Emerging Drug Trends 2014
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Basic Course Unit Guide
If you have issues viewing or accessing this file contact us at NCJRS.gov. i i I ! , i BASIC COURSE I UNIT GUIDE JjI ( 12 ) C___________ C_O_N_TR_O_L_L_E_D_S_U_B_S_T_A_NC_E_S ___________ ) ; ! This unit guide covers the following performance objectives containe i I in Performance Objectives/or the POST Basic Course: 3.31.1 3.32.1 3.32.6 3.32.11 3.34.1 3.31.2 3.32.2 3.32.7 3.33.2 3.34.2 3.31.3 3.32.3 3.32.8 3.33.3 3.35.1 3.31.4 3.32.4 3.32.9 3.33.5 • I I 3.31.5 3.32.5 3.32.10 3.33.6 , I I Ii I i 11 I ___--Ii ;. : THE COMMISSION (/ ON PEACE OFFICER STANDARDS AND TRAINltJA • STAU OF CA1.IFORNBA • This unit of Instruction Is designed as a guideline for performance obJective-based law enforcement basic training. H Is part of the POST Basic Course guidelines system developed by California law enforcement trainers and criminal Justice educators for the California Commission on Peace Officer Standards and Training. This guide Is designed to assist the Instructor In developing an approprlat~ lesson plan to cover the performance objectives which are required as minimum content of the Basic Course. • 140188 U.S. Department of Justice Natlonallnstltute of Justice This document has been reproduced exactly as received from t~e parson or organization originating It. Points of view or opinions stated 10 this document are those of the authors and do not necessarily represent the official position or po\lcl~ of the National Institute of Justice. -
Fact Sheet on Methadone
Fact Sheet: Methadone Common Questions about Methadone • What is the typical dose of methadone and how is it taken? • How does someone know methadone is working? • How long does a person take methadone? • Who can prescribe methadone? • Can a person overdose on methadone? What is the typical dose of methadone and how is it taken? • Due to methadone’s slow and steady activation of opioid receptors, a person requires only one methadone dose per day. • Every person is different, and dosing should be individualized, based on a person’s experience of a reduction of withdrawal symptoms and cravings. • Most people start with an initial dose of 30-35 mg. It is then increased by 5mg every 3 days until a person experiences a relief from withdrawal symptoms.1 • Methadone is taken by mouth in a liquid form. • The recommended therapeutic (i.e., effective) dose of methadone is between 60 and 120 mg.1 How does someone know methadone is working? • The person will stop feeling withdrawal symptoms. • The person will also experience fewer cravings to use opioids. The intensity of their cravings will go down, but they may not completely go away.1 o Someone taking methadone may still have cravings to use other substances such as cocaine, benzodiazepines, alcohol, etc. The 3 Dimensions of Cravings: Frequency Duration Severity Number of separate times Once a craving starts, it Cravings range in a person starts to can range in how long it intensity, such as how experience a craving lasts at a high, distracting overwhelming, distracting, during the day. level. This could be and painful they feel. -
“Ecstasy” Tablets
Department of Alcohol & OSAM-O-GRAM Drug Addiction Services Wright State University Dateline: Ohio June 2008-January 2009 Statewide reports of piperazines in adulterated “Ecstasy” tablets Increases in Piperazine Availability surfaced in northeast Ohio, “We did just see one with mCPP, but In January 2008, the OSAM Network received initial reports that’s not as popular as BZP. The informant who brought it was told it was from crime lab professionals of piperazine-containing pressed ‘Triple E’ or ‘Super Ecstasy’ by the dealer. Most of the tablets don’t look tablets that appeared to be sold as Ecstasy. One year later, any different than Ecstasy but we did find one micro tablet, which was half availability of pressed tablets containing piperazines has the size of a normal Ecstasy tablet and it ended up being mCPP.” A lab drastically increased throughout the state (Table below). in the central Ohio area reported most of the pressed tablets Piperazine cases now outnumber the cases of MDMA- analyzed there contain polydrug combinations, “The most common containing Ecstasy tablets analyzed by crime labs across Ohio. combination in our lab is BZP/TFMPP/MDMA/Methamphetamine. A crime lab professional from the central Ohio area said, “We In the last year, only seven cases have been BZP alone.” analyzed our first benzylpiperazine cases in January 2008, and it’s been fairly steady since that time.” Piperazines vs. Ecstasy(MDMA) Crime lab professionals reported piperazines are indistinguishable Table 1: Availability of piperazine tablets according to crime from traditional Ecstasy tablets. A crime lab professional from lab professionals the northwest Ohio area noted, “Most lab chemists would tell you just Jan. -
Legal Party Pills and Their Use by Young People in New Zealand: a Qualitative Study
