2020 ANNUAL REPORT

MEETING THE Moment Dedicated. Resourceful. Resilient. Read herperspective onpage54. Initiatives, isaleaderdrivingforward change to make MSKamore inclusive place for all. Yaihara Fortis Santiago, Associate Director, Office of Postdoctoral Affairs & Trainee Diversity

1 Annual Report 2020 2 The SocietyofMemorialSloanKettering Financial Summary Statistical Profile Leadership Boards ofTrusteesandGoverning Donors toMemorialSloanKettering MSK Giving diversity, equality,andinclusion Meet someofthepeoplecommittedtoMSK's Moments forChange scientific breakthroughsoftheyear Read aboutsomeofthebiggest Moments ofDiscovery during theCOVID-19pandemic See howtheMSKcommunityperseveredtofulfillourmission Moments ofStrength Message fromtheChairmanandPresident to makingadvances intargeted therapies. Read about theirlife-changing work onpage38. Alexander Drilon,Chief oftheEarlyDrugDevelopment Service (left),leadsagroup of experts dedicated Contents ...... TABLE OF ......

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LETTER 6 and closerto ourpatients’ homesandwork, to make itless stressful, withfewer sideeffects, our decades-longeffort to transform cancer care programs. This center isthelatest milestone in Thoracic Oncology, andHeadNeckCancer and isnow hometo ourHematologic Malignancy, our pioneeringnetwork ofoutpatient facilities up for fullpatient care. This 26-story center joins Memorial SloanKettering Cancer Center opened when theDavid H.Koch Center for Cancer Care at an outpatient basis took anothermajorstep Helping More People, InMore Ways cancer, inevery way we can. to oursingularmission to helpingpeoplewith year. Andwe lookforward withgreat optimism has accomplished duringadeeplychallenging We are proud of what theentire MSKcommunity thanks to thetireless dedication ofourstaff. nearly backto pre-pandemic levels at MSK, disproportionately by communities ofcolor. at reducing thecancer burden that isborne that MSKismore inclusive andmore effective want to share importantprogress inensuring for cancer care duringthepandemic.We also fighting COVID-19 that helpedsetthe standard over thepast year, includingcontributions to We are proud to report thestrides MSKhasmade the understanding andtreatment ofcancer. commitment to care for themwithcompassion andto advance during theCOVID-19 pandemic.Just asunwavering was MSK’s Their fierce determination to regain theirhealthnever dimmed Memorial SloanKettering. For more than135 years, peoplefacing cancer have counted on THE CHAIRMANANDPRESIDENT A MESSAGE FROM In early2020, ourabilityto care for peopleon Today, patient activityandresearch are

people were undergoing active treatment inour Groves, Cynthia McCollum, andothers,150,000 highest level ofalertundertheleadershipNed for ourpatients. InMarch, whenMSKwent to its immediate andnimbleresponses to best care outcomes for the peoplewe care for. which we know improves thequalityoflife and Melissa Pessin, andmany others. Esther Babady, MiniKamboj, Deborah Korenstein, tests inNew York Cityundertheleadershipof food insecure, increased threefold. This pro program, whichhelpscancer patients whoare of MSKpatients whousedtheMSKFOOD Pantry were inneed.BeginningMarch, thenumber increase inthenumber ofcancer patients who hospitals stopped theirs. vital clinicaltrialsrunning,whenmany other Sabbatini alsoused telemedicine visitsto keep the leadershipofDeputyPhysician-in-Chief Paul than 50percent ofallvisits.Clinicaltrialsunder from 500aweek to almost 20,000 aweek, more patient by computer or smartphone—jumped visits —where anMSKclinicianconnects witha promise oftelemedicine areality. Telemedicine capabilities. Almost overnight, MSKmadethe MSK developed oneofthefirst COVID-19 diagnostic care. To provide robust COVID-19 testing capability, The challengesof2020 alsodemanded MSK alsoleveraged itsdigitalandtechnology MSK alsoimmediately responded to asharp gram,

President andChiefExecutive Officer CRAIG B.THOMPSON MSK’s response to COVID-19 onpage10.) and functionofthevirus.(Learn more about uncovering new detailsaboutthestructure identifying promising drugcandidates and ranging from practice-changing guidelinesto than 230COVID-19 related publications in2020, with COVID-19. AndMSKfaculty generated more desperately neededcapacityto treat people patients from nearby hospitals,freeing up far beyond ourinstitution. MSKtook incancer made to thefightagainst COVID-19 that extende people beingtreated at hospitalsoutsideMSK. 600 food-insecure cancer patients, including deliver theequivalent of90,000 mealsto some Ramirez, andLuke Paolantonio, expanded to under theleadershipofFrancesca Gany, Julia That isjust oneofthecontributions MSK

d

Governing Trustees Chair, Boards ofTrustees and SCOTT M.STUART when cancer spreads to the membranes liningthe eries last year aboutleptomeningeal metastasis, and DrugAdministration. (Learn more onpage38.) advances innew drugapprovals from theUSFood in lungandothercancers have ledto important of targeted therapies aimedat geneticmutations oncologist BobLiandothers. Their clinicaltrials the EarlyDrugDevelopment Service, andmedical from teams ledby MSK’s Alexander Drilon,Chiefof efforts willbeaided by importantnew research decline recently indeaths from lungcancer. These some ofthedeadliest cancers. important advances in2020, includingfor MSK’s singularfocus oncancer produced Clinical andResearch Advances MSK researchers alsomadeimportantdiscov You may have heard abouttheencouraging

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LETTER 8 Chief Operating Officer KATHRYN MARTIN mission. Trainees willform thenext generation trials, to patient care, andto carryingouttheMSK do iscrucialto discoveries in our labsandclinical scientific andclinicaltrainees, andthe work they educational effort. MSKhasmore than3,000 “cancer environment immunotherapy.” tumors inmice. Hecallsthisnew approach and thewound-healing process could reduce manipulating an importantplayer ininflammation SKI immunologist MingLi’s group discovered how repair could leadto cancer whendefective. And study that shedlightonhow akey step inDNA structural biologist Nikola Pavletich publisheda Scientific Information. researchers intheworld by theInstitute for members ranked amongthemost highlycited of research over thepast year, with48faculty MSK continued itspreeminence inallforms research andtreatment. (Read more onpage34.) Computational Adrienne Boire andDanaPe’er, Chairof longer with cancer. Teams led by neuro-oncologist condition isincreasingly common aspeoplelive brain andspinalcord. This particularlydifficult and scientists, andsoitwas crucialthat our of thecancer community’s leaders,physicians, needed to survive, offering new avenues for cells reprogram themselves to acquire theiron Kettering Institute, found insightsinto how cancer Central to alloftheseefforts isourvital Among many highlights,ateam ledby SKI Despite themany challengesofthepandemic, andSystems Biologyat theSloan Chief MedicalOfficer Physician-in-Chief and LISA M.DEANGELIS

Kettering Institute Director, Sloan JOAN MASSAGUÉ height ofthepandemic. to sustain MSK’s educational mission duringthe internships, training programs, andseminarseries pivoted to virtualorhybrid versions ofsummer educational leadersandtheirteams quickly & InclusionCouncil, chaired by ChiefDiversity Dr. Brown andtheOffice ofHealth Equityonpage44.) husband, Fran Biondi.(Learn more about of Trustees andGoverning Trustees, andher Jamie Nicholls,anexecutive oftheMSKBoards Health Equity, through agenerous giftfrom the creation oftheNicholls-BiondiChairfor disproportionately harmunderserved communities. to care at MSK,particularlyfor cancers that in MSKclinicalstudies andalso improve access Equality, Diversity &Inclusion bearing fruitto includemore diverse patients will expand existing MSKefforts that are already Equity Officer. Among many initiatives, heroffice surgeon Carol Brown asthefirst ChiefHealth this past year, includingtheappointmentofMSK progress, we undertook several importantsteps discrimination inoursociety, includingat MSK. overdue effort to address issues ofinequality and justice movements of2020 alsosparked along are alsolong-standing incancer care. The social consequences ofdisparitiesinhealthcare, which The pandemichighlighted thedevastating

MSK alsoestablished theEquality, Diversity To ensure MSKmakes real andenduring These efforts have beensupported by Governing Trustees Boards ofTrustees and Honorary Chair, DOUGLAS A.WARNER III

Chief Executive Officer President and CRAIG B.THOMPSON for Young Investigators; andLindeMiles,Sahana winners ofthe2020 Pershing Square Sohn Prize Finley, andAndrea Schietingerwere named Clinical Research; Vinod Balachandran, Lydia Léopold Griffuel Award for Translational and Sadelain received the49th Fondation ARC to theNational Academy ofSciences; Michel Scott Keeney andChristopher Limawere elected community alsoreceived prestigious recognitions. after undergoing arigorous examination process. designation, thehighest distinction innursing, MSK nurseswere recertified withMagnet® under theleadershipofElizabethMcCormick, the International Year oftheNurse. Inlate 2020, staff —whichseemsparticularly fittingduring that excellence isMSK’s unparalleled nursing and lungsurgery, andnephrology. time: diabetes andendocrinology, pulmonary were recognized asnational leadersfor thefirst rankings 31years ago. Three MSKsubspecialties year since U.S. News &World Reportbeganits hospitals inthecountry, asithasbeenevery was once againranked oneofthetop two cancer demonstrate theexcellence itisknown for. MSK During thepandemic,MSKcontinued to Recognition andHonors (Learn more abouttheseefforts onpage50.) a more diverse staff across theinstitution. inclusive culture at MSK,andrecruit andtrain address issues ofdiscrimination, buildamore Officer Tomya Watt. The Council’s purposeis to Many individualmembersoftheMSK One ofthemost importantcontributors to

Governing Trustees Chair, Boards ofTrustees and SCOTT M.STUART in Science (WiSE) fellowship grants, amongmany recipients ofthe2020 Marie-JoséeKravis Women Rao, andMohitaTagore were namedinaugural always beenhere. Andwe always willbe. live happier, healthierlives. BecauseMSKhas forward to pursuingourmission to helppeople for thefuture ofcancer care. led enormousadvances andischartingacourse research. Over the last halfcentury, MSKhas legislation greatly increased fundingfor cancer sometimes called“thewar oncancer,” when world marked the50thanniversary ofwhat is cancer research. and hasraised more than$275 millionfor rare for Survival —whichiscelebrating its15thyear Kids Walk for MSKKids,Fred’s Team, andCycle every year, includingthosewhoparticipate in corporations andindividualswhosupportMSK MSK employees andtheirfamilies. distributed more than$14millionto over 3,000 the MSKEmployee Relief Fund,whichwas created improve outcomes. This year that supportincluded sustains MSK’s mission to provide hopeand to thosewhosegenerous philanthropic support In 2020, more thanever, we are deeplygrateful Continued Support other recognitions ofMSKfaculty, staff, andtrainees. hardship duringtheCOVID-19 pandemicand to supportMSKcolleagues experiencing financial With your continued support,we look As thisreport went to press, themedical We are alsothankfulto thefoundations and

9 Annual Report 2020

STRENGTH 8 10 Strength and education. focus onwhat mattered most: exceptional cancer care, research, When acrisis struck, theMSKcommunity rose upwithunwavering MOMENTS OF

9 Annual Report 2020

STRENGTH 10 12 Scan here for aninteractive experience andto meetsome ofourfrontline heroes. Here isjust partofthat incredible story. technology, andtotal dedication, neitherdidthepeopleofMSK. MSK President andCEOCraig B.Thompson. Through ingenuity, institution continued theirmission. “Cancer doesn’tstop,” says found ways to maintaincriticalresearch, andeducators across the MSK teams continued to care for our150,000 patients. Scientists By March, New York haddeclared astate ofemergency. Andyet, of MemorialSloanKettering. challenges inthemore-than-135-year history the year 2020presented themost formidable As theglobalpandemictook holdoftheworld, FEBRUARY happening, a leaderindeveloping thetest. for MSK’s ClinicalMicrobiology Laboratory and laboratory andjust takinginthat, “I remember runningdown thestairs to the was deployed, MSKhaditsfirst positive case. authorized COVID-19 tests. The day after it City’s first US Food andDrug Administration- MSK developed anddeployed oneofNew York made usaneven stronger organization.” McCollum (left).“Facing thischallengetogether knew it,” says HICSIncidentCommander Cynthia communicating what we didknow, assoon as we answers, butwe wanted to make sure we were from COVID-19 infection. “We didn'thave allthe end oftheyear to protect patients andstaff become 76emergency communications by the System (HICS)issued thefirst ofwhat would February 5,theHospitalIncidentCommand MSK moved quicklywithaplanofaction.On ’ ” says Esther Babady, SectionHead ‘ Okay, thisis

monitoring system sopatients could report Reidy-Lagunes helpedadaptanexisting remote medical oncologist andHICSmemberDiane hospital amidthepandemic. Injust sixdays, Many patients were afraid to come to the care unitbedsfor COVID-19 patients.” converting 20operating rooms into intensive how to provide essential surgeries while “We beganmeetingtwice dailyto determine Perioperative &Inpatient NursingServices. for ourteam,” says Marcia Levine, Vice President, on March 7.“That’s whenthingsbecamereal emergency declared by Governor Andrew Cuomo MSK mounted arapid response to the state of of ouremployees.” self-scheduling manually ordering COVID-19 tests to a protect patients andstaff. “We went from recalls testing at MSKramped upquicklyto Infectious disease expert Monika Shah(above) system scaledupfor thousands

MARCH

with pediatric patients. MSK’s Caring Caninescontinued virtualvisits peer support,guidance, andinsight,even Caregiver SupportProgram continued to offer vaccine clinic.Volunteers inthePatient and equipment (PPE),and,later, helpinginMSK’s entrances, assisting withpersonal protective care locations, doingtemperature checksat Department fanned out across allMSKpatient About 90membersoftheVolunteer Resources Volunteers, too, stepped upto theplate. adjustment. The ‘future’ happenedovernight.” Information Officer, says, “It wasanincredible were builtfrom scratch. Atefeh Riazi,Chief strong —to work remotely. New systems it possible for many ofMSK'sstaff —21,000 A monumentaleffort by MSK’s tech team made keeping themsafe intheirown homes, allowed usto stay connected to ourpatients while COVID-19 symptoms viatelemedicine. ” “ shesays. This

