SACRED HEART COLLEGE (AUTONOMOUS)
DEPARTMENT OF CHEMISTRY
MASTER OF SCIENCE IN APPLIED CHEMISTRY - PHARMACEUTICAL
Course plan Academic Year 2018 - 19 Semester 3
MSC APPLIED CHEMISTRY - PROGRAMME SEMESTER 3 PHARMACEUTICAL COURSE CODE AND 16P3CPHT09: PHARMACEUTICAL CREDIT 4 TITLE CHEMISTRY - I HOURS/WEEK 4 HOURS/SEM 72 DR. JINU GEORGE, DR. GRACE THOMAS, DR. IGNATIOUS FACULTY NAME ABRAHAM, DR. RAMAKRISHNAN S
Course Objectives
To describe the Drug design, Pharmacology, mechanism of action of drugs To interpret the receptor theories and bio-transformation of drugs. To know the structure, synthesis, pharmacological and mechanism of action and SAR of Antiinfective agents. To know the structure, synthesis, pharmacological and mechanism of action and SAR of Drugs acting on CVS To know the structure, synthesis, pharmacological and mechanism of action and SAR of Chemotherapeutic agents To know the structure, synthesis, pharmacological and mechanism of action and SAR of Antipyretics and NSAIDs
LEARNING VALUE SESSION TOPIC REMARKS RESOURCES ADDITIONS MODULE I : Pharmacology (12h) Drugs and Drug targets. Enzymes: active sites, 1 PPT video mechanism of catalysis Enzyme inhibitors, Enzyme selectivity, 2 PPT/Lecture Receptors ligand gated ionic channels G-Protein coupled receptors, Kinase linked 3 PPT/Lecture receptors Carrier Proteins, Structural Proteins, Nucleic 4 acids, Lipids and carbohydrates and DNA as PPT/Lecture e-resource drug targets Structure activity relationship, Binding Q & A 5 PPT/Lecture interactions, Functional groups as binding Session
groups Concept and definition of pharmacophore 6 PPT/Lecture Pharmacokinetic principles: absorption Distribution, metabolism and excretion of 7 Lecture drugs. Dose of drugs and routes of administration. Drug dosing, drug half life, Steady state 8 Lecture concentration, Drug tolerance, Bioavailability, Drug delivery First Internal Examination Pharmacodynamic principles : Examples of 9 agonists, allosteric modulators, Antagonists, Lecture Partial agonists, Inverse agonists Desensitization and sensitization, Tolerance 10 Lecture and dependence, Affinity, efficacy and potency. Dose response relationships, unusual and 11 PPT/Lecture adverse responses of drugs Structurally specific and nonspecific drugs. Q & A 12 PPT/Lecture Ferguson’s principle. Session Second Internal Examination MODULE II : Toxicology and Biotransformations (12h)
13 Receptor theories and receptor models- rate PPT/Lecture
theory 14 Occupancy and induced fit theory PPT/Lecture 15 Activation-aggregation and molecular PPT/Lecture petrubation theories 16 General concepts of toxicity, Acute, subacute & Lecture Q & A chronic toxicity tests Session 17 Teratogenicity & carcinogenicity,, LD50, ED50 Lecture 18 MIC- anti infectives, habituation & addiction Lecture 19 Factors affecting biotransformation, site of Lecture biotransformations 20 Effect of biotransformation on the biological PPT/Lecture activity of drugs First Internal Examination 21 Biotransformation- Oxidation, reduction, PPT/Lecture
hydroxylation, hydrolysis 22 Reactions and mechanism with specific drug PPT/Lecture molecules 23 PhaseII biotransformations -gluconideration, PPT/Lecture sulfation, conjugation with glutathione acetylation methylation- illustrate with suitable drug molecules 24 Chemical and pharmacological roles of Phase I Lecture Q & A & phase II transformations. Session Second Internal Examination MODULE III : Anti-Infective agents (12h) Sulphonamides- structure, chemistry, SAR and 25 Lecture mechanism of action Sulfadiazine Sulfamethoxole, sulfones, 26 cotrimoxazole(sufamethoxole+ trimethoprim.) Lecture Zwitter ion. Sulfonamides: Synthesis of: Sufadiazine, 27 Lecture sufamethoxole 28 Synthesis of pyrimethamine, Dapsone Lecture Antifungal agents: study of Amphotrcine B, 29 PPT/Lecture grisofulvin