LEGAL PARTY PILLS AND THEIR USE BY YOUNG PEOPLE IN NEW ZEALAND: A QUALITATIVE STUDY FINAL REPORT OF FINDINGS First submitted December 2006 Revised June 2007 Janie Sheridan, PhD MRPharmS, MPS(NZ), BPharm(Hons), BA(Hons) Rachael Butler, BA The School of Pharmacy The University of Auckland New Zealand i Suggested citation: Sheridan, J. & Butler, R. (2007) Legal party pills and their use by young people in New Zealand: a qualitative study. Final report of findings (revised June 2007). University of Auckland: Auckland ii TABLE OF CONTENTS Acknowledgements.................................................................................................................. v Glossary................................................................................................................................... vi Executive Summary of Results............................................................................................. vii 1.0 Introduction ....................................................................................................................... 1 1.1 Structure of this report .........................................................................................1 1.2 Background literature...........................................................................................1 1.3 Rationale for researching young people’s use of party pills................................4 2.0 Study Aims ......................................................................................................................... 6 3.0 Methods -
Methadone Hydrochloride Tablets, USP) 5 Mg, 10 Mg Rx Only
ROXANE LABORATORIES, INC. Columbus, OH 43216 DOLOPHINE® HYDROCHLORIDE CII (Methadone Hydrochloride Tablets, USP) 5 mg, 10 mg Rx Only Deaths, cardiac and respiratory, have been reported during initiation and conversion of pain patients to methadone treatment from treatment with other opioid agonists. It is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (see DOSAGE AND ADMINISTRATION). Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration. Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly in the early dosing period. These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration. In addition, cases of QT interval prolongation and serious arrhythmia (torsades de pointes) have been observed during treatment with methadone. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Methadone treatment for analgesic therapy in patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone is considered and outweighs the risks. Conditions For Distribution And Use Of Methadone Products For The Treatment Of Opioid Addiction Code of Federal Regulations, Title 42, Sec 8 Methadone products when used for the treatment of opioid addiction in detoxification or maintenance programs, shall be dispensed only by opioid treatment programs (and agencies, practitioners or institutions by formal agreement with the program sponsor) certified by the Substance Abuse and Mental Health Services Administration and approved by the designated state authority. -
Medications to Treat Opioid Use Disorder Research Report
Research Report Revised Junio 2018 Medications to Treat Opioid Use Disorder Research Report Table of Contents Medications to Treat Opioid Use Disorder Research Report Overview How do medications to treat opioid use disorder work? How effective are medications to treat opioid use disorder? What are misconceptions about maintenance treatment? What is the treatment need versus the diversion risk for opioid use disorder treatment? What is the impact of medication for opioid use disorder treatment on HIV/HCV outcomes? How is opioid use disorder treated in the criminal justice system? Is medication to treat opioid use disorder available in the military? What treatment is available for pregnant mothers and their babies? How much does opioid treatment cost? Is naloxone accessible? References Page 1 Medications to Treat Opioid Use Disorder Research Report Discusses effective medications used to treat opioid use disorders: methadone, buprenorphine, and naltrexone. Overview An estimated 1.4 million people in the United States had a substance use disorder related to prescription opioids in 2019.1 However, only a fraction of people with prescription opioid use disorders receive tailored treatment (22 percent in 2019).1 Overdose deaths involving prescription opioids more than quadrupled from 1999 through 2016 followed by significant declines reported in both 2018 and 2019.2,3 Besides overdose, consequences of the opioid crisis include a rising incidence of infants born dependent on opioids because their mothers used these substances during pregnancy4,5 and increased spread of infectious diseases, including HIV and hepatitis C (HCV), as was seen in 2015 in southern Indiana.6 Effective prevention and treatment strategies exist for opioid misuse and use disorder but are highly underutilized across the United States. -
The Opioid Epidemic: What Labs Have to Do with It?
