Methadone Maintenance Treatment: Client Handbook
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PCSS Guidance: Transfer from Methadone to Buprenorphine
PCSS Guidance Topic: Transfer from Methadone to Buprenorphine Original Author: Paul P. Casadonte, M.D. Last Updated: 12/5/13 (Maria A. Sullivan, M.D., Ph.D.) Guideline Coverage: TIP #40, Treatment Protocols: Patients dependent on long-acting opioids (pgs. 52-54) Clinical Questions: 1. Which patients receiving methadone should be considered good candidates for transfer to buprenorphine? 2. How should I transition a patient from methadone to buprenorphine? Background: Patients receiving methadone may seek transfer to buprenorphine treatment. There are a large number of clinical scenarios that would cause a patient receiving methadone to seek induction onto buprenorphine. It is incumbent upon the physician to weigh the clinical issues carefully prior to agreeing to assist in the transfer. If a patient is stable on methadone, it is generally not advisable to agree to transfer to buprenorphine without a careful evaluation of the factors motivating the desire to transfer. However, if in the physician's medical judgment, buprenorphine treatment is appropriate and the patient is well-informed of the risks and benefits, transfer may be a reasonable option. Among the potential benefits of transfer to buprenorphine include lower risk of overdose or sedation, lower risk of QT prolongation and ventricular arrhythmias, less severe withdrawal if a dose is missed, the capacity to obtain medication at a local pharmacy and the option of treatment in a doctor's office. A number of factors might motivate a patient's request to transfer from methadone. These -
Fact Sheet on Methadone
Fact Sheet: Methadone Common Questions about Methadone • What is the typical dose of methadone and how is it taken? • How does someone know methadone is working? • How long does a person take methadone? • Who can prescribe methadone? • Can a person overdose on methadone? What is the typical dose of methadone and how is it taken? • Due to methadone’s slow and steady activation of opioid receptors, a person requires only one methadone dose per day. • Every person is different, and dosing should be individualized, based on a person’s experience of a reduction of withdrawal symptoms and cravings. • Most people start with an initial dose of 30-35 mg. It is then increased by 5mg every 3 days until a person experiences a relief from withdrawal symptoms.1 • Methadone is taken by mouth in a liquid form. • The recommended therapeutic (i.e., effective) dose of methadone is between 60 and 120 mg.1 How does someone know methadone is working? • The person will stop feeling withdrawal symptoms. • The person will also experience fewer cravings to use opioids. The intensity of their cravings will go down, but they may not completely go away.1 o Someone taking methadone may still have cravings to use other substances such as cocaine, benzodiazepines, alcohol, etc. The 3 Dimensions of Cravings: Frequency Duration Severity Number of separate times Once a craving starts, it Cravings range in a person starts to can range in how long it intensity, such as how experience a craving lasts at a high, distracting overwhelming, distracting, during the day. level. This could be and painful they feel. -
Methadone Hydrochloride Tablets, USP) 5 Mg, 10 Mg Rx Only
ROXANE LABORATORIES, INC. Columbus, OH 43216 DOLOPHINE® HYDROCHLORIDE CII (Methadone Hydrochloride Tablets, USP) 5 mg, 10 mg Rx Only Deaths, cardiac and respiratory, have been reported during initiation and conversion of pain patients to methadone treatment from treatment with other opioid agonists. It is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (see DOSAGE AND ADMINISTRATION). Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration. Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly in the early dosing period. These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration. In addition, cases of QT interval prolongation and serious arrhythmia (torsades de pointes) have been observed during treatment with methadone. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Methadone treatment for analgesic therapy in patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone is considered and outweighs the risks. Conditions For Distribution And Use Of Methadone Products For The Treatment Of Opioid Addiction Code of Federal Regulations, Title 42, Sec 8 Methadone products when used for the treatment of opioid addiction in detoxification or maintenance programs, shall be dispensed only by opioid treatment programs (and agencies, practitioners or institutions by formal agreement with the program sponsor) certified by the Substance Abuse and Mental Health Services Administration and approved by the designated state authority. -
Medications to Treat Opioid Use Disorder Research Report
