.35 14 tetrahydro-2H-3,4,.5-triol 4-Hydroxy phenyl 0.7 acetate 28 Triethyl amine 0.46 18.4 NaoH 0.16 6.4 Acetic acid 0.25 10 Fresh Methanol 0.7 28 TOTAL 4.4 176 PHARMA AND DYES INTERMEDIATE PRODUCTS 20. Barbituric Acid 40 Diethyl Malonate 1.59 63.6 Methanol Fresh 1.00 40 Urea 0.59 23.6 ANNEXURE-5
Sodium Metal 0.22 8.8 Hydrochloric acid 1.59 63.6 TOTAL 4.99 199.6 21. Bis(2-chloroethyl)amine. 40 Diethyl Malonate 0.60 HCl 24 Ethylene Dichloride 0.18 fresh 7.2 Thionyl Chloride 1.59 63.6 TOTAL 2.37 94.8 22. 1-(4-Methoxy 40 Bis (2 Chloroethyl) phenyl)piperazine amine HCl 1.66 66.4 Tolune Fresh 0.17 6.8 Caustic Soda 1.11 44.4 P - Anisidene 1.00 40 TOTAL 3.94 157.6 23. N-Phenyl piperazine 40 Bis (2 Chloroethyl) 1.07 amine HCl 42.8 Toluene fresh 0.03 1.2 Caustic Soda LYE 1.14 50% 45.6 Aniline Oil 0.64 25.6 TOTAL 2.88 115.2 24. 2,3 40 Bis (2 Chloroethyl) 1.00 Dichlorophenylpiperazine amine HCl 40 Toluene Fresh 0.10 4 Caustic Soda Lye 1.60 50% 64 2, 3 Dichloro Aniline 1.50 60 TOTAL 4.2 168 25. 1,3-Chlorophenyl 40 Bis (2 Chloroethyl) 0.82 piperazine amine HCl 32.8 Toluene Fresh 0.05 2 Caustic Soda Lye 0.73 50% 29.2 m - Chloroaniline 0.57 22.8 TOTAL 2.17 86.8 26. Hydroxy ethyl piperazine 40 Piperazine Fresh 0.66 26.4 Ethylene Oxide 0.34 13.6 TOTAL 1 40 27. 1-H-1,2,4 triazole 40 Formic Acid 1.76 70.4 ANNEXURE-5
Ammonia 0.25 10 Hydrazine Hydrate 1.00 (50%) 40 TOTAL 3.01 120.4 28. Methyl-3-Amino 40 Methyl Acetoacetae 1.00 crotonate 40 Ammonia gas 0.18 7.2 TOTAL 1.18 47.2 29. Sodium-2-ethyl 40 2 Ethyl Hexanoic hexonoate Acid 0.90 36 Caustic Soda 0.20 8 TOTAL 1.10 44
ANNEXURE-6
MANUFACTURING PROCESS
1. BIS (DIETYLTHIOCARBAMOYL) DISULFIDE
CHEMICAL REACTION
CH CH3 S 3 H C NH CH 3 3 CS HCl S N + 2 + NaNO2 N S
S H3C Diethyl amine Carbon disulfide Sodium nitrite H3C C H N 4 11 76.14 68.99 Bis(diethylthiocarbomyl)disulfide 73.13 C10H20N2S4 296.53
PROCESS Diethyl amine, Carbon disulphide, Sodium hydroxide reacted with Sodium nitrite and adjusted pH with Hydrochloric acid to get Bis (diethylthiocarbonyl) disulphide, filter and washed with Water. It is dried and packed.
ANNEXURE-6
FLOW DIAGRAM WITH MATERIAL BALANCE
Input Kg Output Kg
Di-Ethyl Amine 100 Carbon Di- 104 Reaction Mass 759 sulphide Reaction Caustic Soda 55 DM Water 500 Total 759 Total 759
Reaction Mass 759 Reaction Mass 903
Sodium Nitrite 94 Reaction
Water 50 Total 903 Total 903
Reaction Mass 903Reaction Reaction Mass 1173 HCl 36% 270 Total 1173 Total 1173
Reaction Mass 1173 Wet Cake 239 Centrifuge and DM water 100 effluent 1034 Washing
Total 1273 Total 1273
Reaction Mass 239 Dry Product 190 Water to Drying 49 Evaporation
Total 239 Total 239
ANNEXURE-6
2. 1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE
CHEMCIAL REACTION
O O OH O OH OH O OH
H3C O O O CH3 H2O2 (CH3CO)2O OH O
O O O HO
1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone O HO 1,8-Dihydroxy-3-carboxyanthraquinone C15H10O5 1,8-Diacetoxy-3-carboxyanthraquinone 270.23 C15H8O6 C H O 284.22 19 12 8 368.29 PROCESS
1, 8-Dihydroxy 3- (hydroxymethyl) anthraquinone reacted with Potassium hydroxide and Hydrogen peroxide and adjusted pH with Conc. HCl to get 1, 8 dihydoxy- carboxyanthraquinone. This intermediate further reacted with Acetic anhydride and Sulphuric acid to get 1, 8-Diacetoxy-3-carboxyanthraquinone, it is filter, dried and pack.
ANNEXURE-6
FLOW DIAGRAM WITH MATERIAL BALANCE
STAGE-I
Input Kg Output Kg
1,8-Dihydroxy 3- (hydroxymethyl) 100 anthraquinone
Potassium Hydroxide 42Reaction Reaction Mass 492
Hydrogen Peroxide - 50 50% DM Water 300 Total 492 Total 492
Reaction Mass 492 Reaction Mass 601 HCl-36% 109 Crystallization
Total 601 Total 601
Wet Cake - 1, 8 Reaction Mass 601 116 Centrifuge & Dihyroxy 3- Water 50Washing Cb Waste Water h i 535
Total 651 Total 651
Reaction Mass 116 Dry Product 100 Drying Water to Evaporation 16
Total 116 Total 116
ANNEXURE-6
STAGE-II
Reaction Mass 100 Reaction Mass 237 Acetic Anyhdride 36 Reaction Acetic Acid recovered 80 Acetic Acid 4 Sulphuric Acid 17
Total 237 Total 237
Reaction Mass 237 Wet Cake 144 Water Recovered 80Centrifuge & Water + Acetic Acid 193 Fresh Water 20 Washing
Total 337 Total 337
Reaction Mass 144 Reaction Mass 444 DMAC Recovered 294 Purification DMAC fresh 6
Total 444 Total 444
Reaction Mass 444 Wet Cake 144 Centrifuge & Fresh water 100 DMAC 294 Washing Waste Water 106
Total 544 Total 544
Reaction Mass 144 Dry Product 129 Drying Water to Evaporation 15
Total 144 Total 144
MATERIAL BALANCE AT SOLVENT RECOVERY SYSTEM
Water Recovered 80 acetic acid + water 193Distillation Water 8 Coloumn Acetic Acid recovered 80 Residue 25 Total 193 Total 193
ANNEXURE-6
3. BIS[(R)-3-CARBOXY-2-HYDROXYPROPYL]TRIMETHYLAMMONIUM]L- TARTRATE
CHEMICAL REACTION
CH3 OH O + CH3 OH O OH O N - OH O + H3C O N - HO CH H C O 3 HO 3 + OH CH OH O CH3 3 OH O OH + N - O OH H C O (R)-3-carboxy-2-hydroxypropyl- 3 L-Tartaric acid CH3 -trimethyl ammonium C4H6O6 Bis{(R)-3-carboxy-2-hydroxypropyl- C H NO 7 15 3 150.08 -trimethyl ammonium} -L-Tartrate 161.19 C18H36N2O12 472.49 PROCESS [R]-3 - Carboxy -2 - hydroxypropyl-trimethylammonium reacted with L-Tartaric Acid to get Bis [R]-3 - Carboxy -2 - hydroxypropyl-trimethyl ammonium L – Tartarate, which is filter, dried and pack. MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
3-carboxy-2- 100 hydroxypropyl-trimethyl MeoH recovered 250Reaction Reaction Mass 397 L-Tartaric acid 47
Total 397 Total 397
Reaction Mass 397Centrifuging and wet cake 154 MeoH fresh 6Washing MeoH 287 MeoH recovered 44 Send to ETP 6 Total 447 Total 447
Reaction Mass 154 Dry Product 147 Vacuum Drying MeoH 7 Total 154 Total 154
ANNEXURE-6
4. 2,5-DIHYDROXYBENZENESULFONIC ACID CALCIUM SALT CHEMICAL REACTION
OH OH OH
+ + H2SO 4 CaCO 3 Ca O + O - - O O S S OH OH O O OH 2,5 Dihydroxy benzene Sulphuric acid Calcium Bis(2,5-Dihydroxy benzenesulhonicacid) calcium salt C6H6O2 98.07 Carbonate 110.11 100.08 C12H10O10S2Ca 418.40 PROCESS
2, 5 Dihydroxy Benzene reacted with Sulphuric acid and Calcium carbonate to get 2, 5- Dihydroxybenzenesulfonic acid calcium salt which is clatify and crystalise, dried and packed.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
2,5 Dihydroxy 100 Benzene Sulphuric Acid 98Reaction Reaction Mass 298 EDC -recovered 99 EDC - fresh 1 Total 298 Total 298
Reaction Mass 298 Layer Separation Reaction Mass 299 Reused water 100 EDC 99 Total 398 Total 398
Reaction Mass 299 Reaction Mass 430 Reaction Calcium Carbonate55 CO2 24 Reused water 100 Total 454 Total 454
Reaction Mass Reaction Mass 430 508 solution fresh water 60 Clarifiying and Washing Reused water 40 Calcium Sulphate22
Total 530 Total 530
Reaction Mass 508 Evaporation Loss 15 solution Distilllation Distilled water 240 Reaction Mass 253 Solution Total 508 Total 508
ANNEXURE-6
Reaction Mass 253Crystallization Reaction Mass 453 Solution IPA - recovered 200
Total 453 Total 453
Wet Cake 196 Reaction Mass 453 IPA + Water 357 Centrifuging and Washing IPA - recovered 93 IPA - fresh 7
Total 553 Total 553
Reaction Mass 196 Dry Product 179 Vacuum Drying IPA+WATER 18
Total 196 Total 196
IPA + Water 374 water to ETP 81 Distillation IPA Recovered 293
Total 374 Total 374
ANNEXURE-6
5. 2, 5-DIHYDROXYBENZENESULFONIC ACID DIETHYLAMINE SALT
PROCESS
2, 5 Dihydroxy Benzene reacted with Sulphuric acid and Calcium carbonate to get 2, 5- Dihydroxybenzenesulfonic acid calcium salt which is clatify and crystalise, dried and packed.
