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Arij Daou BSC 5936 – Fall 2011 Arij Daou BSC 5936 – Fall 2011 Annotated Bibliography - Voltammetry Donita L. Robinson, B. Jill Venton, Michael L.A.V. Heien, and R. Mark Wightman. “Detecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo.” Clinical Chemistry 49:10 1763–1773 (2003). - This is the paper we used to study the background behind voltammetry. It’s a good paper by Whightman et al where they study dopamine release using fast scan cyclic voltammetry. The paper goes over the major roles of domapine extracellularly and intracellularly and then goes over the basic components of voltammetry, the types of electrodes to use and how to measure using this technique, particularly what are the essential components and how to read voltomograms and the mathematics behind it. Stephanie Fulton, Dominic Thibault, Jose A.Mendez, Nicolas Lahaie. “Contribution of Kv1.2 Voltage-gated Potassium Channel to D2 Autoreceptor Regulation of Axonal Dopamine Overflow.” THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 11, pp. 9360–9372 - This is a nice paper that combined electrophysiology, behavior, immunohistochemistry and voltammetry all at once. It is primarily concerned with impairments of dopaminergic release because that is associated with neurological disorders. They studied the the contribution of Kv1 voltage-gated potassium channels of the Shaker gene family to the regulation of dopamine release. They show in this paper how the D2-AR activation plays a role in increasing Kv1.2 currents and thus modulating brain activity. Garret D. Stuber, Marianne Klanker, Bram de Ridder, M. Scott Bowers, Ruud N. Joosten, Matthijs G. Feenstra, Antonello Bonci. “Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons.” Science 321, 1690 (2008) - This is a nice paper that combines behavioral neuroscience with voltammetric techniques. It is widely known that dopaminergic neurons are activated by certain aspects of reward behavior; however, little is known about the cellular mechanisms that underlie this phenomenon. We used in vivo voltammetry and in vitro patch-clamp electrophysiology and showed that both dopamine release plays a major role in reward predictive cues. Also, it is primarily the strength of the synaptic input onto the dopamine neurons that transform the mechanism into a reward-predictive process. Kevin J. Bender, Christopher P. Ford, and Laurence O. Trussell. “Dopaminergic Modulation of Axon Initial Segment Calcium Channels Regulates Action Potential Initiation.” Neuron 68, 500–511 - This is a great paper that combined electrophysiology with drug manipulation, gene regulation and voltammetry. The primary focus was on the action potentials that initiate in the axon initial segment (AIS), a specialized compartment enriched with Na+ and K+ channels. They examined the regulatory pathways that control AIS Ca2+ channel activity in the brainstem interneurons and showed that T-type Ca2+ channels play a major role where they are down regulated by dopamine receptor activation acting via protein kinase C, which in turn reduced neuronal output. Marianne Fillenz. “In vivo neurochemical monitoring and the study of behavior.” Neuroscience and Biobehavioral Reviews 29 (2005) 949–962 - In this paper, the authors used voltammetry in vivo to measure concentrations of dopamine and noradrenaline of specific brain regions. They studied first the glutamate release and how does TTX affect its behavior. While searching for the identity of the excitatory and inhibitory neurotransmitters they discovered a large number of chemical compounds that were synthesised, stored and released from nerve terminals, particularly the monoamines noradrenaline and dopamine. They then apply microdialysis of noradrenaline and dopamine and in vivo voltammetry to measure their release in fast time resolution similar to the electrophysiological recordings. Paul A. Garris, George V. Rebec. “Modeling fast dopamine neurotransmission in the nucleus accumbens during behavior” Behavioural Brain Research 137 (2002) 47-63. - In this paper, the authors go over the literature that describes electrophysiological and real-time voltammetric approaches and then they propose a general model of phasic DA signaling in the nucleus accumbens that links the changes in DA electrical activity and extracellular dynamics. It’s a nice paper where the mathematical model motivates the experimental research that had been carried out by voltammetric techniques. Sara R. Jones, Raul