Research Report Revised Junio 2018 Medications to Treat Opioid Use Disorder Research Report Table of Contents Medications to Treat Opioid Use Disorder Research Report Overview How do medications to treat opioid use disorder work? How effective are medications to treat opioid use disorder? What are misconceptions about maintenance treatment? What is the treatment need versus the diversion risk for opioid use disorder treatment? What is the impact of medication for opioid use disorder treatment on HIV/HCV outcomes? How is opioid use disorder treated in the criminal justice system? Is medication to treat opioid use disorder available in the military? What treatment is available for pregnant mothers and their babies? How much does opioid treatment cost? Is naloxone accessible? References Page 1 Medications to Treat Opioid Use Disorder Research Report Discusses effective medications used to treat opioid use disorders: methadone, buprenorphine, and naltrexone. Overview An estimated 1.4 million people in the United States had a substance use disorder related to prescription opioids in 2019.1 However, only a fraction of people with prescription opioid use disorders receive tailored treatment (22 percent in 2019).1 Overdose deaths involving prescription opioids more than quadrupled from 1999 through 2016 followed by significant declines reported in both 2018 and 2019.2,3 Besides overdose, consequences of the opioid crisis include a rising incidence of infants born dependent on opioids because their mothers used these substances during pregnancy4,5 and increased spread of infectious diseases, including HIV and hepatitis C (HCV), as was seen in 2015 in southern Indiana.6 Effective prevention and treatment strategies exist for opioid misuse and use disorder but are highly underutilized across the United States. -
Guidelines for Ketamine Use
St Joseph's Mercy Hospice Auckland NZ Guidelines for Ketamine Use Ketamine is a dissociative anaesthetic agent which has analgesic properties in sub- anaesthetic doses 1 Its principal site of action is in the dorsal horn of the spinal cord where it blocks the N-methyl D-aspartate (NMDA) receptor complex. Ketamine is used in palliative care settings primarily for neuropathic pain which is unresponsive or poorly responsive to first-line analgesics (which may include one or more of opioid drug, NSAID, tricyclic antidepressant, or anticonvusant) It has also been used for phantom limb and ischaemic pain and for intractable incident pain or prior to procedures such as dressing changes. Potential side effects Ketamine Routine use of ketamine is limited by its cost and potential side effects which may occur in up to 40% of patients; These may include: Psychotomimetic phenomena – “feeling strange” - dysphoria, vivid dreams, nightmares, hallucinations, altered body image. These effects may be minimised or treated by concurrent use of haloperidol or a benzodiazepine Delirium Hypertension, tachycardia Diplopia, nystagmus Erythema and pain at injection site Contraindications to ketamine use Ketamine has the potential to increase intra-cranial and intra-ocular pressures. It is contraindicated in patients with a history of hypertension, cerebrovascular disease or epilepsy and should be used with caution in patients with raised intra-cranial pressure and/or known cerebral metastases. Dosage regimens for Ketamine use 1. “Burst ketamine” 2 Ketamine is prescribed as a ‘burst’or ‘pulse’ course for a maximum of 5 days. The dose is titrated up, in a stepwise fashion, and once the lowest effective dose is achieved it is continued for 3 days at that dose then stopped. -
Methadone Therapy for Opioid Dependence LAURIE LIMPITLAW KRAMBEER, PH.D., WILLIAM VON MCKNELLY, JR., M.D., WILLIAM F
Methadone Therapy for Opioid Dependence LAURIE LIMPITLAW KRAMBEER, PH.D., WILLIAM VON MCKNELLY, JR., M.D., WILLIAM F. GABRIELLI, JR., M.D., PH.D. and ELIZABETH C. PENICK, PH.D. University of Kansas Medical Center, Kansas City, Kansas The 1999 Federal regulations extend the treatment options of methadone-maintained opi- oid-dependent patients from specialized clinics to office-based opioid therapy (OBOT). OBOT allows primary care physicians to coordinate methadone therapy in this group with ongo- ing medical care. This patient group tends to be poorly understood and underserved. Methadone maintenance therapy is the most widely known and well-researched treatment for opioid dependency. Goals of therapy are to prevent abstinence syndrome, reduce nar- cotic cravings and block the euphoric effects of illicit opioid use. In the first phase of methadone treatment, appropriately selected patients are tapered to adequate steady-state dosing. Once they are stabilized on a satisfactory dosage, it is often possible to address their other chronic medical and psychiatric conditions. The maintenance phase can be used as a long-term therapy until the patient demonstrates the qualities required for successful detox- ification. Patients who abuse narcotics have an increased risk for human immunodeficiency virus infection, hepatitis, tuberculosis and other conditions contributing to increased mor- bidity and mortality. Short- or long-term pain management problems and surgical needs are also common concerns in opioid-dependent patients and are generally treatable in conjunc- tion with methadone maintenance. (Am Fam Physician 2001;63:2404-10.) pioid dependence is a chronic, point in time.2,6,7 Gender differences exist, See editorial on page 2335. -
Methadone and the Anti-Medication Bias in Addiction Treatment