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
2,5 Dihydroxy Benzene 100 Sulphuric Acid 98 Reaction Mass 298 Reaction EDC -recovered 99 EDC - fresh 1 Total 298 Total 298
Reaction Mass 298 Reaction Mass 299 Recovered water 80Layer Separation EDC 99 Water 20 Total 398 Total 398
Reaction Mass 299Reaction Reaction Mass 372 Diethylamine 73
Total 372 Total 372
Reaction Mass solution 372 Reaction mass 288 Distillation Distillate water 80 Evaporation loss 4 Total 372 Total 372
Reaction mass 672 Reaction Mass Solution 288Clarification DEA Sulfate 16 Acetone recovered 400
Total 688 Total 688
Reaction Mass 672 Reaction mass 464 Distillation & For acetone recovery 200 Crystallization Evaporation loss 8
Total 672 Total 672
Wet Cake 250 Reaction Mass 464Centrifuging and Acetone + water + Product 314 Acetone recover 93 Washing Acetone fresh 7
Total 564 Total 564
ANNEXURE-6
Wet cake 250 Dry Product 227 Vacuum Drying For acetone recovery 23
Total 250 Total 250
MATERIAL BALANCE AT SOLVENT RECOVERY SYSTEM
Aceone containg effluent 537 Distillation Coloumn Acetone recover 493 Residue 44 Total 537 Total 537
6. VALPROIC ACID
CHEMICAL REACTION
O OO CH3 Na Metal HO Br H3C OOCH3 + H3C NaOH
CH3 Diethyl malonate n-propyl bromide Valproic acid C7H12O4 C H Br 3 7 C8H16O2 160.16 122.99 144.21 PROCESS Metal dissolved in alcohol than heat. Add D.E.M., P.B. to reaction temperature. After distilled out alcohol add water and separate crude product and mother liquor. Hydrolyze by adding sodium hydroxide and crude after distillation of alcohol and acidification by hydrochloric acid. After di carboxylation and distillation pure products will be obtained.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Diethyl Malonate 100 Butanol recovered 375 Butanol Fresh 63Reaction Reaction Mass 629 Sodium Metal 14 N-Propyl Bromide 77 Total 629 Total 629
Reaction Mass 629 Reaction Mass 192 Butanol Recovered 375 Distillation Evaporation Loss 62
Total 629 Total 629
Reaction Mass 192Acidification Reaction Mass 292 HCl 100 Total 292 Total 292
Reaction Mass 292 Waste Water 180 Filteration Reaction Mass 112 Total 292 Total 292
Dry Product 90 Reaction Mass 112 Drying Losses 22 Drying
Total 112 Total 112
ANNEXURE-6
7. (2E)-[(4R)-4-(2,4-DICHLOROPHENYL)-1,3-DITHIOLAN-2-YLIDENE]- (1H-IMIDAZOLE-1-YL)ETHANENITRILE
CHEMICAL REACTION
Cl Cl Cl Cl OH OSO CH NN 2 3 + CN
Cl Cl
2-Chloro-1-(2,4 Dichloro- [1-(2,4 Dichloro phenyl)-2-chloro- 1-Cyanomethyl imidazole
-phenyl)ethanol -ethyl]-methane sulphonate C5H5N3 C8H7Cl3O C9H9Cl3O3S 107.11 225.49 303.58
Cl Cl
CN S
S N
N (2E)-[(4R)-4-(2,4-dichlorophenyl)- -1,3-dithiolan-2-ylidene]- -(1H-imidazol-1-yl)ethanenitrile (Luliconazole) C14H9Cl2N3S2 354.27
PROCESS
Methane sulphonation of 2-Chloro-1(2,4Dichlorophenyl)ethanol with Methane sulphonyl chloride in presence of Triethyl amine to get [1-(2,4 Dichloro phenyl)-2-chloro ethyl] methane sulphonate, which filter out and dried. This intermediate reacts with 1- Cyanomethyl imidazole in presence of Potassium hydroxide and Carbon disulphide to get (2E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-(1H-imidazole-1- yl)ethanenitrile (Luliconazole), which filter out, dry and pack. ANNEXURE-6
FLOW DIAGRAM AND MATERIAL BALANCE
STAGE-1
Input Kgs Out Put Kg 2‐chloro‐1‐(2,4 dichlorophenyl)ethanol 100 MDC 500.0 Reaction Methane sulphonyl chloride 50.8 Reaction Mass 695.70 Triethyl amine 44.9 Total 695.70 695.70
Reaction Mass 695.70 Reaction Mass 634.60 Layer Water 100 Waste Water to ETP 161.1 Seperation
Total 795.70 Total 795.7
Reaction Mass 634.6 Reaction Mass 134.6 MDC Recover MDC 480 Distilation MDC Evaporation 20 Total 634.6 634.6
Reaction Mass 134.6 Reaction Mass 434.6 Isopropyl alcohol Recovered 300 Crystallization
Total 434.6 434.6
Reaction Mass 434.6 Product W/c 149.6 Centrifuge and Isopropyl alcohol recovered 95 Isopropyl alcohol for recovery 385 washing Isopropyl alcohol fresh 5 Total 534.6 534.60
Product W/c 149.6 Dry Product 134.6 Vacuum Isopropyl alcohol Recover 10 Drying Loss 5 Total 149.6 149.6
ANNEXURE-6
STAGE-2
[1‐(2, 4‐dichlorophenyl)‐2‐ chloroethyl] methane sulphonate 134.6 Reaction Mass 300.23 1‐Cyanomethyl imidazole 47.5 Reaction DMSO recovered 32.8 DMSO fresh 1.8 Caustic Pootash 49.8 Carbon Disulphide 33.8 Total 300.23 300.23
Reaction Mass 300.23 Reaction Mass 230.80 Layer Effluent 116.6 Water 8.1 Seperation Ethyl acetate fresh 37.5 Ethyl acetate recovered 1.6 Total 347.4 347.4
Reaction Mass 230.80 Reaction Mass 157.1 Ethyal Acetat Reover 37.5 Distilation Ethyal Acetat Evoparation 3.4 DMSO Distilled 32.8 Total 230.8 230.80
Reaction Mass 157.1 Reaction Mass 183.70 Isopropyl alcohol fresh 0.4 Crystallization Isopropyl alcohol recovered 26.2 Total 183.70 183.70
Reaction Mass 183.70Centrifuge and Product W/c 158.70 washing Isopropyl alcohol 25
183.70 183.70
Product W/c 158.70 Dry Product 157.10 Vacuum Isopropyl alcohol Recover 1.20 Drying Loss 0.4 Total 158.70 158.70
ANNEXURE-6
8. 3-[(2R,3R)-1-(DIMETHYLAMINO)-2-METHYLPENTAN-3- YL]PHENOL
CHEMICAL REACTION OCH OCH3 3 O
+ H3C CH3 N OH Br H3C CH3 CH3 CH3 N
CH3 CH3 3-Bromo anisol (2S)-1-(dimethylamino)-2-
C7H7BrO -methylpentan-3-one (2S,3R)-1-(dimethylamino)- 3-(3-methoxyphenyl)-2 187.03 C8H17NO 143.22 -methylpentan-3-ol C15H25NO2 251.36
OCH3 OCH OH 3
OSO CH H C CH 2 3 3 3 H3C CH3 H3C CH3 N N N CH CH 3 3 CH3 CH3 CH3 CH3
(2S,3R)-1-(dimethylamino)-3- 3-[(2R,3R)-1-(dimethylamino)- (2R,3R)-3-(3-methoxyphenyl)- -2-methylpentan-3-yl]phenol -N,N,2-trimethylpentan-1-amine -(3-methoxyphenyl)-2-methylpentan- -3-yl-methanesulfonate (Tapentadol) C15H25NO C16H27NO4S C14H23NO 235.36 329.45 221.33
ANNEXURE-6
PROCESS
In first step Grignard reaction of 3-Bromo anisol with (2S)-1-(dimethylamino)-2- methylpentan-3-one by using magnesium turning to get 3-(3-methoxyphenyl)2- methylpentan-3-ol, which filter out and dried. This intermediate react with Methane sulphonic acid in presence of Sulphuric acid and pH adjusted by Sodium hydroxide to get (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-yl- methanesulphonate, which filter out and dried and use for next step. In third step using Pd/C and to get (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentan-1-amine, which filter out and dried. In last step (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentan-1- amine react with Methane sulphonic acid and Dimethyl sulfide to get 3-[(2R,3R)-1- (dimethylamino)-2-methylpentan-3-yl]phenol (Tepentadol), which filter out, dry and pack
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
STAGE-1
Input Kgs Out Put Kg (2S)‐1‐(Dimethylamino)‐2‐ methylpentane‐3‐one 100 Bromo anisol 76.6 Reaction Mass 228.20 Magnesium turning 13.0 Reaction Tetrahydrofuran recycled 34.9 Tetrahydrofuran Fresh 3.7 Total 228.20 228.20
Reaction Mass 228.20 Acetic Acid 64.2 Quenching and Mass 302.00 Water 9.6 pH adjustment
Total 302.00 302.00
Reaction Mass 302.00 Tetrahydrofuran recycled 38.60 Reaction Mass 211.60
Layer separation Waste Water to ETP 129
Total 340.600 340.600
Reaction Mass 211.60 Reaction Mass 134.50 THF Recover 73.50 Distilation THF Evoparation 3.60
Total 211.60 211.60
Reaction Mass 134.50 Product W/c 136.80 Toluene Recycled 48.5 Centrifuge and Tolune 47.0 Toluene fresh 0.8 washing Total 183.80 183.80
Product W/c 136.80 Dry Produt 134.60 Toluene 1.5 Vacuum Drying Toluene loss 0.8
Total 136.80 136.90
ANNEXURE-6
STAGE-2
(2S,3R)‐1‐(Dimethylamino)‐ 3‐(3‐methoxyphenyl)‐2‐ methylpentane‐3‐one 134.50 Reaction Mass 267.26 Methane Sulphonic Aid 51.4 Reaction Sulphuric Aid 42.8 Tetrahydrofuran fresh 3.6 Tetrahydrofuran recovered 35.0 267.26 267.26
Reation Mass 267.26 NaOH 42.8 Quenching and Reaction Mass 319.66 Water 9.6 pH adjustment Total 319.66 319.66
Reaction Mass 319.66 Reaction Mass 214.76
Layer separation Wast Water to ETP 104.9
Total 319.66 319.66
Reaction Mass 214.76 Reaction Mass 176.16 THF Recover 35.00 Distilation THF Evoparation 3.60
Total 214.76 214.76
Reaction Mass 176.16 Product W/C 178.26 Ethyal Aetate recovered 46.5 Ethyal Aetate Recover 45.0 Centrifuge and Ethyal acetate fresh 0.6 washing Total 223.26 Total 223.26
Product W/c 178.26 Product W/C 176.16 Ethyal Aetate Reover 1.5 Vacuume Drying Ethyal acetate loss 0.6
Total 178.26 Total 178.26
ANNEXURE-6
STAGE-3
(2S,3R)‐1‐(Dimethylamino)‐ 3‐(3‐methoxyphenyl)‐2‐ methylpentane‐3‐yl‐4‐ methylsulphonate 176.16 Reaction Mass 266.16 Reaction Pd/C 2.60 Pd/C 48.8 Tetrahydrofuran Fresh 3.6 Tetrahydrofuran Recovered 35.0 266.16 266.16
Reaction Mass 217.36 Reaction Mass 266.16 Centrifuge and Pd/C Recover 48.8 washing 266.16 266.16
Reaction Mass 176.16 Reaction Mass 217.36 THF Recover 35.00 Distilation Loss 6.20 217.36 217.36
Reaction Mass 176.16 Reaction Mass 174.66 Water 9.6 Waste Water to ETP 60.4 Toluene fresh 3.3 Layer separation Toluene recovered 46.0 Total 235.06 235.06
Reaction Mass 125.36 Reaction Mass 174.66 Tolune 46.00 Distilation Tolune Evoparation 3.30 174.66 174.66
Produt W/c 127.46 Reaction Mass 125.36 IPA 30.0 Centrifuge and IPA recovered 31.30 washing IPA fresh 0.80 157.46 157.46
Produt W/c 127.46 Dry Product 125.36 IPA Recover 1.3 Vacuume Drying IPA loss 0.8 127.46 Total 127.46
ANNEXURE-6
STAGE-4
(2R,3R)‐3‐3‐(3‐ methoxyphenyl)‐N,N‐2‐ trimethylpentane‐1‐amine Reaction Mass 209.36 125.36 Reaction Methane sulphonic acid 50.8 Dimethyal Sulfide 33.2 209.36 209.36
