Methadone WHAT IS METHADONE? Methadone Is a Synthetic (Man-Made) Narcotic

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Methadone WHAT IS METHADONE? Methadone is a synthetic (man-made) narcotic. WHAT IS ITS ORIGIN? German scientists synthesized methadone during World War II because of a shortage of morphine. Methadone was introduced into the United States in 1947 as an analgesic (Dolophine®). What are common street names? Common street names include: • Amidone, Chocolate Chip Cookies, Fizzies with MDMA, and Wafer Methadone What does it look like? Methadone is available as a tablet, oral solution, itchy skin, or sleepiness. Individuals who abuse or injectable liquid. Tablets are available in 5 mg methadone risk becoming tolerant of and and 10 mg formulations. As of January 1, 2008, physically dependent on the drug. manufacturers of methadone hydrochloride When use is stopped, individuals may tablets 40 mg (dispersible) have voluntarily experience withdrawal symptoms including: agreed to restrict distribution of this formulation to • Anxiety, muscle tremors, nausea, diarrhea, vomiting, and only those facilities authorized for detoxification abdominal cramps and maintenance treatment of opioid addiction, and hospitals. Manufacturers will instruct their What are its overdose effects? wholesale distributors to discontinue supplying this The effects of a methadone overdose are: formulation to any facility not meeting the above • Slow and shallow breathing, blue fingernails and lips, criteria. stomach spasms, clammy skin, convulsions, weak pulse, coma, and possible death How is it abused? Methadone can be swallowed or injected. Which drugs cause similar effects? Although chemically unlike morphine or heroin, What is its effect on the mind? methadone produces many of the same effects. Abuse of methadone can lead to psychological dependence. What is its legal status in the United States? Methadone is a Schedule II drug under the What is its effect on the body? Controlled Substances Act. While it may legally be When an individual uses methadone, he/she may used under a doctor’s supervision, its non-medical experience physical symptoms like sweating, use is illegal..

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Fact Sheet on Methadone
Fact Sheet: Methadone Common Questions about Methadone • What is the typical dose of methadone and how is it taken? • How does someone know methadone is working? • How long does a person take methadone? • Who can prescribe methadone? • Can a person overdose on methadone? What is the typical dose of methadone and how is it taken? • Due to methadone’s slow and steady activation of opioid receptors, a person requires only one methadone dose per day. • Every person is different, and dosing should be individualized, based on a person’s experience of a reduction of withdrawal symptoms and cravings. • Most people start with an initial dose of 30-35 mg. It is then increased by 5mg every 3 days until a person experiences a relief from withdrawal symptoms.1 • Methadone is taken by mouth in a liquid form. • The recommended therapeutic (i.e., effective) dose of methadone is between 60 and 120 mg.1 How does someone know methadone is working? • The person will stop feeling withdrawal symptoms. • The person will also experience fewer cravings to use opioids. The intensity of their cravings will go down, but they may not completely go away.1 o Someone taking methadone may still have cravings to use other substances such as cocaine, benzodiazepines, alcohol, etc. The 3 Dimensions of Cravings: Frequency Duration Severity Number of separate times Once a craving starts, it Cravings range in a person starts to can range in how long it intensity, such as how experience a craving lasts at a high, distracting overwhelming, distracting, during the day. level. This could be and painful they feel.
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Methadone and the Anti-Medication Bias in Addiction Treatment
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REVIEW ARTICLE Anesthesiology 2010; 113:977–92 Copyright © 2010, the American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins Smoking and Pain Pathophysiology and Clinical Implications Yu Shi, M.D., M.P.H.,* Toby N. Weingarten, M.D.,† Carlos B. Mantilla, M.D., Ph.D.,‡ W. Michael Hooten, M.D.,† David O. Warner, M.D.§ ABSTRACT to deliver nicotine. Nicotine has analgesic properties, first Cigarette smoke, which serves as a nicotine delivery vehicle observed in feline visceral pain models3 and since then rep- in humans, produces profound changes in physiology. Ex- licated in numerous animal and human studies.4–13 Its anal- perimental studies suggest that nicotine has analgesic prop- gesic effects likely result from effects at both central and erties. However, epidemiologic evidence shows that smoking peripheral nicotine acetylcholine receptors (nAChRs).8,14,15 is a risk factor for chronic pain. The complex relationship Other nAChR ligands also have potent analgesic effects.16–20 between smoking and pain not only is of scientific interest, On the other hand, clinical evidence suggests that smokers but also has clinical relevance in the practice of anesthesiol- are at increased risk of developing back pain and other ogy and pain medicine. This review will examine current chronic pain disorders.21–32 Furthermore, comparisons be- knowledge regarding how acute and chronic exposure to nic- tween smokers and nonsmokers with chronic pain disorders otine and cigarette smoke affects acute and chronic painful have repeatedly demonstrated
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(19) TZZ ZZ_Z_T (11) EP 2 200 610 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/4468 (2006.01) A61P 25/00 (2006.01) 10.01.2018 Bulletin 2018/02 (86) International application number: (21) Application number: 08831500.7 PCT/US2008/077139 (22) Date of filing: 19.09.2008 (87) International publication number: WO 2009/039460 (26.03.2009 Gazette 2009/13) (54) CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS COADMINISTRATION VON PIMAVANSERIN MIT ANDEREN MITTELN CO-ADMINISTRATION DE PIMAVANSÉRINE AVEC D’AUTRES AGENTS (84) Designated Contracting States: • MCFARLAND, Krista AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Walnut Creek, CA 94597 (US) HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (74) Representative: Savic, Bojan et al Designated Extension States: Jones Day AL BA MK RS Rechtsanwälte Attorneys-at-Law Patentanwälte Prinzregentenstraße 11 (30) Priority: 21.09.2007 US 974426 P 80538 München (DE) 07.11.2007 US 986250 P 06.05.2008 US 50976 (56) References cited: EP-A1- 1 576 985 WO-A-2004/064738 (43) Date of publication of application: WO-A-2005/112927 US-A1- 2005 261 340 30.06.2010 Bulletin 2010/26 Remarks: (73) Proprietor: Acadia Pharmaceuticals Inc. Thefile contains technical information submitted after San Diego, CA 92139 (US) the application was filed and not included in this specification (72) Inventors: • HACKSELL, Uli Tampa, FL 33639 (US) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations.
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