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Weighing the Trade-Offs of a Direct Presence in Japan's Rare And
Special Report Weighing the Trade-offs of a Direct Presence in Japan’s Rare and Orphan Drug Market January 2020 Contents Summary ................................................................2 Background on increasing interest in Japan among rare and orphan biopharma companies ....................3 Attractive market fundamentals at the heart of the opportunity ............................................................4 Retaining control helps avoid poor partnering outcomes and entanglements ..................................6 The market is not without its challenges ...................7 A direct presence will not make business sense for everyone ............................................................. 10 Checklist for prospective Japan entrants ................. 11 Endnotes/About the Authors ................................. 12 About L.E.K. Consulting L.E.K. Consulting is a global management consulting firm that uses deep industry expertise and rigorous analysis to help business leaders achieve practical results with real impact. We are uncompromising in our approach to helping clients consistently make better decisions and deliver improved performance. The firm advises and supports organizations that are leaders in their sectors, including the largest private and public sector organizations, private equity firms, and emerging entrepreneurial businesses. Founded in 1983, L.E.K. employs more than 1,600 professionals across the Americas, Asia-Pacific and Europe. For more information, go to www.lek.com. 1 Summary Japan has long sought to foster an attractive market for orphan you consider the benefits of avoiding entanglement with a drugs, with specific provisions made to encourage the development partner and the challenges of managing relationships with of therapies for rare and orphan diseases as early as 1972.1 The potential licensing partners. measures and incentives that followed made the orphan and rare • But setting up a direct presence in Japan is not for model economically viable in Japan, yet companies operating in everyone. -
Exploring the Experiences of Gamers Playing As Multiple First-Person Video Game Protagonists in Halo 3: ODST’S Single-Player Narrative
Exploring the experiences of gamers playing as multiple first-person video game protagonists in Halo 3: ODST’s single-player narrative Richard Alexander Meyers Bachelor of Arts Submitted in fulfilment of the requirement for the degree of Master of Arts (Research) School of Creative Practice Creative Industries Faculty Queensland University of Technology 2018 Keywords First-Person Shooter (FPS), Halo 3: ODST, Interpretive Phenomenological Analysis (IPA), ludus, paidia, phenomenology, video games. i Abstract This thesis explores the experiences of gamers playing as multiple first-person video game protagonists in Halo 3: ODST, with a view to formulating an understanding of player experience for the benefit of video game theorists and industry developers. A significant number of contemporary console-based video games are coming to be characterised by multiple playable characters within a game’s narrative. The experience of playing as more than one video game character in a single narrative has been identified as an under-explored area in the academic literature to date. An empirical research study was conducted to explore the experiences of a small group of gamers playing through Halo 3: ODST’s single-player narrative. Interpretive Phenomenological Analysis (IPA) was used as a methodology particularly suited to exploring a new or unexplored area of research and one which provides a nuanced understanding of a small number of people experiencing a phenomenon such as, in this case, playing a video game. Data were gathered from three participants through experience journals and subsequently through two semi- structured interviews. The findings in relation to participants’ experiences of Halo 3: ODST’s narrative were able to be categorised into three interrelated narrative elements: visual imagery and world-building, sound and music, and character. -
2006 2012 2013 2014 Introducing HALO® 2 Fused-Core®
Introducing HALO® 2 Fused-Core® UHPLC Columns From Advanced Materials Technology Rugged ∙ High Efficiency ∙ Low Back Pressure HALO 2 Fused-Core particles are designed to address the disadvantages inherent in existing sub-2 micron non-core UHPLC columns. HALO 2 UHPLC columns have all of the advantages of sub-2 µm non-core particle columns and will deliver 300,000 plates per meter efficiency (higher than existing non-core sub-2 µm columns). Manufactured with 1.0 µm frits on the column inlet, HALO 2 columns are less susceptible to column plugging. These columns can be used up to 1,000 bar (14,500 psi), but will actually produce ~20% lower back pressure than most commercially available sub-2 µm UHPLC columns under the same conditions. 1 Advantages of HALO 2 Fused-Core Columns vs. Sub-2 µm Non-core UHPLC Columns · Fused-Core UHPLC columns with ~300K plates per meter · All of the advantages of sub-2 µm non-core particles at lower - Higher efficiency than existing non-core sub-2 µm columns operating pressures · Longer column lifetime – more injections, less downtime - High speed and efficiency with short columns - Due to Fused-Core 2 micron particle architecture, 1 micron - Improved productivity from faster analyses frits can be used on the column inlet - Less solvent usage from shorter analysis times - 1 micron frits are less likely to be plugged by UHPLC samples - High resolution and peak capacity in longer columns or mobile phase contaminants than typical 0.2 – 0.5 µm - Sharper, taller peaks = better sensitivity and lower LOD frits on sub-2 -
Ubisoft® Celebrates 30 Years of Creating Games at E3 2016
Ubisoft® Celebrates 30 Years of Creating Games at E3 2016 PARIS, FRANCE — June 2, 2016 — Today, Ubisoft reveals its plans for E3 2016, where its creative teams will proudly present highly anticipated titles such as Watch Dogs® 2, For Honor™ or Tom Clancy’s Ghost Recon® Wildlands. They’ll also detail new content coming for live games and – as usual – unveil some surprises. The week will kick off with Ubisoft’s E3 2016 Conference, taking place on Monday, June 13 starting at 1 p.m. PDT and preceded by a 30-minute pre-show. E3 attendees can experience Ubisoft games at its booth (booth #1023, South Hall, Los Angeles Convention Center) from June 14 – 16. More than 1,700 fans also have the opportunity to play Ubisoft games and meet the development teams at the fourth-annual Ubisoft Lounge. “E3 is always a very special moment when everyone in the entertainment business does their best to amaze and engage gamers. For Ubisoft’s teams, it’s a period of pride and of anxious anticipation because they are finally showing off the games they’ve poured so much passion into, and receiving feedback from players and peers. Our industry has evolved so much in the past 30 years, but what hasn’t changed is my love and respect for the limitless passion and talent of developers and players alike,” said Yves Guillemot, co-founder and CEO, Ubisoft. “The video game industry continues to enjoy strong momentum, with powerful new platforms that enable more creativity, expression and imagination. More than ever, video games are showing how they will shape the future of entertainment. -
Game Enforcer Is Just a Group of People Providing You with Information and Telling You About the Latest Games
magazine you will see the coolest ads and Letter from The the most legit info articles you can ever find. Some of the ads include Xbox 360 skins Editor allowing you to customize your precious baby. Another ad is that there is an amazing Ever since I decided to do a magazine I ad on Assassins Creed Brotherhood and an already had an idea in my head and that idea amazing ad on Clash Of Clans. There is is video games. I always loved video games articles on a strategy game called Sid Meiers it gives me something to do it entertains me Civilization 5. My reason for this magazine and it allows me to think and focus on that is to give you fans of this magazine a chance only. Nowadays the best games are the ones to learn more about video games than any online ad can tell you and also its to give you a chance to see the new games coming out or what is starting to be making. Game Enforcer is just a group of people providing you with information and telling you about the latest games. We have great ads that we think you will enjoy and we hope you enjoy them so much you buy them and have fun like so many before. A lot of the games we with the best graphics and action. Everyone likes video games so I thought it would be good to make a magazine on video games. Every person who enjoys video games I expect to buy it and that is my goal get the most sales and the best ratings than any other video game magazine. -
