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Skinny and 119 Pounds, but with the Health Hallmarks of Obesity - the New York Times 7/22/16, 2:42 PM
Skinny and 119 Pounds, but With the Health Hallmarks of Obesity - The New York Times 7/22/16, 2:42 PM http://nyti.ms/2aeHHnQ Skinny and 119 Pounds, but With the Health Hallmarks of Obesity A small group of thin patients who develop disorders typically tied to obesity pose a medical mystery and a potential opportunity for scientists. By GINA KOLATA JULY 22, 2016 Claire Walker Johnson of Queens was a medical mystery. No matter how much she ate, she never gained weight. And yet Ms. Johnson, with a long narrow face, had the conditions many obese people develop — Type 2 diabetes, high blood pressure, high cholesterol and, most strikingly, a liver buried in fat. She and a very small group of very thin people like her have given scientists surprising clues to one of the most important questions about obesity: Why do fat people often develop serious and sometimes life-threatening medical conditions? The answer, it turns out, has little to do with the fat itself. It’s about each person’s ability to store it. With that understanding, scientists are now working on drug treatments to protect people from excess unstored fat and spare them from dire medical conditions. The need is clear. One in three Americans and one in four adults worldwide have at least three conditions associated with obesity such as diabetes, high cholesterol and high blood pressure — a combination of disorders that doubles their risk of heart attacks and strokes. In addition, 2 percent to 3 percent of adults http://www.nytimes.com/2016/07/26/health/skinny-fat.html?_r=0 Page 1 of 7 Skinny and 119 Pounds, but With the Health Hallmarks of Obesity - The New York Times 7/22/16, 2:42 PM in America, or at least five million people, have a grave accumulation of fat in their livers caused by obesity that can lead to liver failure. -
Sources and Bibliography
Sources and Bibliography AMERICAN EDEN David Hosack, Botany, and Medicine in the Garden of the Early Republic Victoria Johnson Liveright | W. W. Norton & Co., 2018 Note: The titles and dates of the historical newspapers and periodicals I have consulted regarding particular events and people appear in the endnotes to AMERICAN EDEN. Manuscript Collections Consulted American Philosophical Society Barton-Delafield Papers Caspar Wistar Papers Catharine Wistar Bache Papers Bache Family Papers David Hosack Correspondence David Hosack Letters and Papers Peale Family Papers Archives nationales de France (Pierrefitte-sur-Seine) Muséum d’histoire naturelle, Série AJ/15 Bristol (England) Archives Sharples Family Papers Columbia University, A.C. Long Health Sciences Center, Archives and Special Collections Trustees’ Minutes, College of Physicians and Surgeons Student Notes on Hosack Lectures, 1815-1828 Columbia University, Rare Book and Manuscript Library Papers of Aaron Burr (27 microfilm reels) Columbia College Records (1750-1861) Buildings and Grounds Collection DeWitt Clinton Papers John Church Hamilton Papers Historical Photograph Collections, Series VII: Buildings and Grounds Trustees’ Minutes, Columbia College 1 Duke University, David M. Rubenstein Rare Book & Manuscript Library David Hosack Papers Harvard University, Botany Libraries Jane Loring Gray Autograph Collection Historical Society of Pennsylvania Rush Family Papers, Series I: Benjamin Rush Papers Gratz Collection Library of Congress, Washington, DC Thomas Law Papers James Thacher -
Wendy Chung: Genetic Sleuth Is Advocate for Families
Spectrum | Autism Research News https://www.spectrumnews.org PROFILES Wendy Chung: Genetic sleuth is advocate for families BY DEBORAH RUDACILLE 21 JULY 2011 Triple threat: Colleagues say that Wendy Chung combines strengths in teaching, research and patient care with a finely tuned ethical sensibility. A few months ago, a young woman walked into Wendy Chung's office with a notebook and a flash drive. She said, "Here's my medical history, here's my genome, now you figure out what caused all this." This is exactly the kind of challenge that Chung relishes. A skilled genetic detective, she is adept at tracing an individual's symptoms to a particular genetic anomaly, teasing out its molecular ramifications and identifying the associated syndrome. According to those who know her well, that analytical bent is accompanied by a rare sensitivity. "I've known a lot of brilliant doctors and though she's at the top of the brilliance list, she also has a humanistic philosophy that animates everything she does," says Hamilton Cain, the father of one of Chung's patients. "She's not only thinking on all cylinders, but also feeling on all cylinders. She really connects with patients and their stories and their lives." Chung, who began her research career studying diabetes and obesity, is director of the clinical 1 / 4 Spectrum | Autism Research News https://www.spectrumnews.org genetics program at Columbia University Medical Center in New York as well as the university's fellowship program in clinical and molecular genetics. Two years ago, she moved into the autism field, accepting an invitation to serve as the principal investigator of the Simons Variation in Individuals Project (VIP), launched by the Simons Foundation, SFARI.org's parent organization. -
Storm Over Gender Gap Moves Into a Gray Area
وزارة اﻟﺗرﺑﯾﺔ واﻟﺗﻌﻠﯾم اﻟﻌﺎﻟﻲ اﻣﺗﺣﺎﻧﺎت ﺷﮭﺎدة اﻟﺛﺎﻧوﯾﺔ اﻟﻌﺎﻣﺔ دورة ﺳﻨﺔ ۲۰۰٥ اﻟﻌﺎدﯾﺔ اﻟﻣدﯾرﯾﺔ اﻟﻌﺎﻣﺔ ﻟﻠﺗرﺑﯾﺔ ﻓﺮﻋﺎ اﻟﻌﻠﻮم اﻟﻌﺎﻣﺔ وﻋﻠﻮم اﻟﺤﯿﺎة داﺋرة اﻻﻣﺗﺣﺎﻧﺎت ﻣﺳﺎﺑﻘﺔ ﻓﻲ: اﻟﻠﻐﺔ اﻻﻧﻛﻠﯾزﯾﺔ اﻻﺳم: اﻟﻣدة: ﺳﺎﻋﺗﺎن وﻧﺻف اﻟرﻗم: Part One: Reading (Score: 11/20) The writer in this article highlights the essential role of the hormone leptin in controlling obesity. Read it carefully, then answer the questions that follow. Obesity Control 1 New studies on mice suggest that the hormone leptin can fundamentally change the brain’s circuitry in areas that control appetite. Leptin acts during a critical period early in life, possibly influencing how much animals eat as adults. And later in life, responding to how much fat is on an animal’s body, it can again alter brain circuitry that controls how much is eaten. Researchers say the findings are a surprise and help explain why weight control is so hard for some people. 2 Scientists knew that leptin is released by fat cells and that it tells the brain how much fat is on the body. They knew that animals lacking leptin become incredibly obese and that a few humans who, because of genetic mutations do not make the hormone, are also immensely fat. 3 Leptin injections immediately made animals and the handful of patients with leptin deficiencies lose their appetites. Their weight returned to normal. 4 But it was thought that leptin acted like most other hormones by attaching itself to brain cells and directly altering their activities. 5 Some investigators did not expect that leptin could actually change connections in the brain, strengthening circuits that inhibit eating and weakening those that spur appetite. -
ITS IMPORTANCE in NEW YORK MED ICINE* PAUL CUSHMAN, JR. T HE Kissams Were a Large and Prominent Family In
689 THE KISSAM FAMILY: ITS IMPORTANCE IN NEW YORK MED ICINE* PAUL CUSHMAN, JR. Department of Internal Medicine St. Luke's Hospital Center New York, N. Y. T HE Kissams were a large and prominent family in New York City during most of the I8th and I9th centuries. Although especially eminent in commerce and in law, they also played a number of interest- ing roles in the history of American medicine.' This communication will present some of the most noteworthy contributions which the early members of the family made either to the development of medical practice or to the evolution of medical institutions. The family has been traced to John Ockasson who arrived in Cow Neck, Long Island (Now Manhasset-Great Neck), in the late I7th century. Since he spelled his surname in a variety of ways-about I8 different versions are recognized in real estate documents2-it is im- probable that his origins will ever be established. His son, Daniel, succeeded to the family farm and established the "Kissam" spelling of the surname. In eight generations that followed (see accompanying figure) 27 descendants of Daniel either practiced medicine or set out to do so by entering school. Of these, all but three bore the surname Kissam. Twenty-two members of the family actually practiced medicine. The accumulation of such a large number of physicians in one family is unique in American medicine to my knowledge. Further, the tendency of the medical Kissams to concentrate in the New York City area is remarkable. Seventeen Kissams were actively engaged in the practice of medicine at one time or another in the New York City area. -
