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Columbia 2018 ANNUAL REPORT Financially Speaking A future without Medicine medical school debt Columbia University Vagelos College of Physicians & Surgeons Precision Medicine Moving data to patient care MEDICINE PRESENT & FUTURE TECHNOLOGY FROM ACADEMIC MEDICINE IS DRIVING NEW TREATMENTS TO PATIENTS NOW Features: 4 10 16 Revving Up Precision Medicine: What Financial Medical Research Promise (Being) Freedom Means as Innovation Fulfilled to Tomorrow’s Engine Minimizing “variants of Doctors Researchers are using unknown significance” is Five VP&S alumni discuss technology transfer, one of the goals of precision how scholarships shaped their robotics, phone apps, and medicine research, and careers amid news that future other technology to identify mining data from a more generations of graduates will treatments for diabetes, diverse population—the benefit from the generosity Alzheimer’s, cancer, and goal of the federal All of Us of Diana and Roy Vagelos’54 infectious diseases. What was Research Program—will and others who have made once the domain of industry speed that goal. Already, it possible for students with is now considered a routine precision medicine shows financial need to get through part of academic medicine promise in diagnosing medical school without research, and Columbia some patients thought to borrowing money. offers tools to help faculty have schizophrenia with a move their innovations to virus instead and offering the marketplace. new treatments for thyroid problems and sarcoma. http://ps.columbia.edu/ ColumbiaMedicine | 2018 Annual Report Issue Departments: 2 Dean’s Message 22 2018 Year in Highlights 30 Philanthropy News 34 VP&S News 39 About VP&S · Trustees Committee on the Health Sciences · CUIMC Board of Advisors · Other CUIMC Advisory Groups · CUIMC Administration · Vagelos College of Physicians & Surgeons Administration · Executive Committee of the Faculty Council · Department Chairs · University Centers and Institutes and Directors · Affiliated Hospitals · Facts and Statistics On the Cover New drugs and other innovations that can benefit patients are 20 increasingly coming out of the work done in medical school labs. With the help of Columbia Technology Ventures and other systems, Righting a Wrong: VP&S researchers can identify collaborators to move their ideas to David McDonogh, commercial use, learn how to file for patents, get tips on how to launch Denied Degree in their own companies, or find other support necessary to move their discoveries along the path of commercialization. Story, Page 4. 1800s, Receives Illustration by Benedetto Cristofani. Posthumous MD When we discovered that 2018 Annual Report Office of the Chief Executive and David McDonogh, a black Editor: Bonita Eaton Enochs Dean of the Faculties of medical student at VP&S in Health Sciences and Medicine the 1840s, was not officially Principal Writer: Sharon Tregaskis Columbia University Irving Medical Center Contributing Writers: recognized as a student or 630 W. 168th St. Avichai Assouline, Susan Conova, graduate, we were determined New York, NY 10032 Alla Katsnelson, Joseph Neighbor, to right a 171-year-old wrong. Odelia Ghodsizadeh Dr. McDonogh, who completed Communications Office Art Director: Eson Chan his studies in 1847, received Vagelos College of Physicians & Surgeons 701 W. 168th St., Box 153 his posthumous MD diploma Produced by the Communications New York, NY 10032 from Columbia at the 2018 Office at Columbia University Phone: 212-305-3900 Vagelos College of graduation ceremony, and a Fax: 212-305-4521 scholarship in his name will Physicians & Surgeons Christopher DiFrancesco, help other students who have Office of Development Chief Communications Officer overcome adversity. Columbia University Irving Medical Center Printed in September 2018 630 W. 168th St., P&S 2-421 New York, NY 10032 Phone: 212-342-0088 • DEAN’S MESSAGE The Year That Rang Out the Old and Rang In the Next 250 Years he year during which we celebrated our 250th The stories in this report reflect the best of a year anniversary celebration can be summed up in a that has been punctuated by remarkable headlines. T remarkable comparison: We started the year as A gift from the estate of Herbert Irving, who died in the College of Physicians and Surgeons at the Colum- 2016, and Florence Irving, who died earlier this year, bia University Medical Center, and we had two Nobel enabled us to join with NewYork-Presbyterian Hospital Prize winners on our active faculty. We finished the year to rename our shared campus the Columbia University JÖRG MEYER as the Vagelos College of Physicians and Surgeons at Irving Medical Center. The naming is a fitting tribute Columbia University Irving Medical Center—and we to the Irvings, whose friendship and philanthropy have had three Nobel Prize winners on our active faculty. long supported our cancer programs and many other The 2017-18 year was not only a celebration of our programs, including the work of junior and senior legacy in