Pdf (Accessed 2.10.14)
Notes 1 Introduction: Video Games and Storytelling 1. It must be noted that the term ‘Narratological’ is a rather loose application by the Ludologists and the implications of this are pointed out later in this chapter. 2. Roland Barthes states that the ‘infinity of the signifier refers not to some idea of the ineffable (the unnameable signified) but to that of a playing [ ...] theText is plural’. Source: Barthes, R., 1977. Image, Music, Text, in: Heath,S.(Tran.), Fontana Communications Series. Fontana, London. pp. 158–159. 3.In Gaming Globally: Production, Play, and Place (Huntemann and Aslinger, 2012),theeditors acknowledgethat ‘while gaming maybe global, gaming cultures and practices vary widely depending on the power and voice of var- ious stakeholders’ (p. 27). The paucity of games studies scholarship coming from some of the largest consumers of video games, such as South Korea, China and India, to name a few, is markedly noticeable. The lack of represen- tation of non-Western conceptions of play culture and storytelling traditions is similarly problematic. 4. Chapter 8 will engage with this issue in more detail. 5. ‘(W)reading’ is preferred over the more commonly used neologism ‘wread- ing’toemphasise the supplementarity of the reading and writingprocesses and also to differentiate it from earlier usage that might claim that the two processes are the same thing. 3 (W)Reading the Machinic Game-Narrative 6. For whichhe is criticisedby Hayles (see Chapter 2). 7. Landow respondstothis by rightly stating that Aarseth misreads his original comment where heclaims that ‘the reader whochooses among linksortakes advantage of Storyspace’s hypertext capabilities shares some of the power of theauthor’(Landow, p. -
Fighting Games, Performativity, and Social Game Play a Dissertation
The Art of War: Fighting Games, Performativity, and Social Game Play A dissertation presented to the faculty of the Scripps College of Communication of Ohio University In partial fulfillment of the requirements for the degree Doctor of Philosophy Todd L. Harper November 2010 © 2010 Todd L. Harper. All Rights Reserved. This dissertation titled The Art of War: Fighting Games, Performativity, and Social Game Play by TODD L. HARPER has been approved for the School of Media Arts and Studies and the Scripps College of Communication by Mia L. Consalvo Associate Professor of Media Arts and Studies Gregory J. Shepherd Dean, Scripps College of Communication ii ABSTRACT HARPER, TODD L., Ph.D., November 2010, Mass Communications The Art of War: Fighting Games, Performativity, and Social Game Play (244 pp.) Director of Dissertation: Mia L. Consalvo This dissertation draws on feminist theory – specifically, performance and performativity – to explore how digital game players construct the game experience and social play. Scholarship in game studies has established the formal aspects of a game as being a combination of its rules and the fiction or narrative that contextualizes those rules. The question remains, how do the ways people play games influence what makes up a game, and how those players understand themselves as players and as social actors through the gaming experience? Taking a qualitative approach, this study explored players of fighting games: competitive games of one-on-one combat. Specifically, it combined observations at the Evolution fighting game tournament in July, 2009 and in-depth interviews with fighting game enthusiasts. In addition, three groups of college students with varying histories and experiences with games were observed playing both competitive and cooperative games together. -