Perella Weinberg Partners LP
Perella Weinberg Partners LP Peter Weinberg—Founding Partner Partner Peter Weinberg co-founded Perella Weinberg Partners, a private financial services firm, in June 2006 to provide M&A advisory and alternative asset management services. The firm has offices in New York and London and serves companies, families and institutions around the world. Mr. Weinberg has been in the investment banking industry for over 25 years. Prior to co-founding Perella Weinberg Partners, he served as chief executive officer of Goldman Sachs International, based in London. He was elected partner of the firm in 1992, co-headed the global investment banking division, and served on the management committee for six years. He also co-headed the partnership committee. Mr. Weinberg is on the board of BAE Systems PLC and GLG Partners, both are based in London. He has been committed to many educational institutions and currently serves on the boards of Deerfield Academy, Brunswick School, The Kravis Leadership Institute and the Kings Academy in Jordan. Mr. Weinberg graduated from Claremont McKenna College in 1979 and Harvard Business School in 1983. He currently lives outside of New York with his wife, Debby, and three children: Sidney, Charles and Henry. Q&A with Peter Weinberg What are some steps that you took to get to the position that you are in now? I spent almost 20 years at Goldman Sachs, which formed the bulk of my career. I left after having served as chief executive of Goldman Sachs International for seven years and came back to the United States. I lived in London while I served in that capacity and returned to the United States in 2005, when I decided that I wanted to start a new company. -
Common Cooking Spice Shows Promise in Combating Diabetes and Obesity 21 June 2008
Common cooking spice shows promise in combating diabetes and obesity 21 June 2008 Shown to reverse inflammation associated with The inflammation associated with obesity was obesity and improves blood sugar control shown several years ago by researchers in the Turmeric, an Asian spice found in many curries, Naomi Berrie Diabetes Center to be due in part to has a long history of use in reducing inflammation, the presence of immune cells called macrophages healing wounds and relieving pain, but can it in fat tissues throughout the body. These cells prevent diabetes? Since inflammation plays a big produce "cytokine" molecules that can cause role in many diseases and is believed to be inflammation in organs such as the heart, and islets involved in onset of both obesity and Type 2 of the pancreas, while also increasing insulin diabetes, Drew Tortoriello, M.D., an resistance in muscle and liver. Researchers endocrinologist and research scientist at the Naomi hypothesized that by suppressing the number and Berrie Diabetes Center at Columbia University activity of these cells, with turmeric or a drug with Medical Center, and his colleagues were curious similar actions, it may be possible to reduce some what effect the herb might have on diabetic mice. of the adverse consequences of obesity. Dr. Tortoriello, working with pediatric resident Curcumin administration was also associated with a Stuart Weisberg, M.D., Ph.D., and Rudolph Leibel, small but significant decline in body weight and fat M.D., fellow endocrinologist and the co-director of content, despite level or higher calorie the Naomi Berrie Diabetes Center, discovered that consumption, suggesting that curcumin beneficially turmeric-treated mice were less susceptible to influences body composition. -
Transactions of Society of Actuaries 1984 Vol, 36
