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PETER WALTER Ph.D. Howard Hughes Medical Institute Department of Biochemistry & Biophysics University of California, San Francisco N312 Genentech Hall, Box 2200 600 16th Street San Francisco CA 94158-2517 415.476.5017; fax 415.476.5233 [email protected] walterlab.ucsf.edu EDUCATION 1973 Abitur Goethe Oberschule (Gymnasium), Berlin-Lichterfelde 1976 Vordiplom Chemistry, Freie Universität Berlin 1977 M.Sc. Organic Chemistry, Vanderbilt University, Nashville, TN 1981 Ph.D. Cell Biology, The Rockefeller University, New York, NY RESEARCH EXPERIENCE 1976-1977 Direct Exchange Fellow, Vanderbilt University, Laboratory of Dr. T.M. Harris 1977-1981 Graduate Fellow, The Rockefeller University, Laboratory of Dr. G. Blobel 1981-1982 Postdoctoral Fellow, The Rockefeller University, Laboratory of Dr. G. Blobel 1982-1983 Assistant Professor, Laboratory of Cell Biology, The Rockefeller University 1983-1986 Assistant Professor, Department of Biochemistry & Biophysics, University of California, San Francisco (UCSF) 1986-1991 Associate Professor, Department of Biochemistry & Biophysics, UCSF 1991- present Professor, Department of Biochemistry & Biophysics, UCSF 1997-present Investigator, Howard Hughes Medical Institute 2001-2008 Chair, Department of Biochemistry & Biophysics Department, UCSF HONORS & AWARDS 1983 Searle Scholar Award 1988 Eli Lilly Award for Fundamental Research in Biological Chemistry 1988 Passano Award 1989 Alfred P. Sloan Award 1993 NIH MERIT Award 1996 Harvey Lecturer, Rockefeller University, New York 1998 American Academy of Microbiology (elected Fellow) 1998 Feodor-Lynen-Lecture, Mosbach Kolloquium, Germany 2001 American Academy of Arts & Sciences (elected Fellow) 2004 National Academy of Sciences (elected Member) 2004 European Molecular Biology Organization (elected Associate Member) 2004 Virchow Medal and Lecture, Universität Würzburg 2005 Wiley Prize in Biomedical Sciences (with Kazutoshi Mori) 2006 George E. Palade Distinguished Lecture, Wayne State University School of Medicine 2006 47th Stadtler Lecture, University of Texas 2006 Leopoldina Academy of Scientists (elected member) 2007 50th Faculty Research Lecturer, University of California, San Francisco 2009 Stein and Moore Award, The Protein Society 2009 Gairdner International Award (with Kazutoshi Mori) 2009 E.B. Wilson Award, American Society for Cell Biology 2010 Chilton Lecturer, University of Texas 2011 Chiron Lecturer, University of California, Berkeley 2011 Otto Warburg Medal, The German Society for Biochemistry and Molecular Biology 2011 Glenn Award for Research in Biological Mechanisms of Aging 2012 Ernst Jung Prize for Medicine (with Eliza Izauralde) 2012 Paul Ehrlich and Ludwig Darmstaedter Prize Updated Sept 11, 2015 2012 Detlev Bronk Alumni Lecturer, Rockefeller University 2013 George E. Palade Memorial Lecturer, Yale University 2013 Mendel Lecturer, Brno, Czech Republic 2014 Shaw Prize (with Kazutoshi Mori) 2014 Lasker Award for Basic Medical Research (with Kazutoshi Mori) 2015 Vilcek Prize in Biomedical Science 2015 Vallee Visiting Professorship 2015 Auswärtiges Wissenschaftliches Mitglied at the Max-Planck-Instituts für Biophysics PROFESSIONAL ACTIVITIES NIH Study Section on Molecular Cytology 1992: ad hoc member, 2 sessions; 1993-1997: full member 1998 NIH Intramural Review Committee, 2002-2004 ASCB Council (elected Counselor) 2003 NAS and IOM Committee to consider potential routes to the development of antiviral drugs against variola and other poxviruses 2014-2016 ERC Consolidator Grant (CoG) LS3 Panel - Cellular and Developmental Biology - 2015 Auswärtiges Wissenschaftliches Mitglied at the Max-Planck-Instituts für Biophysics 2016 ASCB President-Elect Meetings Organized 1989 Gordon Conference: Molecular Membrane Biology (Vice Chair) 1991 Gordon Conference: Molecular Membrane Biology (Chair) 1991 ASCB Annual Meeting (Program Chair) 1999 Gordon Conference for Molecular Cell Biology (Vice Chair) 2001 Gordon Conference for Molecular Cell Biology (Chair) 2005 Gordon Conference on Stress Proteins in Growth, Development & Disease (Vice Chair) 2007 Gordon Conference on Stress Proteins in Growth, Development and Disease (Chair) 2016 Scientific Advisory Boards 2002-2007 MPI für