White, W. & Coon, B. (2003). Methadone and the anti-medication bias in addiction treatment. Counselor 4(5): 58-63. Methadone and the Anti-medication Bias in Addiction Treatment William L. White, MA and Brian F. Coon, MA, CADC An Introductory Note: This article is long overdue. Like many addiction counselors personally and professionally rooted in the therapeutic community and Minnesota model programs of the 1960s and 1970s, I exhibited a rabid animosity toward methadone and protected these beliefs in a shell of blissful ignorance. That began to change in the late 1970s when a new mentor, Dr. Ed Senay, gently suggested that the great passion I expressed on the subject of methadone seemed to be in inverse proportion to my knowledge about methadone. I hope this article will serve as a form of amends for that ignorance and arrogance. (WLW) There is a deeply entrenched anti-medication bias within the field of addiction treatment. This bias is historically rooted in the iatrogenic insults that have resulted from attempts to treat drug addiction with drugs. The most notorious of these professional practices includes: coaching alcoholics to substitute wine and beer for distilled spirits, treating alcoholism and morphine addiction with cocaine and cannabis, switching alcoholics from alcohol to morphine, failing repeatedly to find an alcoholism vaccine, employing aversive agents that linked alcohol or morphine to the experience of suffocation and treating alcoholism with drugs that later emerged as problems in their own right, e.g., barbiturates, amphetamines, tranquilizers, and LSD. A history of harm done in the name of good culturally and professionally imbedded a deep distrust of drugs in the treatment of alcohol and other drug addiction (White, 1998). -
1:03-Cv-03578 Document #: 199 Filed: 09/08/06 Page 1 of 136 Pageid
Case: 1:03-cv-03578 Document #: 199 Filed: 09/08/06 Page 1 of 136 PageID #:<pageID> IN THE UNITED STATES DISTRICT COURT FOR THE NORTHERN DISTRICT OF ILLINOIS EASTERN DIVISION FEDERAL TRADE COMMISSION, ) ) Plaintiff, ) Case No. 03 C 3578 ) v. ) Magistrate Judge Morton Denlow ) QT, INC., Q-RAY COMPANY, ) BIO-METAL, INC., QUE TE PARK, ) a.k.a. ANDREW Q. PARK, and ) JUNG JOO PARK, ) ) Defendants. ) MEMORANDUM OPINION AND ORDER “The pain just went away.” “Within seconds the pain was gone.” “You don’t have to live with pain.” The Q-Ray® Ionized Bracelet® (“Q-Ray bracelet”) achieved tremendous commercial success through a series of 30-minute infomercials. The Federal Trade Commission (“FTC”) brings this action claiming Defendants marketed the Q-Ray bracelet in a deceptive and misleading manner by representing that the bracelet provides immediate, significant or complete pain relief and scientific tests prove their pain-relief claims. Defendants deny their advertising was false or misleading. They contend adequate substantiation exists for the advertising claims made in connection with the promotion and sale of the Q-Ray bracelet. Case: 1:03-cv-03578 Document #: 199 Filed: 09/08/06 Page 2 of 136 PageID #:<pageID> The Court conducted a seven-day bench trial between June 6 and July 11, 2006. The Court has carefully considered the testimony of the witnesses who testified in person and by deposition, the Joint Stipulations of Fact for Trial, the exhibits introduced into evidence, the written submissions of the parties, and the oral arguments of counsel. The counsel on both sides presented the case in a highly professional manner. -
Defining Clinical Issues Around Tolerance, Hyperalgesia, And
ORIGINAL ARTICLE Defining clinical issues around tolerance, hyperalgesia, and addiction: A quantitative and qualitative outcome study of long-term opioid dosing in a chronic pain practice Jennifer P. Schneider, MD, PhD; Kenneth L. Kirsh, PhD ARTICLE INFO ABSTRACT Keywords: Treatment with opioid medications has grown over the past decades, but has been tolerance surrounded by some ongoing controversy and debate to whether it is causing more dependence opioids harm than good for patients. To this end, the field of pain management has suf- hyperalgesia fered from a lack of clarity about some basic definitions on concepts such as toler- long-term opioid therapy ance and hyperalgesia. Some characterize these issues as inevitable parts of opioid therapy while other schools of thought look at these issues as relatively rare occur- Article history: rences. Unfortunately, most of the rhetoric around these topics has occurred with Received 13 February 2010 very little in the realm of real world data. To this end, the authors have reviewed Received in revised form 26 July 2010; the charts of 197 patients treated by a pain specialist for at least 1 year to better 30 August 2010 Accepted 31 August 2010 illustrate whether notions of tolerance and hyperalgesia are common occurrences DOI:10.5055/jom.2010.0036 and, more importantly, whether they occur within any type of specified timeframe. A total of 197 patient charts were reviewed. The sample had an average age of 49.39 years (range ϭ 19-87 years; standard deviation [SD] ϭ 12.48) and com- prised 66 men (33.5 percent) and 131 women (66.5 percent). -
Evaluation of Need and Feasibility of Tuberculosis Screening in Buprenorphine Treatment Programs Ryan Schwarz
Yale University EliScholar – A Digital Platform for Scholarly Publishing at Yale Yale Medicine Thesis Digital Library School of Medicine January 2011 Evaluation Of Need And Feasibility Of Tuberculosis Screening In Buprenorphine Treatment Programs Ryan Schwarz Follow this and additional works at: http://elischolar.library.yale.edu/ymtdl Recommended Citation Schwarz, Ryan, "Evaluation Of Need And Feasibility Of Tuberculosis Screening In Buprenorphine Treatment Programs" (2011). Yale Medicine Thesis Digital Library. 1593. http://elischolar.library.yale.edu/ymtdl/1593 This Open Access Thesis is brought to you for free and open access by the School of Medicine at EliScholar – A Digital Platform for Scholarly Publishing at Yale. It has been accepted for inclusion in Yale Medicine Thesis Digital Library by an authorized administrator of EliScholar – A Digital Platform for Scholarly Publishing at Yale. For more information, please contact [email protected]. Evaluation of need and feasibility of tuberculosis screening in buprenorphine treatment programs A Thesis Submitted to the Yale University School of Medicine in Partial Fulfillment of the Requirements for the Degree of Doctor of Medicine by Ryan Schwarz Class of 2011 Table of Contents Acknowledgements .............................................................................................................................................. 3 Declaration of Interest ....................................................................................................................................... -
Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics
December 6, 2000 NIDA-CTN-0007 MOTIVATIONAL INCENTIVES FOR ENHANCED DRUG ABUSE RECOVERY: METHADONE CLINICS Maxine Stitzer, Ph.D., Lead Investigator Nancy Petry, Ph.D. Co-Lead Investigator Robert Brooner, Ph.D. Co-Investigator Jessica Peirce, Project Coordinator Protocol work group: Nancy Petry New England Paul McLaughlin New England Richard Rawson Pacific Frank Flammino Pacific Bob Forman Delaware Valley Peter Barbur Northwest Sara Lamb Northwest Scott Kellogg New York Elaine Pencer New York Jack Blaine NIDA NIDA-CTN-0007 Motivational Incentives: Methadone Clinic 1 Version 6, Date December 6, 2000 December 6, 2000 TABLE OF CONTENTS 1 LIST OF ABBREVIATIONS................................................................................................. 3 2 PROTOCOL SUMMARY...................................................................................................... 4 3 BACKGROUND AND SIGNIFICANCE.............................................................................. 7 4 STUDY OBJECTIVE........................................................................................................... 10 5 SUSTAINABILITY WITHIN THE CTP’S ........................................................................ 10 6 STUDY DESIGN.................................................................................................................. 11 6.1 Drug targets....................................................................................................................... 11 6.2 Bonus incentive targets: opiates....................................................................................... -
Marie Nyswanders Beitrag: Der Drogenabhängige Als Patient
SCHWERPUNKTTHEMA nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn S11 Marie Nyswanders Beitrag: Robert G. Newman Der Drogenabhängige als Patient Beth Israel Medical Center, New York, USA Zusammenfassung: Dieser Artikel schildert die besonderen Ein groûartiger Kollege, Josh von Soer Clemm von Hohenberg, Verdienste Mary Nyswanders in der Betrachtungsweise der der gebürtig aus den Niederlanden stammte, aber jahrelang Behandlung von Drogenabhängigen. Dabei spielte die Charak- in Hamburg lebte und auch dort arbeitete, hatte sein Leben terisierung des Drogenabhängigen als Patienten eine beson- der Hilfe all derer und ihrer Freunde und Angehörigen dere Rolle, nämlich in der Methadon-Erhaltungsbehandlung, gewidmet, die von Abhängigkeitserkrankungen betroffen die auf eine dauerhafte Behandlung und nicht auf vollständige sind. Ich muss gestehen, ich war sprachlos, als mich Josh und sofortige Heilung abzielt. damals anrief und mir mitteilte, dass seine jahrelangen eigenhändigen Bemühungen, Marie (die zehn Jahre zuvor Schlüsselwörter: Opiatabhängigkeit ± Ethische Probleme ± verstorben war) mit einer nach ihr zu Ehren benannten Methadon ± Substitutionsbehandlung ± Patientenbild Straûe Anerkennung zu zollen, schlieûlich von all den vielen dafür zuständigen Behörden genehmigt worden war. The Contribution of Marie Nyswander ± The Drug Addict Nirgends sonst auf der Welt gibt es eine vergleichbare as a Patient: This article describes the special contribution Anerkennung, weder für Marie noch für Vince Dole ± nicht in of Marie Nyswander's way of looking at the treatment of den USA, wo sie ihre Pionierarbeit leisteten und wo heute drug addicts. She focused on the characterization of the drug über 160000 Menschen Methadonbehandlungen erhalten; addict as a patient, namely in the methadone maintenance nicht in Hongkong, wo Heroinabhängigen seit über einem treatment, which aims at a long-lasting treatment and not at Vierteljahrhundert ein sofortiger Zugang (d.h.