P&Sannual Report 2007
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COLUMBIA UNIVERSITY COLLEGE OF PHYSICIANS AND SURGEONS ANNUAL REPORT 2007 Columbia University MedicalP Center &S TABLE OF CONTENTS Dean’s Message 2 Initiative and Investment 4 Treatments on the Cutting Edge: Patient Care 12 Dramatic Discoveries: Research 24 shaping Medicine’s Future: Education 34 In Our Community 44 Faculty Honors 52 Development 60 About P&S 69 Trustees Committee on the Health Sciences 69 CUMC Board of Visitors 69 Health Sciences Advisory Council 69 CUMC Administration 69 College of Physicians & Surgeons Administration 70 Executive Committee of the Faculty Council 70 Department Chairs 70 University Centers and Institutes and Directors 71 P&S Centers and Directors 71 affliated Hospitals 73 College of Physicians & Surgeons 2007 74 2 P&S 2007 ANNUAL REPORT FROM THE DEAN Last year I wrote as the new • The Lieber Clinic, a first-of-its-kind comprehen- dean, sharing with you my sive clinic for schizophrenia care located within goals for the future of an columbia’s Lieber Center for Schizophrenia institution I had only just Research. begun to lead. I described an objective that was both lofty • A new Division of Geriatric Medicine, an urgent and achievable: building on need in an aging society that at the same time an outstanding foundation is seeing a dearth of trained geriatricians — to ensure that Columbia Uni- and fewer medical students choosing to pursue versity College of Physicians training opportunities in the feld. & Surgeons would proudly occupy its rightful place as • A $51 million grant as part of the National one of the top fve medical Institutes of Health’s inaugural Clinical and schools in the world, if not Translational Science Awards. As one of the arguably No. 1. frst schools to have ctsa centers, columbia will be part of a national initiative to transform Since then, we have under- clinical and translational research. taken a number of efforts aimed at reaching that goal, and it is no exaggeration to say that the • Discovery of a new gene, SORL1, that contrib- clinical care, educational programs, and research utes to alzheimer’s disease through a previ- initiatives found at P&S are getting better with ously unknown cellular pathway. every passing day. This is no small feat. It may not be so diffcult to bring about noticeable • Renovation of the Augustus C. Long Health change and improvement in a routine environ- Sciences Library, creating 30,000 square feet of ment, but to take a world-class institution like classroom space, study spaces, and digital stor- P&S to even greater heights requires truly great age as part of a new education center. people combined with their extraordinary dedica- tion and effort. • Development of a new electronic health record for columbia’s 1,200-member ColumbiaDoc- As you read this year’s annual report, I hope you tors, the P&S faculty practice organization. The will be impressed and gratifed by the array of EHR will be used by physicians treating out- major new initiatives that cut across all felds and patients and will interface with the hospital’s disciplines. Some highlights are worth singling inpatient EHR. out for your attention: P&S 2007 ANNUAL REPORT 3 These are only a few highlights from a year flled In medicine, we understand that we dedicate our work with such achievements, a year in which we are moving toward a new pinnacle of excellence for to a future we ourselves may not live to see: the future Columbia. It also has been a year in which we generations we educate, the painstaking research ad- have made great progress toward one of my top priorities for this institution: attracting the best vances we glean in the laboratory, the changes in clini- possible minds to our programs, including lead- cal care that will transform not just one person’s life but ing clinicians and researchers, as well as medical students and residents who represent the bright- countless lives. est possibilities the future of health care has to offer. transform not just one person’s life but countless In less than two years, we have recruited such lives. some of these achievements may beneft top talents as neurogeneticist Maria Karay- us now, but many will reach fruition only later, iorgou, M.D., Ph.D., whose research in founder when we as individuals are no longer around to populations is helping to pave the way toward take credit. It is a truly great institution that takes a better understanding of schizophrenia; Linda on the work needed every day, while all the time Fried, M.D., M.P.H., a renowned geriatrics keeping an eye on that distant future, never specialist who has joined us as dean of the Mail- seeing the latest achievement as a fnish line, but man School of Public Health and whose joint rather just the next starting point. appointment in P&S will strengthen partnerships between the two schools; and leading infectious I would like to thank everyone who