physical and chemical properties Study of nystatin, ketoconazole, clotrimazole, 30 PPT/Lecture flucoconozole, 5-flucytosine Antiprotozoal agents: Chemistry, mechanism of 31 action and therapeutic uses of Anti Amoebic PPT/Lecture and Antihelmintics Antiviral drugs- mode of action and therapeutic 32 PPT/Lecture uses First Internal Examination Chemistry and mechanism of action of Q & A 33 PPT/Lecture amatidine, Ribavirin. Session Chemistry and mechanism of action of 34 PPT/Lecture Abacavir,acyclovir, ositamvir, vidarabin Chemistry and mechanism of action of 35 Ganciclovir, fosfonet, combivir. Synthesis of –, PPT/Lecture Sulphanilamide, Dapsone, Grisofulvin
Synthesis of 5-flucytosine, acyclovir, Adefovir, 36 Lecture Quiz Combivir, Didanisine, ganciclovir Second Internal Examination MODULE IV : Drugs Acting on CVS (12 h) Pharmacology and SAR of Cardiotonic drugs: Q & A 37 cardiac glycosides chemistry of digoxin and PPT/Lecture Session digitoxin Synthesis of Dobutamide, milrinone 38 Antiarrhythmic drugs:quinidine, disopyramide, PPT/Lecture lidocaine, phenytoin and procainamide β-blockers-propranolol. Calcium channel blockers-verapamil synthesis of lidocaine , 39 PPT/Lecture phenetoin, bretilium. Neurone blockers - bretilium Antihypertensive Drugs: peripheral antiadrenergics-prazosin and terazosin. 40 PPT/Lecture Reserpine, clonidine and methyldopa. β- atenolol and labetalol Calcium channel blockers-nifedipine and 41 PPT/Lecture amlodipine. ACE inhibitors-captopril Angiotensin receptor blockers-losartan. 42 Lecture Diuretics-thiazide diuretics Synthesis of: captopril, methyl DOPA, 43 amlodepine. Antianginal drugs: vasodilators- PPT/Lecture nitrites and nitrates, β-blockers-propranolol Calcium channel blockers-verapamil and 44 nifedipine. Miscellaneous-dipyridamoland PPT/Lecture aspirin First Internal Examination 45 Synthesis : verapamil. Anticoagulants: heparin PPT/Lecture Coumarin derivatives and indanedione 46 PPT/Lecture derivatives Antilipidemic agents: Statins- 47 PPT/Lecture Quiz lovastatin,simvastatin, fluvastatin Synthesis of fluvastatin. Fibrates-clofibrate, 48 PPT/Lecture and cholestyramine resin.
Second Internal Examination MODULE V : Chemotherapeutic Agents (12 h) Antibiotics- Classification, mechanism of action 49 PPT/Lecture and therapeutic uses.- penicillin Cephalpsporins, Quinolones, Aminoglycosides, 50 PPT/Lecture Carbapenems, macrolide and others Antibiotic resistance mechanism and 51 PPT/Lecture implications in therapeutics Synthetic studies of :Penicillin V, Cefotaxim, 52 Meropenem, Streptomycin, Ciprofloxacin, PPT/Lecture Video Trimethoprim Chemotherapy of Tuberculosis: First line Drugs 53 and second line drugs- chemistry PPT/Lecture Pharmacology The problem of MDR tuberculosis. Recent 54 PPT/Lecture innovations. Synthesis of isoniazid Synthesis of pyrazinamide, ethionamide, 55 PPT/Lecture paraaminosalicylic acid. Antimalerials : Chemotherapy of Malaria, 56 mode of action of the various classes of drugs Lecture used, Chemistry, SAR and Drug resistance Study of the following drugs in the treatment , 57 efficacy , problem of side effects of PPT/Lecture Quiz Quninesulphate, Chloroquine, primaquine 58 Mephloquine, quinacrine ,proguanil, plaquenil PPT/Lecture Second Internal Examination Drug combinations in the therapy of Malarial 59 parasite. Treatment of drug resistant malaria, PPT/Lecture recent progress Synthetic studies of chloroquine, primaquine, 60 PPT/Lecture proguanil, malarone. CIA-II MODULE VI : Analgesics, Antipyretics & Anti infammatory drugs (12h) Mechnism of action and SAR of: Different 61 PPT/Lecture types of analgesia 62 Narcotic analgesics - morphine and codeine, PPT/Lecture