medical education, research, and patient care researchers. They also tirelessly championed the great but also a time for thoughtful planning that will ensure care they received from Columbia physicians. our continued leadership in academic medicine. By devel- We also rededicated the medical school by chang- oping new programs, establishing new departments, ing our name to the Roy and Diana Vagelos College recruiting renowned faculty, and growing our research of Physicians and Surgeons—VP&S. This new name portfolio, we are building the future of a medical school aligns the school with a name that has long symbol- that has not just survived for 250 years but has thrived ized ingenuity, leadership, vision, and generosity. For over 10 generations of organizational changes, shifts in example, this year the Prix Galien USA Committee Three Nobelists: Richard Axel, Joachim societal norms, and technology that continues to shape renamed its award for individual service to improve Frank, and Eric Kandel how we learn, study disease, and advance patient care. the state of human health as the “Roy Vagelos Pro Bono Humanum Award for Global Health Equity” in recognition of his historic act of moral leadership while CEO of Merck in donating ivermectin to treat and prevent river blindness in 34 countries. Roy and Diana Vagelos not only lent us their name, they generously provided a scholarship endowment that was then supplemented by more than $25 mil- lion in matching gifts from generous alumni, faculty, and friends who responded to the couple’s challenge to support this worthy effort. Starting this August, the endowment allowed us to eliminate loans and instead to provide scholarships for all of our medical students who have financial need. The scholarship program funded by these gifts will make VP&S affordable to all, and it will enable our graduates to pursue their professional dreams without being encumbered by repayment of medical school loans. At graduation this year, we honored a man who completed his studies at VP&S 171 years earlier. David Kearney McDonogh was born an enslaved person in New Orleans and after he became a free man by attending college in Pennsylvania, he started medical studies with a mentor at Columbia. Because of his color, however, he was never formally recog- 2 ColumbiaMedicine nized as a student let alone allowed to graduate. We rectified that wrong by giving him a posthumous MD degree, which we presented to Patricia Worthy, Dr. McDonogh’s great-great-granddaughter, at our gradu- ation ceremony in May. You can read more about Dr. McDonogh’s life and work inside this report. In research, Joachim Frank, PhD, shared the 2017 Nobel Prize in Chemistry for his groundbreaking work creating and applying cryo-electron microscopy. He joins Eric Kandel, MD, and Richard Axel, MD, as our three Nobel Laureates on the active VP&S faculty. We also can boast of our rapidly growing NIH funding. Columbia is the only leading medical school to exceed the change in the NIH budget for eight consecutive years. During that time, VP&S has had the second largest absolute increase in NIH funding mented. This large undertaking, years in the making, of any medical school in the nation—a testament to will greatly benefit patients and clinicians. Columbia President Lee Bollinger, left, the rigorous basic and clinical research done by our These technical and programmatic innovations will and VP&S Dean Lee renowned faculty. help us build on our future as educators, caregivers, Goldman, right, with One large award from the NIH supports our part and investigators, but we also know the importance Roy and Diana Vagelos of the national precision medicine initiative, the All of our physical infrastructure. A full year of enjoying of Us Research Program, which has great potential to our new Vagelos Education Center building, which improve the health of many by gathering genetic infor- still turns heads on Haven Avenue, was followed by mation from individual volunteers across the full spec- renovation of our Alumni Auditorium, another facility trum of American life. We are proud to lead the New that is enjoyed as a shared space by many in our neigh- York consortium and grateful for the many members borhood. By next summer, Haven Plaza, a pedestrian of Upper Manhattan who have committed to partici- area created by closing the block of Haven Avenue, pating in this important endeavor. off Fort Washington Avenue, will offer a vibrant space In education, we launched two new departments this for everyone in our community and the surrounding year: the Department of Emergency Medicine, chaired neighborhood to use—to relax, enjoy a meal or a con- by Angela Mills, MD, whom we recruited from the versation with a friend, participate in arts and cultural University of Pennsylvania, and the Department of activities, or shop at the weekly greenmarket. Medical Humanities and Ethics, chaired by longtime faculty member Rita Charon, MD, PhD, founder of ur historic 250th year was one of great accom- the field of narrative medicine.