TRANSACTIONS OF SOCIETY OF ACTUARIES 1984 VOL, 36 SKETCHES OF EARLY NORTH AMERICAN ACTUARIES E. J. MOORHEAD ABSTRACT This paper undertakes to give dossiers of essentially all the actuaries who entered our profession in Canada or the United States up to about 1872. It includes those who died or left our profession before the Actuarial Society of America was formed in April 1889, and those who, in due course, became Fellows of that Society when or after it came into being. The paper also mentions some of the conditions under which the Actuarial Society was organized, and suggests that a yet fuller story of how our prede- cessors coped with circumstances and events of more than a century ago would be a desirable record to document. Felix qui potuit return cognoscere causas.---Virgil (Happy is he who has been able to search out the causes of things.) INTRODUCTION Those who consider it important that a profession understand its own beginnings will agree that this paper should have been written at least sixty years ago -- early enough so that the facts would have been readily obtain- able, yet late enough so that actions taken, or not taken, might be viewed dispassionately. Those who regard the lessons of the past to be worth study- ing will wish, as this chronicler does, to see more done than has here been undertaken by way of placing on record the major events and the turning points of the stormy period in which our pioneers lived. It may yet be possible -- perhaps as preparation for our centenary -- to set forth appraisals of how our professional ancestors tackled such thorny problems as gross versus net premium valuations, tontine dividend systems, and sharing dis- coveries and ideas in an era of widespread mistrust. -
The Professor, the Bishop, and the Country Squire
THE PROFESSOR. THE BISHOP, AND THE COUNTRY SQUIRE CHAPTER IT Second, one of his most passionate interests was the increase in the num The Professor, the Bishop, ber of Episcopal ministers. He was committed to one way above all others to further this objective, namely to find sincere young men of good character and the Country Squire (and usually modest finances) and to help them obtain first a college and then a seminary education. Third, John McVickar was the most influential member, a charter trustee, and for a long time the Superintendent of the Society for Promoting Religion In 1935 in preparation for the 75th anniversary of the founding of the Col and Learning. This was an off-shoot of the great landed endowments of Trini lege, George H. Genzmer, librarian and lecturer in English at Bard, com ty Church, New York City, established in 1839 as a separate corporation for piled a chronology (which he entitled "Annals of the College") running the purpose of supporting the college and seminary training of aspirants for from the College's earliest beginnings up as far as 1918. This chronology is the ministry. Its assets consisted of lands in downtown New York, and in the more precise in its dating and covers a wider area of the College's life than 1850's were yielding $10,000 to $20,000 per year. (A century later the any other historical treatment of Bard. assets had increased to over a million dollars and the annual income to nearly Mr. Genzmer starts his list of the dates of the events which led up to the $100,000.)' The Society's steady, firm support proved to be the determina founding of the College, with the year 1787, the birth of John McVickar. -
NIDDK September 2020 Meeting Minutes
National Diabetes and Digestive and Kidney Diseases Advisory Council National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Department of Health and Human Services I. CALL TO ORDER Dr. Rodgers Dr. Griffin Rodgers, Director, NIDDK, called to order the 214th meeting of the National Diabetes and Digestive and Kidney Diseases Advisory Council at 10:30 a.m. on September 9, 2020, via Zoom videoconference. This meeting was conducted using a two-tiered webinar format. The panelist tier consisted of NIDDK's Advisory Council members and NIDDK staff members who presented during the meeting. The audience tier was available to members of the public and allowed them to view and listen to the meeting. A. ATTENDANCE – COUNCIL MEMBERS PRESENT Dr. David D’Alessio* Dr. Iain Drummond Dr. Richard Peek Dr. Penny Gordon-Larsen