Ubisoft Studios
CREATIVITY AT THE CORE UBISOFT STUDIOS With the second largest in-house development staff in the world, Ubisoft employs around 8 000 team members dedicated to video games development in 29 studios around the world. Ubisoft attracts the best and brightest from all continents because talent, creativity & innovation are at its core. UBISOFT WORLDWIDE STUDIOS OPENING/ACQUISITION TIMELINE Ubisoft Paris, France – Opened in 1992 Ubisoft Bucharest, Romania – Opened in 1992 Ubisoft Montpellier, France – Opened in 1994 Ubisoft Annecy, France – Opened in 1996 Ubisoft Shanghai, China – Opened in 1996 Ubisoft Montreal, Canada – Opened in 1997 Ubisoft Barcelona, Spain – Opened in 1998 Ubisoft Milan, Italy – Opened in 1998 Red Storm Entertainment, NC, USA – Acquired in 2000 Blue Byte, Germany – Acquired in 2001 Ubisoft Quebec, Canada – Opened in 2005 Ubisoft Sofia, Bulgaria – Opened in 2006 Reflections, United Kingdom – Acquired in 2006 Ubisoft Osaka, Japan – Acquired in 2008 Ubisoft Chengdu, China – Opened in 2008 Ubisoft Singapore – Opened in 2008 Ubisoft Pune, India – Acquired in 2008 Ubisoft Kiev, Ukraine – Opened in 2008 Massive, Sweden – Acquired in 2008 Ubisoft Toronto, Canada – Opened in 2009 Nadeo, France – Acquired in 2009 Ubisoft San Francisco, USA – Opened in 2009 Owlient, France – Acquired in 2011 RedLynx, Finland – Acquired in 2011 Ubisoft Abu Dhabi, U.A.E – Opened in 2011 Future Games of London, UK – Acquired in 2013 Ubisoft Halifax, Canada – Acquired in 2015 Ivory Tower, France – Acquired in 2015 Ubisoft Philippines – Opened in 2016 UBISOFT PaRIS Established in 1992, Ubisoft’s pioneer in-house studio is responsible for the creation of some of the most iconic Ubisoft brands such as the blockbuster franchise Rayman® as well as the worldwide Just Dance® phenomenon that has sold over 55 million copies. -
Game Narrative Review
Game Narrative Review ==================== Your name (one name, please): Kai McDonald Your school: DigiPen Institute of Technology Your email: [email protected] Month/Year you submitted this review: December 2019 ==================== Game Title: Halo Reach Platform: Xbox 360 Genre: First-person shooter Release Date: September 14th, 2010 Developer: Bungie Publisher: Microsoft Game Studios Game Writer/Creative Director/Narrative Designer: Marcus Lehto Overview Halo: Reach takes place in the distant future of the year 2552. Technology has progressed far beyond the imaginations of the modern day, and humanity finds itself at war. United under a single banner known as the United Nations Space Command (UNSC), Humans find themselves at odds with a cult of alien races known as the Covenant. Most of humanities’ interstellar colonies have fallen by the opening of the game. Players take on the burden of Noble Six, an elite UNSC super soldier joining the special operations unit known as Noble Team. The team has been tasked with investigating a communication station that has recently gone silent on the part UNSC hub, part human colony planet known as Reach. Thrown into a surprise invasion by the Covenant, the player faces tragedy after tragedy as team members make sacrifices, lose battles, and are subjected to the bleak realities of war. Halo: Reach is not a story of heroism and triumph. 1 It is one of failure, defeat, and most importantly, death. From the beginning, you know the end. Characters ● Noble Team – Composed of genetically enhanced UNSC super-soldiers known as “SPARTANS”, Noble Team served as the answer to UNSC’s hard questions regarding important missions. -
The Shadow Isle: a 3D Survival Virtual Reality Game Using A* Search Algorithm