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STRENGTH 12 14 •  •  of thepandemic. and patients fightingcancer inthemidst sent encouraging messages to allemployees card drive (right)for children andadultsthat keep spiritslifted. The groups organized a for pediatric cancer research, teamed upto Kettering, whichraises fundsandawareness and theScarlettFundat MemorialSloan Advisory Council for Quality(PFACQ) Members ofMSK’s Patient andFamily thanked meandwent onhisway.” expression changedimmediately. He importantly, you’re servingothers.’His worried.’ Ireassured himandsaid,‘most I asked how hewas, andhereplied, ‘very stopped by for coffee. Heseemed stressed. gift shopassociate, recalls, “Oneday anurse exhausted. Ricardo Santos (above), MSK Weeks ofworking 24-7leftfrontline workers

APRIL

Photo: Courtesy ofEmilyMcCormack Tommie, MSKKidspatient •  •  When thelive show for theimportant for MSKresearch. and more. The event raised $400,000 Steve Martin,JonHamm,EllieKemper, live Zoom performance onMay 16,featuring Mandy Gonzalez and NickKroll hosted the Saturday NightonBroadway . Theater stars was canceled, organizers virtually staged annual fundraiser Comedy vs. Cancer the DepartmentofPediatrics at MSKKids. the pandemic,” says Andrew Kung, Chairof outcome would becompromised becauseof therapies andsurgeries, ensuringthat nochild’s to pushforward withallcancer-directed were usuallymild.“Ourfindingsenabledu cancer developed COVID-19, theirsymptoms Researchers found that ifchildren with COVID-19 inchildren inJAMA Oncology. The MSKKidsteam publishedastudy about

s MAY

•  •  MSK Monmouth. says CherylBarnes,APPmanagerat need to pivot backto regular on-site care,” must-see patients butquicklyrealized the at MSKMonmouth.“We hadbeentaking for Advanced Practice Providers (APPs) May 21marked thereturn ofin-personcare Zoom session after commencement. Nobel Laureate JamesAllisoninaprivate chatted withhonorary degree recipient and dedication, andpassion.” Graduates also wound upteaching usthrough your research, of BiomedicalSciences, told graduates, “You Gerstner SloanKettering Graduate School ceremony, MichaelOverholtzer, Deanofthe of scientists. At avirtualgraduation COVID-19 didnotstop thenext generation

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STRENGTH 14 16 •  •  Physician-scientist MichaelGlickman(above) isamember ofMSK'sLaboratory Emergency Task Force, whichensured labscould reopen safely. got sickwithCOVID-19. they shouldcontinue theirtreatment, even ifthey COVID-19 illness. The study reassured patients that found that takingchemotherapy didnotworsen Chief MedicalEpidemiologist MiniKamboj (right) Publishing animportantstudy inNature Medicine, confidence intheirtreatment. differences inpatients’ understanding ofand Comprehensive Cancer Network found nosignificant patients publishedintheJournalof theNational computer orsmartphone. Asurvey ofourradiation outpatient appointmentswere telehealth visitsvia cancer care. By late June, two outofevery three MSK continued innovating to offer world-class JUNE •  •  were ableto keep goingandkeep adapting.” of HRLegal andRegulatory Affairs, says, “We after curfew. Leslie Ballantyne, Vice President documentation allowing workers to beout the hospital'sjitney service andprovided to navigate thecitysafely. MSKexpanded especially thoseworking nights—needed demonstrations took hold,employees — As COVID-19 restrictions andracial justice more than230publications related to COVID-19. colorectal cancers. In2020,MSKcontributed and sarcoma aswell aslung,prostate, and new treatments for neuroblastoma, lymphoma, our scientists helped to develop —including this year theFDA approved seven therapies four-month shutdown. Despite thepandemic, fully reopen itsresearch labsinJulyafter a MSK was thefirst institution inthearea to JULY

Photo: Courtesy of“Team MSKKids ontheMove” •  tool for clinicaltrials Telemedicine becameasuccessful of thepandemic. future MSKtrials,even after theend telemedicine willremain apartof The process was soconvenient that medical oncologist Nitya Raj(right). through telemedicine,” explains receiving treatment anddocheckups us onlywhenthey were actually was to have peoplecome to see AUGUST . “Ourgoal •  •  celebration. Runnerslike “Team MSKKidson online onOctober 29for a25thanniversary Fred’s Team community rallied together New York CityMarathon, membersofthe Despite thecancellation ofthe2020TCS midst ofahistoric crisis.” that comes from beingcalledto dutyinthe what we signedupfor. There's areal energy a medicaloncologist. “Andthat's exactly Medical Director ofMSKBergen and for thepatients,” says Matthew Matasar, seven days aweek becausewe neededto “It was six,eight,ninemonthsofworking raised nearly$90millionfor research at MSK. own marathons. Since 1995,Fred’s Team has the Move” (left)took to thestreets to runtheir SEPTEMBER OCTOBER

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STRENGTH 16 18 •  •  ANCC for itsextraordinary nurses.“The second timeMSKwas recognized by the Biomedical presented virtually at the national Annual the summer'sMSKinternship programs In November, 24undergraduates from culture that otherorganizations onlydream of.” sh appraiser was soovercome withemotion Credentialing Center (ANCC). This was th Recognition by theAmericanNurses On November 23,MSKreceived Magnet® gathered herself, shesaidMSKhasanursing and ChiefNursingOfficer. “When she Elizabeth McCormick, SeniorVice President Minority Students. Five won awards. e hadto defer to oneoftheothers,” says Research Conference for NOVEMBER e •  patients andfamilies inNew York City. wit Disparities (FOOD) program teamed up MSK's Food to Overcome Outcome the pandemic.Throughout thepandemic, to eat hasbeenanotherchallengeduring For many patients, nothaving enoughfood educational mission.” “Even inthepandemic,we advanced MSK's of Faculty Development Laura Liberman. says radiologist andDirector oftheOffice scientists ininnovative cancer research,” “We’re dedicated to training future of groceries to some600food-insecure (above) to deliver more than10,000 bags h MSKjitney drivers like Eddy Nunez

•  response to theCOVID-19 pandemic. a worldwide emergency campaignin raised onMay 5for #GivingTuesdayNow, on the$76,000 that MSK'sdonorcommunity gifts ranging from $50to $25,000. That built contributed approximately $500,000, with successful yet: More than2,500people #GivingTuesday digitalcampaignthemost MSK’s extraordinary donorsmadethe2020 DECEMBER

•  “Let’s dothistogether.” Services (above withnurseBriannaZappi). Chris Choudhry, Director ofEnvironmental an example andprotect ourcommunity,” says were vaccinated. “This isourchance to set month, more than10,000 MSKemployees dose oftheCOVID-19 vaccine. Inthefirst rolled uptheirsleeves to gettheirfirst of December, healthcare heroes at MSK At last, new hopeemerged. Inthemiddle

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STRENGTH 18 20 Meet just some oftheseheroes. COVID-19 pandemic. stepped upinextraordinary ways duringthe Memorial SloanKettering staff, patients, anddonors FRONT LINES FROM THE

1921 Annual Report 2020

STRENGTH 20 22 keep the shipsailing.Duringheightof troubleshooting technology andlogistics to we had.” Mr. Cortellesi alsospenthisdays based onbest practices andtheequipment Mr. Cortellesi says. “We madeitupas we went, MSK’s supply ofPPE.“There was nostandard,” emergency response team to manage In March, hebecameacoordinator for MSK’s to assist withCOVID-19-related operations. clinical andnonclinicalemployees redeployed MSK’s DigITs group, was oneofhundreds of Mr. Cortellesi, aseniorsystem architect in volunteered to jointhefront linesat MSK. ramp up, heleaptinto actionandimmediately times gettough. So, whenCOVID-19 started to hometown, Paul Cortellesi doesn’tflinchwhen As afirefighter andEMTinhis New Jersey Senior system architect, Digital,Informatics &Technology Solutions(DigITs) PAUL CORTELLESI

I definitely meanit.” it was my favorite three monthsofmy career, service duringthepandemic.“When Isay Mr. Cortellesi says hewillnever forget his distant get-togethers at hisfamily farm. thanked hisfellow staffers by hosting socially hook onto. Over thesummer, Mr. Cortellesi buttons to hissurgical capthat themaskcould strain oftheN95maskonhisears:Shesewed came upwithaningeniousway ofreducing the and care packages at thehotel, andhiswife challenges. Family andfriendssent himcards support network” for liftinghimupduringthese distance ofMSK.Hecredits his“enormous Easter —andsleptat ahotel withinwalking consecutive days —even on weekends and the first wave, Mr. Cortellesi worked 41

care oftheirown.” Still, sheworried about an unspoken rule,” she says. “Nursestake Ms. delaRosa jumpedinto action.“There’s nursing colleagues fell illwithCOVID-19, required more care. When oneofher usually hadmore advanced diseaseand Those whodidcome to thehospital virus. The consequences were serious. hospital for care becausethey feared the patients were reluctant to come to the At thepeakofpandemic,many cancer Certified registered nurseanesthetist (CRNA) APRIL delaROSA Also pictured onpage11 her MSK’s CRNAoftheYear for 2020award. way,” shesays. Herskilland dedication earned to alsobecompassionate every step ofthe the trust my colleagues gave meearlyonbut positivity. “Mychallengewas to notonly keep Ms. delaRosa braved therisksandledwith who inadvertently exposes someone?’” But I was always thinking,‘Could Ibetheone surveillance screenings aswell asPPE,but those underhercare. “We hadweekly

2321 Annual Report 2020

STRENGTH 22 22 24 much-needed goodsfor frontline workers. in-kind donations ofPPE,food, andother childcare, groceries, andmore. employees received grants to helppay for rent, earmarked for greatest needs.More than3,000 to assist employees, including donations both theCOVID-19 Fundandotherdonations, million ofphilanthropic funds,drawing from the homefront, MSKallocated atotal of$14 research andinnovation, oremployee relief. Fund, designating giftstoward greatest needs, — contributed $6.3millionto theCOVID-19 Board members,andpeoplearound theworld 3,000 donors—includingMSKstaff, MSK during theCOVID-19 pandemic. More than meet theinstitution’s unprecedented needs The MSKdonorcommunity swiftly united to MSK’S DONORCOMMUNITY Senior Project Manager, Construction, helpsortdonations of PPE. Debbie Parmet-Sondock (left),MSKvolunteer, andDonnaSbriglia, Donors' generosity alsoextended to Recognizing thepandemic'schallenges on

were posted allover thehospitalandshared messages to MSK’s healthcare heroes, which They even wrote more than2,000 thankyou at MSK. Chain andSustaining Care Services Operations says LisaLieberman,Senior Director ofSupply generosity ofouramazingdonorcommunity,” because ofoursupplychainexperts andthe we neededto provide thebest cancer care 8,500. “MSKwas ableto procure everything procedure masksaday —upfrom theusual April 2020,for example, MSKused32,000 number to keep patients andstaff safe. In standard cost, and MSKrequired ahigher some items rose to nearlyten to 14timestheir could notscaleupfast enough.Prices for supplies accelerated, traditional supplychains by emailto provide encouragement. As globaldemandfor PPEandcritical

Perioperative nurseliaison ELIZABETH FARRAT clinics aswell assurgeries running smoothly. nursing inJuly. Telemedicine was keeping the ICU, Ms.Farrat returned to perioperative months ofcaringfor COVID-19 patients in else to keep themsafe,” shesays. After four moved inwithherparents. “Ididn’tknow how her deployment, herhusbandandchildren also afraid oftheunknown.” Four days before who were sogravely ill,” sherecalls. “ButIwas the knowledge andskillto care for patients critically illCOVID-19 patients. “Iknew Ihad in March andinto new territory caringfor after surgery, stepped outofherregular role who cares for patients before, during,and Elizabeth Farrat, aperioperative nurse liaison

says hercolleague Evangelina SantaTeresa. the humantouch to eachnurseandpatient,” during theCOVID-19 pandemic.“Shebrought gone above andbeyond inproviding care achievement that recognizes nurseswhohave the 2020The Finest Houraward, anational For hertireless efforts, Ms. Farrat received ways that thecare at MSKisexceptional.” they felt cared for. Andthat isoneofthemany not ableto bepresent ontheday ofsurgery, them,” shesays. “Even thoughfamilies were updating theminpersonto callingandtexting change from meetingpatients’ families and information withfamilies. “Myrole hadto It was anew tool for sharingcritical

2325 Annual Report 2020

STRENGTH 24 26 for anhourortwo to take care ofthings week, Icameinto thelabalone andstayed scientists stay ontrack. “Once or twice a died ofCOVID-19. Ms.MenocalhelpedMSK personal. Hercousin, adoctor inMexico, many, like Laura Menocal,thework was could continue despite thepandemic.For Force was created to make sure research In March, theLaboratory Emergency Task PhD student inthelabofAndrea Schietinger LAURA MENOCAL important discoveries,” she adds. research becausewe are makingsomany very excited aboutwhat’s aheadincancer picking upmy work again,” shesays. “I’m Ms. Menocal’s work. “Itwas very smooth are upandrunningagainthanksinpartto avoid COVID-19 exposure. Today, thelabs selfless efforts meanther colleagues could that were necessary,” Ms.Menocalsays. Her Photo: Courtesy of RachelZitofsky and Leah Blanton from Floridato beby herside. Littledidthe all theway,” Rachelrecalls. through thistogether andshe’d supportme removed. “Dr. Sclafani told mewe’d get had bothbreasts, ovaries, andfallopian tubes and ofdeveloping ovarian cancer, Rachel increasing herriskofasecond breast cancer revealed aBRCA2 mutation, dramatically testing through MSK’s ClinicalGeneticsService by breast surgeon LisaSclafani. Memorial SloanKettering Commack, led build acare team closeto herhomeat a pandemic,Rachelwas grateful she could With theaddedstress of facing cancer during the news: Shehadstage IIbreast cancer. when 38-year-old RachelZitofsky (left)got The COVID-19 pandemicwas raging inApril Sisters andMSKpatients RACHEL ANDLEAH Rachel’s sister, Leah Blanton, traveled When telemedicine visitsandgenetic

how longthispandemiclasts, I’d rather be have preventive surgeries at MSK.“Nomatter hospital duringthepandemic,shechoseto mutation. Despite concerns aboutbeinginthe MSK, shelearnedthat she, too, hadaBRCA2 When Leah decidedto have genetictesting at lifesaving information for heroldersister, too. sisters know, Rachel’s diagnosiswould uncover through —hercancer saved my life. Leah says. “ButIsaw what my sister went radiation. It could have beensomuchworse,” grown, andIcould have neededchemoand “If Iwould have waited, that cancer could have breast cancer, orductalcarcinoma insitu. her preventive surgery showed early-stage learned that tests onthetissue removed during here to watch my kidsgrow up,” she says. As RachelandLeah were recovering, Leah ”