Phenyl(ethyl) piperidines, Diphenylheptanones, fentanyl analogues, nalfurafine Antipyretics and NSAIDs: Basic idea of COX I & Demo 63 Lecture II Iinhibitors video Salicylates - aspirin, p-aminophenol 64 Lecture derivatives-paracetamol, phenacetin Pyrazolidinediones – Phenylbutazone, 66 Lecture Anthranilicacid derivatives – Flufenamicacid Indoleacetic acid derivatives-indomethacin, 67 Arylacetic/ Propionicacid derivatives – PPT/Lecture ibuprofen and Ketoprofen) Arylacetic/ Propionicacid derivatives 68 PPT/Lecture flubiprofen and diclofenac Oxicams – tenoxicam, Drugs used for gout - 69 PPT/Lecture allopurinol, Colchicine, Pegloticase Antiinflammatory: Sulindac,Naproxen, Novel 70 Analgesics: Funapide, Raxatrigine (Structure Lecture Quiz only). Second Internal Examination Synthesis of the following drugs-levorphanol, 71 pethidine, methadone, phenyl butazone, PPT/Lecture flufenamic acid Synthesis of Diclofenac, tenoxicam, allopurinol 72 PPT/Lecture and Codeine, Ketoprofen, Naproxen
INDIVIDUAL ASSIGNMENTS/SEMINAR – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) 1 08/10/2018 Synthesis of Anti-infective agents 2 07/11/2018 SAR of drugs used as antipyretics
GROUP ASSIGNMENTS/ACTIVITES – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) 1 06/11/2018 Previous CSIR questions (Group activity)
References
01. G. Patrick, Medicinal Chemistry, BIOS. 2001.
02. T. Nogrady, D.F. Weaver, Medicinal Chemistry, Oxford University Press, 2005.
03. W.O. Foye, T.L. Lemke, D.A. Williams, Principles of Medicinal Chemistry, 4thEdn., Williams & Wilkins, 1995.
04. J.P. Remington, Remington’s Pharmaceutical Sciences, Vol.13, , 19th Edn., Mack,1990.
05. D. Sriram , P. Yogeswari, Medicinal Chemistry, Pearson Education India, 2010.
06. K. D. Tripathi, Essentials of Medical Pharmacology, 6th Edn.,Jaypee, 2008
07. L.S. Goodman, A. Gillman, The Pharmacological Basis of Therapeutics, 10thEdn., McGraw Hill, 2001.
08. S.S. Kadam, Principles of Medicinal Chemistry, Vol.I& II, Pragati Books, 2008.
09. A. Kar, Medicinal Chemistry, New Age International, 2007.
10. C.O. Wilson, J.M. Beale, J.H. Block, Textbook of Organic Medicinal and
Pharmaceutical Chemistry, 12th Edn., Lippincott Williams and Wilkins, 2010
MSC APPLIED CHEMISTRY - PROGRAMME SEMESTER 3 PHARMACEUTICAL COURSE CODE AND TITLE 16P3CPHT10 and ORGANIC SYNTHESES CREDIT 4 HOURS/WEEK 4 HOURS/SEM 72 DR. JOSEPH T MOOLAYIL, DR. V.S SEBASTIAN, DR. FACULTY NAME FRANKLIN J, DR.GRACE THOMAS
Course Objectives
To describe the applications of oxidation and reduction techniques in organic syntheses. To illustrate modern synthetic methods and applications of reagents. To explain different methods for the construction of carbocyclic and heterocyclic ring systems. To understand the principles and applications of protecting groups in chemistry. To apply retrosynthetic analysis to design the synthesis of a target molecule. To understand the concept of molecular recognition and supramolecular chemistry
LEARNING VALUE SESSION TOPIC REMARKS RESOURCES ADDITIONS Unit 1 : Organic Synthesis via Oxidation and Reduction (18 hours)
Survey of organic reagents and reactions in PPT video 1 organic chemistry with special reference to oxidation and reduction.
2 Metal based and non-metal based oxidations of PPT/Lecture alcohols to carbonyls (Chromium, Manganese) Metal based and non-metal based oxidations of PPT/Lecture 3 alcohols to carbonyls(aluminium and DMSO based reagents)
Alkenes to epoxides (peroxides/per acids PPT/Lecture Assignment 4 based)-
5 Sharpless asymmetric epoxidation. PPT/Lecture
6 Jacobsen epoxidation, Shi epoxidation PPT/Lecture
Alkenes to diols (Manganese and Osmium Lecture 7 based)-
8 Prevost reaction Lecture
9 Woodward modification Lecture
Alkenes to carbonyls with bond cleavage Lecture 10 (Manganese and lead based, ozonolysis)
Alkenes to alcohols/carbonyls without bond PPT/Lecture 11 cleavage
Hydroboration-oxidation, Wacker oxidation, PPT/Lecture Quiz 12 selenium/chromium based allylic oxidation.
