Derwent World Patents Index
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Author Index Volumes 201–244
Author Index Volumes 201–244 Author Index Vols. 26–50 see Vol. 50 Author Index Vols. 51–100 see Vol. 100 Author Index Vols. 101–150 see Vol. 150 Author Index Vols. 151–200 see Vol. 200 The volume numbers are printed in italics Achilefu S, Dorshow RB (2002) Dynamic and Continuous Monitoring of Renal and Hepatic Functions with Exogenous Markers. 222: 31–72 Albert M, see Dax K (2001) 215: 193–275 Albrecht M (2005) Supramolecular Templating in the Formation of Helicates. 248: 105–139 Ando T, Inomata S-I, Yamamoto M (2004) Lepidopteran Sex Pheromones. 239: 51–96 Angyal SJ (2001) The Lobry de Bruyn-Alberda van Ekenstein Transformation and Related Reactions. 215: 1–14 Antzutkin ON, see Ivanov AV (2005) 246: 271–337 Anupõld T, see Samoson A (2005) 246: 15–31 Armentrout PB (2003) Threshold Collision-Induced Dissociations for the Determination of Accurate Gas-Phase Binding Energies and Reaction Barriers. 225: 227–256 Astruc D, Blais J-C, Cloutet E, Djakovitch L, Rigaut S, Ruiz J, Sartor V,Valério C (2000) The First Organometallic Dendrimers: Design and Redox Functions. 210: 229–259 Augé J, see Lubineau A (1999) 206: 1–39 Baars MWPL, Meijer EW (2000) Host-Guest Chemistry of Dendritic Molecules. 210: 131– 182 Balazs G, Johnson BP, Scheer M (2003) Complexes with a Metal-Phosphorus Triple Bond. 232: 1–23 Balbo Block MA, Kaiser C, Khan A, Hecht S (2005) Discrete Organic Nanotubes Based on a Combination of Covalent and Non-Covalent Approaches. 245: 89–150 Balczewski P,see Mikoloajczyk M (2003) 223: 161–214 Ballauff M (2001) Structure of Dendrimers in Dilute Solution. -
Rodd's Chemistry of Carbon Compound S
RODD'S CHEMISTRY OF CARBON COMPOUND S A modern comprehensive treatis e SECOND EDITIO N Edited by S . COFFE Y M.Sc. (London), D.Sc. (Leyden), F .R.I.C. formerly of I.C.I. Dyestuffs Division, Blackley, Manchester VOLUME II PART C POLYCARBOCYCLIC COMPOUNDS , EXCLUDING STEROIDS PREFACE VII OFFICIAL PUBLICATIONS ; SCIENTIFIC JOURNALS AND PERIODICALS X V LIST OF COMMON ABBREVIATIONS AND SYMBOLS USED XV I Chapter 9. Polycarbocyclic Compounds with Separate Ring Systems , and Spiro Compounds N. A . J . RoGERs 1. General introduction to polycarbocyclic compounds ; classification and nomenclature a. Classification I b. Nomenclature 2 (i) Ring-systems joined directly or through a carbon chain, 3 - (ii) Spir o compounds, 3 - (iii) Fused and bridged ring-systems, 4 2 . Compounds with rings joined directly or through a carbon chain 5 a. General methods of synthesis 6 b. Polycyclopropyl compounds 6 c. Polycyclobutyl compounds 9 d. Polycyclopentyl compounds 9 e. Cyclopropylcyclopentane compounds 1 3 f. Cyclopropylcyclohexane compounds 1 3 g. Cyclobutylcyclohexane compounds 13 h. Cyclopentylcyclohexane compounds 14 i. Polycyclohexyl compounds 1 4 (i) Hydrocarbons, r4 - (ii) Hydroxy and amino derivatives, 15 - (iii) Ketones, 16 - (iv) Carboxylic acids, I q j. Cyclopentylcycloheptane compounds 1 7 k. Cyclohexylcycloheptane compounds 1 8 1. Bicycloheptyl and its derivatives 1 8 m . Bicyclo-octyl and related compounds 1 8 3. Spiro compounds ; spiranes 20 a. The spiro[z .z]pentane group 2 1 b. The spiro[2 .3]hexane group 22 c. The spiro[z .4]heptane group 23 d. The spiro[2 .5]octane group 24 e. The spiro[2,6]nonane group 2 5 f. -
Gastroprotective Effect of Tabernaemontana Divaricata (Linn.) R.Br
British Journal of Pharmaceutical Research 1(3): 88-98, 2011 SCIENCEDOMAIN international www.sciencedomain.org Gastroprotective Effect of Tabernaemontana divaricata (Linn.) R.Br. Flower Methanolic Extract in Wistar Rats Mohammed Safwan Ali Khan1,2&3* 1Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia. 2Department of Pharmacognosy, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad 500001, Andhra Pradesh, India. 