2527 Annual Report 2020

DISCOVERY 26 28 Discovery of themost pressing challengesincancer science. MSK researchers are makingstrides to address some Through ingenuityandsheerdedication to saving lives, MOMENTS OF

27 Annual Report 2020

DISCOVERY 28 30 change whenthey metastasize. In herlab, physician-scientist Karuna (leftandabove) Ganesh studies how cancer cells that were intheprimarytumor.” says. “They have thesamemutations, thesamealterations, already gainedsomeimportantinsights. regular tumorcells isDr. Ganesh’s lab’s mainfocus, andthey’ve difficult togetrid of.” stress oflivinginanew environment, andthat makes themvery Sloan Kettering Institute. “They’re more equippedto survive the who bothtreats patients andhasherown research labinthe a JosieRobertson Investigator at MemorialSloanKettering from thetumorthat they started offin,” says Ganesh, Karuna cells themselves. of theparticularlyaggressive tendencies ofmetastatic cancer are harmedby cancer’s relentless expansion butalsobecause harder to cure. That’s notonlybecausemore partsofthebody cancer deaths. Once acancer hasmetastasized, itismuch the situation isgrave. metastasized, canfeel like adeath sentence. Andindeed, diagnosis itself, learningthat thecancer hasspread, or and onethat nopatient wants to hear. Beyond acancer “Your cancer hasspread.” Itisaphrase saidtoo many times, TUMORS FROMSCRATCH RESEARCHERS GROW CANCER MYSTERIES, TO SOLVE STUBBORN “Genetically, thesecells are exactly thesame,” Dr. Ganesh Finding outwhat distinguishes metastatic cancer cells from “Metastatic cancer cells are acompletely different entity Metastasis is responsible for more than90percent of

31 Annual Report 2020

DISCOVERY 32 notably, they produce aprotein calledL1CAM. metastasis stem cells. an organoid. Those that canare called sample are equallycapableofgrowing into is that notall thecells inametastatic tumor and publishedinthejournalNature Cancer , change over time. organoids inthelabandwatch how they for theircancer. They canthengrow these obtained from patients undergoing surgery generate colon cancer organoids from cells Dr. andherteam Ganesh have beenableto experiments inlabmice never could. cancer, providing information that conducting transforming theway researchers at MSKstudy more realistic conditions. The technology is them to study theprocess ofmetastasis under organoids from patient tumorsamplesanduse and function.MSKscientists cancreate of cells that resemble organs intheirstructure As theirnamesuggests, organoids are tiny balls Disease inaDish technology calledorganoids. MSK colleagues have turnedto aninnovative this importantproblem, Dr. andher Ganesh conventional approaches. That’s why, to tackle treatment weapons. to evade destruction by even ourbest Plasticity alsoallows metastatic cancer cells lung orthecolon —wherever they originated. to adaptandsurvive outsidethebreast orthe different genes. to changetheirbehavior by turningonandoff from primarytumorcells isaheightened ability They have someuniqueproperties. Most One thingthey’ve learnedthispast year, Working withMSKcolorectal surgeons, Yet plasticity isdifficult to studywith Plasticity allows metastatic cancer cells Scientists callthisplasticity. But what distinguishes metastatic cells distant vitalorgans.” — thetumorin thewrong place — the regeneration ofthewrong tissue “We now understand metastasis as — JoanMassagué, Director, SloanKettering Institute of thisresearch. leadership, SKIcontinues to beat theforefront to galvanize theresearch paradigm. Underhis fundamental discoveries inthisarea andhelped Institute, whoselabhasmadesomeofthe Joan Massagué, Director oftheSloanKettering in thewrong place —distant vitalorgans,” says regeneration ofthewrong tissue —thetumor of thebodywhere they have taken upresidence. cells helpto regrow thetumorinanotherpart to repair adamagedorgan, themetastasis stem In otherwords, instead ofgrowing new tissue normal bodytissues useto repair themselves. metastasis relies onthesamepathways that effectively spread to new sites inthebody. metastasis. Cells that cannotmake L1CAMcannot wound, andthenstart to fillitinwithnew cells. from theirneighbors,migrate into thegapofa itself. Stem cells makingL1CAMcanseparate cells ispartoftheway that thecolon repairs the bowel. Activating L1CAMintissue stem may becolitis, aninflammatory condition of response to injury. Inthecolon, that injury tissue repair process that isturnedonin This sticky moleculeisanormalpartofthe Courtesy lab ofAhmedMahmoud,Ganesh (in green) andnon-dividingtumorcells (inpink).Image: This colorectal cancer organoid shows dividingtumorcells “We now understand metastasis asthe More andmore, scientists are learningthat But itturnsoutthat L1CAMisalsocrucialfor — to identifyapossible culpritinthebrain cancer glioblastoma. Physician-scientist Viviane Tabar's labusesorganoid technology —tiny ballsofcells from apatient's tumor who ledtheresearch. “We can’tsay with Chair ofMSK’s DepartmentofNeurosurgery, other,” says physician-scientist Viviane Tabar, that we have identified are sosimilar to each the developing brain andthe tumorstem cells home —buthave notbefore beenlinked to cancer. travel alongthemlike train tracks to reach their in buildingfetal brains —newly birthedneurons radial gliacells. Radialgliacells play akey role Reports that identified apromising suspect: scientists at MSKpublished astudy inStem Cell this past year whenamulticenter team ledby had few leadsto search for them.That changed been ableto determine thesecells’ identityand glioblastoma. Upuntilrecently, scientists hadn’t root ofadifficult-to-treat brain cancer called Stem cell plasticity isalsobelieved to beat the in theBrain Hunting Down Cancer Stem Cells their abilityto metastasize. block L1CAMandthereby rob cancer cells of they are currently lookingfor drugsthat might approaches. InDr. Ganesh’s lab, for example, gone wrong opensuppotential treatment “The lookandbehavior of radial gliacells in Viewing metastasis asregeneration hopefully solve themystery ofthisbrain cancer. they can begincollecting more evidence andcan much like radial gliacells.” of thebrain cells backinto cells that lookvery epigenetic changesinthecancer turnsome The otherpossibility isthat thegeneticand fetal radial gliacells in ourbrains asadults. them, that may meanthat humansretain some explains. “Ifglioblastoma tumorsarisefrom thought to persist inadulthood,” Dr. Tabar tumor tissues taken from patients. unusual cells alsowere present indozens of dance, muchlike radial glia. tails anddividedinanunusualsynchronized that somecells intheorganoids hadvery long from patients to grow organoids. Shenoticed using tumortissue that hadbeenremoved a research associate inDr. Tabar’s lab, was crucial to makingthediscovery. Rong Wang, on thecandidate list.” tumor stem cells, butthey are now very high certainty that radial gliacells are thesameas “Radial gliacells previously were not Further analysis confirmed that these Once again,organoid technology was Now that Dr. Tabar’s team has aleadsuspect,

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DISCOVERY 34 and right)to devote herscientificcareer to conquering a form ofmetastatic cancer. An unforgettable encounter withapatient inspired neuro-oncologist Adrienne Boire (above and wreak havoc. there ismore timefor thediseaseto spread to thespinalfluid patients livinglongerbecauseof better treatments, itmeans to solve LM, anincreasingly urgent clinicalproblem. With cancer died, buthermemorylives onthrough Dr. Boire’s determination got to work,” shesays. The year was 2014.Sadly, thewoman a list ofquestions together andthenIwent rightto thelaband hospital room, andsat withher, takingnotes. “We cameup with doing withmy life.’” suddenly realized, ‘This woman istelling mewhat Ishouldbe Massagué. “Ipushedtherevolving doorinto Zuckerman and in thelaboratory ofSloanKettering Institute Director Joan Zuckerman Research Center, where shewas aresearch fellow mind, Dr. Boire crossed thestreet from MemorialHospital to think was, ‘Metoo.’” ‘I really wishsomeonewould figure thisout,’ andallI could have any goodanswers for her,” Dr. Boire recalls. “Shesaid, happening andwhy there weren’t better treatments, andIdidn’t of metastatic cancer calledleptomeningeal metastasis (LM). control. Shewas suffering thedevastating effects ofa form had terrible headaches,andhadlost bowel andbladder her spinalfluid.Now the woman could nolonger walk, breast cancer —seeminglyundercontrol —hadspread to Her patient was upsetandcouldn’t understand how her Neuro-oncologist Adrienne Boire was at aloss for words. CANCER’S SPREAD DETERMINED TO DEFEAT Dr. Boire turnedaround, went straight backto thewoman’s With that difficult conversation still verymuchonher “She hadalotofquestions for meaboutwhy thiswas

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DISCOVERY 36 barren environment explain how LMcells survived inthemostly the bloodto enter andsustain thecancer cells. and allows growth factors andnutrientsfrom membrane between thebloodandspinalfluid They found that aprotein calledC3opensthe Massagué labstudied humanLMcells inmice. to supportcell growth. barrier andthespace isdevoid ofnutrients sealed offfrom the rest ofthebody by atight there. The brain andspinalcord are largely manage to survive inspinalfluidafter spreading has longpuzzledresearchers: how LMcells These key findings relate to somethingthat Hardy Cancer Cells combination ofclinicalandlaboratory expertise. discoveries resulted from MSK’s unparalleled raised hopesfor aneffective treatment. The has already produced criticalinsightsand the mystery ofthisdauntingcomplication Dr. Boire — whonow leadsherown lab— the individualcancer cells inexquisite detail. secret power would beto study the activityof question was: How? The only way to findthis Yet some ofthecancer cells persevere. The cancer cells, competing for thesamenutrients. the spinalfluidand vastly outnumberthe This discovery, however, didnotfully In 2017,Dr. Boire andcolleagues inthe Six years later, Dr. Boire’s resolve to crack To conduct thiskindofdeepanalysis, what Ishouldbedoingwithmy life.’” her. Isuddenlyrealized, ‘This woman istelling me treatments, andIdidn’thave any goodanswers for why thiswas happeningandwhy there weren’t better “[The patient] hadalotofquestions for meabout . Immunecells also invade — Adrienne Boire, Neuro-Oncologist protein,” Dr. Pe’er says. “The cancer cells not on thesetofgenesto make thelipocalin-2 to survive. protein bindsto iron, whichLMcells need to produce aprotein calledlipocalin-2. This critical feature: They reprogramed themselves sample. Butallthecancer cells shared one among thecancer cells —even withinthesame This revealed many differences inRNAactivity LM that hadspread from breast orlungtumors. taken from five patients whohaddeveloped single-cell RNAsequencing onfluidsamples the spinalfluid,” Dr. Boire says. granular level how thesecancer cells live in wide netsowe could understand at areally genes are expressed, or“turnedon.” within individualcells to determine which researchers to lookat RNArather thanDNA study cancer onecell at atime. This enables philanthropy, whichusesnew technologies to Initiative, also supported by theGerrys’ metastasis research. in 2017andprovides criticalfundingfor Ecosystems Center, whichwas established Alan andSandra GerryMetastasis andTumor cell analysis. Dr. Pe’er isScientificDirector ofthe Dana Pe’er, aworld-renowned expert insingle- collaborated withSKIcomputational biologist “Normally, onlyimmunecells canturn The researchers conducted atest called “I knew Danacould helpmecast avery Dr. Pe’er oversees theSingleCell Research new environments. metastatic cancer cells individually, offering a deeperunderstanding oftheiractivityandhow they adapt to Computational biologist DanaPe’er (above) usedherexpertise insingle-cell analysis to helpDr. Boire study showed that delivering chemicalcompounds iron? Inmousemodelsfor thedisease, they question: What ifyou could cutoffaccess to lipocalin-2 ledtheresearchers to theirnext in thejournalScience inJuly2020. one trickthat seemsto work,” Dr. Pe’er explains. adapt to theharshenvironment by usingthe evolution indrivingthesediverse cancers to to pickupmore paperclips. them. It’s like creating amuchstronger magnet immune response that would normallydestroy cancer cells to monopolize theiron, foiling the The increased lipocalin-2levels enablethe Breaking theCancer Cells’ GriponIron efficiently thanintheimmune cells.” charge itto work athousandtimesmore only access thisgeneticprogram buthyper- Identifying thekey role played by The researchers reported thisfinding “It shows thevery powerful force of be doinghere.” like Iremembered something—what Ishould I forgot something,” shesays, “butit’s more her patient that day in2014. incentive is what drove herbackto speakwith patients endure suchadifficult condition. This motivated rather thandespondentafter seeing long vexed researchers andcliniciansalike. effective treatment for a condition that has therapy to aclinicaltrial.Itcould bethefirst The researchers are now working to bringthis taking itaway. Nobodygetsit,’” Dr. Boire says. over atoy andtheparent says, ‘That’s it—I’m away thecancer cells’ survival advantage. iron soless isavailable to allthecells, taking slowed theirgrowth. The chelators bindto the deprived thecancer cells oftheirlifeline and called iron chelators directly into thespinalfluid “The securityguards probably thought Dr. Boire says herlabwork helpsherstay “It reminds meofwhenkidsare fighting l