Ketones to ester/lactones- Baeyer-Villiger Lecture 13 oxidation
Catalytic hydrogenation (Heterogeneous: Lecture 14 Palladium/Platinum/Rhodium and Nickel. Homogeneous: Wilkinson).
Metal based reductions- Birch reduction, Lecture 15 pinacol formation, acyloin formation
16 Hydride transfer reagents from Group III and Lecture Group IV in reductions - LiAlH4,. DIBAL-H, Red-Al, NaBH4 and NaCNBH3, PPT/Lecture 17 selectrides
18 Trialkylsilanes and trialkylstannane. Meerwein- PPT/Lecture Pondorff-Verley reduction. Baker’s yeast Unit 2 : Modern Synthetic Methods and Reagents (15 Hours)
19 Baylis-Hillman reaction. PPT/Lecture
20 Henry reaction, Nef reaction PPT/Lecture
21 Kulinkovich reaction, Ritter reaction PPT/Lecture
First Internal Examination
22 Sakurai reaction, Tishchenko reaction, Ugi PPT/Lecture
reaction
23 Noyori reaction. Brook rearrangement PPT/Lecture
24 Tebbe olefination. PPT/Lecture Assignment
Metal mediated C-C and C-X coupling reactions: PPT/Lecture 25 Heck Reaction
26 Stille Reaction PPT/Lecture
27 Suzuki, Suzuki-Miyaura, PPT/Lecture
28 Negishi-Sonogashira, Nozaki-Hiyama PPT/Lecture
Buchwald-Hartwig, Ullmann and Glaser PPT/Lecture 29 coupling reactions.
30 Wohl-Ziegler reaction. PPT/Lecture
31 Reagents such as NBS Lecture
32 DDQ and DCC Lecture
33 Lecture Gilmann reagent. Unit 3: Construction of Carbocyclic and Heterocyclic Ring Systems (12 Hours)
34 Different approaches towards the synthesis of Lecture three, four, five and six-membered rings. Photochemical approaches for the synthesis of 35 four membered rings- oxetanes and cyclobutanes
Ketene cycloaddition (inter and intra PPT/Lecture 36 molecular), Pauson-Khand reaction,
37 Volhardt reaction, Bergman cyclization, PPT/Lecture
38 Nazarov cyclization, Mitsunobu reaction, PPT/Lecture
Cation-olefin cyclization and radical-olefin 39 cyclization.
Inter-conversion of ring systems (contraction PPT/Lecture 40 and expansion)-Demjenov reaction
Reformatsky reaction. Construction of PPT/Lecture 41 Macrocyclic rings-ring closing metathesis.
Formation of heterocyclic rings: 5-membered PPT/Lecture 42 ring heterocyclic compounds with one or more than one hetero atom like N, S
Formation of heterocyclic rings: 5-membered Lecture Quiz 43 ring heterocyclic compounds with one or more than one hetero atom like O -
44 Pyrrole, furan, thiophene, PPT/Lecture
45 Imidazole, thiazole and oxazole PPT/Lecture
Unit 4: Protecting group Chemistry (9 Hours)
46 Protection and deprotection of hydroxy, PPT/Lecture carboxyl Carbonyl, and amino groups. Chemo and regio PPT/Lecture 47 selective protection and deprotection.
Illustration of protection and deprotection in Lecture 48 synthesis. Protection and deprotection in peptide PPT/Lecture 49 synthesis. common protecting groups used in peptide PPT/Lecture 50 synthesis
51 protecting groups used in solution phase PPT/Lecture
52 solid phase peptide synthesis (SPPS). PPT/Lecture
Functional equivalence and reactivity PPT/Lecture 53 Umpolung.
Role of trimethyl silyl group in organic PPT/Lecture 54 synthesis
Unit 5: Retrosynthetic Analysis(9 Hours)
Basic principles and terminology of PPT/Lecture 55 reterosynthesis: method.
56 Synthesis of aromatic compounds, one group PPT/Lecture
two group C-X disconnections, one group C-C PPT/Lecture 57 and two group C-C disconnections.
Amine and alkene synthesis: important PPT/Lecture Video 58 strategies of retrosynthesis,
Functional group transposition, important PPT/Lecture 59 functional group interconversions.