Reation Mass 209.36 Water 9.6 Reaction Mass 218.96 Quenching Total 218.96 218.96
Reaction Mass 218.96 Reaction Mass 167.46 Toluene Fresh 3.3 Toluene recovered 46.0 Layer separation
waste water to ETP 100.8 Total 268.26 268.26
Reaction Mass 118.16 Reaction Mass 167.46 Tolune 46.00 Distilation Tolune Evoparation 3.30 167.46 167.46
Produt W/c 120.5 Reaction Mass 118.16 Methanol 32.0 Centrifuge and Methanol fresh 33.30 washing Methanol recycled 1.00 152.46 152.46
Produt W/c 120.5 Dry Product 121.46 Methanol Recover 1.3 Vacuum Drying Methanol loss 1.0 120.46 Total 123.76
ANNEXURE-6
9 L-2, 5-DIAMINOPENTANOIC ACID-L-2-AMINOBUTANEDIOIC ACID
CHEMICAL REACTION
OH OH OH OH OH O NH2 + O OH O NH2. O NH NH O 2 2 NH 2 NH2 O
L-2,5-Diaminopentanoicacid L-2-Aminobutanedioicacid L-2,5-Diaminopentanoicacid-L-2-Aminobutanedioicacid C H N O 5 12 2 2 C4H7NO4 C9H19N3O6 132.16 133.10 265.26 PROCESS
L-2,5-Diaminopentanoic acid and L-2-Aminobutanedioic acid mix in Water then treat with charcoal and crystalise in Methanol to get L-2,5-Diaminopentanoic acid-L-2-Aminobutanedioic acid, filter, dried in Vacuum drier and pack.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
L-2,5 100 Diaminopentanoic acid DM -Water 100Reaction Reaction Mass 301 L-2 Aminobutanedioic 101 acid Total 301 Total 301
Reaction Mass 301 Reaction Mass 320 DM-Water 20Charcoal loss in air 1 Treatment & Charcoal 1 Charcoal 1 Filteration
Total 322 Total 322
Reaction Mass - Reaction Mass 320 216 Prepipation and wet Cake Methanol recovered 194 Filteration Methanol Fresh 6 Water +Methanol 304
Total 520 Total 520
Reaction Mass 216 Dry Product 201 Vacuum Drying Water + 15 Methanol Total 216 Total 216
Recovered Pure 194 Methanol Water +Methanol 319Distillation Water 125
Total 319 Total 319
ANNEXURE-6
10 L-GLUTAMYL-L-CYSTEINYL-GLYCINE
CHEMICAL REACTION
OH OH OH OH SH O O O NH2 OO+ O SH + O NH HNHO OH NH NH2 2 NH2 O 2-Aminoglutaricacid Cysteine Glycine C H NO C H NO L-y-glutamyl-L-cysteinyl-glycine 5 9 4 C3H7NO2S 2 5 2 147.12 C H N O S 121.15 75.06 10 17 3 6 307.32 PROCESS
2-Aminoglutaric acid is reacted with GlycineThe solids formed are filtered, and vacuum dried to get product to pack.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
2- Amino -3 - 182 Sulfanylpropionic acid Reaction Reaction Mass 282 Methanol Recovered 100
Total 282 Total 282
Reaction Mass 282 Reaction Mass 333 L-Glycine 51 Reaction
Total 333 Total 333
Reaction Mass 333Prepipation and Reaction Mass - wet Cake 248 Methanol Recovered 185 Filteration Methanol Fresh 15 Water +Methanol 285 Total 533 Total 533
Reaction Mass 248 Dry Product 205 Vacuum Drying Water + Methanol 43 Total 248 Total 248
MATERIAL BALANCE AT SOLVENT RECOVERY SYSTEM
Water + Methanol 328 Recovered Methanol 285 Distilation waste water 43 Total 328 Total 328
ANNEXURE-6
11. (2R)-2-ACETAMIDO-3-SULFANYLPROPANOIC ACID
CHEMICAL REACTION
OH OH
O SH + H3C OCH3 O SH NH O NH 2 O O
CH 2-Amino-3-sulfanylpropionic acid Acetic anhydride 3 (2R)-2-acetamido-3-sulfanylpropionic acid C3H7NO2S C4H6O3 121.15 102.08 C5H9NO3S 163.19 PROCESS
Acetylization of 2- Amino -3 - Sulfanylpropionic acid is carried out in presence of acetic acid. The solids formed are filtered, washed and vacuum dried to get product to pack.
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
2- Amino -3 - 100 Sulfanylpropionic acid Acetic acid recovered 70Reaction Reaction Mass 216 Acetic Acid 4 Acetic Anhydride 42 Total 216 Total 216
Reaction Mass 216 Reaction Mass 141 Water recovered 50 Acetic Acid + Water 125 Centrifusing and Washing
Total 266 Total 266
Reaction Mass 141Vacuum Drying Dry Powder 132 Water + Acetic acid 9 Total 141 Total 141
Water Recovered 50 acetic acid + water 134 Water 13 Distillation Coloumn Acetic Acid recovered 70 Residue 1 Total 134 Total 134 ANNEXURE-6
12. METHYL SULPHONE
CHEMICAL REACTION
H 3 C CH3 O S H 3 C CH3 + H 2 O 2 S O O Dimethyl sulfoxide Hydrogen peroxide Methyl sulphone C 2 H 6 OS 34.01 C 2 H 6 O 2 S 78.13 94.13 PROCESS
Dimethyl Sulphoxide is oxidized with hydrogen peroxide. The product is crystallized, filtered, washed and vacuum dried to pack.
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Dimethyl Sulphoxide 100 Reaction Reaction Mass 209
Hydrogen Peroxide 109 Total 209 Total 209
Reaction Mass 209 Reaction Mass 209
Crystallization
Total 209 Total 209
Reaction Mass - wet Reaction Mass 209 Centrifuging and 126 Washing Cake Water 200 Waste Water +H202 283 Total 409 Total 409
Reaction Mass 126 Dry Product 120 Vacuum Drying Water 6 Total 126 Total 126
ANNEXURE-6
13.2-AMINOBUTANEDIOIC ACID CALCIUM SALT
CHEMCIAL REACTION
OH - O OH - O O O ++ + Ca(OH) 2 Ca NH2 O NH2 O
L-2-Aminobutanedioicacid Calcium hydroxide L-2-Aminobutanedioicacid calcium salt
C 4H 7NO 4 74.0 C 4H 6NO 4Ca 133.10 171.16
PROCESS
L-2 Aminobutanedioic acid reacted with Lime in Water to get L-2-Aminobutanedioic acid calcium salt, it is filrer, sraydring and pack.
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
L-2 Aminobutanedioic acid 100 Reaction Lime 28 Reaction Mass 228 DM Water 100
Total 228 Total 228
Reaction Mass 228 Dry Product 114 Water -Evaporation 114 Filtration & Spray ( unit has no spray drier Drying so spray drying will be done by outside. Total 228 Total 228
ANNEXURE-6
14-SODIUM IRON (III) ETHYLENE DIAMINE TETRA ACETATE
CHEMICAL REACTION
COOH - COO COOH - NaOH COO NCH2 H2CN + 3+ NCH H CN Na Fe HOOC 2 2 FeCl3 - O OC HOOC .3H2O - O OC
Ethylenediamine tetraaceticacid Sodium iron (III) ethylene diamine tetra acetate
C10H16N2O8 (Sodium Feredetate) 294.24 C10H12FeN2NaO8.3H2O 421.09
PROCESS
This is Chelate formation reaction, EDTA reacted with Sodium hydroxide to get Sodium salt of EDTA, this salt react with Ferric chloride and adjusted of pH with Sodium bicarbonate to get the Sodium iron (III) ethylene diamine tetra acetate (Sodium Feredetate), which filter out and dried.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kgs Out Put Kg
Water 98 NaOH 13.6Reaction Reaction Mass 211.6 EDTA 100 Total 211.6 211.6
Reaction Mass 211.6 Reaction Mass 266.7 Ferric chloride solution Reaction (41 to 43%) 55.1 266.7 TOTAL 266.7
Reaction Mass 266.7 Product in W/c 149.8 Sodium bicarbonate 85.7 Centrifuging Waste water 157.6 Carbon dioxide 45 Total 352.4 352.4
Product in W/c 149.8 Drying Product 143.1 Water Evoporation 6.7 Total 149.8 149.8
ANNEXURE-6
15. CALCIUM SALT OF 2,6-DIOXO-1,2,3,6,-TETRAHYDRO-PYRIMIDINE-4- CARBOXYLIC ACID
PROCESS REACTION
O - O OC O HOOC O HOOC CHO + HN NH NaOH CaO HN NH +2 HN NH Ca O O O 2 Gyoxalic acid Hydentoin 2,6-dioxo-1,2,3,6-tetrahydro- C2H2O3 C3H4N2O2 -pyrimidine-4-carboxylic acid Calcium salt of 74.03 100.07 (Orotic acid) 2,6-dioxo-1,2,3,6-tetrahydro C5H5N2O4 -pyrimidine-4-carboxylic acid 156.09 (Calcium salt of oroticacid)
C10H6N4O8Ca 350.25 PROCESS DESCRIPTION
Glyoxalic acid reacts with Hydentoin in presence of Sodium hydroxide to get 2,6-dioxo- 1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid (Orotic acid) and it is react with Calcium oxide to get Calcium salt of 2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid (Calcium salt of Orotic acid), which filter out and dried.
ANNEXURE-6
MATERIAL BALANCE AND FLOW DIAGRAM
Input Kg Output Kg
Water 1000 Reaction Mass1214 NaoH 40 Hydentoin 100 REACTION Glayaxolic acid 74
Total 1214 Total 1214
Reaction Mass 1214 Neutralized mass 1284.4 Hydrogen paroxide 34 REACTION & pH Conc Hydrochloric acid 36.4 ADJUSTMENT
Total 1284.4 Total 1284.4
Neutralized mass 1284.4FILTERATION Orotic acid wet cake 229 Water for washing 200 Waste water to ETP 1255.4 Total 1484.4AND WASHING Total 1484.4
Wet Cake 229 Water 200GLASS LINE Neutralized mass 457 Calcium oxide 28 REACTOR pH ADJUSTMENT TOTAL 457 TOTAL 457
Reaction Mass 457CENTRIFUGE AND Wet Cake 271 Water 250 Waste water to ETP 436 Total 707WASHING Total 707
Reaction Mass 271 Dry Product 175 DRYING Drying Loss 96
Total 271 Total 271
ANNEXURE-6
16. 2-PALMITOYLOXYMETHYL-5-PALMITOYLOXY-Y-PYRONE
CHEMICAL REACTION
O O OH O CH2OCO(CH2)14CH3 + H C(H C) H C Cl HO 3 2 13 2 H C(H C) OCO O 3 2 14 O 5-Hydroxy-2-(hydroxy- Palmitoyl chloride 2- palmitoyloxymethyl-5-pamitoyloxy-y-pyrone -methyl)-4H-pyran-4-one C16H31ClO C38H66O6 C6H6O4 274.86 142.10 618.92 PROCESS
2-hydroxymethyl-5hydroxy-y-pyrone reacted with Palmitoyl Chloride and Pyridine to get the 2- palmitoyloxymethyl-5-palmitoyloxy-y-pyrone, which filter out and washed. It is dried and packed
MATERIAL BALANCE AND FLOW DIAGRAM
Input Kg Output Kg
2-hydroxymethyl- 100 5hydroxy-y-pyrone Toluene -recovered 454Reaction Reaction Mass 1052 Pyridine 111 Palmitoyl Chloride 387 Total 1052 Total 1052
Reaction Mass 1052 Reaction Mass 470 Toluene Fresh 11 Filtration and Toluene Recovered 74 Toluene 528 Washing Water + Pyridine Water 400 539 Chloride Total 1537 Total 1537
Reaction Mass 470Drying Dry Product 427 Water-Drying Loss 43 Total 470 Total 470
ANNEXURE-6
17. 6-PALMITOYL-3-KETO-L-GULOFURANOLACTONE
CHEMICAL REACTION
OH OH O O O O O OH O CH2(CH2)13CH3 + H3C(H2C)13H2C Cl HO OH HO OH O
5-(1,2-dihydroxyethyl)- Palmitoyl chloride 6-palmitoyl-3-keto-L-gulofuranolactone -3,4-dihydroxyfuran-2-one C16H31ClO C22H38O7 C6H8O6 274.86 176.12 414.53 PROCESS DESCRIPTION
5-(1,2dihydroxyethyl)-3,4 dihydroxyfuran 2-one reacted with Palmitoyl Chloride to get the 2- Palmitoyloxymethyl 5-Palmitoyloxy-y-pyrone which is filter and dried.
MATERIAL BALANCE AND FLOW DIAGRAM
Input Kg Output Kg
5-(1,2 dihydroxyethyl)-3,4 dihydroxyfuran 2-one 100 DMAC -recovered 270Reaction Reaction Mass 556 DMAC -Fresh 30 Palmitoyl Chloride 156 Total 556 Total 556
Reaction Mass 556 Reaction Mass 1056 Water 500 Crystallization
Total 1056 Total 1056
Reaction Mass 1056 Wet Cake 267 Centrifusing and Water 100 DMAC -recovery, r 270 Washing Evaporation Loss 30 Dilute HCl 589 Total 1156 Total 1156
Wet Cake 267 Dry Powder 226 Drying Drying Loss 41
Total 267 Total 267
ANNEXURE-6
18. 4-T-BUTYL-4-METHOXY-DIBENZOYL METHANE
CHEMICAL REACTION
COOMe OCH3 O O
+ NaOMe H3C OCH3 CH3 CH COCH 3 3 CH3 H3C CH3
Methyl-t-butyl benzoate 4-Methoxy acetophenone 4-t-butyl-4'-methoxy-dibenzoyl methane
C12H16O2 C9H10O2 (Avobenzon) 192.25 150.17 C20H22O3 310.38
PROCESS
Methyl-t-butyl benzoate reacts with 4-Methoxy acetophenone in presence of Sodium methoxide and adjustment of by Conc.Hydrochloric acid to get 4-t-butyl-4’-methoxy-dibenzoyl methane (Avobenzon), which filter out and dried.
ANNEXURE-6
MATERIAL BALANCE AND FLOW DIAGRAM
Input Kgs Out Put Kg Methyl‐t‐butyl benzoate 100 Methanol recovered 485.0 4‐Methoxy acetophenone 78.1 Reaction Mass 715.60 Reaction Sodium methoxide 28.1 Fresh methanol 15.0 Water 9.4 Total 715.60 715.60
Reaction Mass 715.60 Reaction Mass 734.60 HCL 19 pH Adjustment Total 734.60 734.60
Reaction Mass 734.60Centrifuge and Product W/c 166.91 washing Methanol for Recovery 485 Water 125 Waste water to ETP 207.69
Total 859.60 859.6
Produt W/c 166.91 Dry Product 161.4 Drying Water Evaporation 5.51 Total 166.91 166.91
ANNEXURE-6
19. 2-(HYDROXYMETHYL)-6-(4-HYDROCYPHENOXY)TETRAHYDRO-2H- 3,4,5,TRIOL
CHEMICAL REACTION
OCOCH3 OCOCH3 OCOCH3
CH3COO CH3COO + O O
CH3COO OCOCH3 CH3COO O OH OCOCH3 OCOCH3 OCOCH3
4-hydroxyphenyl acetate Glucose pentaacetate Penta-O-acetyl arbutin C H O C8H8O3 16 22 11 C22H26O12 390.33 152.14 482.43
OH
HO O
HO O OH OH
2-(hydroxymethyl)-6-(4-hydroxyphenoxy)- -tetrahydro-2H-pyran-3,4,5-triol (Arbutin)
C12H16O7 272.25
PROCESS DESCRIPTION
4-Hydroxyphenyl acetate react with Glucose pentaacetate in presence of Triethyla mine and Borontrifluoride to get Penta-O-acetalarbutin, which filter out and dried. Hydrolysis of Penta-O-acetalarbutin with Sodium hydroxide to get 2-(hydroxymethyl)-6-(4- hydroxyphenoxy)tetrahydro-2H-3,4,5-triol (Arbutin), which filter out and dried.
ANNEXURE-6
MATERIAL BALANCE AND FLOW DIAGRAM
Input Kgs Out Put Kg Glucose Pentaacetate 100 MDC fresh 20.0 4‐Hydroxy phenyl acetate 39.0 Reaction Mass 664.9 Reaction Triethyl amine 25.9
MDC recovered 480 Total 664.9 664.9
Reaction Mass 664.9 Reaction mass 615.30 Water 200 effluent 249.60 Layer Seperation
Total 864.9 Total 864.90
Reaction Mass 615.30 Reaction Mass 115.30 MDC Recover MDC 480 Distillation MDC Evaporation 20 Total 615.30 615.30
Reaction Mass 115.30 Reaction Mass 415.30 Crystallization Recovered Methanol 300 Total 415.30 415.30
Reaction Mass 415.30 Product W/c 131.30 Centrifuge and Fresh methanol 6.00 washing Recovered Methanol 44 Recover Methanol 334.0 Total 465.30 465.30
Product W/c 131.30 Dry Product 115.3 Vacuum Loss methanol 6 Drying Recover methanol 10 Total 131.30 131.30
ANNEXURE-6
Penta‐O acetyal Arbutine 115.3 Reaction Mass 646.3 Methanol 500.0 Sodium Hydroxide 9.5 Reaction Water 21.5
Total 646.3 646.3
Reaction Mass 646.3 Reaction Mass 660.6 Acetic acid 14.3 pH Adjustment
Total 660.6 660.6
Reaction Mass 660.6 Product W/c 84 Recovered Methanol 76Centrifuge and Methanol recovery 560 Fresh methanol 24washing Acetic acid 77 Effluent 39.6 Total 760.6 760.6
Product W/c 84 Dry Product 56 Vacuum Methanol Recover 16 Drying Loss 12 Total 84 84
20.BARBITURIC ACID
CHEMICAL REACTION
O OO O Na Metal HN NH H3C OOCH3 + H2N NH2 HCl O O Diethyl malonate Urea Barbituric acid C7H12O4 CH4N2O 160.16 C4H4N2O3 60.05 128.08 PROCESS
Di ethyl melonate reacted with urea in methoxide solution then it is acidify to get barbituric acid which is filter, dried & packed.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Diethyl Malonate 100 Methanol 375 RdMethanol Fresh 63Reaction Reaction Mass 589 Urea 37 Sodium Metal 14 Total 589 Total 589
Reaction Mass 589 Reaction Mass 152 Recovered Methanol 375 Distillation Evaporation Loss 62
Total 589 Total 589
Reaction Mass 152Acidification Reaction Mass 252 HCl 100 Total 252 Total 252
Reaction Mass 252 Waste Water 180 Filtrate Reaction Mass 72 Total 252 Total 252
Dry Product 63 Reaction Mass 72 Drying Losses 9 Drying
Total 72 Total 72
ANNEXURE-6
21. BIS(2-CHLOROETHYL)AMINE-HCl
PROCESS REACTION
HO OH SOCl Cl Cl NH + 2 NH
Diethanol amine Thionyl chloride Bis(2-chloroethyl) amine .HCl C H NO 4 11 2 118.97 C H Cl N.HCl 105.13 4 9 2 178.49 PROCESS
Diethanol Amine reacted with thionyl chloride in solvent to get Bis - 2 - Chloro Ethyl Amine Hydrochloride semi solid material which filter out. It is dried & packed.
PROCESS FLOW DIAGRAM AND MATERIAL BALANCE
Input Kg Output Kg
Diethyl Malonate 100 HCl gas 36.5 Ethylene Dichloride recovered 703Reaction Reaction Mass 1062.5 Ethylene Dichloride fresh 30 Thionyl Chloride 266 Total 1099 Total 1099
Reaction Mass 1062.5 Reaction Mass 396 EDC recovery and reuse 640 Distillation Evaporation Loss 26.5
Total 1062.5 Total 1062.5
Reaction Mass 396Centrifuge Wet Cake 333 EDC to resue 63 Total 396 Total 396
Dry Powder 167 Wet Cake 333 Drying Losses 166 Drying
Total 333 Total 333
ANNEXURE-6
22. 1-(4-METHOXY PHENYL) PIPERAZINE
PROCESS REACTION
OCH3
Cl Cl NaOH N NH NH + H3CO
Bis(2-chloroethyl) amine .HCl NH2 C4H9Cl2N.HCl p-Anisidine 1-(4-Mehoxy phenyl)piperazine 178.49 C7H9NO C11H16N2O 123.15 192.26 PROCESS
Para Anisidine reacted with Bis 2 - Chloro Ethyl Amine Hydrochloride salts to get 1 - (4 - wlethoxy Phenyl ) Piperazine, then it is treated withtoluene, toluene is distilled out then pure product distilled out.
PROCESS FLOW DIAGRAM WITH MATERIAL BALANCE
Input Kg Output Kg
Bis (2 Chloroethyl) 100 amine HCl Tolune Fresh 10 Reaction Toluene Recovered 490 Reaction Mass 727 Caustic Soda 67 P - Anisidene 60 Total 727 Total 727
Reaction Mass 727 organic layer 720 Water 500 Extraction & Seperation Waste water to ETP 507
Total 1227 Total 1227
Product 100 Reaction Mass 720 Toluene recovered 490 Distillation Evaporation loss 5 Total 720 Residue 125 Total 720
ANNEXURE-6
23. N-PHENYL PIPERAZINE
PROCESS REACTION
NH2
NaOH Cl Cl NH NH + N
Bis(2-chloroethyl) amine .HCl
C4H9Cl2N.HCl Aniline N-phenyl piperazine 178.49 C6H7N C10H14N2 93.12 162.23 PROCESS
Aniline reacted with Bischloro Ethyl Amine Hydrochloride in toluene,Caustic Soda Lye added and separate product layer, solvent distilled outthen pure product distilled out.
PROCESS FLOW DIAGRAM WITH MATERIAL BALANCE
Input Kg Output Kg
Bis (2 Chloroethyl) amine 375 HCl Toluene fresh 10 toluene recovered 490Reaction Reaction Mass 1500 Caustic Soda LYE 50% 400 Aniline Oil 225
Total 1500 Total 1500
Reaction Mass 1500 Organic layer 914 Water 400Layer water to ETP 986 Seperation
Total 1900 Total 1900
Product 350 Reaction Mass 914 Toluene recovery 490 Distillation Evaporation loss 5 Residue 69 Total 914 Total 914
ANNEXURE-6
24. 2,3 DICHLOROPHENYLPIPERAZINE
CHEMICAL REACTION
NH2 Cl Cl Cl NaOH Cl Cl NH NH + N Cl Bis(2-chloroethyl) amine .HCl 2,3 Dichloro Aniline 2,3 Dichlorophenyl piperazine C4H9Cl2N.HCl C6H5Cl2N 178.49 162.01 C10H12N2Cl2 231.12 PROCESS
2, 3 – di chloro aniline reacted with Bischloro phenyl aniline hydrochloride to get 2, 3 – di chloro phenyl piperazine. Product separate out with solvent and solvent distilled out then pure product distilled out.