3Department of Pharmaceutical Sciences, Nims University, Shobha Nagar, Delhi Highway, Jaipur - 303 121, Rajasthan, India. Received 24th April 2011 Accepted 2nd June 2011 Research Article Online Ready 6th June 2011 ABSTRACT Tabernaemontana divaricata (L.) R.Br belonging to Apocynaceae family is traditionally used by people in many parts of the world to treat various disorders. The present study was undertaken to investigate anti-ulcer property of Tabernaemontana divaricata flower methanolic extract (TDFME 500 mg/kg, p.o) by pyloric ligation induced gastric ulceration model using Omeprazole (8mg/kg, p.o) as a standard drug in wistar rats. Five parameters i.e., volume of gastric juice, pH, free & total acidities and ulcer index were assessed. The test extract significantly (p< 0.01) decreased volume of gastric juice, free & total acidities and ulcer index. Like standard, it also raised pH of gastric acid. The observed percentage protection for standard and test were 89.84% and 79.53%, respectively. Thus, TDFME 500 mg/kg had a positive effect on all the parameters under study and the results were similar to that of standard. From the above results, it can be concluded that TDFME exhibits remarkable gastroprotective effect. -
Thiazoline-Specific Amidohydrolase Purah Is the Gatekeeper of Bottromycin Biosynthesis
\ Sikandar, A., Franz, L., Melse, O., Antes, I. and Koehnke, J. (2019) Thiazoline-specific amidohydrolase PurAH is the gatekeeper of bottromycin biosynthesis. Journal of the American Chemical Society, 141(25), pp. 9748-9752. (doi: 10.1021/jacs.8b12231) The material cannot be used for any other purpose without further permission of the publisher and is for private use only. There may be differences between this version and the published version. You are advised to consult the publisher’s version if you wish to cite from it. http://eprints.gla.ac.uk/224167/ Deposited on 16 November 2020 Enlighten – Research publications by members of the University of Glasgow http://eprints.gla.ac.uk The Thiazoline-Specific Amidohydrolase PurAH is the Gatekeeper of Bottromycin Biosynthesis Asfandyar Sikandar,†,‡ Laura Franz,†,‡ Okke Melse,§ Iris Antes,§ and Jesko Koehnke†,* †Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Cen- tre for Infection Research, Saarland University, Campus Geb. E8.1, 66123 Saarbrücken, Germany §Center for Integrated Protein Science Munich at the TUM School of Life Sciences, Technische Universität München, Emil-Erlen- meyer-Forum 8, 85354 Freising, Germany Supporting Information Placeholder ABSTRACT: The ribosomally synthesized and post-transla- the a/b-hydrolase BotH, successive oxidative decarboxylation of tionally modified peptide (RiPP) bottromycin A2 possesses the thiazoline to a thiazole (BotCYP) and O-methylation of an potent antimicrobial activity. Its biosynthesis involves the en- aspartate (BotOMT) complete bottromycin biosynthesis. zymatic formation of a macroamidine, a process previously Scheme 1. (a) A gene cluster highly homologous in se- suggested to require the concerted efforts of a YcaO enzyme quence and organization to those of confirmed bottromy- (PurCD) and an amidohydrolase (PurAH) in vivo. -
The Iboga Alkaloids
The Iboga Alkaloids Catherine Lavaud and Georges Massiot Contents 1 Introduction ................................................................................. 90 2 Biosynthesis ................................................................................. 92 3 Structural Elucidation and Reactivity ...................................................... 93 4 New Molecules .............................................................................. 97 4.1 Monomers ............................................................................. 99 4.1.1 Ibogamine and Coronaridine Derivatives .................................... 99 4.1.2 3-Alkyl- or 3-Oxo-ibogamine/-coronaridine Derivatives . 102 4.1.3 5- and/or 6-Oxo-ibogamine/-coronaridine Derivatives ...................... 104 4.1.4 Rearranged Ibogamine/Coronaridine Alkaloids .. ........................... 105 4.1.5 Catharanthine and Pseudoeburnamonine Derivatives .. .. .. ... .. ... .. .. ... .. 106 4.1.6 Miscellaneous Representatives and Another Enigma . ..................... 107 4.2 Dimers ................................................................................. 108 4.2.1 Bisindoles with an Ibogamine Moiety ....................................... 110 4.2.2 Bisindoles with a Voacangine (10-Methoxy-coronaridine) Moiety ........ 111 4.2.3 Bisindoles with an Isovoacangine (11-Methoxy-coronaridine) Moiety . 111 4.2.4 Bisindoles with an Iboga-Indolenine or Rearranged Moiety ................ 116 4.2.5 Bisindoles with a Chippiine Moiety ... ..................................... -