60 Important functional group interconversions, PPT/Lecture
61 Enantioselective synthesis of Corey lactone PPT/Lecture
62 longifolene and luciferin. PPT/Lecture Umpolung equivalent – Peterson olefination, Lecture 63 enolate formation, Ireland
Second Internal examination
Unit 6: Molecular Recognition and Supramolecular Chemistry(9 Hours )
Concept of molecular recognition- host-guest PPT/Lecture 64 complex formation-
Forces involved in molecular recognition. Lecture Quiz 65 Molecular receptors:
Cyclodextrins, crown ethers, cryptands, PPT/Lecture 66 spherands
67 Tweezers, carcerands PPT/Lecture
68 cyclophanes, calixarenes. PPT/Lecture
Importance of molecular recognition in PPT/Lecture 69 nucleic acids and protein.
Applications of supramolecular complexes in PPT/Lecture 70 medicine-
71 targeted drug delivery PPT/Lecture
72 Revision Lecture
INDIVIDUAL ASSIGNMENTS/SEMINAR – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) 1 2/10/2018 Retrosynthetic analysis- problems 2 28/10/2018 Seminar on Reagents
GROUP ASSIGNMENTS/ACTIVITES – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) 1 05/11/2018 Protecting groups (Group Discussion)
References
M.B. Smith, Organic Synthesis, 3rd Edn.,Wavefunction Inc., 2010. F.A. Carey, R. I. Sundberg, Advanced Organic Chemistry, Part A and B, 5th Edn., Springer, 2007. W. Carruthers, I. Coldham, Modern Methods of Organic Synthesis, 4th Edn., Cambridge University Press, 2004. J. Clayden, N. Greeves, S. Warren,P. Wothers, Organic Chemistry, Oxford University Press, 2001. R. Noyori, Asymmetric Catalysis in Organic Synthesis, John Wiley & Sons, 1994.
MSC APPLIED CHEMISTRY - PROGRAMME SEMESTER 3 PHARMACEUTICAL
COURSE CODE AND CREDIT 4 TITLE 16P3CPHT11: Physical Chemistry III
HOURS/WEEK 4 HOURS/SEM 72
Dr. K B Jose, Dr. Thommachan Xavier, Dr Jorphin Joseph, FACULTY NAME Dr Jinu George
COURSE OBJECTIVES
To apply the principles of chemical kinetics in different types of reactions.
To apply the principles of chemical kinetics in different types of solutions and enzyme catalysis.
To analyze the theories of electrochemistry with its applications in measurements.
To describe the chemistry of surfaces and its applications in colloids and macromolecules.
To explain the chemistry of light
VALUE SESSION TOPIC LEARNING REMARKS RESOURCES ADDITIONS MODULE I : CHEMICAL KINETICS I (14h)
Theories of reaction rates: Collision theory- PPT video 1. steric factor, potential energy surfaces.
Conventional transition state theory-Eyring PPT/Lecture 2. equation, Comparison of the two theories.
Thermodynamic formulation of the two PPT/Lecture 3. theories, Thermodynamicformulation of the reaction rates.
Significance of ∆G*, ∆H* and∆S*.Volume of PPT/Lecture e-resource 4. activation. Effect of pressure and volume on velocity of gas reactions.
5. Introduction to Molecular Reaction Dynamics PPT/Lecture
6. Various types of reaction theories PPT/Lecture
7. Lindemann-Hinshelwood mechanism Lecture
8. Qualitative idea of RRKM theory Lecture
Fast reactions: relaxation,Flow and Shock 9. methods,Flash photolysis.
NMR and ESR a methods of studying fast Lecture 10. reactions.
Chain reactions, free radical and chain PPT/Lecture 11. reactions, Steady state treatment,
12. kinetics of H2-Cl2 and H2-Br2 reactions PPT/Lecture
Rice –Herzfeld mechanism, Branching chains PPT/Lecture
13. H2-O2, Semenov-Hinshelwood mechanism of explosive reactions.
Kinetics of polymerization: mechanism of step Lecture 14. growth Ionic and addition polymerization Kinetics of anionic and cationic polymerization.
REVISION
MODULE II: CHEMICAL KINETICS II (14h)
Reactions in solution: factors determining PPT video 15. reaction rates in solutions
16. effect of dielectric constant and ionic strength PPT/Lecture
cage effect, Bronsted-Bjerrum equation, PPT/Lecture 17. primary and secondary kinetic salt effect,
Influence of solvent on reaction rates, PPT/Lecture e-resource 18. significance of volume of activation linear free energy relationship 19. kinetic isotope effect PPT/Lecture
Homogenous catalysis -Acid-base catalysis: PPT/Lecture van’t Hoff and Arrhenius intermediates for 20. prototropic and protolytic mechanisms with examples specific and general catalysis. 21. Skrabal diagram, Bronsted catalysis law Lecture
22. Acidity function. Lecture
23. Enzyme catalysis and its mechanism
24. Michelis-Menten equation Lecture
Effect of pH and temperature on enzyme PPT/Lecture 25. catalysis.