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Bis (2 Chloroethyl) amine 100 HCl Toluene Fresh 10 Reaction Toluene Recovered 490 Reaction Mass 910 Caustic Soda Lye 50% 160 2, 3 Dichloro Aniline 150 Total 910 Total 910
Reaction Mass 910 water to ETP 631 Water 500 Extraction & Organic Layer 779 Seperation
Total 1410 Total 1410
Product 100 Reaction Mass 779 Toluene recovery 490 Distillation Evaporation loss 5 Residue 184 Total 779 Total 779
ANNEXURE-6
25. 1,3-CHLOROPHENYL PIPERAZINE
CHEMICAL REACTION
NH2 Cl
NaOH Cl Cl NH NH + N Cl Bis(2-chloroethyl) amine .HCl m-Chloro aniline C H Cl N.HCl 3 Chlorophenyl piperazine 4 9 2 C H ClN 6 6 C H N Cl 178.49 127.57 10 13 2 196.67 PROCESS
Meta chloro aniline reacted with Bis 2- chloro ethyl aniline hydrochloride in solvent to get 1, 3 – chloro phenyl piperazine. It is separate with solvent and pure product distilled out.
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Bis (2 Chloroethyl) amine 100 HCl Toluene Fresh 10 Reaction Toluene Recovered 490 Reaction Mass 910 Caustic Soda Lye 50% 160 2, 3 Dichloro Aniline 150 Total 910 Total 910
Reaction Mass 910 water to ETP 631 Water 500 Extraction & Organic Layer 779 Seperation
Total 1410 Total 1410
Product 100 Reaction Mass 779 Toluene recovery 490 Distillation Evaporation loss 5 Residue 184 Total 779 Total 779
ANNEXURE-6
26.HYDROXY ETHYL PIPERAZINE
CHEMICAL REACTION
H N O + HN N N OH H Piperazine Ethylene Oxide Hydroxy Ethyl piperazine
C4H10N2 C2H4O C6H14N2O 86.13 44.05 130.18 PROCESS
Piperazine reacted with ethyl oxide to get Hydroxy ethyl piperazine then it is distilled out as pure product
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Piperazine Fresh 250 Piperazine Recovered 20 Reaction Mass 398 Reaction Ethylene Oxide 128
Total 398 Total 398
Reaction Mass 398 Product 378 Piperazine Recovered 20 Distillation
Total 398 Total 398
ANNEXURE-6
27.1-H-1,2,4 TRIAZOLE
CHEMICAL REACTION
H N N HCOOH + NH3 NH .NH + 2 2 N Formic acid Ammonia Hydrazine hydrate 1-H 1,2,4 Triazole 46.0 17.0 36.0 C2H3N3 69.06 PROCESS:-
Formic Acid reacts with ammonia to get Formaldehyde Further it is reactwith Hydrazine Hydrate get 1-H, 1,2,4-Triazole. MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
Formic Acid 880 Ammonia 125 Reaction Mass 1505
Reaction Hydrazine Hydrate (50%) 500
Total 1505 Total 1505
Reaction Mass 1505 Reaction mass 1105 Distilation Water to ETP 400
Total 1505 Total 1505
Reaction Mass 1105 wet cake 550 Centrifuge Effluent 555 Total 1105 Total 1105
wet cake 550 Water loss 50 Dryer Total 550 Product 500 Total 550
ANNEXURE-6
28. METHYL-3-AMINO CROTONATE
CHEMICAL REACTION
OO NH2 O
CH3 NH CH H C O + 3 3 3 H3C O Methyl acetoacetate Ammonia Methyl 3 Amino crotonate C H O 17.0 5 8 3 C5H9NO2 116.11 115.13 PROCESS
Methyl AcetoAcerate reaction with Liq. Ammonia in waterto get Methyl3 - Amino Crotonate semi solid material. MATERIAL BALANCE WITH FLOW DIAGRAM Input Kg Output Kg
Methyl Acetoacetae 100 Water -recovered 120Reaction Reaction Mass 238 Ammonia gas 18 Total 238 Total 238
Reaction Mass 238 Reaction Mass 107 Water 120 Centrifuging Ammonia 11
Total 238 Total 238
Reaction Mass 107Drying Dry Powder 100 Water 7 Total 107 Total 107
ANNEXURE-6
29.SODIUM-2-ETHYL HEXANOATE CHEMICAL REACTION
O O NaOH H C OH 3 H3C ONa
H C 3 H3C
2 Ethyl hexanoic acid Sodium 2 ethyl hexanoate C8H16O2 C8H15NaO2 144.21 166.19 PROCESS
2 - Ethyl Haxamic Acid reacted with Caustic Soda to get Sodium 2 EthylHexanoate water is distilled out then dried it in dryertoget packed.
ANNEXURE-6
MATERIAL BALANCE WITH FLOW DIAGRAM
Input Kg Output Kg
2 Ethyl Hexanoic Acid 100 Recovered Water 392 Water 8Reaction Reaction Mass 522 Caustic Soda 22
Total 522 Total 522
Reaction Mass 522 Reaction Mass 130 Water (reuse) 392 Distillation
Total 522 Total 522
Reaction Mass 130Centrifuging Wet Cake 120 Waste water to ETP 10 Total 130 Total 130
Reaction Mass 120 Dry Product 111 Drying Drying Loss 9
Total 120 Total 120
ANNEXURE-7
EXISTING FLOW DIAGRAM OF ETP PLANT:
Effluent from process
Neutralization Aeration tank Collection (10 KL) Tank Tank (10 KL) (10 KL) Effluent from utility blow down and Storage tank washing (3 nos)
ETP PROCESS:
Effluent from process and utility blow down is collected in collection tank which will be transferred into neutralization tank where it will be neutralized by using of HCl or Lime depends on effluent nature.After neutralization, neutral effluent will be treated in aeration tank where COD of the effluent will be reduced. Than after treated effluent is collected into storage tank.
1
ANNEXURE-7
EQUIPMENT LIST OF ETP
Sr. Name of unit EXISTING PROPOSED Capacity MOC
No.
1. Collection Tank 1 1 10 KL ACID PROOF BRICK
2. Neutralization 1 --- 10 KL ACID PROOF Tank BRICK
3. Aeration Tank 10 KL 40 KL ---- ACID PROOF BRICK
4. Storage Tank 2 2 5 KL HDPE
5. Storage Tank 1 1 10 KL HDPE
6. Pressure Sand --- 1 -- MS Filter
7. Carbon Tower --- 1 -- MS
8. 2-Stage RO --- 1 -- MS
2
ANNEXURE-7
PROPOSED EFFLUENT TREATMENT PLANT DESCRIPTION
• Unit will collect effluent from process and utility blow down into collection tank from where it will be transferred into neutralization tank for neutralizing purpose by using of HCl and Lime depends on effluent nature. After neutralization, neutral effluent will be treated in aeration tank and passed through pressure sand filter and carbon filter, so COD of effluent will be reduced. This low COD effluent will be passed through 2-Stage RO where RO-Permeate will be reused and RO-rejected will be send into ETL for further treatment.
3
ANNEXURE-7
PROPOSED ETP DIAGRAM
Effluent from Aeration tank process Collection Neutralization Tank Tank
Pressure Sand Filter
Effluent from utility blow down and washing Carbon Tower
2-stage RO
Collection Tank
Send to ETL
4
ANNEXURE-8
DETAILS OF WATER CONSUMPTION:
Sr. Particulate Water For Proposed Total water consumption after No. Consumption expansion proposed expansion as per CCA No. Fresh Recycle Fresh Recycle TOTAL AWH- 76585 in KL/Day 1. Domestic 1 2 0 3 0 3 2. Gardening 0.5 1.5 0 2 0 2 2. Industrial Process 5 0.1 29.9* 5.1 29.9* 35 Boiler 2 2 0 4 0 4 Cooling 1.5 -1.5 4* 0 4* 4 Washing 1.2 -1.2 3* 0 3* 3 others 0.250 -0.250 0 0 0 0 Total 9.95 -0.85 36.9* 9.1 36.9* 46 ( Industrial) TOTAL 11.45 2.65 36.9* 14.1 36.9* 51 ( Industrial TOTAL WATER (51 KL/DAY) + Domestic) (14.1 KL/DAY FRESH + 36.9 KL/DAY RECYCLE)
*Recycled from RO.
1
ANNEXURE-8
DETAILS OF WASTE WATER GENERATION:
Sr. Particulate Waste Water Generation Waste Water Total waste No. As per CCA No. AWH- Generation water 76585 in KL/Day after generation proposed after proposed expansion expasion 1. Domestic 0.90 1.8 2.7 2. Industrial Process 3 34 37 Boiler 0.15 0.65 0.8 Cooling 0.15 0.45 0.6 Washing 1.2 1.8 3 Total ( Industrial) 4.5 36.9 41.4* TOTAL ( Industrial + 5.4 38.7 44.1 Domestic)
*Total industrial effluent generation after proposed expansion will be 41.4 KL/Day. Unit will send 4.5 KL/Day effluent into ETL and remaining (36.9KL/Day) will be reused in washing, Cooling and Process after treatment.(RO permeate)
2
ANNEXURE-8
WATER BALANCE DIAGRAM
Total Water Consumption 51 KL/day (Fresh water=14.1 KL/Day + Recycle water=36.9 KL/Day)
Industrial TOTAL=48 KL/Day Domestic 3 KL/day Fresh water (11.1 KL/day) + Recycle water (36.9 KL/Day)
Sewage 2.7 KL/day Process Equipment and Gardening Cooling Boiler 35 KL/day floor washing 2 KL/day 4 KL/day 4 KL/day (5.1 fresh+ 3 KL/day (Recycle Water) 29.9 recycle) (Recycle water) Loss Loss 3.2 KL/day 3.4 KL/day
Effluent from Effluent from Cooling blow Boiler blow Process Washing down down 37 KL/day 3 KL/day 0.6 KL/day 0.8 KL/day
Send To Effluent Treatment Plant 41.4 KL/day
Soak pit /septic tank TO RO 2.7 KL/day RO permeate 36.9 KL/day 41.4 KL/Day
RO rejected
TO CETP 4.5 KL/day
3
ANNEXURE-9
FUEL CONSUMPTION (As per Existing CCA-AWH-76585)
SR. FUEL QUANTITY NO (As per current CCA No:-AWH-
1. Natural Gas* OR 100 m3/Day 2. LDO / Furnace oil* 300 Liter/Day
(TOTAL FUEL QUANTITY AFTER PROPOSED EXPANSION)
SR. FUEL TOTAL QUANTITY NO (Quantity after proposed expansion)
1. Natural Gas 600 m3/Day 2. LDO / Furnace oil 1500 Liter/Day 3. Diesel 15 Liter/Hr
*As per current CCA, either unit can use 100 m3/day natural gas or 300 liter/Day LDO/Furnace oil. After proposed expansion, unit will use both the fluid, Natural gas (600m3/day) and LDO/Furnace oil (1500 Liter/Day).Unit will also use Diesel for D.G.Set.(15 Lit/Hr).