The Opioid Epidemic: What labs have to do with it? Ewa King, Ph.D. Associate Director of Health RIDOH State Health Laboratories Analysis. Answers. Action. www.aphl.org Overview • Overdose trends • Opioids and their effects • Analytical testing approaches • Toxicology laboratories Analysis. Answers. Action. www.aphl.org Opioid overdose crisis 1 Analysis. Answers. Action. www.aphl.org Opioid overdose crisis 2 Analysis. Answers. Action. www.aphl.org Opiates and Opioids • Opiates vs. Opioids • Opiates: Naturally occurring, derived from the poppy plant • Opioids: “Opiate-like” drugs in effects, not chemical structure Includes opiates • Narcotic analgesics • CNS depressants • DEA Schedule I or II controlled substances • Additive effect with other CNS depressant drugs Analysis. Answers. Action. www.aphl.org Efficacy of Opioids • How do opioids work? • Bind with opioid receptors • Brain, spinal cord, GI tract, and throughout the body • Pain, emotion, breathing, movement, and digestion Opioid Receptor Analysis. Answers. Action. www.aphl.org Effects of Opioids Physiological Psychological • Pain relief • Drowsiness/ sedation • Cough suppression • Mental confusion • GI motility • Loss of memory • Respiratory depression • Lethargy/ apathy • Pupillary constriction • Euphoria/ tranquility • Itching • Mood swings • Constipation • Depression • Dependence • Withdrawal • Dependence Analysis. Answers. Action. www.aphl.org Opiates 1 Opiates • Naturally occurring alkaloids Opium • Latex from the opium poppy plant Codeine: • Mild to moderate pain • Antitussive Morphine: • Severe pain • Metabolite of codeine and heroin Analysis. Answers. Action. www.aphl.org Opiates 2 Semi-synthetic Opiates: • Synthesized from a natural opiate Heroin: • Schedule I narcotic Hydrocodone (Vicodin): • Mild to moderate pain • Metabolizes to hydromorphone (Dilaudid) Oxycodone (Oxycontin/Percocet): • Moderate to severe pain • Metabolizes to oxymorphone (Opana) Analysis. Answers. Action. -
Quantitative Drug Test Menu Section 2
1 Guthrie Square, Sayre, PA 18840 Bill To: Client GMG Toxicology Laboratory Requisition Toll Free Phone (844) 617-4719 Insurance Request Date: _____/______/______ Medical Director: Hani Hojjati, MD Fax (570) 887-4729 Patient PATIENT INFORMATION (PLEASE PRINT IN BLACK INK) INSURANCE BILLING INFORMATION (PLEASE PRINT IN BLACK INK) Pt Last Name First M I PRIMARY Medicare Medicaid Other Ins. Self Spouse Child __ Subscriber Last Name First M Address Birth Date Sex M F Beneficiary/Member # Group # City Pt. SS# or MRN Claims Name and Address City ST ZIP ST ZIP Home Phone (Attach a copy of the patient's insurance card and information) SECONDARY Medicare Medicaid Other Ins. Self Spouse Child Employer Work Phone Subscriber Last Name First M Work Address City ST ZIP Beneficiary/Member # Group # __ CLIENT INFORMATION - REFERRING PHYSICIAN Claims Name and Address City ST ZIP Client Address: (Atttach a copy of the patient's insurance card and information) COLLECTION / REPORTING INFORMATION Copy to: FAX Results to __ CALL Results to Phone: Fax: Date Collected: Time Collected: AM PM Specimen Type: Urine Saliva Other ___________________ Physician Signature (legible - No Stamp) For Lab Use Only (Required for Medicare & Medicaid patient orders) Signed ABN Obtained Place Lab Label Here Contact Laboratory Medical Director (570-887-4719) with questions concerning medical necessity PHYSICIAN When ordering tests, the physician is required to make an independent medical necessity decision with regard to each test thelaboratory will bill. The physician also understands he or she is required NOTICE to (1) submit ICD-10 diagnosis supported in the patient's medical record as documentation of the medical necessity or (2) explain and have the patient sign an ABN. -
Guidelines for Ketamine Use
St Joseph's Mercy Hospice Auckland NZ Guidelines for Ketamine Use Ketamine is a dissociative anaesthetic agent which has analgesic properties in sub- anaesthetic doses 1 Its principal site of action is in the dorsal horn of the spinal cord where it blocks the N-methyl D-aspartate (NMDA) receptor complex. Ketamine is used in palliative care settings primarily for neuropathic pain which is unresponsive or poorly responsive to first-line analgesics (which may include one or more of opioid drug, NSAID, tricyclic antidepressant, or anticonvusant) It has also been used for phantom limb and ischaemic pain and for intractable incident pain or prior to procedures such as dressing changes. Potential side effects Ketamine Routine use of ketamine is limited by its cost and potential