Heterogeneous catalysis Mechanisms of: PPT/Lecture unimolecular and bimolecular surface reactions, 26. Langmuir-Hinshelwood and Langmuir-Rideal mechanism- ARRT of surface reactions-mechanisms of PPT/Lecture 27. catalyzed reactions like ammonia synthesis,
hydrogenation of ethylene and catalytic Lecture 28. cracking of hydrocarbons and related reactions.
REVISION
MODULE III : ELECTROCHEMISTRY I (12h)
Theories of ions in solution, Ion activity, Ion-ion 29. Lecture and ion-solvent interaction
Born’s model, Debye-Huckel theory, Ionic 30. Lecture atmosphere.
The Debye-Huckel-Onsager conductance 31. equation-its derivation and experimental Lecture verification
Validity of DHO equation for aqueous and non- 32. Lecture aqueous solutions.
33. Deviations from DHO conductance equation. Lecture
Extension of DHO equation to ion solvent 34. PPT/Lecture interactions.
35. Derivation of Debye-Huckel limiting law. PPT/Lecture
Conductance measurements Results of 36. conductance measurements Factors affecting PPT/Lecture conductance
37. Debye Falkenhagen and Wein effects, PPT/Lecture
38. Walden rule, abnormal ionic conductance. PPT/Lecture
Electro kinetic effects - electrophoresis, electro 39. Lecture osmosis, streaming potential
sedimentation potential – Donnan membrane 40. Lecture equilibrium.
REVISION
MODULE IV : SURFACE CHEMISTRY AND COLLOIDS (18h)
Gas adsorption at solid surface - influencing PPT/Lecture 41. factors
Bonding of adsorbate to solid – adsorption PPT/Lecture 42. isotherms –
43. Langmuir (derivation) PPT/Lecture
44. BET (derivation) Determination of surface area. Lecture Quiz
Spectroscopic techniques for probing solid Q &Ans Lecture 45. surfaces Session
46. Temperature programmed desorption (TPD) PPT/Lecture
Reflection absorption infrared spectroscopy PPT/Lecture 47. (RAIRS)
High resolution electron energy loss PPT/Lecture 48. spectroscopy (HREELS).
49. Surface films -Introduction film pressure PPT/Lecture
50. criteria for spreading of one liquid on another Lecture
51. Adsorption from solutions PPT/Lecture
Electrostatic adsorption, Gibbs adsorption PPT/Lecture 52. isotherm (derivation) - verifications.
Colloids &Micellar systems Types of colloids, PPT/Lecture 53. Electrical properties of colloids
54. Electrical double layer, zeta potential PPT/Lecture
55. Miscelles, and miscellisation PPT/Lecture
56. Structure of miscelles - ionic miscelles. PPT/Lecture
Adsorption from solutions - electrostatic PPT/Lecture 57. adsorption
Gibbs adsorption isotherm (derivation) - PPT/Lecture 58. verifications.
REVISION
MODULE V : PHOTOCHEMISTRY (14h)
59. Laws of Photochemistry PPT/Lecture
Grothus –Draper Law, Stark-Einstein’s Law, Laws of light absorption, Quantum yield. PPT/Lecture 60. Chemical actinometry
61. Excimers and exciplexes, photosensitization PPT/Lecture Video
chemiluminescence, bioluminescence, thermo PPT/Lecture 62. luminescence
63. Applications in daily life PPT/Lecture
64. pulse radiolysis, hydrated electrons
photo stationary state, dimerization of Lecture Debate 65. anthracene.
Photo physical processes in electronically PPT/Lecture 66. excited molecules
Jablonsky diagram Fluorescence and PPT/Lecture 67. Phosphorescence.
68. Quenching of fluorescence and its kinetics PPT/Lecture
Stern-Volmer equation, static and dynamic PPT/Lecture quenching pulse radiolysis, hydrated electrons, 69. photo stationary state, dimerization of anthracene..