ANNEXURE-9
POWER CONSUMPTION
SR. POWER QUANTITY QUANTITY TOTAL NO (As per proposed QUANTITY (As per current CCA expansion) No:-AWH-76585 1. Electricity 75 KW 225 KW 300 KW
ANNEXURE-10
HAZARDOUS WASTE GENERATION
Sr. Name of Category Quantity/ Quantity/ Total Treatment & No. Waste Year As Year As Quantity/Year Disposal per CCA per After No. Proposed proposed AWH- expansion 76585 1. Used Oil 5.1 0.030 MT 0.22 MT 0.25 MT Collection, Storage, Transportation, sell to registered Re refiners 2. Discarded 33.1 540 Nos. 1460 Nos. 2000 Nos. Collection, Containers Storage Decontamination, Reuse. 3. Residue 28.1 221 MT - - Collection, and wastes Storage, Transportation, Disposal by incinerator BEIL. 4. Spent 28.3 1 MT 4 MT 5 MT Collection, Carbon Storage, Transportation and Disposal at TSDF site BEIL. 5. ETP 35.3 27 MT 73 MT 100 MT Collection, Sludge Storage, Transportation and Disposal at TSDF site BEIL.
ANNEXURE-11
FLUE GAS EMISSION
Sr. Stack Stack Type Fuel Air Parameter Permissible No Attached Height in Pollution Limit To Meter Control System EXISTING EQUIPMENTS (as per CCA-AWH-76585) 1. Thermic Natural Gas --- PM 150 mg/NM3 Fluid heater SO 100 ppm X NOx 50 ppm
2. Baby Natural Gas --- PM 150 mg/NM3 15 Boiler SOX 100 ppm NOx 50 ppm
PROPOSED EQUIPMENTS
3 Boiler 15 Natural Gas--- PM 150 mg/NM3 SO 100 ppm (2 tons/hrs) X NOx 50 ppm
4 Thermic 15 LDO / --- PM 150 mg/NM3
Fluid heater Furnace SOX 100 ppm (4,00,000 oil/Natural NOx 50 ppm gas Kcal/hrs)
5. D.G.Set 11 Diesel --- PM 150 mg/NM3 SO 100 ppm (125 KVA) X NOx 50 ppm
ANNEXURE-12
PROCESS GAS EMISSION
Sr. Stack Stack Air Pollution Parameter Permissible No Attached To Height in Control Limit Meter System EXISTING PROCESS GAS EMISSION As per CCA-AWH-76585 1. Reaction 20 Alkali Scrubber HCl, 20 mg/Nm3 Vessel 3 Cl2 09 mg/Nm
PROPOSED PROCESS GAS EMISSION
2. Spin Flash 11 Bag Filter PM 150 mg/Nm3 Dryer
PROCESS GAS EMISSION AFTER PROPOSED EXPANSION
Sr. Stack Stack Air Parameter Permissible No Attached Height in Pollution Limit To Meter Control System 1. Reaction 20 Alkali HCl, 20 mg/Nm3 3 Vessel Scrubber Cl2 09 mg/Nm 2. Spin Flash 11 Bag Filter PM 150 mg/Nm3 Dryer
PROJECT PRE-FEASIBILITY REPORT
ON
PROPOSED PROJECT
FOR
MANUFACTURING OF API & ITS INTERMEDIATES, DYE INTERMEDIATES, FOOD AND NEUTRACUTICALS AND COSMETICS
OF M/s. JAY JALARAM ENTERPRISE AT PLOT NO:A-1/2402/02, GIDC ESTATE,ANKLESHWAR, DIST:BHARUCH STATE:-GUJARAT
1 M/s. JAY JALARAM ENTERPLRISE
CONTENTS
SR. No. Particulars Page No. 1 SUMMARY 7
2 INTRODUCTION 12
2.1 The Project 12
2.2 Project Proponent 12
2.3 Quality Policy 12
2.4 Environmental Policy 13
2.5 Nature of project 13
2.6 Market Feasibility 13
3 PROJECT DESCRIPTION 14
3.1 Type of Project 14
3.2 Project Location 14
3.3 Site selection 19
3.4 Neighbouring Industries 19
3.5 Size of project 19
3.6 Process Technology 20
3.7 Rawmaterial 20
3.8 Resource requirment 20
3.8.1 Land 20
3.8.2 Fuel Consumption 20
3.8.3 Water Consumption 21
3.8.3.1 Water Consumption 21
3.8.4 Waste Water Management 22
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SR. No. Particulars Page No. 3.8.4.1 Waste water characteristics 24
3.8.4.2 Waste water treatment and Disposal 24
3.9 Mitigation measures & EMP 24
3.9.1 Gaseous emission & Control 24
3.9.1.1 Flue gas emission 24
3.9.1.2 Process emission 25
3.9.2 Hazardous Waste Management 26
3.9.3 Noise control& odour 27
3.9.4 Storage ,handling and transport of Hazardous chemical 27
3.9.5 Health & Safety measures 27
4 SITE ANALYSIS 28
4.1 Connectivity 28
4.2 Land use and land ownership 28
4.3 Existing landuse 28
4.4 Existing infrasturcture 29
4.5 Soil Classification 29
4.6 Climate Data 29
4.7 Social Infrasturcture 31
5 PLANNING BRIEF 31
5.1 Planning concept 31
5.2 Population projection 32
5.3 Land use planning 32
6 PROPOSED INFRASTRUCTURE 32
6.1 Processing area 32
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SR. No. Particulars Page No. 6.2 Non processing area 32
6.3 Green belt area 32
6.4 Social Infrastructure 32
6.5 Connectivity 33
6.6 Drinking water management 33 6.7 Industrial waste managemnt 33 6.8 Solid waste management 33 6.9 Souce of power 33 7 REHABILITATION & RESETTLEMENT (R & R) PLAN 33 8 PROJECT SCHEDULE & COST ESTIMATES 33 8.1 Project Implementation Schedule 33 8.2 Estimated project cost 34 9 ANALYSIS OF PROPOSAL 34
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LIST OF TABLES
Table Topic Page No. No. 1. List of Products 8 2. Contact details of the Directors 13 3. Salient features of the Project Site 14 4. Nearby Industries in the vicinity 19 5. Capital cost of projection 19 6. Fuel requierment 20 7. Power Consumption 21 8. Water Consumption 21 9. Waste water generation 22 10 Fuel gas emission 24 11 Process gas emission 25 12 Details of hazardous waste 26 13. Man Power 28 14 Details of metrological. 29 15 Name of some prominent industries. 32 16 Projection implementation schedule 34
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LIST OF FIGURES
Sr. No. Description Page No.
1. Location of the Project Site 15-17 2. Aerial view of the 5 km radial periphery from the Project Sites 18 3. Wind rose 30-31
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1.0 EXECUTIVE SUMMARY M/s. Jay Jalaram Enterprise is located at plot no:-1/2402/02,Ankleshwar, Dist- Bharuch,Gujarat. Unit is having valid CCA-AWH-76585 for the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. Now unit wants to increase production, hence unit is going to apply for the EC on plot no. 1/2402/02, Ankleshwar, Dist- Bharuch. A detail of existing product is mentioned in below Table No.1.
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TABLE: 1
LIST OF PRODUCTS
Sr. Product Name Trade Name Existing Proposed Total No. Quantity Quantity Quantity as per MT/Month MT/Month CCA AWH- 76585 Valid Up To 25/06/2021 MT/Month GROUP-A API PRODUCTS (Each product not more than 40 MT/Month) 01 Bis(diethylthiocarbamoyl) disulfide Disulfiram 10 30 02 1,8-Diacetoxy-3-carboxyanthraquinone Diacerein 10 30 03 Bis[[(R)-3-carboxy-2- L-Carnitine 15 25 hydroxypropyl]trimethylammonium] L- Tartrate Tartrate 04 2,5-Dihydroxybenzenesulfonic acid Calcium 10 30 calcium salt Dobesilate 05 2,5-Dihydroxybenzenesulfonic acid Ehamsylate 15 25 40 MT Diethylamine salt (Either/or) 06 Valproic acid Valproic acid 15 25 07 (2E)-[(4R)-4-(2,4-dichlorophenyl)-1,3- Luliconazole - 40 dithiolan-2-ylidene]-(1H-imidazole-1- yl)ethanenitrile 08 3-[(2R,3R)-1-(dimethylamino)-2- Tapentadol - 40 methylpentan-3-yl]phenol 09 Five & Six Membered ring heterocyclic ------40 pharmaceuticals derivatives TOTAL (SR No:-1 to 9) (Total production will be 40 MT/Month) 40 MT/Month GROUP-B FOOD AND NEUTRACUTICAL PRODUCTS (Each product not more than 40 MT/Month) 10 L-2,5-Diaminopentanoic acid-L-2- L-Ornithine- 15 25 Aminobutanedioic acid L-Aspartate 11 L- -glutamyl-L-cysteinyl-glycine L-Glutathion 15 25 40 MT 12 (2R)-2-acetamido-3-sulfanylpropanoic N-Acetyl 15 25 (Either/or) acid cysteine 13 Methyl sulphone Monosulphone 10 30 methane
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14 2-Aminobutanedioic acid Calcium salt Calcium 15 25 aspartate 15 Sodium iron (III) ethylene diamine tetra Sodium - 40 acetate Feredetate 16 Calcium salt of 2,6-dioxo-1,2,3,6- Calcium salt - 40 tetrahydro-pyrimidine-4-carboxylic of Orotic acid acid 17 Amino acids, its salts and acetylated ------40 derivatives TOTAL (Sr No:-10 to 17) (Total production will be 40 MT/Month) 40 MT/Month GROUP-C COSMETIC PRODUCTS (Each product not more than 40 MT/Month) 18 2- palmitoyloxymethyl-5- Kijic acid 15 25 palmitoyloxy-y-pyrone Dipalmitate 19 6-palmitoyl-3-keto-L- Ascorbyl 10 30 gulofuranolactone Palmitate 40 MT 20 4-t-butyl-4’-methoxy-dibenzoyl Avobenzon - 40 (Either/or) methane 21 2-(hydroxymethyl)-6-(4- Arbutin - 40 hydroxyphenoxy)tetrahydro-2H-3,4,5- triol TOTAL(Sr No:-18 to 21) (Total production will be 40 MT/Month) 40 MT/Month GROUP-D API AND DYES INTERMEDIATE PRODUCTS (Each product not more than 40 MT/Month) 22 Barbituric Acid ------15 25 23 Bis (2-chloroethyl) amine .HCl ------15 25 24 1-(4-Methoxy phenyl)Piperazine ------10 30 25 N-Phenyl Piperazine ------10 30 26 2,3 Dichlorophenylpiperazine ------10 30 40 MT 27 1,3-Chlorophenyl Piperazine ------10 30 (Either/or) 28 Hydroxy ethyl Piperazine ------15 25 29 1-H-1,2,4 triazole ------15 25 30 Methyl-3-Amino crotonate ------15 25 31 Sodium-2-ethyl hexanoate ------10 30 TOTAL (Sr No:- 22 to 31) (Total production will be 40 MT/Month) 40 MT/Month GROUP-E R&D PRODUCT (Each product-2 MT/Month) 32 Inorganic R&D Product ------2 2 MT/Month 33 Organic R&D Product ------2 2 MT/Month TOTAL 4
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MT/MONTH TOTAL(Group-A+ Group-B+ Group-C+ Group-D+ Group-E) 164 MT/Month
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COST OF PROJECT
The expansion will be carried out at existing plot in GIDC Estate, Ankleshwar Gujarat. The total cost of the unit after proposed expansion is Rs 325 lacs.