Anna Liza A. Ramos et al, International Journal of Computer Science and Mobile Computing, Vol.8 Issue.4, April- 2019, pg. 217-225 Available Online at www.ijcsmc.com International Journal of Computer Science and Mobile Computing A Monthly Journal of Computer Science and Information Technology ISSN 2320–088X IMPACT FACTOR: 6.199 IJCSMC, Vol. 8, Issue. 4, April 2019, pg.217 – 225 The Shadow Isle: A 3D Survival Virtual Reality Game using A* Search Algorithm Anna Liza A. Ramos1; Lorenz E. Laza2; Laurence Dale M. Cartilla3; Yannah Mitch Z. Cayetano4; Rosebeth M. Roxas5; Jan Raymond T. Martin6 Institute of Computer Studies, Saint Michael’s College of Laguna 1 [email protected]; 2 [email protected]; 3 [email protected]; 5 [email protected]; 6 [email protected] Abstract— Virtual reality is the new emerging games where gamers experience a real world thus elicit emotional activation. The study aims to build a game model using Unity3D for building the game functionality, Blender for the character 3D model, ZBrush, Autodesk for character sketching, Photoshop for character enhancement, and VR box for viewing the game environment and the application of the A* search algorithm in the game. Furthermore, the prototype game model was evaluated by five (5) game developers and ten (10) gamers using the criterion on the Clarity of Rules, Flow, Strategy Luck, Balance, Length, Theme and Mechanics Integration, Tension and Fun. In result the game prototype marked an over-all performance result of 83.22% specifically recorded highest score in two (2) criterion on for both strategy, luck and balance and tension fun of 93.33%. -
Inside the Video Game Industry
Inside the Video Game Industry GameDevelopersTalkAbout theBusinessofPlay Judd Ethan Ruggill, Ken S. McAllister, Randy Nichols, and Ryan Kaufman Downloaded by [Pennsylvania State University] at 11:09 14 September 2017 First published by Routledge Th ird Avenue, New York, NY and by Routledge Park Square, Milton Park, Abingdon, Oxon OX RN Routledge is an imprint of the Taylor & Francis Group, an Informa business © Taylor & Francis Th e right of Judd Ethan Ruggill, Ken S. McAllister, Randy Nichols, and Ryan Kaufman to be identifi ed as authors of this work has been asserted by them in accordance with sections and of the Copyright, Designs and Patents Act . All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Trademark notice : Product or corporate names may be trademarks or registered trademarks, and are used only for identifi cation and explanation without intent to infringe. Library of Congress Cataloging in Publication Data Names: Ruggill, Judd Ethan, editor. | McAllister, Ken S., – editor. | Nichols, Randall K., editor. | Kaufman, Ryan, editor. Title: Inside the video game industry : game developers talk about the business of play / edited by Judd Ethan Ruggill, Ken S. McAllister, Randy Nichols, and Ryan Kaufman. Description: New York : Routledge is an imprint of the Taylor & Francis Group, an Informa Business, [] | Includes index. Identifi ers: LCCN | ISBN (hardback) | ISBN (pbk.) | ISBN (ebk) Subjects: LCSH: Video games industry. -
Game Developers Conference Europe Wrap, New Women’S Group Forms, Licensed to Steal Super Genre Break Out, and More
>> PRODUCT REVIEWS SPEEDTREE RT 1.7 * SPACEPILOT OCTOBER 2005 THE LEADING GAME INDUSTRY MAGAZINE >>POSTMORTEM >>WALKING THE PLANK >>INNER PRODUCT ART & ARTIFICE IN DANIEL JAMES ON DEBUG? RELEASE? RESIDENT EVIL 4 CASUAL MMO GOLD LET’S DEVELOP! Thanks to our publishers for helping us create a new world of video games. GameTapTM and many of the video game industry’s leading publishers have joined together to create a new world where you can play hundreds of the greatest games right from your broadband-connected PC. It’s gaming freedom like never before. START PLAYING AT GAMETAP.COM TM & © 2005 Turner Broadcasting System, Inc. A Time Warner Company. Patent Pending. All Rights Reserved. GTP1-05-116-104_mstrA_v2.indd 1 9/7/05 10:58:02 PM []CONTENTS OCTOBER 2005 VOLUME 12, NUMBER 9 FEATURES 11 TOP 20 PUBLISHERS Who’s the top dog on the publishing block? Ranked by their revenues, the quality of the games they release, developer ratings, and other factors pertinent to serious professionals, our annual Top 20 list calls attention to the definitive movers and shakers in the publishing world. 11 By Tristan Donovan 21 INTERVIEW: A PIRATE’S LIFE What do pirates, cowboys, and massively multiplayer online games have in common? They all have Daniel James on their side. CEO of Three Rings, James’ mission has been to create an addictive MMO (or two) that has the pick-up-put- down rhythm of a casual game. In this interview, James discusses the barriers to distributing and charging for such 21 games, the beauty of the web, and the trouble with executables.