Concentration quenching, E-type and P-type. PPT/Lecture 70. Effect of temperature on emissions,
Two photon absorption spectroscopies Lecture video 71. Principle of utilization of solar energy
Solar cells and their working. Photochemistry Lecture 72. of vision. delayed fluorescence
Revision
INDIVIDUAL ASSIGNMENTS/SEMINAR – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) 1 I CIA Imaging in medicine 2 II CIA Surface studies relevance in current research
GROUP ASSIGNMENTS/ACTIVITES – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) 1 I INT Chemistry of vision (Group Discussion) 2 II INT Adsorption in industry
References 1. J. Rajaram, J.C. Kuriakose, Kinetics and Mechanisms of Chemical Transformations, Macmillan India, 2000. 2. K.J. Laidler, Chemical kinetics, 3rdEdn. Harper & Row, 1987. 3. C. Kalidas, Chemical Kinetic Methods: Principles of Fast Reaction Techniques and
Applications, New Age International, 2005. 4. J.W. Moore, R.G. Pearson, Kinetics and Mechanisms, John Wiley & Sons, 1981. 5. P.W. Atkins, Physical Chemistry, ELBS, 1994. 6. D.A. McQuarrie, J.D. Simon, Physiacl chemistry: A Molecular Approach, University Science Books,1997 8. K.K. Rohatgi-Mukherjee, Fundamentals of Photochemistry, 2ndEdn. New Age International, 1986. 9. G. Aruldhas, Molecular structure and Spectroscopy, PHI Learning, 2007. 10. M.R Wright, An Introduction to Chemical Kinetics, John Interscience-2007 11. A.W &Sons, Adamson, A.P. Gast, Physical chemistry of sufaces,6thEdn,John Wiley, 1997 12. D.O. Cowan ,R.L. Drisko , Elements of Organic Photochemistry, Plenum Press,.1976
MSC APPLIED CHEMISTRY - PROGRAMME SEMESTER 3 PHARMACEUTICAL COURSE CODE 16P3CPHT12- SPECTROSCOPIC METHODS CREDIT 3 AND TITLE IN CHEMISTRY HOURS/WEEK 3 HOURS/SEM 54 FACULTY NAME DR. JOSEPH T MOOLAYIL, Dr. JUNE CYRIAC
COURSE OBJECTIVES
To describe the principles of UV-visible, Chiro-optical, IR, NMR and Mass spectroscopic techniques.
To ilustrate various spectroscopic techniques using simple problems.
To elucidate the structure of an unknown organic compound using data from various spectroscopic techniques.
VALUE SESSION TOPIC LEARNING REMARKS RESOURCES ADDITIONS
MODULE I : Ultraviolet-Visible and Chiroptical Spectroscopy (9h) 1 Energy levels and selection rules PPT video
2 Woodward-Fieser Rule PPT/Lecture 3 Fieser-Kuhn Rule PPT/Lecture
Solvent effect, Stereochemical effect-non- 4 PPT/Lecture e-resource conjugated interactions.
5 Applications, Chiroptical properties- ORD PPT/Lecture
6 CD, octant rule PPT/Lecture
7 Chiroptical properties- ORD Lecture
8 Axial haloketone rule, Cotton effect. Lecture
9 Problems based on the above topics. Lecture MODULE II : Infrared Spectroscopy (9h)
10 Fundamental vibrations PPT/Lecture
11 Characteristic regions of the spectrum PPT/Lecture
12 Continued PPT/Lecture
Influence of substituents, ringsize, hydrogen 13 bonding, vibrational coupling and field effect PPT/Lecture on frequency.
14 Continued PPT/Lecture
15 Determination of stereochemistry by IR Lecture technique.
16 IR spectra of olefins and arenes, - C=C bonds Lecture and C=O bonds.
17 Problems-spectral interpretation with Lecture examples.
18 Continued
CIA-1
MODULE III : Nuclear Magnetic Resonance Spectroscopy (18h)
1 19 A comparison of the NMR phenomena of H and Lecture 13C nuclei. 20 Factors affecting chemical shift - PPT/Lecture
21 Relaxation processes, chemical and magnetic PPT/Lecture
non-equivalence 22 local diamagnetic shielding and magnetic PPT/Lecture anisotropy. 23 Proton and 13C NMR scales PPT/Lecture
24 Spin-spin splitting:AX, AX2 Lecture
Scheduling criteria, Scheduling Algorithms AX , 25 3 Lecture A2X3, AB, ABC, AMX type coupling
26 First order and non-first order spectra - Lecture Pascal’s triangle 27 Coupling constant - mechanism of Lecture coupling,heteronuclear couplings-Karplus curve Quadrupole broadening and decoupling - 28 PPT/Lecture diastereomeric protons - virtual coupling
Long range coupling-epi, peri, bay effects. NOE 29 PPT/Lecture - NOE and cross polarization.
Simplification non-first order spectra: shift 30 PPT/Lecture reagents-mechanism
Spin decoupling-double resonance and off PPT/Lecture 31 resonance decoupling.