Dr. David Penson Dr. Lisa Guay-Woodford Dr. Jeffrey Pessin Dr. Barbara Kahn Ms. Ceciel Rooker Mr. Richard Knight Dr. Kathleen Sakamoto Dr. Rudolph Leibel + Dr. Ronald Sokol Mr. Thomas Nealon Dr. Gary Wu Dr. Mark Nelson Also Present: Dr. Griffin Rodgers, Director, NIDDK and Chair of the NIDDK Advisory Council Dr. Karl F. Malik, Executive Secretary, NIDDK Advisory Council Dr. Matthew Portnoy, Deputy Director, Division of Extramural Activities Dr. Gregory G. Germino, Deputy Director, NIDDK Dr. Stephen P. James, Director, Division of Digestive Diseases and Nutrition, NIDDK Dr. Robert A. Star, Director, Division of Kidney, Urologic, and Hematologic Diseases, NIDDK Dr. William Cefalu, Director, Division of Diabetes, Endocrinology and Metabolic Diseases, NIDDK * Ex officio member + Ad hoc member B. NIDDK PANELISTS/SPEAKERS Dr. -
Annual Report 2017
Central Park Conservancy ANNUAL REPORT 2017 Table of Contents 2 Partnership 4 Letter from the Conservancy President 5 Letter from the Chairman of the Board of Trustees 6 Letter from the Mayor and the Parks Commissioner 7 Serving New York City’s Parks 8 Forever Green 12 Honoring Douglas Blonsky 16 Craftsmanship 18 Native Meadow Opens in the Dene Landscape 20 Electric Carts Provide Cleaner, Quieter Transportation 21 Modernizing the Toll Family Playground 22 Restoring the Ramble’s Watercourse 24 Enhancing and Diversifying the Ravine 26 Conservation of the Seventh Regiment Memorial 27 Updating the Southwest Corner 28 Stewardship 30 Operations by the Numbers 32 Central Park Conservancy Institute for Urban Parks 36 Community Programs 38 Volunteer Department 40 Friendship 46 Women’s Committee 48 The Greensward Circle 50 Financials 74 Supporters 114 Staff & Volunteers 124 Central Park Conservancy Mission, Guiding Principle, Core Values, and Credits Cover: Hallett Nature Sanctuary, Left: Angel Corbett 3 CENTRAL PARK CONSERVANCY Table of Contents 1 Partnership Central Park Conservancy From The Conservancy Chairman After 32 years of working in Central Park, Earlier this year Doug Blonsky announced that after 32 years, he would be stepping down as the it hasn’t been an easy decision to step Conservancy’s President and CEO. While his accomplishments in that time have been too numerous to count, down as President and CEO. But this it’s important to acknowledge the most significant of many highlights. important space has never been more First, under Doug’s leadership, Central Park is enjoying the single longest period of sustained health in its beautiful, better managed, or financially 160-year history. -
M&A Spikes in Record Third Quarter As Boards Go on Pandemic Deal Spree | Reuters
M&A spikes in record third quarter as boards go on pandemic deal spree ... https://www.reuters.com/article/us-global-m-a-q3/ma-spikes-in-record-th... M&A spikes in record third quarter as boards go on pandemic deal spree Pamela Barbaglia, Joshua Franklin LONDON/NEW YORK (Reuters) - Mergers and acquisitions came back with a bang in the third quarter as executives rushed to revisit deals left on hold at the height of the coronavirus pandemic and boardrooms regained confidence after a roller-coaster year. FILE PHOTO: The Wall Street sign is pictured at the New York Stock exchange (NYSE) in the Manhattan borough of New York City, New York, U.S., March 9, 2020. REUTERS/Carlo Allegri/File Photo A deal frenzy in September led to a record third quarter with more than $1 trillion worth of transactions around the world, mostly focused on coronavirus-resilient sectors such as technology and healthcare, according to Refinitiv data. The third-quarter spike, however, failed to take up all the slack after a lacklustre start to the year. M&A deals overall were down 21% at $2.2 trillion in the first nine months of 2020, with U.S. transactions coming in at $800 billion, a 43% slump from the same period last year. "The way out of this crisis is through M&A and we have started to have really engaging conversations with CEOs and boards around strategic positioning post-COVID," said Alison Harding-Jones, Citigroup's C.N head of M&A for Europe, the Middle East and Africa (EMEA) and vice chairman of EMEA banking, capital markets and advisory.