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13Th - 14Th September 2017 Sandown Park Racecourse, Esher, Surrey 13th - 14th September 2017 Sandown Park Racecourse, Esher, Surrey Abstracts 1 These papers are published with permission of the authors who have granted IPEM a non– exclusive right to publish, reproduce, distribute, display and store the abstract worldwide in all forms (including on the Institute’s website), formats and media now known or as developed in the future, including print, electronic and digital forms. Full copyright of the abstracts remains with the author. Copyright of this publication remains with IPEM. Institute of Physics & Engineering in Medicine Fairmount House 230 Tadcaster Road York YO24 1ES ISBN 978-1-903613-64-1 2 CONTENTS Wednesday 13th September 2017 ............................................................................ 4 Plenary Session – Woolmer Lecture ....................................................................................................... 4 EFOMP Session ..................................................................................................................................... 5 Clinical Measurement ........................................................................................................................... 9 Cardiovascular Computational Modelling I ........................................................................................... 14 Student/Associate/Trainee I ................................................................................................................ 19 Clinical Imaging ................................................................................................................................... 22 Plenary Session ................................................................................................................................... 27 Influencing decision makers: a researcher’s guide ................................................................................ 28 Pre Clinical Imaging ............................................................................................................................. 29 Cardiovascular Computational Modelling II .......................................................................................... 32 Student/Associate/Trainee II ............................................................................................................... 37 Image Guided Therapy ........................................................................................................................ 41 Making the leap: becoming a medical engineering entrepreneur .......................................................... 44 Musculoskeletal Biomechanics ............................................................................................................ 45 Cells and biocompatible materials ....................................................................................................... 52 Student/Associate/Trainee III .............................................................................................................. 58 Radiotherapy Imaging ......................................................................................................................... 65 Thursday 14th September 2017 .............................................................................. 72 Statistics Teaching Session .................................................................................................................. 72 Plenary session: IOP MPG sponsored lecture ....................................................................................... 72 Radiotherapy Advances ....................................................................................................................... 73 Virtual Reality Workshop .................................................................................................................... 79 Ultrasound Workshop ......................................................................................................................... 79 Author Workshop ............................................................................................................................... 79 Research culture: visions of 2035 ......................................................................................................... 80 Diagnostic Radiology ........................................................................................................................... 81 Industry session: Future Innovations in Imaging and Radiotherapy ....................................................... 86 Cardiovascular Engineering ................................................................................................................. 88 Medical Robotics ................................................................................................................................ 93 Radiotherapy Dosimetry I.................................................................................................................... 97 Innovative and Sustainable Healthcare Technology ............................................................................ 100 Engineering Design............................................................................................................................ 103 Radiotherapy Dosimetry II ................................................................................................................. 106 Professional Session .......................................................................................................................... 110 Clinical Engineering ........................................................................................................................... 113 Magnetic Resonance ......................................................................................................................... 118 POSTERS ............................................................................................................... 124 INDEX OF PRESENTING AUTHORS ......................................................................... 160 3 Wednesday 13th September 2017 Wednesday 13th September 2017, 09.45 – 10.30 Plenary Session – Woolmer Lecture Why do rigid tumours contain soft cancer cells? Franziska Wetzel1,, Anatol W. Fritsch1,, Dapeng Bi7, Roland Stange1, Steve Pawlizak1, Tobias R. Kießling1, Mareike Zink1, Lars-Christian Horn3, Klaus Bendrat4,9, Maja Oktay5, Axel Niendorf4, John Condeelis6, Michael Höckel2, M. Cristina Marchetti8, M. Lisa Manning8, Josef A. Käs1 1Soft Matter Physics Division, Leipzig University, 04103 Leipzig, Germany. 2Department of Obstetrics and Gynecology, Women's and Children's Center, Leipzig University, 04103Leipzig, Germany. 3Division of Breast, Urogenital and Perinatal Pathology, Institute of Pathology, Leipzig University, Germany. 4Pathology Hamburg-West, 22767 Hamburg, Germany. 5Montefiore Medical Center, Bronx, NY 10467, USA. 6Albert Einstein College of Medicine, Bronx, NY 10461, USA. 7Center for Studies in Physics and Biology, Rockefeller University, USA. 8Department of Physics, Syracuse University, USA. 9Institute for Biochemistry and Molecular Cell Biology, University Hospital Hamburg- Eppendorf, Martinstrasse 52, 20246 Hamburg, Germany. As early as 50 AD, the Roman medical encyclopaedist Celsus recognized that solid tumours are stiffer than surrounding tissue. However, cancer cell lines are softer, which facilitates invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment, or are soft cells already present inside a primary tumour? If the latter, how can cancer tissue be more rigid than normal tissue and yet contain more soft cells? Here we show that in primary samples from patients with mammary and cervical carcinomas, cells do exhibit a broad distribution of rigidities, with a higher fraction of softer and more contractile cells compared to normal tissue. Mechanical modelling based on patient data reveals that tumours with a significant fraction of very soft cells can still remain solid. Moreover, in tissues with the observed distributions of cell stiffness, softer cells spontaneously self-organize into multicellular streams, possibly facilitating cancer metastasis. 4 Wednesday 13th September 2017, 11.00 – 12.00 EFOMP Session European Examination Board – report on the first initiative 1,2John Damilakis 1EFOMP President, EEB Chair 2Department of Medical Physics, University of Crete, Greece EFOMP’s Examination Board (EEB) has been established to facilitate the harmonization of Medical Physics education and training standards throughout Europe. EEB introduces the European Diploma of Medical Physics (EDMP) and the European Attestation Certificate to those Medical Physicists that have reached the Medical Physics Expert level (EACMPE). EEB examinations are tests of excellence in Medical Physics. They are designed to assess the knowledge, skills and competences requisite for the delivery of high standard Medical Physics services. Currently medical physicists in European countries face difficulties in providing the necessary qualification evidence when they seek employment in other EU Member States or other countries. The EDMP will facilitate mobility of medical physicists in Europe and beyond. Furthermore, EEB provides an attestation certificate to those medical physicists that have reached the Medical Physics Expert level to be recognized by the relevant competent authorities of the EU according to the EU Directive 2013/59/EURATOM laying down
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