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DISCOVERY 36 38 grow anddivide. and larotrectinib turnoffthe signalsthat tell cancer cells to cancer, targeted therapy drugslike selpercatinib, entrectinib, Unlike therapies that activate the immunesystem to fightthe mutation orfusion,targeted therapy canwork muchbetter.” if thesedrugsare anoption.“Butfor cancers causedby a cancers,” Dr. Drilonsays, adding that hispatients often ask changes. “Immunotherapy canwork extremely well for some therapies for cancers, includingthosewithspecificgene mostly sparinghealthy cells. the cancer-causing genesanddirectly attack tumorswhile fusions. Allofthesedrugsare targeted therapies, whichblock was approved for adultandpediatric tumorsdriven by NTRK NTRKfusions.InNovemberby 2018,larotrectinib (Vitrakvi®) lung cancer driven by ROS1 In August 2019,entrectinib (Rozlytrek lung andthyroid cancers driven by RETfusionsormutations. improvement whenthey've runoutofother options. Lauren Kaplanis) says targeted therapies canhelpsomepatients achieve a"Lazaruseffect" — dramatic Chief oftheEarly DrugDevelopment Service Alexander Drilon(leftandabove withclinicaltrialsnurse In May 2020,selpercatinib (Retevmo and Dr. Drilon’s team, working withpharmaceutical companies. Administration hasapproved three drugsdeveloped by theEDD their lives theway they didpriorto theircancer diagnosis.” symptoms dramatically improved, andthey went backto living therapy thenachieved aLazaruseffect —theircancer-related Kettering’s EarlyDrugDevelopment (EDD) Service. “Targeted death’s door,” says Alexander Drilon,ChiefofMemorialSloan “We’ve seensickpatients whowere practically knockingon TRANSFORM LIVES NEW TARGETED THERAPIES Doctors intheEDD Service specialize indeveloping new In just thepast three years, theUSFood andDrug fusionsandallcancers driven TM TM ) was approved to treat ) was approved for

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DISCOVERY 40 the start oftheselpercatinib trialin2017,there fusions andlung cancer since 2011, but priorto with thisdrugsofar.” many ofthenearly100peoplewe’ve treated works withDr. Drilon. “Anditwas repeated in says Lauren Kaplanis, aclinicaltrialsnursewho be here today withoutit.” says 66-year-old Melissa. “Idon’tthinkI’d still every day andisamazed to feel sowell. since April2020.She continues to take thepill subsided. Shehashadnoevidence ofdisease The extreme fatigue shefelt inthebeginning ber, ascanshowed hertumors were shrinking. of selpercatinib, taken asapill.By Septem- “Then Ilearnedaboutthetrialat MSK.” but together they kept mealive,” shesays. other clinicaltrials.“Noneofthemworked well, cancer for 12years andhadbeenthrough five time inApril2017,she’d beenlivingwithlung Drilon’s work. patients whoselife was turnedaround by Dr. music teacher Melissa Crouse isoneofthe Florida grandmother andretired middleschool A Second Chance for aBornTeacher a clinicaltrialat MSK. “I don'tthinkI'dstill behere today withoutit,” says patient andadvocate Melissa Crouse aboutatargeted drugshereceived in “We’ve known aboutthelink between RET “Melissa’s experience was remarkable,” “Selpercatinib was my sixthclinical trial,” That June, Melissa received herfirst dose When Melissa metDr. Drilonfor thefirst because ofthe shapeoftheKRAS protein. considered to be“undruggable” mutations of lungcancers, anduntilrecently they were KRAS a common mutation inagenecalledKRAS first-ever clinical study of a drugthat targets the New EnglandJournalof Medicinefrom the Lito andBobLireported dramatic results in In September 2020,physician-scientists Piro focused ontargeted therapies for lungcancer. IMPACT™, adiagnostic test developed at MSK. cancer-causing genes canbedetected withMSK- mutations. ChangesinRETandhundreds ofother Renegades” for otherswithRETfusionsor Melissa even started agroup calledthe“RET they’ve become common lingofor patients. molecular testing andpersonalized medicine, ALK, ROS1, NTRK—butinthisexciting era of changes soundlike analphabetsoup—EGFR, powerful drugs.The genesaffected by these gene changestargeted by anew class ofmore RET fusionsormutations are oneofmany The New Frontier more sideeffects. Other drugswere less effective andcausedalot target onlytheRETprotein,” Dr. Drilonsays. were nodrugsthat were designedto optimally Dr. Drilonisnottheonlyspecialist at MSK mutations are found inabout onequarter . what Iknow now, I wouldn’t have retired.” selpercatinib trial.She says, “If Ihadknown then had leftherteaching jobwhenshe started the called Melissa’s Story. winning documentaryabout lungcancer advocate, even starring inanEmmy Award- therapies for cancer patients everywhere. being treated by theEDDService —it’s changing difference notonly for his own patients andthose people canaccess thesenew treatments.” by regulatory agenciesaround theworld, more Dr. Drilonsays. “When thesedrugsare approved these drugsfor years andare still doingwell,” standard therapies. Ihave patients whohave taken therapy that they may never attain withother offer select patients outcomes withtargeted important work, aswell asDr. Li’s research. research withRETgenechanges,amongother Research at MSKprovided fundingfor Dr. Drilon’s Stanley Druckenmiller Center for LungCancer investigators intheEDDService. The Fionaand Philanthropy hasprovided criticalsupportfor the Expanding Access Beyond ClinicalTrials are continuing to study sotorasib inclinicaltrials. Thoracic Oncology Services. Dr. LiandDr. Lito way,” addsDr. Li,amemberoftheEDDand the first to crack KRAS and Pathogenesis Program. Oncology Service andtheHumanOncology Dr. Lito, whoisamemberoftheThoracic directly target KRAS number ofemerging therapeutics aimingto designated sotorasib aBreakthrough Therapy. side effects. Basedonthese results, theFDA people hadto stop takingthedrugbecauseof responding to thedrugten monthslater. Nine substantially, andhalfofthemwere still growing. Ofthose, 46patients’ tumorsshrank G12C hadtheirtumorseithershrinkorstop caused by aKRAS II trial,100of126patients whosecancer was Symposium that intheregistrational phase World Conference onLungCancer Presidential greater motivation. Their work hasmadea Nonna’s Garden Foundation. received supportfrom Mike Repole andhis pathbreaking work intheEDDService hasalso A self-describedtypepersonality, she Melissa isnow anactivist andpatient “Through theEDDService, we are ableto “Sotorasib isnotacure, butthisstudy is “Sotorasib isthefirst amongagrowing In January2021,Dr. Lireported at the For Dr. Drilonandhisteam, there isno mutation calledKRAS- -mutant cancers,” says inaclinicallymeaningful Other

l "undruggable," bringinghopeto patients inneed. one quarter oflungcancers isnolongerconsidered (top) andBobLi(above) meansamutation found in Critical work ledby thoracic oncologists Piro Lito

41 Annual Report 2020

CHANGE 40 42 Change more diverse andinclusive community for all. MSK iscommitted to breaking down barriersandcreating a MOMENTS FOR

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CHANGE 42 44 of gynecologic surgeon Carol Brown (above andleft). A deepcommitment to equityinhealthcare hasbeenahallmark ofthedistinguished career race, ethnicity, orsocioeconomic status. disparities inhealthcare —particularlycancer care —basedon Dr. Brown hasbecome anational leaderintheeffort to eliminate long have not gotten thecare they deserve.” “you canchangepeople’s lives, includingpeoplewhofor too and therightsocialsupporttools,” sheexplains, access andoutcomes canbeovercome. “With therightscience convinced her that long-standing disparitiesinhealthcare “The qualityofcare hereceived saved hislife.” in anormalrhythm —fighting to keep himalive,” shesays. at this one patient’s bedsidefighting to keep hisheartbeating for hisrare heartarrhythmia. Itfelt like we spent18hoursaday the ICUtreating amaninhis50swithanexperimental medicine who neededitmost buthadtheleast access. firsthand the benefitof providing cutting-edgecare to those spent many rotations at HarlemHospitalwhere shewitnessed and thefirst recipient oftheMalcolm XScholarship, Dr. Brown being President oftheBlackandLatino Student Association student at Columbia University inthe1980s.Inadditionto to equityinhealthcare was forged duringhertimeasamedical For gynecologic cancer surgeon Carol Brown, acommitment Reducing Cancer Disparities Carol Brown Leads aNew Commitment to HEALTHCARE AVAILABLE TO ALL CLOSING THEGAP:MAKING During hermore than25years at MemorialSloanKettering, Dr. Brown says that experience andmany othershave “I was partofanall-Blackteam ofexceptional physicians in

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CHANGE 46 happen,” Dr. Brown (above) saidat apartnershipevent withNassau County to distribute vaccines. “It’s essential that thislifesaving COVID-19 vaccine get to thepeoplewhoneed itmost, andMSKiscommitted to makingthat of color at thehandsoflaw enforcement rocked Dr. Brown. Then, shesays, “The deaths ofpeople could determine wholives andwhodies,says disparities —especiallythosebasedonrace — country andat MSK.” year “raised anew consciousness around the andbelieves“game changer” thistumultuous too many people. Dr. Brown says 2020was a disparities incancer threaten the lives offar Despite somerecent gains,long-standing Changer’ ‘Game Cancer Disparitiesanda socioeconomic status.” ability, thelanguagethey speak,ortheir gender identity, sexual orientation, physical outcome regardless oftheirrace, ethnicity, all peoplewithcancer achieve thebest possible is to make sure MSKisalsoaleaderinhelping says. “Ourvisionfor theOffice ofHealth Equity high-quality care andlifesaving research,” she leading cancer center intheworld interms of first ChiefHealth Equity Officer. “MSKisthe to thisissue by appointingDr. Brown asMSK’s In 2020,MSKmadeamajorcommitment First, COVID-19 revealed that health Family Ties working towards canreally happen.” shows usthat thegoalsofhealthequitywe’re to reduce andeliminate cancer disparities.It and somany othersat MSKwho have worked gift by Ms.NichollsandMr. Biondiinspires me Fran Biondi.Dr. Brown says, “The generous MSK by JamieNichollsandherhusband Nicholls-Biondi Chairfor HealthEquity at endowment inDecember 2020ofthe of thelarger MSKcommunity, suchasthe so Ilearnedaboutitat thedinner for Blackpeople inSouthCentral Los Angeles, talk alotabouttheissues ofhealthcare access a young girl,Dr. Brown recalls that “hewould African Americansurgeons. When shewas Charles E.Brown, was oneofthecity’s first and raised inLos Angeleswhere herfather, planted inherchildhood.Dr. Brown was born For Dr. Brown, theseedsofpurposewere and healthequityhasrisento awholenew level.” This year thecommitment to diversity, inclusion, says Dr. Brown, was that “theinstitution listened. our institution andourstaff.” The result at MSK, She isalsoencouraged by thereaction table.”

Now you cantoo.’” that we love say to them,‘OK,Aldidit. helps thoseofuswhohave Blackmen continued, “You stepping forward really and bloodtests, andthat’s difficult.”She “Prostate cancer involves rectal exams going publicabouthisdiagnosis.Shesaid, for avideochat, and shethanked himfor the JosieRobertson Surgery Center. Vincent Laudone, ChiefofSurgery at surgeon, MemorialSloanKettering’s his cancer diagnosisalongwithhis diagnosed withprostate cancer. Al Roker decidedto dowhenhewas is precisely what beloved TVnews anchor to raise awareness aboutthem.Andthat One key to reducing cancer disparitiesis CANCER DISPARITIES SHINING ASPOTLIGHT ONPROSTATE Photo: Courtesy ofNBCUniversal In February 2021,Al joinedDr. Brown On NBC’s Today show, Alrevealed Scan here to watch Dr. Brown andAlRoker’s conversation.

as simplethat.” he said,“peopleare goingto die. Ithinkit’s don’t allhave access to good healthcare,” patients are asfortunate asheis.“Ifwe of ourpublicheath hospitalsystem.” it’s really not.” as somesortofweakness, needto realize Black men,whoseegoingto thedoctor key messages because“men,especially like MSKandcancer centers that are part get access to high-qualitycare at centers higher riskfor different typesofcancer can to advocate sothat allpeoplewhoare at at MSK.Dr. Brown responded, “We want Al told Dr. Brown that’s oneofhis Al noted thegrimreality that notall Al praised theexceptional care hegot

l

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CHANGE 48 have access to cutting-edgetherapy.” in QueensandBrooklyn whootherwisemay not gists to bring MSKclinicaltrialsto their patients partners withdedicated community oncolo- munities. Dr. Brown explains that “CHERP for underserved patients intheirlocalcom- ditional hospitalsthat provide cancer care Research Program (CHERP)to includead- expand theexisting Cancer HealthEquity on allthesefronts —andmore. Shewill populations ofpeopleindifferent ways.” result oftumorbiologythat affect different cases, shesays, “cancer disparitiesmay bethe may beaboutaccess to screening.” Inother reasons: “Itmay beaboutaccess to care orit that cancer inequitiesexist for many different those life lessons into action.Sheexplains In hermedicalcareer, Dr. Brown hasturned More Access, Outreach, andInsight healthcare delivery system.” for peopledespite theeffects of racism onthe and biguniversities to really solve problems positive changeandwork withhealthsystems father’s efforts “showed that you could affect Angeles. Shecameto understand that her King, Jr. General HospitalinSouthCentral Los Postgraduate MedicalSchoolandMartinLuther early 70s,hehelpedfound theCharlesR.Drew how to create solutions:Inthelate 1960sand Laura (right)andNicole. Photos: Courtesy ofCarol Brown Right: (clockwise from top) Dr. Brown's father, Charles EmersonBrown; Dr. Brown asa littlegirl;Dr. Brown withherdaughters, Source: AmericanCancer Society five-year survival rate thanwhite women Black women have a20percent lower ENDOMETRIAL CANCER a 40percent higherdeath rate at thesamerate, butBlackwomen have Black andwhite women are diagnosed BREAST CANCER develop itandtwice aslikely to dieofit Black menare 50percent more likely to PROSTATE CANCER Disparities The GrimReality ofCancer Dr. Brown plansto attack cancer disparities Her father alsosetapowerful example of

care andrespect they deserve. devoted to helpingeveryone receive the years ago— andhashelpedforge acareer helped save adesperately illmansomany same determination andcompassion that disproportionately from cancer.” to helpunderserved communities that suffer from every walk oflife andthat reaches out known asaplace that’s welcoming to people not accessible.” She wants MSK“to become as aplace that’s hard to getinto —that it’s often, shesays, “MSKhasbeenperceived anyone how many challengeslieahead.Too disparities, Dr. Brown knows better than After decadesofworking to reduce cancer The Road Ahead immunotherapy andtargeted therapy.” MSK that really make adifference, including risk andaccess to treatments andresearch at for thisdisease have knowledge abouttheir “We want to make sure thewomen most at risk types ofendometrialcancer.” Dr. Brown says, Black women tend to getmore aggressive experienced by women ofcolor isbecause that “onehypothesis aboutthelower cure rates symptom: abnormalbleeding.Sheexplains of gettingevaluated for itsmost common endometrial cancer andtheimportance educate Blackwomen abouttheirriskof white women intheUnited States." women isactuallygettingworse compared to Brown, “andthedifference inoutcome for Black rapidly over thelast four to five years,” says Dr. mortality for thiskindofcancer hasbeenrising on endometrialcancer. “The incidence and newly diagnosed.Oneofherefforts focuses to less-advantaged peoplewhenthey are in thefirst place as well asprovide MSKcare would nototherwisehave access to. eligible for clinicaltrialsortherapies they to particulardrugs.Ithelpsidentifypatients to findtumormutations that are vulnerable a test that analyzes more than500genes patients have benefited from MSKIMPACT™, To achieve that goal,shewilldraw onthe To help, Dr. Brown isleadingefforts to She alsowants to helppeopleavoid cancer For example, hundreds ofunderserved l

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CHANGE 48 50 American andPacific Islander community (left),andwill shapethefuture of MSK. efforts continue in2021with events like the momentofsilence inAprilsupport oftheAsian In 2020,MSKlaid thegroundwork for creating amore diverse andinclusive institution. These critical areas across MSKshared theirperspectives. People whoare helpingto leadthese changesinmany cared for whenthey come to MSK. Every patient must feel welcomed, understood, andwell opportunities andto reflect the communities we serve. committed to creating amore diverse staff to improve about race andequality. With thisrenewed focus, we are uncomfortable conversations at MemorialSloanKettering The seismicevents of2020sparked honest, sometimes AND INCLUSION AT MSK ON EQUALITY, DIVERSITY, PERSPECTIVES PERSONAL

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CHANGE 52 a license orcertification. requirements from alljobsunless required for made thecommitment to remove educational requirement. Andinthesummerof2020,we to MSK.Over time, we started removing the could have madeameaningfulcontribution which endedupeliminating many peoplewho however, that thiscreated anartificialbarrier, college degree to reach top talent.We found, practice to addeducation requirements like a many peoplewere unemployed, itwas abest example, duringthe2008recession, whenso attracting andretaining employees. For to closethosegaps,aswell. also have to lookat ourworkforce andwork representation inourpatients; however, we and inclusion.We are focused onincreasing and energy onissues ofequality, diversity, dramatic shiftintheorganization’s attention listened inthepast. Ithinkthere’s beena listen to issues inways that maybe they hadn’t from ouremployees. They took thetimeto there was muchfor themto learnandhear leadership, includingtheBoard, recognized has to feel welcomed andsupported. In2020, feel welcomed andsupported, ourworkforce “In order for ourpatients —allpatients —to CHIEF DIVERSITYOFFICER VICE PRESIDENTOFTALENT ACQUISITION &MOBILITY TOMYA WATT My primaryfocus is ourworkforce — is everyone’s responsibility.” Ultimately, equality, diversity, andinclusion they are thesameasordifferent from me? every day andvalue my colleagues, whether about theindividual.How do Icome to work “It’s muchless aboutprograms andmore — Tomya Watt, Vice President ofTalent Acquisition & Mobility accountable for creating asenseofinclusion.” and inclusionholdingeachotherMSK fulfilling our commitments to equality, diversity, is everyone’s responsibility. me? Ultimately, equality, diversity, andinclusion whether they are thesameasordifferent from to work every day andvalue my colleagues, and more abouttheindividual. How doIcome language. Butit’s muchless aboutprograms to setthefoundation andgive usacommon to provide workshops andlearningprograms Group. We have provided andwillcontinue & Inclusion(ED&I)Council andtheGovernance feel respected, supported, andwelcomed. words, equity—to make sure that allemployees use different tools andsolutions—inother on inclusion.Infocusing oninclusion,we will quota-driven solution.Instead, we have to focus focus ondiversity, itcanbeperceived asa places we’ve drawn from inthepast. attracting talentnotnecessarily from the break down barriersto employment by to develop theircareers here at MSKand existing employees withthebest opportunities Together, we allplay animportantrole in We established theMSKEquality, Diversity However, Iwant to beclearthat ifwe only Additionally, we have to provide our and ChiefDiversity Officer

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CHANGE 54 DIVERSITY INITIATIVES, SLOAN KETTERINGINSTITUTE ASSOCIATE DIRECTOR, OFFICEOFPOSTDOCTORAL AFFAIRS &TRAINEE YAIHARA FORTIS SANTIAGO the uniquecontributions offaculty from different thanthemajorityof researchers. sometimes marginalized orcome from communities We needto hearideasfrom peoplewhoare ideas, backgrounds, andopinionsat thetable. cancer andbiology, we needadiversity of with innovative ways to solve questions about education mightbeshortsighted. To come up qualifications, givingtheedge to anIvy League prestige oftheinstitutions where they studied. weight onthingsthat are subjective, like the as astudent orresearcher, we tend to put when we are considering peoplefor aposition unconscious bias.For instance, inthesciences, “Change requires recognizing your own We alsoneedto recognize someof But whentwo candidates have similar reactions are constructive instead ofdefensive.” and saying, ‘How canIdobetter?’ Andpeople’s summer of2020.People are raising theirhands after thesocialjustice movements inthe unlearning oldways ofthinking,particularly happening at MSK—many peopleseemto be recognize theircontributions andreward them. do isfocus ontheirscience. We needto better moving uptheladderbecauseallthey have to effort onthoseinitiatives, theirwhite peersare at acost. While they are spendingtimeand on projects to helpdiversity. Butthat comes their timeandenergy to mentor themandtake generation coming after them.They sacrifice are committed to openingthedoorsfor the underrepresented populations. Most ofthem Overall, Iamhopefulaboutwhat’s underrepresented backgrounds whomay in thelast ten years to helppeoplefrom affordable for abroader demographic ofpatients. strategies to make thesetreatments more underrepresented populations andfinding access to care for peoplefrom diverse and of themainissues inmy fieldare addressing cellular therapy, like CAR Tcell therapy. Some focuses onadultbonemarrow transplant and the issues that still remain inthiscountry. these topics andinunderstanding someof though othershave been really interested in the first timesin my life where itseemedas been present. Ithinkthat 2020was oneof can remember, issues ofrace have always divided by railroad tracks. For aslongI in theSouth,atown that’s still inlarge part “I’m ofAfro-Caribbean heritageandIgrew up HEMATOLOGIC ONCOLOGIST MELODY SMITH Medically, we’ve madealotofadvances I’m aphysician-scientist whosework that needsto bemade.” and at MSK.Butthere’s still alotofprogress changed intheyears since, bothinthecountry its 60thanniversary in2020.Somuchhas restaurants andbusinesses. Their sit-in marked helped leadto themovement that integrated Woolworth’s lunchcounter onFebruary 1,1960, one oftheGreensboro Four, whosesit-inat a One ofmy cousins onmy sideis mother’s that it requires persistence andcantake time. who are Black,Latinx, andotherpeople ofcolor. outcomes between white patients andthose many factors that fuelthedisparityincancer cost oftheselifesaving therapies. That’s oneof not have access to insurance that willcover the many peoplefrom thesebackgrounds may bone marrow transplant. Butunfortunately, not have many matches ondonorlists for a I’m hopefulaboutchange. ButIalsoknow

5553 Annual Report 2020

CHANGE 54 56 trials, to patient care, andto carryingoutthe crucial to discoveries inourlabsandclinical and clinicaltrainees, andthework they dois backgrounds. MSKhasover 3,000 scientific we attract more trainees from diverse feel included andvalued. a culture where peoplefrom allbackgrounds on every level. Just asimportantiscreating diversify thepeoplewhowalk inourhallways, colleagues have raised theirhandsto help racial issues, it’s gratifying to seehow many and theheightened consciousness about “After theevents inthesummerof2020, VICE PRESIDENT, SCIENTIFICEDUCATION &TRAINING USHMA NEILL In my field,onepriorityismakingsure we shouldreflect that.” “We live inthemost diverse area intheworld — — UshmaNeill,Vice President, Scientific Education & Training reflect that.” most diverse area intheworld —we should into New York Cityclassrooms. We live inthe also sendourtrainees asscience ambassadors school andcollege training programs. We underrepresented backgrounds inourhigh We are actively seekingparticipantsfrom until peopleapplyto MSK’s graduate programs. evaluate candidates. Andwe’re notwaiting the last few years andrevisited theway we to includeamore diverse mixofschoolsover will form thenext generation ofMSK. MSK mission. Trainees are thebackboneand We’ve broadened ourrecruitment efforts

57 Annual Report 2020

CHANGE 58 that whenwe have diverse, localsupplierswe our employees andpatients. MSKalsoknows to continue thisfocus in2021andbeyond. commitment intensified in2020. We are eager LGBTQ vendors, andothergroups. Andthat owned by women, minorities,veterans, group ofsuppliers,includingcompanies MSK hasmadeitafocus to attract adiverse companies. Butover thelast several years, and it’s easy to gowiththebig,established tremendous amountofindividualsupplies, “As ahealthcare provider, MSKpurchases a SUSTAINING CARESERVICES SENIOR VICEPRESIDENTOFSUPPLY CHAINAND KREG KOFORD MSK feels our suppliersshouldreflect and for thecommunities we live in.” healthcare suppliersisgood for us,for them, often very nimble, andhelpingthembecome quickly to producing PPE.These companies are local, diverse supplierswere ableto transition when COVID-19 first hit, we found that some benefits in terms ofinnovation. For example, develop thecapacityto become oursuppliers. to partnerwithlocalcompanies to helpthem communities we live in.So, we are reaching out help strengthen theeconomic healthofthe Mentoring companies canhave real are negative experiences. Feeling safe and than theirwhite counterparts —many ofwhich are likely to have more interactions withpolice nothing was found. Statistically, peopleofcolor searched for drugs andthenletgowhen over onmy college campusafew times and where MSKcanalsoplay arole. Iwas pulled rest oflife too. That’s alarger systemic issue can’t beonlyat work. Ithasto extend to the succeed —itshouldbenormal,notexceptional. People needto seepeoplelike themselves worldviews are accepted andrespected. feel comfortable andfeel theircultures and people whoare currently underrepresented effort to recruit andimprove diversity so MSK ismakingafocused andintentional you. The solutionsare notsimple. ButIthink you seeless andless peoplewholooklike stage. At eachstage, asadiverse person, phase between thepostdoctoral andfaculty “As aresearch fellow, I’minthetransition Also pictured onpage43 RESEARCH FELLOW, SLOAN KETTERINGINSTITUTE CORNELIUS TAABAZUING That feeling ofbeingaccepted andsafe ten, 15years from now?’” forward andsay, ‘What dowe want itto belike to thinkofcreative solutionsandthenproject is incredibly smart.Usethoseincredible minds problem. ‘How canIsolve it?’ Everybody at MSK take ownership. Think ofdiversity asyour own and societyoverall. that permit racism. This willhelptheinstitutions work together andchangegovernment policies really want to make adifference, they need to like MSK,Columbia, Harvard, NYU, andothers doesn’t agree withyour views? Butifinstitutions do you risklosingphilanthropic supportthat inclusive. Taking astance like that isarisk— and laws that tryto make ourcountry more in, thisisourstance,’ andsupportpoliticians MSK publiclysay, ‘Look, thisiswhat we believe that way insidework too. respected outsideofwork isvitalto feeling At anindividuallevel, Isuggest people It’s importantto have institutions like

57 59 Annual Report 2020

CHANGE 60 our own worldview basedonourexperiences, And it’s notnecessarily intuitive. We allhave where ourpatients are coming from. sensitivity andcompetency to understand of patients butalsothat we have thecultural making sure that we care for awidediversity feel valued andheard. The second isnotonly it’s diverse andthat peoplewhowork at MSK buckets. Oneisourworkforce andmakingsure “In my field, we are working ontwo big CHAIR, GRADUATE MEDICALEDUCATION COMMITTEE INFECTIOUS DISEASE PHYSICIAN MONIKA SHAH That’s really importantincaringfor people. reflected inourfuture faculty.” and more culturally aware willdefinitely be active steps to make ourtrainees more diverse physicians were trained here at MSK,sotaking in theseissues. Nearly50percent ofour training. Andwe are expanding ourtraining and understanding ofotherpeoplethrough different from us. truly understand someonewhomay bevery and itsometimesrequires active thinkingto We know we canimprove oursensitivity that drive equality, diversity, andinclusion. our leadersunderstand theissues andbehaviors as amemberoftheED&ICouncil, whichhelps Kettering. I’mfortunate to have beenappointed patient populations coming to Memorial Sloan making sure ourstaff mirrors thediverse too. Asaleaderofcolor, Iam proof. We’re diverse, ouremployee baseshouldreflect that, that we don’tloseoursenseofhumanity. is for ourstaff. The most importantaspectis do itisjust asimportantfor ourpatients asit It’s atwo-way street: What we doandhow we leadership whenwe fall shortonexpectations. every patient encounter andsummarize for needs ofourpatient community. Ilearnfrom offerings to ensure that we are meetingthe interpretation services, andpatient recreation advocate. Ialsooversee ourinformation desk, with patients andtheircaregivers asan “I have theprivilegeofworking directly HOSPITAL ADMINISTRATION VICE PRESIDENT, PATIENT RELATIONS JORGE CAPOTE As ourpatient population becomes more senior leadership. To me, that isvery reassuring. less —there’s avery strong commitment from institution —at theheightofapandemic,no look at thespeed ofimplementation from the It’s notgoingto happenovernight, butifyou are paramount to fixingtheissues together. Greater transparency andfrank conversations better path now. We’re onapath ofawareness. of theproblem. behaviors we’ve condoned inthepast was part This isagamechanger. Notrealizing what employees onequality, diversity, andinclusion. We’re alsousinganew moduleto properly train denouncing racism andotheruncivilbehaviors. example, MSKrecently passed apolicy formally employees onbuildingbetter relationships. For We have challenges,sure, butwe’re ona We’re makingadedicated effort to educate ”

61 Annual Report 2020 2020 IN Review

MSK Giving Donors to Memorial Sloan Kettering Boards of Trustees and Governing Trustees Leadership Statistical Profile Financial Summary The Society of Memorial Sloan Kettering

A Scrabble message (left) in the Charles Hallac Patient Recreation Center helped keep MSK's healthcare heroes' spirits lifted.

MSK GIVING MSK 64 continue to make success stories like Rihanna’s possible. Three-year-old Rihanna(above) received agroundbreaking targeted therapy aspartofaclinicaltrialat MSK.Our generous donors Giving MSK and education worldwide.” care ofourpatients andadvancing cancer research remain 100percent focused on ourmission —taking Sloan Kettering’s donorcommunity allowed usto “In thisextraordinary year, thegenerosity ofMemorial 2020 — LisaDeAngelis,Physician-in-Chief andChiefMedicalOfficer • PPEandothercriticalsupplies • Recognition andresearch opportunitiesfor nurses • Greater access to care through telemedicine • Food andfinancialassistance for patients inneed philanthropy supported: •  •  •  by launching: philanthropy helpedusexpand access to ourtraining programs and diverse leadersinoncology research andcare. This year, MSK iscommitted to growing thenext generation oftalented Education • Anew framework for understanding metastasis • The launchofMSK’s Office ofHealth Equity • 230COVID-19-related research papers • FDA approvals oflife-changing treatments people withcancer . In2020, MSKdonorshelpedmake possible: trials, whichleadto new drugsandbetter outcomes for Philanthropy isessential to early-stage research andclinical Research high prioritiesandembrace opportunitiesasthey arise. In2020, to thepandemic.Unrestricted giftsallow MSKto swiftly address community helpedourdoctors andnursesseamlessly adapt Patient care isat theheartofMSK’s mission, andthedonor Patient Care andGreatest Needs New programs andfellowships for women inscience and Technology Initiative The MaximizingExcellence inResearch, Innovation, Academic Careers inCancer Research The Diversity ClinicalScientist Fellowships for

65 Annual Report 2020

MSK DONORS MSK 66 Moment Met the HOW MSKDONORS families worldwide. Scan here to learn more andto donate. to advance cancer care, research, andeducation. $309,547,924 families, foundations, andcompanies donations from 507,000 715,000 individuals, nearly received MSK 2020, In and generosity ofsomany. Thank you to everyone who events online, andwe are grateful for theexceptional commitment support oneanotherandourinstitution, suchasmoving meetingsand Facing unprecedented challenges,ourcommunity reimagined how to to drive progress and bring hopeto peoplewithcancer andtheir who contributed atotal of came together IN 2020 more donations. donors madetwo or 90,000 THAN MORE their giving. donors increased 65,000 MORE THAN fundraisers for MSK. Facebook andInstagram 1,329 DONORS HELD and 41Board members,contributed 3,000-plus donors,includingalmost 750MSKstaff $6.3 million to theMSKCOVID-19 Fundto supportourpatients andstaff. Memorial Hospitalandonline. which were displayed at to MSK’s healthcare heroes, “Words ofEncouragement” donors submitted heartfelt 2,000 More than

121,866 first onlinedonation. donors madetheir

their estate plans. that MSKwas in people told us 415

67 Annual Report 2020

DONATIONS 68 MSK William Randolph Hearst for Fund Goodman Mitchell Alan and Sandra Gerry Susan and Ronald Frankel Foss Family Foundation Israel Englander DeMian M. Trust Florence of Davis/ Andrew and Kate Breast Cancer Research and Trust Herbert of Madeline and Alan Blinder S. Anonymous $1,000,000–$2,499,999 Zeisel Trust Stanford of The Starr Foundation To Up Cancer Stand Foundation JPB The $2,500,000–$4,999,999 Jamie Nicholls and Donald and Catherine Marron Marie-Josée and Kravis Henry Crimson Lion/Lavine Family Black Leon and Debra Across Science Aligning $5,000,000–$9,999,999 F. Fiona and Stanley $10,000,000–$19,999,999 Estate of Emil J. Vaccari J. Emil of Estate Family Thompson The GIFTS OF$100,000 ANDABOVE DONORS TO Foundations Research Sarcoma Charitable Fund Davis Cullom Shelby The Foundation Anneliese Bodenheim Charitable Trust Foundation Initiative for Parkinson’s Research) Fox Foundation J. Michael Parkinson’s (with The Druckenmiller Foundation Fran Biondi

The Judy and Fred Wilpon Wilpon Fred and Judy The Wien Anita and Byron Ullrich L. Trust Elaine of Inc. Companies, &Shop Stop Richard Serra and Clara The Seidenberg Family Cancer Runyon Damon Jack Rudin Family Foundation Rometty Virginia and Mark Cancer for Institute Parker Ovarian Cancer Research Metropoulos Family for Foundation Mark The Lynch J. Trust Patrick of and MD, Klimstra, S. David Jr. Kleberg, J. Robert Family Kelly &Joelle Brian Mr. and Mrs. John John Mrs. Mr. and Bissell Trust Georgina of Bhusri Aneel Benevity Community Impact Band of Parents Foundation W. Backer Eleanor of Estate Anonymous Foundation Allen Rita The $500,000–$999,999 Jack and Dorothy Byrne Fund Wellcome Burroughs in Family Blessing The Family Foundation Weyergraf-Serra Foundation, Inc. Research Foundation Immunotherapy Alliance Foundation Cancer Research MD Klimstra, A. Sibel Foundation Kleberg C. Helen and Foundation Fund Foundation Blessing Keith Carrie of Memory Jr. Blackman, N.

The G. Harold and Leila Leila and Harold G. The Martello John Mrs. Mr. and Kushner Lee and Murray Stephanie and Ken Karl JPMorgan Chase Helman Trust Gilbert of Steven Greenberg A. Goldman Sachs & Company Fehl Gertrude of Estate Edward P. Evans Foundation Equinox Elizabeth Freitag Dranoff Danon R. Howard of Estate Dalton M. Joyce of Estate Sharon Levine Corzine Peter, Jane, and Douglas Chetkin Dr. of David Estate The Applebaum Antidote Health Foundation Anonymous $250,000–$499,999 The Bank of America America of Bank The Varma Rachel and Somit Tropp Ruth of Estate Teich K. Trust Phyllis of Taussig R. Trust Andrew of Stuart G. Lisa and M. Scott Straub Trust Erik of Foundation Singer E. Paul Sephora Prostate Cancer Foundation Paley Carol Janet of Estate York New Community The Miller J. Trust Larry of Melanoma Research Alliance Thomas Mrs. Mr. and Charitable Trust Angiosarcoma for Fund Memorial Cohen for Cure of Cancer of Cure for Charitable Gift Fund Foundation, Inc. Trust E. McInerney Foundation Y. Mathers

Trust of Jack and and Trust Jack of HealthCorps F. Edwin of Hantman Estate Susan Zises Green Gomich Mary of Estate Gilead Sciences, Inc. Fitzpatrick S. Trust Robert of Feil Trust Louis of Expect Miracles Foundation Sydney Engel Dermody J. Patricia of Estate Dennell K. James of Estate Barbara Dauphin-Duthuit A. Dalton Family Foundation Cooper Ann Trust Joy of W. Conley Trust Marie of Cancer vs Comedy Clark B. &Alice James A. Charina Endowment Fund Family Castellano The Couch Cancer The Lou Mary Trust Captain of Sohn Conference Foundation The Rosanne H. Silbermann Stephanie and Fred Shuman Claire-Marie of Estate The Rose-Margulies Fund Family Robbins The Markets Capital RBC Posner Bernard of Estate Wiedmann Dorothy of Estate Noonan Jane Mary of Estate Foundation Niarchos Stavros Neuroendocrine Tumor Francois Wallace Monahan Milton Jim Meyers M. Howard Mathias Faith of Estate Manning A. Trust Estelle of Maggie’s Mission LUNGevity Foundation Linn Family V. Leonowich Daniel of Estate Lawrence A. Trust Philip of The Ralph Lauren Corporate Larson Matthew The Langen Annie of Estate ICAP Megan MacDonald Hodgson Hilton N. Conrad The Foundation Foundation Calene Foundation Scheffbuch Foundation Nowak Research Foundation Fund Foundation Foundation Foundation Hersh Sabine

In Loving Memory of of Memory Loving In Cantor C. Samuel The Group Performance Brown Foundation Brook Brothers Cancer Breast Terri Brodeur Breed John and Kerry Breast Cancer Alliance, Inc. Brave Like Gabe Foundation The Bondi Foundation Inc. Foundation, Blum C. Edith Bloomberg Trust of Hannah Blank Blackstone Charitable Beznos Harold Mrs. Mr. and Herbert and Frances Berkowitz Bernard of Estate Berg Irma of Estate Foundation Street Baker The Anonymous Lung Association American American Diabetes &Company Allen Foundation Family Allen The Allen D. Christopher and Kate MD/ Abramson, H. David AbbVie Away Cancer Walk 3K $100,000–$249,999 Connecticut Cancer Community Foundation of Comins L. Trust Barbara of Eve Colin and Simon Coleman J. Paul Cole Rose And Ben The Clark Neil and Argero Cigna Foundation The Cholangiocarcinoma Chan Zuckerberg Initiative Sai and Lucy Chan Cassagne J. Renee of Estate Samuel Waxman Cancer Watters Jean Trust E. of Wanger Anthony and Alyse Cancer for V Foundation The Tiller J. Trust Dr. of Hans Inc. America, Across Swim Steinhardt Elinor of Estate Charitable Trust Foundation Foundation Bernstein Association Knowledge, Inc. Ophthalmic for Fund The Foundation Tompkins County Foundation Charitable Pria Foundation Foundation Kenneth Carmel Research Foundation Research

The Louis V. Gerstner Galaid C. Ruth of Estate Gabrielle’s Angel Foundation Fund Fuller Anna The The Stephen and Barbara Mark and Mary-Anne Franklin Franco L. Sandra of Estate Fleisher S. Ruth of Estate First Eagle Investment P. Farrington Trust Harold of Fanjul Pepe J. Mrs. Mr. and Fanjul Alfonso Mrs. Mr. and Epstein David and Geri Mildred and Trust Garrett of Trust of James Douglas Dorney Richard of Estate Andree Wildenstein Lou and Debi Dobbs Cummins C. Trust Carrie of Cronin Lou Mary of Estate Group Suisse Credit Y. Edith of Crafton Estate Cancer Kids’ for Cookies Ian and Patricia Cook Estate of Evelyn Jourdan Evelyn of Estate Trust of Leonard Josephson F. Jezek Trust Julius of Foundation Jaffe Rona The Jaffe Trust Edythe of Trust George of Hogan R. Richard Foundation Hoch Catie and Y.C. Ho/Helen The Hicks B. Trust Barbara of Henkle J. Trust Norma of Stefanie and Jay Heleva, Hearst Hearst Gillian Trust Deborah of and III, W. Hamilton, Lawson Andreas and Diane Halvorsen Orland and S. Frances York New Hospital Greater Grayson Josephine and Peter Gray Foundation Graham J. Sally David of Memory In for Cancer Research Cancer for Friedman Foundation Management Eelman Foundation Dormeuil & Roger Dormeuil T. Hohenboken Michael Chiang Foundation Group Media Seen Hanson-Murphy Frances Hamilton Fund Greene S. Association J. Goyette Inc. Jr. Foundation,

Trust of Joan M. Phillips M. Trust Joan of Charitable The Dina Perry Trust of Elizabeth L. Perkins L. Trust Elizabeth of Peiz Katinka Sven and The PaulieStrong Parnes Francine Parnes/The Action Cancer Pancreatic Ltd. Assets Palombo Group Olayan The and Norris Arden The Reba of Memory In Richard Nerod National Breast Cancer Nagy Edward of Estate Mushett Family Family Mushett Modell M. Leslie Millar A. Trust Barbara of Peter Michael Foundation Marie-Noelle Meyer Foundation MetLife Meridian Foundation Melanoma Research MDS Foundation McGowan Robert of Estate Alan McConnell G. Matlin Lori and Howard The Maloris Foundation John Magnier Lynn Schulz Trust Ella of Group LVMH Fashion The Lustgarten Foundation Ludwig R. Trust Bert of Foundation Life of Light The Eric and Levine Amy The Lerner Foundation Leonard K. Trust Janet of T.Trust Ethel of Larus LaRose Dorothy of Estate Sheila and Bill Lambert Fay Lamb Trust Grace of Kret J. Kenneth Kreimer Mary of Estate NYC Greater Komen G. Susan Maxine and Edward Margaret Keane M. Miriam and Trust Henry of Fund Foundation, Inc. Family Network Foundation Witherwax Cecelia Mary Newman K. Foundation Foundation, Inc. Foundation Americas, Inc. Research Cancer Pancreatic for Gronningsater Kerschner Kaplan