Biochemie Martinsried 2002-2007 Institut für Genetik, Universität zu Köln 2003-2008 MPI für Biophysikalische Chemie, Göttingen 2006-present Zentrum für Molekulare Biologie der Universität Heidelberg UCSF – Selected Administrative Service 1995-1999 Director, UCSF Cell Biology Program 1995-1999 Vice Chair, Department of Biochemistry & Biophysics 1995-present Graduate Adviser, Programs in Biological Sciences (Biochemistry & Molecular Biology, Cell Biology, Developmental Biology, and Genetics) 1995-1997 Co-Director, Science & Health Education Partnership (SEP) Principal Investigator, City Science NSF Grant 1997-present Science and Health Education Partnership Faculty Advisory Committee 1998-present UCSF Mission Bay Campus Site Planning & Design Committee 2001-2008 Chair, Department of Biochemistry & Biophysics Department 2001-present UC Institute for Bioengineering, Biotechnology & Quantitative Biomedical Research (QB3) 2003-2008 Chair, UCSF Mission Bay Campus-Genentech Hall Governance Committee Editorial Boards 1987 - 1996 Molecular and Cellular Biology, member 1992 - 1995 Protein Science, member 1994 - 2000 Biological Chemistry, member Updated Sept 11, 2015 1994 - 2002 Current Biology, member 1992 - 2009 Molecular Biology of the Cell (Associate Editor, 1996- ) 1999 - 2009 Genome Biology, Advisory Board member 2001 - present Faculty 1000 (Section Head) 2003 - present Public Library of Science (PLOS), Biology, Editorial Board Member 2004 - 2009 Proceedings of the National Academy of Sciences, Editorial Board Member 2008 - present BMC Biology (formerly Journal of Biology) PUBLICATIONS JOURNALS ARTICLES 1. Walter P & Harris TM. (1978) Annelation of ethyl propiolate with ethyl pipecolate. J. Org. Chem. 43, 4250-4252. 2. Clevestine EC, Walter P, Harris TM, & Broquist HP. (1979) Biosynthesis of slaframine, (1S,6S,8aS)-l-Acetoxy-6-aminoctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. 4. Metabolic fate of ethyl pipecolylacetate, 1,3-Dioxooctahydroindolizine, and l- Hydroxyoctahydroindolizine in Rhizoctonia leguminicola. Biochemistry 18, 3663-3667. 3. Walter P, Jackson RC, Marcus MM, Lingappa VR, & Blobel G. (1979) Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc. Nat. Acad. Sci. USA 76, 1795-1799. PMCID: PMC383478 4. Jackson RC, Walter P, & Blobel G. (1980) Secretion requires a cytoplasmically disposed sulfhydryl of the RER membrane. Nature 286, 174-176. 5. Walter P & Blobel G. (1980) Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci USA 77, 7112-7116. PMCID: PMC350451 6. Walter P, Ibrahimi I, & Blobel G. (1981) Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol 91, 545-550. 7. Walter P & Blobel G. (1981) Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro- assembled polysomes synthesizing secretory protein. J Cell Biol 91, 551-556. 8. Walter P & Blobel G. (1981) Translocation of proteins across the endoplasmic reticulum. III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol 91, 557-561. 9. Stoffel W, Blobel G, & Walter P. (1981) Synthesis in vitro and translocation of apolipoprotein AI across microsomal vesicles. Eur J Biochem 120, 519-522. 10. Anderson DJ, Walter P, & Blobel G. (1982) Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane. J Cell Biol 93, 501-506. 11. Müller M, Ibrahimi I, Chang CN, Walter P, & Blobel G. (1982) A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum. J Biol Chem 257, 11860-11863. 12. Gilmore R, Blobel G, & Walter P. (1982) Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol 95, 463-469. 13. Gilmore R, Walter P, & Blobel G. (1982) Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol 95, 470- 477. 14. Walter P & Blobel G. (1982) Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature 299, 691-698. 15. Erickson AH, Walter P & Blobel G. (1983) Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle. Biochem Biophys Res Commun 115, 275-280. 16. Walter P & Blobel G. (1983) Disassembly and reconstitution of signal recognition particle. Cell 34, 525-533. Updated Sept 11, 2015 17. Walter P & Blobel G. (1983) Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe. J Cell Biol 97, 1693-1699. 18. Bonatti S, Migliaccio G, Blobel G, & Walter P. (1984) Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins.
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