R. Gainetdinov, R. Mark Wightman, and Marc G. Caron. “Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter.” The Journal of Neuroscience, 1998, 18(6):1979–1986 - Here the authors used fast scan voltammetry to monitor the sequence of actions of Amphetamine AMPH by looking at the real time changes of DA in the extracellular fluid of intact tissue. Amphetamine is widely known to inhibit the uptake and cause the release of dopamine (DA) from presynaptic terminals. Through voltammetry, they showed that dopamine transporters are required for the releasing action, but not the vesicle-depleting action, of AMPH on DA neurons. Hsing-Chen Tsai, Feng Zhang, Antoine Adamantidis. “Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning.” Science 324, 1080 (2009), - In the paper, the authors show that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning. It is known that the ventral tegmental area (VTA) dopaminergic neurons fire action potentials under different behavioral conditions. Here they used voltammetry and other tools to selectively stimulate VTA dopaminergic neuron action potential firing in vivo and found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicit dopamine transients. Trisha L. Vickrey, Barry Condron, and B. Jill Venton. “Detection of Endogenous Dopamine Changes in Drosophila melanogaster Using Fast-Scan Cyclic Voltammetry.” Anal. Chem. 2009, 81, 9306–9313. - This is a great paper where they first the method to measure endogenous dopamine in an intact Drosophila nervous system (despite the small size) and study genetic and pharmacological manipulations of dopamine release and uptake. They used fast-scan cyclic voltammetry to measure the extracellular dopamine changes. Catarina A. Owesson-White, Joseph F. Cheer, Manna Beyene, Regina M. Carelli, and R. Mark Wightman. “Dynamic changes in accumbens dopamine correlate with learning during intracranial self-stimulation.” PNAS, 2008. - This is another paper about reward behavior where the authors show the dynamic nature of chemical signaling in the NAc during intracranial selfstimulation and provide new insight into the role of NAc dopamine in reward-related behaviors. They measured the dynamic fluctuations in extracellular dopamine with fast-scan cyclic voltammetry. URLs: Besides pubmed and the various journals’ websites, here is a list of some other websites: http://www.standardbase.com/tech/FinalHUTechVolt.pdf - A great summary of voltammetry that goes over the history of introducing it all the way until talking about instrumentation and the basic setup. http://www.cheng.cam.ac.uk/research/groups/electrochem/teaching.html - Contains a general introduction to electrochemical measurements including voltammetry. It also introduces the ideas behind voltammetry and illustrate by animation how the concentration of reagents changes during the process. http://www.prenhall.com/settle/chapters/ch37.pdf - This is a very nice book that talks about voltammetric techniques enlisting the history of voltammetry, the instrumentations and the physics behind it. http://www.chem.uic.edu/chem421/ - A webpage that contains different lessons about electrochemistry, one of which is about voltammetry. I used it to understand the basics of voltammetry. http://www.cem.msu.edu/~cem333/ - Contains instrumentation analysis of many electrochemical techniques including voltammetry. http://www.kutztown.edu/acad/chem/instruments_html/electrochemistry.htm - This URL contains a very excellent explanation of the voltammetric technique showing all the essential components like the potentiostat, electrodes, and voltomograms. http://www.amelchem.com/download/items/voltammetry/manuals/eng/manual_eng.pdf - This is a great manual that goes into deep depth talking about everything that a person working with voltammetry should know. It is basically the company that sells the technique writing the manual. http://www.files.chem.vt.edu/chem-ed/echem/linsweep.html - This link introduces linear sweep voltammetry, a niece of cyclic scan voltammetry. The technique is the same, only ramping up the voltage defers. http://www.cheng.cam.ac.uk/research/groups/electrochem/JAVA/electrochemistry/ELEC/l 5html/cvr.html - This URL on the Cambridge website summarize the cyclic voltammetry technique and gives examples on how to use it for electrochemical purposes. http://www.consultrsr.com/resources/cv/cvsim.htm - A nice software that simulates cyclic voltammetry. It is free to download. .
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