Effects of the Putative Antipsychotic Alstonine on Glutamate Uptake in Acute Hippocampal Slices ⇑ Ana P
Neurochemistry International 61 (2012) 1144–1150 Contents lists available at SciVerse ScienceDirect Neurochemistry International journal homepage: www.elsevier.com/locate/nci Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices ⇑ Ana P. Herrmann a,b, , Paula Lunardi b, Luísa Klaus Pilz a, Ana C. Tramontina b, Viviane M. Linck a,b, Christopher O. Okunji c, Carlos A. Gonçalves b, Elaine Elisabetsky a,b a Laboratório de Etnofarmacologia, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brazil b Programa de Pós-graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, 90035-000 Porto Alegre, RS, Brazil c International Centre for Ethnomedicine and Drug Development (InterCEDD), Nsukka, Enugu State, Nigeria article info abstract Article history: A dysfunctional glutamatergic system is thought to be central to the negative symptoms and cognitive Received 8 March 2012 deficits recognized as determinant to the poor quality of life of people with schizophrenia. Modulating Received in revised form 13 August 2012 glutamate uptake has, thus, been suggested as a novel target for antipsychotics. Alstonine is an indole Accepted 15 August 2012 alkaloid sharing with atypical antipsychotics the profile in animal models relevant to schizophrenia, Available online 25 August 2012 though divergent in its mechanism of action. The aim of this study was to evaluate the effects of alstonine on glutamate uptake. Additionally, the effects on glutathione content and extracellular S100B levels were Keywords: assessed. -
Biosynthesis by in Situ Hybridization (ISH)
Localization of monoterpenoid indole alkaloid (MIA) biosynthesis by in situ hybridization (ISH) By Elizabeth Edmunds, Hons. B.Sc. A Thesis Submitted to the Department of Biotechnology In partial fulfillment of the requirements For the degree of Masters of Science August, 2012 Brock University St. Catha rines, Ontario ©Elizabeth Edmunds, 2012 ii Acknowledgments First and foremost I would like to thank Dr. Vincenzo Deluca for the opportunity to work in his laboratory under his mentorship. I have appreciated the helpful insight that has guided me through the course of this project. I have gained a valuable experience being able to learn from such an established and knowledgeable researcher. Secondly, I would like to thank my committee members Dr. Jeffrey Atkinson and Dr. Heather Gordon for their support and advice and their time to serve on my advisory committee. Thirdly, I would like to thank my colleagues and co-workers for their patience and helpful advice throughout my project. Particular mention must be given to Dr. Carlone's lab for their assistance and insight into in situ hybridization techniques. Finally, I would like to express my sincerest gratitude and appreciation towards my family and friends for their support. I would not be where I am today without the support and love from my mother and father, as well as Craig Easton. iii Abstract Monoterpenoid indole alkaloids (MIA) are among the largest and most complex group of nitrogen containing secondary metabolites that are characteristic of the Apocynaceae plant family including the most notable Catharanthus roseus. These compounds have demonstrated activity as successful drugs for treating various cancers, neurological disorders and cardiovascular conditions. -
(12) United States Patent (10) Patent No.: US 9,687,864 B2 Fulton Et Al