helped to diseases authority Lawrence R. Stanberry, M.D., make this year one of those next starting points Ph.D., who now chairs our Department of Pe- for great years and decades to come. diatrics and was a lead member of the research team that produced the frst scientifc evidence that a vaccine could protect humans against genital herpes. Lee Goldman, M.D. In medicine, we understand that we dedicate our work to a future we ourselves may not live to see: the future generations we educate, the painstaking research advances we glean in the laboratory, the changes in clinical care that will 4 P&S 2007 ANNUAL REPORT Initiative and Investment Great discoveries and advances that reshape the feld of medicine rarely emerge in isolation. Science and health care are at their best when brilliant minds from many disciplines work closely together and are given the resources and the freedom to pursue new challenges. This year at Columbia, important new grants and centers offered some of our most talented faculty the opportunity to follow important pursuits. P&S 2007 ANNUAL REPORT 5 6 P&S 2007 ANNUAL REPORT NEW HORIZONS FOR CLINICAL AND TRANSLATIONAL RESEARCH In October 2006, Columbia became one of the It will allow Columbia to expand its clinical and frst 12 academic health centers across the nation translational research space signifcantly, including to receive a National Institutes of Health inaugural a new center for community-based clinical and Clinical and Translational Science Award — an translational research, as well as an educational initiative aimed at transforming how clinical center where master’s and Ph.D. students can and translational research is conducted in the better interact and collaborate on research. United States. CTSA centers will form a national consortium focused on innovation, streamlining, The TRANSFORM programs (TRaining And and expediting clinical research and the delivery Nurturing Scientists FOr Research that is Multi- of new treatments to patients. NIH director Elias disciplinary) will provide training, support, and Zerhouni, M.D., called the initiative “the frst nurturing in a team-oriented environment to systematic change in our approach to clinical the next generation of clinical and translational research in 50 years.” researchers. Senior faculty will provide leadership and serve as mentors. The training and career Columbia will receive $51 million from the initia- development that comprise TRANSFORM will tive over fve years. the funding has transformed produce clinical and translational researchers well the Irving Center for Clinical Research into the prepared to direct multi- and interdisciplinary Irving Institute for Clinical and Translational research. Research with an ambitious aim: to re-engineer columbia’s research enterprise into a multidisci- the ctsa will, for the frst time, be able to plinary team model, using collaborative efforts to provide support for clinical research ongoing in move basic science discoveries from the lab into several of the intensive care units and emergency groundbreaking treatments in the hospital room, departments. The CTSA also will support the clinic, or doctor’s offce. development of Irving Fellowship positions for junior faculty and a new Ph.D. program in clinical “We expect this investment to allow exponen- research. The Ph.D. program will be one of just a tial growth in clinical research here at Columbia few programs in the country focused on clinical University Medical Center,” says Henry Ginsberg, research. M.D., principal investigator on the CTSA grant. P&S 2007 ANNUAL REPORT 7 “We expect this investment to allow exponential growth in clinical research here at Columbia University Medical Center.” — Henry Ginsberg, M.D. HeNRY GINSBeRG is the Irving Professor of Medicine and director of the Irving Institute for Clinical and Translational Research Melissa Begg, Sc.D., and Henry Ginsberg, M.D., co-directors of the Irving Institute for Clinical and Translational Research COMe TOGeTHeR: PILOT ReSeARCH PROjeCTS the four health sciences schools at columbia — The winner: a four-school team that will study medical, nursing, dental, and public health — to- why Hispanics with peripheral vascular disease gether are home to a unique breadth and depth fare worse than whites. Led by K. Craig Kent, of expertise in health care. A new four-school M.D., professor of surgery and chief of the pilot project encourages investigators at each of division of vascular surgery, who initially discov- these schools to collaborate across their respec- ered the disparity, the team will receive up to tive felds and disciplines, working together to $300,000 over two years thanks to the David answer broad questions that cannot be addressed A. Gardner New Initiatives Fund, created by by one feld alone. the interest in joining forces CUMC Board of Visitors member Lynn Shostack was so strong that 13 collaborations applied for in memory of her husband.