Jules L. Plangere, Jr., Jr., Plangere, L. Jules Estate of Pauline Zonon Pauline of Estate Robert and Jacqueline Peter and A. Deborah Nicolaus and Christiane Walter R. Trust Flora of Waletzky R. Dr. Lucy Waddock Marilyn of Estate Inc. Fund, Projects Vital Foundation Vanover Steven Leon Devere of Estate Turner G. Trust Sanford of Tudor Investment Thomas Tryforos N. T. Thomas Sunil W. Thatcher John of Estate TeamConnor Cancer James Tanenbaum R. and Taft Foundation The Szalkowski A. Ervin of Estate Street Valerie and Paul Squiers Virginia B. forSportsmen Charity, Inc. Sorrell JMCMRJ The Peter and Susan Solomon Yuriy Shteinbuk and Shine Trust Carolyn of The Shen Family Foundation Serra-Blanco Anita of Estate &Samuel Beatrice The Schwalie Lawrence of Estate Schlosstein-Hartley Family Susan and Stephen Scherr F. Scheich Trust John of Morris Alma and Schapiro Andrew Sabin Family Ruppert A. Barbara of Estate The Laura Rosenberg V. Peter of Robilotta Estate The Robertson Foundation V. Reich Constance of Estate Jr. Rea Frank of Estate Rally Foundation II Price M. Virgil Porter Gary and Cynthia Willens Foundation WeinbergL. Family Weickart Vandervort Corporation Foundation Scofield M. Elizabeth Foundation Foundation Elizabeth Mead SeaverA. Foundation Foundation Fund Foundation Foundation Inc. Family Foundation

69 Annual Report 2020

MSK BOARD MSK 70 * + the passing of Paul A. Marks and Elizabeth J. McCormack. Elizabeth and Marks A. of Paul passing the sadness with note community Kettering Sloan Memorial the and Trustees Governing and of Trustees Boards * The officio + ex CONSULTANTS SCIENTIFIC OF BOARD MD Marks, A. Paul W.James Kinnear Peter O. Crisp EMERITI TRUSTEES OF BOARD Treasurer ROBBINS S. CLIFTON Hospital Memorial Trustees, of Governing Board Chair, and of Boards Chair Vice NICHOLLS C. JAMIE Institute Kettering Sloan Trustees, Governing of Board Chair, and of Boards Chair Vice KRAVISMARIE-JOSÉE Chair STUART M. SCOTT 2020 31, DECEMBER OF AS TRUSTEES GOVERNING AND BOARDS TRUSTEES OF James R. Downing, MD Downing, R. James PhD de Lange, Titia MD Davidson, E. Nancy Cooney, MD Kathleen PhD MD, Cole, A. Philip MD Axel, Richard MD Applebaum, R. Frederick Louis V. Gerstner, Jr. V. Gerstner, Louis V.Ellen Futter Friedman Stephen Foster, N. PhD Richard Ford E. William ForbesSteve Flatt Bruce Fernandez A. Henry Roger W. Jr. Ferguson, PhD Evnin, B. Anthony F.Stanley Druckenmiller Cook M. Ian Canada Geoffrey John J. Byrne Mrs. Bhusri Aneel Beattie I. Richard Allen Kate

* Fayez Sarofim S. Rosen M. Benjamin PhD J. McCormack, Elizabeth Olufunmilayo Olopade, MD Olopade, Olufunmilayo PhD MD, Lifton, Richard PhD Levinson, Arthur PhD Hannon, Gregory MD Goldstein, Joseph L. PhD MD, Gillison, L. Maura PhD MD, Garraway, A. Levi James D. Robinson III D. Robinson James T. Robertson Alexander Robbins S. Clifton Ratner C. Bruce Olayan S. Hutham O.Adebayo Ogunlesi Och S. Daniel Nooyi K. Indra Niven G. James Nicholls C. Jamie Martin Kathryn Marie-Josée Kravis Keane M. Margaret William Helman Jr. W. Heineman, Benjamin D.Jane Hartley Grayer N. Jonathan Chief Executive Officer and President MD THOMPSON, B. CRAIG Hospital Memorial Board, of the Chair Honorary BEATTIE I. RICHARD Institute Kettering Sloan Board, of the Chair Honorary JR. V. GERSTNER, LOUIS Chair Honorary III WARNER A. DOUGLAS Irving L. Weissman, MD Weissman, L. Irving Weissleder,Ralph PhD MD, PhD Shokat, Kevan PhD Rothman, E. James PhD MD, Ribas, Antoni Regev,Aviv PhD Mortimer B. Zuckerman B. Mortimer Winkelried Jon Weinberg A. Peter III Warner A. Douglas MD Waletzky, R. Lucy MD F.David Torchiana, MD Thompson, B. Craig Stuart M. Scott Strangfeld R. John J. Squeri Stephen Peter J. Solomon Sherrill C. Stephen Selby C. Norman D. Schnitzer Alan Sanders A. Lewis Rubenstein M. David Rometty M. Virginia

AS OF DECEMBER 31, 2020 31, DECEMBER OF AS SCIENCES GRADUATE MEDICAL OF SCHOOL CORNELL WEILL DIVISION SLOAN KETTERING Assistant Treasurer MARK SVENNINGSON Treasurer KATHRYN MARTIN Provost P MASSAGUÉ, JOAN Board of the Chairman JR. V. GERSTNER, LOUIS 2020 31, DECEMBER OF AS CENTER CANCER SLOAN KETTERING MEMORIAL SCIENCES GRADUATE BIOMEDICAL OF JR. SCHOOL V.LOUIS GERSTNER, Marie-Josée Kravis Jr. V. Gerstner, Louis V.Ellen Futter Beattie I. Richard TRUSTEES Molecular Biology Unit Biology Molecular KOFF, P ANDREW Unit Biology Structural Biochemistry and LIMA, P LIMA, D. CHRISTOPHER CO-CHAIRS PROGRAM GRADUATE Director P MASSAGUÉ, JOAN h D h D h

h D D Pharmacology Unit Pharmacology P MD, DAVID SCHEINBERG, A. Biology Unit Developmental and Cell P HELIN, KRISTIAN Education and Training and Education Scientific President, Vice USHMA NEILL, P NEILL, USHMA Secretary ESQ. LEVINE, CAROLYN B. Dean OVERHOLTZER, P MICHAEL President MD THOMPSON, B. CRAIG Douglas A. Warner III Warner A. Douglas MD Thompson, B. Craig Stuart M. Scott D. Schnitzer Alan h D h D h h D D

Chief Risk Officer Risk Chief ESQ. BURNS, DEBRA Associate Dean Associate D. BURNLEY LINDA Pathogenesis UnitPathogenesis Microbial and Immunology RUDENSKY, P Y.ALEXANDER h D

71 Annual Report 2020

MSK LEADERSHIP MSK 72 Hospital Administration President, Vice Senior JUDY HAGERTY-PAGLIA Hospital Administrator and President Vice Executive GROVES NED Hospital Administration President, Vice Senior FAHY ROSANNA Planning Financial President, Vice Senior ANTHONY DIASIO Management Technology and Research President, Vice Senior ERIC COTTINGTON, P COTTINGTON, ERIC Operations Financial President, Vice Senior ANKIT CHHABRA Operations Partnership President, Vice Senior BURKE MARGARET M. Chief Human Resources Officer and President Vice Senior KERRY BESSEY Officer Risk Chief and President Vice Senior ESQ. BERNS, DEBRA Officer HealthChief Equity and President Vice Senior MD BROWN, CAROL Director, International Center and International Programs President, Vice Senior MD F.MURRAY BRENNAN, Nursing Officer Chief and President Vice Senior CENP RN, MSN, MCCORMICK, N. ELIZABETH Memorial MedicalChief Officer, and Physician-in-Chief MD DEANGELIS, LISA Chief Executive Officer and President MD THOMPSON, B. CRAIG 2020 31, DECEMBER OF AS CENTER CANCER SLOAN KETTERING MEMORIAL LEADERSHIP Hospital

h D Vice President and Controller and President Vice MALARKEY KEVIN Construction Management and Facilities President, Vice Senior EDWARD J. MAHONEY Counsel General and President Vice Executive ESQ. JR., LOPEZ, JORGE Corporate Secretary and Counsel General Deputy ESQ. LEVINE, CAROLYN B. Services Care Sustaining and Chain Supply President, Vice Senior KREG KOFORD Officer Investment Chief and President Vice Senior JASON KLEIN Chief Digital Officer CLAUS JENSEN Officer Financial Chief and President Vice Executive HARRINGTON MICHAEL Partnerships Strategic President, Vice Senior T.JAMES HARDEN Clinical Research Physician-in-Chief, Deputy MD PAUL SABBATINI, Partnerships Strategic Physician-in-Chief, Deputy MD CAHLON, OREN Center Breast Lauder H. Evelyn Medical and Director, President the of Office President, Vice Senior MD NORTON, LARRY Institute Kettering Director, Sloan P MASSAGUÉ, JOAN Officer Operating Chief KATHRYN MARTIN h D Chief Diversity Officer TOMYA WATT Officer &Communications Marketing Chief and President Vice Senior ROXANNE TAYLOR Finance President, Vice Senior MARK SVENNINGSON Administration Institute Kettering Sloan President, Vice SLATTERY A. CAROL Officer Information Chief and President Vice Senior ATEFEH RIAZI Relations Provider and Managed Care President, Vice Senior MARK RADZYNER Innovation Planning and Strategic President, Vice Senior WENDY PERCHICK Hospital Administration President, Vice Senior MCCOLLUM CYNTHIA Officer Development Chief and President Vice Senior MANOTTI KENNETH Core Technologies Institute Kettering Sloan Director,Deputy ROBERT BENEZRA, P BENEZRA, ROBERT Officer HealthChief Informatics and Physician-in-Chief Deputy MA MD, STETSON, PETER Safety and Quality Physician-in-Chief, Deputy MD SEPKOWITZ, KENT

h D

Structural Biology Structural P LIMA, CHRISTOPHER Pediatrics P MD, KUNG, ANDREW Pathology MD DAVID KLIMSTRA, S. Medicine MD KANTOFF, PHILIP Radiology P MD, HRICAK, HEDVIG Biology Cell P HELIN, KRISTIAN Biology Developmental HADJANTONAKIS,ANNA-KATERINA P Care &Critical Anesthesiology MD FISCHER, GREGORY Surgery JEFFREY DREBIN, MD, P MD, DREBIN, JEFFREY Physics Medical P O.DEASY, JOSEPH Sciences Behavioral and Psychiatry MD BREITBART, S. WILLIAM Biostatistics & Epidemiology P BEGG, COLIN 2020 31, DECEMBER OF AS CENTER CANCER SLOAN KETTERING MEMORIAL CHAIRS DEPARTMENT AND PROGRAM h D h D

h D h h h D D h D D h D

Chemical Biology TAN, P DEREK Neurosurgery VIVIANE TABAR, MD Pharmacology Molecular P MD, DAVID SCHEINBERG, A. &Pathogenesis Human Oncology MD SAWYERS, L. CHARLES Immunology P Y. RUDENSKY, ALEXANDER Radiation Oncology SIMON N. POWELL, MD, P MD, POWELL, N. SIMON Biology Molecular JOHN PETRINI, P Medicine Laboratory P MD, PESSIN, S. MELISSA Biology Systems & Computational SCOTT W. LOWE, P W.SCOTT LOWE, DANA PE’ER, P PE’ER, DANA Neurology INGO MELLINGHOFF, K. MD Nursing CENP RN, MSN, MCCORMICK, N. ELIZABETH Genetics and Biology Cancer h h D D h D h D h h D D h h D D

73 Annual Report 2020

STATISTICAL PROFILE STATISTICAL 74

(3) (2) Bed Occupancy Rate Average Patient Stay (days) Total Patient Days Total Admissions Patient Admissions: Children Patient Admissions: Adults PATIENT CARE MEMORIAL SLOAN KETTERING CANCER CENTER STATISTICAL PROFILE Outpatient MDVisits: Manhattan Screenings Total Outpatient Visits Outpatient MDVisits: Regional Network 153,451 Clinical Investigation Protocols Radiology Procedures Diagnostic andInterventional Starting Treatment: Regional Network New Radiation Oncology Patients Starting Treatment: Manhattan New Radiation Oncology Patients Surgical Cases (1) Excludes studies closedto accrual Data from 2016 represent individualscreening visits;2017-2020 data represent screening procedures. Data from 2019 have beenrevised. Based onadjusted bedcount (2)

(1) (3) 665,593 498,372 160,072 23,066 25,330 512,142 526,006 23,497 23,078 23,506 21,708 92.5% 94.3% 3,399 2016 4,831 1,370 1,072 6.9 543,322 772,238 776,546 196,232 161,661 31,683 21,953 22,792 5,283 4,434 2017 2018 4,510 5,203 1,553 1,133 1,139 235,400 575,383 541,146 171,798 173,702 160,922 24,243 38,738 45,263 45,549 27,919 95.2% 1,451 1,4221,305 7.1 631,174 591,450 276,849 276,700 839,073 781,924 562,224 505,224 25,597 22,822 27,379 23,967 2019 24,175 21,517 96.2% 85.9% 5,538 4,173 6,616 6,666 1,159 1,254 6.8 7.1 2020

Total Staff Administrative andSupportStaff Registered Nurses Advanced Practice Providers Hospital Attending Staff Sloan Kettering Institute Members STAFF Laboratory MedicineStudents Occupational Therapy Students Physical Therapy Students Radiation Oncology Technology Students 12 Social Work Students Nursing Students Medical Students Medical Observers Registrants inCMEPrograms MD/PhD Candidates PhD Candidates Graduate Research Assistants Research Associates Research Scholars Research Fellows Residents andClinicalFellows: AnnualTotal 1,734 Residents andClinicalFellows: Positions 468 EDUCATION Volunteers

(1) In 2020, 41 staff membersheldappointmentsinboththeInstitute andtheHospital. (1)

15,697 11,638 4,724 6,098 2,259 3,098 2016 1,091 605 344 346 943 1,019 569 563 292 351 131 133 112 20 13 43 26 92 120 8 7 5 6 2 3 12,325 17,301 2017 2018 1,749 1,148 468 623 355 278 266 577 524 511 115 24 37 34 12 18,569 20,559 21,105 3,398 13,137 14,33314,774 7,246 1,228 1,358 1,417 1,714 960 569 596 31 702 836 476 325 346277 130 133137 133 512 595 507 117 132153 22 2021 15 15 6 70 8 64 2019 3,874 3,933 1,690 1,619 7,921 770 432 477 246 475 460 277 282 150 171 39 28 19 12 20 2020 6,582

