Antidepressant Drugs in Oral Fluid Using Liquid Chromatography –Tandem Mass Spectrometry
Journal of Analytical Toxicology, Vol. 34, March 2010 Antidepressant Drugs in Oral Fluid Using Liquid Chromatography –Tandem Mass Spectrometry Cynthia Coulter, Margaux Taruc, James Tuyay, and Christine Moore* Immunalysis Corporation, 829 Towne Center Drive, Pomona, California 91767 Abstract graines, or sleep disorders. Antidepressant drugs may also cause impairment of cognitive and psychomotor functioning An analytical procedure for the determination of widely relevant to driving, although this impairment is reportedly prescribed drugs for the treatment of depression and anxiety less severe in second generation antidepressants such as se - disorders, including amitriptyline, cyclobenzaprine, imipramine, lective serotonin reuptake inhibitors (SSRIs) than with more dothiepin, doxepin, fluoxetine, sertraline, trimipramine, traditional tricyclic antidepressants (TCAs) such as amitripty - protriptyline, chlorpromazine, clomipramine, and some of their line (1,2). Patients receiving long-term treatment with SSRI metabolites (nortriptyline, desmethyldoxepin, desipramine, and serotonin-norepinephrine reuptake inhibitor (SNRI)-type desmethyltrimipramine, norclomipramine) in oral fluid has been drugs produce impaired driving performance (3). However, developed and validated using liquid chromatography with tandem Brunnauer et al. (2) showed that there were actually no sta - mass spectral detection. The oral fluid samples were collected using the Quantisal™ device, screened with enzyme-linked tistically significant differences between patients treated
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