32 2D NMR, HOMOCOSY and HETEROCOSY PPT/Lecture 33 Continued PPT/Lecture
34 Polarization transfer. PPT/Lecture
35 Problems-Spectral interpretation with Lecture Quiz examples.
Q &Ans 36 Problems-Spectral interpretation with Lecture examples. Session
MODULE IV : Mass Spectrometry (9h)
37 Molecular ion: ion production methods (EI). PPT/Lecture
38 Soft ionization methods: SIMS, FAB, CI, MALDI, PPT/Lecture Electrospray ionization.
Mass Analysis- Magnetic and electric fields, 39 PPT/Lecture Quadrupole
40 TOF and ion trap mass analysers Lecture
41 Fragmentation patterns in EI MS PPT/Lecture
42 Continued PPT/Lecture
43 Nitrogen and ring rules- McLafferty PPT/Lecture rearrangement - applications. 44 HRMS, MS-MS, MIKES,CAD, FTMS,LC-MS, GC- PPT/Lecture MS. 45 Problems-Spectral interpretation with PPT/Lecture examples. MODULE V : Structural Elucidation Using Spectroscopic Techniques (9h)
Identification of structures of unknown organic molecules based on the data from IR, 1HNMR 46 PPT/Lecture and 13CNMR spectroscopy and mass spectroscopy
Identification of structures of unknown organic molecules based on the data from IR, 1HNMR 47 PPT/Lecture and 13CNMR spectroscopy and mass spectroscopy
Identification of structures of unknown organic molecules based on the data from IR, 1HNMR 48 PPT/Lecture and 13CNMR spectroscopy and mass spectroscopy
Identification of structures of unknown organic molecules based on the data from IR, 1HNMR 49 PPT/Lecture Video and 13CNMR spectroscopy and mass spectroscopy
50 Interpretation of the given UV-Vis, IR NMR and PPT/Lecture mass spectra. Interpretation of the given UV-Vis, IR NMR and 51 PPT/Lecture mass spectra.
52 Interpretation of the given UV-Vis, IR NMR and
mass spectra.
Interpretation of the given UV-Vis, IR NMR and 53 Lecture mass spectra.
Interpretation of the given UV-Vis, IR NMR and 54 PPT/Lecture mass spectra.
CIA II
INDIVIDUAL ASSIGNMENTS/SEMINAR – Details & Guidelines
Topic of Assignment & Nature of assignment Date of (Individual/Group – Written/Presentation – Graded or Non- completion graded etc) 2/9/2018 Problems on Spectral interpretation Identification of structures of unknown organic molecules based 28/10/2018 on the data from IR, 1HNMR and 13CNMR spectroscopy and mass spectroscopy
GROUP ASSIGNMENTS/ACTIVITES – Details & Guidelines Topic of Assignment & Nature of Date of assignment (Individual/Group –
completion Written/Presentation – Graded or Non- graded etc) Interpretation of the given UV-Vis, IR NMR and 1 09/11/2018 mass spectra.
References 1. D.L. Pavia, G.M. Lampman, G.S.Kriz, Introduction to Spectroscopy: A Guide for Students of Organic Chemistry (3rd Ed.), Thomson. 2004. 2. W. Kemp, Organic Spectroscopy, 2nd edition, ELBS-Macmillan, 1987. 3. D. Nasipuri, Stereochemistry of Organic Compounds: Principles and Applications, Third Edition, New Age Publications, New Delhi, 2010. 4. D.F.Taber, Organic Spectroscopic Structure Determination: A Problem Based Learning Approach, Oxford University Press, 2009. 5. R. M. Silverstein, G.C. Bassler, T. C. Morril, Spectroscopic Identification of Organic Compounds,John Wiley, 1991.
6. D. H. Williams, I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata McGraw Hill, 1988. 7. F. Bernath, Spectra of Atoms and Molecules, 2nd Edition, Oxford University Press, 2005. 8. E. B. Wilson, Jr., J. C. Decius, P. C. Cross, Molecular Vibrations: The Theory of Infrared and Raman Spectra, Dover Publications, 1980. 9. Atta-Ur-Rahman, M.I. Choudhary, Solving Problems with NMR Specroscopy, Academic Press, New York, 1996. 10. L. D. Field, S.Sternhell, J. R. Kalman, Organic Structures from Spectra (fourth edition), Wiley, 2008. 11. Online spectroscopy problems and solutions like www.orgchem.collarado.edu/Spectroscopy/Problems www.chem.ucla.edu/webSpectra