side effects which may occur in up to 40% of patients; These may include: Psychotomimetic phenomena – “feeling strange” - dysphoria, vivid dreams, nightmares, hallucinations, altered body image. These effects may be minimised or treated by concurrent use of haloperidol or a benzodiazepine Delirium Hypertension, tachycardia Diplopia, nystagmus Erythema and pain at injection site Contraindications to ketamine use Ketamine has the potential to increase intra-cranial and intra-ocular pressures. It is contraindicated in patients with a history of hypertension, cerebrovascular disease or epilepsy and should be used with caution in patients with raised intra-cranial pressure and/or known cerebral metastases. Dosage regimens for Ketamine use 1. “Burst ketamine” 2 Ketamine is prescribed as a ‘burst’or ‘pulse’ course for a maximum of 5 days. The dose is titrated up, in a stepwise fashion, and once the lowest effective dose is achieved it is continued for 3 days at that dose then stopped. -
01012100 Pure-Bred Horses 0 0 0 0 0 01012900 Lives Horses, Except
AR BR UY Mercosu PY applied NCM Description applied applied applied r Final Comments tariff tariff tariff tariff Offer 01012100 Pure-bred horses 0 0 0 0 0 01012900 Lives horses, except pure-bred breeding 2 2 2 2 0 01013000 Asses, pure-bred breeding 4 4 4 4 4 01019000 Asses, except pure-bred breeding 4 4 4 4 4 01022110 Purebred breeding cattle, pregnant or lactating 0 0 0 0 0 01022190 Other pure-bred cattle, for breeding 0 0 0 0 0 Other bovine animals for breeding,pregnant or 01022911 lactating 2 2 2 2 0 01022919 Other bovine animals for breeding 2 2 2 2 4 01022990 Other live catlle 2 2 2 2 0 01023110 Pure-bred breeding buffalo, pregnant or lactating 0 0 0 0 0 01023190 Other pure-bred breeding buffalo 0 0 0 0 0 Other buffalo for breeding, ex. pure-bred or 01023911 pregnant 2 2 2 2 0 Other buffalo for breeding, except pure-bred 01023919 breeding 2 2 2 2 4 01023990 Other buffalos 2 2 2 2 0 01029000 Other live animals of bovine species 0 0 0 0 0 01031000 Pure-bred breedig swines 0 0 0 0 0 01039100 Other live swine, weighing less than 50 kg 2 2 2 2 0 01039200 Other live swine, weighing 50 kg or more 2 2 2 2 0 01041011 Pure-bred breeding, pregnant or lactating, sheep 0 0 0 0 0 01041019 Other pure-bred breeding sheep 0 0 0 0 0 01041090 Others live sheep 2 2 2 2 0 01042010 Pure-bred breeding goats 0 0 0 0 0 01042090 Other live goats 2 2 2 2 0 Fowls spec.gallus domestic.w<=185g pure-bred 01051110 breeding 0 0 0 0 0 Oth.live fowls spec.gall.domest.weig.not more than 01051190 185g 2 2 2 2 0 01051200 Live turkeys, weighing not more than 185g 2 2 -
National Vital Statistics Report: Drugs Most Frequently Involved In
National Vital Statistics Reports Volume 67, Number 9 December 12, 2018 Drugs Most Frequently Involved in Drug Overdose Deaths: United States, 2011–2016 by Holly Hedegaard, M.D., M.S.P.H., and Brigham A. Bastian, B.S., National Center for Health Statistics; James P. Trinidad, M.P.H., M.S., U.S. Food and Drug Administration; Merianne Spencer, M.P.H., and Margaret Warner, Ph.D., National Center for Health Statistics Abstract overdose deaths involving methadone decreased from 1.4 per 100,000 in 2011 to 1.1 in 2016. The 10 most frequently Objective—This report identifies the specific drugs involved mentioned drugs often were found in combination with each most frequently in drug overdose deaths in the United States other. The drugs most frequently mentioned varied by the intent from 2011 through 2016. of the drug overdose death. In 2016, the drugs most frequently Methods—Record-level data from the 2011–2016 National mentioned in unintentional drug overdose deaths were fentanyl, Vital Statistics System–Mortality files were linked to electronic heroin, and cocaine, while the drugs most frequently mentioned files containing literal text information from death certificates. in suicides by drug overdose were oxycodone, diphenhydramine, Drug overdose deaths were identified using the International hydrocodone, and alprazolam. Classification of Diseases, Tenth Revision underlying cause- Conclusions—This report identifies patterns in the specific of-death codes X40–X44, X60–X64, X85, and Y10–Y14. Drug drugs most frequently involved in drug overdose deaths from mentions were identified by searching the literal text in three 2011 through 2016 and highlights the importance of complete fields of the death certificate: the causes of death from Part I, and accurate reporting in the literal text on death certificates. -
Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate.