Complexin-1 Is a Biomarker of Synucleinopathy
DMM Advance Online Articles. Posted 20 January 2017 as doi: 10.1242/dmm.028035 Access the most recent version at http://dmm.biologists.org/lookup/doi/10.1242/dmm.028035 BLOOD RNA BIOMARKERS IN PRODROMAL PARK4 AND REM SLEEP BEHAVIOR DISORDER SHOW ROLE OF COMPLEXIN-1 LOSS FOR RISK OF PARKINSON’S DISEASE Suna Lahut1,2, Suzana Gispert1, Özgür Ömür1,2, Candan Depboylu3, Kay Seidel4, Jorge Antolio Domínguez-Bautista1, Nadine Brehm1, Hülya Tireli5, Karl Hackmann6, Caroline Pirkevi2, Barbara Leube7, Vincent Ries3, Kerstin Reim8, Nils Brose8, Wilfred F. den Dunnen9, Madrid Johnson10, Zsuzsanna Wolf11, Marc Schindewolf12, Wiebke Schrempf13, Kathrin Reetz14, Peter Young15, David Vadasz3, Achilleas S. Frangakis10, Evelin Schröck6, Helmuth Steinmetz1, Marina Jendrach1, Udo Rüb4, Ayşe Nazlı Başak2¶, Wolfgang Oertel3¶, Georg Auburger1¶ 1Exp. Neurology, Goethe University Medical School, 60590 Frankfurt/Main, Germany; 2NDAL, Boğaziçi University, 34342 Istanbul, Turkey; 3Dept. of Neurology, Philipps University, Baldingerstrasse, 35043 Marburg, Germany; 4Dr. Senckenberg Chronomedical Institute, Goethe University, 60590 Frankfurt/Main, Germany; 5Dept. of Neurology, Haydarpaşa Numune Training and Research Hospital, 34668 Istanbul, Turkey; 6Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany; 7Institute of Human Genetics, Heinrich Heine University, 40225 Düsseldorf, Germany; 8Dept. of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany; 9Dept. of Pathology and Medical Biology, Medical Center, University, 9700 RB Groningen, Netherlands; 10Institut für Biophysik and Frankfurt Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt/Main, Germany; 11Hemophilia Centre, Medical Clinic III, Institute of Transfusion Medicine and Immunhematology Goethe University, 60590 Frankfurt/Main, Germany; 12Dept.
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