885

75 Annual Report 2020

FINANCES 76 $ Supporting Operations $ Philanthropic Revenue Supporting Operations Philanthropic Revenue MEMORIAL SLOAN KETTERING CANCER CENTER FINANCIAL SUMMARY $5,407,196 $5,407,196 (Dollars inT 2020 (Dollars inT 2020 $ Revenue $ Patient Ca Revenue Patient Ca 281,616 281,616 4,261,296 4,261,296 $ Supporting Operations $ Philanthropic Revenue Supporting Operations Philanthropic Revenue $5,407,196 $5,407,196 (Dollars inT 2020 (Dollars inT 2020 $ Revenue Patient Ca $ Revenue Patient Ca 281,616 281,616 4,261,296 4,261,296 TOT TOT housands housands re re

AL OPERA AL OPERA TOT TOT housands housands re re

AL OPERA AL OPERA ) ) ) ) TING REVENUES TING REVENUES TING REVENUES TING REVENUES $516,744 Other Income Royalty and $3 C Gr $516,744 Other Income Royalty and $3 C Gr ont ont ants and ants and 47,540 47,540 ra ra $516,744 Other Income Royalty and $3 C Gr $516,744 Other Income Royalty and $3 C Gr ont ont ct ct ants and ants and 47,540 47,540 s s ra ra ct ct s s $103,682 Int $3,184,891 Benefits and Fringe Compensation $103,682 Int $3,184,891 Benefits and Fringe Compensation $5,824,368 $5,824,368 (Dollars inTh 2020 (Dollars inTh 2020 er er es es $103,682 Int $3,184,891 Benefits and Fringe Compensation $103,682 Int $3,184,891 Benefits and Fringe Compensation $5,824,368 $5,824,368 (Dollars inTh 2020 (Dollars inTh 2020 t t TOTA TOTA er er es es ousands ousands t t TOTA TOTA

L OPER L OPER ousands ousands ) )

L OPER L OPER ) ) AT AT ING EXPENSES ING EXPENSES AT AT ING EXPENSES ING EXPENSES $ Amortization $ Depr Amortization Depr $2,123,302 Services Supplies and Pu $2,123,302 Services Supplies and Pu 412,493 412,493 rc rc hased hased eciation an eciation an $ Amortization $ Depr Amortization Depr $2,123,302 Services Supplies and Pu $2,123,302 Services Supplies and Pu 412,493 412,493 rc rc hased hased eciation an eciation an

d d

d d

CAPITAL SPENDING PHILANTHROPIC REVENUE (LOSS) INCOME FROMOPERATIONS Total Operating Expenses Interest Depreciation andAmortization Purchased SuppliesandServices Compensation andFringeBenefits OPERATING EXPENSES Total Operating Revenues Operations Investment EarningsSupporting Royalty andOtherIncome Operations Philanthropic Revenue Supporting Grants andContracts Patient Care Revenue OPERATING REVENUES(inthousands) Net Assets Liabilities Assets BALANCE SHEETSUMMARY $3,954,488 $3,068,587 $3,536,976 $9,891,492 $3,764,651 $2,131,070 5,730,977 1,320,893 $634,134 4,160,515 $189,837 $239,765 $317,270 248,095 263,964 242,934 257,893 296,493 136,979 48,724 2016 $4,409,320 $10,636,012 $10,623,567 $4,169,555 $4,690,794 4,530,909 $2,335,132 $737,965 6,105,103 1,501,935 $318,386 278,643 290,927 159,458 137,750 287,145 300,239 45,343 2017 2018 $4,909,854 $3,973,778 $2,587,336 $2,892,770 $700,827 $219,060 6,427,413 $383,341 $254,401 4,196,154 1,756,174 2,026,254 334,536 159,140 151,473 162,445159,090 47,045 40,099 $628,148 $11,621,453 4,646,113 5,246,709 6,975,340 $5,483,376 $5,288,897 $4,560,174 $4,261,296 $194,479 268,525 281,616 368,743 329,774 123,489 2019 347,540 $(417,172)

$13,315,250 8,068,541 $5,824,368 $5,407,196 $3,184,891 $263,572 $264,706 2,123,302 357,654 103,682 412,493 2020

77 Annual Report 2020

THE SOCIETY THE 78 Society (drugs that stimulate orsuppress theimmune and tested thefirst modernimmunotherapies immunologist JamesAllison.The team developed for ClinicalInvestigation, andNobelPrize-winning Lloyd J. Old/Virginia andDanielK.LudwigChair included medicaloncologist JeddWolchok, the Halpern, whowas partofanMSKcohort that work ofworld-renowned dermatologist Allan philanthropic partnershipincludesupportingthe Recent highlightsofanenormously successful role, servingasaforce for progress at MSK. legacy andcelebrates The Society’s leadership help peoplewithcancer worldwide. to MSK’s abilityto thrive withoutlimitsand Society’s generous givinghasbeenessential have access to life-changing cancer care. The research projects —ensuringthat MSKpatients Kettering hasprovided seedfundingto critical Since 1946,The SocietyofMemorialSloan A Philanthropic Tradition The SocietyCampaign: bringing hopeandreal progress to thosewithcancer.” challenging times.Ourlegacy ofsupportfor MSKendures, of supporters whohave bolstered ourmission duringthese “I amgrateful to themembersofThe Society andournetwork THE OF MEMORIAL SLOAN MEMORIAL OF KETTERING The 2020–2021SocietyCampaignhonorsthat

— Kate Allen,President, The Societyof MSK patients withlate-stage melanoma. system to helpthebodyfightdisease) to treat that particularlyaffect theBlack community. Carol Brown, to address healthcare disparities led by surgeon andChiefHealthEquity Officer Research Program (CHERP), alandmarkinitiative The SocietyfundedtheCancer HealthEquity MSK address challenges to healthequity incancer. optimal nutritionbasedontheircancer diagnoses. need. People receive groceries tailored to provide resource that patients canturnto for acritical regional sites, helpedprovide areliable, no-cost supporting FOOD pantry expansion to MSK’s affect humanhealth. The Society, by thoughtfully Gany, arecognized expert indisparitiesthat (FOOD) Program, ledby internist Francesca MSK’s Food to Overcome Outcome Disparities human needby supportingtheexpansion of The Societystepped forward to meetanessential care isthecornerstone ofThe Society'smission. Supporting standard-setting patient The Societyisalsocommitted to helping

access to no-cost, nutritiousgroceries. Pictured: Community Outreach &HealthAccess supervisor Luke Paolantonio By supportingMSK'sFood to Overcome Outcome DisparitiesProgram, The SocietyofMSKhelpsensure peoplewithcancer have the development ofCARTcell therapy, especially the University ofPennsylvania. Heisapioneerin Medicine at thePerelman SchoolofMedicineat the DepartmentofPathology andLaboratory for Cellular Immunotherapies andaprofessor in Sadelain. Dr. JuneistheDirector oftheCenter June andMSK’s own physician-scientist Michel Sloan Kettering Prize were immunologist Carl The 2020recipients ofThe SocietyofMemorial lasting impactinthefightagainst pediatric cancer. or team leaderwhohasmadeapositive and Academic Convocation to aresearcher, doctor, The SocietyPrize isawarded at theannualMSK Recognizing Achievements Championing Research and life-changing clinicaltrialsat theirown sites. partners withcommunity hospitalsto support underserved people. Through CHERP, MSKnow at localhospitalsandpoorer outcomes for association between high-volume cancer care In herresearch, Dr. Brown hasfound aclear

transgene expression, stem cell engineering, Institute, whichstudies themechanismsgoverning MSK. Dr. Sadelain runsalabat theSloanKettering Director oftheCenter for Cell Engineeringat is theStephen andBarbara FriedmanChairand for pediatric patients with leukemia. Dr. Sadelain awarded to atotal of20postdocs. old. This year, The SocietyScholarsPrize was at MSKwhohave adependentchildunder4years award for upto four years andisopento postdocs its Executive Committee. The prize provides acash from The Society’s President, inconsultation with MSK faculty whoare parents, withfinalapproval They are reviewed by aselectionpanelmadeupof submit abriefapplication andpersonalstatement. awarded annuallyto postdoctoral researchers who to beingnew parents. This merit-basedprize is also managingfamily obligations andadjusting who are performing at thehighest level while against cancer. and geneticstrategies to enhance immunity The SocietyScholarsPrize honorspostdocs l

79 Annual Report 2020 WRITERS Begley Meredith Beth Demel Julie Grisham Emily Kastl Bill Piersol Jim Stallard Tontonoz Matthew CONTRIBUTORS Allison Hale Graham Heather Wu David PHOTOGRAPHY Rick DeWitt Moran Karsten ADDITIONAL PHOTOGRAPHY Fleming Tamara Hildebrand Craig Ethan Kavet Michael Prince PRINTING Allied Printing Services COMMUNICATIONS OFFICER COMMUNICATIONS Taylor Roxanne VICE PRESIDENT STRATEGY & CONTENT EDITORIAL Ami Schmitz EDITORIAL SENIOR DIRECTOR, Sobolik Boyle Katie DIRECTOR CREATIVE Randi Press ART DIRECTOR Glick Kristin EDITOR MANAGING Emily Kastl CHIEF MARKETING & Copyright 2021 Center Cancer Kettering Sloan Memorial ©  PRODUCED BY & Communications Department of Marketing Center Cancer Memorial Sloan Kettering Avenue York 1275 NY 10065 York, New t 212-639-3573 f 212-639-3576

MARCIE PANTZER MARCIE Vice President MRS. M. ANTHONY MAY President Past Mrs. Paul Soros AnnetteDr. Rickel U. Mrs. Bijan Safai Lavinia Branca Snyder Mrs. Richard Perkin T. Betsy Pitts Mrs. Louis Rose Martha Sharp Hope Geier Smith Taube Annie Taube Ferebee Amanda Taylor Mrs. Andrew S. Thomas Victoria Vought Ms. Caryn Zucker Mrs. Bambi Putnam Mrs. Benjamin M. Rosen Mrs. Paul C. Schorr IV Sherrill Kitty Evelyn Angevine Silla Mrs. Smith Sean P. Leith Rutherfurd Talamo Mrs. Michael L. Tarnopol Mrs. Thomas E. Zacharias SHABNAM HENRY Vice President NAOMI WALETZKY NAOMI Treasurer Assistant EGERTON WEBB Secretary Assistant Mrs. Richard S. LeFrak Mrs. Donald B. Marron Linda Gosden Robinson Mrs. Arie L. Kopelman Mrs. Leeds Thomas V. L. Limbocker Derek Mrs. Jean Remmel Little Mrs. Frank A. Metz, Jr. Mrs. Michael Kennedy Martha O’Brien Lamphere Patricia Herrera Lansing Kamie Lightburn Stephanie Loeffler Mrs. Luis José Los Arcos Mrs. Roman Martinez IV McCabe Rebekah Carolina de Neufville Mrs. O’Hara Timothy P. Jennifer Gaffney Oken Palmer O’Sullivan Jones Mrs. Gunnar S Overstrom, III Mrs. Scott C. Johnston Suzie Kovner Mrs. Brian A. McCarthy Mrs. Richard A. Miller Mrs. Minot K. Milliken Mrs. Moss George F. L.Joyce Moss Mrs. Charles H. Mott PryorMrs. Samuel IV F. MRS. CHRISTOPHER CHRISTOPHER MRS. ERRICO Vice President MARIA BOTHMER VON Secretary MRS. MARTHA MRS. MARTHA WEBSTER Treasurer Mrs. Charles A. Dana, Jr. Fiona Druckenmiller Julie Geier Martha Vietor Glass Mrs. S. Peter Gregory Alison Barr Howard Mrs. Jones D. Peter Mrs. Kerryn King Mrs. Jr. Thomas Fahey, J. Forsberg Lars Mrs. Mrs. Thomas M. Fitzgerald III Elizabeth Kirby Fuller Mrs. Stephanie Griswold Mrs. Roberto Guardiola de Mrs. S. John Hilson Melanie Seymour Holland Mrs. Jeffery Ann F. Gretchen Gunlocke Fenton Gunlocke Gretchen Ruth G. Fleischmann Mrs. Robert M. Gardiner Sallie Giordano Mrs. Thomas S. Glover Eugenie Niven Goodman Shoshanna Gruss Alexia Hamm Ryan Leslie Heaney Jennifer James Robyn Lane Joseph Victoria Greenleaf Kempner Kennedy Anna 2020-2021 ADMINISTRATIVE BOARD ADMINISTRATIVE 2020-2021 THE SOCIETYOF MEMORIAL KETTERING SLOAN CANCER CENTER FOUNDER Mrs. Burke Coleman P. Mrs. Edwin M. Burke Mrs. William M. Carson Mrs. B. Walter Delafield Mrs. Bruce A. Gimbel PAST PRESIDENTS PAST PRESIDENT’S COUNCIL PRESIDENT’S Mrs. Araskog Rand V. DixonD. Boardman Conrod Garcia Nina SUSTAINING BOARD SUSTAINING Mrs. Andrew M. Blum Tory Burch Mrs. Michael Carr Nancy Coffey Dianne G. Crary CurtisMrs. James F. III Mrs. James H. Dean Mrs. Hilary Dick Antonia Paepcke DuBrul Travis Acquavella Allison Aston Potter Muffie Aston Mrs. James Halsey Bell Mrs. Alan Blinken J. Carey Catherine Mrs. Kevin C. Coleman Mrs. G. Peter Cordeiro Mrs. Archibald Cox, Jr. Jennifer Creel Mrs. Michael J.A. Darling Mary McDonnell Davidson Kathryn Davis MEMBERS-AT-LARGE KATE ALLEN KATE President EXECUTIVE COMMITTEE EXECUTIVE Mrs. Edward C. Delafield

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80 Annual Report 2020