FUEL AND ELECTRICITY CONSUMPTION
As per current CCA, either unit can use 100 m3/day natural gas or 300 liter/Day LDO/Furnace oil. After proposed expansion, unit will use both the fluid, Natural gas (600m3/day) and LDO/Furnace oil (1500 Liter/Day).Unit will also use diesel for D.G.Set(15 Lit/Hr). Unit is consuming 75 KWH electricity in existing condition which will be reached to 300 KWH after proposed expansion.
WATER CONSUMPTION
Unit can use 11.45 KL/Day fresh water as per existing CCA-AWH-76585.After proposed expansion it will be reached at 14.1 KL/Day. Unit will also use 36.9 KL/Day RO permeate water.
WASTEWATER GENERATION Total industrial effluent generation after proposed expansion will be 41.4 KL/Day. Unit will send 4.5 KL/Day effluent into ETL and remaining (36.9KL/Day) will be reused in washing, Cooling and Process after treatment.(RO permeate).
FLUE GAS EMISSION Existing flue gas emission machineries are Thermic Fluid Heater and Baby Boiler. Unit will install additional 1-Thermic fluid heater and 1-Boiler.
PROCESS GAS EMISSION Process gas machineries are Spin flash dryer and reactor.
HAZARDOUS WASTE MANAGEMENT Hazardous waste generation from the unit is ETP sludge, discarded bag/liners, Used/Spent oil.
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2. INTRODUCTION 2.1 THE PROJECT M/s. Jay Jalaram Enterprise is located at plot no:-1/2402/02,Ankleshwar, Dist- Bharuch,Gujarat. Unit is having valid CCA-AWH-76585 for the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. Unit falls in category 5 (f).Unit is located in notified industrial area so it a B category project but due to the absence of SEAC committee, unit has considered this project as “Category-A” project, hence unit requires to take prior permission from MoEF.
2.2 PROJECT PROPONENT M/s. Jay Jalaram Enterprise is located at plot no:-1/2402/02,Ankleshwar, Dist- Bharuch,Gujarat. Unit is having valid CCA-AWH-76585 for the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. The promoters have well experienced in this field. Now to meet the market demand promoters want to increase the production capacity of the unit. The plant boasts of contemporary infrastructure facilities with advanced machinery and automated processes. They are conscious of environment protection measures and from the conception stage itself necessary care has been taken. The unit believes in sustainable development and equally concern about environment preservation and pollution control. The unit has already provided adequate Environment Management System to meet desired norms of effluent discharge as per the statutory recruitment and also propose to expand its continuous endeavor for the pollution prevention and betterment of environment. A vision, a mission and a will to succeed are the basic ingredients in the foundation of the company. A team of well-qualified engineers and financial experts supports the company. Main promoters as well as staff of the company have very good industrial as well as business experience.
QUALITY POLICY The company’s commitment is to manufacturing of API(Bulk Drugs), Pharma and Dye Intermediates, Food and Neutracuticals and Cosmetic Products.. The company has in house testing facility with modern testing equipments to ascertain the quality of raw materials as well 12 M/s. JAY JALARAM ENTERPLRISE
as finished products. Continued emphasis towards process and technology up gradation is being done effectively to enrich the product quality. R & D with initiative & innovative ideas had resulted into excellent performance in respect of quality products.
ENVIRONMENTAL POLICY The unit is committed to execute all operations, products and services by environmental protection activities to the extent possible. As a means of achieving these, the unit pledge to company with the legal & other requirements to their core and focus on continually improving products, systems & operations.
TABLE: 2 CONTACT DEAILS OF PARTNERS
Sr. Name of the Designation Address Contact No. No. Director 1. Mr. PARAS DOSHI PARTNER A-50 GUJARAT 9312214732 APARTMENT, PITAMPURA, NEW DELHI 110034 1. Mr. SHAILEN PARTNER A-34 GUJARAT 9312872110 DOSHI APARTMENT, PITAMPURA, NEW DELHI 110034
The directors of the company have good experience in handling the production management, financial management. 2.3 NATURE OF PROJECT Unit falls in category 5 (f).Unit is located in notified industrial area so it a B category project but due to the absence of SEAC committee, unit has considered this project as “Category-A” project, hence unit requires to take prior permission from MoEF.
2.4 MARKET FEASIBILITY Proposed expansion shall bring in additional quantity for domestic market.
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3.0 PROJECT DESCRIPTION 3.1 TYPE OF PROJECT M/s. Jay Jalaram Enterprise is located at plot no:-1/2402/02,Ankleshwar, Dist- Bharuch,Gujarat. Unit is having valid CCA-AWH-76585 for the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics.
3.2 PROJECT LOCATION M/s. Jay Jalaram Enterprise is located at plot no:-1/2402/02,Ankleshwar, Dist- Bharuch, Gujarat. Unit is having valid CCA-AWH-76585 for the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics.The approximate geographical positioning of the project site is at Latitude: 21°37'12.48"N, Longitude: 73° 1'26.57"E. The location of the project site can be identified from the location map shown in Figure no.1&2. The salient features of the project site are presented in below Table-No.3. TABLE: 3 SALIENT FEATURES OF THE PROJECT SITE Particulars Details Distance from Site Villages Ankleshwar 3 KM Approx.Geographical Latitude: 21°37'12.48"N positioning Longitude: 73° 1'26.57"E Nearest City Ankleshwar 3 KM Bharuch 15 KM Nearest Railway line/ Ankleshwar 3 KM Railway station Domestic Airport Vadodara 94 KM
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FIGURE -1 LOCATION OF THE PROJECT SITE
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Ankleshwar
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FIGURE: 2
AERIAL VIEW OF THE 5 KM RADIAL PERIPHERY FROM THE PROJECT SITE
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3.3 SITE SELECTION The project proponent did not consider any other alternative site for proposed project. 3.4 NEIGHBORING INDUSTRIES The industry is located in an area, which is already industrialized. The industries in the vicinity of the proposed project are given in the table-4 below: TABLE: 4 NEARBY INDUSTRIES IN THE VICINITY
Sr. No. Industries Name 1 M/s. Heavy Metals 2 M/s.Auroma Industries 3. M/s. Suyog Dye Chem
3.5 SIZE OF PROJECT The unit has proposed expansion of manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. The unit has proposed to modify effluent treatment plant which will be maintained as per requirements. The break-up of the proposed project cost is given in below Table No. 5. TABLE: 5
CAPITAL COST PROJECTION
Sr. Purpose No. (Rs. In Lacs) 1. Building 90 2. Plant and Machinery 155 3. QC and R&D 50 4. Environment Protection & Safety
I) Effluent Treatment Plant 10 II) Safety Equipment 10 III) Green Belt Development 10 Total 325
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3.6 PROCESS TECHNOLOGY Unit is involving in the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. These are characterized for their physicochemical properties. Process details like Process description, chemical reactions and mass balance for each product is attached as Annexure-6 of FORM-I. 3.7 RAW MATERIAL Unit is involving in the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. Detail of Raw material consumption is attached as Annexure-5 of FORM-I. 3.8 RESOURCE REQUIREMENTS 3.8.1 LAND The total plot area of the unit is 3834.34 Sqmeter. Unit has allotted 779.32 Sqmeter for green belt development. 3.8.2 FUEL For production activity, fuel requirement and Power consumption is as per below table 6 and table 7. TABLE: 6 FUEL CONSUMPTION
SR. FUEL TOTAL QUANTITY NO (Quantity after proposed expansion)
1. Natural Gas 600 m3/Day 2. LDO / Furness oil 1500 Liter/Day 3. Diesel 15 lit/hr
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TABLE: 7 POWER CONSUMPTION
SR. POWER QUANTITY QUANTITY TOTAL NO (As per proposed QUANTITY (As per current CCA expansion) No:-AWH- 1. Electricity 75 KW 225 KW 300 KW
3.8.3 WATER 3.8.3.1 WATER CONSUMPTION Existing water and Proposed water consumption is incorporated in Table No:-8 TABLE: 8 WATER CONSUMPTION Sr. Particulate Water For Proposed Total water consumption after No. Consumption expansion proposed expansion as per CCA No. Fresh Recycle Fresh Recycle TOTAL AWH- 76585 in KL/Day 1. Domestic 1 2 0 3 0 3 2. Gardening 0.5 1.5 0 2.0 0 2 2. Industrial Process 5 0.1 29.9* 5.1 29.9 35 Boiler 2 2 0 4 0 4 Cooling 1.5 -1.5 4* 0 4 4 Washing 1.2 -1.2 3* 0 3 3 others 0.250 -0.250 0 0 0 0 Total 9.95 -0.85 36.9* 9.1 36.9* 46 ( Industrial) TOTAL 11.45 2.65 36.9* 14.1 36.9* 51 ( Industrial TOTAL WATER (51 KL/DAY) + Domestic) (14.1 KL/DAY FRESH + 36.9 KL/DAY RECYCLE)
*Recycled from RO.
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3.8.4 WASTEWATER MANAGEMENT The category-wise bifurcation of the wastewater generation is given in Table 9. TABLE: 9 WASTE WATER GENERATION
Sr. Particulate Waste Water Generation Waste Water Total waste No. As per CCA No. AWH- Generation water 76585 in KL/Day after generation proposed after proposed expansion expasion 1. Domestic 0.90 1.8 2.7 2. Industrial Process 3 34 37 Boiler 0.15 0.65 0.8 Cooling 0.15 0.45 0.6 Washing 1.2 1.8 3 Total ( Industrial) 4.5 36.9 41.4* TOTAL ( Industrial + 5.4 38.7 44.1 Domestic)
*Total industrial effluent generation after proposed expansion will be 41.4 KL/Day. Unit will send 4.5 KL/Day effluent into ETL and remaining (36.9KL/Day) will be reused in washing, Cooling and Process after treatment.(RO permeate)
22 M/s. JAY JALARAM ENTERPLRISE Total Water Consumption 51 KL/day (Fresh water=14.1 KL/Day + Recycle water=36.9 KL/Day)
Domestic Industrial TOTAL=48 KL/Day 3 KL/day Fresh water (11.1 KL/day) + Recycle water (36.9 KL/Day)
Sewage 2.7 KL/day Process Equipment and Gardening Cooling Boiler
35 KL/day floor washing 2 KL/day 4 KL/day 4 KL/day (5.1 fresh+ 3 KL/day (Recycle Water) 29.9 recycle) (Recycle water) Loss Loss 3.2 KL/day 3.4 KL/day
Effluent from Effluent from Cooling blow Boiler blow Process Washing down down 37 KL/day 3 KL/day 0.6 KL/day 0.8 KL/day
Send To Effluent Treatment Plant 41.4 KL/day
Soak pit /septic tank TO RO 2.7 KL/day RO permeate 36.9 KL/day 41.4 KL/Day
RO rejected
TO CETP 4.5 KL/day
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3.8.4.1 WASTEWATER CHARACTERISTICS Existing & proposed effluent characteristic before treatment and after treatment in ETP is covered in Annexure-7 of FORM I.
