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Icsb2006program.Pdf ICSB-2006 The 7th International Conference on Systems Biology October 8 - 13, 2006 Pacifico Yokohama, Yokohama, Japan CONTENTS Welcome to ICSB-2006 ..............................................................................2 Committees ..............................................................................................3 Program Day 1 (October 9) .................................................................4 Day 2 (October 10) ................................................................5 Day 3 (October 11) ................................................................6 Program At-A-Glance .................................................................................9 Student Session (October 10) ..................................................................10 Session Abstracts Plenary Talk Abstracts .........................................................................11 I Systems Biology for Medicine .......................................................13 II Systems Biology of Basic Biological Systems ...............................19 III Fronts in Systems Biology .............................................................27 Poster Session .........................................................................................34 Tutorial Program (October 8) ...................................................................48 Workshops (October 7,12,13) .................................................................49 Access ............................................................................................50 Floor Plan ............................................................................................51 1 Welcome to ICSB-2006 Welcome to the Seventh International Conference on Systems Biology! The International Conference on Systems Biology (ICSB) started in 2000 in Tokyo, and traveled around the world—Pasadena, Stockholm, St. Louis, Heidelberg, and Boston. Owing to the efforts of organizers, sponsors, and participants, the conference has grown into the main conference in the field. This year, ICSB employed parallel sessions for the first time, and invited over 65 distinguished speakers in the field reflecting the overall landscape of systems biology today. With about 400 posters, 12 tutorial sessions, and 5 workshop programs, ICSB-2006 presents the most comprehensive program to date. The program was enabled by generous support from several government agencies and sponsor companies for which we, as the systems biology community, are very grateful. When the first ICSB was held in 2000 at Tokyo with the support of Japan Science and Technology Corporation (JST), systems biology was yet to be recognized as a serious area of study. Nevertheless, it attracted over 300 attendees, over a half of them from outside of Japan. That year featured Prof. Sydney Brenner, a Nobel Laureate in physiology or medicine in 2002, as a banquet speaker. Systems biology is now gaining serious attention world-wide and a number of major research programs and centers have been created. It is my great pleasure that ICSB has grown into the main forum of scientific discussions in systems biology, and has contributed to the field’s progress. However, we should remind ourselves that the field is still in its infancy and much more needs to be done in all areas of research to bring still more maturity to the field. Given the long history of pioneering research leading to the modern form of systems biology, the field may have finally arrived to the point of experiencing a steep learning curve. A scientific problem, experimental techniques, computational analysis, and theoretical frameworks all have to be aligned to address significant questions in biology and decipher their system-level properties and principles. You will witness the growth and future of systems biology at ICSB-2006. Please enjoy the conference and beautiful Japan! Sincerely yours, Hiroaki Kitano Conference Chair, The Seventh International Conference on Systems Biology 2 Committees *alphabetical order by region Program Committee North America: Asia: Adam Arkin (Lawrence Berkeley National Lab., USA) Uri Alon (Weitzman Institute of Science, Israel) Frederick Cross (Rockefeller Univ., USA) Upi Bhalla (National Centre for Biological Science, India) Marie Csete (Emory Univ. USA) Kwang-Hyun Cho (Seoul National Univ., Korea) Francis Doyle (UCSB, USA) Hsuan-Cheng Huang (National Yang-Ming University, John Doyle (Caltech, USA) Taiwan) Joe Gray (Lawrence Berkeley National Lab. USA) Akira Funahashi (SBI & JST ERATO-SORST Kitano Mike Hucka (Caltech, USA) Project, Japan) Trey Ideker (UCSD, USA) Mariko Hatakeyama (RIKEN GSC, Japan) Boris Kholodenko (Thomas Jefferson Univ., USA ) Yoshihide Hayashizaki (RIKEN GSC, Japan) Douglas Lauffenburger (MIT, USA) Do Han Kim (Gwangju Institute of Science and Technology, Pedro Mendes (Virginia Tech., USA) Korea) Bernhard Palsson (UCSD, USA) Hiroaki Kitano (SBI & Sony CSL, Japan) Conference John Tyson (Virginia Tech., USA) Chair Marc Vidal (Dana-Farber Cancer Institute, USA) Shinya Kuroda (Univ. of Tokyo, Japan) Tau-Mu Yi (UCI, USA) Sang Yup Lee (Korea Advanced Institute of Science and Technology, Korea) Student Session Organizer: Edison Liu (Genome Institute of Singapore, Singapore) Satya Arjunan (Keio Univ., Japan) Douglas Murray (SBI & JST ERATO-SORST Kitano John Cumbers (Brown Univ., USA) Project, Japan) Shuichi Onami (Keio Univ., Japan) Advisory Committee Reiko Tanaka (RIKEN BioMimetic Center, Japan) Sydney Brenner (Founding President, Okinawa Institute of Masaru Tomita (Keio Univ., Japan) Science and Technology & The Salk Institute) Hiroki Ueda (RIKEN CDB, Japan) Kiyoshi Kurokawa (President, The Science Council of Japan) Europe: Koichi Kitazawa (Senior Executive-Director, Japan Lilla Alberghina (Univ. of Milano-Bicocca, Italy) Science and Technology Agency) Marta Cascante (Univ. of Barcelona, Spain) Yoshiyuki Sakaki (Director, RIKEN GSC) Roland Eils (DFKI (=German Cancer Research Center), Sin-ichi Nishikawa (Deputy Director, Laboratory for Germany) Stem Cell Biology, Center for Developmental Biology, Peter Ghazal (GTI (=Scottish Centre for Genomic RIKEN) Technology and Informatics), UK) Yoshiki Hotta (President, Research Organization of Igor Goryanin (Univ. of Edinburgh, UK) Information and Systems) Stefan Hohmann (Goteborg Univ., Sweden) Shigetada Nakanishi (Director, Osaka Bioscience Institute) Douglas Kell (Univ. of Manchester, UK) Edda Klipp (Max-Planck Institute for Molecular Genetics, Executive Committee Germany) Kazuyuki Aihara (Univ. of Tokyo and JST ERATO Aihara Pierre De Meyts (Hagedorn Research Institute, Denmark Project) and Novo Nordisk A/S) Akiyasu Fujii (SBI) Jens Nielsen (DTU (=Technical Univ. of Denmark), Denmark) Ken Fukuda (AIST) Staffan Normark (Karolinska Institute, Sweden) Akira Funahashi (SBI & JST ERATO-SORST Kitano Nicolas Le Novere (EBI (=European Bioinformatics Project) Institute), UK) Mariko Hatakeyama (RIKEN GSC) Klaus Prank (GlaxoSmithKline) Hiroaki Kitano (SBI & Sony CSL) Hans Westerhoff (Univ. of Amsterdam, the Netherlands) Tatsuhiko Kodama (Univ. of Tokyo) Shinya Kuroda (Univ. of Tokyo) Yukiko Matsuoka (SBI & JST ERATO-SORST Kitano Project) Satoru Miyano (Univ. of Tokyo) Masahiko Noda (Japan Science and Technology Agency) Makoto Suematsu (Keio Univ. School of Medicine) Hiroki Ueda (RIKEN CDB) Toru Yao (RIKEN GSC) 3 Program Day 1: Monday, October 9, 2006 9:30 Opening 1F Main Hall Speaker Hiroaki Kitano, The Systems Biology Institute, Sony Computer Science Laboratories, Inc. 10:00 P1 Plenary Session 1 1F Main Hall Electricity meets Chemistry: Fast and Slow Signaling in Memory Upinder S. Bhalla, National Centre of Biological Sciences 10:30 P2 Plenary Session 2 1F Main Hall Spatio-temporal Patterns of Intracellular Signaling Atsushi Miyawaki, RIKEN Brain Science Institute 11:00 Break 11:30 P3 Plenary Session 3 1F Main Hall Biological Large Scale Integration Stephen R. Quake, Stanford University / HHMI 12:00 P4 Plenary Session 4 1F Main Hall Evolvability and hierarchy in rewired bacterial gene networks Luis Serrano, European Molecular Biology Laboratory 12:30 Lunch Session Talks 14:00 S1a Systems Biology for Drug Discovery 1F Main Hall Chairs John Morser, Nihon Schering Research Center Osamu Sato, Dai-ichi Pharmaceuticals Speakers From Molecular Events to Clinical Outcome: Computational Systems Biology in the Pharmaceutical Industry Klaus Prank, GlaxoSmithKline Harnessing Systems Biology Using Chemical Synergies Joseph Lehár, CombinatoRX, Inc. Application of Systems Biology for Pharmaceutical Drug Development Jeff Trimmer, Entelos Inc. Systems Biology in Drug Discovery and Development: Impact and Challenges Didier Scherrer, AstraZeneca Technological breakthrough for cell-based target discovery Masato Miyake, CytoPathfinder Inc. 14:00 S1b Cyclic and Dynamic Behaviours 5F Sub Hall 1 Chairs Hiroki Ueda, RIKEN Center for Developmental Biology Lilia Alberghina, University of Milano-Bicocca Speakers A Generic Model of Cell Cycle Regulation in Eukaryotes John J. Tyson, Virginia Tech Probing structure and dynamics of cell cycle in budding yeast Lilia Alberghina, University of Milano-Bicocca Circadian Systems of Cyanobacheria Takao Kondo, Nagoya University Analysis and Synthesis of Mammalian Circadian Clocks Hiroki Ueda, RIKEN Center for Developmental Biology Multi-loop Architecture in Clock Circuits Andrew J. Millar, University of Edinburgh 16:30 - Poster Session I 4F 18:00 18:00 Welcome Reception 5F 4 Day 2: Tuesday, October 10, 2006 9:30 P5 Plenary Session 5 1F Main Hall Dealing with the complexity
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