USOO9687864B2 (12) United States Patent (10) Patent No.: US 9,687,864 B2 Fulton et al. (45) Date of Patent: Jun. 27, 2017 (54) SYSTEMAND METHOD FOR ENHANCED 428/25 (2015.01); Y10T 428/31504 (2015.04); ELECTROSTATIC DEPOSITION AND Y10T 428/31507 (2015.04); SURFACE COATINGS (Continued) (58) Field of Classification Search (71) Applicant: Battelle Memorial Institute, USPC .......... 118/620–640; 23.9/690 708; 427/458, Columbus, OH (US) 427/475 4.86 (72) Inventors: John L. Fulton, Richland, WA (US); See application file for complete search history. George S. Deverman, Richland, WA (US); Dean W. Matson, Kennewick, (56) References Cited CA (US); Clement R. Yonker, Kennewick, WA (US); C. Douglas U.S. PATENT DOCUMENTS Taylor, Franklinton, NC (US); James 3,087,860 A 4, 1963 Endicott B. McClain, Raleigh, NC (US); Joseph 3,123,077 A 3, 1964 Alcamo M. Crowley, Cambria, CA (US) (Continued) (73) Assignee: Battelle Memorial Institute, Columbus, OH (US) FOREIGN PATENT DOCUMENTS CA 2589761 12, 2004 (*) Notice: Subject to any disclaimer, the term of this CN 1465410 1, 2004 patent is extended or adjusted under 35 (Continued) U.S.C. 154(b) by 0 days. (21) Appl. No.: 14/310,960 OTHER PUBLICATIONS Abreu Filho et al., “Influence of metal alloy and the profile of (22) Filed: Jun. 20, 2014 coronary stents in patients with multi-vessel coronary disease.” Clinics 66(6):985-989 (2011). (65) Prior Publication Data (Continued) US 2015/OO40827 A1 Feb. 12, 2015 Related U.S. Application Data Primary Examiner — Yewebdar Tadesse (74) Attorney, Agent, or Firm — Lerner, David, (62) Division of application No. -
Fused Tricyclic Dual Inhibitors of Cdk 4/6 and Flt3
(19) TZZ ¥¥_T (11) EP 2 937 349 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 28.10.2015 Bulletin 2015/44 C07D 471/14 (2006.01) C07D 519/00 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) (2006.01) (21) Application number: 15161337.9 A61P 35/02 (22) Date of filing: 21.03.2012 (84) Designated Contracting States: • Keegan, Kathleen S. AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Bainbridge Island, WA Washington 98110 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • LI, Zhihong PL PT RO RS SE SI SK SM TR Millbrae, CA California 94030 (US) Designated Extension States: • Lively, Sarah E. BA ME San Carlos, CA California 94070 (US) • McGee, Lawrence R. (30) Priority: 23.03.2011 US 201161466841 P Pacifica, CA California 94044 (US) •Ragains,Mark L. (62) Document number(s) of the earlier application(s) in Fort Worth, TX Texas 76109 (US) accordance with Art. 76 EPC: • Wang, Xianghong 12711738.0 / 2 688 887 Dublin, CA California 94568 (US) • Weidner, Margaret F. (71) Applicant: AMGEN INC. Woodinville, WA Washington 98072 (US) Thousand Oaks, CA 91320-1799 (US) • Zhang, Jian Foster City, CA California 94404 (US) (72) Inventors: • Chen, Xiaoqi (74) Representative: Hoffmann Eitle Palo Alto, CA California 94303 (US) Patent- und Rechtsanwälte PartmbB •Dai,Kang Arabellastraße 30 Albany, CA California 94706 (US) 81925 München (DE) • Duquette, Jason A. Millbrae, CA California 94030 (US) Remarks: • Gribble, Michael W., Jr. This application was filed on 12-05-2015 as a San Francisco, CA California 94110 (US) divisional application to the application mentioned • Huard, Justin N. -
By M. TICHY Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague (Received October 10, 1975)
CHEMISTRY OF TWISTANE SYSTEM AND ITS USE IN STEREOCHEMISTRY* By M. TICHY Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague (Received October 10, 1975) The aim of the present review is to show the chemistry of twistane system and the various ways in which it can be used as a stereochemical model of great utility. Many of the stereochemical appli- cations mentioned are the result of investigations made in the author's Laboratory. Twistane — tricyclo(4,4,0,03,8)decane (I) — belongs to the great family of adamantane isomers** of the formula C10H16. It is composed solely of six-membered rings, twisted in the same sense. The parent hydrocarbon has three two-fold rota- tional axes of symmetry (D2) and exists in two enantiomeric forms which differ in the sense of twist: according to the CAHN—INGOLD—PRELOG nomenclature [11] the enantiomer (la) has P-helicity whereas the other (lb) M-helicity. la lb • * This review is based on a lecture presented at A. Jôzsef University, Szeged, and on the review in Chem. Listy 69, 45 (1975). »* For reviews on adamantane chemistry see [1—3], adamantane isomers other than twistane are studied e.g. in ref. [4—10]. 158 M. TICHY There are three groups of sterically analogous carbon atoms in this system: carbons 1,3,6,8, carbons 4,5,9,10 and carbons 2 and 7. Whereas the two bonds at C(2) and C(7) in the parent hydrocarbon are sterically equivalent, the bonds in positions 4,5,9 and 10 are non-equivalent and therefore substitution in these positions affords two diastereoisomeric (monosubstituted) derivatives (Formulae A and B). -