3.8.4.2 WASTEWATER TREATMENT & DISPOSAL
A detail of existing & proposed effluent treatment plant (ETP) is covered in Annexure-7 of FORM I. 3.9 MITIGATION MEASURES & EMP Based on overall manufacturing & operation activities, the mitigation measures have been proposed by the company for the control of the anticipated pollution load. 3.9.1 GASEOUS EMISSIONS & CONTROL 3.9.1.1 FLUE GAS EMISSION Existing flue gas emission and proposed flue gas emission is mentioned in Table No: 10. TABLE: 10 FLUE GAS EMISSION Sr. Stack Stack Type Fuel Air Parameter Permissible No Attached Height Pollution Limit To in Meter Control System EXISTING EQUIPMENTS(as per CCA-AWH-76585) 1. Thermic Natural --- PM 150 mg/NM3 Fluid Gas SOX 100 ppm heater NOx 50 ppm Baby 15 Boiler 2. Natural --- PM 150 mg/NM3 Gas SOX 100 ppm NOx 50 ppm PROPOSED EQUIPMENTS 3 Boiler 15 Natural --- PM 150 mg/NM3 (2 Gas SOX 100 ppm tons/hrs) NOx 50 ppm 4 Thermic 15 LDO / --- PM 150 mg/NM3 Fluid Furnace SOX 100 ppm heater oil/Natural NOx 50 ppm (4,00,000 gas Kcal/hrs)
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5. D.G.Set 11 Diesel --- PM 150 mg/NM3 (125 SOX 100 ppm KVA) NOx 50 ppm
3.9.1.2 PROCESS EMISSIONS
Existing process gas emission and proposed flue gas emission is mentioned in Table No: 11.
TABLE:-11 PROCESS GAS EMISSION
Sr. Stack Attached To Stack Air Parameter Permissible No Height in Pollution Limit Meter Control System EXISTING PROCESS GAS EMISSION EQUIPMENT 1. Reaction Vessel 20 Alkali HCl, 20 mg/Nm3 3 Scrubber Cl2 09 mg/Nm PROPOSED PROCESS GAS EMISSION 2. Spin Flash Dryer 11 Bag Filter PM 150 mg/Nm3
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3.9.2 HAZARDOUS WASTE MANAGEMENT
The following types of hazardous wastes are being generated during the operational activities. All the wastes are being stored separately in a designated storage area. The details of hazardous waste are below given Table 12.
TABLE 12 DETAILS OF HAZARDOUS WASTE Sr. Name of Category Quantity/ Quantity/ Total Treatment & No. Waste Year As Year As Quantity/Year Disposal per CCA per After No. Proposed proposed AWH- expansion 76585 1. Used Oil 5.1 0.030 MT 0.22 MT 0.25 MT Collection, Storage, Transportation, sell to registered Re refiners 2. Discarded 33.1 540 Nos. 1460 Nos. 2000 Nos. Collection, Containers Storage Decontamination, Reuse. 3. Residue and 28.1 221 MT - - Collection, wastes Storage, Transportation, Disposal by incinerator BEIL. 5. Spent Carbon 28.3 1 MT 4 MT 5 MT Collection, Storage, Transportation and Disposal at TSDF site BEIL. 6. ETP Sludge 35.3 27 MT 73 MT 100 MT Collection, Storage, Transportation and Disposal at TSDF site BEIL.
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3.9.3 NOISE CONTROL & ODOUR The major noise generating installation is the D.G. Set. Unit has installed it in a closed room and provided acoustic enclosure around it. Unit has also provided ear plugs to the operating person of Boiler room.
Unit is following below steps to Noise control and Odour. • Raw-material feeding is being carried out by pumps. • All reactions are being taken in closed reactor system. • Roof top ventilation is installed in the entire plant area. • Regular monitoring of piping and fittings is carried out to prevent the leakages. 3.9.4 STORAGE, HANDLING AND TRANSPORT OF HAZARDOUS CHEMICALS The storage and mode of transport of chemicals are being done as per detailed MSDS and chemical hazards guide (NIOSH) for the hazardous chemicals. Few chemical to be used in the proposed activities are listed as ‘Hazardous Chemicals’ as per the Schedule-1 of the MSIHC Rules, as amended in 2000.
3.9.5 HEALTH AND SAFETY MEASURES Few chemical to be used in the proposed activities are listed as ‘Hazardous Chemicals’ as per the Schedule-1 of the MSIHC Rules, as amended in 2000. Physical hazards may manifest as fires, explosions, excessive temperatures, or the release of large volumes of gas or toxic or flammable gases or vapors. According to Schedule 2 & 3 of MSIHC Rules, Moreover transport activity is being done through drums, so there is a manual loading and unloading and no unloading through pipe at the site. Hence, the risk of static charge generation during transfer of such chemicals is not significant. 3.9.6 MAN POWER The manpower required for the project as well as during the construction/ commissioning activities will be employed from the local area.
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TABLE NO:-13 MAN POWER REQUIREMENT Sr. Headings Existing Proposed work Total after no. work force force expansion 1. Technical Managerial 03 03 06 level & Administrative Manager level 2. Technical skilled staff 06 08 14 3. Unskilled staff 12 15 27 4. Others – security, 02 01 03 gardener, etc Total 23 27 50
4.0 SITE ANALYSIS 4.1 CONNECTIVITY Ankleshwar is known for Pigment and Pharmaceutical Industry. Ankleshwar is connected by Indian National Highway 8 (Mumbai to New Delhi) and by the Western Railway Division of Indian Railways. The railway division runs the broad gauge train services to Rajpipla. The 133-year-old Golden Bridge connects Ankleshwar to Bharuch across the Narmada on the station front while a new bridge connects the highway, the other bridge on the highway is now ready to use. Ankleshwar railway station is centrally located at the intersection of NH8 & Station Road. Ankleshwar City Bus stand is located on Station Road (i.e. located in the City, the western section).Development projects of Ankleshwar Airport & City Bus are in last stage.
4.2 LAND USE AND LAND OWNERSHIP M/s. Jay Jalaram Enterprise is located at plot no:-A-1/2402/02, Ankleshwar, Dist- Bharuch, Gujarat. 4.3 EXISTING LAND USE M/s. Jay Jalaram Enterprise is located at plot no:-A-1/2402/02, Ankleshwar, Dist- Bharuch, Gujarat. Unit is having valid CCA-AWH-76585 for the the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics.
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4.4 EXISTING INFRASTRUCTURE The plant is located in a well-developed industrial zone, which has all essential facilities such as internal roads, arrangement for supply of water and power to industries, effluent disposal facilities, gas etc. The proposed project is relatively small in size and will be employing some skilled and unskilled people. First preference will be given to local people, so there will be no change in population pattern due to the proposed project.
4.5 SOIL CLASSIFICATION
The soil of the district can be classified as light, medium and heavy according to depth, texture and location. There is sandy loam to loamy in texture, brownish black in color.
4.6 CLIMATE DATA
Based on the meteorological data, wind rose have been prepared for the summer season period between the Oct-2016 to Dec-2016. The wind rose diagram prepared from same data is shown at Figure 3, Figure 3.1. TABLE: 14 METEOROLOGICAL DATA Month -- Temp. (°C) Relative Wind Speed Humidity (%) km/hr October-16 Min. 23 28 0 Max. 35 94 13 Average 29 61 6.5 November-16 Min. 20 24 0 Max. 34 51 10 Average 27 37.5 5 December-16 Min. 17 23 0 Max. 32 52 11 Average 24.5 37.5 5.5
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FIGURE: 3 WIND ROSE DIAGRAM FOR PERIOD OF OCTOBER-2016 TO DECEMBER-2016
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FIGURE: 3.1 WIND CLASS FREQUENCY DISRTIBUTION
.
Observation: It observed that wind is blowing mainly towards the SW direction from NE. Average wind speed was 2.38 m/s. 4.7 SOCIAL INFRASTRUCTURE As of 2011 India census, Ankleshwar had a population of 140,839. Males constitute 53% of the population and females 47%. 13% of the population is under 6 years of age. 5.0 PLANNING BRIEF
5.1 PLANNING CONCEPT:
Ankleshwar is largely an industrial area dominated by large scale industries, especially chemical Plants. Government agencies provide many basic facilities like uninterrupted water supply, power and road network.
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5.2 POPULATION PROJECTION.
As of 2011 India census, Ankleshwar had a population of 140,839. Males constitute 53% of the population and females 47%. 13% of the population is under 6 years of age.
5.3 LAND USE PLANNING
The names of prominent industries are shown in table no: 15 TABLE: 15 NAME OF SOME PROMINENT INDUSTRIES Sr. No. Name of industry 1) M/s.Heavy Metals 2) M/s.Auroma Industries 3) M/s.Suyog Dye Chem
6.0 PROPOSED INFRASTRUCTURE 6.1 PROCESSING AREA The process area is covered plant area, raw material storage area, hazardous waste storage area, workshop and utilities. 6.2 NON PROCESSING AREA The non process area is covered Admin Building, toilet blocks, change room and security cabin. 6.3 GREEN BELT AREA M/s. Jay Jalaram Enterprise Sis located at plot no:-A-1/2402/02, Ankleshwar, Dist- Bharuch, Gujarat. Unit is having valid CCA-AWH-76585 for the the manufacturing of API & its intermediates, Dye Intermediates, Food and Neutracuticals and Cosmetics. The total plot area of the unit is 3834.34 sq meter in which 779.32 sq meter is total green belt area. 6.4 SOCIAL INFRASTRUCTURE The availability of basic amenities is covered as under:
• Training & Education: All the employees are being trained and educated periodically about the hazardous nature of chemicals used in the process. Also, training for fire fighting, work permits system, first aid, safe handling of hazardous chemicals and integrating safety, in all activities.
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• Medical facility: Pre-employment medical checkup at the time of employment. In order to safe guard the health of the employees, all the employees undergo periodic health checkup.
• Drinking water: Unit has provided Aqua Guard/R.O at different places to provide purified water for drinking purpose.
• Transportation: The unit is providing basic transportation facility to workers.
• Telegraph & Post: Unit has all the facilities like telephone, fax and internet for the employees.
6.5 CONNECTIVITY This industrial estate is well connected to Ahmadabad/Mumbai/Vadodara through the Ankleshwar. Rail services and Road services are available in Ankleshwar.
6.6 DRINKING WATER MANAGEMENT Average daily water consumption of unit is 3 KL/day for domestic purpose. GIDC water is a source of domestic water. 6.7 INDUSTRIAL WASTE MANAGEMENT The hazardous waste management and disposal is shown in table 12. 6.8 SOLID WASTE MANAGEMENT The Solid waste management and disposal is shown in table 12. 6.9 SOURCE OF POWER DGVCL is a main source of Power. 7.0 REHABILITATION AND RESETTLEMENT(R &R) PLAN The proposed project is located in GIDC Estate, Ankleshwar. There will be no any human settlement affected by proposed project. So, there is no requirement of any R & R Plan. 8.0 PROJECT SCHEDULE & COST ESTIMATES 8.1 PROJECT IMPLEMENTATION SCHEDULE The details of project Implementation Schedule is given in below table.
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TABLE: 16 PROJECT IMPLEMENTATION SCHEDULE Project implementation schedule after getting NOC from GPCB Sr. No. Activity Required Period 1. Civil work Immediately after getting NOC 2. Procurement of machinery 1 month after getting NOC
3. Eraction & installation of Immediately after competition of activity no.2 machinery 4. Trial of machinery & Within 1 months after competition of activity equipment no.3 5. Commercial activity 1 months after competition of activity no.4
8.2 ESTIMATED PROJECT COST The details of Capital cost projection are given in table no. 6. 9.0 ANALYSIS OF PROPOSAL First preference will be given to local people for employment and Company will also try to provide indirect employment opportunities by availing local contract services during transportation and operational phase. The company intents to donate 2 % of the profit to agencies like NGOs or social welfare societies for projects carried out in nearby villages for their welfare and upliftment.
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