University Microfilms, Inc., Ann Arbor, Michigan ADRENOCORTICAL STEROID PROFILE IN
This dissertation has been Mic 61-2820 microfilmed exactly as received BESCH, Paige Keith. ADRENOCORTICAL STEROID PROFILE IN THE HYPERTENSIVE DOG. The Ohio State University, Ph.D., 1961 Chemistry, biological University Microfilms, Inc., Ann Arbor, Michigan ADRENOCORTICAL STEROID PROFILE IN THE HYPERTENSIVE DOG DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of the Ohio State University By Paige Keith Besch, B. S., M. S. The Ohio State University 1961 Approved by Katharine A. Brownell Department of Physiology DEDICATION This work is dedicated to my wife, Dr. Norma F. Besch. After having completed her graduate training, she was once again subjected to almost social isolation by the number of hours I spent away from home. It is with sincerest appreciation for her continual encouragement that I dedi cate this to her. ACKNOWLEDGMENTS I wish to acknowledge the assistance and encourage ment of my Professor, Doctor Katharine A. Brownell. Equally important to the development of this project are the experience and information obtained through the association with Doctor Frank A. Hartman, who over the years has, along with Doctor Brownell, devoted his life to the development of many of the techniques used in this study. It is also with extreme sincerity that I wish to ac knowledge the assistance of Mr. David J. Watson. He has never complained when asked to work long hours at night or weekends. Our association has been a fruitful one. I also wish to acknowledge the encouragement of my former Professor, employer and good friend, Doctor Joseph W. -
Arxiv:2105.14305V1 [Cs.CG] 29 May 2021
Efficient Folding Algorithms for Regular Polyhedra ∗ Tonan Kamata1 Akira Kadoguchi2 Takashi Horiyama3 Ryuhei Uehara1 1 School of Information Science, Japan Advanced Institute of Science and Technology (JAIST), Ishikawa, Japan fkamata,[email protected] 2 Intelligent Vision & Image Systems (IVIS), Tokyo, Japan [email protected] 3 Faculty of Information Science and Technology, Hokkaido University, Hokkaido, Japan [email protected] Abstract We investigate the folding problem that asks if a polygon P can be folded to a polyhedron Q for given P and Q. Recently, an efficient algorithm for this problem has been developed when Q is a box. We extend this idea to regular polyhedra, also known as Platonic solids. The basic idea of our algorithms is common, which is called stamping. However, the computational complexities of them are different depending on their geometric properties. We developed four algorithms for the problem as follows. (1) An algorithm for a regular tetrahedron, which can be extended to a tetramonohedron. (2) An algorithm for a regular hexahedron (or a cube), which is much efficient than the previously known one. (3) An algorithm for a general deltahedron, which contains the cases that Q is a regular octahedron or a regular icosahedron. (4) An algorithm for a regular dodecahedron. Combining these algorithms, we can conclude that the folding problem can be solved pseudo-polynomial time when Q is a regular polyhedron and other related solid. Keywords: Computational origami folding problem pseudo-polynomial time algorithm regular poly- hedron (Platonic solids) stamping 1 Introduction In 1525, the German painter Albrecht D¨urerpublished his masterwork on geometry [5], whose title translates as \On Teaching Measurement with a Compass and Straightedge for lines, planes, and whole bodies." In the book, he presented each polyhedron by drawing a net, which is an unfolding of the surface of the polyhedron to a planar layout without overlapping by cutting along its edges.